Natural Product Research最新文献

This study presents the extraction and characterisation of bioactive compounds from Mimosa tenuiflora (syn. Mimosa hostilis), known as Tepescohuite, using supercritical CO₂. Extractions were performed at 314-328 K and 8-22 MPa for 90 min, with CO₂ flow rates of 40-50 mL·min^-1. The extracts were analysed by HPLC-MS, NMR, UV-Vis and FTIR spectroscopy. The major compound identified was N, N-dimethyltryptamine (DMT), an indole alkaloid with therapeutic potential in neuropsychiatric treatments, antiseptic formulations and wound healing. The interfacial behaviour of the extract was studied by surface tension measurements of aqueous solutions at 308.15 K using the drop volume method, and its foaming properties were evaluated by the Ross-Miles method at 298.15 K. The findings demonstrate the potential of M. tenuiflora as a sustainable source of bioactive and surface-active compounds for pharmaceutical and biotechnological applications.

A new polyketide derivative, pennafuredin (1), along with one known compound nafuredin (2), were isolated from Penicillium sp. HK-G2. The planar structure of pennafuredin (1) was characterised by comprehensive NMR spectroscopic analyses and HR-ESI-MS data. Its absolute configuration was elucidated by ML_J_DP4 probability analysis and ECD calculation. Pennafuredin (1) exhibited potent α-glucosidase inhibitory activity, with an inhibition rate of 83.97 ± 3.17% at a concentration of 1 mg/mL. Molecular docking analysis revealed that pennafuredin (1) displayed a superior binding affinity to α-glucosidase (-7.29 kcal/mol).

Urceola polymorpha is traditionally employed as both a food source and medicinal remedy in Vietnam and several other Southeast Asian countries. This study presents a comprehensive phytochemical investigation that resulted in the separation of a new compound, along with 14 additional compounds previously unreported in this species. Their structures were identified by the application of advanced spectroscopic techniques. In in vitro assays, isolated compounds significantly inhibited lipopolysaccharide (LPS)-induced NO, IL-1β, IL-6, and TNF-α production, and iNOS expression levels in RAW264.7 cells, indicating potential anti-inflammatory activity. Among them, compounds 10 and 11 exhibited the most potential for inhibitory effects. In silico approaches suggested that active compounds may interact with proteins involved in inflammation. Our findings not only support the phytochemical profile of U. polymorpha but also utilise its ethnopharmacological applications, highlighting its promise as a candidate for the development of functional foods and therapeutic strategies targeting inflammation-related disorders.

Phytochemical investigation of ethanol extract of the trunk of Aglaia Lawii (Wight) C. J. Saldanha led to the isolation and identification of 11 triterpenoids (1-11) including a novel tetranortirucallane-type alkaloid aglawic acid (1). Aglawic acid (1) was a novel tetranortirucallane-type alkaloid with an unusual butanoic acid moiety attached to nitrogen atom of the maleimide ring. To the best of our knowledge, compound 1 is the first example of a natural terpenoids with an unusual butanoic acid moiety. 1 possessed potent anti-inflammatory activity against NO production with IC₅₀ values of 9.65 μM compared with the positive control NG-monomethyl-L-arginine (L-NMMA, IC₅₀ = 33.85 μM). In addition, 1 was evaluated for cytotoxicity against five human tumour cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW480), but was found to be inactive.

Medicinal plants, specifically, have attracted considerable attention because of their widespread use and relatively limited occurrence of adverse effects. Cissus L. (family Vitaceae) consists of 13 genera and over 800 species, all of which are found in tropical regions with some also growing in the temperate zone. The Cissus species mainly climbing plants with tendrils and shrubs, and they have considerable medicinal importance. Our objective was to examine Cissus species to present an outline of the current understanding of their chemical components. The plants contain a variety of beneficial compounds such as flavonoids, vitamins, triterpenoids, saponins, stilbenes, iridoids, steroids, glycosides, and alkaloids. Overall, Cissus species represent a promising group of herbal medicines with significant health benefits, meriting further scientific exploration to translate traditional knowledge into modern medical applications.

Eleven compounds were isolated from the secondary metabolites of the marine fungus Aureobasidium pullulans 8438, including three novel compounds, 9-hydroxy-massoia lactone (1), Ethyl p-hydroxybenzoate (3 R,5R)-3,5-dihydroxydecanoate (2), and (R)-9,10-dihydroxypropyl 4-hydroxy-5-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien -1-yl) benzoate (3), along with 8 known compounds (4-11). Compounds 1, 2 and 4-9 are decanoic acid derivatives, while both compounds 3 and 11 are 3-farnesyl-p-hydroxybenzoic acid derivatives. The planar structures of the new compounds were determined using high-resolution mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) data. Their absolute configurations were established through the Snatzke method, quantum chemical calculations (including computational NMR and ECD), and DP4+ analysis. All isolated compounds were evaluated for their cytotoxic effects against human non-small cell lung cancer cells A549 and human cervical cancer cells HeLa.

