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Reflecting on child effects in psychology and psychiatry research 心理学和精神病学研究中的儿童效应反思
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-16 DOI: 10.1111/jcpp.70084
Mark Wade, Lydia M. Li, Stephan Collishaw
The authors explore publication trends in the Journal of Child Psychology and Psychiatry over the past 5 years regarding associations between parenting and child outcomes, with a focus on the directionality of these effects. Bibliometric analysis revealed that far more studies have examined parent‐to‐child associations than either child‐to‐parent or bidirectional associations, reflecting a significant imbalance in what researchers publishing in JCPP intend to study. However, when evaluating evidence from a subset of robust and well‐designed studies, especially those that permit a test of bidirectionality, the authors see a more balanced picture, with a roughly equal number of studies finding evidence of parent‐to‐child, child‐to‐parent, and bidirectional effects. These studies used a range of methodologies and examined a diverse set of parenting behaviors and child outcomes. Overall, the findings suggest that evidence in favor of child effects is consistently observed despite being significantly understudied relative to that of parent effects. The authors emphasize the importance of studying both child and parent effects alongside one another to understand the complexity of parent–child interactions, and underscore how respect for the agency and perspectives of youth is essential to understanding how they shape the conditions in which they grow up.
作者探讨了《儿童心理学和精神病学杂志》在过去5年里关于养育子女和孩子成长之间关系的出版趋势,重点关注了这些影响的方向性。文献计量学分析显示,研究亲子关系的研究远远多于研究亲子关系或双向关系的研究,这反映了在JCPP上发表文章的研究人员意图研究的显著不平衡。然而,当评估来自一组可靠且设计良好的研究的证据时,特别是那些允许双向性测试的研究,作者看到了一个更加平衡的画面,发现父母对孩子、孩子对父母和双向效应的证据的研究数量大致相等。这些研究使用了一系列的方法,检查了不同的父母行为和孩子的结果。总的来说,研究结果表明,尽管与父母效应相比,对儿童效应的研究明显不足,但支持儿童效应的证据一直被观察到。作者强调了同时研究孩子和父母的影响对理解亲子互动的复杂性的重要性,并强调了尊重年轻人的代理和观点对于理解他们如何塑造他们成长的环境是至关重要的。
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引用次数: 0
Smartphone language and resting‐state EEG indicators of self‐focused attention prospectively predict major depressive disorder risk in adolescents 智能手机语言和静息状态脑电图自我集中注意力指标对青少年重度抑郁症风险的前瞻性预测
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-16 DOI: 10.1111/jcpp.70096
Lilian Y. Li, Nayoung Kim, Esha Trivedi, Sarah E. Sarkas, Madeline M. McGregor, Aishwarya Sritharan, Katherine Durham, Ivan Alekseichuk, Allison M. Letkiewicz, Vijay A. Mittal, David Pagliaccio, Nicholas B. Allen, Randy P. Auerbach, Stewart A. Shankman
Background Central to major depressive disorder (MDD) onset and maintenance is maladaptive self‐focused attention, which can be reliably indexed by greater: (a) usage of first‐person singular pronouns (e.g., I ) in natural language and (b) alpha oscillations in resting‐state EEG. Integrating these largely parallel bodies of research, the present study sought to explicate the associations between, and prospective predictive utility of, linguistic and neural indicators of self‐focused attention in adolescents with remitted MDD over 12 months. Methods At baseline, 126 adolescents (ages 13–18) with ( n = 66) and without ( n = 60) remitted MDD completed resting‐state EEG. Retrospective interviews determined the occurrence of major depressive episodes (MDEs) during the follow‐up period. A total of ~2.3 million messages were passively acquired from adolescents' smartphones, on which the proportion of first‐person singular pronouns was derived. Results During the 12 months, 29 (23.0%) participants developed an MDE (28 remitted MDD, 1 control). Cox regression showed that while greater usage of first‐person singular pronouns prior to MDE increased the risk for MDE (hazard ratio [HR] = 2.02, p < .001), greater resting‐state alpha power at baseline decreased the risk for MDE (HR = 0.78, p = .001). Moreover, greater alpha power predicted subsequent first‐person singular pronoun usage ( β = 0.17, p = .004). Mediation analysis indicated a marginal suppression effect (bootstrapped indirect effect p < .10), such that accounting for first‐person singular pronoun usage amplified the association between alpha power and MDE risk. Conclusions Findings highlight functionally distinct alpha mechanisms and provide support for smartphone‐based first‐person singular pronoun usage as a neurobehavioral risk factor and a potentially promising intervention target for adolescent MDD.
