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Multivariate maternal effects across the internalizing-externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study. 儿童期内化-外化光谱的多变量母亲效应:来自挪威母亲、父亲和儿童队列研究的结果。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-13 DOI: 10.1111/jcpp.70111
Espen Moen Eilertsen,Nikolai Haahjem Eftedal,Rosa Cheesman,Ziada Ayorech,Joakim Coleman Ebeltoft,Hans Fredrik Sunde,Anneli Desiré Tandberg,Fartein Ask Torvik,Eivind Ystrom
BACKGROUNDFrom a functionalist perspective, parenting behaviors have adaptive functions and are partly expressions of genetic variation. Maternal genes that have effects on children are often referred to as indirect maternal genetic effects. Indirect genetic effects provide a means for measuring the role of parenting without the need for specifying the relevant parental behaviors. We studied indirect maternal genetic effects to address both the importance and commonality of parenting across the internalizing-externalizing spectrum of behavior problems in childhood. We further addressed how indirect genetic effects impact our understanding of direct genetic effects if not accounted for.METHODSUtilizing data from the Norwegian Mother, Father, and Child Cohort Study (MoBa), our analyses involved 42,423 children and their mothers. Both pedigree and genotype data were used to infer genetic relationships. We applied multivariate latent variable models to distinguish indirect maternal genetic effects and direct offspring genetic effects on seven measures of internalizing-externalizing behaviors.RESULTSOur findings indicate significant maternal genetic influences, explaining 7%-18% of the variance across internalizing-externalizing behaviors. A general maternal effect common across behaviors could adequately account for most of the variability. The analyses further indicate that direct child genetic effects appear smaller and more complex when indirect maternal genetic effects are modeled simultaneously.CONCLUSIONSBy summarizing the effects of parenting with indirect maternal genetic effects, we show a substantial contribution of parents with respect to internalizing-externalizing behaviors in childhood. Although parenting is multifaceted, the effects of parenting are general and can succinctly be described as a single common dimension. Further, our study demonstrates that direct genetic effects appear smaller and more complex when maternal genetic effects are accounted for, highlighting the confounding potential of parental effects in understanding the role of genetic differences in child psychopathology.
从功能主义的角度来看,养育行为具有适应功能,部分是遗传变异的表现。对儿童产生影响的母系基因通常被称为间接母系遗传效应。间接遗传效应提供了一种方法来衡量父母的作用,而不需要具体说明相关的父母行为。我们研究了间接的母亲遗传效应,以解决在童年行为问题的内在化-外在化谱系中养育的重要性和共性。我们进一步讨论了间接遗传效应如何影响我们对直接遗传效应的理解,如果没有解释。方法利用挪威母亲、父亲和儿童队列研究(MoBa)的数据,我们的分析涉及42,423名儿童及其母亲。家系和基因型数据被用来推断遗传关系。我们应用多变量潜变量模型来区分内化-外化行为的七种测量指标的间接母系遗传效应和直接子代遗传效应。结果母亲遗传因素对内化-外化行为的影响显著,解释了7%-18%的内化-外化行为差异。在行为中普遍存在的母性效应可以充分解释大部分的可变性。分析进一步表明,当同时模拟间接的母亲遗传效应时,直接的儿童遗传效应显得更小、更复杂。结论通过总结父母的间接遗传效应,我们发现父母对儿童的内化-外化行为有很大的影响。虽然养育子女是多方面的,但养育子女的影响是普遍的,可以简洁地描述为一个共同的维度。此外,我们的研究表明,当考虑到母亲的遗传效应时,直接遗传效应显得更小、更复杂,这突出了父母效应在理解遗传差异在儿童精神病理学中的作用方面的混淆潜力。
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引用次数: 0
Annual Research Review: The role of caregiver sensitivity in children's developmental outcomes - an umbrella review. 年度研究回顾:照顾者敏感性在儿童发展结果中的作用-总括性回顾。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-07 DOI: 10.1111/jcpp.70087
Marissa D Nivison, Pasco Fearon, Jennifer M Jenkins, Sheri Madigan

