As physical education advances, college physical education classrooms are becoming increasingly diverse, but this development also brings security concerns. Intelligent sportswear, serving as a real-time monitoring device for human data, can enhance safety for both teachers and students. This study focuses on developing a conductive filler for flexible piezoresistive sensors using modified multi-walled carbon nanotubes (MWCNTs). Firstly, the tunneling theory and permeability effects are employed to establish a sensing mechanism model and analyze the conductivity and piezoresistive effects. Subsequently, silane coupling agents (KH550) and sodium dodecyl benzene sulfonate (SDBS) are chosen to enhance the conductive filler’s performance. Finally, smart gloves, smart insoles, and smart vests are designed for the detection of hand pressure, foot pressure, and respiratory rate. This aims to enhance safety measures in physical education classrooms. Furthermore, their performance is validated through simulation experiments. Results indicate that MWCNTs were modified with KH550 and SDBS, showing improved conductivity with higher filler concentration. KH550-SDBS-MWNT/PU material demonstrates 108.3% increased elongation at break, 9% reduction in nonlinear error, enhanced linearity, and 2.972 sensitivity increase. Displacement deviation analysis reveals load change trends based on filler concentration. Empirical analysis of smart clothing, like smart insoles, aligns sensor data with theoretical principles, highlighting the potential for flexible sensor performance enhancement. In conclusion, the modified MWCNs have demonstrated potential for enhancing the performance of flexible sensors.
{"title":"Application of smart sportswear based on multi-walled carbon nanotubes for safety in college physical education classes","authors":"Nan Hu, Baixu Wang","doi":"10.1166/mex.2023.2585","DOIUrl":"https://doi.org/10.1166/mex.2023.2585","url":null,"abstract":"As physical education advances, college physical education classrooms are becoming increasingly diverse, but this development also brings security concerns. Intelligent sportswear, serving as a real-time monitoring device for human data, can enhance safety for both teachers and students.\u0000 This study focuses on developing a conductive filler for flexible piezoresistive sensors using modified multi-walled carbon nanotubes (MWCNTs). Firstly, the tunneling theory and permeability effects are employed to establish a sensing mechanism model and analyze the conductivity and piezoresistive\u0000 effects. Subsequently, silane coupling agents (KH550) and sodium dodecyl benzene sulfonate (SDBS) are chosen to enhance the conductive filler’s performance. Finally, smart gloves, smart insoles, and smart vests are designed for the detection of hand pressure, foot pressure, and respiratory\u0000 rate. This aims to enhance safety measures in physical education classrooms. Furthermore, their performance is validated through simulation experiments. Results indicate that MWCNTs were modified with KH550 and SDBS, showing improved conductivity with higher filler concentration. KH550-SDBS-MWNT/PU\u0000 material demonstrates 108.3% increased elongation at break, 9% reduction in nonlinear error, enhanced linearity, and 2.972 sensitivity increase. Displacement deviation analysis reveals load change trends based on filler concentration. Empirical analysis of smart clothing, like smart insoles,\u0000 aligns sensor data with theoretical principles, highlighting the potential for flexible sensor performance enhancement. In conclusion, the modified MWCNs have demonstrated potential for enhancing the performance of flexible sensors.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"10 32","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. R. Sanjay Krishna, K. Sai Sarath, B. Nageswara Rao, V. Atgur, N. Banapurmath, Chandramouli Vadlamudi, Sanjay Krishnappa, M. A. Umarfarooq, A. M. Sajjan
Arc fusion processes, such as high-efficiency gas metal arc welding (GMAW), have become increasingly prevalent in various industries. To optimize the GMAW parameters and enhance the strength of MS 1018, Monika and Chauhan conducted experiments using the low carbon steel filler wire (ER 70 S6). They used a Taguchi L9 OA (orthogonal array) to generate test data focusing on 3 GMAW parameters such as gas flow rate, arc voltage, and welding current. The performance characteristics considered were tensile strength (TS), weld zone hardness (WZH), and heat-affected zone hardness (HAZH). The effect of GMAW parameters investigated using the S/N (signal-to-noise ratio) transformation of individual test data, which is valid to account for variations observed in repeated tests. By conducting a thorough analysis of variance (ANOVA) on this transformed data, they were able to identify the optimal GMAW parameters for achieving high TS, WZH, and HAZH. Given that HAZH exhibited higher values than WZH, it was evident that TS had the most significant impact on the GMAW process. Consequently, the researchers established empirical relationships for TS, WZH, and HAZH in terms of the GMAW parameters. Their test data aligned reasonably well with the expected range of performance indicators, supporting the validity of their findings. Overall, Monika and Chauhan’s modified Taguchi approach, based on the L9 OA, allowed them to efficiently conduct a limited number of tests while obtaining comprehensive information on the optimal GMAW parameters for enhancing the strength of MS 1018.
