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VEGF and Cervical Cancer Stage IB – IIA Response after Chemotherapy with Ifosfamide – Cisplatin 异环磷酰胺-顺铂化疗后VEGF与宫颈癌IB - IIA期疗效的关系
Pub Date : 2019-09-30 DOI: 10.32734/SUMEJ.V2I3.1231
D. Edianto
The aim of this study is to evaluate response of cervical cancer stage IB – IIA after neoadjuvant chemotherapy based on VEGF expression. The data were collected from 51 patients’ cervical cancer stage IB – IIA parafin blocks who received chemotherapy ifosfamide – cisplatin before radical hysterectomy at General Hospital Adam Malik Medan. VEGF expression was evaluated from cervical biopsy tissue, and response therapy was evaluated based on tumor size clinically. 20 out of 51 samples with clinically complete response, and the rest are partial response. 18 out of 20 samples with clinically complete response have negative or weak VEGF expression, and 31 out of 51 samples patients were partialy response with moderate or strong VEGF expression. 23 cases with tumor size > 4 cm and 23 cases stage IIA expressed VEGF moderately or strong. Cervical cancer with tumor size < 4 cm and cervical cenncer stage IB with less expressed of VEGF have good response with chemotherapy adjuvant ifosfamide – cis platin.Keyword: ifosfamide-cisplatin, cervical cancer, VEGF
本研究的目的是基于VEGF表达评价宫颈癌IB - IIA期新辅助化疗后的疗效。数据收集自51例宫颈癌IB - IIA期石蜡阻滞患者,这些患者在根治性子宫切除术前接受了异环酰胺-顺铂化疗。从宫颈活检组织中评估VEGF表达,并根据临床肿瘤大小评估反应治疗。51个样本中有20个临床完全缓解,其余为部分缓解。20例临床完全缓解的患者中有18例VEGF表达阴性或弱,51例患者中有31例VEGF表达中度或强,部分缓解。肿瘤大小> 4cm者23例,IIA期者23例,VEGF中、强表达。肿瘤大小< 4cm的宫颈癌和VEGF表达较少的IB期宫颈癌,化疗辅助异环磷酰胺顺式铂疗效较好。关键词:异环磷酰胺顺铂,宫颈癌,VEGF
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引用次数: 0
Description of Pregnant Women's Nutritional Status Based on The Mid-Upper Arm Circumference in Sundari Medan General Hospital In 2019 基于中上臂围的2019年棉兰总医院孕妇营养状况描述
Pub Date : 2019-09-17 DOI: 10.32734/sumej.v3i3.3309
David Franli, M. Sitepu, H. P. Pasaribu, S. J. Martina
Introduction. Chronic energy deficieny (CED) is a condition of a body characterized by low body weight and low energy stores, possibly limited physical capacity due to deprivation of food over a long period time. Ministry of Health ( Kemenkes) showed that in 2015, 305 out of 100.000 death of pregnant women is realated to malnutriotion and CED. Objective. The aim of this study is to determine the overview of pregnant women nutritional status based on mid-upper arm circumference (MUAC) in Sundari Medan General Hospital. Method. The study was an observational descriptive study with a cross sectional design. The samples of this study consists of pregnant women from Sundari Medan Genaral Hospital, who had fulilled the inclusion and esclusion criteria by total sampling. Results.. Among 60 samples, the prevalance of Non-CED woman (85%) was found higher than the mild malnutrition (15%). Conclusion. Prevalance of CED pregnant women was found higher in risky age, middle educated and high income family.  