Caregiver sensitivity is the extent to which a caregiver notices a child's signal, interprets it correctly, and responds quickly and appropriately. Although originally introduced to developmental science as the key antecedent of attachment security, decades since its conception, hundreds of studies have been conducted examining the predictive significance of caregiver sensitivity to a broad range of developmental outcomes. The literature on caregiver sensitivity and related constructs (e.g., warmth, responsivity, negative parenting) has grown exponentially and is now the focus of several meta-analyses. We conducted an umbrella review - a systematic review of reviews - to examine the extent to which caregiver sensitivity and related constructs are associated with child attachment, socioemotional, and cognitive outcomes. Searches in EMBASE, PsycINFO, and Medline and yielded 2,157 abstracts. Studies were included if they were a meta-analysis of caregiver sensitivity or a related construct, focused on children's developmental outcomes, were available in English, French, or Spanish, and were published between 2010 and 2024. Conducted and reported in accordance with PRISMA guidelines, 17 meta-analyses were identified. Using the metaumbrella package in R, we conducted quantitative analyses which demonstrated that caregiver sensitivity was moderately associated with attachment security (r = .25, k = 253, n = 37,444), cognition (r = .23, k = 44, n = 6,777), language skills (r = .26, k = 54, n = 11,136), and weakly associated with socioemotional problems (r = -.07, k = 135, n = 33,305). Narrative analysis of other meta-analyses on caregiver warmth, responsivity, positive and negative parenting, and child outcomes also showed associations in the expected direction. Our findings demonstrate the critical importance of caregiver sensitivity on children's socioemotional and cognitive development, supporting caregiver sensitivity as an important target for early childhood prevention and intervention programs.

照顾者的敏感性是照顾者注意到孩子的信号,正确地解释它,并迅速和适当地作出反应的程度。虽然最初是作为依恋安全的关键前提引入发展科学的,但在其概念提出几十年后,已经进行了数百项研究,以检验照顾者敏感性对广泛发展结果的预测意义。关于照顾者敏感性和相关结构(例如,温暖、反应性、消极养育)的文献呈指数级增长,现在是几个元分析的焦点。我们进行了一项总括性的综述——一项综述的系统综述——来研究照顾者敏感性和相关构念与儿童依恋、社会情感和认知结果的关联程度。在EMBASE、PsycINFO和Medline中搜索,得到2157篇摘要。如果研究是对照顾者敏感性的荟萃分析或相关结构,关注儿童的发展结果,以英语、法语或西班牙语提供,并在2010年至2024年之间发表,则纳入研究。根据PRISMA指南进行和报告,确定了17项荟萃分析。使用R中的元伞包,我们进行了定量分析,结果表明照顾者敏感性与依恋安全性有中度相关(R =。25, k = 253, n = 37,444),认知(r =。23, k = 44, n = 6,777),语言技能(r =。26, k = 54, n = 11,136),与社会情绪问题的相关性较弱(r = - 0.07, k = 135, n = 33,305)。对其他关于照顾者温暖度、反应性、积极和消极养育方式与儿童结局的元分析的叙述分析也显示出与预期方向的关联。我们的研究结果表明,照顾者敏感性对儿童的社会情感和认知发展至关重要,支持照顾者敏感性作为儿童早期预防和干预计划的重要目标。
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引用次数: 0
Practitioner Review: Infant mental health meets cell and molecular biology - a look to the future. 从业者评论:婴儿心理健康与细胞和分子生物学——展望未来。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-07 DOI: 10.1111/jcpp.70097
Charles H Zeanah,Megan Hare,Katherine Cowhey,Stacy S Drury
BACKGROUNDA major research effort in the past two decades has begun to illuminate how experience 'gets under the skin' - that is - the cellular and molecular processes that are associated with adversity and resilience.METHODSWe selectively review three areas of this research: epigenetics, especially DNA methylation, telomere length, and inflammatory processes, and consider the implications of this work for better understanding the effects of adversity and pathways of recovery.RESULTSBecause infant mental health practitioners focus on children in the earliest years of life, they are well positioned to favorably alter the developmental trajectories of children experiencing or at risk for maladaptation. In addition to helping us develop more individually effective treatments, we consider other ways in which research advances in cell and molecular biology may be especially important to infant mental health practitioners in the future.CONCLUSIONSBetter understanding these processes will enhance effectiveness and potentially enlarge the scope of our practice.
