首页 > 最新文献

Sumatera Medical Journal最新文献

英文 中文
In Vitro Antimicrobial Activity of Bawang Batak Bulbs (Allium Chinense G. Don) Against Methicillin-Resistant Staphylococcus Aureus 霸王巴塔克球茎对耐甲氧西林金黄色葡萄球菌的体外抗菌活性研究
Pub Date : 2019-06-01 DOI: 10.32734/SUMEJ.V2I2.1065
Tiasarah Aretha, N. Jusuf
Introduction: Staphylococcus aureus infection can cause pyoderma. These days there is a shift in Staphylococcus aureus sensitivity to antibiotics that is marked by the existence of Methicillin-Resistant Staphyloccus aureus, so alternative therapy that is herbal medicine might be needed. There are a lot of medicinal plants in Indonesia, but until today the usage is still minimum. One of the plant genus that is already being used is allium that had been known to have antimicrobial activity. The genus allium that is consumed a lot by Indonesians especially people of North Sumatra is bawang batak (Allium chinense G.Don.). This study is conducted to assess the antimicrobial activity of bawang batak bulbs in several concentrations to MRSA. Methods: This research is an experimental research with agar diffusion method. The extracts were divided into six groups: extracts in concentration level of 6.25%, 12.5%, 25%, 50%, 100% and a negative control (DMSO). The sample size is four per group with total sample of 24. Results: The results showed that the inhibition of bacterial growth occured at the concentration levels of 50% and 100% with inhibition zone diameters of 8.695 mm and 10.545 mm respectively. Extracts with concentration levels of 25%, 12.5% and 6.25% did not show any inhibition. Conclusion: Bawang batak bulbs extract can be used to inhibit the growth of MRSA
简介:金黄色葡萄球菌感染可引起脓皮病。这些天来,金黄色葡萄球菌对抗生素的敏感性发生了变化,其标志是耐甲氧西林金黄色葡萄球菌的存在,因此可能需要草药替代疗法。印度尼西亚有很多药用植物,但直到今天使用量仍然很少。已经被使用的植物属之一是已知具有抗菌活性的葱属植物。印尼人特别是北苏门答腊岛人大量食用的葱属植物是巴旺巴塔克(allium chinense g.d don .)。研究了不同浓度霸王batak球茎对MRSA的抑菌活性。方法:本研究采用琼脂扩散法进行实验研究。将提取液分为6组:浓度水平为6.25%、12.5%、25%、50%、100%的提取液和阴性对照(DMSO)。样本数量为每组4个,总样本数量为24个。结果:结果表明,在浓度为50%和100%时,抑菌带直径分别为8.695 mm和10.545 mm;浓度为25%、12.5%和6.25%的提取物均无抑制作用。结论:霸王batak球茎提取物可抑制MRSA的生长
{"title":"In Vitro Antimicrobial Activity of Bawang Batak Bulbs (Allium Chinense G. Don) Against Methicillin-Resistant Staphylococcus Aureus","authors":"Tiasarah Aretha, N. Jusuf","doi":"10.32734/SUMEJ.V2I2.1065","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I2.1065","url":null,"abstract":"Introduction: Staphylococcus aureus infection can cause pyoderma. These days there is a shift in Staphylococcus aureus sensitivity to antibiotics that is marked by the existence of Methicillin-Resistant Staphyloccus aureus, so alternative therapy that is herbal medicine might be needed. There are a lot of medicinal plants in Indonesia, but until today the usage is still minimum. One of the plant genus that is already being used is allium that had been known to have antimicrobial activity. The genus allium that is consumed a lot by Indonesians especially people of North Sumatra is bawang batak (Allium chinense G.Don.). This study is conducted to assess the antimicrobial activity of bawang batak bulbs in several concentrations to MRSA. Methods: This research is an experimental research with agar diffusion method. The extracts were divided into six groups: extracts in concentration level of 6.25%, 12.5%, 25%, 50%, 100% and a negative control (DMSO). The sample size is four per group with total sample of 24. Results: The results showed that the inhibition of bacterial growth occured at the concentration levels of 50% and 100% with inhibition zone diameters of 8.695 mm and 10.545 mm respectively. Extracts with concentration levels of 25%, 12.5% and 6.25% did not show any inhibition. Conclusion: Bawang batak bulbs extract can be used to inhibit the growth of MRSA","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133235187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Apoptotic Index Fails to Predict Chemoresponse in Breast Cancer 凋亡指数不能预测乳腺癌的化疗反应
Pub Date : 2019-06-01 DOI: 10.32734/SUMEJ.V2I2.1062
K. Siregar