{"title":"Specification of the optimal gas metal arc welding (GMAW) parameters to enhance the mild steel strength (MS1018)","authors":"G. R. Sanjay Krishna, K. Sai Sarath, B. Nageswara Rao, V. Atgur, N. Banapurmath, Chandramouli Vadlamudi, Sanjay Krishnappa, M. A. Umarfarooq, A. M. Sajjan","doi":"10.1166/mex.2023.2562","DOIUrl":"https://doi.org/10.1166/mex.2023.2562","url":null,"abstract":"Arc fusion processes, such as high-efficiency gas metal arc welding (GMAW), have become increasingly prevalent in various industries. To optimize the GMAW parameters and enhance the strength of MS 1018, Monika and Chauhan conducted experiments using the low carbon steel filler wire\u0000 (ER 70 S6). They used a Taguchi L9 OA (orthogonal array) to generate test data focusing on 3 GMAW parameters such as gas flow rate, arc voltage, and welding current. The performance characteristics considered were tensile strength (TS), weld zone hardness (WZH), and heat-affected\u0000 zone hardness (HAZH). The effect of GMAW parameters investigated using the S/N (signal-to-noise ratio) transformation of individual test data, which is valid to account for variations observed in repeated tests. By conducting a thorough analysis of variance (ANOVA) on this transformed data,\u0000 they were able to identify the optimal GMAW parameters for achieving high TS, WZH, and HAZH. Given that HAZH exhibited higher values than WZH, it was evident that TS had the most significant impact on the GMAW process. Consequently, the researchers established empirical relationships for TS,\u0000 WZH, and HAZH in terms of the GMAW parameters. Their test data aligned reasonably well with the expected range of performance indicators, supporting the validity of their findings. Overall, Monika and Chauhan’s modified Taguchi approach, based on the L9 OA, allowed them to\u0000 efficiently conduct a limited number of tests while obtaining comprehensive information on the optimal GMAW parameters for enhancing the strength of MS 1018.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 39","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Based on occurrence, death and prevalence in 2019, GLOBOCAN reports 36 forms of cancer in 185 countries. At the moment, chemotherapy is the furthermost commonly utilized cancer management by resistant systems, gene and hormone therapeutics. Herein, we define a precise straightforward and cost-effective method that therapeutically incorporates drug reconstruction, macromolecular nano-assembled and specific tumor targeting to overcome the various experiments modelled via the distribution of the potential anticancer Iguratimod (IGU) drug. The IGU drugs were empowered to instinctually assembly into admirable, stable nanoparticles on the conjugations covalent interactions of hydrophobic linoleic acid bonded with an amide group of ∼100 nm. Various microscopic methods have proven synthesized IGU-NP morphology. Following effective fabrication, the IGU and IGU-NP anti-cancer properties of MCF-7 (breast carcinoma) and 4T1 (breast carcinoma) cell lines were assessed. Additional studies include AO-EB (acridine bromide orange ethidium), nuclear staining. In contrast with IGU, the IGU-NPs showed excellent cytocompatibility, this investigation explained that IGU-NPs are a healthy and encouraging solution in breast cancer chemotherapy and are worthy of further clinical assessment.