重度抑郁症(MDD)发病和维持的核心是不适应的自我集中注意力,这可以通过以下方式可靠地进行索引:(a)自然语言中第一人称单数代词的使用(例如,I)和(b)静息状态EEG的α振荡。整合这些基本平行的研究,本研究试图解释语言和神经指标之间的关联,以及在12个月的MDD缓解青少年中自我集中注意力的前瞻性预测效用。方法在基线时,126名(n = 66)和未(n = 60) MDD缓解的青少年(13-18岁)完成静息状态EEG。回顾性访谈确定随访期间重性抑郁发作(MDEs)的发生情况。从青少年智能手机被动获取的信息总数约为230万条,其中第一人称单数代词的比例来源于此。结果在12个月内,29名(23.0%)参与者发生MDE(28名缓解MDD, 1名对照组)。Cox回归显示,虽然在MDE之前更多地使用第一人称单数代词会增加MDE的风险(风险比[HR] = 2.02, p < 001),但基线时更大的静息状态alpha功率会降低MDE的风险(HR = 0.78, p = .001)。此外,更大的α功率预测随后的第一人称单数代词使用(β = 0.17, p = 0.004)。中介分析表明存在边际抑制效应(自举间接效应p <; .10),即第一人称单数代词的使用放大了alpha功率与MDE风险之间的关联。研究结果强调了功能上不同的alpha机制,并为智能手机第一人称单数代词的使用作为神经行为风险因素和青少年MDD潜在的有希望的干预目标提供了支持。
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引用次数: 0
Ambient heat and early childhood development: a cross-national analysis. 环境热与儿童早期发展:一项跨国分析。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-08 DOI: 10.1111/jcpp.70081
Jorge Cuartas,Lenin H Balza,Andrés Camacho,Nicolás Gómez-Parra
BACKGROUNDIncreasing evidence suggests that climate change, along with its cascading impacts on ecosystems, societies, and communities, has significant effects on both physical and mental health. However, less is known about how exposure to excessive heat early in life may influence the development of foundational skills that shape lifelong developmental trajectories. This study examined the effects of ambient heat on early childhood development across six countries, using geographic and time-stamped data on child development and ambient temperature.METHODSOur primary outcome is the Early Childhood Development Index. We used linear probability models with geographic and seasonality fixed effects to account for baseline climatic conditions, as well as other individual and contextual covariates to address potential selection bias. The sample comprised 19,607 children aged three and four from Georgia, The Gambia, Madagascar, Malawi, Sierra Leone, and the State of Palestine, all participants in Multiple Indicators Cluster Surveys collected between 2017 and 2020. We merged these data with temperature data from the ERA5-Land Monthly Aggregated Climate Dataset, calculating the mean monthly maximum temperature children experienced from birth to interview.RESULTSWe found that children exposed to average maximum temperatures above 32°C were less likely to be developmentally on track compared to those exposed to cooler temperatures, even after accounting for baseline average climatic conditions and other covariates. Domain-specific models indicate that these effects were most pronounced in literacy and numeracy skills. Subgroup analyses revealed that the negative impacts were particularly severe for children in economically disadvantaged households and urban areas, and for those lacking access to adequate water and sanitation.CONCLUSIONSThis study highlights the potential impact of excessive heat on early childhood development, emphasizing the need for policies and interventions that enhance preparedness, adaptation, and resilience to support human development in an rapidly warming world.
