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Indirect genetic effects of siblings 兄弟姐妹的间接遗传效应
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-13 DOI: 10.1111/jcpp.70130
Mathias Valstad, Espen Moen Eilertsen, Ziada Ayorech, Rosa Cheesman, Perline Demange, Nikolai Haahjem Eftedal, Alexandra Havdahl, Eivind Ystrom
Background Within‐family designs are increasingly used to decompose genotype–trait associations into direct and indirect genetic effects. Many such designs, including trio designs or within‐sibship designs, assume an absence of sibling indirect genetic effects. Methods We expand two well‐known molecular genetic within‐family designs, one variance component (genome‐based restricted maximum likelihood) and one trait‐based (structural equation modeling with polygenic indices), to estimate sibling indirect genetic effects, along with direct genetic effects. We link the Norwegian Mother, Father, and Child Cohort Study (MoBa) to Norway's national education database to model genetic effects on national standardized testing results at ages 10, 13, and 14, and on parent‐rated attention‐deficit hyperactivity disorder (ADHD) symptoms at ages 3 and 8 in up to 15,971 genotyped and phenotyped siblings. Results Estimates of direct and indirect genetic effects from the genome‐based restricted maximum likelihood and the structural equation modeling with polygenic indices approaches converge, albeit with the variance component estimates typically an order of magnitude greater than the trait‐based estimates. We observe no indirect genetic effects of siblings on educational performance at any age, and only slightly negative indirect genetic effects of siblings on ADHD symptoms at age 3. We argue that the latter effect might reflect parental contrasting ratings. Conclusions The results suggest that within‐family models of educational performance are unlikely to be drastically biased by an assumption of absent sibling indirect genetic effects. Combining trait‐based analyses with variance component analyses can benefit understanding of indirect genetic effects, especially when the effects are not specific to a particular mechanism.
家族内设计越来越多地用于将基因型-性状关联分解为直接和间接遗传效应。许多这样的设计,包括三人设计或兄弟姐妹内设计,假设没有兄弟姐妹间接遗传效应。方法我们扩展了两种已知的家族内分子遗传设计,一种是方差成分(基于基因组的限制最大似然),另一种是基于性状的(多基因指数结构方程建模),以估计兄弟姐妹的间接遗传效应和直接遗传效应。我们将挪威母亲、父亲和儿童队列研究(MoBa)与挪威国家教育数据库联系起来,以模拟遗传对10岁、13岁和14岁国家标准化测试结果的影响,以及对多达15,971名基因型和表型的兄弟姐妹在3岁和8岁时父母评定的注意力缺陷多动障碍(ADHD)症状的影响。结果基于基因组的限制最大似然和基于多基因指数的结构方程建模方法对直接和间接遗传效应的估计是收敛的,尽管方差分量估计通常比基于性状的估计大一个数量级。我们没有观察到兄弟姐妹在任何年龄对教育表现的间接遗传影响,只有轻微负的间接遗传影响兄弟姐妹在3岁时ADHD症状。我们认为,后一种影响可能反映了父母对比评级。结论:研究结果表明,家庭内部的教育表现模型不太可能因为没有兄弟姐妹间接遗传效应的假设而出现严重偏差。将基于性状的分析与方差成分分析相结合,有助于理解间接遗传效应,特别是当影响不是特定于特定机制时。
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引用次数: 0
Longitudinal associations between violence exposure and adolescent conduct problems in a high‐adversity, South African setting 南非高逆境环境中暴力暴露与青少年行为问题的纵向关联
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-11 DOI: 10.1111/jcpp.70132
Susan Swingler, Qing Han, Alexis E. Cullen, Stefani du Toit, Sarah Skeen, Jane Barlow, Mark Tomlinson
Background Violence exposure is a well‐established risk factor for adolescent conduct problems, yet longitudinal research in high‐adversity, low‐ and middle‐income countries (LMICs) remains limited. This study investigated whether early adolescent violence exposure predicts concurrent and longer‐term conduct problems, and explored potential bidirectional associations and sex differences in a peri‐urban South African community with high rates of poverty and violence. Methods Data were drawn from the Thula Sana birth cohort ( n = 357; 51.5% female), a longitudinal intervention study in Khayelitsha, South Africa. Adolescents were assessed at early (ages 12–14) and late adolescence (ages 16–19). Violence exposure was measured using adolescent self‐report. Conduct problems were measured using adolescent and caregiver report in early adolescence and adolescent self‐report in late adolescence. Multiple linear regressions tested cross‐sectional associations, and cross‐lagged panel models examined longitudinal and bidirectional associations, adjusting for contextual adversity and intervention status. Missing data were addressed using multiple imputation, and findings were confirmed through sensitivity analyses. Results Violence exposure was associated with higher concurrent conduct problems in early adolescence (β = .15–.19, p < .01) and predicted higher conduct problems in late adolescence (β = .12–.14, p < .05). The reverse pathway, from conduct problems to subsequent violence exposure, was not significant (β = .08–.11, p > .05). Interaction analyses did not provide evidence that associations differed by sex. Conclusions Violence exposure in early adolescence represents a prospective risk factor for conduct problems in a high‐adversity South African setting. Findings highlight the importance of early, contextually grounded violence prevention and the need for further research to test sex‐specific pathways and inform the development of gender‐responsive intervention strategies.
