Eva Krieghoff-Henning, Juliane Folkerts, Andrea Penzkofer, Susanne Weg-Remers
Cancer is characterized by proliferation of cells that have managed to evade central endogenous control mechanisms. Cancers are grouped according to their organ or tissue of origin, but increasingly also based on molecular characteristics of the respective cancer cells. Due to the rapid technological advances of the last years, it is now possible to analyze the molecular makeup of different cancer types in detail within short time periods. The accumulating knowledge about development and progression of cancer can be used to develop more precise diagnostics and more effective and/or less toxic cancer therapies. In the long run, the goal is to offer to every cancer patient a therapeutic regimen that is tailored to his individual disease and situation in an optimal way.
{"title":"Cancer – an overview.","authors":"Eva Krieghoff-Henning, Juliane Folkerts, Andrea Penzkofer, Susanne Weg-Remers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cancer is characterized by proliferation of cells that have managed to evade central endogenous control mechanisms. Cancers are grouped according to their organ or tissue of origin, but increasingly also based on molecular characteristics of the respective cancer cells. Due to the rapid technological advances of the last years, it is now possible to analyze the molecular makeup of different cancer types in detail within short time periods. The accumulating knowledge about development and progression of cancer can be used to develop more precise diagnostics and more effective and/or less toxic cancer therapies. In the long run, the goal is to offer to every cancer patient a therapeutic regimen that is tailored to his individual disease and situation in an optimal way.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 2","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer is by far the most common malignancy in women. The median age is 64 years. Stage at diagnosis and biological features determine the prognosis. Patients with early breast cancer, with locally advanced disease and with locoregional relapse can be cured. Modern treatment is multimodal. It includes surgery, radiation and drug therapy. Patients with metastatic disease are treated with palliative intent. Aims are alleviation of symptoms and prolongation of survival. Breast cancer specific mortality has continually decreased in the past 10 years. Five year survival rate is 87% in Germany. Patients with early breast cancer have an even higher chance of cure.
{"title":"Breast cancer: basics, screening, diagnostics and treatment.","authors":"Bernhard Wörmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Breast cancer is by far the most common malignancy in women. The median age is 64 years. Stage at diagnosis and biological features determine the prognosis. Patients with early breast cancer, with locally advanced disease and with locoregional relapse can be cured. Modern treatment is multimodal. It includes surgery, radiation and drug therapy. Patients with metastatic disease are treated with palliative intent. Aims are alleviation of symptoms and prolongation of survival. Breast cancer specific mortality has continually decreased in the past 10 years. Five year survival rate is 87% in Germany. Patients with early breast cancer have an even higher chance of cure.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 2","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}