Pub Date : 2021-09-18DOI: 10.3390/polysaccharides2030043
I. Macêdo, M. Cereda, C. D. Bet, J. F. S. S. Junior, M. Carvalho, E. Gil
Food frauds present a major problem in the foodstuff industry. Arrowroot and cassava may be targeted in adulteration and falsification processes. Raman analysis combined with chemometric techniques was proposed to identify the mixing and adulteration of these foodstuffs in commercial products. 67 cassava and 5 arrowroot samples were prepared in laboratory. 21 cassava and 5 arrowroot commercial samples were purchased in local stores. Raman assays were performed in the range of 400 to 2300 cm−1. Principal component analysis with K-means clustering was used to identify the adulteration of these products. It was possible to observe the separation of three different groups in the data, these groups labelled group 1, 2 and 3 were correspondent to cassava-like samples, mixed samples, and arrowroot-like samples, respectively. Despite the visual analysis related to sensory characteristics and the visual analysis of each Raman spectrum of cassava and arrowroot not being able to differentiate these foodstuffs, the chemometric approaches with the Raman specters data were able to identify which samples were pure arrowroot, pure cassava and which were mixed products. The proposed approach showed to be an effective tool in the investigation of fraud for arrowroot and cassava.
{"title":"Arrowroot and Cassava Mixed Starch Products Identification by Raman Analysis with Chemometrics","authors":"I. Macêdo, M. Cereda, C. D. Bet, J. F. S. S. Junior, M. Carvalho, E. Gil","doi":"10.3390/polysaccharides2030043","DOIUrl":"https://doi.org/10.3390/polysaccharides2030043","url":null,"abstract":"Food frauds present a major problem in the foodstuff industry. Arrowroot and cassava may be targeted in adulteration and falsification processes. Raman analysis combined with chemometric techniques was proposed to identify the mixing and adulteration of these foodstuffs in commercial products. 67 cassava and 5 arrowroot samples were prepared in laboratory. 21 cassava and 5 arrowroot commercial samples were purchased in local stores. Raman assays were performed in the range of 400 to 2300 cm−1. Principal component analysis with K-means clustering was used to identify the adulteration of these products. It was possible to observe the separation of three different groups in the data, these groups labelled group 1, 2 and 3 were correspondent to cassava-like samples, mixed samples, and arrowroot-like samples, respectively. Despite the visual analysis related to sensory characteristics and the visual analysis of each Raman spectrum of cassava and arrowroot not being able to differentiate these foodstuffs, the chemometric approaches with the Raman specters data were able to identify which samples were pure arrowroot, pure cassava and which were mixed products. The proposed approach showed to be an effective tool in the investigation of fraud for arrowroot and cassava.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73801675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-11DOI: 10.3390/polysaccharides2030042
Sumudu R. Perera, A. Sokaribo, A. White
Polysaccharides are often the most abundant antigens found on the extracellular surfaces of bacterial cells. These polysaccharides play key roles in interactions with the outside world, and for many bacterial pathogens, they represent what is presented to the human immune system. As a result, many vaccines have been or currently are being developed against carbohydrate antigens. In this review, we explore the diversity of capsular polysaccharides (CPS) in Salmonella and other selected bacterial species and explain the classification and function of CPS as vaccine antigens. Despite many vaccines being developed using carbohydrate antigens, the low immunogenicity and the diversity of infecting strains and serovars present an antigen formulation challenge to manufacturers. Vaccines tend to focus on common serovars or have changing formulations over time, reflecting the trends in human infection, which can be costly and time-consuming. We summarize the approaches to generate carbohydrate-based vaccines for Salmonella, describe vaccines that are in development and emphasize the need for an effective vaccine against non-typhoidal Salmonella strains.
