Three new isochroman derivatives, penicitrisochromans A-C (1-3), together with 25 known polyketides were isolated from the marine-derived fungus Penicillium citrinum PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of 3 were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, ω-hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant Staphylococcus aureus with MIC values of 32, 16 and 4 µg/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against Candida albicans NCPF3153 and Cryptococcus neoformans ATCC90112 with the respective MIC values of 16 and 64 µg/mL.
从海洋源真菌柠檬青霉 PSU-MF100 中分离出了三种新的异色素衍生物--青霉色素 A-C （1-3），以及 25 种已知的多酮类化合物。通过大量光谱分析阐明了它们的结构。通过比旋和电子圆二色性（ECD）数据与已知共代谢物的比旋和电子圆二色性数据进行比较，确定了 1 和 2 的绝对构型，而 3 的绝对构型则是根据 ECD 计算和生物合成考虑确定的。在分离出的多酮类化合物中，ω-羟基大黄素、青霉蒽素 A 和大黄素这三种已知的蒽醌衍生物对耐甲氧西林金黄色葡萄球菌具有中等到较强的抗菌活性，其 MIC 值分别为 32、16 和 4 µg/mL。在抗真菌活性方面，两种已知的苯并吡喃酮类化合物，即 coniochaetones A 和 C，对白色念珠菌 NCPF3153 和新型隐球菌 ATCC90112 表现出中等程度的抗真菌活性，其 MIC 值分别为 16 和 64 微克/毫升。
{"title":"Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100","authors":"Panthong Thamsiri , Vatcharin Rukachaisirikul , Souwalak Phongpaichit , Sita Preedanon , Jariya Sakayaroj , Chatchai Muanprasat , Sarinya Hadsadee , Siriporn Jungsuttiwong","doi":"10.1080/14786419.2024.2416515","DOIUrl":"10.1080/14786419.2024.2416515","url":null,"abstract":"<div><div>Three new isochroman derivatives, penicitrisochromans A-C (<strong>1</strong>-<strong>3</strong>), together with 25 known polyketides were isolated from the marine-derived fungus <em>Penicillium citrinum</em> PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of <strong>1</strong> and <strong>2</strong> were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of <strong>3</strong> were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, <em>ω</em>-hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant <em>Staphylococcus aureus</em> with MIC values of 32, 16 and 4 <em>µ</em>g/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against <em>Candida albicans</em> NCPF3153 and <em>Cryptococcus neoformans</em> ATCC90112 with the respective MIC values of 16 and 64 <em>µ</em>g/mL.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 635-641"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study compared the triterpenoid ingredients, polysaccharide, protein, amino acid, and volatile components of PC. The PC was treated with traditional sweating (TST), steaming sweating for 1 to 4 h (SS1h-SS4h, Δ = 1 h) and non-sweating (NS). The results showed the content of six triterpenoids (1.03 mg/g), water-soluble protein (0.33 mg/g) and total triterpenoid (3.81 mg/g) were the highest in NS; the content of alkali-soluble polysaccharide (51.96 mg/g) was the highest in SS1h; the content of crude protein (16.18 mg/g) and total amino acid (53.07 mg/g) were highest in TST. Moreover, the predominant volatile component of SS1h was hexanal, SS2h-SS4h and TST were Linalool, NS was D-limonene. Ulteriorly, the correlation analysis showed antioxidant effect of PC may be related to the content of alkali-soluble polysaccharide, Furan-2-pentyl, and 2-Octenal, PCA result indicated the score of SS1h-treated PC was the highest. This study could provide a new solution for the industrial production of PC.
