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2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro最新文献

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Massive-training artificial neural networks for CAD for detection of polyps in CT colonography: False-negative cases in a large multicenter clinical trial 用于CT结肠镜息肉检测的CAD大规模训练人工神经网络:一项大型多中心临床试验中的假阴性病例
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541088
Kenji Suzuki, Mark L. Epstein, Ivan Sheu, R. Kohlbrenner, D. Rockey, A. Dachman
A major challenge in computer-aided detection (CAD) of polyps in CT colonography (CTC) is the detection of "difficult" polyps which radiologists are likely to miss. Our purpose was to develop massive-training artificial neural networks (MTANNs) for improving the performance of a CAD scheme on false-negative cases in a large multicenter clinical trial. We developed 3D MTANNs designed to differentiate between polyps and several types of non- polyps and tested on 14 polyps/masses that were actually "missed" by radiologists in the trial. Our initial CAD scheme detected 71.4% of "missed" polyps with 18.9 false positives (FPs) per case. The MTANNs removed 75% of the FPs without loss of any true positives; thus, the performance of our CAD scheme was improved to 4.8 FPs per case at the sensitivity of 71.4% of the polyps "missed" by radiologists.
CT结肠镜(CTC)中息肉的计算机辅助检测(CAD)的一个主要挑战是检测放射科医生可能错过的“困难”息肉。我们的目的是开发大规模训练的人工神经网络(mtann),以提高CAD方案在大型多中心临床试验中假阴性病例的性能。我们开发了3D mtann,旨在区分息肉和几种类型的非息肉,并在14个息肉/肿块上进行了测试,这些息肉/肿块实际上是在试验中被放射科医生“遗漏”的。我们最初的CAD方案检测出71.4%的“漏诊”息肉,每例18.9例假阳性(FPs)。mtann在不损失任何真阳性的情况下去除75%的FPs;因此,我们的CAD方案的性能提高到每例4.8 FPs,敏感度为71.4%的息肉被放射科医生“遗漏”。
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引用次数: 2
A statistical learning appproach to vertebra detection and segmentation from spinal MRI 基于统计学习的脊柱MRI椎体检测与分割方法
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4540948
Szu-Hao Huang, S. Lai, C. Novak
Automatically extracting vertebra regions from a spinal magnetic resonance image is normally required as the first step to an intelligent spinal MR image diagnosis system. In this work, we develop a fully automatic vertebra detection and segmentation method. Our system consists of three stages; namely, AdaBoost-based vertebra detection, detection refinement via robust curve fitting, and vertebra segmentation by an iterative normalized cut algorithm. We proposed an efficient and effective vertebra detector, which is trained by the improved AdaBoost algorithm, to locate the initial vertebra positions. Then, a robust estimation procedure is applied to fit all the vertebrae as a polynomial spinal curve to refine the vertebra detection results. Finally, an iterative segmentation algorithm based on normalized-cut energy minimization is applied to extract the precise vertebra regions from the detected windows. The experimental results show our system can achieve high accuracy on a number of testing 3D spinal MRI data sets.
从脊柱磁共振图像中自动提取椎体区域通常是智能脊柱磁共振图像诊断系统的第一步。在这项工作中,我们开发了一种全自动的椎体检测和分割方法。我们的制度包括三个阶段;即基于adaboost的椎体检测,通过鲁棒曲线拟合进行检测细化,通过迭代归一化切割算法进行椎体分割。我们提出了一种高效的椎体检测器,该检测器通过改进的AdaBoost算法训练来定位初始椎体位置。然后,应用鲁棒估计程序将所有椎体拟合为多项式脊柱曲线,以改进椎体检测结果。最后,采用一种基于归一化切割能量最小化的迭代分割算法,从检测窗口中提取精确的椎体区域。实验结果表明,该系统可以在多个测试的三维脊柱MRI数据集上达到较高的精度。
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引用次数: 10
Deformable registration with spatially varying degrees of freedom constraints 具有空间变化自由度约束的可变形配准
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541208
James V. Miller, Girish Gopalakrishnan, M. Datar, Paulo R. S. Mendonça, R. Mullick
Intra-subject deformable registration applications, such as longitudinal analysis and multi-modal imaging, use a high degree freedom deformation to accurately align soft tissue. However, smoothness constraints applied to the deformation and insufficient degrees of freedom in the deformation may distort the more rigid tissue types such as bone. In this paper, we present a technique that aligns rigid structures using rigid constraints while aligning soft tissue with a high degree of freedom deformation.