暴力暴露是青少年行为问题的一个公认的危险因素,但在高逆境、低收入和中等收入国家(LMICs)的纵向研究仍然有限。本研究调查了青少年早期暴力暴露是否能预测并发的和长期的行为问题,并探讨了在一个贫困和暴力发生率高的南非城市周边社区中潜在的双向关联和性别差异。方法数据来自南非Khayelitsha的Thula Sana出生队列(n = 357, 51.5%为女性),这是一项纵向干预研究。青少年在青春期早期(12-14岁)和青春期晚期(16-19岁)进行评估。使用青少年自我报告测量暴力暴露。行为问题在青少年早期和青少年晚期分别使用青少年和照顾者报告和青少年自我报告进行测量。多元线性回归检验了横截面关联,交叉滞后面板模型检验了纵向和双向关联,调整了环境逆境和干预状态。缺失的数据使用多重输入处理,并通过敏感性分析确认结果。结果暴力暴露与青少年早期较高的并发行为问题相关(β = 0.15 -)。19, p < .01),并预测青春期后期较高的行为问题(β = .12 -)。14, p < .05)。相反的途径,从行为问题到随后的暴力暴露,不显著(β = .08 -)。11, p > .05)。相互作用分析没有提供证据表明这种关联因性别而异。结论:在南非高逆境环境中,青少年早期暴力暴露是行为问题的潜在危险因素。研究结果强调了早期、基于情境的暴力预防的重要性,以及进一步研究以测试性别特异性途径和为制定性别敏感干预策略提供信息的必要性。
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引用次数: 0
The randomized controlled trial Fast Track multilevel intervention for children with early-emerging conduct problems breaks intergenerational transmission of violence across three generations. 对早期出现行为问题的儿童进行快速通道多层次干预的随机对照试验打破了暴力在三代之间的代际传递。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-11 DOI: 10.1111/jcpp.70133
Laura Gorla, W Andrew Rothenberg, Jennifer Godwin

Background: Domestic violence mechanisms are frequently transmitted across generations, representing a global issue demanding particular attention. This study investigates the intergenerational transmission of intimate partner violence (IPV) and parent-to-child violence (PCV) and whether participating in a multilevel preventive intervention (Fast Track) breaks this transmission.

Methods: In high-risk elementary schools located in the United States, children considered at high risk for aggressive behavior based on teachers' and parents' screen scores were assigned to either a 10-year intervention or a control group based on their school. The Fast Track trial was registered at clinicaltrials.gov (NCT01653535) and was focused on parenting practices and children's intrapersonal, interpersonal, and academic skills. From the original 891 children, 374 participants with children aged less than 18 years (n = 191 intervention group, n = 183 control group) reported at age 34 their experience with domestic violence and their children's psychological adjustment.

Results: The intergenerational mediating pathway from high IPV in the first generation to high PCV in the second generation to greater total mental health difficulties in the third generation was statistically significant in the control group but not in the intervention group.

Conclusions: IPV was intergenerationally transmitted by influencing PCV, with a negative effect on the third generation's mental health. Nevertheless, participation in the Fast Track intervention disrupted this cycle. These findings suggest the importance of policies to support preventive childhood interventions.

背景:家庭暴力机制经常代代相传,是一个需要特别关注的全球性问题。本研究探讨了亲密伴侣暴力(IPV)和父母对儿童暴力(PCV)的代际传播,以及参与多层次预防干预(快速通道)是否能打破这种传播。方法:在美国的高危小学中,根据教师和家长的屏幕评分被认为具有攻击行为高风险的儿童根据他们的学校被分配到10年干预组或对照组。快速通道试验已在clinicaltrials.gov注册(NCT01653535),重点关注育儿实践和儿童的人际关系、人际关系和学术技能。从最初的891名儿童中,374名18岁以下儿童的参与者(干预组n = 191,对照组n = 183)在34岁时报告了他们的家庭暴力经历和孩子的心理适应情况。结果:从第一代高PCV到第二代高PCV再到第三代总心理健康困难的代际中介通路在对照组中有统计学意义,而在干预组中无统计学意义。结论:IPV通过影响PCV代际传播,对第三代心理健康有负面影响。然而,快速通道干预的参与打破了这一循环。这些发现表明,支持儿童预防性干预措施的政策非常重要。
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引用次数: 0
Effects of parent-child interaction therapy dosage on child and parent outcomes: differentiating child-directed interaction and parent-directed interaction session impacts in child welfare-involved families. 亲子互动治疗剂量对儿童和家长结局的影响:区分儿童导向互动和家长导向互动对儿童福利家庭的影响。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-03 DOI: 10.1111/jcpp.70106
Xiaolan Liao, Julia P Ruggiero, David E Bard, Adon F G Rosen, Elizabeth A Skowron

Background: Parent-child interaction therapy (PCIT) improves parenting and child behavior, yet little is known about how dosage of its two phases, warm relationship building focused child-directed interaction (CDI) sessions and safe, effective discipline skills-focused parent-directed interaction (PDI) sessions, contributes to outcomes, particularly in child welfare-involved families. Understanding these dose-response patterns can clarify the pathways through which PCIT produces change.

Methods: In a sample of 204 child welfare families with young children, we examined the dose-response relationship between each PCIT phase and key intervention outcomes of positive and negative parenting skills and disruptive child behavior problems. We also used sequential mediation models to test time-ordered intervention dosage effects (i.e., number of CDI sessions completed and subsequent number of PDI sessions completed) on the parent and child outcomes.