该研究比较了 PC 的三萜类成分、多糖、蛋白质、氨基酸和挥发性成分。PC 经传统发汗（TST）、蒸煮发汗 1 至 4 小时（SS1h-SS4h，Δ = 1 小时）和不发汗（NS）处理。结果表明，六种三萜类化合物（1.03 毫克/克）、水溶性蛋白质（0.33 毫克/克）和总三萜类化合物（3.81 毫克/克）的含量在 NS 中最高；碱溶性多糖（51.96 毫克/克）的含量在 SS1h 中最高；粗蛋白（16.18 毫克/克）和总氨基酸（53.07 毫克/克）的含量在 TST 中最高。此外，SS1h 的主要挥发性成分是己醛，SS2h-SS4h 和 TST 的主要挥发性成分是芳樟醇，NS 的主要挥发性成分是 D-柠檬烯。此外，相关分析表明 PC 的抗氧化效果可能与碱溶性多糖、呋喃-2-戊基和 2-辛烯醛的含量有关，PCA 结果表明 SS1h 处理的 PC 得分最高。这项研究可为 PC 的工业化生产提供新的解决方案。
{"title":"The effects of different processing treatments to active ingredients, nutrients, volatile components and antioxidant activity in Poria cocos wolf","authors":"Chuqian Gao , Miaofen Chen , Xiang Wei , Jianguo Zeng , Hongqi Xie","doi":"10.1080/14786419.2024.2421905","DOIUrl":"10.1080/14786419.2024.2421905","url":null,"abstract":"<div><div>The study compared the triterpenoid ingredients, polysaccharide, protein, amino acid, and volatile components of PC. The PC was treated with traditional sweating (TST), steaming sweating for 1 to 4 h (SS1h-SS4h, <em>Δ</em> = 1 h) and non-sweating (NS). The results showed the content of six triterpenoids (1.03 mg/g), water-soluble protein (0.33 mg/g) and total triterpenoid (3.81 mg/g) were the highest in NS; the content of alkali-soluble polysaccharide (51.96 mg/g) was the highest in SS1h; the content of crude protein (16.18 mg/g) and total amino acid (53.07 mg/g) were highest in TST. Moreover, the predominant volatile component of SS1h was hexanal, SS2h-SS4h and TST were Linalool, NS was D-limonene. Ulteriorly, the correlation analysis showed antioxidant effect of PC may be related to the content of alkali-soluble polysaccharide, Furan-2-pentyl, and 2-Octenal, PCA result indicated the score of SS1h-treated PC was the highest. This study could provide a new solution for the industrial production of PC.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 666-674"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The essential oils (EOs) of Cymbopogon schoenanthus (L.) Spreng. collected from Ghardaïa Province were analyzed for their chemical composition by GC-MS analysis. The results showed fifty-one identified compounds representing 94.34% of the whole EOs, with β-eudesmol (11.35%) and α-elemol (10.84%) as major compounds. The TAC, DPPH, and FRAP antioxidant activities of the EOs were moderate, while an important inhibition of 63.54 ± 2.41% was obtained for the β-carotene bleaching assay. The results of the antibacterial activity show that gentamicin had an inhibition zone of 21.66 ± 0.57 mm while Bacillus cereus was the most sensitive species (inhibition zone of 20.75 ± 0.50 mm). The wound-healing activity results showed contraction percentages on the 20th day of 99.35 ± 0.12%, which was similar to the positive control 1% allantoin (98.33 ± 0.17%). Our results show that C.schoenanthus is a source of many bioactive compounds with well-known antioxidant, antibacterial and wound-healing properties.
{"title":"Chemical composition and biological activities of essential oils from Cymbopogon schoenanthus (L.) Spreng.: a Saharan plant from Ghardaïa region (Algeria)","authors":"Hanane BenZetta , Faiza Baali , Nadjette Djemouai , Sofia Ayari-Guentri , Somia Saad , Kathia Belaid , Elyes Kelai","doi":"10.1080/14786419.2024.2425811","DOIUrl":"10.1080/14786419.2024.2425811","url":null,"abstract":"<div><div>The essential oils (EOs) of <em>Cymbopogon schoenanthus</em> (L.) Spreng. collected from Ghardaïa Province were analyzed for their chemical composition by GC-MS analysis. The results showed fifty-one identified compounds representing 94.34% of the whole EOs, with β-eudesmol (11.35%) and α-elemol (10.84%) as major compounds. The TAC, DPPH, and FRAP antioxidant activities of the EOs were moderate, while an important inhibition of 63.54 ± 2.41% was obtained for the β-carotene bleaching assay. The results of the antibacterial activity show that gentamicin had an inhibition zone of 21.66 ± 0.57 mm while <em>Bacillus cereus</em> was the most sensitive species (inhibition zone of 20.75 ± 0.50 mm). The wound-healing activity results showed contraction percentages on the 20<sup>th</sup> day of 99.35 ± 0.12%, which was similar to the positive control 1% allantoin (98.33 ± 0.17%). Our results show that <em>C.</em> <em>schoenanthus</em> is a source of many bioactive compounds with well-known antioxidant, antibacterial and wound-healing properties.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 791-803"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2417371
Rupamoni Thakur , Porismita Nath
Solanum violaceum Ortega is a perennial tropical shrub traditionally used as conventional medicine for the treatment of various ailments. The present study aims to validate the use of S. violaceum Ortega leaf (SVLE) and fruit extracts (SVFE) in traditional medicine through untargeted metabolomics and assessment of its biological and phytochemical properties. GC-MS-based untargeted metabolomics identified derivatives of 59 and 50 metabolites in SVLE and SVFE, respectively. The study authenticated the presence of several bioactive compounds including Diosgenin, n-Hexadecanoic acid and Stigmasterol in SVLE and Ricinoleic acid, 9,12-Octadecadienoic acid and Oleic acid in SVFE, thus corroborating the use of the plant in traditional medicine as an anti-inflammatory and antioxidant agent. Both SVFE and SVLE demonstrated potent antioxidant, protease and anticoagulant properties with partial inhibitory effects on the physiological function of Factor Xa. This study provides insight into the phytochemical and pharmacological properties of S. violaceum and its potential ethnomedicinal relevance.