{"title":"Fabrication of self-assembly iguratimod prodrug into polymeric nanoparticles delivery for the care of breast cancer therapy","authors":"Xue Wang, Bing Wang","doi":"10.1166/mex.2023.2547","DOIUrl":"https://doi.org/10.1166/mex.2023.2547","url":null,"abstract":"Based on occurrence, death and prevalence in 2019, GLOBOCAN reports 36 forms of cancer in 185 countries. At the moment, chemotherapy is the furthermost commonly utilized cancer management by resistant systems, gene and hormone therapeutics. Herein, we define a precise straightforward\u0000 and cost-effective method that therapeutically incorporates drug reconstruction, macromolecular nano-assembled and specific tumor targeting to overcome the various experiments modelled via the distribution of the potential anticancer Iguratimod (IGU) drug. The IGU drugs were empowered to instinctually\u0000 assembly into admirable, stable nanoparticles on the conjugations covalent interactions of hydrophobic linoleic acid bonded with an amide group of ∼100 nm. Various microscopic methods have proven synthesized IGU-NP morphology. Following effective fabrication, the IGU and IGU-NP anti-cancer\u0000 properties of MCF-7 (breast carcinoma) and 4T1 (breast carcinoma) cell lines were assessed. Additional studies include AO-EB (acridine bromide orange ethidium), nuclear staining. In contrast with IGU, the IGU-NPs showed excellent cytocompatibility, this investigation explained that IGU-NPs\u0000 are a healthy and encouraging solution in breast cancer chemotherapy and are worthy of further clinical assessment.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 46","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fadi Baakdah, Abrar Ashi, Sarah Almaghrabi, K. A. Ismail, R. Sami, G. Alshehry, Huda Aljumayi, Eman Algarni, Jamal A Alorabi, Mohammad Y. Alshahrani, Naseh A Algehainy, Mohammad A Alanazi
Burn wounds need enhanced healing by using some workable agent for better treatments. The current work aimed to make a comparison between four types of honey and vaseline in ointment forms in-vivo using experimental rats. Several parameters have been evaluated such as wound epithelialization and vascular endothelial growth factor expression (VEGF) rates for skins. Some biochemical parameters such as nitrites (NO2) and fluorescence recovery after photobleaching (FRAP) were detected for serum. TNF-α immune response and hydroxyproline contents were also determined colorimetrically. Microbial infection of the burns was examined against Pseudomonas aeruginosa and Staphylococcus aureus strains. The wound epithelialization rate among animal groups after 15 days of treatment ranged from 52.13% to 89.58%. The highest VEGF expression rate was achieved by using the ointment formed by side honey (SIH) at 9.21% followed by pumpkin honey (PUH) at 8.54%, moringa honey (MOH) at 8.11%, and nigellasativa honey (NSH) as 7.02%, while vaseline group reported 5.22% VEGF expression. The ointment formed by the NSH rat group detected the highest NO2 at the end of the experimental work to reach (0.07 μmol/L) followed by SIH (0.06 μmol/L), while MOH and PUH groups reported equal values (0.05 μmol/L). The FRAP values varied in rat groups from 735.19 μmol TE/g (SIH) to 877.89 μmol TE/g (NSH). NSH reported the highest value for TNF-α immune response at 589.47 U/mL followed by SIH at 560.89 U/mL, while MOH reported the lowest value at 489.58 U/mL. For the microbial infections, the MOH group had the lowest zone of inhibition 5.18 mm, while the vaseline group reported the highest 19.88 mm against Pseudomonas aeruginosa. It was observed that the highest zone of inhibition (19.22 mm) against Staphylococcus aureus was for the vaseline group, while the lowest zone of inhibition (5.33 mm) against Staphylococcus aureus was for SIH. All honey varieties, especially MOH had better results for NO2, TNF-α immune response, and successfully inhibited microbial infections in-vivo.