Results: Sequential mediation models showed that the PCIT intervention exerted significant indirect effects on increased positive parenting skills and decreased negative parenting behaviors and child behavior problems through higher dosage of relationship-enhancing CDI sessions followed by higher dosage of safe discipline-focused PDI sessions. Further, CDI dosage interacted with PDI dosage to predict greater gains in positive parenting skills outcomes.

Conclusions: These results contribute new insights into the pathways through which PCIT shapes outcomes in a sample of child welfare-involved families. Findings also highlight the significant unique contribution that limit-setting-oriented PDI, a relatively understudied phase of PCIT, plays in enhancing positive parenting skills and mitigating child behavior problems.

背景:亲子互动治疗(PCIT)可以改善父母教养和儿童行为,但对于其两个阶段的剂量,即以建立温暖关系为重点的儿童指导互动(CDI)课程和安全有效的以纪律技能为重点的父母指导互动(PDI)课程,如何促进结果,特别是在涉及儿童福利的家庭中,知之甚少。了解这些剂量-反应模式可以阐明PCIT产生变化的途径。方法:以204个有幼儿的儿童福利家庭为样本,考察各阶段PCIT与积极、消极父母教养技能和破坏性儿童行为问题关键干预结果的量效关系。我们还使用顺序中介模型来测试时间顺序的干预剂量效应(即完成CDI治疗的次数和随后完成PDI治疗的次数)对父母和儿童结局的影响。结果:序贯中介模型显示,PCIT干预通过高剂量的关系强化型PDI课程后高剂量的安全纪律型PDI课程,对提高积极育儿技能、减少消极育儿行为和儿童行为问题具有显著的间接影响。此外,CDI剂量与PDI剂量相互作用,预测积极育儿技能结果的更大收益。结论:这些结果为PCIT在涉及儿童福利的家庭样本中形成结果的途径提供了新的见解。研究结果还强调了以限制为导向的PDI在提高积极育儿技能和减轻儿童行为问题方面的重要独特贡献,这一阶段的研究相对较少。
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引用次数: 0
Psycho-social factors associated with disagreement between prospective and retrospective measures of childhood maltreatment. 与儿童虐待的前瞻性和回顾性测量不一致相关的心理社会因素。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-31 DOI: 10.1111/jcpp.70129
Oonagh Coleman,Jessie R Baldwin,Louise Arseneault,Helen L Fisher,Terrie E Moffitt,Andrea Danese
BACKGROUNDProspective and retrospective measures of childhood maltreatment often identify different individuals and are differentially associated with psychopathology. This study examines psycho-social factors that may explain discrepancies between these measures.METHODSData were drawn from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2,232 children born in 1994-1995 across England and Wales and followed to age 18 (93% retention). Childhood maltreatment was assessed through: (a) prospective assessments from caregivers, researchers, and clinicians at ages 5-12, and (b) retrospective self-reports at age 18 using the Childhood Trauma Questionnaire (for maltreatment occurring up to age 12). For the analyses, we focused on participants identified as maltreated from either measure (n = 290) and an a-priori selected array of potential explanatory variables assessed between ages 5-18. We conducted two sets of analyses: comparing individuals with only prospectively identified maltreatment to those identified by both prospective and retrospective measures to understand why some participants did not retrospectively report or recall maltreatment; and comparing individuals with only retrospective self-reports to those identified by both prospective and retrospective measures to understand why maltreatment had not been detected prospectively.RESULTSParticipants in the prospective-only group reported greater social support over the life course and lower psychopathology at age 18 compared to those identified through both prospective and retrospective measures. Individuals in the retrospective-only group had higher socioeconomic status, higher self-reported adult involvement at age 12, and less exposure to domestic violence compared to those identified through both prospective and retrospective measures.CONCLUSIONSOur findings suggest that perceptions of social support and better mental health may buffer retrospective recall of childhood maltreatment in those with prospective measures. Furthermore, more positive family functioning and socioeconomic factors may hamper prospective detection of childhood maltreatment in those who retrospectively report it.
