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Natural Polysaccharides in Drug Delivery and Biomedical Applications最新文献

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Development and Characterization of Sustainable Antimicrobial Films Incorporated with Natamycin and Cellulose Nanocrystals for Cheese Preservation 纳他霉素和纤维素纳米晶复合抗菌膜的制备与表征
Pub Date : 2023-01-21 DOI: 10.3390/polysaccharides4010004
M. D. Sousa, Vânia Miria C. Clemente, Rosilene Maria de S. Santos, M. Oliveira, José Osvaldo Ramos Silva, Laís Fernanda Batista, C. Marques, A. Souza, E. Medeiros, N. Soares
Environmental pollution and food safety are both issues of global concern. In this sense, sustainable and antimicrobial nanocomposites based on cellulose/poly (vinyl alcohol) blend incorporated with natamycin and cellulose nanocrystals (CNC) were manufactured and characterized. The developed films were evaluated according to their mechanical and optical properties, and their barrier to oxygen and water vapor permeation. The antimycotic activity was evaluated in vitro against fungi and yeasts. The film’s potential to act as an active packaging for Minas cheese preservation was also assessed. The incorporation of CNC increased the films’ tensile strength; however, it did not influence the barrier properties to water vapor (4.12 × 10−7 g·cm.m−1·h−1·Pa−1) and oxygen (3.64 × 10−13 g·cm·m−1·h−1·Pa−1). The incorporation of natamycin, on the other hand, resulted in films that were more opaque (around 24%) and of a yellowish color. The active nanocomposites developed showed antimicrobial effects against all analyzed fungi and yeasts (approximately 35 mm of inhibition zone) and were able to control the growth of S. cerevisiae in cheese, reducing a log cycle until the 12th day of storage. Since they performed well in vitro and on food, it was concluded that the films showed potential to be applied in Minas cheese preservation.
环境污染和食品安全都是全球关注的问题。在这种意义上,基于纤维素/聚乙烯醇共混物与纳他霉素和纤维素纳米晶体(CNC)的可持续和抗菌纳米复合材料被制造和表征。根据显影膜的力学性能、光学性能、阻氧性和水蒸气渗透性对显影膜进行了评价。体外对真菌和酵母进行了抑菌活性评价。还评估了该薄膜作为米纳斯奶酪保存的活性包装的潜力。CNC的加入提高了薄膜的抗拉强度;然而,它对水蒸气(4.12 × 10−7 g·cm.m−1·h−1·Pa−1)和氧气(3.64 × 10−13 g·cm·m−1·h−1·Pa−1)的阻隔性能没有影响。另一方面,纳他霉素的掺入使胶片更不透明(约24%),颜色偏黄。所开发的活性纳米复合材料对所分析的所有真菌和酵母(约35 mm的抑制区)都有抗菌作用,并且能够控制酿酒酵母在奶酪中的生长,减少1个对数周期,直到储存第12天。由于该膜在体外和食品上均表现良好,因此具有应用于米纳斯奶酪保鲜的潜力。
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引用次数: 1
Acknowledgment to the Reviewers of Polysaccharides in 2022 向2022年《多糖》审稿人致谢
Pub Date : 2023-01-17 DOI: 10.3390/polysaccharides4010003
High-quality academic publishing is built on rigorous peer review [...]
高质量的学术出版建立在严格的同行评审的基础上[…]
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引用次数: 0
Anthocyanin-Rich Jamun (Syzygium cumini L.) Pulp Transported on Protein-Coated Ionic Gelation Microparticles of Calcium Alginate: Production and Morphological Characteristics 花青素丰富的Jamun (Syzygium cumini L.)海藻酸钙蛋白包被离子凝胶微粒子的浆体运输:生产和形态特征
Pub Date : 2023-01-11 DOI: 10.3390/polysaccharides4010002
Vitor Renan da Silva, Gislaine Ferreira Nogueira, C. Soares, R. A. D. Oliveira
Jamun (Syzygium cumini L.) is a fruit rich in anthocyanins, an important group of natural pigments, with color ranging from red to blue, soluble in water, highly antioxidant. Despite its great potential for use as a natural dye, its application is a challenge, due to the instability of these compounds in the environmental conditions of processing and storage commonly used by the food industry. Therefore, this study evaluated the microencapsulation of anthocyanin-rich jamun pulp by ionic gelation (IG) and its protein-coating by electrostatic interaction (PC). The effect of the ratio of sodium alginate solids and jamun pulp (1:0.40 to 1:2, w/w) and the concentration of gelatin coating solution (0% to 10%, w/w) on the morphology, water and total protein content and anthocyanins content in the microparticles were evaluated. Visually, the IG particles showed color tones ranging from reddish to purplish, which became less intense and opaque after being submitted to the gelatin coating process. Microscopic images demonstrated that microparticles formed had an irregular and heterogeneous shape with disorganized gel network formation is due to the presence of solid structures of jamun pulp, observed within the microparticles. The greater the concentration of gelatin in the coating solution, the greater the protein adsorption for the formation of the protective layer, ranging from 21.82 ± 0.72% (T1) to 55.87 ± 4.23% (T6). Protein adsorption on the GI resulted in a decrease in moisture content (ranging from 87.04 ± 0.22 to 97.06 ± 0.12%) and anthocyanins contents (ranging from 5.84 ± 0.62 to 0.78 ± 0.14%) in the PC microparticles.