在过去的二十年里,一项重要的研究工作已经开始阐明经历是如何“深入人心”的——也就是说,与逆境和适应力相关的细胞和分子过程。方法我们选择性地回顾了本研究的三个领域:表观遗传学,特别是DNA甲基化,端粒长度和炎症过程,并考虑这项工作对更好地理解逆境的影响和恢复途径的意义。结果:由于婴幼儿心理健康从业者关注的是生命早期的儿童,因此他们能够很好地改变正在经历或有适应不良风险的儿童的发展轨迹。除了帮助我们开发更个别有效的治疗方法外,我们还考虑了细胞和分子生物学的研究进展在其他方面可能对未来的婴儿心理健康从业人员特别重要。结论更好地了解这些过程将提高有效性,并有可能扩大我们的实践范围。
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引用次数: 0
Gut microbiome as a predictor for positive youth development transition from childhood to early adolescence: a cohort study 肠道微生物组作为从儿童期到青春期早期的积极青年发展过渡的预测因子:一项队列研究
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-06 DOI: 10.1111/jcpp.70109
Yujie Xu, Xiaoyu Wang, Mengxue Chen, Jingyuan Xiong, Guo Cheng
Background The gut microbiome is increasingly implicated in childhood mental health and may influence positive youth development (PYD). This study aims to characterize PYD transition patterns from childhood to adolescence and explore the predictive value of the gut microbiome. Methods This cohort study used two waves of data from the Chinese Adolescent Cohort study, including children aged 8–11 years at Wave 1, from Sichuan, Guizhou, and Chongqing provinces. PYD was assessed at both time points, and latent transition analysis identified changes over the 3‐year follow‐up period. Baseline stool samples were analyzed using 16 s rRNA sequencing. A light gradient boosting machine model was developed to link gut microbiota with PYD transition type in a training set (70%, n = 461), and validated with multinominal logistic analysis within a test set (30%, n = 200). Linear regression models were performed to assess dietary modifications on the gut microbiome. Results Three PYD transition profiles were identified: downgraded (declining to a lower pattern), promoted (advancing to a higher pattern), and stable development type (remaining in the same pattern). Fifteen microbial genera were identified as predictors of PYD transitions, and children with higher abundance of these taxa were more likely to transition to a stable or promoted profile rather than a downgraded profile (odds ratio ranging from 2.03 to 5.45). This predictive model demonstrated excellent performance, with an area under the curve of 0.91 (95% CI: 0.89, 0.93). The microbiome‐PYD transition association was more pronounced in children in earlier stages of puberty. Furthermore, a diet high in fruits, vegetables, and soybeans was positively linked with PYD stable or promoted transition type. Conclusions The gut microbiome presents predictive value in PYD transition from childhood to adolescence. Targeting these microbial taxa may inform future health promotion programs to optimize child development, particularly during the critical pubertal transition.
肠道微生物组越来越多地与儿童心理健康有关,并可能影响积极的青年发展(PYD)。本研究旨在描述PYD从儿童期到青春期的过渡模式,并探索肠道微生物组的预测价值。方法:本队列研究使用了来自中国青少年队列研究的两波数据,包括来自四川、贵州和重庆三省的8-11岁儿童。在两个时间点评估PYD,潜在转变分析确定了3年随访期间的变化。基线粪便样本采用16s rRNA测序进行分析。在训练集(70%,n = 461)中建立了轻梯度增强机模型,将肠道微生物群与PYD过渡类型联系起来,并在测试集(30%,n = 200)中进行多项逻辑分析验证。采用线性回归模型评估饮食改变对肠道微生物组的影响。结果确定了3种PYD过渡类型:降级型(下降到较低模式)、提升型(上升到较高模式)和稳定发展型(保持不变模式)。15个微生物属被确定为PYD过渡的预测因子,这些类群丰度较高的儿童更有可能过渡到稳定或提升的剖面而不是降级的剖面(比值比为2.03 ~ 5.45)。该预测模型表现出优异的性能,曲线下面积为0.91 (95% CI: 0.89, 0.93)。在青春期早期的儿童中,微生物组与PYD的过渡关系更为明显。此外,富含水果、蔬菜和大豆的饮食与PYD稳定或促进过渡型呈正相关。结论肠道微生物组对儿童期到青春期PYD的转变具有预测价值。以这些微生物类群为目标,可以为未来的健康促进计划提供信息,以优化儿童发育,特别是在关键的青春期过渡期间。
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引用次数: 0
Vitamin D supplementation in the first 2 years and autism spectrum traits at 6–8 years – a randomized clinical trial 前两年补充维生素D和6-8岁的自闭症谱系特征——一项随机临床试验
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-05 DOI: 10.1111/jcpp.70110
Samuel Sandboge, Vilja Seppälä, Sakari Lintula, Elisa Holmlund‐Suila, Helena Hauta‐alus, Eero Kajantie, Outi Mäkitie, Sture Andersson, Katri Räikkönen, Kati Heinonen