受试者内部可变形配准应用,如纵向分析和多模态成像,使用高度自由变形来精确对准软组织。然而,应用于变形的平滑性约束和变形中的自由度不足可能会扭曲更刚性的组织类型,如骨。在本文中,我们提出了一种使用刚性约束对齐刚性结构的技术,同时对齐具有高度自由变形的软组织。
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引用次数: 7
Geometry-driven visualization of microscopic structures in biology 生物学中微观结构的几何驱动可视化
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541124
K. Mosaliganti, R. Machiraju, Kun Huang
There are natural geometric patterns in biology. Tissue layers, for example, differ mainly in the spatial distributions, size and packing of microstructure components such as the red blood cells, nuclei and cytoplasm etc. Expressive visualization by using the N-point correlation functions, involves the discovery of feature spaces that estimate and spatially delineate component distributions unique to a salient tissue. These functions provide feature spaces that are used to set useful transfer functions. We obtain insightful 3D visualizations of the epithelial cell lining in mouse mammary ducts and evolving structures in a zebrafish embryo. These are large datasets acquired from light and confocal microscopy scanners respectively.
生物学中有天然的几何模式。例如,组织层的差异主要体现在红细胞、细胞核、细胞质等微结构成分的空间分布、大小和排列。通过使用n点相关函数,表达可视化涉及发现特征空间,这些特征空间可以估计和空间描绘显著组织特有的成分分布。这些函数提供用于设置有用传递函数的特征空间。我们获得了小鼠乳腺导管上皮细胞衬里和斑马鱼胚胎中进化结构的深刻的三维可视化。这些是分别从光学和共聚焦显微镜扫描仪获得的大数据集。
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引用次数: 1
Time-resolved cardiac CT reconstruction using the ensemble Kalman Filter 基于集合卡尔曼滤波的时间分辨心脏CT重建
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541290
A. George, M. Butala, R. Frazin, F. Kamalabadi, Y. Bresler
We propose an algorithm to solve the problem of Time-Resolved Cardiac Computed Tomography (CT). The algorithm reconstructs a snapshot of the moving heart at any time instant from CT projection data acquired over a single heart-cycle. The object is modeled by a spatio-temporal state-space model, and an ensemble Kalman Filter (a Monte-Carlo approximation to the Kalman filter) is used to assimilate the sequentially acquired projection data. Simulation results of the dynamic NCAT cardiac phantom, under the fan-beam geometry and a two-source CT system, show reconstructions that are free of the motion artifacts that mar conventional methods.
提出了一种解决时间分辨心脏计算机断层扫描(CT)问题的算法。该算法根据在单个心脏周期内获得的CT投影数据,在任意时刻重建运动心脏的快照。该方法采用时空状态空间模型对目标进行建模,并使用集合卡尔曼滤波器(一种近似卡尔曼滤波器的蒙特卡罗逼近法)对序列获取的投影数据进行同化。在扇形波束几何形状和双源CT系统下,动态NCAT心脏幻像的仿真结果显示,重建结果没有传统方法中存在的运动伪影。
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引用次数: 8
A fast parallel method for medical imaging problems including linear inequality constraints 包含线性不等式约束的医学成像问题的快速并行方法
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541074
Thomas D. Capricelli
When studying problems such as tomography with bounded noise or IMRT, we need to solve systems with many linear inequality constraints. Projection-based algorithms are often used to solve this kind of problem. We see how previous work for accelerating the convergence of linear algorithms can be recast within the most recent generic framework, and show that it gives better results in specific cases. The proposed algorithm allows general convex constraints as well and the conditions for convergence are less restrictive than tradition- nal algorithms. We provide numerical results carried out in the context of tomography and IMRT.