背景:儿童虐待的前瞻性和回顾性测量通常识别不同的个体,并且与精神病理有不同的关联。本研究探讨了可能解释这些测量之间差异的心理社会因素。方法数据来自环境风险纵向双胞胎研究,这是一项具有全国代表性的出生队列,包括英格兰和威尔士1994-1995年出生的2232名儿童,随访至18岁(93%保留率)。儿童虐待通过以下方式进行评估:(a) 5-12岁时护理人员、研究人员和临床医生的前瞻性评估,以及(b) 18岁时使用儿童创伤问卷的回顾性自我报告(针对12岁前发生的虐待)。在分析中,我们将重点放在从任一测量(n = 290)和先验选择的一系列潜在解释变量中确定为受虐待的参与者,评估年龄在5-18岁之间。我们进行了两组分析:将仅前瞻性识别的虐待个体与前瞻性和回顾性方法识别的个体进行比较,以了解为什么一些参与者没有回顾性报告或回忆虐待;并将只有回顾性自我报告的个体与通过前瞻性和回顾性测量确定的个体进行比较,以了解为什么虐待没有被前瞻性地发现。结果:与通过前瞻性和回顾性测量确定的参与者相比,前瞻性组的参与者在18岁时报告了更多的社会支持和更低的精神病理。与通过前瞻性和回顾性测量确定的个体相比,仅回顾性组的个体在12岁时具有更高的社会经济地位,更高的自我报告成人参与,并且较少接触家庭暴力。结论社会支持认知和良好的心理健康状况可以缓冲具有前瞻性措施的儿童虐待的回顾性回忆。此外,更积极的家庭功能和社会经济因素可能会阻碍那些回顾性报告儿童虐待的人的前瞻性发现。
{"title":"Psycho-social factors associated with disagreement between prospective and retrospective measures of childhood maltreatment.","authors":"Oonagh Coleman,Jessie R Baldwin,Louise Arseneault,Helen L Fisher,Terrie E Moffitt,Andrea Danese","doi":"10.1111/jcpp.70129","DOIUrl":"https://doi.org/10.1111/jcpp.70129","url":null,"abstract":"BACKGROUNDProspective and retrospective measures of childhood maltreatment often identify different individuals and are differentially associated with psychopathology. This study examines psycho-social factors that may explain discrepancies between these measures.METHODSData were drawn from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2,232 children born in 1994-1995 across England and Wales and followed to age 18 (93% retention). Childhood maltreatment was assessed through: (a) prospective assessments from caregivers, researchers, and clinicians at ages 5-12, and (b) retrospective self-reports at age 18 using the Childhood Trauma Questionnaire (for maltreatment occurring up to age 12). For the analyses, we focused on participants identified as maltreated from either measure (n = 290) and an a-priori selected array of potential explanatory variables assessed between ages 5-18. We conducted two sets of analyses: comparing individuals with only prospectively identified maltreatment to those identified by both prospective and retrospective measures to understand why some participants did not retrospectively report or recall maltreatment; and comparing individuals with only retrospective self-reports to those identified by both prospective and retrospective measures to understand why maltreatment had not been detected prospectively.RESULTSParticipants in the prospective-only group reported greater social support over the life course and lower psychopathology at age 18 compared to those identified through both prospective and retrospective measures. Individuals in the retrospective-only group had higher socioeconomic status, higher self-reported adult involvement at age 12, and less exposure to domestic violence compared to those identified through both prospective and retrospective measures.CONCLUSIONSOur findings suggest that perceptions of social support and better mental health may buffer retrospective recall of childhood maltreatment in those with prospective measures. Furthermore, more positive family functioning and socioeconomic factors may hamper prospective detection of childhood maltreatment in those who retrospectively report it.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"82 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resource profiles and suicide attempts in youth with disabilities. 资源简介和残疾青年的自杀企图。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-30 DOI: 10.1111/jcpp.70122
Minhae Cho,C Hyung Keun Park,Misa Kayama,Sujin Seo,Jungjoon Ihm
BACKGROUNDThe issue of suicide among youth with disabilities transitioning into adulthood is a serious public health issue. In navigating this transition, youth with disabilities encounter unique obstacles that require careful consideration and support. This study aims to identify resource profiles among youth with disabilities and their association with suicide attempts in early adulthood.METHODSUsing data from the National Longitudinal Study of Adolescent Health (Add Health), this study included 1,472 youth with disabilities. A Gaussian finite mixture model (GMM) was employed to identify underlying distinct groups of youth with disabilities based on their available resources.RESULTSFour latent classes emerged: (1) Socioeconomically Advantaged and Socially Supportive (37%); (2) Socioeconomically Advantaged, but Socially Isolated (28%); (3) Socioeconomically Disadvantaged and Socially Isolated (20%); and (4) Socioeconomically Disadvantaged, but Socially Supportive (15%). Results from the generalized linear mixed model (GLMM) considering a longer transition period into adulthood up to age 32 and relevant time-varying factors found that youth in Socioeconomically Advantaged, but Socially Isolated and Socioeconomically Disadvantaged, but Socially Supportive had a significantly lower likelihood of suicide attempts compared to those in Socioeconomically Advantaged and Socially Supportive. The likelihood of suicide attempts for youth with learning disabilities was significantly lower than for those with physical disabilities, while a history of suicide attempts in adolescence and experience with a death by suicide of family members or friends increased the odds of suicide attempts.CONCLUSIONSThe study highlights the heterogeneity of youth with disabilities, demonstrating how demographic characteristics, disability-specific needs, family and school environments and social support systems intersect to influence suicide attempt prevention.