{"title":"Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella","authors":"Sumudu R. Perera, A. Sokaribo, A. White","doi":"10.3390/polysaccharides2030042","DOIUrl":"https://doi.org/10.3390/polysaccharides2030042","url":null,"abstract":"Polysaccharides are often the most abundant antigens found on the extracellular surfaces of bacterial cells. These polysaccharides play key roles in interactions with the outside world, and for many bacterial pathogens, they represent what is presented to the human immune system. As a result, many vaccines have been or currently are being developed against carbohydrate antigens. In this review, we explore the diversity of capsular polysaccharides (CPS) in Salmonella and other selected bacterial species and explain the classification and function of CPS as vaccine antigens. Despite many vaccines being developed using carbohydrate antigens, the low immunogenicity and the diversity of infecting strains and serovars present an antigen formulation challenge to manufacturers. Vaccines tend to focus on common serovars or have changing formulations over time, reflecting the trends in human infection, which can be costly and time-consuming. We summarize the approaches to generate carbohydrate-based vaccines for Salmonella, describe vaccines that are in development and emphasize the need for an effective vaccine against non-typhoidal Salmonella strains.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87469694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-03DOI: 10.3390/polysaccharides2030041
Jeovan A. Araujo, Y. J. Cortese, Marija Mojicevic, Margaret Brennan Fournet, Yuanyuan Chen
Calcium chloride (CaCl2) has been widely used to maintain the quality of fresh-cut fruits and vegetables because it stabilizes and strengthens the membrane system against fungal attacks. It is mainly applied via spray coating and dip coating techniques. This study explored a method of incorporating calcium chloride extracted from eggshells in a packaging material, thermoplastic starch (TPS), via a hot-melt extrusion process. The composites were characterized by FTIR, DSC, SEM-EDX and tensile testing. FTIR confirmed the chemical reactions between CaCl2 and TPS. DSC results showed a significant decrease in the heat of fusion by adding 20 wt% of CaCl2 content in TPS, indicating a drop in the degree of crystallinity. The Young’s modulus of TPS was not significantly affected by the incorporation of 10 wt% CaCl2 (P = 0.968), but reduced notably with the addition of 20 wt% CaCl2 (P = 0.05), indicating the plasticizer effect of the CaCl2. Physiochemical analysis of fresh-cut apple slices was assessed. Samples placed on the surface of the TPS/CaCl2 composites displayed less pH reduction, reduced antioxidant activity, more weight loss and increased reducing sugar compared to the samples placed on the surface of virgin TPS films. CaCl2 released from the TPS/CaCl2 films was measured and their antimicrobial activity was confirmed by bacterial inhibitory growth assessment. Fungal growth was observed on apple slices placed on virgin TPS film by day 21 while apple slices placed on TPS/CaCl2 20 wt% composites did not support any fungal growth for 28 days. In summary, TPS and eggshell-extracted CaCl2 showed the ability to maintain the quality of fresh-cut apples, and TPS/CaCl2 10 wt% composite could be a good option as a packaging material for fresh-cut fruits due to active antimicrobial activity and maintained Young’s modulus.
