Methicillin-resistant Staphylococcus aureus (MRSA) causes a variety of healthcare-associated and community-acquired infections. Due to limited availability of effective antimicrobials for treating MRSA infections, there is a growing need to explore alternative therapeutic approaches. Here, the antimicrobial activities of 19 oils, popularly used for their medicinal properties, were tested against MRSA USA300. Oils obtained from cinnamon, clove, tangerine, and coriander showed the most promising activities, demonstrating bactericidal, anti-adhesive and anti-biofilm activities, and synergistic properties with common antibiotics. Given that clove and cinnamon oils showed the best activities, they were incorporated into topical formulations. Not only did the formulations with oils maintain antimicrobial and anti-adhesive activities, but their anti-biofilm property was potentiated. Tests on Galleria mellonella larvae suggested that the formulation is non-toxic. The formulations proposed here are a great alternative for the decolonisation of surfaces containing MRSA and can help circumventing antimicrobial resistance, a growing threat in the hospital environment.
{"title":"Topical antimicrobial formulations using medicinal plant-derived essential oils targeting methicillin resistant Staphylococcus aureus","authors":"Fábio Assad Féres Rodrigues , Denise Mara Soares Bazzolli , Gaspar Diaz-Muñoz , Ciro César Rossi , Marisa Alves Nogueira Diaz","doi":"10.1080/14786419.2023.2287169","DOIUrl":"10.1080/14786419.2023.2287169","url":null,"abstract":"<div><div>Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) causes a variety of healthcare-associated and community-acquired infections. Due to limited availability of effective antimicrobials for treating MRSA infections, there is a growing need to explore alternative therapeutic approaches. Here, the antimicrobial activities of 19 oils, popularly used for their medicinal properties, were tested against MRSA USA300. Oils obtained from cinnamon, clove, tangerine, and coriander showed the most promising activities, demonstrating bactericidal, anti-adhesive and anti-biofilm activities, and synergistic properties with common antibiotics. Given that clove and cinnamon oils showed the best activities, they were incorporated into topical formulations. Not only did the formulations with oils maintain antimicrobial and anti-adhesive activities, but their anti-biofilm property was potentiated. Tests on <em>Galleria mellonella</em> larvae suggested that the formulation is non-toxic. The formulations proposed here are a great alternative for the decolonisation of surfaces containing MRSA and can help circumventing antimicrobial resistance, a growing threat in the hospital environment.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 665-673"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2290675
Maria Luiza Rodrigues de Castro-da-Silva , Anna Paula Farias-de-França , Isabella Ravazoli , Karollyna Corrêa Oliveira , Valéria de Campos Orsi , Edson Hideaki Yoshida , Renata Vasques da Silva Tavares , Yoko Oshima-Franco
Cannabidiol (CBD) has been used in diseases that affect the central nervous system. Its effects on the peripheral synapses are of great interest, since endocannabinoid receptors are expressed in muscles. CBD (0.3 mM) was analysed using mammalian and avian neuromuscular preparations, through myographic techniques in complementary protocols. Mammalian cells were examined by light microscopy while exogenous acetylcholine (40 µM) and potassium chloride (100 mM) were added into avian preparations, before and at the end of experiments. Pharmacological tools such as atropine (2 µM), polyethylene glycol (PEG 400, 20 µM), Ca2+ (1.8 mM), F55-6 (20 µg/mL), and nifedipine (1.3 mM) were assessed with CBD. In mice, CBD causes a facilitatory effect and paralysis, whereas in avian, paralysis. Concluding, CBD is responsible for activated or inhibited channels, for ACh release via muscarinic receptor modulation, and by the inhibition of nicotinic receptors leading to neuromuscular blockade, with no damage to striated muscle cells.