This study aimed to investigate the phytochemical composition, antioxidant activity, and enzyme inhibition profile of Citrullus colocynthis and its synthesised silver nanoparticles (AgNPs). Silver nanoparticles (AgNPs) were synthesised using C. colocynthis fruit extract and characterised using various techniques, including UV-Visible Spectroscopy, SEM, XRD, and FTIR, which confirmed the successful formation of AgNPs. The AgNPs exhibited significant antioxidant activity, with IC₅₀ values of 0.45 ± 0.4 µg/mL, 0.45 ± 0.5 µg/mL, and 0.45 ± 0.1 µg/mL for DPPH, FICA, and HRSC assays, respectively. The nanoparticles also showed potent enzyme inhibition activity against urease, carbonic anhydrase, and xanthine oxidase, with IC₅₀ values of 90 ± 0.1 μg/mL, 221 ± 0.4 µg/mL, and 187 ± 0.9 µg/mL, respectively. Notably, the AgNPs demonstrated enhanced bioactivity compared to the plant extract, highlighting their potential as therapeutic agents. This study provides new insights into the antioxidant and enzyme inhibition potential of C. colocynthis AgNPs, warranting further investigation into their therapeutic applications.

The genus Leucas R.Br. (Lamiaceae) is widely distributed throughout Africa, southern Asia, and northeastern Australia. Leucas zeylanica (L.) W.T.Aiton and Leucas marrubioides Desf. are two species occurring in Sri Lanka that are extensively employed in traditional medicine. This study reports, for the first time, the chemical composition of the essential oils obtained from the wild aerial parts of these species collected in Sri Lanka. GC-MS analysis revealed that the essential oils of L. zeylanica (Lz) and L. marrubioides (Lm) are characterised by high contents of sesquiterpene hydrocarbons, with β-selinene (30.0%) and β-caryophyllene (25.6%) identified as the predominant constituents, respectively. The chemical profiles are discussed in comparison with previously published data on essential oils from other Leucas species. Furthermore, a comprehensive review of the volatile constituents reported to date for the genus Leucas is presented.

АBSTRАСTIn this wоrk, а new tetrаlоne, 4 R,8-dihуdrоxу-7-(1-hуdrоxуethуl)-6-methуl-1-tetrаlоne (1), wаs isоlаted аnd struсturаllу eluсidаted, аlоng with fоurteen previоuslу identified соmpоunds (2-15) frоm the аeriаl pаrts оf Impаtiens siсulifera grоwing in Vietnаm fоr the first time. The biоlоgiсаl аssауs reveаled thаt the new соmpоund 1 pоssessed prоnоunсed α-gluсоsidаse inhibitоrу асtivitу, with the IС₅₀ vаlue оf 14.19 ± 0.09 µg/mL, whiсh wаs соnsiderаblу strоnger thаn thаt оf the referenсe drug, асаrbоse (IС₅₀ 198.5 ± 6,25 µg/mL). Mоreоver, lignаn 12 demоnstrаted the mоst pоtent inhibitiоn оf NО prоduсtiоn уielding аn IС₅₀ vаlue оf 12.53 ± 0.95 µg/mL.

Several Polygala species have been widely used in folk medicine for the cure of mainly neurological disorders. Polygala vulgaris is one of the polyploid species in the flora of Türkiye. The studies on the dried roots of this species resulted in the isolation of seven sucrose mono- and diesters (1-7), a known lignan glycoside, liriodendrin (8), a xanthone O-glycoside, 7-O-β-glucopyranosyloxy-1-hydroxy-2,3,4-trimethoxyxanthone (9), three previously described tetrasaccharide multiesters fallaxoses C, D and senegose G (10-12), three newly described tetrasaccharide multiesters (vulgaroses A, B and C) (13-15) and two known saponins (polygalasaponin XLIV and E-senegasaponin c) (16-17). The structures of the compounds were determined by spectroscopic methods including 1D-NMR (¹H-NMR,¹³C-NMR, DEPT-135, 1D selective ROESY), 2D-NMR (COSY, HSQC, HSQC-TOCSY, TOCSY, HMBC, NOESY, ROESY) and HRMS.