Background Early life vitamin D levels may be associated with autism spectrum disorder (ASD) and related traits, but causality is unknown. We examine whether higher‐than‐standard vitamin D 3 supplementation during the first 2 years, as well as higher pregnancy and childhood 25‐hydroxyvitamin D (25(OH)D) levels and their trajectories, are associated with lower ASD trait scores at ages 6–8 years in a non‐clinical cohort. Methods This secondary analysis of the double‐blind randomized clinical trial vitamin D intervention in infants (VIDI) comprised 366 Finnish children aged 6–8 years, 177 of whom were randomized to receive 400‐IU and 189 to receive 1,200‐IU daily oral vitamin D 3 supplementation between ages 2 weeks and 2 years. ASD‐related traits were assessed at mean age 7.2 years (SD 0.4) using the parent‐reported Autism Spectrum Screening Questionnaire (ASSQ). Predictor variables were supplementation group, 25(OH)D concentrations measured during pregnancy and at ages 1 and 2 years, as well as 25(OH)D trajectories (high vs. low) derived from these time points. Results None of the predictor variables of interest were associated with the outcome in the full sample. After sex stratification, among boys, 25(OH)D concentrations at 1 and 2 years were inversely associated with ASSQ scores (mean difference −0.2 of normalized SD score (95% CI −0.3 to −0.1, p = .003) and −0.2 (95% CI −0.3 to −0.05, p = .01) per 10 ng/mL 25(OH)D) after adjustment for age, breastfeeding, parental education, maternal depressive symptoms, and season of 25(OH)D assessment as was belonging to the higher 25(OH)D trajectory, −0.45 SD (95% CI −0.79 to −0.10, p = .01). Conclusions We found no indication that higher‐than‐normal vitamin D 3 supplementation between ages 0 and 2 years decreases ASD‐related trait scores at ages 6–8 years. Sex‐stratified analysis suggested an inverse association, among boys, between early life 25(OH)D concentrations and ASD‐related traits, warranting further studies on potential causal direction and sex specificity of associations.
背景:生命早期维生素D水平可能与自闭症谱系障碍(ASD)及其相关特征有关,但因果关系尚不清楚。在一项非临床队列研究中,我们研究了前两年高于标准的维生素d3补充剂,以及妊娠期和儿童期较高的25 -羟基维生素D (25(OH)D)水平及其轨迹,是否与6-8岁时较低的ASD特征评分相关。方法:对婴儿维生素D干预(VIDI)的双盲随机临床试验(双盲随机临床试验)进行二次分析,包括366名6-8岁的芬兰儿童,其中177名随机接受400 IU的每日口服维生素D补充剂,189名随机接受1200 IU的每日口服维生素D补充剂,年龄为2周至2岁。使用父母报告的自闭症谱系筛查问卷(ASSQ)在平均7.2岁(SD 0.4)时评估ASD相关特征。预测变量是补充组,怀孕期间和1岁和2岁时测量的25(OH)D浓度,以及从这些时间点得出的25(OH)D轨迹(高与低)。结果在整个样本中,没有一个相关的预测变量与结果相关。性别分层后,男孩,25 (OH) D的浓度在1和2年ASSQ评分呈负相关(平均差−0.2规范化SD得分(95% CI 0.3−−0.1,p = .003)和−0.2 (95% CI 0.3−−0.05,p = . 01)每10 ng / mL 25 (OH) D)年龄调整后,母乳喂养,父母的教育,母亲抑郁症状,和赛季25 (OH) D的评估是属于高25 (OH) D轨迹,SD−0.45 (95% CI 0.79−−0.10,p = . 01)。结论:我们没有发现任何迹象表明,0 - 2岁儿童补充高于正常水平的维生素d3会降低6-8岁儿童的ASD相关特征评分。性别分层分析表明,在男孩中,生命早期25(OH)D浓度与ASD相关特征呈负相关,这需要进一步研究潜在的因果方向和相关的性别特异性。
{"title":"Vitamin D supplementation in the first 2 years and autism spectrum traits at 6–8 years – a randomized clinical trial","authors":"Samuel Sandboge, Vilja Seppälä, Sakari Lintula, Elisa Holmlund‐Suila, Helena Hauta‐alus, Eero Kajantie, Outi Mäkitie, Sture Andersson, Katri Räikkönen, Kati Heinonen","doi":"10.1111/jcpp.70110","DOIUrl":"https://doi.org/10.1111/jcpp.70110","url":null,"abstract":"Background Early life vitamin D levels may be associated with autism spectrum disorder (ASD) and related traits, but causality is unknown. We examine whether higher‐than‐standard vitamin D <jats:sub>3</jats:sub> supplementation during the first 2 years, as well as higher pregnancy and childhood 25‐hydroxyvitamin D (25(OH)D) levels and their trajectories, are associated with lower ASD trait scores at ages 6–8 years in a non‐clinical cohort. Methods This secondary analysis of the double‐blind randomized clinical trial vitamin D intervention in infants (VIDI) comprised 366 Finnish children aged 6–8 years, 177 of whom were randomized to receive 400‐IU and 189 