Solanum violaceum Ortega 是一种多年生热带灌木，传统上被用作治疗各种疾病的传统药物。本研究旨在通过非靶向代谢组学以及对其生物和植物化学特性的评估，验证 S. violaceum Ortega 叶（SVLE）和果实提取物（SVFE）在传统医学中的应用。基于 GC-MS 的非靶向代谢组学在 SVLE 和 SVFE 中分别鉴定出 59 和 50 种代谢物的衍生物。该研究证实了 SVLE 和 SVFE 中存在几种生物活性化合物，包括薯蓣皂苷、正十六烷酸和豆固醇，以及油酸、9,12-十八碳二烯酸和油酸，从而证实了该植物在传统医学中作为抗炎和抗氧化剂的用途。SVFE 和 SVLE 都具有很强的抗氧化、蛋白酶和抗凝特性，对 Xa 因子的生理功能有部分抑制作用。这项研究有助于深入了解 S. violaceum 的植物化学和药理特性及其潜在的民族药用价值。
{"title":"Metabolite profile and pharmacological relevance of Solanum violaceum Ortega leaf and fruit extracts","authors":"Rupamoni Thakur , Porismita Nath","doi":"10.1080/14786419.2024.2417371","DOIUrl":"10.1080/14786419.2024.2417371","url":null,"abstract":"<div><div><em>Solanum violaceum</em> Ortega is a perennial tropical shrub traditionally used as conventional medicine for the treatment of various ailments. The present study aims to validate the use of <em>S. violaceum</em> Ortega leaf (SVLE) and fruit extracts (SVFE) in traditional medicine through untargeted metabolomics and assessment of its biological and phytochemical properties. GC-MS-based untargeted metabolomics identified derivatives of 59 and 50 metabolites in SVLE and SVFE, respectively. The study authenticated the presence of several bioactive compounds including Diosgenin, n-Hexadecanoic acid and Stigmasterol in SVLE and Ricinoleic acid, 9,12-Octadecadienoic acid and Oleic acid in SVFE, thus corroborating the use of the plant in traditional medicine as an anti-inflammatory and antioxidant agent. Both SVFE and SVLE demonstrated potent antioxidant, protease and anticoagulant properties with partial inhibitory effects on the physiological function of Factor Xa. This study provides insight into the phytochemical and pharmacological properties of <em>S. violaceum</em> and its potential ethnomedicinal relevance.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 647-651"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2426210
Jing-Ling Ren , Pei-Lian Liu , Hong-Yan Yang , Zhong-Liu Zhou , Zi-Ming Chen , Shou-yuan Wu
In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of Glycosmis parviflora (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (1), and five previously known metabolites (2–6) were identified. The structure of the new compound (1) was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration of 1 was assigned by comparing its experimental ECD spectra with those reported for similar compound in the literature. Compounds 3 and 6 exhibited moderate inhibitory effects against acetylcholinesterase (AChE) with IC50 values of 35.1 and 2.8 mM, respectively.
