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Loneliness patterns across time and subsequent risk of psychotic experiences, depression, anxiety, and diminished well-being in adolescents. 青少年的孤独感模式随时间的变化以及随后的精神病经历、抑郁、焦虑和幸福感下降的风险。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-22 DOI: 10.1111/jcpp.70114
Zui C Narita,Jordan DeVylder,Gemma Knowles,Syudo Yamasaki,Mitsuhiro Miyashita,Daniel Stanyon,Satoshi Yamaguchi,Tomohiro Shinozaki,Ryo Sasaki,Rui Zhou,Shuntaro Ando,Craig Morgan,Paola Dazzan,Toshiaki A Furukawa,Kiyoto Kasai,Ian Kelleher,Atsushi Nishida
BACKGROUNDEvidence on the association between loneliness and psychotic experiences in adolescents remains limited. Moreover, loneliness has typically been assessed at a single time point, which fails to capture its dynamic nature. We hypothesized that persistent loneliness, assessed across repeated measures, would be associated with psychotic experiences and other mental health problems.METHODSUsing longitudinal data from 3,171 participants in the Tokyo Teen Cohort, we applied the g-formula. We analyzed how loneliness patterns at ages 12 and 14 were associated with psychotic experiences, depression, anxiety, and diminished well-being at age 16, accounting for time-fixed and time-varying confounders. Missing data were handled using multiple imputation by chained equations.RESULTSPersistent loneliness was associated with increased risk and greater severity of psychotic experiences (RD 7.1%, 95% CI: 0.8-14.3; RR 2.44, 95% CI: 1.16-4.11; β 0.28, 95% CI: 0.10-0.48). Incident loneliness at age 14 showed similar associations. No association was found for adolescents whose loneliness had remitted by age 14 (RD -1.3%, 95% CI: -3.6 to 1.2; RR 0.73, 95% CI: 0.31-1.26; β 0.01, 95% CI: -0.04 to 0.08). Sensitivity analyses using marginal structural models yielded results that were largely unchanged. Findings were generally similar for other mental health problems. Associations were consistent across genders, although the association with well-being appeared particularly important for girls.CONCLUSIONSThe dynamics of loneliness are associated with a wide range of mental health problems in adolescents. The risk may not be permanent and could be mitigated if loneliness remits. Further research examining interventions that target loneliness is warranted.
背景:关于青少年孤独感和精神病经历之间关系的证据仍然有限。此外,孤独感通常是在一个单一的时间点进行评估的,这无法捕捉到它的动态本质。我们假设,通过重复测量评估,持续的孤独感与精神病经历和其他心理健康问题有关。方法使用来自东京青少年队列的3171名参与者的纵向数据,我们应用g公式。我们分析了12岁和14岁时的孤独模式与16岁时的精神病经历、抑郁、焦虑和幸福感下降之间的关系,并考虑了时间固定和时间变化的混杂因素。缺失数据的处理采用链式方程的多次插值。结果持续的孤独感与精神病经历的风险增加和严重程度增加相关(RD 7.1%, 95% CI: 0.8-14.3; RR 2.44, 95% CI: 1.16-4.11; β 0.28, 95% CI: 0.10-0.48)。14岁时的偶发性孤独也显示出类似的关联。在14岁之前孤独感得到缓解的青少年中没有发现相关性(RD -1.3%, 95% CI: -3.6 ~ 1.2; RR 0.73, 95% CI: 0.31 ~ 1.26; β 0.01, 95% CI: -0.04 ~ 0.08)。使用边际结构模型的敏感性分析得出的结果基本不变。其他心理健康问题的调查结果大致相似。这种关联在性别之间是一致的,尽管与幸福感的关联对女孩来说尤为重要。结论青少年孤独感的动态变化与多种心理健康问题有关。这种风险可能不是永久性的,如果孤独感得到缓解,这种风险可能会得到缓解。有必要进一步研究针对孤独感的干预措施。
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引用次数: 0
Annual Research Review: Self-harm in young people. 年度研究回顾:年轻人的自我伤害。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-21 DOI: 10.1111/jcpp.70112
Dennis Ougrin,Michael Kaess
Self-harm is defined as self-injury or self-poisoning, irrespective of the presence of suicidal intent. It includes both non-suicidal self-injury and attempted suicide. The lifetime prevalence of self-harm is approximately 20% in young people. The initial assessment for self-harm should contain an evaluation of risk, a safety plan and a therapeutic element, which should be focused on understanding the nature of self-harm, instilling hope and linking young people with follow-up treatment. Dialectical Behaviour Therapy should be offered to young people with severe self-harm. School-based interventions, such as the Youth Aware of Mental Health programme, could prevent self-harm in young people.
自我伤害被定义为自我伤害或自我中毒,与是否存在自杀意图无关。它包括非自杀性自残和企图自杀。年轻人一生中自残的发生率约为20%。对自残的初步评估应包括风险评估、安全计划和治疗要素,这些要素应侧重于了解自残的本质,灌输希望,并将年轻人与后续治疗联系起来。对自残严重的青少年应进行辩证行为治疗。以学校为基础的干预措施,如青少年意识到心理健康方案,可以防止年轻人自残。
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引用次数: 0
Eye movements, not reaction times, reveal anticipatory attentional bias in childhood social anxiety disorder. 眼球运动,而不是反应时间,揭示了儿童社交焦虑障碍的预期注意偏差。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-19 DOI: 10.1111/jcpp.70115
Nadine Vietmeier, Nik Dietze, Brunna Tuschen-Caffier, Julia Asbrand

Background: Social anxiety disorder (SAD) is characterized by attentional biases that may contribute to its persistence. While adult models emphasize self-focused and hypervigilant attention, there is limited understanding of how these processes operate in children. This study examined internal and external attentional biases in children with SAD during anticipation of a social stress task-a period when anxiety is typically elevated.