{"title":"Composite Films of Thermoplastic Starch and CaCl2 Extracted from Eggshells for Extending Food Shelf-Life","authors":"Jeovan A. Araujo, Y. J. Cortese, Marija Mojicevic, Margaret Brennan Fournet, Yuanyuan Chen","doi":"10.3390/polysaccharides2030041","DOIUrl":"https://doi.org/10.3390/polysaccharides2030041","url":null,"abstract":"Calcium chloride (CaCl2) has been widely used to maintain the quality of fresh-cut fruits and vegetables because it stabilizes and strengthens the membrane system against fungal attacks. It is mainly applied via spray coating and dip coating techniques. This study explored a method of incorporating calcium chloride extracted from eggshells in a packaging material, thermoplastic starch (TPS), via a hot-melt extrusion process. The composites were characterized by FTIR, DSC, SEM-EDX and tensile testing. FTIR confirmed the chemical reactions between CaCl2 and TPS. DSC results showed a significant decrease in the heat of fusion by adding 20 wt% of CaCl2 content in TPS, indicating a drop in the degree of crystallinity. The Young’s modulus of TPS was not significantly affected by the incorporation of 10 wt% CaCl2 (P = 0.968), but reduced notably with the addition of 20 wt% CaCl2 (P = 0.05), indicating the plasticizer effect of the CaCl2. Physiochemical analysis of fresh-cut apple slices was assessed. Samples placed on the surface of the TPS/CaCl2 composites displayed less pH reduction, reduced antioxidant activity, more weight loss and increased reducing sugar compared to the samples placed on the surface of virgin TPS films. CaCl2 released from the TPS/CaCl2 films was measured and their antimicrobial activity was confirmed by bacterial inhibitory growth assessment. Fungal growth was observed on apple slices placed on virgin TPS film by day 21 while apple slices placed on TPS/CaCl2 20 wt% composites did not support any fungal growth for 28 days. In summary, TPS and eggshell-extracted CaCl2 showed the ability to maintain the quality of fresh-cut apples, and TPS/CaCl2 10 wt% composite could be a good option as a packaging material for fresh-cut fruits due to active antimicrobial activity and maintained Young’s modulus.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75325725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.3390/polysaccharides2030037
A. G. Souza, Rafaela Reis Ferreira, Elisa Silva Freire Aguilar, Leonardo Zanata, D. Rosa
This work aimed to prepare nanocellulose-based Pickering emulsions using cinnamon essential oil. Different formulations were investigated by varying the preparation time, homogenization speed, oil and nanocellulose concentration, and morphology. The emulsions were first characterized by droplet size, morphologies, and storage stability. The Design of Experiments (DoE) was used to evaluate the parameter’s effects on the emulsions’ stability, and the emulsions with optimum particle size and stability were evaluated by antimicrobial activity. The more stable emulsions required higher energy in the system to obtain efficient emulsification. The cellulose nanocrystal (CNC) emulsions showed a 30% oil volume as a constant to obtain a low creaming index (34.4% and 42.8%) and zeta potential values around −29 mV, indicating an electrostatic stabilization. The cellulose nanofiber (CNF) emulsions showed 100% stability after a month using a 20% oil volume as a constant and Zeta potential values around −15 mV, indicating a steric stabilization. CNF-emulsions’ inhibition halos for Bacilus subtilis were 30.1 ± 3.7% smaller than those found in CNC-emulsions (65 ± 2.9 mm), while Pseudomonasaeruginosas almost do not present differences in the inhibition halos. These results suggest that the nanocellulose morphology may promote a regulation on the EO migration to the medium, as well that this migration ratio does not affect the bacteria.