背景:成年期残疾青年的自杀问题是一个严重的公共卫生问题。在过渡过程中,残疾青年遇到了独特的障碍,需要认真考虑和支持。本研究旨在确定残疾青年的资源概况及其与成年早期自杀企图的关系。方法使用国家青少年健康纵向研究(Add Health)的数据,本研究包括1472名残疾青少年。采用高斯有限混合模型(GMM)根据现有资源识别潜在的不同残疾青年群体。结果出现了四个潜在阶层:(1)社会经济优势和社会支持(37%);(2)社会经济条件优越,但社会孤立(28%);(3)社会经济弱势和社会孤立(20%);(4)在社会经济上处于劣势,但在社会上支持(15%)。从广义线性混合模型(GLMM)的结果来看,考虑到32岁前较长的成年过渡期和相关的时变因素,社会经济条件优越但社会孤立的青年和社会经济条件不利但社会支持的青年的自杀企图可能性显著低于社会经济条件优越和社会支持的青年。有学习障碍的青少年自杀的可能性明显低于有身体残疾的青少年,而青少年时期有自杀企图的历史以及有家人或朋友自杀的经历会增加自杀企图的几率。该研究强调了残疾青年的异质性,展示了人口特征、残疾特定需求、家庭和学校环境以及社会支持系统如何相互影响自杀企图预防。
{"title":"Resource profiles and suicide attempts in youth with disabilities.","authors":"Minhae Cho,C Hyung Keun Park,Misa Kayama,Sujin Seo,Jungjoon Ihm","doi":"10.1111/jcpp.70122","DOIUrl":"https://doi.org/10.1111/jcpp.70122","url":null,"abstract":"BACKGROUNDThe issue of suicide among youth with disabilities transitioning into adulthood is a serious public health issue. In navigating this transition, youth with disabilities encounter unique obstacles that require careful consideration and support. This study aims to identify resource profiles among youth with disabilities and their association with suicide attempts in early adulthood.METHODSUsing data from the National Longitudinal Study of Adolescent Health (Add Health), this study included 1,472 youth with disabilities. A Gaussian finite mixture model (GMM) was employed to identify underlying distinct groups of youth with disabilities based on their available resources.RESULTSFour latent classes emerged: (1) Socioeconomically Advantaged and Socially Supportive (37%); (2) Socioeconomically Advantaged, but Socially Isolated (28%); (3) Socioeconomically Disadvantaged and Socially Isolated (20%); and (4) Socioeconomically Disadvantaged, but Socially Supportive (15%). Results from the generalized linear mixed model (GLMM) considering a longer transition period into adulthood up to age 32 and relevant time-varying factors found that youth in Socioeconomically Advantaged, but Socially Isolated and Socioeconomically Disadvantaged, but Socially Supportive had a significantly lower likelihood of suicide attempts compared to those in Socioeconomically Advantaged and Socially Supportive. The likelihood of suicide attempts for youth with learning disabilities was significantly lower than for those with physical disabilities, while a history of suicide attempts in adolescence and experience with a death by suicide of family members or friends increased the odds of suicide attempts.CONCLUSIONSThe study highlights the heterogeneity of youth with disabilities, demonstrating how demographic characteristics, disability-specific needs, family and school environments and social support systems intersect to influence suicide attempt prevention.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"30 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analyzing transdiagnostic internalizing symptoms in a global sample of trauma‐exposed children using pooled individual participant data: a latent transition analysis 使用汇总的个体参与者数据分析全球创伤暴露儿童样本中的跨诊断内化症状:潜在转变分析
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-29 DOI: 10.1111/jcpp.70113
Yaara Sadeh, Leila Graham, Marthe R. Egberts, Lonneke I.M. Lenferink, Nancy Kassam‐Adams
Background Children often experience both posttraumatic stress (PTS) and depression after potentially traumatic events (PTEs). Latent class analyses (LCAs) identify subgroups with different co‐occurring symptoms, but little is known about what predicts transitions between these symptom classes over time. Analyzing these transitions could reveal factors that influence the shift to classes with fewer internalizing symptoms. Methods Using harmonized individual participant data ( n = 787) from nine studies (United States, United Kingdom, Australia, and Switzerland) included in the Prospective studies of Acute Child Trauma and Recovery Data Archive (PACT/R), internalizing symptom classes (using PTS and depression items) were identified using LCAs for T1 (0–2 months posttrauma) and T2 (3–15 months posttrauma) separately. Latent transition analysis was used to examine predictors of transitions across symptom classes over time. Included predictors were age, gender, minority status, and trauma type. Results Five classes were identified at both time points: ‘low internalizing’ class (T1: 20%; T2: 40%), ‘low PTS/moderate‐high depression’ class (T1: 20%; T2: 27%), ‘moderate internalizing’ class (T1: 25%; T2: 12%), ‘moderate PTS/high depression’ class (T1: 17%, T2: 14%), and ‘high internalizing’ class (T1: 16%, T2: 6%). ‘Low internalizing’ was the most common and stable response (87% stayed in this class). At both time points, 40% of all children were classified into either a ‘low PTS/moderate‐high depression’ class or a ‘moderate PTS/high depression’ class. Children belonging to minority groups in their country of residence and children exposed to interpersonal PTEs were less likely to transition from the ‘high internalizing’ class to lower symptom classes. Conclusions Most children show low PTS and depression symptoms after PTEs. When symptoms do develop, they usually involve both high depression and PTS, rather than high PTS with low depression. This underscores the importance of assessing both conditions and developing interventions that target multiple disorders. Minority children exposed to interpersonal trauma require special focus in research and treatment.