The responsiveness of neoadjuvant chemotherapy in Triple Negative Breast Cancer (TNBC) needs determination to prevent overtreatment with chemoresistance regimen. A total of 60 consented patients from Haji Adam Malik and Bunda Thamrin Hospital were included in this cohort prospectie study. Patients with heart, kidney, liver disease, history of surgery, chemotherapy, or hormonal therapy were excluded. Apoptotic indexes were taken from all subjects before and after neoadjuvant chemotherapy. After 3 cycles of neoadjuvant chemotherapy, 31 subjects (51.7%) did not show clinical response while 29 subjects (48.3%) had clinical response. There was no significant difference of apoptotic index before and after neoadjuvant chemotherapy (5.47+1.38 vs 5.52+1.08 pg/mL). There was also no significant relationship between apoptosis index and clinical response (p=0.993). This study showed that apoptotic index fails to be neoadjuvant chemotherapy response predictor in triple negative breast cancer. Further research with larger samples is needed to confirm this result
三阴性乳腺癌(TNBC)新辅助化疗的反应性需要确定,以防止化疗耐药方案过度治疗。来自Haji Adam Malik和Bunda Thamrin医院的60名患者被纳入这项队列前瞻性研究。排除有心脏、肾脏、肝脏疾病、手术史、化疗史或激素治疗史的患者。在新辅助化疗前后测定所有受试者的细胞凋亡指标。新辅助化疗3个周期后,31例(51.7%)患者无临床反应,29例(48.3%)患者有临床反应。新辅助化疗前后细胞凋亡指数差异无统计学意义(5.47+1.38 vs 5.52+1.08 pg/mL)。细胞凋亡指数与临床疗效无显著相关性(p=0.993)。本研究表明,凋亡指数不能作为三阴性乳腺癌新辅助化疗反应的预测指标。进一步的研究需要更大的样本来证实这一结果
{"title":"Apoptotic Index Fails to Predict Chemoresponse in Breast Cancer","authors":"K. Siregar","doi":"10.32734/SUMEJ.V2I2.1062","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I2.1062","url":null,"abstract":"The responsiveness of neoadjuvant chemotherapy in Triple Negative Breast Cancer (TNBC) needs determination to prevent overtreatment with chemoresistance regimen. A total of 60 consented patients from Haji Adam Malik and Bunda Thamrin Hospital were included in this cohort prospectie study. Patients with heart, kidney, liver disease, history of surgery, chemotherapy, or hormonal therapy were excluded. Apoptotic indexes were taken from all subjects before and after neoadjuvant chemotherapy. After 3 cycles of neoadjuvant chemotherapy, 31 subjects (51.7%) did not show clinical response while 29 subjects (48.3%) had clinical response. There was no significant difference of apoptotic index before and after neoadjuvant chemotherapy (5.47+1.38 vs 5.52+1.08 pg/mL). There was also no significant relationship between apoptosis index and clinical response (p=0.993). This study showed that apoptotic index fails to be neoadjuvant chemotherapy response predictor in triple negative breast cancer. Further research with larger samples is needed to confirm this result","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127149594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes In Glutamic Oxaloacetic Transaminase Serum (SGOT) and Glutamic Pyruvic Transaminase Serum (SGPT) Value In Laparoscopic Cholecystectomy Patient at USU Hospital USU医院腹腔镜胆囊切除术患者血清谷草转氨酶(SGOT)和谷丙转氨酶(SGPT)的变化
Pub Date : 2019-04-20 DOI: 10.32734/SUMEJ.V3I2.3273
Aziizah Gita, Adi Muradi Muhar
Background. Laparoscopic cholecystectomy has become more widely used choice compared to laparotomy cholecystectomy. Laparoscopic cholecystectomy has now become the gold standard of abdominal surgery for abdominal surgery for gallbladder abnormalities, more than 90% of patients with gallstone disease are treated surgically by laparoscopy, but several studies have revealed an increase in SGOT &SGPT values in these surgical procedures. SGPT itself occurs due to the procedure of laparoscopy. In the procedure, there is a temporary increase in the pneumoperitoneum, the pressure on the pneumoperitoneum and its duration affect the severity of ischemia by causing an increase in this liver enzyme. Among several studies, one of them revealed that at 48 hours after laparoscopic cholecystectomy surgery an enzyme increase. Objective. The purpose of the study, this research was conducted to see the changes in SGOT & SGPT values in laparoscopic cholecystectomy surgery. Method. This research method is analytic with cross sectional study design conducted at North Sumatera University Hospital. This research was conducted by looking at secondary data, namely the medical record of patients with gallstones who underwent laparoscopic cholecystectomy surgery from January 2019 to November 2019. The sample was selected by using total sampling method. Data were then analyzed using statistical application software. The number of samples was 45 samples with a diagnosis of gallstones who performed laparoscopic cholecystectomy. Results. Wilcoxon test results showed a significant change between SGOT and SGPT levels before performing operations with SGOT and SGPT levels after surgery with p=0.000 (p<0,05). Conclusion. There are changes in SGOT & SGPT in laparoscopic cholecystectomy.