Jamun (Syzygium cumini L.)是一种富含花青素的水果,花青素是一种重要的天然色素,颜色从红色到蓝色不等,可溶于水,具有很强的抗氧化性。尽管其作为天然染料的巨大潜力,但由于这些化合物在食品工业通常使用的加工和储存环境条件下的不稳定性,其应用是一个挑战。因此,本研究利用离子凝胶(IG)对富含花青素的jamun果肉进行微胶囊化,并利用静电相互作用(PC)对其进行蛋白包被。考察了海藻酸钠固体与jamun浆的比例(1:0.40 ~ 1:2,w/w)和明胶包衣液的浓度(0% ~ 10%,w/w)对微球形貌、微球中水分、总蛋白含量和花青素含量的影响。从视觉上看,IG颗粒呈现出从红色到紫色的色调,在进行明胶涂层处理后,颜色变得不那么强烈和不透明。显微图像显示,形成的微颗粒具有不规则和不均匀的形状,无序的凝胶网络形成是由于微颗粒内观察到的jamun纸浆固体结构的存在。涂层溶液中明胶的浓度越大,蛋白质对保护层形成的吸附越大,其吸附范围为21.82±0.72% (T1) ~ 55.87±4.23% (T6)。蛋白质在GI上的吸附导致PC微粒的水分含量(范围为87.04±0.22 ~ 97.06±0.12%)和花青素含量(范围为5.84±0.62 ~ 0.78±0.14%)下降。
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引用次数: 2
Potential Biomedical Applications of Modified Pectin as a Delivery System for Bioactive Substances 改性果胶作为生物活性物质递送系统的潜在生物医学应用
Pub Date : 2023-01-01 DOI: 10.3390/polysaccharides4010001
F. Odun-Ayo, L. Reddy
Pectin is a polysaccharide that has been recently gaining attention because it is renewable, inexpensive, biocompatible, degradable, non-toxic, non-polluting, and has mechanical integrity. The recent extraction techniques and modification to the structural property of pectin have led to the modified pectin whose chemical and surface functional groups yield galacturonic acid and galactose contents which are primarily responsible for its improved and better use in biomedical applications including drug delivery and thus producing high-value products. Major attention on modified pectin has been focused on the aspect of its bioactive functionalities that opposes cancer development. Nevertheless, modified pectin can be combined with a wide range of biopolymers with unique characteristics and activities which thus enhances its application in different areas. This has enabled the current applications of modified pectin through different approaches in addition to the prominent anti-cancer functional capabilities, which were reviewed. Furthermore, this paper highlights the potential of modified pectin as a delivery system of bioactive substances, its synergistic and prebiotic effects, gut microbiota effect and antiviral properties amongst other roles applicable in the biomedical and pharmaceutical industries.
