Background. Using personal protective equipment, including masks, is one of the most important ways to prevent coronavirus disease 2019 (COVID-19). The aim of this study was to estimate the prevalence and pattern of mask use and its association with COVID-19-related morbidity and mortality in different areas of Tabriz, Iran. Methods. In this population-based study, 6,600 pedestrians were selected by multi-stage proportional sampling method in nine areas of Tabriz in 2021. The data was collected using the observation method. For each participant, we recorded gender, approximate age, mask usage, type of mask, and correct or incorrect use. The data of COVID-19-related morbidity and mortality for six months (from 21 March 2021 to 22 September 2021) were obtained from the Integrated Syndromic Surveillance System (ISSS). Results. The overall prevalence of facial mask use was 56.8% (95% CI: 55.56 – 57.95). Out of 3,421 men, 1,599 (46.7%; 95% CI: 45.1-48.4) and out of 3,179 women, 2,147 (67.5%; 95% CI: 65.9-69.2) were used face mask (P<0.001). The correlations between mask use and morbidity (r=0.375, P=0.320) and mortality (r=0.219, P=0.571) rates were not statistically significant. Conclusion. The percentage of using face masks in Tabriz was relatively low, especially among males and young people. Also, there was no significant relationship between COVID-19 morbidity and mortality and mask use. Practical Implications. The results of the present study showed that the percentage of mask use in men and the youth was relatively low. In times of disease epidemics, it is necessary to create the necessary sensitivity in these groups and to carry out the necessary training and interventions to increase the use of masks and protective measures.
{"title":"The prevalence and pattern of mask use and its association with COVID-19-related morbidity and mortality in Tabriz, Iran","authors":"Neda Daraee, Parvin Sarbakhsh, Hossein Akbari, Abbasali Dorosti, Mohammadpoorasl Asghar","doi":"10.34172/mj.2023.046","DOIUrl":"https://doi.org/10.34172/mj.2023.046","url":null,"abstract":"Background. Using personal protective equipment, including masks, is one of the most important ways to prevent coronavirus disease 2019 (COVID-19). The aim of this study was to estimate the prevalence and pattern of mask use and its association with COVID-19-related morbidity and mortality in different areas of Tabriz, Iran. Methods. In this population-based study, 6,600 pedestrians were selected by multi-stage proportional sampling method in nine areas of Tabriz in 2021. The data was collected using the observation method. For each participant, we recorded gender, approximate age, mask usage, type of mask, and correct or incorrect use. The data of COVID-19-related morbidity and mortality for six months (from 21 March 2021 to 22 September 2021) were obtained from the Integrated Syndromic Surveillance System (ISSS). Results. The overall prevalence of facial mask use was 56.8% (95% CI: 55.56 – 57.95). Out of 3,421 men, 1,599 (46.7%; 95% CI: 45.1-48.4) and out of 3,179 women, 2,147 (67.5%; 95% CI: 65.9-69.2) were used face mask (P<0.001). The correlations between mask use and morbidity (r=0.375, P=0.320) and mortality (r=0.219, P=0.571) rates were not statistically significant. Conclusion. The percentage of using face masks in Tabriz was relatively low, especially among males and young people. Also, there was no significant relationship between COVID-19 morbidity and mortality and mask use. Practical Implications. The results of the present study showed that the percentage of mask use in men and the youth was relatively low. In times of disease epidemics, it is necessary to create the necessary sensitivity in these groups and to carry out the necessary training and interventions to increase the use of masks and protective measures.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"240 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AmirAli Jafarnezhadgero, Milad Piran Hamlabadi, Masoumeh Nader pour
Background. Different shoe weights affect walking mechanics. Therefore, the purpose of this study was to determine the effect of sport shoe weight on lower extremity muscle activities in athletes with anterior cruciate ligament reconstruction during walking. It was hypothesized that reduced shoe weight results in decreased frequency content of selected muscles during walking. Methods. Twenty healthy males and athletes with ACL reconstruction volunteered and gave their written informed consent to participate in this study. Participants were male and physically active. Each participant performed three walking trials in each of the light (mass per shoe: 150 ± 18 g), medium (300 ± 18 g), and heavy (450 ± 18 g) conditions in a randomized order and electromyography were analyzed during shod walking. Results. EMG results showed that the increase in shoe weight was directly related to the increase in electrical activity of the muscles, but only in the swing phase was the electrical activity of the TA muscle decreased. Conclusion. Different shoe weights affect the electrical activity of the muscles and the walking speed. Therefore, lighter weight shoes are recommended for patients with ACL. Practical Implications. The results of this study show that light shoes are useful for patients with anterior cruciate ligament rupture and the use of lightweight shoes is recommended for people with anterior cruciate ligament rupture.