{"title":"Healing processes of burn wounds with honey and vaseline as ointment forms: An in-vivo study in Wistar rats","authors":"Fadi Baakdah, Abrar Ashi, Sarah Almaghrabi, K. A. Ismail, R. Sami, G. Alshehry, Huda Aljumayi, Eman Algarni, Jamal A Alorabi, Mohammad Y. Alshahrani, Naseh A Algehainy, Mohammad A Alanazi","doi":"10.1166/mex.2023.2569","DOIUrl":"https://doi.org/10.1166/mex.2023.2569","url":null,"abstract":"Burn wounds need enhanced healing by using some workable agent for better treatments. The current work aimed to make a comparison between four types of honey and vaseline in ointment forms in-vivo using experimental rats. Several parameters have been evaluated such as wound epithelialization\u0000 and vascular endothelial growth factor expression (VEGF) rates for skins. Some biochemical parameters such as nitrites (NO2) and fluorescence recovery after photobleaching (FRAP) were detected for serum. TNF-α immune response and hydroxyproline contents were also determined\u0000 colorimetrically. Microbial infection of the burns was examined against Pseudomonas aeruginosa and Staphylococcus aureus strains. The wound epithelialization rate among animal groups after 15 days of treatment ranged from 52.13% to 89.58%. The highest VEGF expression rate was\u0000 achieved by using the ointment formed by side honey (SIH) at 9.21% followed by pumpkin honey (PUH) at 8.54%, moringa honey (MOH) at 8.11%, and nigellasativa honey (NSH) as 7.02%, while vaseline group reported 5.22% VEGF expression. The ointment formed by the NSH rat group detected the\u0000 highest NO2 at the end of the experimental work to reach (0.07 μmol/L) followed by SIH (0.06 μmol/L), while MOH and PUH groups reported equal values (0.05 μmol/L). The FRAP values varied in rat groups from 735.19 μmol TE/g (SIH) to 877.89\u0000 μmol TE/g (NSH). NSH reported the highest value for TNF-α immune response at 589.47 U/mL followed by SIH at 560.89 U/mL, while MOH reported the lowest value at 489.58 U/mL. For the microbial infections, the MOH group had the lowest zone of inhibition 5.18 mm, while the\u0000 vaseline group reported the highest 19.88 mm against Pseudomonas aeruginosa. It was observed that the highest zone of inhibition (19.22 mm) against Staphylococcus aureus was for the vaseline group, while the lowest zone of inhibition (5.33 mm) against Staphylococcus aureus\u0000 was for SIH. All honey varieties, especially MOH had better results for NO2, TNF-α immune response, and successfully inhibited microbial infections in-vivo.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiaoling Sun, Xiaozhao Zhao, Bei Jin, Baotong Shu, Yu Ma
We conducted cellular and animal experiments to investigate the correlation between miR-124/SBK1 and retinoblastoma (RB) progression, as well as to elucidate the anti-cancer efficacy of chaetocin in RB. Initially, miR-124 levels showed a significant decrease in RB tissues and cells, which further declined with increasing tumor diameter and clinical stage. In cellular experiments, inhibiting miR-124 expression significantly enhanced the viability and invasiveness of Y79 cells, while up-regulating miR-124 suppressed the malignant biology of Y79 cells by targeting SBK1 levels, thereby reducing their viability and invasiveness. Subsequent animal experiments provided further evidence that SBK1 was the functional target of miR-124, and its up-regulation significantly facilitated RB progression. Additionally, chaetocin demonstrated anti-tumor effects through the upregulation of miR-124 and downregulation of SBK1. Therefore, chaetocin can effectively inhibit RB progression by targeting the upregulation of miR-124 and downregulation of SBK1.