{"title":"Glycosparvine A, a new indole alkaloid from the leaves of Glycosmis parviflora","authors":"Jing-Ling Ren , Pei-Lian Liu , Hong-Yan Yang , Zhong-Liu Zhou , Zi-Ming Chen , Shou-yuan Wu","doi":"10.1080/14786419.2024.2426210","DOIUrl":"10.1080/14786419.2024.2426210","url":null,"abstract":"<div><div>In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of <em>Glycosmis parviflora</em> (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (<strong>1</strong>), and five previously known metabolites (<strong>2</strong>–<strong>6</strong>) were identified. The structure of the new compound (<strong>1</strong>) was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration of <strong>1</strong> was assigned by comparing its experimental ECD spectra with those reported for similar compound in the literature. Compounds <strong>3</strong> and <strong>6</strong> exhibited moderate inhibitory effects against acetylcholinesterase (AChE) with IC<sub>50</sub> values of 35.1 and 2.8 mM, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 854-859"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2417837
Danil I. Falev , Alexandra A. Onuchina , Anna V. Faleva , Ilya S. Voronov , Dmitry S. Kosyakov , Nikolay V. Ulyanovskii
Cloudberry (Rubus chamaemorus L.) is a plant rich in various biologically active compounds. In this work, the composition and concentrations of pentacyclic triterpenoids (PCTs) and phytosterols in various parts of cloudberries were studied using high-performance liquid chromatography–tandem mass spectrometry by multiple reaction monitoring mode (MRM, targeted analysis) and precursor ion scan mode (non-targeted analysis and semi-quantitative determination). Moderately polar fractions of cloudberry leaves, sepals and berries extracts are rich in β-sitosterol glycoside and various triterpenoid acids, among which tormentic acid (∼190–1800 μg/g dw part of cloudberries) and its hydroxyl derivatives (∼3.1–470 μg/g dw part of cloudberries) predominate. Non-polar fractions are characterised by the presence of amyrins (0.76–110 μg/g dw part of cloudberries), β-sitosterol (62–750 µg/g dw part of cloudberries) and β-sitosterol glycoside (∼92–360 μg/g dw sepals).
{"title":"Analysis of pentacyclic triterpenoids and phytosterols in cloudberry (Rubus chamaemorus L.) by LC–MS/MS","authors":"Danil I. Falev , Alexandra A. Onuchina , Anna V. Faleva , Ilya S. Voronov , Dmitry S. Kosyakov , Nikolay V. Ulyanovskii","doi":"10.1080/14786419.2024.2417837","DOIUrl":"10.1080/14786419.2024.2417837","url":null,"abstract":"<div><div>Cloudberry (<em>Rubus chamaemorus L</em>.) is a plant rich in various biologically active compounds. In this work, the composition and concentrations of pentacyclic triterpenoids (PCTs) and phytosterols in various parts of cloudberries were studied using high-performance liquid chromatography–tandem mass spectrometry by multiple reaction monitoring mode (MRM, targeted analysis) and precursor ion scan mode (non-targeted analysis and semi-quantitative determination). Moderately polar fractions of cloudberry leaves, sepals and berries extracts are rich in β-sitosterol glycoside and various triterpenoid acids, among which tormentic acid (∼190–1800 μg/g dw part of cloudberries) and its hydroxyl derivatives (∼3.1–470 μg/g dw part of cloudberries) predominate. Non-polar fractions are characterised by the presence of amyrins (0.76–110 μg/g dw part of cloudberries), β-sitosterol (62–750 µg/g dw part of cloudberries) and β-sitosterol glycoside (∼92–360 μg/g dw sepals).</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 652-659"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2025.2487155
Erkin Tursun , Yujie Qiao , Le Dai , Jiaxing Yu , Abdulla Yusuf , Adila Abudurexiti
A total of twenty-one compounds were obtained from the whole plant of Cuscuta chinensis Lam. The compounds’ structures were identified as 3-hydroxy-N-phenethylpropanamide (1), (+)-pinoresinol-O-β-D- glucopyranoside (2), simplexoside (3), (+)-pinoresinol (4), scopoletin (5), (-)-loliolide (6), N-trans-feruloyltyramine (7), (+)-syringaresinol (8), medioresinol (9), 3,4-dehydrotheaspirone (10), 2-ethoxy-1H-pyrimidine-4,6-dione (11), ethyl 4-hydroxybenzoate(12), hydroquinone (13), vanillic acid (14), β-daucosterol (15), methyl 2,4,6-trihydroxybenzoate (16), roseoside (17), vomifoliol (18), pyrocatechol (19), E-p-coumaric acid (20), Z-p-hydroxy-cinnamic acid (21). Among them, ten compounds (1,3,5,6,10,11,16,17,18,19) were isolated from this plant for the first time, while compound 1 was isolated as an undescribed natural compound. Moreover, the dichloromethane and ethyl acetate extracts indicated potential bioactivity, and compound 2 showed certain anti-inflammatory activity. This study provides a scientific basis for elucidating the composites and activity of C. chinensis.