{"title":"Multi targets of cannabidiol (CBD) on skeletal mammalian and avian neuromuscular preparations","authors":"Maria Luiza Rodrigues de Castro-da-Silva , Anna Paula Farias-de-França , Isabella Ravazoli , Karollyna Corrêa Oliveira , Valéria de Campos Orsi , Edson Hideaki Yoshida , Renata Vasques da Silva Tavares , Yoko Oshima-Franco","doi":"10.1080/14786419.2023.2290675","DOIUrl":"10.1080/14786419.2023.2290675","url":null,"abstract":"<div><div>Cannabidiol (CBD) has been used in diseases that affect the central nervous system. Its effects on the peripheral synapses are of great interest, since endocannabinoid receptors are expressed in muscles. CBD (0.3 mM) was analysed using mammalian and avian neuromuscular preparations, through myographic techniques in complementary protocols. Mammalian cells were examined by light microscopy while exogenous acetylcholine (40 µM) and potassium chloride (100 mM) were added into avian preparations, before and at the end of experiments. Pharmacological tools such as atropine (2 µM), polyethylene glycol (PEG 400, 20 µM), Ca<sup>2+</sup> (1.8 mM), F55-6 (20 µg/mL), and nifedipine (1.3 mM) were assessed with CBD. In mice, CBD causes a facilitatory effect and paralysis, whereas in avian, paralysis. Concluding, CBD is responsible for activated or inhibited channels, for ACh release <em>via</em> muscarinic receptor modulation, and by the inhibition of nicotinic receptors leading to neuromuscular blockade, with no damage to striated muscle cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 787-796"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2317880
Shixing Li , Xiaolin Chen , Jiamei Tang , Dongdong Zhang , Yi Jiang , Huawei Zhang , Xiaomei Song , Wei Wang , Yuze Li
The genus Helleborus belongs to the Ranunculaceae family, distributed in southeastern Europe and western Asia. In folk medicine, it is commonly used as an anti-inflammatory and analgesic medicine for rheumatoid arthritis and bruises. Through reviewing recent articles, it was found that two hundred and twenty-six compounds have been isolated and identified from the genus Helleborus. These compounds include steroids, flavonoids, phenylpropanoids, lignans, anthraquinones, phenolics and others. Among them, the main chemical constituents are steroids. Pharmacological studies show Helleborus has anti-cancer, immunomodulatory, anti-inflammatory, analgesic, anti-hyperglycaemic, antioxidant and antibacterial properties. This article reviews the botany, phytochemistry, pharmacological effects and clinical applications of the genus Helleborus. Hopefully, it will provide a reference for in-depth research and exploitation of the genus Helleborus.
{"title":"Genus Helleborus: a comprehensive review of phytochemistry, pharmacology and clinical applications","authors":"Shixing Li , Xiaolin Chen , Jiamei Tang , Dongdong Zhang , Yi Jiang , Huawei Zhang , Xiaomei Song , Wei Wang , Yuze Li","doi":"10.1080/14786419.2024.2317880","DOIUrl":"10.1080/14786419.2024.2317880","url":null,"abstract":"<div><div>The genus <em>Helleborus</em> belongs to the Ranunculaceae family, distributed in southeastern Europe and western Asia. In folk medicine, it is commonly used as an anti-inflammatory and analgesic medicine for rheumatoid arthritis and bruises. Through reviewing recent articles, it was found that two hundred and twenty-six compounds have been isolated and identified from the genus <em>Helleborus</em>. These compounds include steroids, flavonoids, phenylpropanoids, lignans, anthraquinones, phenolics and others. Among them, the main chemical constituents are steroids. Pharmacological studies show <em>Helleborus</em> has anti-cancer, immunomodulatory, anti-inflammatory, analgesic, anti-hyperglycaemic, antioxidant and antibacterial properties. This article reviews the botany, phytochemistry, pharmacological effects and clinical applications of the genus <em>Helleborus</em>. Hopefully, it will provide a reference for in-depth research and exploitation of the genus <em>Helleborus</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 888-904"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2306917
Muhammad Faisal Maqbool , Sameena Gul , Muhammad Ishaq , Amara Maryam , Muhammad Khan , Hafiz Abdullah Shakir , Muhammad Irfan , Yongming Li , Tonghui Ma
Cancer, a highly deadly disease, necessitates safe, cost-effective, and readily accessible treatments to mitigate its impact. Theabrownin (THBR), a polyphenolic pigment found in Pu-erh tea, has garnered attention for its potential benefits in memory, liver health, and inflammation control. By observing different biological activities of THBR, recently researchers have unveiled THBR’s promising anticancer properties across various human cancer types. By examining existing studies, it is evident that THBR demonstrates substantial potential in inhibiting cell proliferation and reducing tumour size with minimal harm to normal cells. These effects are achieved through the modulation of key molecular markers such as Bcl-2, Bax, various Caspases, Poly (ADP-ribose) polymerase cleavage (Cl-PARP), and zinc finger E box binding homeobox 1 (ZEB 1). This review aims to provide in-depth insights into THBR’s role in cancer research. This review also elucidates the underlying anticancer mechanisms of THBR, offering promise as a novel anticancer drug to alleviate the global cancer burden.