背景。与开腹胆囊切除术相比,腹腔镜胆囊切除术已成为更广泛应用的选择。腹腔镜胆囊切除术现已成为腹部手术治疗胆囊异常的金标准,90%以上的胆结石患者采用腹腔镜手术治疗,但多项研究表明,在这些手术过程中,SGOT和sgpt值有所增加。SGPT本身是由腹腔镜手术引起的。在手术过程中,气腹暂时增加,气腹上的压力及其持续时间通过引起这种肝酶的增加来影响缺血的严重程度。在几项研究中,其中一项研究显示,在腹腔镜胆囊切除术后48小时,酶增加。目标。本研究的目的是观察腹腔镜胆囊切除术中SGOT和SGPT值的变化。方法。本研究方法采用横断面研究设计,在北苏门答腊大学医院进行分析。本研究是通过查看次级数据,即2019年1月至2019年11月接受腹腔镜胆囊切除术的胆结石患者的病历进行的。采用全抽样法选取样本。然后用统计应用软件对数据进行分析。样本数量为45例诊断为胆结石并行腹腔镜胆囊切除术的样本。结果。Wilcoxon检验结果显示,术前SGOT、SGPT水平与术后SGOT、SGPT水平差异有统计学意义,p=0.000 (p< 0.05)。结论。腹腔镜胆囊切除术中SGOT和SGPT的变化。
{"title":"Changes In Glutamic Oxaloacetic Transaminase Serum (SGOT) and Glutamic Pyruvic Transaminase Serum (SGPT) Value In Laparoscopic Cholecystectomy Patient at USU Hospital","authors":"Aziizah Gita, Adi Muradi Muhar","doi":"10.32734/SUMEJ.V3I2.3273","DOIUrl":"https://doi.org/10.32734/SUMEJ.V3I2.3273","url":null,"abstract":"Background. Laparoscopic cholecystectomy has become more widely used choice compared to laparotomy cholecystectomy. Laparoscopic cholecystectomy has now become the gold standard of abdominal surgery for abdominal surgery for gallbladder abnormalities, more than 90% of patients with gallstone disease are treated surgically by laparoscopy, but several studies have revealed an increase in SGOT &SGPT values in these surgical procedures. SGPT itself occurs due to the procedure of laparoscopy. In the procedure, there is a temporary increase in the pneumoperitoneum, the pressure on the pneumoperitoneum and its duration affect the severity of ischemia by causing an increase in this liver enzyme. Among several studies, one of them revealed that at 48 hours after laparoscopic cholecystectomy surgery an enzyme increase. Objective. The purpose of the study, this research was conducted to see the changes in SGOT & SGPT values in laparoscopic cholecystectomy surgery. Method. This research method is analytic with cross sectional study design conducted at North Sumatera University Hospital. This research was conducted by looking at secondary data, namely the medical record of patients with gallstones who underwent laparoscopic cholecystectomy surgery from January 2019 to November 2019. The sample was selected by using total sampling method. Data were then analyzed using statistical application software. The number of samples was 45 samples with a diagnosis of gallstones who performed laparoscopic cholecystectomy. Results. Wilcoxon test results showed a significant change between SGOT and SGPT levels before performing operations with SGOT and SGPT levels after surgery with p=0.000 (p<0,05). Conclusion. There are changes in SGOT & SGPT in laparoscopic cholecystectomy.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"196 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120983652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Factors Affecting Gastrointestinal Disorders in Patients Undergoing Regular Hemodialysis 定期血液透析患者胃肠道疾病的影响因素
Pub Date : 2019-04-20 DOI: 10.32734/SUMEJ.V3I2.3000
rosarina pasaribu, R. Muzasti
Background: Chronic Kidney Disease (CKD) is an immense health issue. The prevalence is increasing each year worldwide, including Indonesia. Consistent with this trend, the prevalence of hemodialysis (HD) as a therapy is also increasing. CKD as well as HD often result in some complications, one being gastrointestinal disorders. Many factors are  correlated  with the incidence of gastrointestinal disorders in CKD patients undergoing HD. Objective: This research is held to observe the factors affecting gastrointestinal disorders in regular HD patients. Method: This is an observational analytical research with cross-sectional study at RS Khusus Ginjal Rasyida Medan. The datas used in the research are primary datas, obtained from Gastrointestinal Symptoms Rating Scale (GSRS) questionnaire to assess severity of gastrointestnal disorders in HD patients, and secondary datas, obtained from medical records of age, smoking history, use of aspirin, HD duration, BUN, and Kt/V (as a parameter of HD adequacy). Then the datas are analyzed univariately, bivariately, and mutivariately using biner logistic regression model. It is considered significant if the obtained p value is <0,05 (p<0,05). Result: All patients (100%) suffer from gastrointestinal disorders, with the most common being mild ones (67,1%). Final multivariate analysis shows that the duration of HD, BUN level, and Kt/V are significantly  correlated  with worsening gastrointestinal disorders (OR:14,157 ,95%CI 2,851 ± 71,183, p=0,001; OR: 8,352, 95%CI 0,914 ± 76,344, p= 0,060; OR:8,219 ,95%CI 0,893 ± 75,674, p= 0,063). Conclusion: The duration of HD, BUN level, and Kt/V are  correlated  with worsening gastrointestinal disorders in HD patients.
