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Extraction, Synthesis, Characterization, and Molecular Docking Evaluation of a Chitosan-Supported Schiff Base Derivative for Antifungal and Antimicrobial Applications 壳聚糖负载希夫碱衍生物的提取、合成、表征及分子对接评价
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-30 DOI: 10.1002/app.70168
Salim Madani, Kamel Mokhnache, Souhib Bennaadja, Lynda Aroui, Noureddine Charef, Lokmane Abdelouahed, Marta F. Garcia, Daniel L. Garcia, Mohammad Raish, Yacine Benguerba

Chitosan was extracted from local shrimp shells with a yield of 35.0% and converted into a novel Schiff-base derivative (Cht-SS-TIP) through condensation with 4-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]pentan-2-one. Structural confirmation via FTIR, elemental analysis, and SEM demonstrated successful functionalization, achieving a degree of deacetylation of 74.6% and a high substitution degree of 61.0%. Cht-SS-TIP exhibited a substantial improvement in biological performance relative to native chitosan. Antibacterial assays showed increased killing efficiencies ranging from 64% to 88%, with the strongest activity against Staphylococcus aureus and Bacillus subtilis. Antifungal evaluation revealed potent inhibition of 88% for Aspergillus fumigatus and 84% for A. niger, outperforming unmodified chitosan by more than 20%. Molecular docking against the Pseudomonas aeruginosa LasR quorum-sensing regulator further supported these findings, yielding a favorable binding score of −8.4 kcal/mol and demonstrating stable interactions through hydrogen bonding with LEU110, THR75, ASP65, and π–π stacking with TRP88. The low re-docking RMSD values (1.56 Å for the native ligand and 1.63 Å for Cht-SS-TIP) confirm protocol reliability. Overall, this study establishes Cht-SS-TIP as a high-performance chitosan derivative that synergistically enhances antimicrobial efficacy through structural modification and quorum-sensing inhibition, positioning it as a promising, sustainable candidate for disinfectant formulations and anti-virulence strategies targeting resistant pathogens.

以当地虾壳为原料,以35.0%的收率提取壳聚糖,并与4-[(5-磺胺基-1,3,4-噻二唑-2-基)亚氨基]戊烷-2- 1缩合,制得新型希夫碱衍生物(Cht-SS-TIP)。通过FTIR、元素分析和SEM的结构证实,功能化成功,实现了74.6%的脱乙酰度和61.0%的高取代度。与天然壳聚糖相比,Cht-SS-TIP的生物性能有了很大的提高。抑菌试验表明,其对金黄色葡萄球菌和枯草芽孢杆菌的杀伤效率在64% ~ 88%之间。抗真菌评价显示,壳聚糖对烟曲霉的抑制率为88%,对黑曲霉的抑制率为84%,比未修饰的壳聚糖高出20%以上。与铜绿假单胞菌激光r群体感应调节因子的分子对接进一步支持了这些发现,获得了−8.4 kcal/mol的良好结合评分,并通过与LEU110、THR75、ASP65的氢键和与TRP88的π -π堆叠表现出稳定的相互作用。低的再对接RMSD值(原生配体为1.56 Å, ht- ss - tip为1.63 Å)证实了协议的可靠性。总的来说,本研究确定了Cht-SS-TIP是一种高性能的壳聚糖衍生物,通过结构修饰和群体感应抑制协同增强抗菌功效,将其定位为一种有前途的、可持续的消毒剂配方和针对耐药病原体的抗毒策略候选物。
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引用次数: 0
Three-Dimensionally Printed HEMA–TRIS Hydrogel Contact Lenses With Optimized Optical, Mechanical, and Antibacterial Performance 三维打印HEMA-TRIS水凝胶隐形眼镜与优化的光学,机械和抗菌性能
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-30 DOI: 10.1002/app.70277
Halide Melik, Serife Yalcin, Bulent Aktas, Hatice Gumushan Aktas, Ebru Uyar, Zeynep Celik, Busra Ergin, Gokhan Demircan, Mehmet Vehbi Balak