to receive 1,200‐IU daily oral vitamin D <jats:sub>3</jats:sub> supplementation between ages 2 weeks and 2 years. ASD‐related traits were assessed at mean age 7.2 years (SD 0.4) using the parent‐reported Autism Spectrum Screening Questionnaire (ASSQ). Predictor variables were supplementation group, 25(OH)D concentrations measured during pregnancy and at ages 1 and 2 years, as well as 25(OH)D trajectories (high vs. low) derived from these time points. Results None of the predictor variables of interest were associated with the outcome in the full sample. After sex stratification, among boys, 25(OH)D concentrations at 1 and 2 years were inversely associated with ASSQ scores (mean difference −0.2 of normalized SD score (95% CI −0.3 to −0.1, <jats:italic>p</jats:italic> = .003) and −0.2 (95% CI −0.3 to −0.05, <jats:italic>p</jats:italic> = .01) per 10 ng/mL 25(OH)D) after adjustment for age, breastfeeding, parental education, maternal depressive symptoms, and season of 25(OH)D assessment as was belonging to the higher 25(OH)D trajectory, −0.45 SD (95% CI −0.79 to −0.10, <jats:italic>p</jats:italic> = .01). Conclusions We found no indication that higher‐than‐normal vitamin D <jats:sub>3</jats:sub> supplementation between ages 0 and 2 years decreases ASD‐related trait scores at ages 6–8 years. Sex‐stratified analysis suggested an inverse association, among boys, between early life 25(OH)D concentrations and ASD‐related traits, warranting further studies on potential causal direction and sex specificity of associations.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"80 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The nature and nurture of primary and secondary callous–unemotional traits: evidence from two independent twin samples 主要和次要冷酷无情特征的本质和培养:来自两个独立双胞胎样本的证据
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-05 DOI: 10.1111/jcpp.70107
Rachel C. Tomlinson, Patrizia Pezzoli, Essi Viding, Stephane A. De Brito, Kelly L. Klump, S. Alexandra Burt, Luke W. Hyde
Background Callous–unemotional (CU) traits identify youth with more severe and chronic trajectories of conduct problems. However, the etiology of CU traits may be heterogeneous, undermining the search for effective treatments. The level of co‐occurring anxiety has been used to identify “primary” (lower anxiety) versus “secondary” (higher anxiety) variants of CU traits. The primary variant has been hypothesized to emerge from strong genetic influence and secondary variants as an adaptation to adversity, such as exposure to childhood maltreatment. However, little research has tested this hypothesis directly. Methods We examined whether anxiety moderates the etiology of CU traits to determine whether this phenotypic feature can help distinguish CU traits with stronger genetic or environmental risk. In two population‐based twin cohorts (initial sample: N = 1,196, aged 6–11, oversampled for exposure to neighborhood disadvantage; follow‐up sample: N = 13,486, age 7), we used genotype‐by‐environment interaction twin modeling to examine if parent‐reported child anxiety moderated the etiology of concurrent parent‐reported child CU traits. Results Anxiety moderated the etiology of CU traits across both samples, such that nonshared environmental influences increased as anxiety increased. Additionally, in the larger sample, genetic influences decreased with increasing anxiety. Conclusions These findings support theories suggesting that co‐occurring anxiety may distinguish CU traits with different origins: CU traits with higher anxiety appear more influenced by nonshared environmental factors—potentially including adversity—and may show weaker genetic influence. Assessing for co‐occurring child anxiety is likely important for diagnosing and personalizing treatments among children with CU traits.