背景:慢性肾脏疾病(CKD)是一个巨大的健康问题。包括印度尼西亚在内的世界范围内,流行率每年都在上升。与这一趋势一致,血液透析(HD)作为一种治疗方法的患病率也在增加。CKD和HD经常导致一些并发症,其中之一是胃肠道疾病。许多因素与CKD合并HD患者胃肠道疾病的发生率相关。目的:观察普通HD患者胃肠道疾病的影响因素。方法:采用横断面研究的方法,对棉兰胡胡斯银杏树进行观察分析。本研究使用的数据主要来自胃肠道症状评定量表(GSRS)问卷,用于评估HD患者胃肠道疾病的严重程度;次要数据来自年龄、吸烟史、阿司匹林使用情况、HD持续时间、BUN和Kt/V(作为HD充分性的参数)等医疗记录。然后利用线性回归模型对数据进行单变量、双变量和多变量分析。如果得到的p值< 0.05 (p< 0.05),则认为具有显著性。结果:所有患者(100%)均出现胃肠功能紊乱,以轻度为主(67.1%)。最终的多因素分析显示,HD持续时间、BUN水平和Kt/V与胃肠道疾病恶化显著相关(OR:14,157,95%CI 2,851±71,183,p=0,001;OR: 8,352, 95%CI: 0,914±76,344,p= 0,060;OR:8,219,95%CI = 0,893±75,674,p= 0,063)。结论:HD病程、BUN水平、Kt/V与HD患者胃肠道疾病恶化相关。
{"title":"Factors Affecting Gastrointestinal Disorders in Patients Undergoing Regular Hemodialysis","authors":"rosarina pasaribu, R. Muzasti","doi":"10.32734/SUMEJ.V3I2.3000","DOIUrl":"https://doi.org/10.32734/SUMEJ.V3I2.3000","url":null,"abstract":"Background: Chronic Kidney Disease (CKD) is an immense health issue. The prevalence is increasing each year worldwide, including Indonesia. Consistent with this trend, the prevalence of hemodialysis (HD) as a therapy is also increasing. CKD as well as HD often result in some complications, one being gastrointestinal disorders. Many factors are  correlated  with the incidence of gastrointestinal disorders in CKD patients undergoing HD. Objective: This research is held to observe the factors affecting gastrointestinal disorders in regular HD patients. Method: This is an observational analytical research with cross-sectional study at RS Khusus Ginjal Rasyida Medan. The datas used in the research are primary datas, obtained from Gastrointestinal Symptoms Rating Scale (GSRS) questionnaire to assess severity of gastrointestnal disorders in HD patients, and secondary datas, obtained from medical records of age, smoking history, use of aspirin, HD duration, BUN, and Kt/V (as a parameter of HD adequacy). Then the datas are analyzed univariately, bivariately, and mutivariately using biner logistic regression model. It is considered significant if the obtained p value is <0,05 (p<0,05). Result: All patients (100%) suffer from gastrointestinal disorders, with the most common being mild ones (67,1%). Final multivariate analysis shows that the duration of HD, BUN level, and Kt/V are significantly  correlated  with worsening gastrointestinal disorders (OR:14,157 ,95%CI 2,851 ± 71,183, p=0,001; OR: 8,352, 95%CI 0,914 ± 76,344, p= 0,060; OR:8,219 ,95%CI 0,893 ± 75,674, p= 0,063). Conclusion: The duration of HD, BUN level, and Kt/V are  correlated  with worsening gastrointestinal disorders in HD patients.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124957245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Cancer Patient Characeristics By Menarche In Adam Malik Hospital 2014-2017 2014-2017年亚当马利克医院乳腺癌患者月经初潮特征分析
Pub Date : 2019-04-20 DOI: 10.32734/SUMEJ.V3I2.3277
cynthia ervina, Dedy Hermansyah
Background. Breast cancer is one of the most diagnosed cancer in the world. Breast cancer starts when the breast cell grows abnormally and turns malignant. In Indonesia, breast cancer is the most diagnosed cancer in women. Up to now, the cause of breast cancer has not been identified yet. There are many factors that increase the risk of breast cancer, one of them is the early age of menarche. Objective. This study aims to obtain characteristics of breast cancer patients based on age of menarche in RSUP Haji Adam Malik in 2014-2017. Method. The study was designed in observational with descriptive method. The sampling had been done using total sampling technique. Results. Based on general characteristics, the majority of breast cancer patients are in the range of 40-49 years old (38,5%), graduated high school (45,2%), unemployed (66,3%), and do not have family history (94,2%). Majority of patients have stadium IIIB breast cancer (41,3%). The most diagnosed histopathology is Invasive Ductal Carcinoma (78,8%). Majority of breast cancer patients have negative estrogen receptor (67,3%), negative progesterone receptor (67,3%), negative her2 (66,3%) and positive ki-67 (67,3%). Fifty three breast cancer patients (51%) have early menarche. Based on the age of menarche, the patient with early menarche mostly has stage three breast cancer, but the age of menarche does not give a specific characteristic in histopathology and immunohistochemistry. Conclusion. Age of menarche gives specific characteristic in staging but not in histopathology and immunohistochemistry.