{"title":"Effect of sports shoe weight on lower limb muscle activities in athletes with ACL reconstruction during walking","authors":"AmirAli Jafarnezhadgero, Milad Piran Hamlabadi, Masoumeh Nader pour","doi":"10.34172/mj.2023.047","DOIUrl":"https://doi.org/10.34172/mj.2023.047","url":null,"abstract":"Background. Different shoe weights affect walking mechanics. Therefore, the purpose of this study was to determine the effect of sport shoe weight on lower extremity muscle activities in athletes with anterior cruciate ligament reconstruction during walking. It was hypothesized that reduced shoe weight results in decreased frequency content of selected muscles during walking. Methods. Twenty healthy males and athletes with ACL reconstruction volunteered and gave their written informed consent to participate in this study. Participants were male and physically active. Each participant performed three walking trials in each of the light (mass per shoe: 150 ± 18 g), medium (300 ± 18 g), and heavy (450 ± 18 g) conditions in a randomized order and electromyography were analyzed during shod walking. Results. EMG results showed that the increase in shoe weight was directly related to the increase in electrical activity of the muscles, but only in the swing phase was the electrical activity of the TA muscle decreased. Conclusion. Different shoe weights affect the electrical activity of the muscles and the walking speed. Therefore, lighter weight shoes are recommended for patients with ACL. Practical Implications. The results of this study show that light shoes are useful for patients with anterior cruciate ligament rupture and the use of lightweight shoes is recommended for people with anterior cruciate ligament rupture.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Feeling loneliness is a prevalent phenomenon, affecting 25-50% of the population over 65 years old. The present study aimed to investigate feeling lonely in the elderly in Iran. Methods. This review study was conducted by searching the keywords elderly, loneliness, isolation, elderly, old age, older people, and feeling loneliness. We retrieved all published cross-sectional articles in Persian and English languages from 2006 to 2021. Evaluation of the quality of the studies and data extraction was done by reading the full texts of the selected articles, using the STROBE Checklists for cross-sectional studies. Articles that had the required quality were included in the study. Results. In this research, 128 articles were found in the initial review. A total of 26 articles were included in the study after preliminary reviews. According to the studies, the average score of loneliness in the elderly was high. Also, due to the lack of social relations, the average score of loneliness in the elderly staying in nursing homes and far from their families was higher than the elderly living in the family. Conclusion. The average loneliness score among the elderly, especially those living in nursing homes, was relatively high. Creating the necessary conditions to maintain social relationships among the elderly can reduce their level of loneliness and prevent the adverse consequences of loneliness in them. Practical Implications. Considering the importance of improving the mental health of the elderly, it is recommended to strengthen the counseling of the elderly, reduce treatment costs, and also involve the elderly in daily activities and talk with a group of friends to reduce their loneliness. The results of this research can be used to improve the level of awareness of policymakers, people, and families and increase the mental health of the elderly.