Methods: Forty-two children with a primary SAD diagnosis and 46 healthy controls (HC), aged 9-14 years, completed a reaction time (RT) task with internal (bodily) and external (visual) probes during anticipation of a speech task, while facing a peer video audience. RTs to probes and eye movements toward audience faces were recorded.

Results: RTs did not differ between groups. Exploratory analyses revealed that age correlated negatively with RTs in both groups, suggesting developmental effects on processing speed, although no group differences in this relationship were found. Eye-tracking revealed that children with SAD exhibited more frequent and longer fixations on audience faces during the initial phase of the task compared to HCs.

Conclusions: Although RT tasks alone may not detect attentional biases in children with SAD, eye-tracking indicated heightened attention to socially salient cues during anticipation. These findings highlight the importance of multimodal assessment to capture subtle hypervigilance in pediatric SAD.

背景:社交焦虑障碍(SAD)的特征是注意偏差,这可能有助于其持续存在。虽然成人模式强调自我关注和高度警惕的注意力,但对这些过程如何在儿童中运作的理解有限。这项研究考察了患有SAD的儿童在预期社会压力任务时的内部和外部注意偏差——这是焦虑通常升高的时期。方法:42名原发性SAD儿童和46名健康对照(HC),年龄9-14岁,在面对同伴视频观众时,完成了一项反应时间(RT)任务,其中包括内部(身体)和外部(视觉)探针。他们记录了对探针的反应和眼球对观众面部的运动。结果:两组间RTs无差异。探索性分析显示,两组的年龄与RTs呈负相关,这表明发育对处理速度有影响,尽管这种关系没有发现组间差异。眼球追踪显示,在任务的初始阶段,与正常儿童相比,患有SAD的儿童对观众面孔的注视频率更高,时间更长。结论:虽然RT任务本身不能检测到SAD儿童的注意偏差,但眼动追踪表明,在预期过程中,对社会显著线索的注意程度提高。这些发现强调了多模式评估在儿童SAD中捕捉微妙的过度警觉的重要性。
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引用次数: 0
Annual Research Review: Interventions for young children exposed to trauma. 年度研究回顾:幼儿暴露于创伤的干预措施。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-19 DOI: 10.1111/jcpp.70121
Katherine L Guyon-Harris,Kathryn L Humphreys
The landscape of trauma-focused interventions for young children has evolved significantly, though substantial gaps remain. Early childhood trauma exposure occurs during sensitive periods of brain development with potential lifelong consequences. However, these periods also present unique opportunities for intervention to redirect trajectories toward positive outcomes. Rapid neurodevelopmental changes across early childhood necessitate interventions specifically designed for evolving capacities rather than simply "scaled down" versions of adult treatments. A review focused exclusively on evidence-based interventions for young children is needed. This review represents a synthesis of the literature informed by our clinical and research expertise. We review interventions that (1) target trauma symptoms as primary outcomes, (2) were designed for children ages 0-8 years, (3) include substantive caregiver involvement, and (4) have empirical support from published randomized controlled trials or well-designed quasi-experimental studies. Our review revealed a tiered evidence base for young children, with the strongest support for interventions targeting specific age groups: Child-Parent Psychotherapy for infants and toddlers, Preschool PTSD Treatment for preschoolers, and Trauma-Focused CBT for early elementary children. Critical gaps include limited interventions for children under age 3, sparse evidence for interventions targeting noninterpersonal trauma, assessment challenges, particularly with longitudinal measurement across developmental transitions, and insufficient implementation research on disseminating interventions in community settings. By continuing to refine effective trauma interventions for our youngest children, we can alleviate immediate suffering and potentially prevent decades of associated difficulties across the lifespan. Future research priorities should include expanding the evidence base for existing interventions through well-powered trials with diverse samples, developing and testing preventive interventions delivered following potentially traumatic events, adapting established interventions for under-studied trauma types, and implementation research to support widespread adoption in real-world settings.
