Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2286605
Aijiao Zhong , Peng Shen , Yue Sun , Jiaxin Feng , Junyi Zhu , Li Li , Zijing Wu , Hao Zang
Aegopodium alpestre Ledeb (A. alpestre) is a plant known for its fragrant smell and has been traditionally used to treat influenza. However, despite its widespread use, there is no research on its flowering aerial parts. This study aims to contribute to the understanding the flowering aerial parts by investigating its volatile oil. The essential oil was extracted through hydrodistillation and analysed using GC-MS. The analysis identified 54 compounds, which accounted for 95.16% of the oil composition. The major components are germacrene D (31.68%), β-caryophyllene (16.07%), and (E)-β-farnesene (7.99%). To evaluate the antioxidant activity of volatile oil, six antioxidant experiments were conducted. The results indicated that volatile oil exhibited significant 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt and hydroxyl radical scavenging abilities. Furthermore, the antibacterial activity of volatile oil was assessed against four common pathogenic bacteria. The findings demonstrated that volatile oil displayed potent antibacterial activity against Escherichia coli and Aerogenic bacterium.
{"title":"Chemical composition and biological evaluation of the essential oil of the flowering aerial parts of Aegopodium alpestre Ledeb","authors":"Aijiao Zhong , Peng Shen , Yue Sun , Jiaxin Feng , Junyi Zhu , Li Li , Zijing Wu , Hao Zang","doi":"10.1080/14786419.2023.2286605","DOIUrl":"10.1080/14786419.2023.2286605","url":null,"abstract":"<div><div><em>Aegopodium alpestre</em> Ledeb (<em>A. alpestre</em>) is a plant known for its fragrant smell and has been traditionally used to treat influenza. However, despite its widespread use, there is no research on its flowering aerial parts. This study aims to contribute to the understanding the flowering aerial parts by investigating its volatile oil. The essential oil was extracted through hydrodistillation and analysed using GC-MS. The analysis identified 54 compounds, which accounted for 95.16% of the oil composition. The major components are germacrene D (31.68%), <em>β</em>-caryophyllene (16.07%), and (<em>E</em>)-<em>β</em>-farnesene (7.99%). To evaluate the antioxidant activity of volatile oil, six antioxidant experiments were conducted. The results indicated that volatile oil exhibited significant 2,2’-azino-<em>bis</em>(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt and hydroxyl radical scavenging abilities. Furthermore, the antibacterial activity of volatile oil was assessed against four common pathogenic bacteria. The findings demonstrated that volatile oil displayed potent antibacterial activity against <em>Escherichia coli</em> and <em>Aerogenic bacterium</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 998-1003"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2288232
Livia Reisen Perin , Luciana Alves Parreira , Estevão Carlos Silva Barcelos , Mario Ferreira Conceição Santos , Luciano Menini , Daniel de Oliveira Gomes , Francisco de Paula Careta
Cutaneous and visceral leishmaniasis are public health problems in Africa, Asia, Europe, and America. The treatment has a high cost and toxicity. Thus, this work aims to evaluate the leishmanicidal activity of alpha-bisabolol and its three synthetic derivatives, P1, P2, and P3, on the promastigotes and amastigotes Leishmania infantum and L. amazonensis forms. Alpha-bisabolol showed the lowest IC50 with 3.43 for L. amazonensis promastigotes, while P1 was the most toxic for L. infantum with an IC50 of 9.10. The derivative P3 was better for the amastigote form, with an IC50 of 3.39 for L. amazonensis. All the compounds effectively decreased the intracellular load of amastigote and its ability to turn promastigote again. Thus, alpha-bisabolol and its three synthetic derivatives were effective in their leishmanicidal activity. Therefore, it can be an option for developing new treatments against leishmaniasis.