在研究有界噪声层析成像或IMRT等问题时,我们需要求解具有许多线性不等式约束的系统。基于投影的算法通常用于解决这类问题。我们看到以前的工作是如何加速线性算法的收敛,可以在最新的通用框架中重塑,并表明它在特定情况下给出了更好的结果。该算法允许一般的凸约束,收敛条件比传统算法约束少。我们提供了在断层扫描和IMRT的背景下进行的数值结果。
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引用次数: 0
Effect of the blood function error on the estimated kinetic parameters with dynamic pet 血功能误差对动态pet估计动力学参数的影响
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541314
Yafang Cheng, I. Yetik
PET is an imaging modality widely used in areas such as oncology, neurology, cardiology and neuropsychology/cognitive neuro-science. Dynamic PET, in contrast to static PET, can identify temporal variations in the radiotracer concentration. Mathematical modeling of the tissue of interest in dynamic PET can be simplified using compartment models as a linear system where the time activity curve of a specific tissue is the convolution of the tracer concentration in the plasma and the impulse response of the tissue containing kinetic parameters. Since the arterial sampling of blood to acquire the value of the tracer concentration is invasive, blind identification to estimate both the blood input function and the kinetic parameters has recently drawn attention. Several methods have been developed for this purpose, but the effect of the estimated blood on the estimation of the kinetic parameters is not studied. In this paper, we present a mathematical model to compute the error in the kinetic parameter estimates caused by the error in estimation of the blood input function. Computer simulations show that analytical expressions we derive are sufficiently close to results obtained from optimization. Our findings are conceptually important to observe the effect of the blood function on kinetic parameter estimation, but also practically useful to evaluate various blind methods.
PET是一种广泛应用于肿瘤学、神经学、心脏病学和神经心理学/认知神经科学等领域的成像方式。与静态PET相比,动态PET可以识别放射性示踪剂浓度的时间变化。动态PET中感兴趣组织的数学建模可以使用室模型作为线性系统来简化,其中特定组织的时间活度曲线是等离子体中示踪剂浓度和包含动力学参数的组织的脉冲响应的卷积。由于动脉采血获取示踪剂浓度值是一种有创性的方法,因此同时估计血液输入函数和动力学参数的盲识别方法近年来受到人们的关注。为此已经开发了几种方法,但尚未研究估计的血液对动力学参数估计的影响。在本文中,我们提出了一个数学模型来计算由血液输入函数估计误差引起的动力学参数估计误差。计算机模拟表明,我们得到的解析表达式与优化得到的结果非常接近。我们的发现对于观察血液功能对动力学参数估计的影响具有重要的概念意义,但对于评估各种盲法也具有实际意义。
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引用次数: 2
New techniques for data fusion in multimodal FMT-CT imaging 多模态FMT-CT成像数据融合新技术
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541317
Damon E. Hyde, E. Miller, D. Brooks, V. Ntziachristos
We examine approaches to the incorporation of anatomic structural information into the inverse problem of fluorescence molecular tomography (FMT). Using an appropriate relationship between anatomic and reconstruction image resolution, we build an inverse problem parameterized along the anatomical segmentation. These values serve as the basis for two new regularization techniques. The first regularizes individual voxels in proportion to the importance of the underlying segments in reducing the residual error. The second is based on a well known statistical interpretation of Tikhonov-type regularization in which the statistical prior is defined implicitly as the solution to a PDE whose structure is based on the anatomical segmentation. Results are shown using both techniques for a simulated experiment within the chest cavity of a mouse.