针对幼儿的以创伤为重点的干预措施已经有了很大的发展,尽管仍然存在很大的差距。儿童早期创伤暴露发生在大脑发育的敏感时期,具有潜在的终身后果。然而,这些时期也为干预提供了独特的机会,可以将轨迹转向积极的结果。儿童早期神经发育的快速变化需要专门针对能力发展而设计的干预措施,而不是简单地“缩小”成人治疗的版本。有必要专门审查以证据为基础的幼儿干预措施。这篇综述综合了我们临床和研究方面的专业知识。我们回顾了以下干预措施:(1)以创伤症状为主要结局,(2)为0-8岁儿童设计,(3)包括实质性照顾者参与,(4)有已发表的随机对照试验或设计良好的准实验研究的经验支持。我们的回顾揭示了一个针对幼儿的分层证据基础,并强烈支持针对特定年龄组的干预措施:针对婴幼儿的亲子心理治疗,针对学龄前儿童的学前创伤后应激障碍治疗,以及针对小学早期儿童的创伤焦点CBT。关键的差距包括针对3岁以下儿童的干预措施有限,针对非人际创伤的干预措施证据不足,评估方面的挑战,特别是在发展过渡期间的纵向测量方面,以及在社区环境中传播干预措施的实施研究不足。通过对我们最小的孩子不断改进有效的创伤干预,我们可以减轻他们眼前的痛苦,并有可能在整个生命周期中预防数十年的相关困难。未来的研究重点应包括:通过不同样本的有力试验,扩大现有干预措施的证据基础;开发和测试潜在创伤事件后提供的预防性干预措施;针对研究不足的创伤类型调整已建立的干预措施;以及实施研究,以支持在现实环境中广泛采用。
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引用次数: 0
Evaluating placebo responses to intranasal oxytocin in autism: findings from the placebo lead-in phase of a randomised controlled trial. 评估自闭症患者鼻内催产素对安慰剂的反应:一项随机对照试验的安慰剂引入阶段的发现。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-19 DOI: 10.1111/jcpp.70116
Kelsie A Boulton,Rinku Thapa,Yun Ju Song,Andrew J O Whitehouse,Marilena M DeMayo,Simon G Gregory,Izabella Pokorski,Joanna Granich,Zahava Ambarchi,John Wray,Emma E Thomas,Ian B Hickie,Adam J Guastella
BACKGROUNDThe placebo effect is established in clinical trials, but for paediatric research, questions remain about how to best manage its influence. Within the autism field, data on these issues is sparse. This is particularly important in the oxytocin field where placebo responses are thought to play an important role. This study reports on data from the single-blind, placebo lead-in phase of a randomised controlled trial (RCT) to investigate the placebo response and its relationship to treatment response in autistic children.METHODSEighty-seven autistic children aged 3-12 years (M = 7.27; SD = 2.69; 85.1% male) were consecutively recruited into a multi-site RCT evaluating the efficacy of oxytocin for improving social responsiveness. Participants underwent a 3-week, single-blind placebo lead-in before randomisation into a 12-week double-blind treatment phase (oxytocin, n = 45; placebo, n = 42). The Social Responsiveness Scale, 2nd Edition (SRS-2) Total Raw Score was used to measure change from baseline to post-placebo lead-in. A ≥10-point improvement defined placebo responders.RESULTSNearly half the sample (n = 42, 48.3%) were identified as placebo responders during the lead-in phase, showing a clinically significant degree of change on the SRS-2. Caregiver treatment guess did not significantly impact the placebo response (p = .534). Placebo response was associated with greater symptom severity (r's > -.23; p-values < .037) and higher cognitive ability (r = -.35, p = .004). Smaller placebo responses during the lead-in phase were associated with larger responses during active treatment in participants receiving oxytocin (r = -.36, p = .017). Placebo responses during the lead-in phase were observed across all caregiver-reported measures (Cohen's d = .19-.65).CONCLUSIONSThis study provides important information about placebo effects and placebo lead-in designs for clinical trials in the autism field. We show widespread clinically significant improvement during placebo lead-in, utility of identifying placebo responders for informing clinical trial analyses, similarities in symptom measure effect sizes for placebo effects, and a lack of influence of caregiver beliefs on placebo responses.
背景:安慰剂效应在临床试验中得到证实,但在儿科研究中,如何最好地控制其影响仍是一个问题。在自闭症领域,关于这些问题的数据很少。这在催产素领域尤其重要,因为安慰剂反应被认为起着重要作用。本研究报告了一项随机对照试验(RCT)的单盲、安慰剂导入阶段的数据,该试验旨在调查自闭症儿童的安慰剂反应及其与治疗反应的关系。方法选取87例3 ~ 12岁自闭症儿童(M = 7.27, SD = 2.69,男性85.1%),采用多点随机对照试验,评价催产素对改善社交反应的效果。在随机分配到12周的双盲治疗阶段(催产素,n = 45;安慰剂,n = 42)之前,参与者接受了为期3周的单盲安慰剂治疗。社会反应性量表,第二版(SRS-2)总原始得分用于测量从基线到安慰剂引入后的变化。≥10分的改善定义为安慰剂应答者。结果近一半的样本(n = 42, 48.3%)在先导阶段被确定为安慰剂应答者,在SRS-2上显示出临床显著程度的变化。照顾者治疗猜测对安慰剂反应没有显著影响(p = .534)。安慰剂反应与更严重的症状相关(r's bb0 - 0.23; p值<。037)和更高的认知能力(r = - 0.35, p = 0.004)。在引入阶段较小的安慰剂反应与接受催产素的参与者在积极治疗期间的较大反应相关(r = - 0.36, p = 0.017)。在所有护理人员报告的测量中,在引入阶段观察到安慰剂反应(Cohen’s d = 0.19 - 0.65)。结论本研究为孤独症临床试验提供了有关安慰剂效应和安慰剂导入设计的重要信息。我们展示了在安慰剂引入期间广泛的临床显著改善,确定安慰剂应答者为临床试验分析提供信息的效用,安慰剂效应的症状测量效应大小的相似性,以及缺乏护理者信念对安慰剂反应的影响。
{"title":"Evaluating placebo responses to intranasal oxytocin in autism: findings from the placebo lead-in phase of a randomised controlled trial.","authors":"Kelsie A Boulton,Rinku Thapa,Yun Ju Song,Andrew J O Whitehouse,Marilena M DeMayo,Simon G Gregory,Izabella Pokorski,Joanna Granich,Zahava Ambarchi,John Wray,Emma E Thomas,Ian B Hickie,Adam J Guastella","doi":"10.1111/jcpp.70116","DOIUrl":"https://doi.org/10.1111/jcpp.70116","url":null,"abstract":"BACKGROUNDThe placebo effect is established in clinical trials, but for paediatric research, questions remain about how to best manage its influence. Within the autism field, data on these issues is sparse. This is particularly important in the oxytocin field where placebo responses are thought to play an important role. This study reports on data from the single-blind, placebo lead-in phase of a randomised controlled trial (RCT) to investigate the placebo response and its relationship to treatment response in autistic children.METHODSEighty-seven autistic children aged 3-12 years (M = 7.27; SD = 2.69; 85.1% male) were consecutively recruited into a multi-site RCT evaluating the efficacy of oxytocin for improving social responsiveness. Participants underwent a 3-week, single-blind placebo lead-in before randomisation into a 12-week double-blind treatment phase (oxytocin, n = 45; placebo, n = 42). The Social Responsiveness Scale, 2nd Edition (SRS-2) Total Raw Score was used to measure change from baseline to post-placebo lead-in. A ≥10-point improvement defined placebo