从菟丝草（Cuscuta chinensis Lam）全株中分离得到21个化合物。化合物的结构鉴定为：3-羟基- n -苯乙基丙酰胺(1)、(+)-松脂醇- o -β- d -葡萄糖苷(2)、单纯胞苷(3)、(+)-松脂醇(4)、东莨菪碱(5)、(-)-油橄榄内酯(6)、n -反式阿铁酰乙胺(7)、(+)-丁香松脂醇(8)、中松脂醇(9)、3,4-脱氢阿斯皮罗酮（10）、2-乙氧基- 1h -嘧啶-4,6-二酮（11）、4-羟基苯甲酸乙酯（12）、对苯二酚（13）、香草酸（14）、β-二羟基甾醇（15）、2,4,6-三羟基苯甲酸甲酯（16）、玫瑰苷（17）、vomifioliol（18）、邻苯二酚（19），e -对香豆酸（20），z -对羟基肉桂酸（21）。其中化合物1、3、5、6、10、11、16、17、18、19为首次从该植物中分离得到，化合物1为未描述的天然化合物。二氯甲烷和乙酸乙酯提取物具有潜在的生物活性，化合物2具有一定的抗炎活性。本研究为进一步研究中华草属植物的成分和活性提供了科学依据。
{"title":"Chemical constituents and biological activities of the whole plant of Cuscuta chinensis Lam","authors":"Erkin Tursun , Yujie Qiao , Le Dai , Jiaxing Yu , Abdulla Yusuf , Adila Abudurexiti","doi":"10.1080/14786419.2025.2487155","DOIUrl":"10.1080/14786419.2025.2487155","url":null,"abstract":"<div><div>A total of twenty-one compounds were obtained from the whole plant of <em>Cuscuta chinensis</em> Lam. The compounds’ structures were identified as 3-hydroxy-<em>N</em>-phenethylpropanamide (<strong>1</strong>), (+)-pinoresinol-<em>O</em>-<em>β</em>-D- glucopyranoside (<strong>2</strong>), simplexoside (<strong>3</strong>), (+)-pinoresinol (<strong>4</strong>), scopoletin (<strong>5</strong>), (-)-loliolide (<strong>6</strong>), <em>N</em>-<em>trans</em>-feruloyltyramine (<strong>7</strong>), (+)-syringaresinol (<strong>8</strong>), medioresinol (<strong>9</strong>), 3,4-dehydrotheaspirone (<strong>10</strong>), 2-ethoxy-1<em>H</em>-pyrimidine-4,6-dione (<strong>11</strong>), ethyl 4-hydroxybenzoate(<strong>12</strong>), hydroquinone (<strong>13</strong>), vanillic acid (<strong>14</strong>), <em>β</em>-daucosterol (<strong>15</strong>), methyl 2,4,6-trihydroxybenzoate (<strong>16</strong>), roseoside (<strong>17</strong>), vomifoliol (<strong>18</strong>), pyrocatechol (<strong>19</strong>), <em>E</em>-<em>p</em>-coumaric acid (<strong>20</strong>), <em>Z</em>-<em>p</em>-hydroxy-cinnamic acid (<strong>21</strong>). Among them, ten compounds (<strong>1</strong>,<strong>3</strong>,<strong>5</strong>,<strong>6</strong>,<strong>10</strong>,<strong>11</strong>,<strong>16</strong>,<strong>17</strong>,<strong>18</strong>,<strong>19</strong>) were isolated from this plant for the first time, while compound <strong>1</strong> was isolated as an undescribed natural compound. Moreover, the dichloromethane and ethyl acetate extracts indicated potential bioactivity, and compound <strong>2</strong> showed certain anti-inflammatory activity. This study provides a scientific basis for elucidating the composites and activity of <em>C. chinensis</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 937-942"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cucumis melo var. reticulatus Ser. (or netted melon ‘Earl’s Favourite’), a variety of Cucumis melo L., is widely cultivated in Shizuoka, Japan. However, the leaves and stems are discarded after harvest. Therefore, we investigated the chemical constituents of melon leaves to suggest potential applications. Air-dried melon leaves were extracted using methanol. The methanol extract was suspended in water and successively partitioned using n-hexane, ethyl acetate, and to yield each fraction. Eight flavone glycosides (1 − 8) and three terpenes (9 − 11) were obtained. The chemical structures of these compounds were determined via nuclear magnetic resonance and mass spectrometry. The antioxidant activity of compounds 1 − 8 was evaluated using a 2,2-diphenyl-1-picrylhydrazyl radical assay. All compounds showed radical-scavenging activity in the range of IC50, 24.2 − 129.5 μM, which depended on the number of hydroxyl groups on the benzene ring and ortho-substitution. Therefore, the leaves of C. melo may be considered valuable material for developing antioxidants.