{"title":"Feeling Lonely among the Elderly in Iran: A Systematic Review","authors":"Vali Bahrevar, Yadollah Abolfathi Momtaz, Saeed Hosseini","doi":"10.34172/mj.2023.041","DOIUrl":"https://doi.org/10.34172/mj.2023.041","url":null,"abstract":"Background. Feeling loneliness is a prevalent phenomenon, affecting 25-50% of the population over 65 years old. The present study aimed to investigate feeling lonely in the elderly in Iran. Methods. This review study was conducted by searching the keywords elderly, loneliness, isolation, elderly, old age, older people, and feeling loneliness. We retrieved all published cross-sectional articles in Persian and English languages from 2006 to 2021. Evaluation of the quality of the studies and data extraction was done by reading the full texts of the selected articles, using the STROBE Checklists for cross-sectional studies. Articles that had the required quality were included in the study. Results. In this research, 128 articles were found in the initial review. A total of 26 articles were included in the study after preliminary reviews. According to the studies, the average score of loneliness in the elderly was high. Also, due to the lack of social relations, the average score of loneliness in the elderly staying in nursing homes and far from their families was higher than the elderly living in the family. Conclusion. The average loneliness score among the elderly, especially those living in nursing homes, was relatively high. Creating the necessary conditions to maintain social relationships among the elderly can reduce their level of loneliness and prevent the adverse consequences of loneliness in them. Practical Implications. Considering the importance of improving the mental health of the elderly, it is recommended to strengthen the counseling of the elderly, reduce treatment costs, and also involve the elderly in daily activities and talk with a group of friends to reduce their loneliness. The results of this research can be used to improve the level of awareness of policymakers, people, and families and increase the mental health of the elderly.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saber Ghaderpour, Ali Akbar Shekarchi, Sara Rahbar, Javad Ashrafi helan, Fariba Ghiasi
Background. Resistance exercise is a method designed to increase muscle strength and endurance, leading to beneficial physiological changes in various tissues. The aim of this study is to investigate the pathological and structural effects of short-term and long-term resistance training on various tissues of male rats, including cardiac striatum, quadriceps, liver, kidney, and lung tissue. Methods. Forty male Wistar rats were randomly divided into four groups: one-month control, four-month control, one-month exercise, and four-month exercise. After the exercise period, the animals were anesthetized and dissected to separate various tissues, which were then treated with formalin and prepared for analysis. Results. The study findings showed that liver tissue did not show significant histopathological changes in response to exercise. However, in the heart tissue, mild hyperemia and hypertrophy of muscle cells were observed in the exercise groups compared to the control groups. In the quadriceps muscle, hypertrophy was observed to a lesser extent in the one-month exercise group and to a greater extent in the four-month exercise group. There was a significant difference in the diameter of the muscle cells of the quadriceps muscle between the one-month and four-month exercise groups, indicating the beneficial effects of long-term exercise. Additionally, an increase in the size of the epithelial tissue of the urinary tubes was observed in both exercise groups, which indicates an increase in kidney function due to exercise. Conclusion. Overall, the results of this study show that resistance exercise can lead to beneficial physiological changes in various tissues, especially with long-term exercise. Understanding these changes can increase our knowledge about the benefits of exercise. Practical Implications. Resistance exercises, through actions such as hyperemia, hypertrophy of muscle cells, and hypertrophy of the epithelial tissue of urinary tubes, improve the efficiency of the heart, kidneys and muscles during sports exercises, especially with long-term exercise.
{"title":"Pathological and structural study of cardiac striated muscle and quadriceps along with the study of microscopic changes in liver, kidney and lung tissue following short-term and long-term resistance exercises in male rats","authors":"Saber Ghaderpour, Ali Akbar Shekarchi, Sara Rahbar, Javad Ashrafi helan, Fariba Ghiasi","doi":"10.34172/mj.2023.045","DOIUrl":"https://doi.org/10.34172/mj.2023.045","url":null,"abstract":"Background. Resistance exercise is a method designed to increase muscle strength and endurance, leading to beneficial physiological changes in various tissues. The aim of this study is to investigate the pathological and structural effects of short-term and long-term resistance training on various tissues of male rats, including cardiac striatum, quadriceps, liver, kidney, and lung tissue. Methods. Forty male Wistar rats were randomly divided into four groups: one-month control, four-month control, one-month exercise, and four-month exercise. After the exercise period, the animals were anesthetized and dissected to separate various tissues, which were then treated with formalin and prepared for analysis. Results. The study findings showed that liver tissue did not show significant histopathological