responders.RESULTSNearly half the sample (n = 42, 48.3%) were identified as placebo responders during the lead-in phase, showing a clinically significant degree of change on the SRS-2. Caregiver treatment guess did not significantly impact the placebo response (p = .534). Placebo response was associated with greater symptom severity (r's > -.23; p-values < .037) and higher cognitive ability (r = -.35, p = .004). Smaller placebo responses during the lead-in phase were associated with larger responses during active treatment in participants receiving oxytocin (r = -.36, p = .017). Placebo responses during the lead-in phase were observed across all caregiver-reported measures (Cohen's d = .19-.65).CONCLUSIONSThis study provides important information about placebo effects and placebo lead-in designs for clinical trials in the autism field. We show widespread clinically significant improvement during placebo lead-in, utility of identifying placebo responders for informing clinical trial analyses, similarities in symptom measure effect sizes for placebo effects, and a lack of influence of caregiver beliefs on placebo responses.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"38 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conduct disorder with limited prosocial emotions: a multimethod study in criminal justice-involved boys. 行为障碍伴有限亲社会情绪:涉及刑事司法的男孩的多方法研究。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-15 DOI: 10.1111/jcpp.70118
Olivier F Colins,Thomas Cassart,Emmely Delamillieure,Kostas A Fanti,Melina Nicole Kyranides,Maria Sikki,Maria Petridou,Paul H F Meens
BACKGROUNDMore than 10 years after its introduction in DSM-5, support for the 'limited prosocial emotions' specifier (LPE) for the diagnosis of conduct disorder (CD) remains scarce, possibly because studies failed to comprehensively assess the specifier and to include important characteristics. This study was designed to tackle both major limitations.METHODSIn a sample of 323 criminal justice-involved male adolescents (ages 16-17 years), diagnostic interviews were used to differentiate between males who meet criteria for both CD and the DSM-5 specifier (CD + LPE) and males who only meet criteria for CD (CD Only). Individual and environmental characteristics were measured by means of questionnaires and computerized tasks.RESULTSThe CD + LPE (vs. CD Only) group exhibited higher levels of aggression, delay discounting, and boldness, was more likely to be expelled from school, and had significantly more delinquent friends. Levels of treatment engagement and empathy also were lower in the CD + LPE group. The DSM-5 LPE specifier significantly added to the prediction of various of these characteristics beyond indices of CD severity (i.e., total number of CD symptoms and childhood-onset CD) and features of attention-deficit/hyperactivity disorder. However, no significant group differences emerged for other characteristics (e.g., emotion recognition accuracy, anxiety, sensation seeking, response inhibition, and warm parenting).CONCLUSIONSFindings provide important and novel evidence to support the utility of the DSM-5 LPE specifier for CD. Some findings were unexpected, though, underscoring the need to replicate and extend the current results when testing the viability of this specifier.
背景:在DSM-5中引入“有限亲社会情绪”描述物(LPE) 10多年后,对其用于诊断品行障碍(CD)的支持仍然很少,这可能是因为研究未能全面评估描述物并包括重要特征。本研究旨在解决这两个主要的限制。方法对323名涉及刑事司法的男性青少年(16-17岁)进行诊断性访谈,以区分既符合CD标准又符合DSM-5规定(CD + LPE)的男性和只符合CD标准(CD only)的男性。个体特征和环境特征通过问卷调查和计算机任务进行测量。结果CD + LPE组(与仅CD组相比)表现出更高的攻击性、延迟折扣和大胆程度,更有可能被学校开除,并且有更多的不良朋友。CD + LPE组的治疗投入和同理心水平也较低。DSM-5 LPE指标显著增加了对各种CD严重程度指标(即CD症状总数和儿童期发病CD)和注意缺陷/多动障碍特征之外的这些特征的预测。然而,在其他特征(如情绪识别的准确性、焦虑、感觉寻求、反应抑制和温暖的养育方式)上没有显著的组间差异。结论:研究结果为支持DSM-5 LPE描述物对CD的效用提供了重要和新颖的证据。然而,一些发现是出乎意料的,强调在测试该描述物的可行性时需要复制和扩展当前的结果。
{"title":"Conduct disorder with limited prosocial emotions: a multimethod study in criminal justice-involved boys.","authors":"Olivier F Colins,Thomas Cassart,Emmely Delamillieure,Kostas A Fanti,Melina Nicole Kyranides,Maria Sikki,Maria Petridou,Paul H F Meens","doi":"10.1111/jcpp.70118","DOIUrl":"https://doi.org/10.1111/jcpp.70118","url":null,"abstract":"BACKGROUNDMore than 10 years after its introduction in DSM-5, support for the 'limited prosocial emotions' specifier (LPE) for the diagnosis of conduct disorder (CD) remains scarce, possibly because studies failed to comprehensively assess the specifier and to include important characteristics. This study was designed to tackle both major limitations.METHODSIn a sample of 323 criminal justice-involved male adolescents (ages 16-17 years), diagnostic interviews were used to differentiate between males who meet criteria for both CD and the DSM-5 specifier (CD + LPE) and males who only meet criteria for CD (CD Only). Individual and environmental characteristics were measured by means of questionnaires and computerized tasks.RESULTSThe CD + LPE (vs. CD Only) group exhibited higher levels of aggression, delay discounting, and boldness, was more likely to be expelled from school, and had significantly more delinquent friends. Levels of treatment engagement and empathy also were lower in the CD + LPE group. The DSM-5 LPE specifier significantly added to the prediction of various of these characteristics beyond indices of CD severity (i.e., total number of CD symptoms and childhood-onset CD) and features of attention-deficit/hyperactivity disorder. However, no significant group differences emerged for other characteristics (e.g., emotion recognition accuracy, anxiety, sensation seeking, response inhibition, and warm parenting).CONCLUSIONSFindings provide important and novel evidence to support the utility of the DSM-5 LPE specifier for CD. Some findings were unexpected, though, underscoring the need to replicate and extend the current results when testing the viability of this specifier.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"8 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive affect as a developmental mediator of early adversity and internalizing psychopathology 积极情感作为早期逆境和内化精神病理的发展中介