{"title":"Component analysis of Cucumis melo L. leaves and their antioxidant activity","authors":"Takahiro Hosoya , Yuka Masuda , Seiji Ohba , Shigenori Kumazawa","doi":"10.1080/14786419.2024.2416508","DOIUrl":"10.1080/14786419.2024.2416508","url":null,"abstract":"<div><div><em>Cucumis melo var. reticulatus</em> Ser. (or netted melon ‘Earl’s Favourite’), a variety of <em>Cucumis melo</em> L., is widely cultivated in Shizuoka, Japan. However, the leaves and stems are discarded after harvest. Therefore, we investigated the chemical constituents of melon leaves to suggest potential applications. Air-dried melon leaves were extracted using methanol. The methanol extract was suspended in water and successively partitioned using <em>n</em>-hexane, ethyl acetate, and to yield each fraction. Eight flavone glycosides (<strong>1 </strong>−<strong> 8</strong>) and three terpenes (<strong>9 </strong>−<strong> 11</strong>) were obtained. The chemical structures of these compounds were determined <em>via</em> nuclear magnetic resonance and mass spectrometry. The antioxidant activity of compounds <strong>1 </strong>−<strong> 8</strong> was evaluated using a 2,2-diphenyl-1-picrylhydrazyl radical assay. All compounds showed radical-scavenging activity in the range of IC<sub>50</sub>, 24.2 − 129.5 μM, which depended on the number of hydroxyl groups on the benzene ring and <em>ortho</em>-substitution. Therefore, the leaves of <em>C. melo</em> may be considered valuable material for developing antioxidants.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 627-634"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2421908
Whistler Lucain Dibahteu Tankoua , Ernestine Zondegoumba T. Nkwengoua , Soh Desiré , Olivier Ndogo Eteme , Emmanuella Marthe Tchana Satchet , Rodrigo Santos A. de Araujo , Anuraj Nayarisseri , Maria do Carmo Alves de Lima , Thiago Mendonça de Aquino , Nyassé Barthélémy , Francisco J. B. Mendonça-Junior
Zanthoxylum leprieurii is a medicinal plant widely studied due to its great phytochemical diversity, especially its acrinonic alkaloids, which have shown to be promising anticancer candidates. The aim of this work was to promote the isolation of acridonic alkaloids from fruits of Z. leprieurii and carried out absorption and fluorescence spectroscopy studies with calf thymus DNA and BSA. Five acridone alkaloids have been isolated, including the first description of 3-desmethoxy arborinine (2). In the study of interaction with biomacromolecules it was observed that all compounds show interaction with calf thymus DNA and BSA. Compound 2 promoted the bigger increase in BSA fluorescence (3.01%) with a lower fluorescence quenching constant (Ksv = 0.13 × 104). Taken together, these results reaffirm the great phytochemical diversity of Z. leprieurii, and show that acridonic alkaloids have an affinity with both DNA and BSA, therefore providing clues to their mechanisms of action related to their anticancer activities.