{"title":"Theabrownin: a dietary nutraceutical with diverse anticancer mechanisms","authors":"Muhammad Faisal Maqbool , Sameena Gul , Muhammad Ishaq , Amara Maryam , Muhammad Khan , Hafiz Abdullah Shakir , Muhammad Irfan , Yongming Li , Tonghui Ma","doi":"10.1080/14786419.2024.2306917","DOIUrl":"10.1080/14786419.2024.2306917","url":null,"abstract":"<div><div>Cancer, a highly deadly disease, necessitates safe, cost-effective, and readily accessible treatments to mitigate its impact. Theabrownin (THBR), a polyphenolic pigment found in Pu-erh tea, has garnered attention for its potential benefits in memory, liver health, and inflammation control. By observing different biological activities of THBR, recently researchers have unveiled THBR’s promising anticancer properties across various human cancer types. By examining existing studies, it is evident that THBR demonstrates substantial potential in inhibiting cell proliferation and reducing tumour size with minimal harm to normal cells. These effects are achieved through the modulation of key molecular markers such as Bcl-2, Bax, various Caspases, Poly (ADP-ribose) polymerase cleavage (Cl-PARP), and zinc finger E box binding homeobox 1 (ZEB 1). This review aims to provide in-depth insights into THBR’s role in cancer research. This review also elucidates the underlying anticancer mechanisms of THBR, offering promise as a novel anticancer drug to alleviate the global cancer burden.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 817-833"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2403028
Sefa Gözcü , Zeynep Akşit , Ali Aydın , Mustafa Abdullah Yılmaz , Samed Şimşek
The present investigation focused on the comprehensive analysis of the phenolic profile of Centaurea glastifolia L. (Asteraceae) and the assessment of its diverse biological activities. Utilising LC-MS/MS, the phytochemical composition of the 70% methanol extract of Centaurea glastifolia (CG-ME) was thoroughly elucidated, revealing the presence of 30 distinct phytochemical compounds. Notably, major phenolic constituents identified in the extract included quinic acid, chlorogenic acid, luteolin-7-O-glucoside, kaempferol-3-O-glucoside, luteolin, and apigenin-7-O-glucoside. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities of CG-ME were investigated. The CG-ME exhibited a moderate capacity for scavenging DPPH radicals (IC50: 50.05 ± 1.58 µg/mL) and FRAP (63.96 ± 0.39 mg TE/g extract), indicating a moderate level of antioxidant activity. Moreover, CG-ME demonstrated significant antiproliferative effects (GI50: 1.10 and 1.30 µg/mL) on cancer cells (C6 and HTC cancer cell lines, respectively) while displaying low cytotoxicity towards normal cells (LC50: >1000 µg/mL). In terms of antibacterial activity, CG-ME was found to be inactive against tested both Gram-positive and Gram-negative bacterial strains (MIC > 500 µg/mL). The extracts had a promising antiproliferative effect on C6, HeLa, and HT29 cancer cell lines with a less cytotoxic effect (10.5–14.2%) against normal cells.