介绍。慢性能量缺乏症(Chronic energy deficiency, CED)是一种以低体重和低能量储存为特征的身体状态,可能是由于长期缺乏食物而导致的身体能力受限。卫生部(Kemenkes)显示,2015年,10万名孕妇死亡中有305人与营养不良和腹泻有关。目标。本研究的目的是基于中上臂围(MUAC)确定在Sundari棉兰总医院孕妇营养状况的概述。方法。本研究为横断面设计的观察性描述性研究。本研究的样本由Sundari Medan总医院的孕妇组成,通过总抽样符合纳入和排除标准。结果. .在60个样本中,非ced女性的患病率(85%)高于轻度营养不良(15%)。结论。在高危年龄、中等文化程度和高收入家庭中,CED的患病率较高。
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引用次数: 0
Factors Influencing the Decision of Parents to LP in Pediatric with CNS Infection 影响中枢神经系统感染患儿家长选择LP的因素
Pub Date : 2019-09-17 DOI: 10.32734/sumej.v2i3.1262
Dessy Dian Antarini, Y. Dimyati, Nelly Rosdiana, I. Fujiati, Cynthea Prima Destariani
Lumbal Puncture (LP) is a procedure that can help to diagnosed CNS infection in children. The procedure of LP is a common invasive procedure, but sometimes it had refused by the parents. Furthermore, it can cause a delayed in the diagnosis and affected the prognosis. The subject was the parents of pediatric patients with CNS infection. We have a questionnaire and using Chi-square and Fisher exact test to analyze factors that influenced the parent’s decision of LP procedure. From the parents of 50 children with CNS infection, 19 parents (38%) were refused the LP procedure. Father’s education was related to the refusal of LP procedure with PR 6.64 (95%CI; 8.95-788.08). Mother’s education was related to the refusal of LP procedure with PR 7.69 (95%CI; 3.19-16.24). There was the significant result of the parent's education with the decision of LP procedure.
腰椎穿刺(LP)是一种可以帮助诊断儿童中枢神经系统感染的方法。LP手术是一种常见的侵入性手术,但有时会遭到家长的拒绝。此外,它可能导致诊断延误,影响预后。研究对象为小儿中枢神经系统感染患者的家长。我们通过问卷调查,运用卡方检验和Fisher精确检验来分析影响家长选择LP治疗的因素。在50例中枢神经系统感染患儿家长中,有19例(38%)家长拒绝行LP手术。父亲受教育程度与拒绝LP手术相关,PR为6.64 (95%CI;8.95 - -788.08)。母亲受教育程度与拒绝LP手术相关,PR为7.69 (95%CI;3.19 - -16.24)。选择LP手术后,家长的教育效果显著。
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引用次数: 0
The Relationship between Obstructive Sleep Apnea (OSA) and Adherence of Antihypertensive Consumption in Regular Hemodialysis Patient 血液透析患者阻塞性睡眠呼吸暂停(OSA)与降压消费依从性的关系
Pub Date : 2019-08-20 DOI: 10.32734/SUMEJ.V2I2.758
Afrilia Rosada Lubis, R. Muzasti
Background. Based on the Indonesian Renal Registry (IRR) data in 2015, the highest incidence of comorbidities in hemodialysis patients in Indonesia was hypertension (50%). Obstructive Sleep Apnea (OSA) is one of the causes of secondary hypertension, the characteristics of hypertension in OSA are more resistant to treatment. One of the causes of resistant hypertension is patient non-compliance with the consumption of antihypertensive drugs. Aim. To determine the relationship of adherence of consumption of antihypertensive drugs with obstructive sleep apnea in regular HD patients. Method. This cross-sectional study involved 89 outpatients in HD units at the Rasyida Kidney Hospital in 2018. Data was obtained through interview using the STOP-BANG questionnaire to assess the of risk of OSA and using Morisky Medication Adherence Scale (MMAS) questionnaire to measure the compliance of  drug consumption. Results.The prevalence of OSA  in HD patients was (39.3%). There was no significant relationship between adherence with drug consumption and OSA risk, but in bivariate analysis, age (p = 0.0001), body mass index (BMI) (p = 0.001), and gender (p = 0.03) were significantly related to OSA. In multivariate, age and BMI were significantly associated with OSA (OR: 6.449, 95% CI 2.246 ± 18.520, p = 0.001; OR: 6.130, 95% CI 2.105 ± 17.849, p = 0.001). Conclusion. OSA was not statistically related to adherence to antihypertensive drug consumption in HD patients but was significantly associated with age and BMI.     Keyword. Adherence to antihypertensive consumption, hemodialysis, obstructive sleep apnea.