白花蛇舌草（Zanthoxylum leprieurii）是一种药用植物，因其植物化学成分的多样性而被广泛研究，特别是其刺五加生物碱，已被证明是有希望的抗癌候选物质。这项工作旨在促进从白头翁果实中分离出吖啶酮生物碱，并与小牛胸腺 DNA 和 BSA 一起进行了吸收和荧光光谱研究。已分离出五种吖啶酮生物碱，包括首次描述的 3-去甲氧基 arborinine（2）。在与生物大分子相互作用的研究中发现，所有化合物都与小牛胸腺 DNA 和 BSA 发生了相互作用。化合物 2 以较低的荧光淬灭常数（Ksv = 0.13 × 104）促进了 BSA 荧光的大幅增加（3.01%）。综上所述，这些结果再次证实了白头翁属植物化学成分的多样性，并表明吖啶生物碱与 DNA 和 BSA 都有亲和力，从而为了解其抗癌活性的作用机制提供了线索。
{"title":"Spectroscopic exploration of mode of binding of ctDNA and BSA with acridone alkaloids isolated from Zanthoxylum leprieurii (Rutaceae)","authors":"Whistler Lucain Dibahteu Tankoua , Ernestine Zondegoumba T. Nkwengoua , Soh Desiré , Olivier Ndogo Eteme , Emmanuella Marthe Tchana Satchet , Rodrigo Santos A. de Araujo , Anuraj Nayarisseri , Maria do Carmo Alves de Lima , Thiago Mendonça de Aquino , Nyassé Barthélémy , Francisco J. B. Mendonça-Junior","doi":"10.1080/14786419.2024.2421908","DOIUrl":"10.1080/14786419.2024.2421908","url":null,"abstract":"<div><div><em>Zanthoxylum leprieurii</em> is a medicinal plant widely studied due to its great phytochemical diversity, especially its acrinonic alkaloids, which have shown to be promising anticancer candidates. The aim of this work was to promote the isolation of acridonic alkaloids from fruits of <em>Z. leprieurii</em> and carried out absorption and fluorescence spectroscopy studies with calf thymus DNA and BSA. Five acridone alkaloids have been isolated, including the first description of 3-desmethoxy arborinine (<strong>2</strong>). In the study of interaction with biomacromolecules it was observed that all compounds show interaction with calf thymus DNA and BSA. Compound <strong>2</strong> promoted the bigger increase in BSA fluorescence (3.01%) with a lower fluorescence quenching constant (Ksv = 0.13 × 10<sup>4</sup>). Taken together, these results reaffirm the great phytochemical diversity of <em>Z. leprieurii</em>, and show that acridonic alkaloids have an affinity with both DNA and BSA, therefore providing clues to their mechanisms of action related to their anticancer activities.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 675-689"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2425796
Jia-Li He , Xiao-Dong Jiang , Yu-Man Gan , Xin-Jian Qu , Xiang-Xi Yi , Yong-Hong Liu , Cheng-Hai Gao , Meng Bai
One new cyclic heptapeptide, cadophorin C (1), and one known analogue cadophorin B (2) were isolated from the mangrove-derived fungus Penicillium sp. GXIMD 03101 from the mangrove Acanthus ilicifolius L. The chemical structure of 1 was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values. Compounds 1 and 2 were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. The results showed that compounds 1 and 2 have weak activity against Vibrio harveyi with MIC values of 3.12 and 12.5 μg/mL, respectively. Compounds 1 and 2 have significant inhibitory activity against BPH with IC50 values of 2.62 and 2.23 μM, respectively.
{"title":"Cadophorin C, a new cyclic heptapeptide isolated from a mangrove-derived fungus Penicillium sp. GXIMD 03101","authors":"Jia-Li He , Xiao-Dong Jiang , Yu-Man Gan , Xin-Jian Qu , Xiang-Xi Yi , Yong-Hong Liu , Cheng-Hai Gao , Meng Bai","doi":"10.1080/14786419.2024.2425796","DOIUrl":"10.1080/14786419.2024.2425796","url":null,"abstract":"<div><div>One new cyclic heptapeptide, cadophorin C (<strong>1</strong>), and one known analogue cadophorin B (<strong>2</strong>) were isolated from the mangrove-derived fungus <em>Penicillium</em> sp. GXIMD 03101 from the mangrove <em>Acanthus ilicifolius</em> L. The chemical structure of <strong>1</strong> was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values. Compounds <strong>1</strong> and <strong>2</strong> were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. The results showed that compounds <strong>1</strong> and <strong>2</strong> have weak activity against <em>Vibrio harveyi</em> with MIC values of 3.12 and 12.5 μg/mL, respectively. Compounds <strong>1</strong> and <strong>2</strong> have significant inhibitory activity against BPH with IC<sub>50</sub> values of 2.62 and 2.23 μM, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 769-775"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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