{"title":"Comprehensive phenolic profiling and biological evaluation of Centaurea glastifolia L. (Asteraceae)","authors":"Sefa Gözcü , Zeynep Akşit , Ali Aydın , Mustafa Abdullah Yılmaz , Samed Şimşek","doi":"10.1080/14786419.2024.2403028","DOIUrl":"10.1080/14786419.2024.2403028","url":null,"abstract":"<div><div>The present investigation focused on the comprehensive analysis of the phenolic profile of <em>Centaurea glastifolia</em> L. (Asteraceae) and the assessment of its diverse biological activities. Utilising LC-MS/MS, the phytochemical composition of the 70% methanol extract of <em>Centaurea glastifolia</em> (CG-ME) was thoroughly elucidated, revealing the presence of 30 distinct phytochemical compounds. Notably, major phenolic constituents identified in the extract included quinic acid, chlorogenic acid, luteolin-7-<em>O</em>-glucoside, kaempferol-3-<em>O</em>-glucoside, luteolin, and apigenin-7-<em>O</em>-glucoside. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities of CG-ME were investigated. The CG-ME exhibited a moderate capacity for scavenging DPPH radicals (IC<sub>50</sub>: 50.05 ± 1.58 µg/mL) and FRAP (63.96 ± 0.39 mg TE/g extract), indicating a moderate level of antioxidant activity. Moreover, CG-ME demonstrated significant antiproliferative effects (GI<sub>50</sub>: 1.10 and 1.30 µg/mL) on cancer cells (C6 and HTC cancer cell lines, respectively) while displaying low cytotoxicity towards normal cells (LC<sub>50</sub>: >1000 µg/mL). In terms of antibacterial activity, CG-ME was found to be inactive against tested both Gram-positive and Gram-negative bacterial strains (MIC > 500 µg/mL). The extracts had a promising antiproliferative effect on C6, HeLa, and HT29 cancer cell lines with a less cytotoxic effect (10.5–14.2%) against normal cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 633-644"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2285879
Iara Emanoely Francio , Dalva Paulus , Caroline Lermen Munhoz , Daiane Luckmann Balbinotti de França
This study aimed to determine the chemical composition of essential oils from A. gratíssima, O. basilicum, S. microphylla, T. riparia, and T. vulgaris and their antioxidant and antifungal activities against Alternaria alternata strains. Gas chromatography-mass spectrometry revealed that the major components of the essential oils were terpenes. The essential oils of S. microphylla and T. riparia showed higher antioxidant activities than the others. The essential oils of S. microphylla and T. riparia inhibited the growth of the fungus at 3.10 and 6.05 µL/mL, respectively. The essential oil of T. riparia inhibited 93.9% of the growth of the fungus and showed the highest in vivo efficiency in severity reduction (76.2%). We conclude that the essential oil of T. riparia shows promising antifungal activity and is an environmentally safe alternative for controlling fungal diseases in vegetables.
{"title":"Chemical composition of five essential oils and their antioxidant and in vitro and in vivo antifungal activities against Alternaria alternata in tomato crop","authors":"Iara Emanoely Francio , Dalva Paulus , Caroline Lermen Munhoz , Daiane Luckmann Balbinotti de França","doi":"10.1080/14786419.2023.2285879","DOIUrl":"10.1080/14786419.2023.2285879","url":null,"abstract":"<div><div>This study aimed to determine the chemical composition of essential oils from <em>A. gratíssima</em>, <em>O. basilicum</em>, <em>S. microphylla</em>, <em>T. riparia,</em> and <em>T. vulgaris</em> and their antioxidant and antifungal activities against <em>Alternaria alternata</em> strains. Gas chromatography-mass spectrometry revealed that the major components of the essential oils were terpenes. The essential oils of <em>S. microphylla</em> and <em>T. riparia</em> showed higher antioxidant activities than the others. The essential oils of <em>S. microphylla</em> and <em>T. riparia</em> inhibited the growth of the fungus at 3.10 and 6.05 µL/mL, respectively. The essential oil of <em>T. riparia</em> inhibited 93.9% of the growth of the fungus and showed the highest <em>in vivo</em> efficiency in severity reduction (76.2%). We conclude that the essential oil of <em>T. riparia</em> shows promising antifungal activity and is an environmentally safe alternative for controlling fungal diseases in vegetables.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 645-653"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138434528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2289081
Min Lei , Mengqing Wang , Wentao Ma , Na Li , Jiwen Huang , Xinjian Jiang , Wenhui Wu , Chaoyan Zhang
A new polysaccharide (AAP) was extracted from Auricularia auricula by water extraction and alcohol precipitation. The antioxidant activity in vitro showed that AAP had a good scavenging effect on ABTS free radicals. Then AAP was purified by DEAE-52 ion exchange chromatography to obtain the purified component pAAP. The structure analysis showed that the molecular weight (Mw) of pAAP was 96.768 kDa, which was composed of rhamnose (Rha), arabinose (Ara), fucose (Fuc), xylose (Xyl), mannose (Man), glucose (Glu) and galactose (Gal), with the ratio of 0.1:0.157:0.33:2.797:2.881:2.988:0.587, and contained α-pyranose configuration and β-pyranose configuration. Field emission scanning electron microscopy and atomic force microscopy revealed the special conformation of pAAP in the ring and chain shape.