背景。根据印度尼西亚肾脏登记处(IRR) 2015年的数据,印度尼西亚血液透析患者的合并症发病率最高的是高血压(50%)。阻塞性睡眠呼吸暂停(OSA)是继发性高血压的病因之一,OSA的高血压特点更难以治疗。顽固性高血压的原因之一是患者不遵医嘱服用降压药。的目标。目的:探讨高血压病患者抗高血压药物依从性与阻塞性睡眠呼吸暂停的关系。方法。这项横断面研究涉及2018年Rasyida肾脏医院HD病房的89名门诊患者。访谈数据采用STOP-BANG问卷评估OSA风险,Morisky用药依从性量表(MMAS)问卷测量用药依从性。结果。HD患者的OSA患病率为(39.3%)。服药依从性与OSA风险无显著相关性,但在双变量分析中,年龄(p = 0.0001)、体重指数(BMI) (p = 0.001)和性别(p = 0.03)与OSA显著相关。在多变量中,年龄和BMI与OSA显著相关(OR: 6.449, 95% CI 2.246±18.520,p = 0.001;OR: 6.130, 95% CI 2.105±17.849,p = 0.001)。结论。OSA与HD患者抗高血压药物服用依从性无统计学相关性,但与年龄和BMI显著相关。关键字。坚持降压消费,血液透析,阻塞性睡眠呼吸暂停。
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引用次数: 0
The Relationship of Consumption Purin-rich foods to the incident of Hyperuricemia in the Elderly at Hisosu Nursing Home In Binjai 滨江县Hisosu养老院老年人高尿酸血症发生与食用富含嘌呤的食物的关系
Pub Date : 2019-08-17 DOI: 10.32734/sumej.v3i3.3322
Angrayni Putri Muselli, Z. Tala
Hyperuricemia is an increase in blood uric acid levels. In the elderly cell damage occurs due to the aging process which can result in organ weakness, physical damage and various diseases such as increased uric acid levels. The purpose of this study is to determine the relationship between purine intake and the incidence of hyperuricemia in the elderly at the HISOSU Binjai nursing home. This research was conducted with an observational analytic research design using a cross sectional study. Samples were selected using the total sampling method and adjusted for inclusion and exclusion criteria. Data taken by weighing and recording food (in 1 day) Then assess respondent uric acid levels. This is done 3 times in the HISOSU Binjai nursing home. There are 32 research samples. Samples that experienced hyperuricemia as much as 40.6%, most of them consuming moderate-category purine source protein. The results of the chi-square test Pearson chi-squared t-test was 16.453 and p value < 0.001 (<0.05), it can be concluded as consumption of purine source protein associated with the incidence of hyperuricemia. The higher the purine intake, the greater the chance of getting hyperuricemia.
高尿酸血症是指血尿酸水平升高。在老年人中,由于衰老过程导致细胞损伤,可能导致器官衰弱,身体损伤和各种疾病,如尿酸水平升高。本研究的目的是确定嘌呤摄入量与HISOSU滨江养老院老年人高尿酸血症发生率之间的关系。本研究采用观察性分析研究设计,采用横断面研究。采用全抽样方法选择样本,并根据纳入和排除标准进行调整。称重并记录食物(1天内)然后评估被调查者尿酸水平。在HISOSU binai养老院做了3次。共有32个研究样本。高尿酸血症的样本高达40.6%,其中大多数消耗中等类别嘌呤来源蛋白。卡方检验的结果Pearson卡方t检验为16.453且p值< 0.001(<0.05),可以得出结论,嘌呤源蛋白的摄入与高尿酸血症的发病率相关。嘌呤摄入量越高,患高尿酸血症的几率就越大。
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引用次数: 0
The Relationship of Knowledge, Attitude, and Behavior to Taking Care of External Genitalia with Leucorrhea Incident in The Darul Hikmah Islamic Boarding School Student Darul Hikmah伊斯兰寄宿学校学生外生殖器护理知识、态度和行为与白带事件的关系
Pub Date : 2019-08-17 DOI: 10.32734/SUMEJ.V3I3.3318
Khairina Zahra, D. Anggraini
Introduction. Reproduction organ is one of the sensitive organ in the body and need special care. Personal hygiene habit is one of the important factor to avoid infection. It is because infection can cause vaginal discharge and cervical carcinoma. Tropical climate in Indonesia lead about 90% of girl teenagers to potentially have vaginal discharge causing bacteria, fungi, and virus easily grow. Objectives. To identify the relationship between knowledge, attitude, and behavior of taking care of external genitalia with vaginal discharge incident on students at Pondok Pesantren Modern Darul Hikmah. Methods. This is a descriptive analytical study with cross sectional design. The data was taken with primary data. Results. Leucorrhoea incidence rate at 103 respondents are 60,2% of normal vaginal discharge and 38,9% of abnormal vaginal discharge. There is a correlation between knowledge of taking care of external genitalia with vaginal discharge (p=0,001). There is correlation between attitude of taking care of external genitalia with vaginal discharge (p=0,018). There is correlation between behavior of taking care of external genitalia with vaginal discharge (p=0,002). Conclusion. There is correlation between knowledge, attitude, and behavior of taking care of external genitalia with vaginal discharge incident on students at Pondok Pesantren Modern Darul Hikmah.