越来越多的证据表明,气候变化及其对生态系统、社会和社区的连锁影响对身心健康都有重大影响。然而,对于生命早期暴露于过度高温如何影响影响终身发展轨迹的基本技能的发展,人们知之甚少。这项研究利用儿童发育和环境温度的地理和时间戳数据,调查了六个国家的环境热量对儿童早期发育的影响。方法主要观察指标为儿童早期发育指数。我们使用具有地理和季节性固定效应的线性概率模型来解释基线气候条件,以及其他个体和上下文协变量来解决潜在的选择偏差。样本包括来自格鲁吉亚、冈比亚、马达加斯加、马拉维、塞拉利昂和巴勒斯坦国的19607名3至4岁儿童,他们都是2017年至2020年收集的多指标类集调查的参与者。我们将这些数据与ERA5-Land月度汇总气候数据集的温度数据合并,计算儿童从出生到访谈期间的月平均最高温度。结果我们发现,即使在考虑了基线平均气候条件和其他协变量之后,暴露在平均最高温度高于32°C的儿童比暴露在较低温度下的儿童更不可能发育正常。特定领域的模型表明,这些影响在读写和计算技能方面最为明显。分组分析显示,对经济条件不利的家庭和城市地区的儿童以及无法获得足够的水和卫生设施的儿童来说,负面影响尤其严重。本研究强调了过热对儿童早期发育的潜在影响,强调了加强准备、适应和恢复力的政策和干预措施的必要性,以支持人类在快速变暖的世界中的发展。
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引用次数: 0
A detailed investigation of anxiety disorders in children of clinically anxious parents: a population-based study. 临床焦虑父母的儿童焦虑症的详细调查:一项基于人群的研究。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-04 DOI: 10.1111/jcpp.70085
Sigrid Elfström,Susanne Wicks,Christina Dalman,Johan Åhlén
BACKGROUNDWe assessed the risk of anxiety disorders in children of clinically anxious parents, focusing on the influence of parent and child sex, parental care level, depressive comorbidity, and anxiety subtype, while controlling for socioeconomic factors and other parental psychiatric conditions.METHODSWe conducted a population-based study utilizing comprehensive healthcare data. A cohort of children (N = 516,134), born in 1998-2015 and residing in Stockholm, Sweden, was followed until they were diagnosed with anxiety, moved, or turned 18. The primary and secondary exposures were parental specified and unspecified anxiety diagnoses, respectively. The outcome was child specified anxiety diagnosis. Associations were estimated using hazard ratios (HRs) with 95% confidence intervals (CIs).RESULTSAmong exposed children, 4.3% were diagnosed with specified anxiety disorders, compared to 3.0% of unexposed (HR: 1.44, 95% CI: 1.38, 1.51). Adjustment for socioeconomic factors and other parental psychiatric disorders attenuated the risk (HR: 1.27, 95% CI: 1.21, 1.34). The risk was higher when parental anxiety was recorded in specialized psychiatric care (HR: 1.69, 95% CI: 1.60, 1.79) than in primary care (HR: 1.24, 95% CI: 1.17, 1.32). Maternal anxiety was linked to a higher risk (HR: 1.49, 95% CI: 1.41, 1.56) than paternal (HR: 1.31, 95% CI: 1.21, 1.42). Children were most likely to develop the same anxiety disorder as their parents, in cases of social anxiety, specific phobia, and panic disorder. Parental unspecified anxiety diagnoses were not associated with an increase in risk (HR: 1.02, 95% CI: 0.98, 1.07).CONCLUSIONSParental specified anxiety modestly increased the risk of child anxiety disorders. While the overall risk was lower than previously reported, it varied across diagnosis types and care levels.