This study integrates digital light processing (DLP)-based additive manufacturing with systematic modulation of trimethylsilyl silane (TRIS) content to elucidate the combined effects of formulation and processing on the performance of 2-hydroxyethyl methacrylate (HEMA)-based hydrogel contact lenses. HEMA hydrogels containing 0–20 wt% TRIS were fabricated via DLP 3D printing and evaluated in terms of physical, optical, thermal, mechanical, and biological properties. Equilibrium water content ranged from 22% to 36%, reaching full swelling within 24 h, while static water contact angles varied between 43° and 63°. All samples exhibited excellent optical transparency (95.8%–98.5%) in the visible range, with effective UV blocking below 240 nm. Differential scanning calorimetry showed that the glass transition temperature increased from 14°C (HT0) to 47°C at 10 wt% TRIS, followed by a slight decrease at higher TRIS contents. Dry-state tensile strength decreased with increasing TRIS, whereas hydrated samples exhibited reduced strength but enhanced elongation. Cytocompatibility tests using ARPE-19 cells confirmed high viability (≥ 96%) for all formulations. Protein adsorption remained low, and bacterial adhesion was significantly reduced, particularly against Escherichia coli and Staphylococcus aureus , with maximum reductions observed at 5–10 wt% TRIS. Overall, formulations containing 5–10 wt% TRIS provided an optimal balance of hydration, transparency, thermal stability, mechanical compliance, and antimicrobial performance, highlighting their potential for biocompatible contact lens applications.

本研究将基于数字光处理(DLP)的增材制造与三甲基硅基硅烷(TRIS)含量的系统调制相结合,以阐明配方和加工对甲基丙烯酸2-羟乙基(HEMA)基水凝胶隐形眼镜性能的综合影响。通过DLP 3D打印制备了含有0-20 wt% TRIS的HEMA水凝胶,并对其物理、光学、热、机械和生物性能进行了评估。平衡含水量在22% ~ 36%之间,24 h内达到完全溶胀,静水接触角在43°~ 63°之间。所有样品在可见光范围内具有良好的光学透明度(95.8%-98.5%),在240 nm以下具有有效的紫外线阻隔。差示扫描量热法表明,当TRIS含量为10 wt%时,玻璃化转变温度从14°C (HT0)上升到47°C,在TRIS含量较高时,玻璃化转变温度略有下降。干态拉伸强度随TRIS的增加而降低,而水合试样强度降低,伸长率提高。使用ARPE-19细胞进行细胞相容性试验,证实所有制剂具有高存活率(≥96%)。蛋白质吸附仍然很低,细菌粘附明显减少,特别是对大肠杆菌和金黄色葡萄球菌的粘附,在5-10 wt% TRIS时观察到最大的减少。总体而言,含有5-10 wt% TRIS的配方提供了水合作用、透明度、热稳定性、机械顺应性和抗菌性能的最佳平衡,突出了它们在生物相容性隐形眼镜应用中的潜力。
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引用次数: 0
Production of Elastomeric Composites With Different Methods of Incorporating of Graphene Nanoplatelets Into SBR Latex 石墨烯纳米片加入SBR胶乳的不同方法制备弹性复合材料
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-29 DOI: 10.1002/app.70270
Micaela D. Ferrari, Willian B. Ribeiro, Aline Zanchet, Diego Piazza, Rosmary N. Brandalise

This study investigates scalable methodologies for incorporating graphene nanoplatelets (GNPs) into styrene-butadiene rubber (SBR) latex, comparing powder form (GNP) and masterbatch (MB), with and without dodecyltrimethylammonium bromide (DTAB) surfactant. The formulations (0.5% w/w GNP or MB; DTAB in a 1:1 ratio) adhere to the standards outlined in ASTM D3185-09. The curing process involves mechanical agitation, coagulation, drying, milling, and vulcanization at 160°C. The incorporation of DTAB into MB results in a 78% reduction in the optimum vulcanization time (t 90) compared to the control (CSBR) and an approximate 78% increase in the maximum torque (M H). The hardness of CSBR/MB/DTAB increased by 5.5% compared to CSBR, and the permanent deformation decreased by 28%. The tensile strength of CSBR/MB increased by 74% in comparison with CSBR, while CSBR/GNP/DTAB demonstrated an increase of 50%. The thermal conductivity of CSBR/GNP exceeds that of CSBR by 15.2%. Subsequent to thermal aging, CSBR/GNP/DTAB demonstrates enhanced resistance: The data demonstrate a 54.5% increase at 7 days and a 45.4% increase at 14 days in comparison to CSBR. It can be concluded that the combination of masterbatch and DTAB surfactant optimizes GNP dispersion in SBR, making industrial processes without ultrasound viable.