{"title":"In vitro effect of alpha-bisabolol and its synthetic derivatives on macrophages, promastigotes, and amastigotes of Leishmania amazonensis and Leishmania infantum","authors":"Livia Reisen Perin , Luciana Alves Parreira , Estevão Carlos Silva Barcelos , Mario Ferreira Conceição Santos , Luciano Menini , Daniel de Oliveira Gomes , Francisco de Paula Careta","doi":"10.1080/14786419.2023.2288232","DOIUrl":"10.1080/14786419.2023.2288232","url":null,"abstract":"<div><div>Cutaneous and visceral leishmaniasis are public health problems in Africa, Asia, Europe, and America. The treatment has a high cost and toxicity. Thus, this work aims to evaluate the leishmanicidal activity of alpha-bisabolol and its three synthetic derivatives, P1, P2, and P3, on the promastigotes and amastigotes <em>Leishmania infantum</em> and <em>L. amazonensis</em> forms. Alpha-bisabolol showed the lowest IC<sub>50</sub> with 3.43 for <em>L. amazonensis</em> promastigotes, while P1 was the most toxic for <em>L. infantum</em> with an IC<sub>50</sub> of 9.10. The derivative P3 was better for the amastigote form, with an IC<sub>50</sub> of 3.39 for <em>L. amazonensis</em>. All the compounds effectively decreased the intracellular load of amastigote and its ability to turn promastigote again. Thus, alpha-bisabolol and its three synthetic derivatives were effective in their leishmanicidal activity. Therefore, it can be an option for developing new treatments against leishmaniasis.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 1004-1009"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2290150
Denise M. B. Ghiraldi , Paula C. Perin , Diego L. Lucca , Eduardo J. Pilau , Silvana M. de Oliveira , Beatriz V. Diniz , Melyssa F. N. Negri , Maria A. Milaneze-Gutierre , Fabiana T. R. Martinelli , Roberto G. S. Berlinck , Armando M. Pomini
The phytochemical study of Cattleya intermedia (Orchidaceae) led to the isolation of two new stilbenoids and one new 9,10-dihydrophenanthrene, 4′,5-dihydroxy-2′,3-dimethoxy-dihydrostilbene (1), 3,6′-dihydroxy-4′-methoxy-dihydrostilbene (2) and 1,2,6-trihydroxy-3,8-dimethoxy-9,10-dihydrophenanthrene (3), named cattleymediol, cattleyol and phenanmediol, respectively, in addition to other five known compounds (4–8). The structural elucidations of the isolated compounds were carried out through the analyses of the one-dimensional 1H,1³C and NOE NMR spectra, and the 2D HSQC, HMBC, COSY and NOESY spectra, besides high-resolution mass spectrometry. In addition to this, the crude extract and its main fractions were analysed by ultra-high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC-QTOF-MS/MS), leading to the putative identification of several other compounds, including flavonoids and organic acids derivatives. Finally, the main fractions of the crude extract, and the pure compounds cattleymediol (1) and lusiantridine (7), had their antiproliferative activities evaluated against human cancerous HeLa and non-cancerous VERO cells.
{"title":"Stilbenes, phenanthrenes and antiproliferative activity of Cattleya intermedia","authors":"Denise M. B. Ghiraldi , Paula C. Perin , Diego L. Lucca , Eduardo J. Pilau , Silvana M. de Oliveira , Beatriz V. Diniz , Melyssa F. N. Negri , Maria A. Milaneze-Gutierre , Fabiana T. R. Martinelli , Roberto G. S. Berlinck , Armando M. Pomini","doi":"10.1080/14786419.2023.2290150","DOIUrl":"10.1080/14786419.2023.2290150","url":null,"abstract":"<div><div>The phytochemical study of <em>Cattleya intermedia</em> (Orchidaceae) led to the isolation of two new stilbenoids and one new 9,10-dihydrophenanthrene, 4′,5-dihydroxy-2′,3-dimethoxy-dihydrostilbene (<strong>1</strong>), 3,6′-dihydroxy-4′-methoxy-dihydrostilbene (<strong>2</strong>) and 1,2,6-trihydroxy-3,8-dimethoxy-9,10-dihydrophenanthrene (<strong>3</strong>), named cattleymediol, cattleyol and phenanmediol, respectively, in addition to other five known compounds (<strong>4–8</strong>). The structural elucidations of the isolated compounds were carried out through the analyses of the one-dimensional <sup>1</sup>H,<sup>1</sup>³C and NOE NMR spectra, and the 2D HSQC, HMBC, COSY and NOESY spectra, besides high-resolution mass spectrometry. In addition to this, the crude extract and its main fractions were analysed by ultra-high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC-QTOF-MS/MS), leading to the putative identification of several other compounds, including flavonoids and organic acids derivatives. Finally, the main fractions of the crude extract, and the pure compounds cattleymediol (<strong>1</strong>) and lusiantridine (<strong>7</strong>), had their antiproliferative activities evaluated against human cancerous HeLa and non-cancerous VERO cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 769-778"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2309322
Saghar Ketebchi , Maryam Papari Moghadamfard
In this review out of 300 selected articles 70 articles were evaluated, and the most significant compounds impacting COVID-19 and their mechanism of action were introduced. The compounds belong to four categories as follow: Phenolic, Flavonoid, Terpenoid, and Alkaloid compounds. In the phenol groups, the most effective compounds are scutellarin (suppressor of COVID-19 virus), thymol and carvacrol (the most inhibitory effect on COVID-19 virus), in the flavonoid groups, hesperdin (a strong inhibitor on COVID-19), in the terpenoids, methyl tanshinonate and sojil COVID-19 inhibitory effect) and 1,8-cineol (COVID-19 inhibitory effect) and in the last group, niglidine and quinoline alkaloid compounds (COVID-19 inhibitory effect) have been identified and introduced. These compounds have shown promising results due to their structure and effective mechanisms on COVID-19, so it can be an idea for researchers in this field to try to produce drugs by using natural compounds against the COVID-19 and Corona viruses.