背景:我们评估了临床焦虑父母的儿童焦虑障碍的风险,重点关注父母和儿童性别、父母护理水平、抑郁共病和焦虑亚型的影响,同时控制社会经济因素和其他父母精神状况。方法:我们利用综合医疗数据进行了一项基于人群的研究。一组儿童(N = 516,134),出生于1998-2015年,居住在瑞典斯德哥尔摩,被跟踪,直到他们被诊断出患有焦虑症、搬家或年满18岁。初次和二次暴露分别是父母指定的和未指定的焦虑诊断。结果是儿童特定的焦虑诊断。使用95%置信区间(ci)的风险比(hr)估计相关性。结果暴露儿童中,4.3%被诊断为特定焦虑症,而未暴露儿童的这一比例为3.0% (HR: 1.44, 95% CI: 1.38, 1.51)。社会经济因素和其他父母精神疾病的调整降低了风险(HR: 1.27, 95% CI: 1.21, 1.34)。在专门的精神科护理中记录父母焦虑的风险(HR: 1.69, 95% CI: 1.60, 1.79)高于初级保健(HR: 1.24, 95% CI: 1.17, 1.32)。与父亲(HR: 1.31, 95% CI: 1.21, 1.42)相比,母亲焦虑与更高的风险相关(HR: 1.49, 95% CI: 1.41, 1.56)。在社交焦虑、特定恐惧症和恐慌症的情况下,孩子们最有可能患上与父母相同的焦虑症。父母未明确的焦虑诊断与风险增加无关(HR: 1.02, 95% CI: 0.98, 1.07)。结论父母特异性焦虑会适度增加儿童焦虑障碍的风险。虽然总体风险低于之前的报道,但因诊断类型和护理水平而异。
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引用次数: 0
Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks. 急性厌食症患者神经丝光水平升高与白质体积和连接网络的改变有关。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-02 DOI: 10.1111/jcpp.70083
Inger Hellerhoff,Daniel Geisler,Fabio Bernardoni,Arne Doose,Friederike I Tam,David M Poitz,Nina Chotjewitz,Veit Roessner,Katja Akgün,Tjalf Ziemssen,Stefan Ehrlich
BACKGROUNDAnorexia nervosa (AN) is a severe eating disorder associated with drastic reductions in gray and white matter (WM) volume and structural connectivity alterations. However, the hypotheses regarding underlying mechanisms are inconclusive. The current study investigated the relationships of WM volume as well as WM network architecture with neurofilament light (NF-L), a marker of axonal damage.METHODSBlood samples and magnetic resonance imaging scans from 77 predominantly adolescent female participants with acute AN were used. Associations of WM volume with NF-L were tested using linear models. The relationship between NF-L and alterations in brain networks was evaluated using network-based statistic (NBS) models, which predicted connectivity associated with NF-L levels. Additionally, associations with clinical variables and leptin were tested. To test the specificity of the results, control analyses were conducted on 77 female healthy participants (HC).RESULTSWe found negative associations between NF-L concentrations and WM volume. NBS analyses identified seven components, where fractional anisotropy was positively associated with NF-L. In some components, mean connectivity was negatively associated with leptin concentrations. Mediation analyses suggested that the negative correlation of leptin and NF-L might be partially mediated by changes in WM microstructure. These effects were not observed in HC.CONCLUSIONSThe results suggest that WM volume reductions in acute AN might be related to axonal damage. The NBS results indicate, that the elevated fractional anisotropy previously found in AN might be related to damage processes leading to axonal swelling. All in all, the present study supports NF-L as a global blood marker for brain damage processes in acute AN.
神经性厌食症(AN)是一种严重的饮食失调,与灰质和白质(WM)体积急剧减少和结构连接改变有关。然而,关于潜在机制的假设尚无定论。本研究研究了WM体积和WM网络结构与神经丝光(NF-L)的关系,神经丝光是轴突损伤的标志。方法对77例以青春期女性为主的急性AN患者进行血样和磁共振成像扫描。使用线性模型检验WM体积与NF-L的关系。使用基于网络的统计(NBS)模型评估NF-L与脑网络变化之间的关系,该模型预测NF-L水平相关的连通性。此外,还测试了与临床变量和瘦素的关系。为了检验结果的特异性,对77名女性健康参与者(HC)进行了对照分析。结果NF-L浓度与WM体积呈负相关。NBS分析确定了7个成分,其中分数各向异性与NF-L呈正相关。在某些成分中,平均连通性与瘦素浓度呈负相关。中介分析表明,瘦素与NF-L的负相关可能部分介导了WM微观结构的改变。在HC中没有观察到这些效应。结论急性AN的WM体积减少可能与轴突损伤有关。NBS结果表明,先前在AN中发现的分数各向异性升高可能与导致轴突肿胀的损伤过程有关。总而言之,本研究支持NF-L作为急性AN脑损伤过程的全球血液标志物。
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引用次数: 0
Measurement congruence between record data and retrospective self-report measures of child maltreatment: do positive childhood experiences affect discrepancies? 记录数据与儿童虐待回顾性自我报告测量的一致性:积极的童年经历会影响差异吗?