changes in response to exercise. However, in the heart tissue, mild hyperemia and hypertrophy of muscle cells were observed in the exercise groups compared to the control groups. In the quadriceps muscle, hypertrophy was observed to a lesser extent in the one-month exercise group and to a greater extent in the four-month exercise group. There was a significant difference in the diameter of the muscle cells of the quadriceps muscle between the one-month and four-month exercise groups, indicating the beneficial effects of long-term exercise. Additionally, an increase in the size of the epithelial tissue of the urinary tubes was observed in both exercise groups, which indicates an increase in kidney function due to exercise. Conclusion. Overall, the results of this study show that resistance exercise can lead to beneficial physiological changes in various tissues, especially with long-term exercise. Understanding these changes can increase our knowledge about the benefits of exercise. Practical Implications. Resistance exercises, through actions such as hyperemia, hypertrophy of muscle cells, and hypertrophy of the epithelial tissue of urinary tubes, improve the efficiency of the heart, kidneys and muscles during sports exercises, especially with long-term exercise.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Cardiotoxicity caused by fluoropyrimidines is an uncommon but potentially fatal complication. Its frequency has been 1.6 to 19% in previous studies. But there are no accurate statistics in Iran. The aim of this study was to determine the rate of cardiac complications of 5-fluorouracil (5-FU) infusion. Methods. This prospective study was conducted in patients with gastrointestinal cancers who underwent chemotherapy with regimens containing 24-hour infusion of 5-FU at Rohani Hospital of Babol. Patients with a history of radiation therapy to the chest or epigastrium or suffering from COVID-19 disease in the last 6 weeks were excluded from the study. Each patient was examined in 2 cycles of chemotherapy. In case of complications, cardiac examinations including examination, electrocardiogram, echocardiography and if necessary, coronary angiography were done. Data analysis was done with SPSS 26 software using descriptive indices and Fisher exact test (significance≤0.05). Results. In sixty one patients, 122 courses of chemotherapy were evaluated. Underlying cancer was colorectal cancer in 32 patients, stomach cancer in people. Eight patients (13.11%) had cardiac complication, in eleven chemotherapy cycles, included 7 cases of chest pain and one case of each of complications of myocardial infarction, pulmonary edema and pericarditis. Four out of 8 patients suffered from complications only in the first round, one only in the second round and three patients in both rounds of chemotherapy (P=0.004).The incidence rate of complications in patients without a history of heart disease was 8.7% and in patients with a history of heart disease 26.7%(P=0.073), in non-smokers 10% and in smokers 30%(P=0.084). It was 10.6% in non-diabetic patients and 21.4% in diabetic patients (P=0.294). Conclusion. Cardiac complications are common in 24-hour injection of 5-fluorouracil. A patient who has a heart complication once, might have a higher probability of having a complication in the next cycles. Practical Implications. Due to the high prevalence of cardiac complications of 24-hour floururacil infusion, especially in patients with a history of heart disease, careful cardiac monitoring during hospitalization is recommended.
{"title":"The rate of cardiac complications in patients receiving a 24-hour dose of 5-Fluorouracil","authors":"Mostafa Davoodnataj, Mohsen Vakili Sadeghi, Naghmeh Zieaie Amiri, Majid Nabipour, Hemmat Gholinia Ahangar","doi":"10.34172/mj.2023.044","DOIUrl":"https://doi.org/10.34172/mj.2023.044","url":null,"abstract":"Background. Cardiotoxicity caused by fluoropyrimidines is an uncommon but potentially fatal complication. Its frequency has been 1.6 to 19% in previous studies. But there are no accurate statistics in Iran. The aim of this study was to determine the rate of cardiac complications of 5-fluorouracil (5-FU) infusion. Methods. This prospective study was conducted in patients with gastrointestinal cancers who underwent chemotherapy with regimens containing 24-hour infusion of 5-FU at Rohani Hospital of Babol. Patients with a history of radiation therapy to the chest or epigastrium or suffering from COVID-19 disease in the last 6 weeks were excluded from the study. Each patient was examined in 2 cycles of chemotherapy. In case of complications, cardiac examinations including examination, electrocardiogram, echocardiography and if necessary, coronary angiography were done. Data analysis was done with SPSS 26 software using descriptive indices and Fisher exact test (significance≤0.05). Results. In sixty one patients, 122 courses of chemotherapy were evaluated. Underlying cancer was colorectal cancer in 32 patients, stomach cancer in people. Eight patients (13.11%) had cardiac complication, in eleven chemotherapy cycles, included 7 cases of chest pain and one case of each of complications of myocardial infarction, pulmonary edema and pericarditis. Four out of 8 patients suffered from complications only in the first round, one only in the second round and three patients in both rounds of chemotherapy (P=0.004).The incidence rate of complications in patients without a history of heart disease was 8.7% and in patients with a history of heart disease 26.7%(P=0.073), in non-smokers 10% and in smokers 30%(P=0.084). It was 10.6% in non-diabetic patients and 21.4% in diabetic patients (P=0.294). Conclusion. Cardiac complications are common in 24-hour injection of 5-fluorouracil. A patient who has a heart complication once, might have a higher probability of having a complication in the next cycles. Practical Implications. Due to the high prevalence of cardiac complications of 24-hour floururacil infusion, especially in patients with a history of heart disease, careful cardiac monitoring during hospitalization is recommended.