{"title":"A review on the effective natural compounds of medicinal plants on the COVID-19","authors":"Saghar Ketebchi , Maryam Papari Moghadamfard","doi":"10.1080/14786419.2024.2309322","DOIUrl":"10.1080/14786419.2024.2309322","url":null,"abstract":"<div><div>In this review out of 300 selected articles 70 articles were evaluated, and the most significant compounds impacting COVID-19 and their mechanism of action were introduced. The compounds belong to four categories as follow: Phenolic, Flavonoid, Terpenoid, and Alkaloid compounds. In the phenol groups, the most effective compounds are scutellarin (suppressor of COVID-19 virus), thymol and carvacrol (the most inhibitory effect on COVID-19 virus), in the flavonoid groups, hesperdin (a strong inhibitor on COVID-19), in the terpenoids, methyl tanshinonate and sojil COVID-19 inhibitory effect) and 1,8-cineol (COVID-19 inhibitory effect) and in the last group, niglidine and quinoline alkaloid compounds (COVID-19 inhibitory effect) have been identified and introduced. These compounds have shown promising results due to their structure and effective mechanisms on COVID-19, so it can be an idea for researchers in this field to try to produce drugs by using natural compounds against the COVID-19 and Corona viruses.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 834-847"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2323531
Nahla S. El-Gazzar
Tamarindus indica L., the sole species in the genus Tamarind, which is a member of the subfamily Caesalpiniaceae in the family Leguminosae (Fabaceae), is extensively dispersed in many tropical and subtropical regions. This plant’s Arabic name, Tamr Al-Hindi, is the basis for its English name, Tamarind. In traditional medicine, this genus has played a major role since the time of the ancient Egyptians. Folkloric medicine has traditionally used Tamarind to treat a variety of conditions, including diabetes mellitus, fever, malaria, ulcers, diarrhoea, dysentery and wounds. The primary bioactive components of this species, which have a variety of biological functions, have been identified as flavonoids, phenolic contents, sterols, triterpenes, fatty acids, sugars and other substances. Genus Tamarind has been shown to have anti-inflammatory, analgesic, anti-pyretic, antibacterial, hypolipidemic, anti-diabetic, hepatoprotective, anti-ulcerogenic and antioxidant properties. This article provides an overview of the identified chemicals from T. indica together with their stated biological activities.