{"title":"In vitro antioxidant activity of the polysaccharide from Auricularia auricula and its structural characterisation","authors":"Min Lei , Mengqing Wang , Wentao Ma , Na Li , Jiwen Huang , Xinjian Jiang , Wenhui Wu , Chaoyan Zhang","doi":"10.1080/14786419.2023.2289081","DOIUrl":"10.1080/14786419.2023.2289081","url":null,"abstract":"<div><div>A new polysaccharide (AAP) was extracted from <em>Auricularia auricula</em> by water extraction and alcohol precipitation. The antioxidant activity <em>in vitro</em> showed that AAP had a good scavenging effect on ABTS free radicals. Then AAP was purified by DEAE-52 ion exchange chromatography to obtain the purified component pAAP. The structure analysis showed that the molecular weight (Mw) of pAAP was 96.768 kDa, which was composed of rhamnose (Rha), arabinose (Ara), fucose (Fuc), xylose (Xyl), mannose (Man), glucose (Glu) and galactose (Gal), with the ratio of 0.1:0.157:0.33:2.797:2.881:2.988:0.587, and contained α-pyranose configuration and β-pyranose configuration. Field emission scanning electron microscopy and atomic force microscopy revealed the special conformation of pAAP in the ring and chain shape.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 734-741"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138569532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2288928
Matthieu Matcheme , Bernard Dabolé , Djaouda Moussa , Jean Noël Nyemb , Talla Emmanuel , Sophie Laurent , Céline Henoumont , Alessandro Venditti
Chemical investigation of Cordia myxa L. (Boraginaceae) resulted in the isolation of the following ten known compounds: 1-naphthaleneacetic-5-carboxy-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a-trimethyl-[1S-(1α,2β, 4a,8aα)]-acid (1), hexacosanoate-1-glyceryl (2), 3β-urs-12,20(30)-diene-27,28-dioic acid (3), 3β-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid (4), stigmasterol (5), stigmasterol-3-O-β-D-glucopyranoside (6), oleanolic-acid (7), 3-O-acetyl-oleanolic acid (8), betulin (9) and spinasterol-3β-O-D-glucopyranoside (10). The isolated compounds were characterised by using spectroscopic methods, 1D and 2D NMR, mass spectroscopy (ESI-MS) and by comparison with the literature data. To the best of our knowledge, compounds 1, 3, 4, 8 and 10 were isolated for the first time from the Cordia genus. This result improves the chemotaxonomy knowledge of the Cordia genus. The antibacterial activities were performed by the Muller–Hinton agar diffusion method. The antibacterial activities were studied on Salmonella typhi, Staphylococcus aureus, Vibrio cholerae, Pseudomonas aeruginosa and Escherichia coli ATCC 25922. Compounds 8 and 9, at 20.0 mg/mL resulted to be effective antimicrobial against E. coli, V. cholerae and P. aeruginosa.
从菖蒲科菖蒲草中分离到10个已知化合物:1-萘乙酸-5-羧基-1,2,3,4,4a,7,8,8 -a -八氢-1,2,4 -三甲基-[1S-(1α，2β， 4a,8aα)]-酸(1)，己糖酸-1-甘油三酯(2)，3- β- 12,20(30)-二烯-27,28-二烯酸(3)，3- β- d -葡萄糖吡喃基-12,20(30)-二烯-27,28-二烯酸(4)，豆甾醇(5)，豆甾醇-3- o- β- d -葡萄糖吡喃苷(6)，齐墩果酸(7)，3- o-乙酰齐墩果酸(8)，桦木素(9)和spinasterol-3 -β- o- d -葡萄糖吡喃苷(10)。通过波谱方法、一维和二维核磁共振、质谱(ESI-MS)以及与文献数据的比较，对分离得到的化合物进行了表征。化合物1、3、4、8和10为首次从该属植物中分离得到。这一结果提高了科迪亚属植物的化学分类学知识。采用Muller-Hinton琼脂扩散法测定其抑菌活性。研究了其对伤寒沙门氏菌、金黄色葡萄球菌、霍乱弧菌、铜绿假单胞菌和大肠埃希菌的抑菌活性。化合物8和9在20.0 mg/mL浓度下对大肠杆菌、霍乱弧菌和铜绿假单胞菌均有较好的抗菌作用。