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-11-28 DOI: 10.1111/jcpp.70080
Justin Russotti,Jennifer M Warmingham,Rachel Y Levin,Lauren Hutson,Hannah Swerbenski,Dante Cicchetti,Elizabeth D Handley
BACKGROUNDDiscrepancies between retrospective self-reports and official record data of child maltreatment (CM) are well-documented, yet few studies have examined how newer self-report instruments compare with record data or what factors influence inconsistencies across methods. This study addresses two primary aims: (1) to provide the first concordance estimates between prospective child protective services (CPS) records and the maltreatment and abuse chronology of exposure (MACE), a widely used retrospective CM assessment tool; and (2) to examine the influence of positive childhood experiences on discrepancies in CM assessment.METHODSWe utilize two maltreatment cohorts in which adults and adolescents with documented histories of CM and matched nonmaltreated controls were enrolled. Both cohorts included CM data from CPS records coded with the maltreatment classification system (MCS) and retrospective self-reports of CM and measures of positive childhood experiences. The cohorts vary in age at retrospective assessment (adults vs. adolescents), retrospective time lag (long vs. short), used different self-report measures (MACE vs. CTQ), and different methods for assessing positive experiences (explicit self-report vs. ratings of unconscious content). The rigorous dual-study design ensures findings are robust to study- and measurement-specific differences.RESULTSFindings revealed minimal agreement between MACE self-reports and MCS-coded CPS records for maltreatment occurring from ages 0-12. Discrepancies were primarily driven by retrospective reports of CM not documented in official records. Importantly, in both studies, individuals with more positive childhood experiences were less likely to self-report maltreatment (via MACE or CTQ) that was documented based on official records.CONCLUSIONSFindings suggest that positive childhood experiences may help facilitate resilience among CM survivors by influencing memory and appraisal of childhood events. Clinical interventions that explore autobiographical memories may be particularly effective in mitigating the psychopathology sequelae of maltreatment.
背景:关于儿童虐待的回顾性自我报告和官方记录数据之间的差异是有证可循的,但很少有研究调查了更新的自我报告工具与记录数据的比较,或者是什么因素影响了方法之间的不一致性。本研究有两个主要目的:(1)提供前瞻性儿童保护服务(CPS)记录与虐待和虐待暴露年表(MACE)之间的首次一致性估计,MACE是一种广泛使用的回顾性CM评估工具;(2)检验童年积极经历对CM评估差异的影响。方法:我们使用了两个虐待队列,其中有CM病史的成人和青少年以及匹配的未受虐待的对照组。两个队列都包括来自CPS记录的虐待分类系统(MCS)编码的CM数据,以及CM的回顾性自我报告和积极童年经历的测量。在回顾性评估的年龄(成人vs青少年)、回顾性时间滞后(长vs短)、使用不同的自我报告测量(MACE vs. CTQ)和评估积极体验的不同方法(显性自我报告vs.无意识内容评分)方面,队列各不相同。严格的双研究设计确保了研究结果对研究和测量特定差异的稳健性。结果发现MACE自我报告与mcs编码的CPS记录在0-12岁发生的虐待行为之间的一致性很小。差异主要是由未在官方记录中记录的CM回顾性报告引起的。重要的是,在这两项研究中,有更积极童年经历的个体不太可能自我报告虐待(通过MACE或CTQ),这是根据官方记录记录的。结论积极的童年经历可能通过影响童年事件的记忆和评价来促进CM幸存者的恢复能力。探索自传式记忆的临床干预可能在减轻虐待的精神病理后遗症方面特别有效。
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引用次数: 0
Editorial: Probing the limits of youth participation in the translational science of neurodivergence 社论:探讨青年参与神经分化转化科学的限制
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-11-22 DOI: 10.1111/jcpp.70082
Edmund J. S. Sonuga-Barke

Unblocking the translational path between science and practice is a major priority for the field of child psychology and psychiatry. I have recently argued that key to this, going forward, will be our ability to come up with new framings of old challenges that allow us to develop new theories, hypotheses, methods and interpretations. I called this creative seeking-out of different perspectives, paradigm flipping. In this editorial, I argue that incorporating young people with neurodevelopmental and mental health conditions into the heart of our science, as co-investigators and not just advisors, can promote effective paradigm flipping in a way that can invigorate our science. I illustrate this by highlighting a recent programme of research, Regulating Emotion and Strengthening Adolescent Resilience (RE-STAR), which demonstrated not only that such a radical participatory approach is possible but that it can change the way we do science in demonstrably positive ways.