{"title":"Tamarind genus chemical composition and biological activities","authors":"Nahla S. El-Gazzar","doi":"10.1080/14786419.2024.2323531","DOIUrl":"10.1080/14786419.2024.2323531","url":null,"abstract":"<div><div><em>Tamarindus indica</em> L., the sole species in the genus <em>Tamarind</em>, which is a member of the subfamily Caesalpiniaceae in the family Leguminosae (Fabaceae), is extensively dispersed in many tropical and subtropical regions. This plant’s Arabic name, Tamr Al-Hindi, is the basis for its English name, Tamarind. In traditional medicine, this genus has played a major role since the time of the ancient Egyptians. Folkloric medicine has traditionally used <em>Tamarind</em> to treat a variety of conditions, including diabetes mellitus, fever, malaria, ulcers, diarrhoea, dysentery and wounds. The primary bioactive components of this species, which have a variety of biological functions, have been identified as flavonoids, phenolic contents, sterols, triterpenes, fatty acids, sugars and other substances. Genus <em>Tamarind</em> has been shown to have anti-inflammatory, analgesic, anti-pyretic, antibacterial, hypolipidemic, anti-diabetic, hepatoprotective, anti-ulcerogenic and antioxidant properties. This article provides an overview of the identified chemicals from <em>T. indica</em> together with their stated biological activities.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 935-947"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2288234
Lorena da Graça Pedrosa de Macena , Leonardo dos Santos Corrêa Amorim , Kauê Francisco Corrêa de Souza e Souza , Luíza Dantas Pereira , Claudio Cesar Cirne dos Santos , Caroline de Souza Barros , Carlos José Brito Ramos , Marcos Vinicius Santana , Helena Carla Castro , Valéria Laneuville Teixeira , Ana Maria Viana Pinto , Helena de Souza Pereira , Izabel Christina Nunes de Palmer Paixão
Herpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emergence of resistant strains has reduced the efficacy in treatment. Several studies have shown marine seaweed biological activities, but there are no studies yet about the activity anti-HSV-2 of two its secundary metabolites, atomaric acid (1) and marine dolastane (2), isolated from Stypopodium zonale and Canistrocarpus cervicornis respectively. Therefore, we evaluated the anti-HSV-2 activity of compounds 1 and 2. Both compounds showed anti-HSV-2 activity with low cytotoxicity and compound 1 inactivated 90% of the viral particles at 50 µM. Both compounds inhibited the penetration and results in silico indicated the compound 1 as possible therapy alternative anti -HSV-2.
{"title":"Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2","authors":"Lorena da Graça Pedrosa de Macena , Leonardo dos Santos Corrêa Amorim , Kauê Francisco Corrêa de Souza e Souza , Luíza Dantas Pereira , Claudio Cesar Cirne dos Santos , Caroline de Souza Barros , Carlos José Brito Ramos , Marcos Vinicius Santana , Helena Carla Castro , Valéria Laneuville Teixeira , Ana Maria Viana Pinto , Helena de Souza Pereira , Izabel Christina Nunes de Palmer Paixão","doi":"10.1080/14786419.2023.2288234","DOIUrl":"10.1080/14786419.2023.2288234","url":null,"abstract":"<div><div>Herpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emergence of resistant strains has reduced the efficacy in treatment. Several studies have shown marine seaweed biological activities, but there are no studies yet about the activity anti-HSV-2 of two its secundary metabolites, atomaric acid (1) and marine dolastane (2), isolated from <em>Stypopodium zonale</em> and <em>Canistrocarpus cervicornis</em> respectively. Therefore, we evaluated the anti-HSV-2 activity of compounds 1 and 2. Both compounds showed anti-HSV-2 activity with low cytotoxicity and compound 1 inactivated 90% of the viral particles at 50 µM. Both compounds inhibited the penetration and results <em>in silico</em> indicated the compound 1 as possible therapy alternative anti -HSV-2.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 712-717"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cereus jamacaru, popularly known as mandacaru, is a Cacactacea native to the Caatinga of Brazil, but it is distributed in arid and semiarid regions worldwide. This plant is used for various purposes, such as food, animal fodder, civil construction, and as an ornamental and medicinal plant. Traditional medicine uses the cladodes, roots, and seeds of C. jamacaru to treat various diseases. This review discusses the ethnobotanical uses, phytochemical composition, and biological properties of C. jamacaru. The data demonstrate that C. jamacaru produces a wide range of secondary metabolites involved in the defense mechanism against biotic agents and abiotic stresses. Carbohydrate polymers, phenolic compounds, terpenes, and bioactive nitrogen compounds, have been identified and linked to this plant’s biological properties. The present review will support future scientific research in identifying new bioproducts and demonstrating the potential of C. jamacaru as a food and medicinal plant.