果胶是近年来备受关注的一种多糖,因为它具有可再生、廉价、生物相容性、可降解、无毒、无污染、机械完整性等特点。最近的提取技术和对果胶结构性质的改性使改性果胶的化学和表面官能团产生半乳糖醛酸和半乳糖,这主要是改善和更好地用于生物医学应用,包括药物输送,从而生产高价值产品。人们对改性果胶的关注主要集中在其抗肿瘤的生物活性方面。然而,改性果胶可以与多种具有独特特性和活性的生物聚合物结合,从而增强了其在不同领域的应用。这使得目前改性果胶除了具有突出的抗癌功能外,还可以通过不同的途径进行应用。此外,本文强调了改性果胶作为生物活性物质的传递系统的潜力,它的协同作用和益生元效应,肠道微生物群效应和抗病毒特性以及其他应用于生物医学和制药行业的作用。
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引用次数: 6
Photo-Curing Chitosan-g-N-Methylolacrylamide Compositions: Synthesis and Characterization 光固化壳聚糖-g- n-甲基丙烯酰胺组合物:合成与表征
Pub Date : 2022-12-18 DOI: 10.3390/polysaccharides3040049
S. Uspenskii, V. Potseleev, E. Svidchenko, G. Goncharuk, A. Zelenetskii, T. Akopova
Chitosan is one of the promising compounds for use in various fields of medicine. However, for successful application, materials based on it must be insoluble in water and have specified physical and mechanical properties. In this work, we studied the interaction of N-methylolacrylamide (NMA) and chitosan upon concentration of the solutions, both under the action of UV radiation and without it, which results in curing of the polymer matrix. The main products, proposed mechanisms of the crosslinking reaction, and the influence of external conditions on these processes have been revealed using NMR, IR, and UV spectroscopy. It was found that the reaction proceeds along three pathways. The main reactions proceed with the amino groups of chitosan, and the hydroxymethyl and vinyl groups of NMA. Studies have shown that for the formation of insoluble materials based on chitosan, the best content in the initial cast solution is 2 wt% of chitosan at 0.25 wt% concentration of NMA. Films formed from such solutions possessed high strength and deformation characteristics, namely an elastic modulus of about 1500 GPa, a strength of about 30 MPa, and an elongation at break of about 100%.
壳聚糖是一种具有广阔应用前景的化合物。然而,为了成功应用,基于它的材料必须不溶于水,并具有特定的物理和机械性能。在本研究中,我们研究了n -甲基丙烯酰胺(NMA)和壳聚糖在紫外辐射和无紫外辐射作用下的相互作用对聚合物基体固化的影响。通过核磁共振、红外和紫外光谱分析,揭示了交联反应的主要产物,提出了交联反应的机理,以及外界条件对交联反应的影响。研究发现,该反应沿着三条途径进行。主要反应发生在壳聚糖的氨基和NMA的羟甲基和乙烯基上。研究表明,以壳聚糖为基础制备不溶性材料,在0.25 wt%的NMA浓度下,初始铸液中壳聚糖的最佳含量为2 wt%。该溶液形成的膜具有较高的强度和变形特性,弹性模量约为1500 GPa,强度约为30 MPa,断裂伸长率约为100%。
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引用次数: 0
Skin Health Promoting Effects of Natural Polysaccharides and Their Potential Application in the Cosmetic Industry 天然多糖对皮肤健康的促进作用及其在化妆品工业中的潜在应用
Pub Date : 2022-12-14 DOI: 10.3390/polysaccharides3040048
Yu-Xiu Yao, Baojun Xu
Skincare is one of the most profitable product categories today. Consumers’ demand for skin-friendly products has stimulated the development of natural-ingredient-based cosmeceutical preparations over synthetic chemicals. Thus, natural polysaccharides have gained much attention since the promising potent efficacy in wound healing, moisturizing, antiaging, and whitening. The challenge is to raise awareness of polysaccharides with excellent bioactivities from natural sources and consequently incorporate them in novel and safer cosmetics. This review highlights the benefits of natural polysaccharides from plants, algae, and fungi on skin health, and points out some obstacles in the application of natural polysaccharides.