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The three primary differential diagnoses for a patient with systemic and hematological involvements (fever, lymphadenopathy, and hepatosplenomegaly), skin rashes, and sore pharynx are infections, connective tissue diseases, and malignancies. In this case report, we discuss possible illusory similarities between these categories that can aid in the diagnostic workup of primary care physicians. Practical Implications. The clinical course of (Infections mononncleosis, MI) patients with and their histopathological data rarely differ; Therefore, early testing for IM caused by EBV is recommended. This article will help physicians face similar cases
{"title":"Presentation of a case with fever, lymphadenopathy and thrombocytopenia: a case report","authors":"Maassoumeh Akhlaghi, Kiarash Kazemi, Soheila Sobhani","doi":"10.34172/mj.2023.048","DOIUrl":"https://doi.org/10.34172/mj.2023.048","url":null,"abstract":"The three primary differential diagnoses for a patient with systemic and hematological involvements (fever, lymphadenopathy, and hepatosplenomegaly), skin rashes, and sore pharynx are infections, connective tissue diseases, and malignancies. In this case report, we discuss possible illusory similarities between these categories that can aid in the diagnostic workup of primary care physicians. Practical Implications. The clinical course of (Infections mononncleosis, MI) patients with and their histopathological data rarely differ; Therefore, early testing for IM caused by EBV is recommended. This article will help physicians face similar cases","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders. This study, for the first time, explored the possible effects of this chalcone on high-fat emulsion-induced pancreatic abnormalities in rats. Methods. Twenty-one male rats were randomly assigned into three groups: control (received 10% tween 80); HFD (received high-fat emulsion + 10% tween 80); and HFD + chalcone (received high-fat emulsion + trans-chalcone). Real-time PCR was used to assess pancreatic mRNA expression levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor α (TNF-α) in the pancreas of all rats. Results. High-fat emulsion increased the mRNA expression levels of inflammatory biomarkers, including TNF-α and MCP-1 in the pancreas of rats, and treatment with trans-chalcone prevented these high-fat emulsion-induced changes. Conclusion. trans-Chalcone can protect the pancreas of male rats against HFD-induced abnormalities through its anti-inflammatory effects. Practical Implications. It seems that consumption of HFD up-regulates the production of inflammatory mediators in the pancreas. On the other hand, trans-chalcone can ameliorate HFD-related pancreatic inflammation.
{"title":"trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression","authors":"Elham Karimi-Sales, Mohammad Reza Alipour","doi":"10.34172/mj.2023.042","DOIUrl":"https://doi.org/10.34172/mj.2023.042","url":null,"abstract":"Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders. This study, for the first time, explored the possible effects of this chalcone on high-fat emulsion-induced pancreatic abnormalities in rats. Methods. Twenty-one male rats were randomly assigned into three groups: control (received 10% tween 80); HFD (received high-fat emulsion + 10% tween 80); and HFD + chalcone (received high-fat emulsion + trans-chalcone). Real-time PCR was used to assess pancreatic mRNA expression levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor α (TNF-α) in the pancreas of all rats. Results. High-fat emulsion increased the mRNA expression levels of inflammatory biomarkers, including TNF-α and MCP-1 in the pancreas of rats, and treatment with trans-chalcone prevented these high-fat emulsion-induced changes. Conclusion. trans-Chalcone can protect the pancreas of male rats against HFD-induced abnormalities through its anti-inflammatory effects. Practical Implications. It seems that consumption of HFD up-regulates the production of inflammatory mediators in the pancreas. On the other hand, trans-chalcone can ameliorate HFD-related pancreatic inflammation.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate a case of neuro-Behçet’s disease misdiagnosed as acute ischemic stroke or multiple sclerosis (MS). The studied case was a 29-year-old man with subacute onset of hemiparesis, dysarthria, and ataxia who was diagnosed as acute ischemic stroke at first. Due to no significant improvement, the patient was managed as an MS case, but he did not experience any improvements again. We noticed a history of oral and genital aphthous and cascade sign appearance in his brain MRI. Then, Behçet’s disease with secondary parenchymal involvement of brainstem was confirmed. The patient received infliximab, which resulted in clinico-radiological recovery. Practical Implications. Given the prevalence of Behçet’s disease in the Middle East, the possibility of its diagnosis should be considered in patients with atypical history or imaging for ischemic stroke or MS.