打通科学与实践之间的转化之路是儿童心理学和精神病学领域的首要任务。我最近认为,未来实现这一目标的关键在于,我们有能力对旧的挑战提出新的框架,从而使我们能够发展新的理论、假设、方法和解释。我把这称为创造性的寻找——从不同的角度出发,范式翻转。在这篇社论中,我认为,将有神经发育和心理健康问题的年轻人纳入我们科学的核心,作为合作研究者而不仅仅是顾问,可以促进有效的范式翻转,从而为我们的科学注入活力。为了说明这一点,我强调了最近的一项研究计划,即调节情绪和加强青少年恢复力(RE - STAR),该计划不仅证明了这种激进的参与式方法是可能的,而且还证明了它可以以明显积极的方式改变我们从事科学研究的方式。
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引用次数: 0
The intentional and spontaneous social motor synchrony of pre-school autistic children: Evidence from fNIRS hyperscanning and machine learning. 学龄前自闭症儿童有意的和自发的社会运动同步:来自近红外光谱超扫描和机器学习的证据。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-11-18 DOI: 10.1111/jcpp.70079
Kaiyun Li,Caiyan Zheng,Yue Yang,Bang Du,Yaou Zhao,Yuehui Chen,Junqi Liu,Jiaxin Cai,Wenjing Cheng,Kezhen Lv,Liu Chen,Fanlu Jia,Shuhua Su,Wanzhi Tang
BACKGROUNDSocial motor synchrony is critical for successful social interaction. It remains unclear whether autistic children exhibit distinct differences in intentional versus spontaneous social motor synchrony, as well as what underlying interpersonal neural synchrony (INS) mechanisms drive these potential differences.METHODFifty-four children (28 autistic) completed intentional (a delayed and synchronous imitation tasks in EX1) and spontaneous (a rhythmic hand-clapping task in EX2) tasks with an adult. Brain signals were collected by a portable multichannel fNIRS device and classified by GaussianNB machine learning approach.RESULTSCompared with non-autistic children, autistic children showed: (1) significantly lower behavioral synchrony across both two experiments; (2) reduced activation in the right temporoparietal junction (r-TPJ, CH18) during Ex1, with no significant group differences in activation observed across all 20 fNIRS channels during Ex2; (3) significantly lower INS values in task-specific brain regions, that left inferior parietal lobule (l-IPL, CH3) in the delayed imitation condition in EX1; left inferior frontal gyrus (l-IFG, CH2), l-IPL (CH9), and r-TPJ (CH18) in the synchronous imitation condition in Ex1, and in the IPL (CH8, CH10-14) and r-TPJ (CH18) in Ex2. The GaussianNB model successfully discriminated between autistic and non-autistic children using task-related INS values, with classification accuracy varying by task condition, reaching 55.56% in the delayed imitation condition of EX1, 57.41% in the time-lag analysis condition of EX1, 64.81% in the synchronous imitation condition of EX1, and 74.07% in Ex2. Notably, the SHAP toolkit identified key channels driving group distinction-and these channels fully overlapped with the statistically significant INS channels identified in the analyses.CONCLUSIONSAutistic children exhibit differences in both intentional and spontaneous social motor synchrony, and these differences are linked to reduced INS in key social cognitive brain regions (IFG, IPL, TPJ). This research advances understanding of social functioning variations in autistic individuals and provides a foundational foundation for developing INS-based diagnostic tools.