Cereus jamacaru，俗称曼达卡鲁，是一种仙人掌科植物，原产于巴西的卡廷加地区，但分布于世界各地的干旱和半干旱地区。这种植物有多种用途，如食用、动物饲料、民用建筑、观赏和药用。传统医学利用 C. jamacaru 的叶片、根茎和种子治疗各种疾病。本综述讨论了 C. jamacaru 的民族植物学用途、植物化学成分和生物特性。数据表明，C. jamacaru 能产生多种次生代谢产物，参与对生物制剂和非生物压力的防御机制。已发现的碳水化合物聚合物、酚类化合物、萜类化合物和生物活性氮化合物与这种植物的生物特性有关。本综述将支持未来的科学研究，以确定新的生物产品，并证明 C. jamacaru 作为食品和药用植物的潜力。
{"title":"Ethnomedical uses, biocompounds and biological properties of Cereus Jamacaru DC. (Cactaceae): a comprehensive review","authors":"Leila Magda Rodrigues Almeida , Luzimar Gonzaga Fernandez","doi":"10.1080/14786419.2024.2330541","DOIUrl":"10.1080/14786419.2024.2330541","url":null,"abstract":"<div><div><em>Cereus jamacaru</em>, popularly known as mandacaru, is a Cacactacea native to the Caatinga of Brazil, but it is distributed in arid and semiarid regions worldwide. This plant is used for various purposes, such as food, animal fodder, civil construction, and as an ornamental and medicinal plant. Traditional medicine uses the cladodes, roots, and seeds of <em>C. jamacaru</em> to treat various diseases. This review discusses the ethnobotanical uses, phytochemical composition, and biological properties of <em>C. jamacaru</em>. The data demonstrate that <em>C. jamacaru</em> produces a wide range of secondary metabolites involved in the defense mechanism against biotic agents and abiotic stresses. Carbohydrate polymers, phenolic compounds, terpenes, and bioactive nitrogen compounds, have been identified and linked to this plant’s biological properties. The present review will support future scientific research in identifying new bioproducts and demonstrating the potential of <em>C. jamacaru</em> as a food and medicinal plant.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 961-975"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Accumulating evidence suggests that dietary fructose may play a role in the hyperuricaemia development, but the precise mechanism remains unclear. Hyperuricaemia is characterised by excessive production and deposition of urate crystals, and the metabolism of fructose has been implicated in the elevation of serum urate levels. The association between fructose intake and the risk of hyperuricaemia is explained by the metabolism of fructose in the liver, small intestine, and kidney. Many studies have confirmed the correlation between fructose consumption and an increased risk of developing hyperuricaemia, but more prospective studies to fully elucidate the role of fructose intake in the pathogenesis of hyperuricaemia are needed. It is important to note that maintaining a balanced diet, and lifestyle is crucial when considering fructose intake. Limiting the consumption of products high in added sugars and maintaining a healthy weight can contribute to reducing the risk of hyperuricaemia and associated health complications.
{"title":"Fructose-induced hyperuricaemia – protection factor or oxidative stress promoter?","authors":"Amelia Tero-Vescan , Ruxandra Ștefănescu , Tudor-Ionuț Istrate , Amalia Pușcaș","doi":"10.1080/14786419.2024.2327624","DOIUrl":"10.1080/14786419.2024.2327624","url":null,"abstract":"<div><div>Accumulating evidence suggests that dietary fructose may play a role in the hyperuricaemia development, but the precise mechanism remains unclear. Hyperuricaemia is characterised by excessive production and deposition of urate crystals, and the metabolism of fructose has been implicated in the elevation of serum urate levels. The association between fructose intake and the risk of hyperuricaemia is explained by the metabolism of fructose in the liver, small intestine, and kidney. Many studies have confirmed the correlation between fructose consumption and an increased risk of developing hyperuricaemia, but more prospective studies to fully elucidate the role of fructose intake in the pathogenesis of hyperuricaemia are needed. It is important to note that maintaining a balanced diet, and lifestyle is crucial when considering fructose intake. Limiting the consumption of products high in added sugars and maintaining a healthy weight can contribute to reducing the risk of hyperuricaemia and associated health complications.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 948-960"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to determine the chemical composition of essential oil (EO) extracted from the aerial parts of Schinus molle L., as well as its phytotoxicity on germination and seedling growth against some invasive weed species of cereal crops and wheat (Triticum durum, cultivar Chen’S). Gas chromatography/mass spectrometry (GC-MS) identified 51 components (representing 95.26% of the total EO composition). Shyobunone (10.14%), 1-phellandrene (9.63%), α-cadinol (7.46%), δ-cadinene (7.45%), and germacrene D (7.09%) were the most abundant compounds. The effect of EO on weed species germination, root and shoot growth was moderate to strong. When 0.02% and 0.03% of the oil were applied, EO had a strong phytotoxic effect, resulting in 100% failure of Bromus rigidus germination. In addition to determining the responsible compound, the observed phytotoxicity suggestedthat S. molle essential oil could be used as an environmentally friendly biopesticide.