{"title":"Evaluating the diagnosis and treatment of neuro-Behçet’s disease with cascade sign appearance in brainstem: a case report","authors":"Samaneh Hosseini, Alireza Khabazi, Mehran Ghaffari, Seyed Hossein Aghamiri","doi":"10.34172/mj.2023.040","DOIUrl":"https://doi.org/10.34172/mj.2023.040","url":null,"abstract":"This study aimed to investigate a case of neuro-Behçet’s disease misdiagnosed as acute ischemic stroke or multiple sclerosis (MS). The studied case was a 29-year-old man with subacute onset of hemiparesis, dysarthria, and ataxia who was diagnosed as acute ischemic stroke at first. Due to no significant improvement, the patient was managed as an MS case, but he did not experience any improvements again. We noticed a history of oral and genital aphthous and cascade sign appearance in his brain MRI. Then, Behçet’s disease with secondary parenchymal involvement of brainstem was confirmed. The patient received infliximab, which resulted in clinico-radiological recovery. Practical Implications. Given the prevalence of Behçet’s disease in the Middle East, the possibility of its diagnosis should be considered in patients with atypical history or imaging for ischemic stroke or MS.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136194205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. The irisin and betatrophin hormones are involved in insulin resistance. Considering the muscle weakness of elderly diabetics, this study aimed to investigate the effect of 21 weeks of strength training on betatrophin and irisin serum levels in type 2 diabetic elderly men. Methods. This semi-experimental study was conducted on type 2 diabetic men with an average age of 70.85±2.90 years. The strength training protocol was performed twice a week for 21 weeks. The exercises consisted of three stages: 1- muscle endurance, 2- muscle hypertrophy, and 3- maximum strength training. Fasting blood glucose levels and serum levels of insulin, betatrophin, and irisin were measured in two phases before and after the exercises. Results. The serum levels of insulin, irisin, and betatrophin in the diabetes control group were lower than in the healthy group (P<0.05) and 21 weeks of strength training increased the serum levels of insulin, irisin, and betatrophin, and decreased body weight and fasting blood glucose levels in elderly diabetic men compared to the control group (P<0.05). Conclusion. Strength training improved metabolic disorders in diabetics and increased secretion of irisin and betatrophin following exercise which indicated that exercise may have a protective mechanism in diabetes. Practical Implications. Stationary movements by performing strength activities, through the development of skeletal muscles of diabetics, improve insulin sensitivity and harvest more glucose in the body. In addition, these exercises can be a protective mechanism to prevent or delay the complications of type 2 diabetes by increasing irisin and betatrophin levels.