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-14 DOI: 10.1111/jcpp.70104
Jamie L. Hanson, Dorthea J. Adkins, Isabella Kahhale, Sriparna Sen
Background Early life adversities (ELAs) including experiences such as abuse, neglect, and household dysfunction are strongly linked to psychopathology; yet, the developmental pathways connecting ELA to externalizing and internalizing psychopathology remain unclear. While most research has focused on threat and negative affect, positive emotions may represent a critical but understudied mechanism linking ELA to mental health outcomes. Methods Using data from the Adolescent Brain Cognitive Development (ABCD) study, we examined positive affect trajectories across six timepoints spanning childhood through adolescence (ages 9–10 to 12–13). We employed person‐centered trajectory‐based clustering to identify distinct patterns in positive affect – independent of ELA exposure – followed by multinomial logistic regression to examine associations between cumulative ELA exposure and trajectory membership. Mediation analyses tested whether positive affect trajectories explained links between ELA and psychopathology outcomes. Results Four distinct positive affect trajectories emerged: High‐Stable, Declining, Persistently Low, and Volatile ( N = 7,457). Higher ELA scores significantly predicted membership in all non‐high‐stable trajectories, with the strongest association existing for the Persistently Low group (β = .321, p < .001). Mediation analyses revealed that Persistently Low trajectory group membership significantly mediated the relationship between ELA and internalizing problems (indirect effect = 0.030, 95% CI [0.012, 0.056], p = .007), but not externalizing problems ( N = 3,927). Conclusions This study demonstrates that ELA shapes positive affect development through distinct, heterogeneous pathways rather than uniform effects, with persistently low positive affect representing a specific mechanism linking early adversity to later depression and anxiety. Findings suggest that targeting positive emotional experiences may be a promising intervention strategy for youth exposed to ELA.
早期生活逆境(ELAs)包括虐待、忽视和家庭功能障碍等经历与精神病理密切相关;然而,将ELA与外化和内化精神病理联系起来的发展途径仍不清楚。虽然大多数研究都集中在威胁和负面影响上,但积极情绪可能是将ELA与心理健康结果联系起来的一个关键但尚未得到充分研究的机制。方法利用青少年大脑认知发展(ABCD)研究的数据,研究了从童年到青春期(9-10岁到12-13岁)的六个时间点的积极影响轨迹。我们采用以人为中心的基于轨迹的聚类来确定积极影响的不同模式-独立于ELA暴露-然后采用多项逻辑回归来检查累积ELA暴露和轨迹成员之间的关联。中介分析测试了积极影响轨迹是否解释了ELA和精神病理结果之间的联系。结果出现了四种不同的积极影响轨迹:高稳定、下降、持续低和波动(N = 7,457)。较高的ELA分数显著地预测了所有非高稳定轨迹的成员资格,其中持续低水平组存在最强的关联(β = 0.321, p < .001)。中介分析显示,持续低轨迹群体成员显著调节了环境影响因素与内化问题的关系(间接效应= 0.030,95% CI [0.012, 0.056], p = 0.007),但对外化问题没有影响(N = 3,927)。本研究表明,ELA通过不同的、异构的途径而不是统一的效应来塑造积极情绪的发展,持续的低积极情绪代表了一种将早期逆境与后来的抑郁和焦虑联系起来的特定机制。研究结果表明,针对积极情绪体验可能是一种有希望的干预策略。
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引用次数: 0
Prenatal exposure to ambient air pollution and risk of neurodevelopmental disorders in offspring: A nationwide population-based cohort study. 产前暴露于环境空气污染和后代神经发育障碍的风险:一项基于全国人群的队列研究。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-14 DOI: 10.1111/jcpp.70120
Tak Kyu Oh,In-Ae Song
BACKGROUNDPrenatal exposure to ambient air pollution has been implicated in adverse neurodevelopment, but evidence from large-scale, long-term studies in Asian populations remains limited. We examined the association between in utero exposure to multiple air pollutants and the risk of neurodevelopmental disorders (NDD) in offspring using a nationwide cohort in South Korea.METHODSWe conducted a nationwide retrospective cohort study using linked administrative health and environmental data. A total of 1,436,685 children born between January 1, 2010, and December 31, 2014, were identified from the National Health Insurance Service database and followed up through December 31, 2023. Maternal exposure to nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), ozone (O3), and particulate matter ≤10 μm (PM10) was estimated by linking residential postal codes to fixed-site monitoring data. NDD diagnoses were identified from healthcare claims. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models adjusting for maternal sociodemographic, medical, obstetric, and neonatal covariates.RESULTSDuring up to 13 years of follow-up, 140,971 children (9.8%) were diagnosed with an NDD. Prenatal exposure to NO2 showed the strongest association: each 0.01-ppm increase was associated with an 18% higher hazard of NDD (aHR 1.18, 95% CI 1.17-1.19; p < .001). SO2 exposure also demonstrated a small but statistically significant association (per 0.001-ppm increase: aHR 1.01, 95% CI 1.01-1.02; p = .008). These associations persisted across major NDD subtypes - including intellectual disabilities, developmental delays, and behavioral or emotional disorders - and remained robust in trimester-specific, stratified, and sensitivity analyses.CONCLUSIONSPrenatal exposure to ambient air pollutants - particularly NO2 and SO2 - is associated with increased long-term risk of NDD in offspring. These findings highlight the neurodevelopmental vulnerability of the prenatal period and underscore the need for strengthened environmental policies to reduce maternal exposure to harmful pollutants.