{"title":"Chemical composition and allelopathic potential of Schinus molle L. (Anacardiaceae) essential oils against common weeds of wheat crop","authors":"Ammar Lalia , Abdelkader Harizia , Kada Righi , Zine Eddine Daikh","doi":"10.1080/14786419.2023.2287174","DOIUrl":"10.1080/14786419.2023.2287174","url":null,"abstract":"<div><div>This study aims to determine the chemical composition of essential oil (EO) extracted from the aerial parts of <em>Schinus molle</em> L., as well as its phytotoxicity on germination and seedling growth against some invasive weed species of cereal crops and wheat (<em>Triticum durum</em>, cultivar Chen’S). Gas chromatography/mass spectrometry (GC-MS) identified 51 components (representing 95.26% of the total EO composition). Shyobunone (10.14%), 1-phellandrene (9.63%), α-cadinol (7.46%), δ-cadinene (7.45%), and germacrene D (7.09%) were the most abundant compounds. The effect of EO on weed species germination, root and shoot growth was moderate to strong. When 0.02% and 0.03% of the oil were applied, EO had a strong phytotoxic effect, resulting in 100% failure of <em>Bromus rigidus</em> germination. In addition to determining the responsible compound, the observed phytotoxicity suggestedthat <em>S. molle</em> essential oil could be used as an environmentally friendly biopesticide.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 682-688"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The phytochemical investigation on the methanol extract of Viburnum betulifolium fruits resulted in the isolation and identification of two new lignan constituents (1 and 2) and seven known phenolic glycosides (3–9). The structures of new isolates, including their absolute configurations were elucidated by extensive spectroscopic analyses (1H and 13C NMR, HSQC, HMBC, HRESIMS, and ECD) and chemical methods. In the in vitro enzyme assays, compounds 1, 2, 6, and 8 showed potential α‑amylase and α-glucosidase inhibitory activities. Among them, compound 1 exhibited stronger inhibitory effects towards α-amylase and α-glucosidase with the IC50 values of 12.68 and 15.17 μM, respectively, than those of the positive control acarbose (IC50, 29.19 and 18.15 μM, respectively). In addition, the molecular docking analyses of compound 1 with strongest inhibition against the target enzymes were also performed.
{"title":"Lignan and phenolic glycosides from Viburnum betulifolium fruits and their α‑amylase and α-glucosidase inhibitory activities","authors":"Yi-Yuan Tang , Jia Chen , Hong-Juan Zhou , Wei Ji , Jian-Hua Shao , Feng-Min Zhang , Chun-Chao Zhao","doi":"10.1080/14786419.2023.2289084","DOIUrl":"10.1080/14786419.2023.2289084","url":null,"abstract":"<div><div>The phytochemical investigation on the methanol extract of <em>Viburnum betulifolium</em> fruits resulted in the isolation and identification of two new lignan constituents (<strong>1</strong> and <strong>2</strong>) and seven known phenolic glycosides (<strong>3</strong>–<strong>9</strong>). The structures of new isolates, including their absolute configurations were elucidated by extensive spectroscopic analyses (<sup>1</sup>H and <sup>13</sup>C NMR, HSQC, HMBC, HRESIMS, and ECD) and chemical methods. In the <em>in vitro</em> enzyme assays, compounds <strong>1</strong>, <strong>2</strong>, <strong>6</strong>, and <strong>8</strong> showed potential <em>α</em>‑amylase and <em>α</em>-glucosidase inhibitory activities. Among them, compound <strong>1</strong> exhibited stronger inhibitory effects towards <em>α</em>-amylase and <em>α</em>-glucosidase with the IC<sub>50</sub> values of 12.68 and 15.17 μM, respectively, than those of the positive control acarbose (IC<sub>50</sub>, 29.19 and 18.15 μM, respectively). In addition, the molecular docking analyses of compound <strong>1</strong> with strongest inhibition against the target enzymes were also performed.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 742-748"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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