{"title":"Inhibition of chaetocin on retinoblastoma progression by modulating the miR-124/SBK1 axis","authors":"Qiaoling Sun, Xiaozhao Zhao, Bei Jin, Baotong Shu, Yu Ma","doi":"10.1166/mex.2023.2510","DOIUrl":"https://doi.org/10.1166/mex.2023.2510","url":null,"abstract":"We conducted cellular and animal experiments to investigate the correlation between miR-124/SBK1 and retinoblastoma (RB) progression, as well as to elucidate the anti-cancer efficacy of chaetocin in RB. Initially, miR-124 levels showed a significant decrease in RB tissues and cells,\u0000 which further declined with increasing tumor diameter and clinical stage. In cellular experiments, inhibiting miR-124 expression significantly enhanced the viability and invasiveness of Y79 cells, while up-regulating miR-124 suppressed the malignant biology of Y79 cells by targeting SBK1 levels,\u0000 thereby reducing their viability and invasiveness. Subsequent animal experiments provided further evidence that SBK1 was the functional target of miR-124, and its up-regulation significantly facilitated RB progression. Additionally, chaetocin demonstrated anti-tumor effects through the upregulation\u0000 of miR-124 and downregulation of SBK1. Therefore, chaetocin can effectively inhibit RB progression by targeting the upregulation of miR-124 and downregulation of SBK1.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 45","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigated the effectiveness of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask in radiotherapy for head and neck neoplasms. The images of 50 patients with head and neck neoplasms treated at our hospital from 2020 to 2022 were collected using CBCT. The patients were divided into two groups: 25 in the mask group and 25 in the combination group. The mask group utilized thermoplastic polyurethane (TPU) nanofiber membrane to stabilize the position of the patients’ head, shoulder, and neck. On the other hand, the combined group added a personalized bite block produced by 3D printing technology on the basis of the mask group. Cone beam CT (CBCT) was used to calibrate any errors, and the set-up errors and number of head rotations after image calibration were analyzed between the two groups. The conformation number (CN) and heterogeneity index (HI) in the target area of the intensity-modulated radiation therapy (IMRT) plan of the two groups were calculated, and the dose-volume parameters of the tongue and other organs at risk, including Dmax and Dmean, were compared using paired tests. Follow-up observations were performed to assess the occurrence of adverse reactions to radiation damage among the patients. The findings revealed a statistically significant difference in the Y -axis set-up error between the combination group and the mask group (P < 0.05). Additionally, the combination group exhibited a higher proportion of set-up errors < 2 mm in both the Y -axis and Z-axis directions compared to the mask group. Significantly fewer images showed head rotation in the combination group than in the mask group. In terms of the target area, there were no significant differences observed in the conformation number (CN) and heterogeneity index (HI) between the two groups. However, wearing the personalized bite block resulted in significantly lower Dmax and Dmean values for the tongue. In contrast, the mask group experienced a higher incidence of oral mucositis and taste disorders. By utilizing customizable 3D-printed bite blocks in conjunction with a nano-mask, accurate repositioning for chemotherapy was achieved, leading to a reduction in set-up error and a significant decrease in radiation dose to the tongue and its surface oral mucosa. Consequently, the occurrence of adverse reactions such as oral mucositis and taste disorders was also reduced. The production of personalized bite blocks is simple, with accurate radiotherapy, making it a technique that should be widely adopted.