{"title":"Chemical constituents from Cordia myxa L. (Boraginaceae) and their antibacterial activity","authors":"Matthieu Matcheme , Bernard Dabolé , Djaouda Moussa , Jean Noël Nyemb , Talla Emmanuel , Sophie Laurent , Céline Henoumont , Alessandro Venditti","doi":"10.1080/14786419.2023.2288928","DOIUrl":"10.1080/14786419.2023.2288928","url":null,"abstract":"<div><div>Chemical investigation of <em>Cordia myxa</em> L. (Boraginaceae) resulted in the isolation of the following ten known compounds: 1-naphthaleneacetic-5-carboxy-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a-trimethyl-[1<em>S</em>-(1<em>α</em>,2<em>β</em>, 4a,8a<em>α</em>)]-acid (<strong>1</strong>), hexacosanoate-1-glyceryl (<strong>2</strong>), 3<em>β</em>-urs-12,20(30)-diene-27,28-dioic acid (<strong>3</strong>), 3<em>β</em>-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid (<strong>4</strong>), stigmasterol (<strong>5</strong>), stigmasterol-3-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>6</strong>), oleanolic-acid (<strong>7</strong>), 3-<em>O</em>-acetyl-oleanolic acid (<strong>8</strong>), betulin (<strong>9</strong>) and spinasterol-3<em>β</em>-<em>O</em>-D-glucopyranoside (<strong>10</strong>). The isolated compounds were characterised by using spectroscopic methods, 1D and 2D NMR, mass spectroscopy (ESI-MS) and by comparison with the literature data. To the best of our knowledge, compounds <strong>1</strong>, <strong>3</strong>, <strong>4</strong>, <strong>8</strong> and <strong>10</strong> were isolated for the first time from the <em>Cordia</em> genus. This result improves the chemotaxonomy knowledge of the <em>Cordia</em> genus. The antibacterial activities were performed by the Muller–Hinton agar diffusion method. The antibacterial activities were studied on <em>Salmonella typhi</em>, <em>Staphylococcus aureus</em>, <em>Vibrio cholerae</em>, <em>Pseudomonas aeruginosa</em> and <em>Escherichia coli</em> ATCC 25922. Compounds <strong>8</strong> and <strong>9</strong>, at 20.0 mg/mL resulted to be effective antimicrobial against <em>E. coli</em>, <em>V. cholerae</em> and <em>P. aeruginosa.</em></div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 725-733"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2283758
Tatiane Cristina Silva Maiolini , Karen de Jesus Nicácio , Welton Rosa , Daniel de Oliveira Miranda , Mario Ferreira Conceição Santos , Paula Carolina Pires Bueno , João Henrique Ghilardi Lago , Patricia Sartorelli , Danielle Ferreira Dias , Daniela Aparecida Chagas de Paula , Marisi Gomes Soares
Many species from Myrtaceae have traditionally been used in traditional medicine as anti-inflammatory, antimicrobial, antidiarrheal, antioxidant and antirheumatic, besides in blood cholesterol reduction. In the present work, the anti-inflammatory activity of essential oils from eighteen Myrtaceae spp. were evaluated according to their ex-vivo anti-inflammatory activity in human blood, and the corresponding biomarkers were determined using untargeted metabolomics data and multivariate data analysis. From these studied species, six displayed anti-inflammatory activity with percentage rates of inhibition of PGE2 release above 70%. Caryophyllene oxide (1), humulene epoxide II (2), β-selinene (3), α-amorphene (4), α-selinene (5), germacrene A (6), β-bisabolene (7), α-muurolene (8), α-humulene (9), β-gurjunene (10), myrcene (11), β-elemene (12), α-cadinol (13), α-copaene (14), E-nerolidol (15) and ledol (16) were annotated as potential anti-inflammatory biomarkers. The results obtained in this study point to essential oils from species of the Myrtaceae family as a rich source of anti-inflammatory agents.