本研究以肉桂精油为原料制备纳米纤维素皮克林乳液。通过改变制备时间、均质速度、油和纳米纤维素浓度以及形貌来考察不同的配方。乳剂首先通过液滴大小、形态和储存稳定性进行表征。采用实验设计法(Design of Experiments, DoE)评价了各参数对乳剂稳定性的影响，并通过抑菌活性评价了最佳粒径和稳定性乳剂。越稳定的乳剂需要较高的系统能量才能获得有效的乳化。当油量为30%时，纤维素纳米晶(CNC)乳剂的乳化指数较低(34.4%和42.8%)，zeta电位值在−29 mV左右，具有静电稳定性。以20%的油体积为常数，一个月后，纤维素纳米纤维(CNF)乳液的稳定性为100%，Zeta电位值约为- 15 mV，表明其具有空间稳定性。cnf乳剂对枯草芽孢杆菌的抑制晕圈比cnc乳剂(65±2.9 mm)小30.1±3.7%，而铜绿假单胞菌的抑制晕圈几乎没有差异。这些结果表明，纳米纤维素的形态可能促进了EO向培养基的迁移，并且这种迁移比例不影响细菌。
{"title":"Cinnamon Essential Oil Nanocellulose-Based Pickering Emulsions: Processing Parameters Effect on Their Formation, Stabilization, and Antimicrobial Activity","authors":"A. G. Souza, Rafaela Reis Ferreira, Elisa Silva Freire Aguilar, Leonardo Zanata, D. Rosa","doi":"10.3390/polysaccharides2030037","DOIUrl":"https://doi.org/10.3390/polysaccharides2030037","url":null,"abstract":"This work aimed to prepare nanocellulose-based Pickering emulsions using cinnamon essential oil. Different formulations were investigated by varying the preparation time, homogenization speed, oil and nanocellulose concentration, and morphology. The emulsions were first characterized by droplet size, morphologies, and storage stability. The Design of Experiments (DoE) was used to evaluate the parameter’s effects on the emulsions’ stability, and the emulsions with optimum particle size and stability were evaluated by antimicrobial activity. The more stable emulsions required higher energy in the system to obtain efficient emulsification. The cellulose nanocrystal (CNC) emulsions showed a 30% oil volume as a constant to obtain a low creaming index (34.4% and 42.8%) and zeta potential values around −29 mV, indicating an electrostatic stabilization. The cellulose nanofiber (CNF) emulsions showed 100% stability after a month using a 20% oil volume as a constant and Zeta potential values around −15 mV, indicating a steric stabilization. CNF-emulsions’ inhibition halos for Bacilus subtilis were 30.1 ± 3.7% smaller than those found in CNC-emulsions (65 ± 2.9 mm), while Pseudomonasaeruginosas almost do not present differences in the inhibition halos. These results suggest that the nanocellulose morphology may promote a regulation on the EO migration to the medium, as well that this migration ratio does not affect the bacteria.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80686298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-10DOI: 10.3390/polysaccharides2030040
T. V. D. Oliveira, P. V. Freitas, Cicero C. Pola, L. Terra, J. O. Silva, A. T. Badaró, Nelson S. Junior, Marciano M Oliveira, R. R. Silva, N. Soares
On behalf of a circular economy, regular plastics have been replaced by biodegradable packagings. Besides, active films have been applied to improve the shelf-life and quality of foods. In this work, blends were developed using starch as a low-cost natural polymer, mixed with poly(vinyl alcohol) due to its physical-chemical and biodegradable properties. Moreover, maleic anhydride (MaAh), cellulose-nanocrystal (CN), and nisin-z (N-Z) were added, respectively, as a compatibilizer, a mechanical-reinforce, and antimicrobial agents. The thermal stability of the films was analyzed, which blends’ melting temperature occurred around 200–207 °C, and it was influenced by CN, N-Z, and MaAh amounts. N-Z and MaAh acted against S. aureus and P. aeruginosa by compound diffusion (inhibition-halo around 1.85 and 2.18 cm); while S. Choleraesuis and E. coli were inhibited by contact. Therefore, these blends presented the potential to be used as active biodegradable packaging in the food industry.
