Pub Date : 2024-09-19DOI: 10.1080/14786419.2024.2405011
Abdelaaty Hamed, Menna El Gaafary, Lydia Fumiko Yamaguchi, Hans Georg Stammler, Layth M Salih, David Ziegler, Tatiana Syrovets, Massuo Jorge Kato
Chromatographic fractionation of CH2Cl2:MeOH (1:1) extract of Coccoloba peltata Schott cultivated in Egypt afforded four compounds, lupeol acetate (1), ent-13-epi-manoyl oxide (2), 5-methoxymethyl-7,8-dimethyltocol (3), and α-tocopherol quinone (4). The planar structures of the isolated compounds were concluded based on HRESIMS and NMR spectroscopy. X-ray crystallography of 2 is reported herein for the first time and its unambiguous absolute configuration was deduced from anomalous dispersion. To the best of our knowledge, this is the first known report on the isolation of compounds 1-4 from this species. Among the isolated compounds, only compound 4 showed a moderate level of cytotoxic activity against six cancer cell lines out of seven cell lines tested.
{"title":"Chemical constituents of <i>Coccoloba peltata</i> Schott leaves and their cytotoxic activities.","authors":"Abdelaaty Hamed, Menna El Gaafary, Lydia Fumiko Yamaguchi, Hans Georg Stammler, Layth M Salih, David Ziegler, Tatiana Syrovets, Massuo Jorge Kato","doi":"10.1080/14786419.2024.2405011","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405011","url":null,"abstract":"<p><p>Chromatographic fractionation of CH<sub>2</sub>Cl<sub>2</sub>:MeOH (1:1) extract of <i>Coccoloba peltata</i> Schott cultivated in Egypt afforded four compounds, lupeol acetate (<b>1</b>), <i>ent</i>-13-<i>epi</i>-manoyl oxide (<b>2</b>), 5-methoxymethyl-7,8-dimethyltocol (<b>3</b>), and <i>α</i>-tocopherol quinone (<b>4</b>). The planar structures of the isolated compounds were concluded based on HRESIMS and NMR spectroscopy. X-ray crystallography of <b>2</b> is reported herein for the first time and its unambiguous absolute configuration was deduced from anomalous dispersion. To the best of our knowledge, this is the first known report on the isolation of compounds <b>1</b>-<b>4</b> from this species. Among the isolated compounds, only compound <b>4</b> showed a moderate level of cytotoxic activity against six cancer cell lines out of seven cell lines tested.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1080/14786419.2024.2405996
Vinothini Gunasekaran, Sathishkumar Palanivel
Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)
发表于《天然产物研究》:前身为《天然产物通讯》(2024 年提前出版)
{"title":"Treatment of oral cancer cells using natural drug fisetin: an effective phytotherapy","authors":"Vinothini Gunasekaran, Sathishkumar Palanivel","doi":"10.1080/14786419.2024.2405996","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405996","url":null,"abstract":"Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1080/14786419.2024.2405865
Estefania Júlia Dierings de Souza, Dianini Hüttner Kringel, Igor Henrique de Lima Costa, Helen Cristina Dos Santos Hackbart, Rufino Fernando Flores Cantillano, Bernardo Ueno, Alvaro Renato Guerra Dias, Elessandra da Rosa Zavareze
Fungal deterioration is a recurring problem in citrus fruits, and the search for natural preservatives has been widely publicised. Therefore, the in vitro antifungal activity of clove, white thyme, tea tree, Eucalyptus citriodora, Eucalyptus staigeriana, green mandarin, sicilian lemon, sweet orange, and bergamot essential oils (EO's) was evaluated against the mycelial growth of Penicillium digitatum isolated from contaminated citrus fruits, by direct contact and volatiles action. In addition, the chemical composition and volatile compounds of the EO's were evaluated by gas chromatography. Clove, white thyme, and Eucalyptus citriodora EO's inhibited 100% of the mycelial growth of P. digitatum by direct contact and volatile action at concentrations ≤ 2 µL/mL. On the other hand, EO's from citrus sources could not inhibit 100% of mycelial growth by any mechanism of action. Thus, the clove, thyme, and Eucalyptus citriodora EO's are promising for developing new ecologically correct products for controlling phytopathogens in citrus fruits.