我们研究了将解剖结构信息纳入荧光分子断层扫描(FMT)反问题的方法。利用解剖和重建图像分辨率之间的适当关系,我们建立了沿解剖分割参数化的逆问题。这些值是两种新的正则化技术的基础。第一种方法是对单个体素进行正则化,使其与底层段的重要性成比例,从而减少残差。第二种是基于众所周知的吉洪诺夫型正则化的统计解释,其中统计先验被隐式定义为PDE的解决方案,其结构基于解剖分割。结果显示了使用这两种技术在小鼠胸腔内的模拟实验。
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引用次数: 9
Promising results for early diagnosis of lung cancer 肺癌早期诊断的可喜结果
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541205
A. El-Baz, G. Gimel'farb, R. Falk, M. El-Ghar, H. Refaie
Our long term research goal is to develop a fully automated, image- based diagnostic system for early diagnosis of pulmonary nodules that may lead to lung cancer. This paper focuses on monitoring the development of lung nodules detected in successive chest low dose (LD) CT scans of a patient. We propose a new methodology for 3D LDCT data registration which is non-rigid and involves two steps: (i) global alignment of one scan (target) to another scan (reference or prototype) using the learned prior appearance model followed by (ii) local alignment in order to correct for intricate deformations. After equalizing signals for two subsequent chest scans, visual appearance of these chest images is modeled with a Markov-Gibbs random field with pairwise interaction. We estimate the affine transformation that globally register the target to the prototype by gradient descent maximization of a special Gibbs energy function. To handle local deformations, we deform each voxel of the target over evolving closed equi-spaced surfaces (iso-surfaces) to closely match the prototype. The evolution of the iso-surfaces is guided by an exponential speed function in the directions that minimize distances between the corresponding voxel pairs on the iso-surfaces in both the data sets. Preliminary results on the 135 LDCT data sets from 27 patients show that our proper registration could lead to precise diagnosis and identification of the development of the detected pulmonary nodules.
我们的长期研究目标是开发一种全自动的、基于图像的诊断系统,用于早期诊断可能导致肺癌的肺结节。本文的重点是监测在连续胸部低剂量(LD) CT扫描中发现的肺结节的发展。我们提出了一种用于3D LDCT数据配准的新方法,该方法是非刚性的,涉及两个步骤:(i)使用学习的先验外观模型将一个扫描(目标)全局对齐到另一个扫描(参考或原型),然后(ii)局部对齐以纠正复杂的变形。在对随后两次胸部扫描的信号进行均衡化后,这些胸部图像的视觉外观用具有两两相互作用的马尔可夫-吉布斯随机场建模。我们通过一个特殊的Gibbs能量函数的梯度下降最大化来估计将目标全局注册到原型的仿射变换。为了处理局部变形,我们在进化的封闭等间距表面(iso-surfaces)上变形目标的每个体素,以紧密匹配原型。在两个数据集中,等值面的演化由指数速度函数引导,其方向是使等值面的对应体素对之间的距离最小。来自27例患者的135个LDCT数据集的初步结果表明,我们正确的登记可以导致准确的诊断和识别检测到的肺结节的发展。
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引用次数: 23
Fast parallel image reconstruction using smacker for functional magnetic resonance imaging 基于smacker的功能磁共振成像快速并行图像重建
Pub Date : 2008-05-14 DOI: 10.1109/ISBI.2008.4541058
Q. Tieng, V. Vegh, G. Cowin, Zhengyi Yang
SMACKER is a method of calculating sensitivity maps from k-space reconstruction coefficients using only a few lines of inner k-space. In this method the problem of sensitivities ending at object boundaries is eliminated, unlike in other established methods. The method allows for the rapid calculation of sensitivity profiles from images, and it is proposed here that the approach can be used in functional MRI to obtain reconstructed images in little time. Functional MRI relying on fast parallel reconstruction techniques naturally lends itself to a method that can generate and use sensitivity maps directly from images.
SMACKER是一种从k空间重构系数计算灵敏度映射的方法,仅使用k空间内部的几行。该方法消除了灵敏度在目标边界处结束的问题。该方法可以从图像中快速计算灵敏度分布,并且在这里提出该方法可以用于功能MRI,以便在短时间内获得重建图像。依靠快速并行重建技术的功能性MRI自然有助于直接从图像中生成和使用灵敏度图。
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引用次数: 2
期刊
2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro
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