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Bridging art and science
IF 21.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-20 DOI: 10.1038/s41556-024-01587-5
Sabrya Carim
Ahna Skop is a geneticist and artist at the University of Wisconsin–Madison, USA. Ahna’s lab studies the assembly and function of mammalian midbody and midbody remnant, which are assembled at the end of mitosis. Ahna also leans into her passion for scientific art to engage the public. We were fascinated to hear Ahna’s thoughts on open questions and challenges in the field and to learn about her passion of marrying science and art.
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引用次数: 0
Misshapen chromosomes in check by mechanics 机械控制畸形染色体
IF 21.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-18 DOI: 10.1038/s41556-024-01573-x
Joana C. Macedo, Maria M. da Silva, Elsa Logarinho
Errors in chromosome segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies.
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引用次数: 0
Worrying through the ECM
IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01579-5
Daryl J. V. David
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引用次数: 0
Cu in cancer metabolism
IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01578-6
Zhe Wang
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引用次数: 0
Regulating chromatin assembly
IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01581-x
Sabrya Carim
{"title":"Regulating chromatin assembly","authors":"Sabrya Carim","doi":"10.1038/s41556-024-01581-x","DOIUrl":"10.1038/s41556-024-01581-x","url":null,"abstract":"","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2013-2013"},"PeriodicalIF":17.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making stronger T cells
IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01577-7
Stylianos Lefkopoulos
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引用次数: 0
Women in Autophagy: an initiative to promote gender parity in science
IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-02 DOI: 10.1038/s41556-024-01566-w
Mericka McCabe, Patricia Boya, Ruey-Hwa Chen, Charleen T. Chu, Maria Isabel Colombo, Laura Delgui, Eeva-Liisa Eskelinen, Maho Hamasaki, Malene Hansen, Congcong He, Marja Jäättelä, Adi Kimchi, Claudine Kraft, Mondira Kundu, Alicia Melendez, Sophie Pattingre, Tassula Proikas-Cezanne, Salwa Sebti, Anna Katharina Simon, Anne Simonsen, Sharon A. Tooze, Maria Ines Vaccaro, Xiaochen Wang, Eileen White, Yan Zhao, Ana Maria Cuervo
Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in Autophagy network promote the careers of these underrepresented groups with a range of free, year-round scientific, mentoring and networking activities for all scientists.
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引用次数: 0
Author Correction: Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum
IF 21.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-12-02 DOI: 10.1038/s41556-024-01585-7
Yang Yang, Luis A. Valencia, Chih-Hao Lu, Melissa L. Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C. Wu, Bianxiao Cui

Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-024-01511-x, published online 17 September 2024.

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引用次数: 0
The enhancer module of Integrator controls cell identity and early neural fate commitment Integrator的增强子模块控制细胞特性和早期神经命运承诺
IF 21.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-11-26 DOI: 10.1038/s41556-024-01556-y
Yingjie Zhang, Connor M. Hill, Kelsey A. Leach, Luca Grillini, Sandra Deliard, Sarah R. Offley, Martina Gatto, Francis Picone, Avery Zucco, Alessandro Gardini

Lineage-specific transcription factors operate as master orchestrators of developmental processes by activating select cis-regulatory enhancers and proximal promoters. Direct DNA binding of transcription factors ultimately drives context-specific recruitment of the basal transcriptional machinery that comprises RNA polymerase II (RNAPII) and a host of polymerase-associated multiprotein complexes, including the metazoan-specific Integrator complex. Integrator is primarily known to modulate RNAPII processivity and to surveil RNA integrity across coding genes. Here we describe an enhancer module of Integrator that directs cell fate specification by promoting epigenetic changes and transcription factor binding at neural enhancers. Depletion of Integrator’s INTS10 subunit upends neural traits and derails cells towards mesenchymal identity. Commissioning of neural enhancers relies on Integrator’s enhancer module, which stabilizes SOX2 binding at chromatin upon exit from pluripotency. We propose that Integrator is a functional bridge between enhancers and promoters and a main driver of early development, providing new insight into a growing family of neurodevelopmental syndromes.

品系特异性转录因子通过激活选定的顺式调节增强子和近端启动子，成为发育过程的主协调者。转录因子与 DNA 的直接结合最终会驱动基础转录机制的特异性招募，基础转录机制包括 RNA 聚合酶 II（RNAPII）和大量与聚合酶相关的多蛋白复合物，其中包括类囊动物特有的 Integrator 复合物。据了解，Integrator 主要负责调节 RNAPII 的过程活性，并监控整个编码基因中 RNA 的完整性。在这里，我们描述了Integrator的一个增强子模块，它通过促进神经增强子的表观遗传变化和转录因子结合来指导细胞命运的规范化。缺失Integrator的INTS10亚基会破坏神经特征，并使细胞向间充质身份脱轨。神经增强子的调试依赖于Integrator的增强子模块，它能在细胞脱离多能性后稳定SOX2与染色质的结合。我们认为，Integrator 是增强子和启动子之间的功能性桥梁，也是早期发育的主要驱动力，它为日益增多的神经发育综合征家族提供了新的见解。
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引用次数: 0
FMRP gains mitochondrial fission control FMRP 获得线粒体裂变控制权
IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology
Pub Date : 2024-11-15 DOI: 10.1038/s41556-024-01567-9
Carissa L. Sirois, Soraya O. Sandoval, Xinyu Zhao
Mitochondrial fission and fusion are crucial for neurons. The RNA-binding protein FMRP regulates mitochondrial dynamics, including fusion and trafficking in neurons. A study now identifies a mechanism by which FMRP regulates mitochondrial fission.
线粒体的分裂和融合对神经元至关重要。RNA 结合蛋白 FMRP 可调节线粒体的动力学，包括神经元中的融合和贩运。现在，一项研究确定了FMRP调节线粒体裂变的机制。
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引用次数: 0
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