Pub Date : 2024-04-01eCollection Date: 2024-05-01DOI: 10.1093/nsr/nwae129
Hong Liu
{"title":"A study that redefines the concept of a well-known orchid-pollinator attraction strategy.","authors":"Hong Liu","doi":"10.1093/nsr/nwae129","DOIUrl":"10.1093/nsr/nwae129","url":null,"abstract":"","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"11 5","pages":"nwae129"},"PeriodicalIF":20.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-18eCollection Date: 2024-05-01DOI: 10.1093/nsr/nwae084
He Zhu
{"title":"China's top 10 breakthroughs in science and technology in 2023.","authors":"He Zhu","doi":"10.1093/nsr/nwae084","DOIUrl":"https://doi.org/10.1093/nsr/nwae084","url":null,"abstract":"","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"11 5","pages":"nwae084"},"PeriodicalIF":20.6,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04eCollection Date: 2024-04-01DOI: 10.1093/nsr/nwae078
Guocheng Jia
{"title":"Facile synthesis of transition metal complexes with five coplanar metal-carbon σ-bonds.","authors":"Guocheng Jia","doi":"10.1093/nsr/nwae078","DOIUrl":"https://doi.org/10.1093/nsr/nwae078","url":null,"abstract":"","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"11 4","pages":"nwae078"},"PeriodicalIF":20.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11044960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-26eCollection Date: 2024-03-01DOI: 10.1093/nsr/nwae064
Fritz E Kühn
{"title":"Exploration of chromene-based BioAIEgens.","authors":"Fritz E Kühn","doi":"10.1093/nsr/nwae064","DOIUrl":"10.1093/nsr/nwae064","url":null,"abstract":"","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"11 3","pages":"nwae064"},"PeriodicalIF":20.6,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23eCollection Date: 2024-03-01DOI: 10.1093/nsr/nwae067
Lianbin Zhang, Peng Wang
{"title":"Accelerated water harvesting from vapor via a bio-inspired hydrogel pattern.","authors":"Lianbin Zhang, Peng Wang","doi":"10.1093/nsr/nwae067","DOIUrl":"10.1093/nsr/nwae067","url":null,"abstract":"","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"11 3","pages":"nwae067"},"PeriodicalIF":20.6,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30eCollection Date: 2024-02-01DOI: 10.1093/nsr/nwae024
Fu-Chun Zhang, Hai-Zhou Lu, Xin-Cheng Xie
{"title":"The preface: Interplay of topological and magnetic orders in the Mn-Bi-Te family.","authors":"Fu-Chun Zhang, Hai-Zhou Lu, Xin-Cheng Xie","doi":"10.1093/nsr/nwae024","DOIUrl":"https://doi.org/10.1093/nsr/nwae024","url":null,"abstract":"","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"11 2","pages":"nwae024"},"PeriodicalIF":20.6,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meeting the challenges of invasive alien species","authors":"Weijie Zhao","doi":"10.1093/nsr/nwae017","DOIUrl":"https://doi.org/10.1093/nsr/nwae017","url":null,"abstract":"Here we report the Assessment Report on Invasive Alien Species and their Control released by IPBES, and the status of IAS in China.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"178 1","pages":""},"PeriodicalIF":20.6,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139464074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziyan Liao, Jie Jiang, Wei Wu, Jiaqi Shi, Yanfang Wang, Yuejun Yao, Tao Sheng, Feng Liu, Wei Liu, Peng Zhao, Feifei Lv, Jie Sun, Hongjun Li, Zhen Gu
The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T cell proliferation in lymph nodes. This scaffold gathers the function of loading, delivery, activation, and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) (PLGA) by a microfluidic technique with the modification of T cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model, and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.
{"title":"Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor","authors":"Ziyan Liao, Jie Jiang, Wei Wu, Jiaqi Shi, Yanfang Wang, Yuejun Yao, Tao Sheng, Feng Liu, Wei Liu, Peng Zhao, Feifei Lv, Jie Sun, Hongjun Li, Zhen Gu","doi":"10.1093/nsr/nwae018","DOIUrl":"https://doi.org/10.1093/nsr/nwae018","url":null,"abstract":"The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T cell proliferation in lymph nodes. This scaffold gathers the function of loading, delivery, activation, and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) (PLGA) by a microfluidic technique with the modification of T cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model, and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"30 1","pages":""},"PeriodicalIF":20.6,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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