产前暴露于环境空气污染与神经发育不良有关,但在亚洲人群中进行的大规模、长期研究的证据仍然有限。我们使用韩国全国队列研究了子宫内暴露于多种空气污染物与后代神经发育障碍(NDD)风险之间的关系。方法:我们利用相关的行政卫生和环境数据进行了一项全国性的回顾性队列研究。在2010年1月1日至2014年12月31日期间出生的1,436,685名儿童从国民健康保险服务数据库中被确定,并随访至2023年12月31日。通过将住宅邮政编码与固定站点监测数据联系起来,估计产妇对二氧化氮(NO2)、二氧化硫(SO2)、一氧化碳(CO)、臭氧(O3)和≤10 μm颗粒物(PM10)的暴露量。NDD诊断是从医疗保健声明中确定的。使用多变量Cox比例风险模型对产妇社会人口统计学、医学、产科和新生儿协变量进行校正,估计校正风险比(ahr)和95%置信区间(ci)。结果在长达13年的随访期间,140,971名儿童(9.8%)被诊断为NDD。产前NO2暴露表现出最强的相关性:每增加0.01 ppm, NDD的风险增加18% (aHR 1.18, 95% CI 1.17-1.19; p < .001)。二氧化硫暴露也显示出较小但有统计学意义的关联(每0.001-ppm增加:aHR 1.01, 95% CI 1.01-1.02; p = 0.008)。这些关联在主要的NDD亚型(包括智力障碍、发育迟缓和行为或情绪障碍)中持续存在,并且在妊娠期特异性、分层和敏感性分析中保持强劲。结论:产前暴露于环境空气污染物(特别是二氧化氮和二氧化硫)与后代NDD的长期风险增加有关。这些发现突出了产前期的神经发育脆弱性,并强调了加强环境政策以减少产妇接触有害污染物的必要性。
{"title":"Prenatal exposure to ambient air pollution and risk of neurodevelopmental disorders in offspring: A nationwide population-based cohort study.","authors":"Tak Kyu Oh,In-Ae Song","doi":"10.1111/jcpp.70120","DOIUrl":"https://doi.org/10.1111/jcpp.70120","url":null,"abstract":"BACKGROUNDPrenatal exposure to ambient air pollution has been implicated in adverse neurodevelopment, but evidence from large-scale, long-term studies in Asian populations remains limited. We examined the association between in utero exposure to multiple air pollutants and the risk of neurodevelopmental disorders (NDD) in offspring using a nationwide cohort in South Korea.METHODSWe conducted a nationwide retrospective cohort study using linked administrative health and environmental data. A total of 1,436,685 children born between January 1, 2010, and December 31, 2014, were identified from the National Health Insurance Service database and followed up through December 31, 2023. Maternal exposure to nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), ozone (O3), and particulate matter ≤10 μm (PM10) was estimated by linking residential postal codes to fixed-site monitoring data. NDD diagnoses were identified from healthcare claims. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models adjusting for maternal sociodemographic, medical, obstetric, and neonatal covariates.RESULTSDuring up to 13 years of follow-up, 140,971 children (9.8%) were diagnosed with an NDD. Prenatal exposure to NO2 showed the strongest association: each 0.01-ppm increase was associated with an 18% higher hazard of NDD (aHR 1.18, 95% CI 1.17-1.19; p < .001). SO2 exposure also demonstrated a small but statistically significant association (per 0.001-ppm increase: aHR 1.01, 95% CI 1.01-1.02; p = .008). These associations persisted across major NDD subtypes - including intellectual disabilities, developmental delays, and behavioral or emotional disorders - and remained robust in trimester-specific, stratified, and sensitivity analyses.CONCLUSIONSPrenatal exposure to ambient air pollutants - particularly NO2 and SO2 - is associated with increased long-term risk of NDD in offspring. These findings highlight the neurodevelopmental vulnerability of the prenatal period and underscore the need for strengthened environmental policies to reduce maternal exposure to harmful pollutants.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"46 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivariate maternal effects across the internalizing-externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study. 儿童期内化-外化光谱的多变量母亲效应:来自挪威母亲、父亲和儿童队列研究的结果。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-13 DOI: 10.1111/jcpp.70111
Espen Moen Eilertsen,Nikolai Haahjem Eftedal,Rosa Cheesman,Ziada Ayorech,Joakim Coleman Ebeltoft,Hans Fredrik Sunde,Anneli Desiré Tandberg,Fartein Ask Torvik,Eivind Ystrom
BACKGROUNDFrom a functionalist perspective, parenting behaviors have adaptive functions and are partly expressions of genetic variation. Maternal genes that have effects on children are often referred to as indirect maternal genetic effects. Indirect genetic effects provide a means for measuring the role of parenting without the need for specifying the relevant parental behaviors. We studied indirect maternal genetic effects to address both the importance and commonality of parenting across the internalizing-externalizing spectrum of behavior problems in childhood. We further addressed how indirect genetic effects impact our understanding of direct genetic effects if not accounted for.METHODSUtilizing data from the Norwegian Mother, Father, and Child Cohort Study (MoBa), our analyses involved 42,423 children and their mothers. Both pedigree and genotype data were used to infer genetic relationships. We applied multivariate latent variable models to distinguish indirect maternal genetic effects and direct offspring genetic effects on seven measures of internalizing-externalizing behaviors.RESULTSOur findings indicate significant maternal genetic influences, explaining 7%-18% of