{"title":"The effect of long-term strength training on serum levels of betatrophin and irisin in elderly men with type 2 diabetes","authors":"Mirabdullah Tahramuzi, Farnaz Seifi-Skishahr, Roghayyeh Afroundeh, Leila Katebi, Reza Farzi zadeh","doi":"10.34172/mj.2023.036","DOIUrl":"https://doi.org/10.34172/mj.2023.036","url":null,"abstract":"Background. The irisin and betatrophin hormones are involved in insulin resistance. Considering the muscle weakness of elderly diabetics, this study aimed to investigate the effect of 21 weeks of strength training on betatrophin and irisin serum levels in type 2 diabetic elderly men. Methods. This semi-experimental study was conducted on type 2 diabetic men with an average age of 70.85±2.90 years. The strength training protocol was performed twice a week for 21 weeks. The exercises consisted of three stages: 1- muscle endurance, 2- muscle hypertrophy, and 3- maximum strength training. Fasting blood glucose levels and serum levels of insulin, betatrophin, and irisin were measured in two phases before and after the exercises. Results. The serum levels of insulin, irisin, and betatrophin in the diabetes control group were lower than in the healthy group (P<0.05) and 21 weeks of strength training increased the serum levels of insulin, irisin, and betatrophin, and decreased body weight and fasting blood glucose levels in elderly diabetic men compared to the control group (P<0.05). Conclusion. Strength training improved metabolic disorders in diabetics and increased secretion of irisin and betatrophin following exercise which indicated that exercise may have a protective mechanism in diabetes. Practical Implications. Stationary movements by performing strength activities, through the development of skeletal muscles of diabetics, improve insulin sensitivity and harvest more glucose in the body. In addition, these exercises can be a protective mechanism to prevent or delay the complications of type 2 diabetes by increasing irisin and betatrophin levels.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136045137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Paying attention to the spread of Corona in the last few years and the problems related to the health of hospital employees is very important. This research was conducted with the aim of modeling health-oriented behavior patterns based on abnormal personality traits with mediating role of health beliefs in the period of the COVID-19 pandemic. Methods. The research method of this study was descriptive-correlation and structural equation modeling. The statistical population included the personnel of Al-Zahra State Hospital in Isfahan, of which 385 people were selected based on a convenience sampling method. The research tools included the personality abnormal dimensions questionnaire (PID-5), the health belief scale and health-oriented behavioral patterns. Pearson's correlation coefficient (with SPSS.23 software) and structural equation modeling (SMART PLS.3) were used for data analysis. Results. There was a relationship between abnormal personality traits and health-oriented behavior patterns during the COVID-19 pandemic period (β=0.47 and P<0.01). There was a relationship between health beliefs and health-oriented behavioral patterns during the COVID-19 pandemic period (β=0.223 and P<0.01). However, the mediating role of health beliefs in the relationship between abnormal personality traits and health-oriented behavioral patterns was not significant (β=0.026 and P<0.05). Conclusion. Abnormal personality traits had a direct effect on health-oriented behavioral patterns. Practical Implications. Paying attention to the destructive role of the corona virus in all aspects of people's lives, especially the medical staff and the role of medical staff in caring for and improving the physical and mental condition of patients can show its importance in the results of this research.
{"title":"Modeling health-oriented behavior patterns based on abnormal personality traits with mediating role of health beliefs in the period of the COVID-19 pandemic","authors":"Parisa Nasiri, Reza Abdi, Gholamreza Chalabianlou","doi":"10.34172/mj.2023.038","DOIUrl":"https://doi.org/10.34172/mj.2023.038","url":null,"abstract":"Background. Paying attention to the spread of Corona in the last few years and the problems related to the health of hospital employees is very important. This research was conducted with the aim of modeling health-oriented behavior patterns based on abnormal personality traits with mediating role of health beliefs in the period of the COVID-19 pandemic. Methods. The research method of this study was descriptive-correlation and structural equation modeling. The statistical population included the personnel of Al-Zahra State Hospital in Isfahan, of which 385 people were selected based on a convenience sampling method. The research tools included the personality abnormal dimensions questionnaire (PID-5), the health belief scale and health-oriented behavioral patterns. Pearson's correlation coefficient (with SPSS.23 software) and structural equation modeling (SMART PLS.3) were used for data analysis. Results. There was a relationship between abnormal personality traits and health-oriented behavior patterns during the COVID-19 pandemic period (β=0.47 and P<0.01). There was a relationship between health beliefs and health-oriented behavioral patterns during the COVID-19 pandemic period (β=0.223 and P<0.01). However, the mediating role of health beliefs in the relationship between abnormal personality traits and health-oriented behavioral patterns was not significant (β=0.026 and P<0.05). Conclusion. Abnormal personality traits had a direct effect on health-oriented behavioral patterns. Practical Implications. Paying attention to the destructive role of the corona virus in all aspects of people's lives, especially the medical staff and the role of medical staff in caring for and improving the physical and mental condition of patients can show its importance in the results of this research.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135052505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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