{"title":"Application of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask to head and neck neoplasm radiotherapy","authors":"Chunyuan Zheng, Xueya Li, Luchao Zhu, Zhiqiang Zhang, Yuanzhang Wang, Yihang Lin, Qiong Wu, Meiling Zhang","doi":"10.1166/mex.2023.2578","DOIUrl":"https://doi.org/10.1166/mex.2023.2578","url":null,"abstract":"This study investigated the effectiveness of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask in radiotherapy for head and neck neoplasms. The images of 50 patients with head and neck neoplasms treated at our hospital from 2020 to 2022 were collected\u0000 using CBCT. The patients were divided into two groups: 25 in the mask group and 25 in the combination group. The mask group utilized thermoplastic polyurethane (TPU) nanofiber membrane to stabilize the position of the patients’ head, shoulder, and neck. On the other hand, the combined\u0000 group added a personalized bite block produced by 3D printing technology on the basis of the mask group. Cone beam CT (CBCT) was used to calibrate any errors, and the set-up errors and number of head rotations after image calibration were analyzed between the two groups. The conformation number\u0000 (CN) and heterogeneity index (HI) in the target area of the intensity-modulated radiation therapy (IMRT) plan of the two groups were calculated, and the dose-volume parameters of the tongue and other organs at risk, including Dmax and Dmean, were compared using paired tests. Follow-up observations\u0000 were performed to assess the occurrence of adverse reactions to radiation damage among the patients. The findings revealed a statistically significant difference in the Y -axis set-up error between the combination group and the mask group (P < 0.05). Additionally, the combination\u0000 group exhibited a higher proportion of set-up errors < 2 mm in both the Y -axis and Z-axis directions compared to the mask group. Significantly fewer images showed head rotation in the combination group than in the mask group. In terms of the target area, there were no significant\u0000 differences observed in the conformation number (CN) and heterogeneity index (HI) between the two groups. However, wearing the personalized bite block resulted in significantly lower Dmax and Dmean values for the tongue. In contrast, the mask group experienced a higher incidence of oral mucositis\u0000 and taste disorders. By utilizing customizable 3D-printed bite blocks in conjunction with a nano-mask, accurate repositioning for chemotherapy was achieved, leading to a reduction in set-up error and a significant decrease in radiation dose to the tongue and its surface oral mucosa. Consequently,\u0000 the occurrence of adverse reactions such as oral mucositis and taste disorders was also reduced. The production of personalized bite blocks is simple, with accurate radiotherapy, making it a technique that should be widely adopted.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 4","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The demand for high-grade roads is significantly higher in developing countries. However, slopes containing coal gangue weak interlayer pose significant safety risks to highways, railways, and other infrastructures. To address this issue, this study aims to find the best polymer cement ratio scheme of traditional pure acrylic emulsion polymer curing agents. Based on this scheme, a reinforcement method was designed, which combined modified polyvinyl acetate with the coal gangue soft interlayer. The slope test results using a rigid model box showed that the shear strength of the root–soil composite in the PVAC group was higher than that in the pure acrylic emulsion group under different vertical consolidation pressures. Over time, the cumulative soil loss rate of the pure acrylic emulsion group gradually increased, and the soil pH decreased. Conversely, the PVAC group showed minimal changes in these two indicators with time. Under the same conditions, the slope shear strength of the PVAC group remained stronger than that of the pure acrylic emulsion group. The standard deviations of multiple tests for the PVAC group and pure acrylic emulsion group, under a vertical consolidation pressure of 100 kPa, were 7.2 kPa and 9.2 kPa, respectively, indicating greater stability in the PVAC group. With a stability coefficient of 3.39, which surpasses that of the pure acrylic emulsion group, the PVAC group exhibited enhanced slope stability. These results indicate that this method can effectively enhance the stability of coal gangue soft interlayer slopes without causing environmental pollution.