背景。乳腺癌是世界上诊断最多的癌症之一。当乳腺细胞异常生长并变成恶性肿瘤时,乳腺癌就开始了。在印度尼西亚,乳腺癌是女性中诊断最多的癌症。到目前为止,乳腺癌的病因还没有被确定。有很多因素会增加患乳腺癌的风险,其中之一就是月经初潮的年龄过早。目标。本研究旨在获取RSUP Haji Adam Malik 2014-2017年乳腺癌患者月经初潮年龄的特征。方法。本研究采用描述性观察法设计。采用全采样技术进行采样。结果。从总体特征来看,大多数乳腺癌患者年龄在40-49岁(38.5%),高中毕业(45.2%),无业(66.3%),无家族史(94.2%)。大多数患者为体育场IIIB乳腺癌(41.3%)。组织病理学诊断最多的是浸润性导管癌(78.8%)。大多数乳腺癌患者雌激素受体阴性(67.3%)、孕激素受体阴性(67.3%)、her2阴性(66.3%)、ki-67阳性(67.3%)。53例乳腺癌患者(51%)月经初潮早。从初潮的年龄来看,初潮早的患者多为三期乳腺癌,但初潮的年龄在组织病理学和免疫组织化学上并没有给出具体的特征。结论。初潮年龄在分期上具有特异性,但在组织病理学和免疫组织化学上没有特异性。
{"title":"Breast Cancer Patient Characeristics By Menarche In Adam Malik Hospital 2014-2017","authors":"cynthia ervina, Dedy Hermansyah","doi":"10.32734/SUMEJ.V3I2.3277","DOIUrl":"https://doi.org/10.32734/SUMEJ.V3I2.3277","url":null,"abstract":"Background. Breast cancer is one of the most diagnosed cancer in the world. Breast cancer starts when the breast cell grows abnormally and turns malignant. In Indonesia, breast cancer is the most diagnosed cancer in women. Up to now, the cause of breast cancer has not been identified yet. There are many factors that increase the risk of breast cancer, one of them is the early age of menarche. Objective. This study aims to obtain characteristics of breast cancer patients based on age of menarche in RSUP Haji Adam Malik in 2014-2017. Method. The study was designed in observational with descriptive method. The sampling had been done using total sampling technique. Results. Based on general characteristics, the majority of breast cancer patients are in the range of 40-49 years old (38,5%), graduated high school (45,2%), unemployed (66,3%), and do not have family history (94,2%). Majority of patients have stadium IIIB breast cancer (41,3%). The most diagnosed histopathology is Invasive Ductal Carcinoma (78,8%). Majority of breast cancer patients have negative estrogen receptor (67,3%), negative progesterone receptor (67,3%), negative her2 (66,3%) and positive ki-67 (67,3%). Fifty three breast cancer patients (51%) have early menarche. Based on the age of menarche, the patient with early menarche mostly has stage three breast cancer, but the age of menarche does not give a specific characteristic in histopathology and immunohistochemistry. Conclusion. Age of menarche gives specific characteristic in staging but not in histopathology and immunohistochemistry.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"1967 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130132565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timi Flow Between Streptokinase and Alteplase in Successful Fibrinolytic 纤溶成功的链激酶和阿替普酶之间的Timi流动
Pub Date : 2019-01-30 DOI: 10.32734/SUMEJ.V2I1.716
Dika Ashrinda, R. Hasan, Cut A. Andra, Zulfikri Muhtar, H. Hasan
STEMI with onset≤12 hours, necessary to take Primary Percutaneous Coronary Intervention (pPCI), but if there is no facility, another therapy is fibrinolytic, to improve blood flow in the coronary artery and myocardial function, thus reducing infarction expansion. This is a retrospective study in STEMI patients onset≤12 hours, had performed successful fibrinolytic with Streptokinase (SK) and Alteplase (tPA) from January 2015 to August 2017. TIMI flow was assessed by coronary angiography. There were 54 patients who had performed successful fibrinolytic therapy with SK and tPA; each group had 27 patients. In the SK group, there were nine patients (33.3%) with TIMI flow 2 and 18 patients (66.7%) with TIMI flow 3. While in the tPA group there were 11 patients (40.7%) with TIMI flow 2, 16 patients (59.3%) with TIMI flow 3, (p=0.573). There is no difference in TIMI flow between SK and tPA on STEMI patients after success fibrinolytic therapy.