社会运动同步对于成功的社会互动至关重要。目前尚不清楚自闭症儿童是否在有意和自发的社会运动同步中表现出明显的差异,以及潜在的人际神经同步(INS)机制驱动这些潜在的差异。方法54名儿童(28名自闭症儿童)在成人陪同下完成有意(EX1的延迟和同步模仿任务)和自发(EX2的节奏鼓掌任务)任务。脑信号由便携式多通道fNIRS设备采集,并采用高斯annb机器学习方法进行分类。结果与非自闭症儿童相比,自闭症儿童的行为同步性显著低于非自闭症儿童(1);(2) Ex1期间右颞顶叶交界处(r-TPJ, CH18)的激活减少,Ex2期间所有20个fNIRS通道的激活没有显著组间差异;(3) EX1延迟模仿条件下左下顶叶(l-IPL, CH3)任务特异性脑区INS值显著降低;Ex1同步模仿条件下左额下回(l-IFG, CH2)、l-IPL (CH9)和r-TPJ (CH18), Ex2同步模仿条件下IPL (CH8, CH10-14)和r-TPJ (CH18)的变化。高斯annb模型利用任务相关INS值成功区分了自闭症儿童和非自闭症儿童,分类准确率随任务条件的不同而不同,在EX1的延迟模仿条件下达到55.56%,在EX1的时滞分析条件下达到57.41%,在EX1的同步模仿条件下达到64.81%,在Ex2的同步模仿条件下达到74.07%。值得注意的是,SHAP工具包确定了驱动群体差异的关键渠道,这些渠道与分析中确定的具有统计意义的INS渠道完全重叠。结论自闭症儿童在有意和自发社会运动同步方面存在差异,这些差异与IFG、IPL、TPJ等关键社会认知脑区INS减少有关。本研究促进了对自闭症个体社会功能差异的理解,并为开发基于ins的诊断工具提供了基础。
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引用次数: 0
The stability of the Autism Diagnostic Observation Schedule-2 in children aged 14-36 months with elevated likelihood for autism. 自闭症诊断观察表2在14-36月龄高自闭症可能性儿童中的稳定性。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-11-16 DOI: 10.1111/jcpp.70078
Sarah Schaubroeck,Ellen Demurie,Jannath Begum-Ali,Sven Bölte,Sofie Boterberg,Jan Buitelaar,Tony Charman,Terje Falck-Ytter,Sabine Hunnius,Mark H Johnson,Emily Jones,Iris Oosterling,Greg Pasco,Mirjam Pijl,Carlijn Van den Boomen,Petra Warreyn,Herbert Roeyers
BACKGROUNDThis study investigated the stability of Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) classifications in a cohort of 304 siblings at elevated likelihood for autism (EL-siblings).METHODSADOS-2 assessments were conducted at 14, 24 and 36 months, with Clinical Best Estimate (CBE) autism diagnoses determined at 36 months.RESULTSOur findings indicate that while some children have stable ADOS-2 classifications from early on, a significant proportion of the children show inconsistent classifications over time. The overall stability of ADOS-2 autism spectrum classifications increased from 14 to 36 months and agreement with CBE autism clinical diagnosis was moderate and increased with age.CONCLUSIONSCaution is warranted when interpreting individual ADOS-2 results, as they should always complement, and can never replace, a comprehensive clinical evaluation. These findings highlight the importance of continued follow-up beyond 14 months in young EL-children, a group for whom early assessment may be both feasible and beneficial and emphasises the need to integrate multiple assessment measures and multiple informants for accurate early autism identification.