介绍。生殖器官是人体的敏感器官之一,需要特别照顾。个人卫生习惯是避免感染的重要因素之一。这是因为感染可引起阴道分泌物和宫颈癌。印度尼西亚的热带气候导致大约90%的少女可能有阴道分泌物,容易滋生细菌、真菌和病毒。目标。目的探讨本德私立私立学校学生外生殖器护理知识、态度和行为与阴道分泌物事件的关系。方法。这是一项采用横断面设计的描述性分析研究。该数据采用原始数据。结果。103名应答者的白带发生率为正常阴道分泌物的60.2%和异常阴道分泌物的38.9%。外生殖器护理知识与阴道分泌物之间存在相关性(p= 0.001)。护理外生殖器态度与阴道分泌物有相关性(p= 0.018)。护理外生殖器的行为与阴道分泌物有相关性(p= 0.002)。结论。Pondok Pesantren Modern Darul Hikmah学生外生殖器护理知识、态度及行为与阴道分泌物事件相关。
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引用次数: 0
Blastocytosis hominis: Unboxing Its Clinical Significance 人胚细胞增多症的临床意义
Pub Date : 2019-08-07 DOI: 10.32734/sumej.v2i2.724
M. Rozi, D. Darlan
Abstract. Blastocystis hominisis a unicellular parasite classified as stramenopiles found in human and other mammals. The prevalence varies depending on the region, higher in developing country. The organism is transmitted via fecal-oral route by ingestion of oocyst contaminated food or water. Travelers also have high-risk of having blastocytstis infection. Based on recent studies, several proposed virulence factor are also identified but it remains elusive. The advanced technique has been used to describe its genetic variation and diversity that might be related to its clinical significance. There are 6 distinct morphological forms of Blastocystis including vacuolar, granular, ameboid, and cystic form. The cystic form is considered as an infective form of the organism. Exposure to animals is suggested as the other transmission route, consequently, the infection is also considered as zoonotic infection. It can produce broad clinical manifestation ranging from asymptomatic, self-limiting diarrhea until severe watery diarrhea, depends on host factors and the organism subtype. The organism can produce pruritus and urticaria, proved in literature. Since its pathogenicity remains unclear, conservative management is still suggested to all asymptomatic-symptomatic blastocytosis patients in accordance to patient’s immune status.