STEMI起病≤12小时,需行原发性经皮冠状动脉介入治疗(pPCI),但如无设备,另一种治疗是纤溶治疗,以改善冠状动脉血流量和心肌功能,从而减少梗死扩大。这是一项回顾性研究,在2015年1月至2017年8月期间,STEMI患者发病≤12小时,已成功使用链激酶(SK)和阿替普酶(tPA)进行纤溶。冠状动脉造影评估TIMI流量。54例患者成功地接受了SK和tPA的纤溶治疗;每组27例。SK组TIMI流量2为9例(33.3%),TIMI流量3为18例(66.7%)。tPA组TIMI流量2为11例(40.7%),TIMI流量3为16例(59.3%),差异有统计学意义(p=0.573)。在STEMI患者纤溶治疗成功后,SK和tPA之间的TIMI流量没有差异。
{"title":"Timi Flow Between Streptokinase and Alteplase in Successful Fibrinolytic","authors":"Dika Ashrinda, R. Hasan, Cut A. Andra, Zulfikri Muhtar, H. Hasan","doi":"10.32734/SUMEJ.V2I1.716","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I1.716","url":null,"abstract":"STEMI with onset≤12 hours, necessary to take Primary Percutaneous Coronary Intervention (pPCI), but if there is no facility, another therapy is fibrinolytic, to improve blood flow in the coronary artery and myocardial function, thus reducing infarction expansion. \u0000This is a retrospective study in STEMI patients onset≤12 hours, had performed successful fibrinolytic with Streptokinase (SK) and Alteplase (tPA) from January 2015 to August 2017. TIMI flow was assessed by coronary angiography. There were 54 patients who had performed successful fibrinolytic therapy with SK and tPA; each group had 27 patients. In the SK group, there were nine patients (33.3%) with TIMI flow 2 and 18 patients (66.7%) with TIMI flow 3. While in the tPA group there were 11 patients (40.7%) with TIMI flow 2, 16 patients (59.3%) with TIMI flow 3, (p=0.573). There is no difference in TIMI flow between SK and tPA on STEMI patients after success fibrinolytic therapy.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122830213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Comparison of Er α Expression Between Endometriosis with No Endometriosis 子宫内膜异位症与无子宫内膜异位症Er α表达的比较
Pub Date : 2019-01-30 DOI: 10.32734/SUMEJ.V2I1.714
D. Irsat Syafardi, H. Siregar, Y. B. Kaban, E. Ardiansyah
Estrogen receptors (ER) play an important role in mediating action. The ER α has a higher affinity for estrogen and the dominant form of the normal endometrium. A cross-sectional study from an ectopic  tissue of endo-metriosis and normal was examined for immunohistochemistry. This research was conducted from November 2015 until the sample complete. The analysis was performed using Fisher Exact test, p <0.05 was considered to any difference of estrogen alpha receptor expression between endometriosis patients with no endometriosis. REα is more dominant in normal endometrium, whereas in the case of endometriosis in the presence of many negative expression of REα then the assumption that REβ is a receptor that many encountered. There is a dif-ference in the expression of REα between endometriosis with no endometriosis.