背景:冷酷无情(CU)特征表明青少年有更严重和慢性的行为问题轨迹。然而,CU特征的病因可能是异质性的,这破坏了对有效治疗方法的研究。共同发生的焦虑水平已被用于识别CU特征的“主要”(低焦虑)和“次要”(高焦虑)变体。据推测,主要变异来自强烈的遗传影响,次要变异是对逆境的适应,如童年遭受虐待。然而,很少有研究直接验证这一假设。方法我们研究了焦虑是否会调节CU性状的病因学,以确定这种表型特征是否有助于区分具有较强遗传或环境风险的CU性状。在两个以人群为基础的双胞胎队列中(初始样本:N = 1196,年龄6-11岁,因暴露于邻里不利环境而进行过采样;后续样本:N = 13486,年龄7岁),我们使用基因型-环境相互作用双胞胎模型来检验父母报告的儿童焦虑是否缓解了同时父母报告的儿童CU特征的病因。结果在两个样本中,焦虑调节了CU特征的病因学,例如,非共享环境影响随着焦虑的增加而增加。此外,在更大的样本中,遗传影响随着焦虑程度的增加而降低。结论:这些发现支持了一些理论,即共同发生的焦虑可以区分不同来源的CU性状:焦虑程度高的CU性状受到非共享环境因素(可能包括逆境)的影响更大,而遗传影响可能更弱。评估共同发生的儿童焦虑可能对患有CU特征的儿童的诊断和个性化治疗很重要。
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引用次数: 0
Do early gains deliver lasting impact? Understanding why long-term effects of language intervention fade out 早期的收益会带来持久的影响吗?理解为什么语言干预的长期影响逐渐消失。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-29 DOI: 10.1111/jcpp.70105
Saloni Krishnan, Kristina Moll

Early oral language interventions boost children's language skills, yet we know strikingly little about whether these gains endure. The handful of long-term follow-up studies available suggest that even high-quality language interventions show substantial fade-out. This gap in our evidence base has real consequences for families and for policy, especially as demand for language support continues to rise. We suggest that long-term impact might depend on three levels: characteristics of the intervention (e.g. breadth, instructional approach, and fidelity), features of the learning environment (e.g. classroom ethos, continuity of support, and language resources available) and child-specific factors (e.g. children's cognitive profiles). We call on funders and researchers to prioritise the routine capture of long-term outcomes and to invest in identifying the mechanisms and tools that could drive sustained improvement (e.g. regular booster sessions). We feel this is a critical priority for future research, as it would help us design support that genuinely shifts developmental trajectories.

早期的口头语言干预提高了儿童的语言技能,但我们对这些进步能否持续知之甚少。为数不多的长期随访研究表明,即使是高质量的语言干预也会出现明显的消退。我们证据基础上的这种差距对家庭和政策产生了实际影响,尤其是在对语言支持的需求持续上升的情况下。我们认为,长期影响可能取决于三个层面:干预的特征(如广度、教学方法和保真度)、学习环境的特征(如课堂氛围、支持的连续性和可用的语言资源)和儿童特定因素(如儿童的认知概况)。我们呼吁资助者和研究人员优先考虑长期成果的常规捕获,并投资于确定可以推动持续改进的机制和工具(例如定期助推会)。我们认为这是未来研究的关键优先事项,因为它将帮助我们设计真正改变发展轨迹的支持。
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引用次数: 0
Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk 儿童气质的神经关联:脑网络连通性在精神病理风险中的作用
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-24 DOI: 10.1111/jcpp.70095
Wanze Xie, Yiyi Wang, Dashiell D. Sacks, Charles A. Nelson, Michelle Bosquet Enlow
Background Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. Methods Using a longitudinal cohort followed from infancy to age 7 ( N = 749 collected at infancy), we assessed temperament through two approaches: data‐driven profiles extracted from parent‐reported questionnaires collected from infancy to age 3 and lab‐based assessments of behavioral inhibition (BI) at age 3. Symptoms of psychopathology were measured at age 7 with the parent‐reported Child Behavior Checklist (CBCL). Resting‐state EEG data collected at ages 3, 5, and 7, along with source‐space connectivity methods, were used to examine FC within brain networks. Results Children with an emotionally and behaviorally dysregulated (EBD) profile, an identified risk factor for psychopathology, exhibited reduced FC in the frontoparietal network compared to their emotionally and behaviorally regulated (EBR) peers. BI at age 3 was also negatively correlated with FC in the ventral attention network at age 3 and the frontoparietal network at age 7. Additionally, frontoparietal FC moderated the relationship between early temperament and later attention‐deficit symptoms: EBD children showed higher levels of attention problems than their EBR peers, but only when frontoparietal FC was low. Conclusions These findings underscore the importance of network connectivity in understanding early temperament and its socioemotional outcomes. Specifically, they highlight the role of attention and control networks in the development of psychopathology, suggesting potential targets for early interventions aimed at at‐risk children.
