The development of non-invasive sensor detection systems is crucial for the effective diagnosis of many types of cancer, including breast cancer. Currently, many diagnostic tools such as CT, mammography, MRI, and ultrasound are used, but more convenient and user-friendly sensors are under development. New sensors provide immediate and non-invasive ways to assess the impact of treatment on physiologic markers and overall disease progression. Innovative devices like iBreastExam, Skinsar™, and iTBra, include personalized sensors such as wearables and non-wearable sensors implanted inside the body. Early methods of detecting breast cancer can be accurate and cost-effective. Recurrence can be predicted and monitored through chemical sensors that detect tumor DNA or proteins circulating in the blood. In addition, monitoring patients with cancer using smart implants, thermal sensors, and image-based sensors provides capability at the level of tissue structure. This article provides an overview of the various sensors used in monitoring cancer patients.