雌激素受体(ER)在其中起着重要的调节作用。ER α对雌激素和正常子宫内膜的优势形态有较高的亲和力。横断面研究从异位组织子宫内膜异位症和正常检查免疫组织化学。本研究从2015年11月开始,直至样本完成。采用Fisher精确检验进行分析,雌激素受体在子宫内膜异位症患者与非子宫内膜异位症患者之间的表达差异以p <0.05考虑。REα在正常子宫内膜中更占优势,而在子宫内膜异位症的情况下,存在许多REα的负表达,那么假设REβ是许多遇到的受体。REα在子宫内膜异位症与非子宫内膜异位症的表达有差异。
{"title":"The Comparison of Er α Expression Between Endometriosis with No Endometriosis","authors":"D. Irsat Syafardi, H. Siregar, Y. B. Kaban, E. Ardiansyah","doi":"10.32734/SUMEJ.V2I1.714","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I1.714","url":null,"abstract":"Estrogen receptors (ER) play an important role in mediating action. The ER α has a higher affinity for estrogen and the dominant form of the normal endometrium. A cross-sectional study from an ectopic  tissue of endo-metriosis and normal was examined for immunohistochemistry. This research was conducted from November 2015 until the sample complete. The analysis was performed using Fisher Exact test, p <0.05 was considered to any difference of estrogen alpha receptor expression between endometriosis patients with no endometriosis. REα is more dominant in normal endometrium, whereas in the case of endometriosis in the presence of many negative expression of REα then the assumption that REβ is a receptor that many encountered. There is a dif-ference in the expression of REα between endometriosis with no endometriosis.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116122416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies IHC中MMP7和VEGF表达与卵巢正常及卵巢病变的关系
Pub Date : 2019-01-30 DOI: 10.32734/SUMEJ.V2I1.719
M. Rusda, R. Rivany, C. L. Hasibuan, D. Lutan, D. Aldiansyah, C. A. Adella
To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence.
探讨MMP7和VEGF表达与卵巢癌、良性卵巢囊肿和正常卵巢的关系。本研究为分析性研究,采用病例对照设计。本研究在卵巢癌组织、良性卵巢囊肿和正常卵巢石蜡块上进行了MMP7和VEGF的免疫组化表达。在40例卵巢肿瘤患者中,17例发现MMP7阳性表达。对照组未见MMP7阳性表达。MMP7表达与卵巢肿瘤发生率有显著相关性。同时,在40例卵巢肿瘤患者中,有21例VEGF阳性表达。对照组未见VEGF阳性表达。VEGF表达与卵巢肿瘤发生率有显著相关性。MMP7、VEGF表达与卵巢肿瘤发生率有显著相关性。
{"title":"IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies","authors":"M. Rusda, R. Rivany, C. L. Hasibuan, D. Lutan, D. Aldiansyah, C. A. Adella","doi":"10.32734/SUMEJ.V2I1.719","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I1.719","url":null,"abstract":"To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123682220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Vitamin A in Albendazole Against Reinfection of Ascaris Lumbricoides 阿苯达唑中的维生素 A 对蛔虫再感染的有效性
Pub Date : 2019-01-30 DOI: 10.32734/SUMEJ.V2I1.718
Richo Wijaya, M. Lubis, Selfi Nafianti, I. Lubis
WHO recommends the supplementation of 200,000 IU vitamin A into 400 mg albendazole to cut down its reinfection. A Randomized Controlled Trial was conducted in SD N 384  Sikapas, North Sumatera from April - June 2016. Inclusion criteria were children with ascariasis. Sample divided into intervention and control group. Kato-Katz was used to identify egg worms and faecal egg count intensity (FECs). P value < 0.05 was consider significant. After three months follow up, there were 51 and 56 samples in intervention and control group with average age 9.6 years (SD 1.99) and 9.7 years (SD 2.20). Prevalence of ascariasis was 75.5%. There was no significant difference in Ascaris lumbricoides reinfection but instead of in FECs intensity. The NNT was 22.31. The addition of vitamin A in albendazole was not suggested according to this study.