本研究探讨了将石墨烯纳米片(GNPs)掺入丁苯橡胶(SBR)乳胶的可扩展方法,比较了粉末形式(GNP)和母粒形式(MB),分别使用和不使用十二烷基三甲基溴化铵(DTAB)表面活性剂。配方(0.5% w/w GNP或MB; DTAB按1:1的比例)符合ASTM D3185-09中概述的标准。固化过程包括机械搅拌、混凝、干燥、研磨和在160°C下的硫化。与对照组(CSBR)相比,将DTAB掺入MB可使最佳硫化时间(t 90)缩短78%,最大扭矩(M H)增加约78%。与CSBR相比,CSBR/MB/DTAB的硬度提高了5.5%,永久变形降低了28%。与CSBR相比,CSBR/MB的拉伸强度提高了74%,而CSBR/GNP/DTAB的拉伸强度提高了50%。CSBR的导热系数/GNP比CSBR高出15.2%。在热老化之后,CSBR/GNP/DTAB表现出增强的抗性:数据显示,与CSBR相比,在7天增加了54.5%,在14天增加了45.4%。由此可见,母粒和DTAB表面活性剂的组合优化了SBR中GNP的分散,使无超声的工业工艺可行。
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引用次数: 0
Energy Dissipation–Based Temperature Change Analysis of Loaded PMMA During Cyclic Loading 基于能量耗散的加载PMMA循环加载温度变化分析
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-29 DOI: 10.1002/app.70260
Wenfang Liu, Shanjun Liu, Xin Han, Lianhuan Wei, Ankui Zhu, Huashuo Cui

The thermal response of polymethyl methacrylate (PMMA) during deformation is highly relevant to its mechanical properties. In this study, temperature observation experiments were conducted on PMMA under uniaxial tiered cyclic loading. The temperature change characteristics and their mechanisms before yielding were investigated based on dissipated energy. The deformation of PMMA before yielding can be subdivided into four stages: linear elastic deformation, nonlinear deformation, pre–yielding, and yielding stage. Heat generation in loaded PMMA mainly includes the thermoelastic effect, viscous dissipation effect, and thermoplastic effect. Both viscous dissipation effect and thermoplastic effect cause the temperature and stress to deviate from linearity. The temperature decrease exhibits hysteresis relative to the stress under the unloading condition. The temperature hysteresis at low stress levels can be attributed to viscous deformation, while at high stress levels, it is primarily due to plastic deformation. Besides, some “irrecoverable temperature” cannot be recovered at the end of each cycle. The significant stage characteristics of the irrecoverable temperature are highly consistent with the deformation. This study suggests that temperature is an important parameter for reflecting the PMMA properties, and provides a new idea for monitoring and identifying the deformation regimes of the PMMA.

聚甲基丙烯酸甲酯(PMMA)在变形过程中的热响应与其力学性能密切相关。本研究对PMMA进行了单轴分层循环加载下的温度观测实验。基于耗散能,研究了屈服前的温度变化特征及其机理。PMMA屈服前的变形可分为线性弹性变形、非线性变形、预屈服和屈服四个阶段。加载PMMA的产热主要包括热弹性效应、粘滞耗散效应和热塑性效应。粘滞耗散效应和热塑性效应都会导致温度和应力偏离线性。在卸载条件下,相对于应力,温度下降表现出滞后性。在低应力水平下,温度滞后可归因于粘性变形,而在高应力水平下,温度滞后主要是由于塑性变形。此外,在每个循环结束时,有些“不可恢复的温度”无法恢复。不可恢复温度的显著阶段特征与变形高度一致。研究表明,温度是反映PMMA性能的重要参数,为监测和识别PMMA的变形机制提供了新的思路。
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引用次数: 0
Dual-Functional PANI/CeO Nanocomposites for Enhanced ROS-Mediated Apoptosis in HCT-116 Human Colon Cancer Cells and Antibacterial Applications 双功能聚苯胺/CeO纳米复合材料增强ros介导的HCT-116人结肠癌细胞凋亡及其抗菌应用
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-29 DOI: 10.1002/app.70210
D. Sudhadevi, P. Jayamurugan, S. Deivanayaki, Yogeswari Balasubramaniam, V. Gopala Krishnan, G. Umadevi, B. Suresh, Raman Rajeshkumar, A. ArunKumar, R. Bakkiyaraj, Ghazala Muteeb, Mohanbabu Bharathi