护肤品是当今最赚钱的产品类别之一。消费者对亲肤产品的需求刺激了以天然成分为基础的药妆制剂的发展,而不是合成化学品。因此,天然多糖因其在伤口愈合、保湿、抗衰老和美白等方面的潜在功效而备受关注。我们面临的挑战是提高人们对天然来源的具有优异生物活性的多糖的认识,从而将它们纳入新颖和更安全的化妆品中。本文综述了植物、藻类和真菌中天然多糖对皮肤健康的益处,并指出了天然多糖应用中的一些障碍。
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引用次数: 4
Reactive Extrusion-Assisted Process to Obtain Starch Hydrogels through Reaction with Organic Acids 反应挤出辅助工艺与有机酸反应制备淀粉水凝胶
Pub Date : 2022-12-05 DOI: 10.3390/polysaccharides3040046
B. M. Marim, J. Mantovan, Gina Alejandra Gil-Giraldo, Jéssica F Pereira, B. Simões, F. Yamashita, S. Mali
A totally green process based on reactive extrusion was used for the production of cassava starch hydrogels through reaction with two organic crosslinking agents, citric (CA) and tartaric (TA) acids. CA and TA were used at different concentrations (0, 2.5, 5.0, 10.0, 15.0, and 20.0%). Degree of substitution (DS) of hydrogels ranged from 0.023 to 0.365. Fourier transform infrared spectroscopy results showed a new band appearing at 1730 cm−1 associated with ester carbonyl groups. X-ray diffraction indicated that reactive extrusion resulted in the disappearance of diffraction peaks of native starch and samples with lower crystallinity indices ranging from 37% (native starch) to 8–11% in starch hydrogels. Morphology analysis showed that the original granular structure of starch was lost and replaced by a rougher and irregular structure. Water holding capacity values of starch hydrogels obtained by reactive extrusion were superior to those of native starch and the control sample (extruded without the crosslinking agents). Hydrogels obtained with the highest CA or TA concentration (20.0%) resulted in the higher DS and swelling capacities, resulting in samples with 870 and 810% of water retention, respectively. Reactive extrusion was effective in obtaining starch hydrogels by reaction with organic acids.
采用反应挤出法与柠檬酸和酒石酸两种有机交联剂反应制备木薯淀粉水凝胶。CA和TA的浓度分别为0、2.5、5.0、10.0、15.0和20.0%。水凝胶的取代度(DS)范围为0.023 ~ 0.365。傅里叶变换红外光谱结果表明,在1730 cm−1处出现了一个与酯羰基相关的新波段。x射线衍射结果表明,反应挤压导致天然淀粉的衍射峰消失,淀粉水凝胶中结晶度指数较低,为37%(天然淀粉)至8-11%。形貌分析表明,淀粉原有的颗粒状结构丢失,取而代之的是更粗糙、不规则的结构。反应挤出法得到的淀粉水凝胶的持水能力值优于天然淀粉和对照样品(未添加交联剂)。CA或TA浓度最高(20.0%)的水凝胶具有更高的DS和膨胀能力,样品的保水率分别为870%和810%。反应挤出与有机酸反应制备淀粉水凝胶是有效的。
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引用次数: 2
The Role of Starch in Shaping the Rheo-Mechanical Properties of Fat-in-Water Emulsions 淀粉对水包脂肪乳剂流变力学性能的影响
Pub Date : 2022-12-05 DOI: 10.3390/polysaccharides3040047
R. Rezler
The DMA technique was used to conduct experiments on the rheo-mechanical properties of emulsified bovine fat meat products stabilised with potato starch. Starch gels with starch concentrations corresponding to the concentration of starch in water in the emulsions under analysis were used as control systems. The research showed that the rheo-mechanical properties of starch gels and starch–fat gels result from the conformational changes occurring within the structural elements of their spatial network. In starch gels, segments formed by complex associations of amylose chains are structural elements, whereas in starch–fat gels (emulsions) these are additionally amylose–fat complexes. Changes occurring during progressive retrogradation increase the degree of cross-linking in them. In starch gels, they are conditioned by the starch concentration, whereas in emulsions they are conditioned by the concentration of starch and the presence of fat. The parameters obtained by adjusting the Avrami equation to the data obtained with the DMA method enabled the determination of three forms of organisation of the dispersion structure of starch–fat systems. Each of these forms of structure organisation is conditioned by the concentration of starch in the emulsion system.