摘要人胚囊虫:一种在人类和其他哺乳动物中发现的单细胞寄生虫。发病率因区域而异,在发展中国家较高。该病菌通过粪口途径通过摄入被卵囊污染的食物或水传播。旅行者也有感染囊胚炎的高风险。根据最近的研究,也确定了几个建议的毒力因子,但仍然难以捉摸。这项先进的技术已被用于描述其遗传变异和多样性,这可能与其临床意义有关。囊胚有6种不同的形态,包括液泡状、粒状、变形虫状和囊状。囊性病变被认为是一种感染性病变。与动物接触被认为是另一种传播途径,因此,该感染也被认为是人畜共患感染。其临床表现广泛,可由无症状、自限性腹泻直至严重水样腹泻,视乎宿主因素和机体亚型而定。文献证实,这种微生物可引起瘙痒和荨麻疹。由于其致病性尚不清楚,对于所有无症状的囊胚细胞增多症患者,仍建议根据患者的免疫状况进行保守治疗。
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引用次数: 0
Chronic Effect Various Type of Exercises to Fasting Blood Glucose and Insulin Resistance 不同类型运动对空腹血糖和胰岛素抵抗的慢性影响
Pub Date : 2019-06-01 DOI: 10.32734/SUMEJ.V2I2.1063
Y. Machrina, Ambrocious Purba, D. Lindarto, M. Daulay
Exercise is non-pharmacological management for Diabetes Mellitus (DM) type-2. Previous study found that both eerobic and interval training improved insulin resistance. The aim of this study was to analyze the chronic effect various type of exercises to fasting blood glucose (FBG) and insulin resistance in DM type-2 model rats. It was an experimental study, twenty male Wistar rats, age 8 weeks, weight 150-180 gram as the object. Rats were given high fed diet for 4 weeks then injected streptozocin dose 30 mg/kgBB in citrate buffer pH 4.5 i.p, and 45 mg/kgBB  at the following week. Groups were divided into i.e moderate continous training (MCT), severe continous training (SCT), slow interval training (SIT), and fast interval training (FIT). All groups were treated with ran on the treadmill three times a week for 8 weeks. Fasting blood glucose and fasting insulin were checked before and after intervention. Insulin resistance was determined by calculating HOMA-IR. Data analized with paired t-test (p<0,05). The results shown that all group significantly decreased fasting blood glucose and insulin resistance (p <0,05) after eight weeks exercise except insulin resistance in MCT group.  Fasting blood glucose and insulin resistence post-test was found lowest in SIT groups in this study.  In conclucions chronic effect of aerobic continous and aerobic interval in various intensity can decrease fasting blood glucose and insulin resistance in DM type-2 rat model. Slow interval training was the best exercise model to decrease insulin resistance.
运动是2型糖尿病(DM)的非药物治疗方法。先前的研究发现有氧运动和间歇训练都能改善胰岛素抵抗。本研究旨在分析不同类型运动对2型糖尿病模型大鼠空腹血糖和胰岛素抵抗的慢性影响。本实验以20只雄性Wistar大鼠为研究对象,年龄8周龄,体重150-180克。大鼠先饲喂高饲粮4周,然后在pH为4.5 i.p的柠檬酸缓冲液中注射链脲佐菌素30 mg/kgBB,第2周注射45 mg/kgBB。各组分为中度连续训练(MCT)、重度连续训练(SCT)、慢速间歇训练(SIT)和快速间歇训练(FIT)。所有组每周在跑步机上跑步3次,持续8周。干预前后分别检测空腹血糖和空腹胰岛素。通过计算HOMA-IR来确定胰岛素抵抗。数据采用配对t检验(p< 0.05)。结果表明,除MCT组胰岛素抵抗外,各组运动8周后空腹血糖和胰岛素抵抗均显著降低(p < 0.05)。在本研究中,SIT组的空腹血糖和胰岛素抵抗水平最低。综上所述,不同强度的连续有氧运动和间歇有氧运动具有降低2型糖尿病大鼠空腹血糖和胰岛素抵抗的慢性作用。慢速间歇训练是降低胰岛素抵抗的最佳运动模式。
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引用次数: 0
Profile of Teenage Pregnancy in H. Adam Malik Hospital Medan in 2011-2015 棉兰亚当马利克医院2011-2015年少女怀孕情况分析
Pub Date : 2019-06-01 DOI: 10.32734/SUMEJ.V2I2.1066
K. Sukatendel, Iman Helmi Effendi, Sarah Dina, S. A. Nasution, Johny Marpaung, I. Hamidi