本研究调查了304名自闭症高可能性兄弟姐妹(el -sibling)队列中自闭症诊断观察表第二版(ADOS-2)分类的稳定性。方法在14、24、36个月时进行sados -2评估,36个月时进行临床最佳估计(CBE)孤独症诊断。结果我们的研究结果表明,虽然一些儿童从早期开始就有稳定的ADOS-2分类,但随着时间的推移,很大一部分儿童的分类不一致。从14个月到36个月,ADOS-2自闭症谱系分类的总体稳定性增加,与CBE自闭症临床诊断的一致性中等,并随着年龄的增长而增加。结论:在解释个体的ADOS-2结果时需要谨慎,因为它们应该总是补充,而不能取代全面的临床评估。这些发现强调了对el儿童持续随访超过14个月的重要性,这一群体的早期评估可能既可行又有益,并强调需要整合多种评估措施和多种信息来源,以准确识别早期自闭症。
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引用次数: 0
Vocabulary development in autistic children: a network growth analysis. 自闭症儿童词汇发展:网络成长分析。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-11-12 DOI: 10.1111/jcpp.70076
Eileen Haebig,Stanley West,Christopher R Cox
BACKGROUNDAutistic children are typically late to develop their expressive vocabulary, but little is known about their early word learning process. This study compared three network growth models on their ability to account for the trajectories of expressive vocabulary acquisition in autistic and non-autistic children.METHODSWe studied expressive vocabularies using item-level data from a child vocabulary checklist (n = 721 records from young autistic children; n = 2,166 records from non-autistic toddlers). We estimated vocabulary growth trajectories for autistic and non-autistic children and assessed the goodness of fit of three models of vocabulary growth, with varying sensitivity to the structure of the environment and the learner's existing vocabulary knowledge. To do so, we first computed word-level acquisition norms that indicate the vocabulary size at which individual words tend to be learned by each group. Then we evaluated how well network growth models, based on natural language co-occurrence structure and word associations, accounted for variance in the autistic and non-autistic acquisition norms.RESULTSOur word-level vocabulary size of acquisition norms closely aligned with age of acquisition data, indicating their utility when age of acquisition norms cannot be derived for neurodivergent populations. Furthermore, we extended key observations and demonstrated that the growth models explained similar amounts of variance in each group. Both groups are biased to learn words that have many connections to words that have been previously learned; however, even after accounting for this learning influence, autistic and non-autistic vocabulary growth trajectories receive an added boost in learning when words are connected to many other words in the learning environment, indicating a similar learning profile.CONCLUSIONSBoth groups preferentially acquire new words by leveraging the semantic structure in the learning environment, indicating an overlap in theoretical accounts of vocabulary growth.
自闭症儿童通常发展表达性词汇的时间较晚,但人们对他们早期的词汇学习过程知之甚少。本研究比较了三种网络增长模型对自闭症儿童和非自闭症儿童表达性词汇习得轨迹的解释能力。方法采用儿童词汇表(n = 721例自闭症儿童和2166例非自闭症幼儿)中的项目级数据研究表达性词汇。我们估计了自闭症儿童和非自闭症儿童的词汇增长轨迹,并评估了三种词汇增长模型的拟合优度,这些模型对环境结构和学习者现有词汇知识的敏感度不同。为此,我们首先计算了单词水平习得规范,该规范表明每个组倾向于学习单个单词的词汇量。然后,我们评估了基于自然语言共现结构和单词关联的网络增长模型如何很好地解释自闭症和非自闭症习得规范的差异。结果我们的习得规范的词汇量与习得年龄数据密切相关,表明当神经分化人群无法获得习得规范的年龄时,它们的效用。此外,我们扩展了关键观察结果,并证明了增长模型解释了每个组中相似的方差量。两组人都倾向于学习与之前学过的单词有很多联系的单词;然而,即使考虑到这种学习影响,当单词与学习环境中的许多其他单词相关联时,自闭症和非自闭症的词汇增长轨迹在学习中也会得到额外的促进,这表明了类似的学习情况。结论两组学生都倾向于利用学习环境中的语义结构来习得新词,这表明词汇增长的理论解释存在重叠。
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引用次数: 0
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Journal of Child Psychology and Psychiatry
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