早期气质已被证明可以预测社会情感结果,但其神经相关性尚未完全了解。在本研究中,我们探讨了早期气质与神经网络功能连接(FC)之间的关系,以及这些因素如何影响精神病理风险。方法采用从婴儿期到7岁的纵向队列(N = 749),我们通过两种方法评估气质:从婴儿期到3岁收集的父母报告的问卷中提取数据驱动的档案,以及3岁时基于实验室的行为抑制(BI)评估。在7岁时用家长报告的儿童行为检查表(CBCL)测量精神病理症状。在3岁、5岁和7岁时收集的静息状态脑电图数据,以及源空间连接方法,被用来检查大脑网络中的FC。结果情绪和行为失调(EBD)儿童与情绪和行为失调(EBR)儿童相比,其额顶叶网络中的FC减少,这是一种确定的精神病理学危险因素。3岁时BI与3岁时腹侧注意网络和7岁时额顶叶网络的FC也呈负相关。此外,额顶叶FC调节了早期气质和后期注意缺陷症状之间的关系:EBD儿童比EBR儿童表现出更高水平的注意问题,但只有当额顶叶FC较低时才会如此。这些发现强调了网络连接在理解早期气质及其社会情绪结果中的重要性。具体来说,他们强调了注意力和控制网络在精神病理学发展中的作用,提出了针对高危儿童的早期干预的潜在目标。
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引用次数: 0
Reward-specific learning parameters change across normative adolescent development and are blunted in youth with high risk for depression. 奖励特异性学习参数在青春期的正常发展过程中发生变化,在抑郁症高风险的青少年中变得迟钝。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-22 DOI: 10.1111/jcpp.70086
Holly Sullivan-Toole,Jeremy M Haynes,Helen Schmidt,Bart Larsen,Nathaniel Haines,Thomas M Olino
BACKGROUNDReward learning is thought to undergo refinement in adolescence, but little is known about how computational components of reinforcement learning develop. Given that adolescence is a sensitive period for reward system plasticity with associated vulnerability for depression, it is important to understand developmental trajectories of different reinforcement learning parameters in normative development and in youth at risk for depression.METHODSYouth aged 9-17 years completed the Play-or-Pass Iowa Gambling Task (PoP-IGT) across five timepoints. We calculated task metrics using a traditional scoring approach - yielding summary scores for good deck play, bad deck play, and net play - and a computational modeling approach - yielding parameters for reward learning rate, punishment learning rate, go bias, and sensitivity to win/loss frequency ignoring outcome magnitude. We examined normative developmental trajectories for each traditional and computational performance metric using multilevel models. Further, we examined whether maternal history of depression was associated with individual differences in these trajectories.RESULTSAs hypothesized, youth showed a significant age-related increase in net play (p = 0.003), a measure of overall good performance. Exploratory analyses found that youth showed significant developmental change in reward-specific learning parameters including age-related increases in win/loss frequency sensitivity (FDR  = 0.016) and age-related decreases in reward learning rate (FDR  < 0.001). In line with hypotheses, youth at high risk for depression showed lower reward learning rates in early adolescence (p = 0.041).CONCLUSIONSThe observed developmental changes in traditional and computational metrics are largely consistent with the optimization of learning from rewards across adolescence. Further, the observed developmental changes in specifically reward-related computational parameters are consistent with heightened adolescent reward system plasticity. Additionally, there was support for our hypothesis that maternal history of depression may exert a unique effect on learning from rewards specifically, but further research across additional reward learning tasks is needed.