{"title":"The Influence of Intermolecular Interactions between Maleic Anhydride, Cellulose Nanocrystal, and Nisin-Z on the Structural, Thermal, and Antimicrobial Properties of Starch-PVA Plasticized Matrix","authors":"T. V. D. Oliveira, P. V. Freitas, Cicero C. Pola, L. Terra, J. O. Silva, A. T. Badaró, Nelson S. Junior, Marciano M Oliveira, R. R. Silva, N. Soares","doi":"10.3390/polysaccharides2030040","DOIUrl":"https://doi.org/10.3390/polysaccharides2030040","url":null,"abstract":"On behalf of a circular economy, regular plastics have been replaced by biodegradable packagings. Besides, active films have been applied to improve the shelf-life and quality of foods. In this work, blends were developed using starch as a low-cost natural polymer, mixed with poly(vinyl alcohol) due to its physical-chemical and biodegradable properties. Moreover, maleic anhydride (MaAh), cellulose-nanocrystal (CN), and nisin-z (N-Z) were added, respectively, as a compatibilizer, a mechanical-reinforce, and antimicrobial agents. The thermal stability of the films was analyzed, which blends’ melting temperature occurred around 200–207 °C, and it was influenced by CN, N-Z, and MaAh amounts. N-Z and MaAh acted against S. aureus and P. aeruginosa by compound diffusion (inhibition-halo around 1.85 and 2.18 cm); while S. Choleraesuis and E. coli were inhibited by contact. Therefore, these blends presented the potential to be used as active biodegradable packaging in the food industry.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"71 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89161656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.3390/polysaccharides2030039
Mirella Romanelli Vicente Bertolo, Rafael Leme, Virginia da Conceição Amaro Martins, A. M. de Guzzi Plepis, S. Bogusz Junior
In this study, the effects of an agro-industrial residue with active properties, pomegranate peel extract (PPE), were evaluated on the rheological properties of potential coatings based on chitosan (C) and gelatin (G). For this, rheological properties of the polymeric solutions were investigated in relation to PPE concentration (2 or 4 mg PPE g−1 solution), and to its incorporation order into the system (in C or in CG mixture). All solutions were more viscous than elastic (G″ > G′), and the change in PPE concentration had a greater influence accentuating the viscous character of the samples in which PPE was added to the CG mixture (CGPPE2 and CGPPE4). PPE addition to the CG mixture increased the angular frequency at the moduli crossover, indicating the formation of a more resistant polymeric network. This tendency was also observed in flow results, in which PPE addition decreased the pseudoplastic behavior of the solutions, due to a greater cross-linking between the polymers and the phenolic compounds. In general, all the studied solutions showed viscosities suitable for the proposed application, and it was possible to state the importance of standardizing the addition order of the components during the preparation of a coating.
在本研究中，研究了具有活性的农业工业残留物石榴皮提取物(PPE)对壳聚糖(C)和明胶(G)涂料的流变性能的影响。为此，研究了PPE浓度(2或4 mg PPE G−1溶液)及其加入顺序(在C或CG混合物中)与聚合物溶液的流变性能的关系。所有溶液的黏性都大于弹性(G″> G’)，PPE浓度的变化对加入PPE的CG混合物(CGPPE2和CGPPE4)样品的黏性影响更大。在CG混合物中加入PPE增加了模交叉处的角频率，表明形成了更耐腐蚀的聚合物网络。在流动结果中也观察到这种趋势，PPE的加入降低了溶液的假塑性行为，因为聚合物和酚类化合物之间的交联更大。总的来说，所有研究的溶液都显示出适合提议应用的粘度，并且有可能说明在涂层制备过程中标准化组分添加顺序的重要性。
{"title":"Rheological Characterization of the Influence of Pomegranate Peel Extract Addition and Concentration in Chitosan and Gelatin Coatings","authors":"Mirella Romanelli Vicente Bertolo, Rafael Leme, Virginia da Conceição Amaro Martins, A. M. de Guzzi Plepis, S. Bogusz Junior","doi":"10.3390/polysaccharides2030039","DOIUrl":"https://doi.org/10.3390/polysaccharides2030039","url":null,"abstract":"In this study, the effects of an agro-industrial residue with active properties, pomegranate peel extract (PPE), were evaluated on the rheological properties of potential coatings based on chitosan (C) and gelatin (G). For this, rheological properties of the polymeric solutions were investigated in relation to PPE concentration (2 or 4 mg PPE g−1 solution), and to its incorporation order into the system (in C or in CG mixture). All solutions were more viscous than elastic (G″ > G′), and the change in PPE concentration had a greater influence accentuating the viscous character of the samples in which PPE was added to the CG mixture (CGPPE2 and CGPPE4). PPE addition to the CG mixture increased the angular frequency at the moduli crossover, indicating the formation of a more resistant polymeric network. This tendency was also observed in flow results, in which PPE addition decreased the pseudoplastic behavior of the solutions, due to a greater cross-linking between the polymers and the phenolic compounds. In general, all the studied solutions showed viscosities suitable for the proposed application, and it was possible to state the importance of standardizing the addition order of the components during the preparation of a coating.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89307884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.3390/polysaccharides2030038
Y. De Anda-Flores, E. Carvajal‐Millan, A. Campa-Mada, J. Lizardi‐Mendoza, A. Rascón-Chu, J. Tánori-Córdova, A. Martínez-López
Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.