背景:儿童在潜在创伤事件(pte)后经常经历创伤后应激(PTS)和抑郁。潜在类别分析(lca)确定了具有不同共发生症状的亚组,但对于如何预测这些症状类别之间随时间的转变知之甚少。分析这些转变可以揭示影响向内化症状较少的班级转变的因素。方法使用纳入急性儿童创伤与恢复数据档案前瞻性研究(PACT/R)的9项研究(美国、英国、澳大利亚和瑞士)的统一个体参与者数据(n = 787),分别在T1(创伤后0-2个月)和T2(创伤后3-15个月)使用LCAs识别内化症状分类(使用PTS和抑郁项目)。使用潜在转变分析来检查跨症状类别随时间转变的预测因子。预测因素包括年龄、性别、少数民族身份和创伤类型。结果在两个时间点确定了五个类别:“低内化”类别(T1: 20%; T2: 40%),“低PTS/中高抑郁”类别(T1: 20%; T2: 27%),“中度内化”类别(T1: 25%; T2: 12%),“中度PTS/高抑郁”类别(T1: 17%, T2: 14%)和“高内化”类别(T1: 16%, T2: 6%)。“低内化”是最常见和最稳定的反应(87%的人留在这个班)。在这两个时间点,40%的儿童被分为“低PTS/中重度抑郁”或“中度PTS/重度抑郁”。在其居住国属于少数群体的儿童和暴露于人际pte的儿童不太可能从“高内化”类别过渡到较低的症状类别。结论多数患儿在pte后表现为低PTS和抑郁症状。当症状确实出现时,通常包括高抑郁和PTS,而不是高PTS伴低抑郁。这强调了评估病症和制定针对多种疾病的干预措施的重要性。遭受人际创伤的少数民族儿童需要特别关注研究和治疗。
{"title":"Analyzing transdiagnostic internalizing symptoms in a global sample of trauma‐exposed children using pooled individual participant data: a latent transition analysis","authors":"Yaara Sadeh, Leila Graham, Marthe R. Egberts, Lonneke I.M. Lenferink, Nancy Kassam‐Adams","doi":"10.1111/jcpp.70113","DOIUrl":"https://doi.org/10.1111/jcpp.70113","url":null,"abstract":"Background Children often experience both posttraumatic stress (PTS) and depression after potentially traumatic events (PTEs). Latent class analyses (LCAs) identify subgroups with different co‐occurring symptoms, but little is known about what predicts transitions between these symptom classes over time. Analyzing these transitions could reveal factors that influence the shift to classes with fewer internalizing symptoms. Methods Using harmonized individual participant data ( <jats:italic>n</jats:italic> = 787) from nine studies (United States, United Kingdom, Australia, and Switzerland) included in the Prospective studies of Acute Child Trauma and Recovery Data Archive (PACT/R), internalizing symptom classes (using PTS and depression items) were identified using LCAs for T1 (0–2 months posttrauma) and T2 (3–15 months posttrauma) separately. Latent transition analysis was used to examine predictors of transitions across symptom classes over time. Included predictors were age, gender, minority status, and trauma type. Results Five classes were identified at both time points: ‘low internalizing’ class (T1: 20%; T2: 40%), ‘low PTS/moderate‐high depression’ class (T1: 20%; T2: 27%), ‘moderate internalizing’ class (T1: 25%; T2: 12%), ‘moderate PTS/high depression’ class (T1: 17%, T2: 14%), and ‘high internalizing’ class (T1: 16%, T2: 6%). ‘Low internalizing’ was the most common and stable response (87% stayed in this class). At both time points, 40% of all children were classified into either a ‘low PTS/moderate‐high depression’ class or a ‘moderate PTS/high depression’ class. Children belonging to minority groups in their country of residence and children exposed to interpersonal PTEs were less likely to transition from the ‘high internalizing’ class to lower symptom classes. Conclusions Most children show low PTS and depression symptoms after PTEs. When symptoms do develop, they usually involve both high depression and PTS, rather than high PTS with low depression. This underscores the importance of assessing both conditions and developing interventions that target multiple disorders. Minority children exposed to interpersonal trauma require special focus in research and treatment.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"180 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relative strengths in daily living skills among autistic individuals and individuals with related developmental conditions who have co-occurring intellectual disability. 自闭症患者和伴随智力残疾的相关发育障碍患者在日常生活技能方面的相对优势。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-28 DOI: 10.1111/jcpp.70124
Elaine B Clarke,Catherine Lord,Vanessa Hus Bal
BACKGROUNDStrong daily living skills (DLS) are associated with positive outcomes. Prior studies have documented intellectual quotient (IQ)-DLS discrepancies in autistic individuals with average or higher cognitive abilities. Little work in this area includes individuals with co-occurring intellectual disability (ID) or examines IQ-DLS discrepancies at the level of DLS subdomains (i.e., Personal, Domestic, and Community skills). This study examined trajectories of IQ-DLS discrepancies from ages 2-25 in autistic individuals with ID.METHODSA total of 127 individuals from a well-characterized longitudinal cohort with verbal IQ < 70 at age 9 were included. IQ-DLS discrepancy scores were calculated by subtracting DLS AEs from nonverbal mental age (NVMA) estimates. Group-based trajectory modeling identified IQ-DLS discrepancy trajectory groups for the DLS domain and Personal, Domestic, and Community subdomains. One-way ANOVA and chi-square analyses were used to compare trajectory groups on demographic and phenotypic characteristics.RESULTSTwo DLS domain discrepancy trajectory groups emerged: IQ > DLS (cognitive abilities exceeded DLS) and IQ < DLS (DLS exceeded cognitive abilities); most participants (78%) were in the IQ > DLS group. An additional group, IQ = DLS (cognitive abilities and DLS were commensurate), emerged in each of the DLS subdomains, for a total of three trajectory groups. Within DLS subdomains, approximately 80% of participants were in either the IQ = DLS or the IQ < DLS trajectory group. In other words, examining scores at the DLS domain-level indicated most participants had cognitive abilities that exceeded DLS, but subdomain scores indicated most participants had DLS that equaled or exceeded cognitive abilities.CONCLUSIONSThese results challenge the notion that autism is usually associated with weaknesses in DLS compared to IQ. At the subdomain level, 80% of participants had DLS commensurate with or stronger than their cognitive abilities, indicating domain-level scores may obscure important variability in daily functioning. This work highlights the importance of including autistic individuals with ID in research; patterns observed in samples without ID may not be generalizable.