the variance across internalizing-externalizing behaviors. A general maternal effect common across behaviors could adequately account for most of the variability. The analyses further indicate that direct child genetic effects appear smaller and more complex when indirect maternal genetic effects are modeled simultaneously.CONCLUSIONSBy summarizing the effects of parenting with indirect maternal genetic effects, we show a substantial contribution of parents with respect to internalizing-externalizing behaviors in childhood. Although parenting is multifaceted, the effects of parenting are general and can succinctly be described as a single common dimension. Further, our study demonstrates that direct genetic effects appear smaller and more complex when maternal genetic effects are accounted for, highlighting the confounding potential of parental effects in understanding the role of genetic differences in child psychopathology.
从功能主义的角度来看,养育行为具有适应功能,部分是遗传变异的表现。对儿童产生影响的母系基因通常被称为间接母系遗传效应。间接遗传效应提供了一种方法来衡量父母的作用,而不需要具体说明相关的父母行为。我们研究了间接的母亲遗传效应,以解决在童年行为问题的内在化-外在化谱系中养育的重要性和共性。我们进一步讨论了间接遗传效应如何影响我们对直接遗传效应的理解,如果没有解释。方法利用挪威母亲、父亲和儿童队列研究(MoBa)的数据,我们的分析涉及42,423名儿童及其母亲。家系和基因型数据被用来推断遗传关系。我们应用多变量潜变量模型来区分内化-外化行为的七种测量指标的间接母系遗传效应和直接子代遗传效应。结果母亲遗传因素对内化-外化行为的影响显著,解释了7%-18%的内化-外化行为差异。在行为中普遍存在的母性效应可以充分解释大部分的可变性。分析进一步表明,当同时模拟间接的母亲遗传效应时,直接的儿童遗传效应显得更小、更复杂。结论通过总结父母的间接遗传效应,我们发现父母对儿童的内化-外化行为有很大的影响。虽然养育子女是多方面的,但养育子女的影响是普遍的,可以简洁地描述为一个共同的维度。此外,我们的研究表明,当考虑到母亲的遗传效应时,直接遗传效应显得更小、更复杂,这突出了父母效应在理解遗传差异在儿童精神病理学中的作用方面的混淆潜力。
{"title":"Multivariate maternal effects across the internalizing-externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study.","authors":"Espen Moen Eilertsen,Nikolai Haahjem Eftedal,Rosa Cheesman,Ziada Ayorech,Joakim Coleman Ebeltoft,Hans Fredrik Sunde,Anneli Desiré Tandberg,Fartein Ask Torvik,Eivind Ystrom","doi":"10.1111/jcpp.70111","DOIUrl":"https://doi.org/10.1111/jcpp.70111","url":null,"abstract":"BACKGROUNDFrom a functionalist perspective, parenting behaviors have adaptive functions and are partly expressions of genetic variation. Maternal genes that have effects on children are often referred to as indirect maternal genetic effects. Indirect genetic effects provide a means for measuring the role of parenting without the need for specifying the relevant parental behaviors. We studied indirect maternal genetic effects to address both the importance and commonality of parenting across the internalizing-externalizing spectrum of behavior problems in childhood. We further addressed how indirect genetic effects impact our understanding of direct genetic effects if not accounted for.METHODSUtilizing data from the Norwegian Mother, Father, and Child Cohort Study (MoBa), our analyses involved 42,423 children and their mothers. Both pedigree and genotype data were used to infer genetic relationships. We applied multivariate latent variable models to distinguish indirect maternal genetic effects and direct offspring genetic effects on seven measures of internalizing-externalizing behaviors.RESULTSOur findings indicate significant maternal genetic influences, explaining 7%-18% of the variance across internalizing-externalizing behaviors. A general maternal effect common across behaviors could adequately account for most of the variability. The analyses further indicate that direct child genetic effects appear smaller and more complex when indirect maternal genetic effects are modeled simultaneously.CONCLUSIONSBy summarizing the effects of parenting with indirect maternal genetic effects, we show a substantial contribution of parents with respect to internalizing-externalizing behaviors in childhood. Although parenting is multifaceted, the effects of parenting are general and can succinctly be described as a single common dimension. Further, our study demonstrates that direct genetic effects appear smaller and more complex when maternal genetic effects are accounted for, highlighting the confounding potential of parental effects in understanding the role of genetic differences in child psychopathology.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"25 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annual Research Review: The role of caregiver sensitivity in children's developmental outcomes - an umbrella review. 年度研究回顾:照顾者敏感性在儿童发展结果中的作用-总括性回顾。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-07 DOI: 10.1111/jcpp.70087
Marissa D Nivison, Pasco Fearon, Jennifer M Jenkins, Sheri Madigan