Nanocomposite materials that combine metal oxides with conducting polymers are increasingly explored for multifunctional biomedical applications. Cerium oxide (CeO) nanoparticles exhibit strong redox activity and reactive oxygen species (ROS) modulation, while polyaniline (PANI) offers high electrical conductivity and biocompatibility. Integrating these two materials can potentially yield composites with improved antibacterial and anticancer performance through enhanced charge transfer and ROS generation. In this study, PANI/CeO nanocomposites were synthesized by chemical polymerization and investigated for their structural, optical and biological characteristics. The composites were prepared with different weight percentages of CeO, such as 20%, 40%, 60%, and 80%. FTIR analysis confirmed the presence of Ce–O vibrations in the composite matrix. UV–visible absorption spectra showed a shift toward lower wavelengths. The calculated band gap values were 3.2, 3.1, 3.0, and 2.9 eV, based on CeO content. XRD analysis showed a preferred growth along the (111) plane, which indicated the cubic fluorite structure of CeO. The EDAX results confirmed the presence of cerium, oxygen, and carbon in the prepared samples. FE-SEM images showed spherical morphology with CeO well dispersed in the PANI matrix. The I–V measurements revealed non-linear characteristics with an increase in CeO concentration. The antibacterial activity increased against both Staphylococcus aureus and Pseudomonas aeruginosa with higher CeO content. The 80 wt% CeO composites showed the highest inhibition zone of 22 mm. This same composite showed a strong cytotoxic effect on HCT-116 colon cancer cells with an IC₅₀ value of 15.54 μg/mL. PL spectra revealed a broad emission band due to surface defects and a blue peak at 452 nm. The SAED pattern confirmed the crystalline nature of CeO with cubic symmetry.

将金属氧化物与导电聚合物相结合的纳米复合材料在多功能生物医学领域的应用越来越广泛。氧化铈(CeO)纳米颗粒具有很强的氧化还原活性和活性氧(ROS)调节能力,而聚苯胺(PANI)纳米颗粒具有高导电性和生物相容性。将这两种材料整合在一起,可以通过增强电荷转移和ROS的产生,获得具有更好抗菌和抗癌性能的复合材料。本研究采用化学聚合法制备了聚苯胺/CeO纳米复合材料,并对其结构、光学和生物学特性进行了研究。分别以20%、40%、60%、80%的CeO质量分数制备复合材料。FTIR分析证实复合材料基体中存在Ce-O振动。紫外可见吸收光谱向低波长偏移。根据不同的CeO含量,计算出的带隙值分别为3.2、3.1、3.0和2.9 eV。XRD分析表明,CeO沿(111)平面优先生长,表明其为立方萤石结构。EDAX结果证实了制备样品中铈、氧和碳的存在。FE-SEM图像显示为球形形貌,CeO在聚苯胺基体中分散良好。随着CeO浓度的增加,I-V测量显示出非线性特征。对金黄色葡萄球菌和铜绿假单胞菌的抑菌活性随着CeO含量的增加而增强。80 wt%的CeO复合材料的最大缓蚀带为22 mm。这种复合材料对HCT-116结肠癌细胞显示出很强的细胞毒性作用,IC₅₀值为15.54 μg/mL。由于表面缺陷,发光光谱显示出较宽的发射带,在452nm处有一个蓝色峰。SAED模式证实了CeO具有立方对称的结晶性质。
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引用次数: 0
Investigation of the Effects and Optimization Mechanisms of Taxus Powder on Poly(Butylene Adipate-co-Terephthalate)/Polylactic Acid Blend Properties 红豆杉粉对聚己二酸丁二酯/聚乳酸共混性能的影响及优化机理研究
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-29 DOI: 10.1002/app.70276
Haojun Jiang, Chen Chen, Feifei Wang, Dangdang Cheng, Yang Wang