强大的日常生活技能(DLS)与积极的结果相关。先前的研究已经证明了具有平均或更高认知能力的自闭症患者的智商(IQ)-DLS差异。这一领域的研究很少包括同时发生智力残疾(ID)的个体,或在DLS子领域(即个人、家庭和社区技能)水平上检查智商-DLS差异。本研究考察了2-25岁孤独症患者的智商- dls差异轨迹。方法选取纵向队列中127名言语智商DLS组(认知能力超过DLS)和智商DLS组。另外一个组,IQ = DLS(认知能力和DLS是相称的),出现在每个DLS子域,总共有三个轨迹组。在DLS子域内,大约80%的参与者处于IQ = DLS或IQ < DLS轨迹组。换句话说,在DLS领域水平上的得分表明大多数参与者的认知能力超过了DLS,但子领域得分表明大多数参与者的DLS等于或超过了认知能力。结论:这些结果挑战了自闭症通常与DLS比IQ弱有关的观念。在子领域水平,80%的参与者的DLS与他们的认知能力相当或更强,这表明领域水平得分可能掩盖了日常功能的重要变异性。这项工作强调了将自闭症患者纳入研究的重要性;在没有ID的样本中观察到的模式可能无法推广。
{"title":"Relative strengths in daily living skills among autistic individuals and individuals with related developmental conditions who have co-occurring intellectual disability.","authors":"Elaine B Clarke,Catherine Lord,Vanessa Hus Bal","doi":"10.1111/jcpp.70124","DOIUrl":"https://doi.org/10.1111/jcpp.70124","url":null,"abstract":"BACKGROUNDStrong daily living skills (DLS) are associated with positive outcomes. Prior studies have documented intellectual quotient (IQ)-DLS discrepancies in autistic individuals with average or higher cognitive abilities. Little work in this area includes individuals with co-occurring intellectual disability (ID) or examines IQ-DLS discrepancies at the level of DLS subdomains (i.e., Personal, Domestic, and Community skills). This study examined trajectories of IQ-DLS discrepancies from ages 2-25 in autistic individuals with ID.METHODSA total of 127 individuals from a well-characterized longitudinal cohort with verbal IQ < 70 at age 9 were included. IQ-DLS discrepancy scores were calculated by subtracting DLS AEs from nonverbal mental age (NVMA) estimates. Group-based trajectory modeling identified IQ-DLS discrepancy trajectory groups for the DLS domain and Personal, Domestic, and Community subdomains. One-way ANOVA and chi-square analyses were used to compare trajectory groups on demographic and phenotypic characteristics.RESULTSTwo DLS domain discrepancy trajectory groups emerged: IQ > DLS (cognitive abilities exceeded DLS) and IQ < DLS (DLS exceeded cognitive abilities); most participants (78%) were in the IQ > DLS group. An additional group, IQ = DLS (cognitive abilities and DLS were commensurate), emerged in each of the DLS subdomains, for a total of three trajectory groups. Within DLS subdomains, approximately 80% of participants were in either the IQ = DLS or the IQ < DLS trajectory group. In other words, examining scores at the DLS domain-level indicated most participants had cognitive abilities that exceeded DLS, but subdomain scores indicated most participants had DLS that equaled or exceeded cognitive abilities.CONCLUSIONSThese results challenge the notion that autism is usually associated with weaknesses in DLS compared to IQ. At the subdomain level, 80% of participants had DLS commensurate with or stronger than their cognitive abilities, indicating domain-level scores may obscure important variability in daily functioning. This work highlights the importance of including autistic individuals with ID in research; patterns observed in samples without ID may not be generalizable.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"7 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unequal educational outcomes for children with similar early childhood vocabulary but different socioeconomic circumstances. 具有相似幼儿词汇但不同社会经济环境的儿童的教育结果不平等。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-26 DOI: 10.1111/jcpp.70117
Emma Thornton,Danielle Matthews,Praveetha Patalay,Colin Bannard
BACKGROUNDIn a purely meritocratic society, educational outcomes would reflect ability and only ability. Vocabulary size is a common measure of cognitive ability that predicts educational outcomes but is confounded with socioeconomic circumstances (SEC).METHODSIn preregistered analyses of the nationally representative UK Millennium Cohort Study data (N = 15,576), we used a series of multiple linear and logistic regression analyses to investigate the predictive value of age-5 vocabulary for age-16 educational outcomes and assess whether socioeconomic circumstance moderated this relation.RESULTSWe show that age-5 vocabulary strongly predicted age-16 educational attainment, even after adjusting for both SEC and caregiver vocabulary (OR = 1.62, 95% CIs = [1.52; 1.72]; β = .22, 95% CIs = [0.19; 0.24]). SEC also predicts educational attainment (OR = 2.05, 95% CIs = [1.92; 2.19]), and modifies the association between vocabulary and educational attainment, whereby a larger vocabulary was most advantageous for those in middle SEC groups (interaction term OR = 1.09 [1.03; 1.15]).CONCLUSIONSEarly child vocabulary is a strong predictor of children's educational outcomes - even when controlling for proxy measures of the home environment and genetics. Nonetheless, children who enter school with strong vocabulary skills but disadvantaged socioeconomic circumstances still have only about a 50/50 chance of gaining gateway qualifications at age 16.