{"title":"Soft intercalated slope stability optimization with a modified polymer curing agent","authors":"Yun He","doi":"10.1166/mex.2023.2559","DOIUrl":"https://doi.org/10.1166/mex.2023.2559","url":null,"abstract":"The demand for high-grade roads is significantly higher in developing countries. However, slopes containing coal gangue weak interlayer pose significant safety risks to highways, railways, and other infrastructures. To address this issue, this study aims to find the best polymer cement\u0000 ratio scheme of traditional pure acrylic emulsion polymer curing agents. Based on this scheme, a reinforcement method was designed, which combined modified polyvinyl acetate with the coal gangue soft interlayer. The slope test results using a rigid model box showed that the shear strength\u0000 of the root–soil composite in the PVAC group was higher than that in the pure acrylic emulsion group under different vertical consolidation pressures. Over time, the cumulative soil loss rate of the pure acrylic emulsion group gradually increased, and the soil pH decreased. Conversely,\u0000 the PVAC group showed minimal changes in these two indicators with time. Under the same conditions, the slope shear strength of the PVAC group remained stronger than that of the pure acrylic emulsion group. The standard deviations of multiple tests for the PVAC group and pure acrylic emulsion\u0000 group, under a vertical consolidation pressure of 100 kPa, were 7.2 kPa and 9.2 kPa, respectively, indicating greater stability in the PVAC group. With a stability coefficient of 3.39, which surpasses that of the pure acrylic emulsion group, the PVAC group exhibited enhanced slope stability.\u0000 These results indicate that this method can effectively enhance the stability of coal gangue soft interlayer slopes without causing environmental pollution.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 27","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138618581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Holmium (Ho) modified TiO 2 (Ho–TiO 2 ) nanocomposites have been prepared by a sol–gel process, and were used as an effective adsorbent and matrix for the enrichment and analysis of bisphenol S and Indigo by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The low detection limits of bisphenol S (BPS) and Indigo (ID) are 0.1 pg·mL −1 and 5 pg·mL −1 , respectively. Extremely BPS detection could be achieved in tea samples with good recovery (81.5–93.0%).
{"title":"Holmium modified TiO<sub>2</sub> nanocomposites as a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry matrix for the detection of bisphenol S and indigo","authors":"Jing Yang, Qiuhui Deng, Chunhua Luo, Aofeng Yang, Xiaohu Luo, Meng Guo, Lichun Fu, Deshuai Zhen, Huang Zhou","doi":"10.1166/mex.2023.2549","DOIUrl":"https://doi.org/10.1166/mex.2023.2549","url":null,"abstract":"Holmium (Ho) modified TiO 2 (Ho–TiO 2 ) nanocomposites have been prepared by a sol–gel process, and were used as an effective adsorbent and matrix for the enrichment and analysis of bisphenol S and Indigo by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The low detection limits of bisphenol S (BPS) and Indigo (ID) are 0.1 pg·mL −1 and 5 pg·mL −1 , respectively. Extremely BPS detection could be achieved in tea samples with good recovery (81.5–93.0%).","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"105 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Wang, Xiaojuan Wang, Shengli Wang, Xuehong Xian, Jiaxin Ye
To explore the postoperative rehabilitative effect of continuity of nursing care and nanomaterial oral nursing intervention in patients with spinal cord injuries (SCI). Eighty patients with SCIs from spinal fractures, who were treated in our hospital from January 2019 to August 2021, were randomly divided into control and nursing groups ( n = 40 each). The control group patients received conventional nursing care, while the nursing group received continuity of care (regular timely follow-ups, guided diet and medication plans, and countermeasures for complications) and oral care using nanoscale carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) composite particles. Perioperative indicators, complication rates, oral and dental scores, and satisfaction with nursing care were compared postoperatively between the two groups. Control group patients had significantly higher out of bed activity time, hospitalization time, hospitalization expenses, and incidence of complications than those in the nursing group. Additionally, they had higher serum levels of inflammatory markers (TGF- β 1, IL-6, and TNF- α ) than the nursing group ( P <0.05). On the other hand, the nursing group had higher oral scores and significantly lower buccal plaque index than the control group. Lastly, satisfaction rates were higher in the nursing group (97.5%) than in the control group. Continuity of care in SCI patients is an effective nursing approach to minimize the incidence of postoperative debilitating infections and related complications, and facilitate recovery. Additional oral care using nano-CMC/ACP composites can improve oral health in these patients.