{"title":"Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems","authors":"Y. De Anda-Flores, E. Carvajal‐Millan, A. Campa-Mada, J. Lizardi‐Mendoza, A. Rascón-Chu, J. Tánori-Córdova, A. Martínez-López","doi":"10.3390/polysaccharides2030038","DOIUrl":"https://doi.org/10.3390/polysaccharides2030038","url":null,"abstract":"Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75675380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-12DOI: 10.3390/POLYSACCHARIDES2030036
C. Leyva‐Porras, M. Román-Aguirre, Pedro Cruz-Alcantar, J. Pérez-Urizar, M. Z. Saavedra-Leos
Oxidation is the main problem in preserving food products during storage. A relatively novel strategy is the use of antioxidant-enriched edible films. Antioxidants hinder reactive oxygen species, which mainly affect fats and proteins in food. At present, these films have been improved by the addition of micro- and nanoliposomes coated with carbohydrate polymers, which are not hazardous for human health and can be ingested without risk. The liposomes are loaded with different antioxidants, and their effects are observed as a longer storage time of the food product. The synergy of these methodologies and advances can lead to the displacement of the protective packaging used currently, which would result in food products with functional properties added by the films, an increase in shelf life, and an improvement to the environment by reducing the amount of waste.
{"title":"Application of Antioxidants as an Alternative Improving of Shelf Life in Foods","authors":"C. Leyva‐Porras, M. Román-Aguirre, Pedro Cruz-Alcantar, J. Pérez-Urizar, M. Z. Saavedra-Leos","doi":"10.3390/POLYSACCHARIDES2030036","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2030036","url":null,"abstract":"Oxidation is the main problem in preserving food products during storage. A relatively novel strategy is the use of antioxidant-enriched edible films. Antioxidants hinder reactive oxygen species, which mainly affect fats and proteins in food. At present, these films have been improved by the addition of micro- and nanoliposomes coated with carbohydrate polymers, which are not hazardous for human health and can be ingested without risk. The liposomes are loaded with different antioxidants, and their effects are observed as a longer storage time of the food product. The synergy of these methodologies and advances can lead to the displacement of the protective packaging used currently, which would result in food products with functional properties added by the films, an increase in shelf life, and an improvement to the environment by reducing the amount of waste.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81711369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-06DOI: 10.3390/POLYSACCHARIDES2030035
W. H. Ferreira, C. T. Andrade
Development of biodegradable materials for packaging is an issue of the utmost importance. These materials are an alternative to petroleum-based polymers, which contribute to environment pollution after disposal. In this work, graphene oxide (GO) and glucose-reduced graphene oxide (rGO-g) were incorporated to thermoplastic starch (TPS) by melt extrusion. The TPS/GO and TPS/rGO-g composites had their physical properties and biodegradability compared. X-ray diffraction (XRD) showed that the type of graphene used led to different dispersion levels of graphene sheets, and to changes in the crystalline structure of TPS. Tensile tests carried out for the compression-molded composites indicated that TPS/rGO-g composites presented better mechanical performance. The Young’s modulus (E) increased from E = (28.6 ± 2.7) MPa, for TPS, to E = (110.6 ± 9.5) MPa and to (144.2 ± 11.2) MPa for TPS with rGO-g incorporated at 1.0 and 2.0 mass% content, respectively. The acid groups from graphene derivatives promoted glycosidic bond breakage of starch molecules and improved biodegradation of the composites. GO is well-dispersed in the TPS matrix, which contributes to biodegradation. For TPS/rGO-g materials, biodegradation was influenced by rGO-g dispersion level.