{"title":"Potential anti-inflammatory biomarkers from Myrtaceae essential oils revealed by untargeted metabolomics","authors":"Tatiane Cristina Silva Maiolini , Karen de Jesus Nicácio , Welton Rosa , Daniel de Oliveira Miranda , Mario Ferreira Conceição Santos , Paula Carolina Pires Bueno , João Henrique Ghilardi Lago , Patricia Sartorelli , Danielle Ferreira Dias , Daniela Aparecida Chagas de Paula , Marisi Gomes Soares","doi":"10.1080/14786419.2023.2283758","DOIUrl":"10.1080/14786419.2023.2283758","url":null,"abstract":"<div><div>Many species from Myrtaceae have traditionally been used in traditional medicine as anti-inflammatory, antimicrobial, antidiarrheal, antioxidant and antirheumatic, besides in blood cholesterol reduction. In the present work, the anti-inflammatory activity of essential oils from eighteen Myrtaceae spp. were evaluated according to their <em>ex-vivo</em> anti-inflammatory activity in human blood, and the corresponding biomarkers were determined using untargeted metabolomics data and multivariate data analysis. From these studied species, six displayed anti-inflammatory activity with percentage rates of inhibition of PGE2 release above 70%. Caryophyllene oxide (<strong>1</strong>), humulene epoxide II (<strong>2</strong>), <em>β</em>-selinene (<strong>3</strong>), <em>α</em>-amorphene (<strong>4</strong>), <em>α</em>-selinene (<strong>5</strong>), germacrene A (<strong>6</strong>), <em>β</em>-bisabolene (<strong>7</strong>), <em>α</em>-muurolene (<strong>8</strong>), <em>α</em>-humulene (<strong>9</strong>), <em>β</em>-gurjunene (<strong>10</strong>), myrcene (<strong>11</strong>), <em>β</em>-elemene (<strong>12</strong>), <em>α</em>-cadinol (<strong>13</strong>), <em>α</em>-copaene (<strong>14</strong>), <em>E</em>-nerolidol (<strong>15</strong>) and ledol (<strong>16</strong>) were annotated as potential anti-inflammatory biomarkers. The results obtained in this study point to essential oils from species of the Myrtaceae family as a rich source of anti-inflammatory agents.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 985-992"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138434529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2286612
Atiq-ur- Rehman
Anti-hyperlipidaemic effect of chloroform fraction of aerial parts of Zygophyllum indicum (Fagonia indica Burm.f.) was studied in rats. Adult Wistar albino rats were distributed into five groups. Rats of all groups except group I were given an intraperitoneal injection (Triton X-100) to induce hyperlipidaemia. Groups (I and II) served as normal and hyperlipidaemic control groups respectively. Group III and group IV were administered with 250 and 500 mg/kg chloroform fraction of the plant respectively after 18 h of inducing hyperlipidaemia. Group V was given 10 mg/kg of the standard atorvastatin. Chloroform fraction had significant (p < 0.05) hypolipidaemic effects on lipid profile and biochemical parameters with a protective effect on the liver in comparison to group II. F. indica with hypolipidaemic effect is useful in the management of hyperlipidaemia. Chloroform fraction with its constituents can be used as an antihyperlipidaemic supplement in developing countries for the development of novel therapeutic agents.
{"title":"Chemical profile and in vivo anti-hyperlipidaemic activity of chloroform fraction of Zygophyllum indicum in Triton X-100 induced hyperlipidaemic rats","authors":"Atiq-ur- Rehman","doi":"10.1080/14786419.2023.2286612","DOIUrl":"10.1080/14786419.2023.2286612","url":null,"abstract":"<div><div>Anti-hyperlipidaemic effect of chloroform fraction of aerial parts of <em>Zygophyllum indicum</em> (<em>Fagonia indica</em> Burm.f.) was studied in rats. Adult Wistar albino rats were distributed into five groups. Rats of all groups except group I were given an intraperitoneal injection (Triton X-100) to induce hyperlipidaemia. Groups (I and II) served as normal and hyperlipidaemic control groups respectively. Group III and group IV were administered with 250 and 500 mg/kg chloroform fraction of the plant respectively after 18 h of inducing hyperlipidaemia. Group V was given 10 mg/kg of the standard atorvastatin. Chloroform fraction had significant (<em>p</em> < 0.05) hypolipidaemic effects on lipid profile and biochemical parameters with a protective effect on the liver in comparison to group II. <em>F. indica</em> with hypolipidaemic effect is useful in the management of hyperlipidaemia. Chloroform fraction with its constituents can be used as an antihyperlipidaemic supplement in developing countries for the development of novel therapeutic agents.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 654-664"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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