In this study, micron-sized Taxus powder (TP) was prepared by fine grinding using Taxol-extracted Taxus residue as the raw material, and poly(butylene adipate-co-terephthalate) (PBAT)/polylactic acid (PLA)/TP bio-based composites were subsequently fabricated via melt blending. The influence of TP on the rheological, mechanical, thermal, and functional properties of PBAT/PLA blends was systematically investigated. The results show that TP improves melt-processing behavior and modifies the thermal degradation characteristics of the blends. At low to moderate TP loadings, the elongation at break remains above 200%, while higher TP contents lead to a progressive decline in mechanical performance. Notably, the incorporation of TP induces a gradual transition from hydrophobic to hydrophilic surface behavior, as reflected by a decreasing water contact angle, and significantly accelerates biodegradation. TP also introduces mild but measurable antibacterial activity against Escherichia coli and Staphylococcus aureus . Furthermore, when combined with a nano zinc surface coating, the composites exhibit markedly enhanced antibacterial efficiency through a synergistic surface-mediated effect. This work demonstrates the high-value utilization of Taxus residue as a functional filler and provides an effective strategy for developing biodegradable polymer composites with tunable processing, environmental responsiveness, and antibacterial performance for packaging-related applications.

本研究以紫杉醇提取的红豆杉渣为原料,通过细磨法制备微米级红豆杉粉(TP),然后通过熔融共混制备聚己二酸丁二酯(PBAT)/聚乳酸(PLA)/TP生物基复合材料。系统研究了TP对PBAT/PLA共混物流变学、力学、热性能和功能性能的影响。结果表明,TP改善了共混物的熔融加工行为,改变了共混物的热降解特性。在低至中等TP负荷下,断裂伸长率保持在200%以上,而较高的TP含量导致机械性能逐渐下降。值得注意的是,TP的掺入诱导了从疏水到亲水的表面行为逐渐转变,表现为水接触角的减小,并显著加速了生物降解。TP对大肠杆菌和金黄色葡萄球菌也有轻微但可测量的抗菌活性。此外,当与纳米锌表面涂层结合时,复合材料通过协同表面介导效应显着增强了抗菌效率。这项工作证明了红豆杉渣作为功能性填料的高价值利用,并为开发具有可调加工,环境响应性和抗菌性能的可生物降解聚合物复合材料提供了有效的策略,用于包装相关应用。
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引用次数: 0
Spiny Sea Cucumber-Like Cu@Fe3O4/PANI Hybrid as Electrode Materials for High-Performance Flexible Supercapacitors 棘海参样Cu@Fe3O4/聚苯胺混合材料作为高性能柔性超级电容器的电极材料
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-29 DOI: 10.1002/app.70268
Jie Hu, Fangya Zhang, Yifei Pei, Junjie Liu, Qiyang Wang, Manqing Yan

Flexible supercapacitor devices are the core driving force for the development of advanced energy storage technology. In this paper, novel nano-Cu@Fe3O4 spheres were fabricated using a one-pot solvothermal method, and in situ chemical oxidative polymerization of aniline monomer was constructed on the nano-Cu@Fe3O4 surface. The positive nano-Cu@Fe3O4 electronically adsorbed negative ANI monomers and fabricated conductive Cu@Fe3O4/PANI Hybrids (CFP). Interestingly, the as-obtained CFP hybrids possess rich morphology, stable structure, and big surface area, and these CFP hybrids exhibit low solution resistance and good capacitive properties measured by electrochemical tests. Notably, the nano-Cu@Fe3O4 spheres induced generation of spiny sea cucumber-like CFP3, effectively improving uniform dispersion and showing the strong synergistic effect of magnetic nano-Cu@Fe3O4 and PANI. Especially, the specific capacitance of CFP3 was 869.57 F g−1 at 0.5 A g−1 and the capacitance retention was 85.3% from 0.5 to 10 A g−1. Then the flexible symmetric supercapacitor device was assembled with novel CFP3 as positive and negative electrodes using PVA/H2SO4 gel electrolyte, which had 156.67 F g−1 of specific capacitance at 0.5 A g−1 and 13.93 W h kg−1 of energy density at a power density of 100 W kg−1. Thus, CFP hybrids have the potential application as an efficient conductive polymer electrode material for advanced flexible supercapacitors devices.