Many of the teenagers who enter pregnancy would cause a decline in health and nutritional status. Delivery at an early age was associated with a greater health risk for the mother. To assess the profile of teenage pregnancy in H. Adam Malik Hospital Medan year 2011-2015. This study was conducted with descriptive study design using secondary data from medical records. There were 128 patients who became pregnant in their teens. Then the data were tabulated and presented in the form of frequency distribution table and were analyzed descriptively. Most pregnant women came to the hospital for parturition (60.1%) followed by preeclampsia / eclampsia (14.8%). The way of delivery of pregnant adolescent women was vaginal (52.3%) followed by cesarean (36.7%). There was no significant relationship between adolescent age of pregnant and newborn weight. There was no significant relationship between the age of the adolescent and method of delivery. Most teenage pregnancy occured between 17-19 years. Most pregnant teenagers delivered vaginally, and most of the newborns were normoweight
许多进入怀孕期的青少年会导致健康和营养状况下降。过早分娩对母亲的健康风险更大。目的评估棉兰亚当马利克医院2011-2015年少女怀孕情况。本研究采用描述性研究设计,使用来自医疗记录的二手数据。有128名患者在十几岁时怀孕。然后将数据以频率分布表的形式制成表格,并进行描述性分析。大多数孕妇来医院分娩(60.1%),其次是子痫前期/子痫(14.8%)。怀孕少女分娩方式以阴道分娩为主(52.3%),其次为剖宫产(36.7%)。青少年怀孕年龄与新生儿体重无显著关系。青少年年龄与分娩方式之间无显著关系。大多数少女怀孕发生在17-19岁之间。大多数怀孕的少女都是顺产,大多数新生儿体重正常
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引用次数: 0
Diagnostic Accuracy of Gene X-pert MTB/RIF for Tuberculous Pleural Effusion Compared to Adenosine Deaminase (ADA) at Haji Adam Malik General Hospital Medan 基因X-pert MTB/RIF对结核性胸腔积液与腺苷脱氨酶(ADA)诊断的准确性比较
Pub Date : 2019-06-01 DOI: 10.32734/SUMEJ.V2I2.1067
A. MuhammadZainul, Fajrinur Syahrani, P. Siagian, P. Eyanoer
Indonesia is one of the few countries in the world with very high burden of tuberculosis (TB). Tubercular pleural effusion (Pleural TB) is the most common form of extra-pulmonary TB, however the remains a common clinical challenge. This research from May 2017 through September 2017 a total of 42 patients with exudative lymphocytic pleural effusions suspected to pleural tuberculosis were enrolled in this study. Adenosine deaminase (ADA) and Gene X-pert were examined from pleural fluid. Diagnosis was made clinically or based from sputum/pleural fluid culture. The result of this research showed out of all participants, 64,3% (27/42) had ADA in positive level (>40 IU/L) and 31% (13/24) had Gene X-pert positive Mycobacterium Tb. The Gene X-pert sensitivity was 40.7% with specificity 86.6%, PPV and NPV were 44.8% and 57.1% respectively. Kappa Compatibility study show that Gene X-pert point was 0.227 (p 0.066). The usefulness of Gene X-pert to diagnose pleural TB is limited by its poor sensitivity.  Gene X-pert cannot be used as single diagnostic tool for tuberculous pleural effusion
印度尼西亚是世界上为数不多的结核病负担很高的国家之一。结核性胸腔积液(胸膜结核)是肺外结核最常见的形式,但仍然是一个常见的临床挑战。本研究于2017年5月至2017年9月共纳入42例疑似胸腔结核的渗出性淋巴细胞性胸腔积液患者。采用胸膜液检测腺苷脱氨酶(ADA)和基因X-pert。诊断依据临床或痰液/胸膜液培养。该研究结果显示,在所有参与者中,64.3%(27/42)的ADA呈阳性水平(>40 IU/L), 31%(13/24)的基因X-pert呈结核分枝杆菌阳性。基因X-pert敏感性为40.7%,特异性为86.6%,PPV和NPV分别为44.8%和57.1%。Kappa相容性研究显示基因X-pert点为0.227 (p 0.066)。基因X-pert诊断胸膜结核的有效性受到其敏感性差的限制。基因X-pert不能作为结核性胸腔积液的单一诊断工具
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引用次数: 1
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Sumatera Medical Journal
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