Caregiver sensitivity is the extent to which a caregiver notices a child's signal, interprets it correctly, and responds quickly and appropriately. Although originally introduced to developmental science as the key antecedent of attachment security, decades since its conception, hundreds of studies have been conducted examining the predictive significance of caregiver sensitivity to a broad range of developmental outcomes. The literature on caregiver sensitivity and related constructs (e.g., warmth, responsivity, negative parenting) has grown exponentially and is now the focus of several meta-analyses. We conducted an umbrella review - a systematic review of reviews - to examine the extent to which caregiver sensitivity and related constructs are associated with child attachment, socioemotional, and cognitive outcomes. Searches in EMBASE, PsycINFO, and Medline and yielded 2,157 abstracts. Studies were included if they were a meta-analysis of caregiver sensitivity or a related construct, focused on children's developmental outcomes, were available in English, French, or Spanish, and were published between 2010 and 2024. Conducted and reported in accordance with PRISMA guidelines, 17 meta-analyses were identified. Using the metaumbrella package in R, we conducted quantitative analyses which demonstrated that caregiver sensitivity was moderately associated with attachment security (r = .25, k = 253, n = 37,444), cognition (r = .23, k = 44, n = 6,777), language skills (r = .26, k = 54, n = 11,136), and weakly associated with socioemotional problems (r = -.07, k = 135, n = 33,305). Narrative analysis of other meta-analyses on caregiver warmth, responsivity, positive and negative parenting, and child outcomes also showed associations in the expected direction. Our findings demonstrate the critical importance of caregiver sensitivity on children's socioemotional and cognitive development, supporting caregiver sensitivity as an important target for early childhood prevention and intervention programs.

照顾者的敏感性是照顾者注意到孩子的信号,正确地解释它,并迅速和适当地作出反应的程度。虽然最初是作为依恋安全的关键前提引入发展科学的,但在其概念提出几十年后,已经进行了数百项研究,以检验照顾者敏感性对广泛发展结果的预测意义。关于照顾者敏感性和相关结构(例如,温暖、反应性、消极养育)的文献呈指数级增长,现在是几个元分析的焦点。我们进行了一项总括性的综述——一项综述的系统综述——来研究照顾者敏感性和相关构念与儿童依恋、社会情感和认知结果的关联程度。在EMBASE、PsycINFO和Medline中搜索,得到2157篇摘要。如果研究是对照顾者敏感性的荟萃分析或相关结构,关注儿童的发展结果,以英语、法语或西班牙语提供,并在2010年至2024年之间发表,则纳入研究。根据PRISMA指南进行和报告,确定了17项荟萃分析。使用R中的元伞包,我们进行了定量分析,结果表明照顾者敏感性与依恋安全性有中度相关(R =。25, k = 253, n = 37,444),认知(r =。23, k = 44, n = 6,777),语言技能(r =。26, k = 54, n = 11,136),与社会情绪问题的相关性较弱(r = - 0.07, k = 135, n = 33,305)。对其他关于照顾者温暖度、反应性、积极和消极养育方式与儿童结局的元分析的叙述分析也显示出与预期方向的关联。我们的研究结果表明,照顾者敏感性对儿童的社会情感和认知发展至关重要,支持照顾者敏感性作为儿童早期预防和干预计划的重要目标。
{"title":"Annual Research Review: The role of caregiver sensitivity in children's developmental outcomes - an umbrella review.","authors":"Marissa D Nivison, Pasco Fearon, Jennifer M Jenkins, Sheri Madigan","doi":"10.1111/jcpp.70087","DOIUrl":"https://doi.org/10.1111/jcpp.70087","url":null,"abstract":"<p><p>Caregiver sensitivity is the extent to which a caregiver notices a child's signal, interprets it correctly, and responds quickly and appropriately. Although originally introduced to developmental science as the key antecedent of attachment security, decades since its conception, hundreds of studies have been conducted examining the predictive significance of caregiver sensitivity to a broad range of developmental outcomes. The literature on caregiver sensitivity and related constructs (e.g., warmth, responsivity, negative parenting) has grown exponentially and is now the focus of several meta-analyses. We conducted an umbrella review - a systematic review of reviews - to examine the extent to which caregiver sensitivity and related constructs are associated with child attachment, socioemotional, and cognitive outcomes. Searches in EMBASE, PsycINFO, and Medline and yielded 2,157 abstracts. Studies were included if they were a meta-analysis of caregiver sensitivity or a related construct, focused on children's developmental outcomes, were available in English, French, or Spanish, and were published between 2010 and 2024. Conducted and reported in accordance with PRISMA guidelines, 17 meta-analyses were identified. Using the metaumbrella package in R, we conducted quantitative analyses which demonstrated that caregiver sensitivity was moderately associated with attachment security (r = .25, k = 253, n = 37,444), cognition (r = .23, k = 44, n = 6,777), language skills (r = .26, k = 54, n = 11,136), and weakly associated with socioemotional problems (r = -.07, k = 135, n = 33,305). Narrative analysis of other meta-analyses on caregiver warmth, responsivity, positive and negative parenting, and child outcomes also showed associations in the expected direction. Our findings demonstrate the critical importance of caregiver sensitivity on children's socioemotional and cognitive development, supporting caregiver sensitivity as an important target for early childhood prevention and intervention programs.</p>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Child Psychology and Psychiatry
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