采用DMA技术对马铃薯淀粉稳定乳化牛脂肪肉制品的流变力学性能进行了研究。用淀粉凝胶作为控制系统,其淀粉浓度与所分析乳剂中淀粉在水中的浓度相对应。研究表明,淀粉凝胶和淀粉-脂肪凝胶的流变力学性能是由其空间网络结构元素内部的构象变化引起的。在淀粉凝胶中,直链链复杂结合形成的片段是结构元件,而在淀粉-脂肪凝胶(乳液)中,这些是额外的直链-脂肪复合物。进行性退化过程中发生的变化增加了它们的交联程度。在淀粉凝胶中,它们由淀粉浓度决定,而在乳剂中,它们由淀粉浓度和脂肪的存在决定。通过将Avrami方程与DMA法得到的数据进行调整得到的参数,可以确定淀粉-脂肪体系分散结构的三种组织形式。每一种形式的结构组织都是由淀粉在乳液体系中的浓度决定的。
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引用次数: 1
Cellulose-Based Light-Management Films with Improved Properties Directly Fabricated from Green Tea 直接以绿茶为原料制备性能改善的纤维素基光管理薄膜
Pub Date : 2022-12-02 DOI: 10.3390/polysaccharides3040045
Jianfeng Peng, Xiaoqian Ji, Xinqun Xia, Cuiyue Li, Zhaoning Wei, Chen Chu, Zhen Xu, Jun Zhang, Guangmei Xia
Tea polyphenols are a phenolic bioactive compound extracted from tea leaves and have been widely used as additives to prepare functional materials used in packaging, adsorption and energy fields. Nevertheless, tea polyphenols should be extracted first from the leaves before use, leading to energy consumption and the waste of tea. Therefore, completely and directly utilizing the tea leaf to fabricate novel composite materials is more attractive and meaningful. Herein, semi-transparent green-tea-based all-biomass light-management films with improved strength, a tunable haze (60–80%) and UV-shielding properties (24.23% for UVA and 4.45% for UVB) were directly manufactured from green tea by adding high-degree polymerization wood pulps to form entanglement networks. Additionally, the green-tea-based composite films can be produced on a large scale by adding green tea solution units to the existing continuous production process of pure cellulose films. Thus, a facile and feasible approach was proposed to realize the valorization of green tea by preparing green-tea-based all-biomass light-management films that have great prospects in flexible devices and energy-efficient buildings.
茶多酚是从茶叶中提取的一种酚类生物活性化合物,作为添加剂被广泛用于制备包装、吸附和能源等领域的功能材料。然而,茶多酚在使用前应先从茶叶中提取,导致能源消耗和茶的浪费。因此,完全直接利用茶叶制造新型复合材料更具吸引力和意义。本文以绿茶为原料,通过加入高度聚合的木浆形成纠缠网络,直接制备了具有增强强度、可调雾度(60-80%)和紫外线屏蔽性能(UVA 24.23%和UVB 4.45%)的半透明绿茶基全生物质光管理膜。此外,在现有的纯纤维素膜连续生产工艺中加入绿茶溶液单元,可以大规模生产绿茶基复合膜。因此,提出了一种简便可行的方法来实现绿茶的增值,即制备绿茶基全生物质光管理膜,在柔性设备和节能建筑中具有很大的前景。
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引用次数: 1
Polysaccharide-Based Biodegradable Films: An Alternative in Food Packaging 以多糖为基础的可生物降解薄膜:食品包装的一种替代品
Pub Date : 2022-11-25 DOI: 10.3390/polysaccharides3040044
E. Díaz-Montes
Packaging can mitigate the physical, chemical, and microbiological phenomena that affects food products’ quality and acceptability. However, the use of conventional packaging from non-renewable fossil sources generates environmental damage caused by the accumulation of non-biodegradable waste. Biodegradable films emerge as alternative biomaterials which are ecologically sustainable and offer protection and increase food product shelf life. This review describes the role of biodegradable films as packaging material and their importance regarding food quality. The study emphasizes polysaccharide-based biodegradable films and their use in foods with different requirements and the advances and future challenges for developing intelligent biodegradable films. In addition, the study explores the importance of the selection of the type of polysaccharide and its combination with other polymers for the generation of biodegradable films with functional characteristics. It also discusses additives that cause interactions between components and improve the mechanical and barrier properties of biodegradable films. Finally, this compilation of scientific works shows that biodegradable films are an alternative to protecting perishable foods, and studying and understanding them helps bring them closer to replacing commercial synthetic packaging.
包装可以减轻影响食品质量和可接受性的物理、化学和微生物现象。然而,使用来自不可再生化石资源的常规包装会产生不可生物降解废物的积累,从而造成环境破坏。生物可降解薄膜作为一种生态可持续的替代生物材料,为食品提供保护和延长保质期。本文综述了可生物降解薄膜作为包装材料的作用及其对食品质量的重要性。重点介绍了基于多糖的生物降解膜及其在不同要求食品中的应用,以及智能生物降解膜的研究进展和未来面临的挑战。此外,本研究还探讨了多糖类型的选择及其与其他聚合物的结合对于生成具有功能特征的可生物降解膜的重要性。还讨论了引起组分之间相互作用并改善生物可降解膜的机械和阻隔性能的添加剂。最后,这篇科学著作的汇编表明,生物可降解薄膜是保护易腐食品的另一种选择,研究和理解它们有助于使它们更接近于取代商业合成包装。
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引用次数: 6
期刊
Natural Polysaccharides in Drug Delivery and Biomedical Applications
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