世卫组织建议在 400 毫克阿苯达唑中加入 20 万国际单位的维生素 A,以减少再次感染。2016年4月至6月,一项随机对照试验在北苏门答腊省SD N 384 Sikapas进行。纳入标准为患有蛔虫病的儿童。样本分为干预组和对照组。采用卡托-卡茨法识别虫卵和粪便虫卵计数强度(FECs)。P值小于0.05为差异显著。经过三个月的随访,干预组和对照组分别有 51 和 56 个样本,平均年龄分别为 9.6 岁(SD 1.99)和 9.7 岁(SD 2.20)。蛔虫病发病率为 75.5%。干预组和对照组在蛔虫再感染方面没有明显差异,但在蛔虫感染强度方面有明显差异。NNT 为 22.31。本研究不建议在阿苯达唑中添加维生素 A。
{"title":"Effectiveness of Vitamin A in Albendazole Against Reinfection of Ascaris Lumbricoides","authors":"Richo Wijaya, M. Lubis, Selfi Nafianti, I. Lubis","doi":"10.32734/SUMEJ.V2I1.718","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I1.718","url":null,"abstract":"WHO recommends the supplementation of 200,000 IU vitamin A into 400 mg albendazole to cut down its reinfection. A Randomized Controlled Trial was conducted in SD N 384  Sikapas, North Sumatera from April - June 2016. Inclusion criteria were children with ascariasis. Sample divided into intervention and control group. Kato-Katz was used to identify egg worms and faecal egg count intensity (FECs). P value < 0.05 was consider significant. After three months follow up, there were 51 and 56 samples in intervention and control group with average age 9.6 years (SD 1.99) and 9.7 years (SD 2.20). Prevalence of ascariasis was 75.5%. There was no significant difference in Ascaris lumbricoides reinfection but instead of in FECs intensity. The NNT was 22.31. The addition of vitamin A in albendazole was not suggested according to this study.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127788409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Torbangun Leaves Tea on Msg-induced Fetal Develop-ment Disorder in Mice 托尔班冈叶茶对小鼠肌电诱导的胎儿发育障碍的影响
Pub Date : 2019-01-30 DOI: 10.32734/SUMEJ.V2I1.717
Sufitni M.Kes, L. Feriyawati, Y. Pane, A. Lelo
The safety of MSG on the fetus has not been confirmed yet. The objective of this research is to determine the effect of tea of torbangun leaves on fetal development disorder of mice. The present study is experimental with a Completely Randomized Design (CRD). Data obtained were then analyzed by ANOVA, with p<0,05 as the level of significant.   The comparison of mean values ± SEM increase number of live fetuses  group C1-T1 (4,60 ± 0,93; 11,40 ± 0,87), p=0,018. The comparison of mean values ± SEM decrease number of embryo re-sorption percentage group C0-C1 (00,00 ± 00,00; 36,74 ± 15,13), group C1-C2 (36,74 ± 15,13; 00,00 ± 0,00), group C1-T1 (36,74 ± 15,13; 00,00 ± 0,00), and group C1-T2 (36,74 ± 15,13; 15,00 ± 22,36), p=0,020. This study concluded that T1 group is giving the best effect on increasing life fetuses and decreasing embryo re-sorption percentage.
味精对胎儿的安全性尚未得到证实。本研究的目的是确定大戟叶茶对小鼠胎儿发育障碍的影响。本研究采用完全随机设计(CRD)进行实验。所得数据进行方差分析,以p< 0.05为显著水平。C1-T1组活胎数平均值±SEM增加数比较(4.60±0.93);11.40±0.87),p= 0.018。对照平均值±SEM减少胚胎重吸百分数C0-C1组(00、00±00、00;36,74±15,13),C1-C2组(36,74±15,13;00,00±0,00),C1-T1组(36,74±15,13;00,00±0,00),C1-T2组(36,74±15,13;15,00±22,36),p=0,020。综上所述,T1组在提高胎龄和降低胚胎重吸收率方面效果最好。
{"title":"The Effect of Torbangun Leaves Tea on Msg-induced Fetal Develop-ment Disorder in Mice","authors":"Sufitni M.Kes, L. Feriyawati, Y. Pane, A. Lelo","doi":"10.32734/SUMEJ.V2I1.717","DOIUrl":"https://doi.org/10.32734/SUMEJ.V2I1.717","url":null,"abstract":"The safety of MSG on the fetus has not been confirmed yet. The objective of this research is to determine the effect of tea of torbangun leaves on fetal development disorder of mice. The present study is experimental with a Completely Randomized Design (CRD). Data obtained were then analyzed by ANOVA, with p<0,05 as the level of significant.   The comparison of mean values ± SEM increase number of live fetuses  group C1-T1 (4,60 ± 0,93; 11,40 ± 0,87), p=0,018. The comparison of mean values ± SEM decrease number of embryo re-sorption percentage group C0-C1 (00,00 ± 00,00; 36,74 ± 15,13), group C1-C2 (36,74 ± 15,13; 00,00 ± 0,00), group C1-T1 (36,74 ± 15,13; 00,00 ± 0,00), and group C1-T2 (36,74 ± 15,13; 15,00 ± 22,36), p=0,020. This study concluded that T1 group is giving the best effect on increasing life fetuses and decreasing embryo re-sorption percentage.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134530885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Sumatera Medical Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1