背景:向前学习被认为在青春期经历了改进,但对于强化学习的计算组件是如何发展的知之甚少。鉴于青春期是奖励系统可塑性的敏感期,与抑郁易感性相关,了解不同强化学习参数在规范发展和抑郁风险青年中的发展轨迹非常重要。方法9-17岁的青少年在5个时间点完成了爱荷华州赌博任务(PoP-IGT)。我们使用传统的评分方法来计算任务指标——得到好的牌、坏的牌和净的牌的总结分数——以及计算建模方法——得到奖励学习率、惩罚学习率、围棋偏差和对输赢频率的敏感性的参数,而忽略了结果的大小。我们使用多层模型检查了每种传统和计算性能指标的规范性发展轨迹。此外,我们研究了母亲的抑郁史是否与这些轨迹的个体差异有关。结果,正如假设的那样,年轻人在净发挥方面表现出显著的年龄相关增长(p = 0.003),这是衡量整体良好表现的指标。探索性分析发现,青少年在奖励特定学习参数方面表现出显著的发展变化,包括与年龄相关的赢/输频率敏感性增加(FDR = 0.016)和与年龄相关的奖励学习率下降(FDR < 0.001)。与假设一致,抑郁症高风险的青少年在青春期早期表现出较低的奖励学习率(p = 0.041)。结论观察到的传统和计算指标的发展变化与青春期奖励学习的优化基本一致。此外,观察到的奖励相关计算参数的发展变化与青少年奖励系统可塑性的增强是一致的。此外,我们的假设得到了支持,即母亲的抑郁史可能对奖励学习产生独特的影响,但需要进一步研究其他奖励学习任务。
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引用次数: 0
Network structure of reward sensitivity and its temporal interactions with depression: a cross-lagged panel network analysis. 奖励敏感性的网络结构及其与抑郁的时间相互作用:一个交叉滞后的面板网络分析。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-19 DOI: 10.1111/jcpp.70094
Xiaoyan Bi,Shutao Ma,Hongbo Cui,Liang Zhang,Yankun Ma
BACKGROUNDReward sensitivity plays a crucial role in shaping emotional and behavioural responses, yet its internal structure and dynamic interplay with depression remain underexplored. This study systematically examined the network structure of reward sensitivity and its associations with depression using a network analysis framework.METHODSBased on two waves of data (T1: N = 1,136, Mage = 14.33, 52.46% female; T2: N = 1,083, Mage = 14.32, 52.82% female), we constructed multiple cross-sectional and bridge networks, as well as a cross-lagged panel network model (CLPN).RESULTS(1) Cross-sectional network analysis reveals that positive feedback serves as the core node in the depression group, while hobbies dominate in the healthy group; (2) bridging network analysis identifies hobbies and positive affect as key bridging nodes linking reward sensitivity and depression; (3) CLPN analysis demonstrates that greater engagement in hobbies at baseline significantly predicts lower levels of depression 6 months later.CONCLUSIONSThis study provided a novel network perspective on the structural and temporal characteristics of reward sensitivity in depression. The findings underscored the importance of targeting specific reward types in intervention strategies and personalised mental health approaches.
正向敏感性在形成情绪和行为反应中起着至关重要的作用,但其内部结构及其与抑郁症的动态相互作用仍未得到充分研究。本研究采用网络分析框架,系统地考察了奖励敏感性的网络结构及其与抑郁的关系。方法基于两波数据(T1: N = 1,136, Mage = 14.33,女性占52.46%;T2: N = 1,083, Mage = 14.32,女性占52.82%),构建多横截面网络和桥梁网络,并构建交叉滞后面板网络模型(CLPN)。结果(1)横断面网络分析显示,抑郁组以正反馈为核心节点,健康组以爱好为主;(2)桥接网络分析发现,爱好和积极情绪是连接奖励敏感性与抑郁的关键桥接节点;(3) CLPN分析表明,在基线时更大的兴趣爱好参与显著预测6个月后抑郁水平的降低。结论本研究为研究抑郁症奖赏敏感性的结构和时间特征提供了新的网络视角。研究结果强调了在干预策略和个性化心理健康方法中针对特定奖励类型的重要性。
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引用次数: 0
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Journal of Child Psychology and Psychiatry
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