{"title":"Physical and Biodegradation Properties of Graphene Derivatives/Thermoplastic Starch Composites","authors":"W. H. Ferreira, C. T. Andrade","doi":"10.3390/POLYSACCHARIDES2030035","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2030035","url":null,"abstract":"Development of biodegradable materials for packaging is an issue of the utmost importance. These materials are an alternative to petroleum-based polymers, which contribute to environment pollution after disposal. In this work, graphene oxide (GO) and glucose-reduced graphene oxide (rGO-g) were incorporated to thermoplastic starch (TPS) by melt extrusion. The TPS/GO and TPS/rGO-g composites had their physical properties and biodegradability compared. X-ray diffraction (XRD) showed that the type of graphene used led to different dispersion levels of graphene sheets, and to changes in the crystalline structure of TPS. Tensile tests carried out for the compression-molded composites indicated that TPS/rGO-g composites presented better mechanical performance. The Young’s modulus (E) increased from E = (28.6 ± 2.7) MPa, for TPS, to E = (110.6 ± 9.5) MPa and to (144.2 ± 11.2) MPa for TPS with rGO-g incorporated at 1.0 and 2.0 mass% content, respectively. The acid groups from graphene derivatives promoted glycosidic bond breakage of starch molecules and improved biodegradation of the composites. GO is well-dispersed in the TPS matrix, which contributes to biodegradation. For TPS/rGO-g materials, biodegradation was influenced by rGO-g dispersion level.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89957853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-02DOI: 10.3390/POLYSACCHARIDES2030034
M. Fernandes, A. P. Souto, F. Dourado, M. Gama
Several studies report the potential of bacterial cellulose (BC) in the fashion and leather industries. This work aimed at the development of BC-based composites containing emulsified acrylated epoxidized soybean oil (AESO) that are polymerized with the redox initiator system hydrogen peroxide (H2O2) and L-ascorbic acid and ferrous sulfate as a catalyst. BC was fermented under static culture. The polymerization of the emulsified organic droplets was tested before and after their incorporation into BC by exhaustion. The composites were then finished with an antimicrobial agent (benzalkonium chloride) and dyed. The obtained composites were characterized in terms of wettability, water vapor permeability (WVP), mechanical, thermal and antimicrobial properties. When AESO emulsion was polymerized prior to the exhaustion process, the obtained composites showed higher WVP, tensile strength and thermal stability. Meanwhile, post-exhaustion polymerized AESO conferred the composite higher hydrophobicity and elongation. The composites finished with the antimicrobial agent showed activity against S. aureus. Finally, intense colors were obtained more uniformly when they were incorporated simultaneously with the emulsified AESO with all the dyes tested.
{"title":"Application of Bacterial Cellulose in the Textile and Shoe Industry: Development of Biocomposites","authors":"M. Fernandes, A. P. Souto, F. Dourado, M. Gama","doi":"10.3390/POLYSACCHARIDES2030034","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2030034","url":null,"abstract":"Several studies report the potential of bacterial cellulose (BC) in the fashion and leather industries. This work aimed at the development of BC-based composites containing emulsified acrylated epoxidized soybean oil (AESO) that are polymerized with the redox initiator system hydrogen peroxide (H2O2) and L-ascorbic acid and ferrous sulfate as a catalyst. BC was fermented under static culture. The polymerization of the emulsified organic droplets was tested before and after their incorporation into BC by exhaustion. The composites were then finished with an antimicrobial agent (benzalkonium chloride) and dyed. The obtained composites were characterized in terms of wettability, water vapor permeability (WVP), mechanical, thermal and antimicrobial properties. When AESO emulsion was polymerized prior to the exhaustion process, the obtained composites showed higher WVP, tensile strength and thermal stability. Meanwhile, post-exhaustion polymerized AESO conferred the composite higher hydrophobicity and elongation. The composites finished with the antimicrobial agent showed activity against S. aureus. Finally, intense colors were obtained more uniformly when they were incorporated simultaneously with the emulsified AESO with all the dyes tested.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84916381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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