柔性超级电容器器件是先进储能技术发展的核心驱动力。本文采用一锅溶剂热法制备了新型nano-Cu@Fe3O4微球,并在nano-Cu@Fe3O4表面进行了苯胺单体的原位化学氧化聚合。正极nano-Cu@Fe3O4电吸附负极ANI单体,制备导电Cu@Fe3O4/PANI杂化体(CFP)。有趣的是,所得到的CFP杂化物具有丰富的形貌、稳定的结构和大的比表面积,并且通过电化学测试表明这些CFP杂化物具有低的溶液电阻和良好的电容性能。值得注意的是,nano-Cu@Fe3O4球诱导生成了棘状海参样CFP3,有效地改善了分散均匀性,并表现出磁性nano-Cu@Fe3O4和聚苯胺的强协同效应。特别是在0.5 A g−1时,CFP3的比电容为869.57 F g−1,在0.5 ~ 10 A g−1时,电容保持率为85.3%。采用PVA/H2SO4凝胶电解质,以新型CFP3为正负极组装柔性对称超级电容器器件,该器件在0.5 A g−1时的比电容为156.67 F g−1,在功率密度为100 W kg−1时的能量密度为13.93 W h kg−1。因此,作为一种高效的导电聚合物电极材料,CFP复合材料在先进的柔性超级电容器器件中具有潜在的应用前景。
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引用次数: 0
Vector Decomposition-Based Model Linking Filler Orientation to Dynamic Network Kinetics: From Experiment to Theoretical Prediction 基于向量分解的连接填料取向与动态网络动力学的模型:从实验到理论预测
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-29 DOI: 10.1002/app.70274
Xin Wu, Ying Hu, Yan Li, Lin Zhou, Yan Kou, Xiuli Zhao, Mao Chen

Herein, we propose a strategy to spatially regulate dynamic bond exchange in epoxy vitrimer by introducing graphite flakes (GFs) fillers with multi-angle orientations (θ = 0°–90°). Through a hot-pressing-induced alignment technique, GFs were arranged in five angular configurations within a disulfide-based vitrimer matrix. Stress relaxation analysis revealed a bidirectional regulatory effect: as θ increased from 0° to 90°, the characteristic relaxation time (τ) at 180°C rose from 17.2 to 28.0 s, while the activation energy (E a ) decreased from 97.7 to 90.0 kJ/mol. By integrating vector decomposition and Arrhenius kinetics, we established a dual-exponential decay model linking sinθ to E a and τ, quantitatively describing orientation-dependent dynamics. This work pioneers the spatial manipulation of vitrimer network reconfiguration, offering a paradigm for anisotropic smart materials.

在此,我们提出了一种策略,通过引入多角度取向(θ = 0°-90°)的石墨薄片(GFs)填料来空间调节环氧玻璃体中的动态键交换。通过热压诱导对准技术,GFs在二硫化物基玻璃体基体中以五种角度排列。应力松弛分析表明,当θ从0°增加到90°时,180°C下的特征松弛时间(τ)从17.2 s增加到28.0 s,而活化能(ea)从97.7 kJ/mol降低到90.0 kJ/mol。通过整合矢量分解和Arrhenius动力学,我们建立了连接sinθ与ea和τ的双指数衰减模型,定量描述了取向依赖动力学。这项工作开创了玻璃体网络重构的空间操作,为各向异性智能材料提供了一个范例。
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引用次数: 0
Study on Adsorption Performance of Porous Hydrogel Prepared From Etherified Modified Cyclodextrin for Rhodamine B in Asphalt Pavement Sewage 醚化改性环糊精制备多孔水凝胶对沥青路面污水中罗丹明B的吸附性能研究
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-28 DOI: 10.1002/app.70272
Mengmeng Fan, Guo-Tian Liu

In response to the prominent problems of severe pollution and high difficulty in degradation of dye wastewater. AA monomers were used to construct a high-molecular-weight backbone. Chloroacetic acid was employed for etherification modification of cyclodextrin, introducing abundant -COOH groups onto its molecular skeleton. Further, MWCNT was incorporated as a reinforcing phase into the hydrogel system. The active sites on MWCNT surface form a synergistic adsorption effect with cyclodextrin cavities, significantly broadening the adsorption scope for organic dyes. The structure and morphology of the hydrogels were characterized by infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and x-ray diffractometer (XRD). Different adsorbent dosage, temperature, pH and time were studied. Adsorption properties of Rhodamine B (RhB) dye. The results show that the surface of this cyclodextrin-based porous hydrogel has a well-developed porous network structure. Compared with traditional adsorption materials (such as activated carbon, single cyclodextrin materials and ordinary hydrogels), it has the advantages of larger specific surface area, more abundant active functional groups and higher mass transfer efficiency, and the maximum adsorption capacity of RhB can reach 858.6113 mg/g under optimal conditions. The adsorption process accords with the quasi-second-order kinetic model and Langmuir isothermal model, and belongs to the spontaneous, entropy-increasing and endothermic process. Therefore, the prepared hydrogel adsorbent material possesses the advantages of easy regeneration and efficient reusability, and exhibits great application potential in the purification of RhB from asphalt pavement sewage.