{"title":"Effect of carboxymethyl chitosan/amorphous calcium phosphate complexes on postoperative infection in patients with spinal cord injury","authors":"Hao Wang, Xiaojuan Wang, Shengli Wang, Xuehong Xian, Jiaxin Ye","doi":"10.1166/mex.2023.2550","DOIUrl":"https://doi.org/10.1166/mex.2023.2550","url":null,"abstract":"To explore the postoperative rehabilitative effect of continuity of nursing care and nanomaterial oral nursing intervention in patients with spinal cord injuries (SCI). Eighty patients with SCIs from spinal fractures, who were treated in our hospital from January 2019 to August 2021, were randomly divided into control and nursing groups ( n = 40 each). The control group patients received conventional nursing care, while the nursing group received continuity of care (regular timely follow-ups, guided diet and medication plans, and countermeasures for complications) and oral care using nanoscale carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) composite particles. Perioperative indicators, complication rates, oral and dental scores, and satisfaction with nursing care were compared postoperatively between the two groups. Control group patients had significantly higher out of bed activity time, hospitalization time, hospitalization expenses, and incidence of complications than those in the nursing group. Additionally, they had higher serum levels of inflammatory markers (TGF- β 1, IL-6, and TNF- α ) than the nursing group ( P <0.05). On the other hand, the nursing group had higher oral scores and significantly lower buccal plaque index than the control group. Lastly, satisfaction rates were higher in the nursing group (97.5%) than in the control group. Continuity of care in SCI patients is an effective nursing approach to minimize the incidence of postoperative debilitating infections and related complications, and facilitate recovery. Additional oral care using nano-CMC/ACP composites can improve oral health in these patients.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"105 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Feng, Ping Fan, Minglin Zheng, Yi Guo, Lulu He, Min Long
Gastrointestinal tumors are highly malignant tumors and liquiritigenin can be used for prevention and development of chronic diseases related to inflammation. But its role in gastric cancer cells is elusive. Gastric cancer cells were treated with liquiritigenin for 48 hours. After treatment, assays were conducted to assess cell activity. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis determined the expression of miR-4534 and dual-luciferase reporter gene assay explored the downstream target genes of miR-4534. Transfection of anti-miR-4534 was carried out to investigate its role in gastric cancer cell growth and proliferation. Liquiritigenin treatment resulted in increased miR-4534 expression in gastric cancer when suppressing cell proliferation and inducing apoptosis. PTEN was a target of miR-4534. Interestingly, miR-4534 inhibitor abrogated the inhibitory effect of liquiritigenin on cancer cell growth, enhancing cell proliferation and facilitating cell cycle ( P < 0.05). In conclusion, liquiritigenin inhibit gastric cancer cell growth through upregulation of miR-4534 to regulate PTEN expression. Inhibiting the expression of miR-4534 can significantly promote gastric cancer progression, thereby reversing the anticancer effect of liquiritigenin.
{"title":"Liquiritigenin suppresses gastric cancer cells through regulating miR-4534 to target phosphatase and tensin homolog","authors":"Yang Feng, Ping Fan, Minglin Zheng, Yi Guo, Lulu He, Min Long","doi":"10.1166/mex.2023.2528","DOIUrl":"https://doi.org/10.1166/mex.2023.2528","url":null,"abstract":"Gastrointestinal tumors are highly malignant tumors and liquiritigenin can be used for prevention and development of chronic diseases related to inflammation. But its role in gastric cancer cells is elusive. Gastric cancer cells were treated with liquiritigenin for 48 hours. After treatment, assays were conducted to assess cell activity. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis determined the expression of miR-4534 and dual-luciferase reporter gene assay explored the downstream target genes of miR-4534. Transfection of anti-miR-4534 was carried out to investigate its role in gastric cancer cell growth and proliferation. Liquiritigenin treatment resulted in increased miR-4534 expression in gastric cancer when suppressing cell proliferation and inducing apoptosis. PTEN was a target of miR-4534. Interestingly, miR-4534 inhibitor abrogated the inhibitory effect of liquiritigenin on cancer cell growth, enhancing cell proliferation and facilitating cell cycle ( P < 0.05). In conclusion, liquiritigenin inhibit gastric cancer cell growth through upregulation of miR-4534 to regulate PTEN expression. Inhibiting the expression of miR-4534 can significantly promote gastric cancer progression, thereby reversing the anticancer effect of liquiritigenin.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"104 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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