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Pride in gastroenterology and hepatology 以肠胃病学和肝病学为荣
IF 65.1 1区 医学 Q1 Medicine Pub Date : 2024-05-31 DOI: 10.1038/s41575-024-00939-8
For Pride Month, we celebrate the LGBTQ+ community and take stock of the challenges they continue to experience. Gastroenterologists and hepatologists can and should advocate, improve inclusion and be effective allies for our LGBTQ+ colleagues and patients.
在自豪月,我们庆祝 LGBTQ+ 群体,并总结他们继续经历的挑战。肠胃病学家和肝病学家可以而且应该为我们的 LGBTQ+ 同事和患者进行宣传、提高包容性并成为他们的有效盟友。
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引用次数: 0
Mechanisms of metastatic colorectal cancer 转移性结直肠癌的发病机制。
IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-28 DOI: 10.1038/s41575-024-00934-z
Adrià Cañellas-Socias, Elena Sancho, Eduard Batlle
Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily owing to limited therapeutic options and a poor prognosis. This Review addresses the emerging focus on metastatic CRC (mCRC), which has historically been under-studied compared with primary CRC despite its lethality. We delve into two crucial aspects: the molecular and cellular determinants facilitating CRC metastasis and the principles guiding the evolution of metastatic disease. Initially, we examine the genetic alterations integral to CRC metastasis, connecting them to clinically marked characteristics of advanced CRC. Subsequently, we scrutinize the role of cellular heterogeneity and plasticity in metastatic spread and therapy resistance. Finally, we explore how the tumour microenvironment influences metastatic disease, emphasizing the effect of stromal gene programmes and the immune context. The ongoing research in these fields holds immense importance, as its future implications are projected to revolutionize the treatment of patients with mCRC, hopefully offering a promising outlook for their survival. Metastatic colorectal cancer (mCRC) has a poor prognosis, and therapeutic options are limited. This Review provides a comprehensive overview of the genetic and molecular underpinnings of mCRC, discussing the therapeutic potential arising from this knowledge.
尽管对结直肠癌(CRC)进行了广泛的研究,对其认识也有所提高,但其转移形式仍然是一个巨大的挑战,主要原因是治疗方案有限且预后较差。与原发性 CRC 相比,尽管转移性 CRC 具有致命性,但对它的研究历来不足。我们将深入探讨两个关键方面:促进 CRC 转移的分子和细胞决定因素以及指导转移性疾病演变的原则。首先,我们研究了 CRC 转移不可或缺的基因改变,并将其与晚期 CRC 的临床特征联系起来。随后,我们仔细研究了细胞异质性和可塑性在转移扩散和耐药性中的作用。最后,我们探讨了肿瘤微环境如何影响转移性疾病,强调了基质基因计划和免疫环境的影响。这些领域正在进行的研究具有极其重要的意义,因为其未来的影响预计将彻底改变 mCRC 患者的治疗方法,有望为他们的生存带来光明前景。
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引用次数: 0
Positive phase III trials for ileal bile acid transporter inhibitors 回肠胆汁酸转运抑制剂的 III 期试验结果呈阳性。
IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-23 DOI: 10.1038/s41575-024-00945-w
Katrina Ray
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引用次数: 0
Sex and ethnic disparities persist in hepatitis B management 在乙型肝炎管理方面,性别和种族差异依然存在。
IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-22 DOI: 10.1038/s41575-024-00946-9
Katrina Ray
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引用次数: 0
A single-cell multiomics profile of Fontan-associated liver disease 丰坦相关肝病的单细胞多组学图谱
IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-21 DOI: 10.1038/s41575-024-00944-x
Katrina Ray
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引用次数: 0
Microbiota and colorectal cancer — controlling for confounders challenges associations 微生物群与结直肠癌--控制混杂因素挑战关联性
IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-21 DOI: 10.1038/s41575-024-00947-8
Katrina Ray
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引用次数: 0
Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus 肛交的快感和问题以及结肠、直肠和肛门疾病。
IF 65.1 1区 医学 Q1 Medicine Pub Date : 2024-05-19 DOI: 10.1038/s41575-024-00932-1
Daniel R. Dickstein, Collin R. Edwards, Catherine R. Rowan, Bella Avanessian, Barbara M. Chubak, Christopher W. Wheldon, Priya K. Simoes, Michael H. Buckstein, Laurie A. Keefer, Joshua D. Safer, Keith Sigel, Karyn A. Goodman, B. R. Simon Rosser, Stephen E. Goldstone, Serre-Yu Wong, Deborah C. Marshall
The ability to experience pleasurable sexual activity is important for human health. Receptive anal intercourse (RAI) is a common, though frequently stigmatized, pleasurable sexual activity. Little is known about how diseases of the colon, rectum, and anus and their treatments affect RAI. Engaging in RAI with gastrointestinal disease can be difficult due to the unpredictability of symptoms and treatment-related toxic effects. Patients might experience sphincter hypertonicity, gastrointestinal symptom-specific anxiety, altered pelvic blood flow from structural disorders, decreased sensation from cancer-directed therapies or body image issues from stoma creation. These can result in problematic RAI — encompassing anodyspareunia (painful RAI), arousal dysfunction, orgasm dysfunction and decreased sexual desire. Therapeutic strategies for problematic RAI in patients living with gastrointestinal diseases and/or treatment-related dysfunction include pelvic floor muscle strengthening and stretching, psychological interventions, and restorative devices. Providing health-care professionals with a framework to discuss pleasurable RAI and diagnose problematic RAI can help improve patient outcomes. Normalizing RAI, affirming pleasure from RAI and acknowledging that the gastrointestinal system is involved in sexual pleasure, sexual function and sexual health will help transform the scientific paradigm of sexual health to one that is more just and equitable. Receptive anal intercourse (RAI) is an important consideration in gastrointestinal disorders and cancers. This Review discusses the anorectum as a sexual organ, providing an overview of pleasurable and problematic RAI and how gastrointestinal disease itself and associated treatments (such as surgery) can affect RAI. Strategies to manage problematic RAI to improve sexual health are also described.
体验愉悦性活动的能力对人类健康非常重要。接受性肛交(RAI)是一种常见的愉悦性活动,尽管经常被人鄙视。人们对结肠、直肠和肛门疾病及其治疗对肛交的影响知之甚少。由于症状和治疗相关毒性反应的不可预测性,患有胃肠道疾病的患者很难进行 RAI。患者可能会出现括约肌张力过高、胃肠道症状特有的焦虑、结构性疾病导致的骨盆血流改变、癌症导向疗法导致的感觉减退或造口术导致的身体形象问题。这些都可能导致 RAI 问题--包括无性交痛(RAI 疼痛)、性唤起功能障碍、性高潮功能障碍和性欲减退。针对患有胃肠道疾病和/或与治疗相关的功能障碍的患者的 RAI 问题,治疗策略包括骨盆底肌肉强化和拉伸、心理干预和恢复装置。为医护人员提供一个讨论愉悦性 RAI 和诊断有问题 RAI 的框架,有助于改善患者的治疗效果。将 RAI 正常化、肯定 RAI 带来的快感并承认胃肠道系统与性快感、性功能和性健康有关,将有助于将性健康的科学范式转变为更加公正和公平的范式。
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引用次数: 0
Telemedicine for hepatitis C virus treatment in opioid treatment programmes 阿片类药物治疗方案中的丙型肝炎病毒治疗远程医疗
IF 65.1 1区 医学 Q1 Medicine Pub Date : 2024-05-15 DOI: 10.1038/s41575-024-00942-z
Jordan Hindson
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引用次数: 0
Development of MKK4 inhibitors for liver regeneration 开发用于肝脏再生的 MKK4 抑制剂
IF 65.1 1区 医学 Q1 Medicine Pub Date : 2024-05-15 DOI: 10.1038/s41575-024-00940-1
Jordan Hindson
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引用次数: 0
Rhythmicity of infant microbiota and dietary effects 婴儿微生物群的节律性和饮食影响
IF 65.1 1区 医学 Q1 Medicine Pub Date : 2024-05-14 DOI: 10.1038/s41575-024-00943-y
Jordan Hindson
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引用次数: 0
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