针对染料废水污染严重、难降解的突出问题。用AA单体构建了高分子量的骨架。采用氯乙酸对环糊精进行醚化改性,在环糊精分子骨架上引入了丰富的-COOH基团。此外,MWCNT作为增强相加入到水凝胶体系中。MWCNT表面的活性位点与环糊精腔形成协同吸附效应,显著拓宽了对有机染料的吸附范围。采用红外光谱(FT-IR)、扫描电镜(SEM)和x射线衍射仪(XRD)对水凝胶的结构和形貌进行了表征。研究了不同吸附剂用量、温度、pH和时间。罗丹明B染料的吸附性能。结果表明,该环糊精基多孔水凝胶表面具有发育良好的多孔网络结构。与传统吸附材料(如活性炭、单环糊精材料和普通水凝胶)相比,具有比表面积更大、活性官能团更丰富、传质效率更高的优点,在最优条件下对RhB的最大吸附量可达858.6113 mg/g。吸附过程符合准二级动力学模型和Langmuir等温模型,属于自发增熵吸热过程。因此,制备的水凝胶吸附材料具有易于再生和高效重复利用的优点,在净化沥青路面污水中RhB方面具有很大的应用潜力。
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引用次数: 0
Polylactide-Based Materials for Drug Delivery System: A Review 聚乳酸基给药材料研究进展
IF 2.8 3区 化学 Q2 POLYMER SCIENCE Pub Date : 2025-12-27 DOI: 10.1002/app.70245
Rike Tri Kumala Dewi, Ihsan Iswaldi, Purba Purnama, Andre Irwansah Samosir, Muhammad Samsuri, Paweł Sega, Lina Jaya Diguna, Muhammad Danang Birowosuto

Polylactide (PLA) is one of the potential materials in drug delivery systems (DDS). Biodegradability and biocompatibility are the advantages of PLA in DDS and other biomedical applications. Drug loading capacity, controlled drug release, and physical and mechanical properties are some critical requirements of materials for DDS. Additionally, the biological interactions of PLA, including its enzymatic hydrolysis, degradation into lactic acid, and subsequent metabolism through natural pathways, are essential for ensuring safe and efficient drug delivery. PLA-based materials have the capabilities to be developed into various advanced materials to overcome their limitations in physical and mechanical properties, such as PLA nanocomposites, PLA-copolymers, and stereocomplex PLA. Meanwhile, the hydrophobic character of PLA-based materials is a main challenge in drug delivery applications. This review highlights recent advances in PLA-based materials for DDS, focusing on material development, structure modification, and applications. Moreover, this review addresses the molecular modification and its relationship to tunable properties as potential next-generation bio-based polymeric materials for DDS.

聚乳酸(PLA)是一种极具潜力的给药材料。生物可降解性和生物相容性是聚乳酸在DDS和其他生物医学应用中的优势。载药能力、药物控释和物理力学性能是DDS材料的一些关键要求。此外,PLA的生物相互作用,包括其酶解、降解为乳酸以及随后通过自然途径的代谢,对于确保安全有效的给药至关重要。PLA基材料有能力发展成为各种先进材料,以克服其在物理和机械性能上的局限性,如PLA纳米复合材料、PLA共聚物和立体复合PLA。同时,pla基材料的疏水性是药物传递应用的主要挑战。本文综述了聚乳酸基DDS材料的最新进展,重点介绍了材料的发展、结构改性和应用。此外,本文综述了分子修饰及其与可调性能的关系,作为潜在的下一代生物基聚合物DDS材料。
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引用次数: 0
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Journal of Applied Polymer Science
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