在一个纯粹的精英社会中,教育结果将反映能力,而且只反映能力。词汇量是一种常见的认知能力测量方法,可以预测教育成果,但与社会经济环境相混淆。方法对具有全国代表性的英国千禧年队列研究数据(N = 15,576)进行预登记分析,我们使用一系列多元线性和逻辑回归分析来研究5岁词汇量对16岁教育成果的预测价值,并评估社会经济环境是否会调节这种关系。结果5岁的词汇量对16岁的受教育程度有很强的预测作用,即使在调整了SEC和照顾者词汇量之后(OR = 1.62, 95% ci = [1.52; 1.72]; β =。22, 95% ci = [0.19];0.24])。SEC还能预测受教育程度(OR = 2.05, 95% ci =[1.92; 2.19]),并修正了词汇量与受教育程度之间的关系,即中等SEC组的词汇量越大越有利(交互项OR = 1.09[1.03; 1.15])。结论:幼儿词汇是儿童教育成果的一个强有力的预测指标,即使在控制家庭环境和遗传的替代措施时也是如此。尽管如此,那些入学时词汇能力很强但社会经济环境不利的孩子,在16岁时获得入门资格的机会仍然只有50%。
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引用次数: 0
Improving child mental health and learning outcomes and reducing stigma and discrimination in conflict setting: findings from a cluster randomized controlled trial of a classroom-based psychosocial intervention in rural primary schools in Afghanistan. 改善儿童心理健康和学习成果,减少冲突环境下的污名化和歧视:阿富汗农村小学课堂社会心理干预整群随机对照试验结果。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-25 DOI: 10.1111/jcpp.70125
Jean-Francois Trani,Yiqi Zhu,Saria Bechara,Shuya Yin,Parul Bakhshi,Ian Kaplan,Ramkrishna K Singh,Mohammed A Modaber,Hashim Rawab,Madelyn Yoo,Kim Thuy Seelinger,Ganesh G Babulal,Ramesh Raghavan
BACKGROUNDConflict and crises have long-lasting and dramatic consequences on the mental health of children. We aimed to investigate the effectiveness of a psychosocial intervention on child mental health in Afghanistan.METHODSA two-arm cluster-randomized controlled trial was conducted in 83 rural primary schools within three provinces of Afghanistan. Children in Grades 3-6, their teachers, and one adult family member were enrolled. Schools were randomly assigned (1:1) to one of two groups: a treatment group composed of entire classes receiving a week-long classroom-based teacher-and-child psychosocial training, a one-day family engagement component, and a community-based system dynamics workshop; and a control group. Primary outcomes were anxiety, depression, life skills, self-efficacy, and resilience of the child. Secondary outcomes included reading and mathematical literacy, mathematical problem-solving, and school-based discrimination and stigma. This trial is registered with the International Standard Randomized Controlled Trials Number registry (ISRCTN83632872).RESULTSIn June 2021, 40 schools and n = 2,262 children were randomly assigned to the intervention group and 43 schools and n = 2,277 children to the control group. Preintervention survey started October 2, 2021 (first batch) and April 10th, 2023 (second batch). After a minimum of 4-month intervention, a postintervention survey took place. No treatment effects were found on anxiety, depression, resilience, self-efficacy, life skills, or stigma. Effects were found for academic outcomes and school-based discrimination. Shorter interventions displayed reductions in depression, anxiety, stigma, and discrimination, and an increase in life skills. Additional analyses showed significant effects on several outcomes for boys, on a few outcomes for girls, and in areas where the governmental did not disrupt the process.CONCLUSIONSClassroom-based interventions delivered by trained field-based educational staff can effectively promote child mental health, social-emotional skills, and academic outcomes, and reduce stigma and discrimination among subgroups of children in conflict and crisis settings and have viable potential for scalability.
冲突和危机对儿童的心理健康产生长期和严重的影响。我们的目的是调查心理社会干预对阿富汗儿童心理健康的有效性。方法在阿富汗3个省的83所农村小学进行双组随机对照试验。3-6年级的孩子、他们的老师和一名成人家庭成员被招募。学校被随机分配(1:1)到两组中的一组:治疗组由整个班级组成,接受为期一周的基于课堂的教师和儿童心理社会培训,一天的家庭参与部分和以社区为基础的系统动力学研讨会;还有一个对照组。主要结果是焦虑、抑郁、生活技能、自我效能和儿童的适应能力。次要结果包括阅读和数学素养,数学问题解决,以及基于学校的歧视和耻辱。该试验已在国际标准随机对照试验号注册中心注册(ISRCTN83632872)。结果2021年6月,将40所学校、n = 2262名儿童随机分为干预组,43所学校、n = 2277名儿童分为对照组。干预前调查于2021年10月2日(第一批)和2023年4月10日(第二批)开始。干预至少4个月后,进行干预后调查。在焦虑、抑郁、恢复力、自我效能、生活技能或耻辱感方面没有发现治疗效果。研究发现,学业成绩和校本歧视都有影响。较短的干预显示出抑郁、焦虑、耻辱和歧视的减少,以及生活技能的提高。进一步的分析显示,对男孩的几个结果,对女孩的几个结果,以及在政府没有干扰这一过程的地区,都有显著的影响。结论由训练有素的实地教育人员提供的基于课堂的干预措施可以有效促进儿童心理健康、社会情感技能和学业成绩,并减少冲突和危机环境中儿童亚群体的污名和歧视,具有可扩展性。
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引用次数: 0
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Journal of Child Psychology and Psychiatry
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