柑橘类水果经常出现真菌变质的问题,寻找天然防腐剂的呼声很高。因此,研究人员通过直接接触和挥发作用,评估了丁香、白百里香、茶树、柠檬桉、桉树、绿柑橘、西西里柠檬、甜橙和佛手柑精油(EO's)对从受污染柑橘类水果中分离出的数字青霉菌丝体生长的体外抗真菌活性。此外,还通过气相色谱法评估了 EO 的化学成分和挥发性化合物。丁香、白百里香和柠檬桉环氧乙烷通过直接接触和挥发作用,在浓度≤ 2 µL/mL时可100%地抑制地衣蛾菌丝的生长。另一方面,柑橘类环氧乙烷无法通过任何作用机制 100%地抑制菌丝生长。因此,丁香、百里香和柠檬桉环氧乙烷有望开发出生态正确的新产品,用于控制柑橘类水果中的植物病原体。
{"title":"Antifungal potential of essential oils from different botanical sources against <i>Penicillium digitatum</i>: chemical composition and antifungal mechanisms of action by direct contact and volatile.","authors":"Estefania Júlia Dierings de Souza, Dianini Hüttner Kringel, Igor Henrique de Lima Costa, Helen Cristina Dos Santos Hackbart, Rufino Fernando Flores Cantillano, Bernardo Ueno, Alvaro Renato Guerra Dias, Elessandra da Rosa Zavareze","doi":"10.1080/14786419.2024.2405865","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405865","url":null,"abstract":"<p><p>Fungal deterioration is a recurring problem in citrus fruits, and the search for natural preservatives has been widely publicised. Therefore, the <i>in vitro</i> antifungal activity of clove, white thyme, tea tree, <i>Eucalyptus citriodora</i>, <i>Eucalyptus staigeriana</i>, green mandarin, sicilian lemon, sweet orange, and bergamot essential oils (EO's) was evaluated against the mycelial growth of <i>Penicillium digitatum</i> isolated from contaminated citrus fruits, by direct contact and volatiles action. In addition, the chemical composition and volatile compounds of the EO's were evaluated by gas chromatography. Clove, white thyme, and <i>Eucalyptus citriodora</i> EO's inhibited 100% of the mycelial growth of <i>P. digitatum</i> by direct contact and volatile action at concentrations ≤ 2 µL/mL. On the other hand, EO's from citrus sources could not inhibit 100% of mycelial growth by any mechanism of action. Thus, the clove, thyme, and <i>Eucalyptus citriodora</i> EO's are promising for developing new ecologically correct products for controlling phytopathogens in citrus fruits.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1080/14786419.2024.2405010
Ulin Antobelli Basilio-Cortes, Milena M Ramírez-Rodrigues, Melissa A Ramírez-Rodrigues, Daniel González-Mendoza, Olivia Tzintzun-Camacho, Dagoberto Durán-Hernández, Lourdes González-Salitre
This study aimed to evaluate the impact of temperature on the potential extraction of bioactive compounds from aqueous hop extract samples. The main bioactive components were characterised and analysed by LC-MS/MS, FT-IR, phenolic compounds and total flavonoids. Antifungal activity was evaluated in vitro and in vivo in bell peppers. LC-MS/MS analysis demonstrated increases and decreases of bioactive compounds in both extracts depending on the extraction temperature of 25 or 65 °C. The bioactive compounds showed significant changes in the bands between 2786 to 3600 cm-1 and 1022 to 1729 cm-1 in the FT-IR spectrum. The highest antifungal activity against the microorganisms was observed in the EkuanotMT extract at an extraction temperature of 65 °C. The in vivo test with bell peppers presented antifungal activity during five days of evaluation under normal environmental conditions without refrigeration, presenting ≤ 52% of the disease due to F. oxysporum and A. solani.
本研究旨在评估温度对从水性酒花提取物样品中提取生物活性化合物的潜在影响。通过 LC-MS/MS、FT-IR、酚类化合物和总黄酮对主要生物活性成分进行了表征和分析。对甜椒的体外和体内抗真菌活性进行了评估。LC-MS/MS 分析表明,两种提取物中生物活性化合物的增加和减少取决于 25 或 65 °C 的提取温度。在傅立叶变换红外光谱中,生物活性化合物在 2786 至 3600 cm-1 和 1022 至 1729 cm-1 之间的波段有明显变化。在 65 °C 的提取温度下,EkuanotMT 提取物对微生物的抗真菌活性最高。在不冷藏的正常环境条件下,对甜椒进行了为期五天的体内试验,结果表明该提取物具有抗真菌活性,对 F. oxysporum 和 A. solani 疾病的抑制率≤52%。
{"title":"Phytochemical, spectroscopic analysis and antifungal activity on bell peppers of hydrothermal bioactive metabolites of <i>Humulus lupulus</i> L. extracts.","authors":"Ulin Antobelli Basilio-Cortes, Milena M Ramírez-Rodrigues, Melissa A Ramírez-Rodrigues, Daniel González-Mendoza, Olivia Tzintzun-Camacho, Dagoberto Durán-Hernández, Lourdes González-Salitre","doi":"10.1080/14786419.2024.2405010","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405010","url":null,"abstract":"<p><p>This study aimed to evaluate the impact of temperature on the potential extraction of bioactive compounds from aqueous hop extract samples. The main bioactive components were characterised and analysed by LC-MS/MS, FT-IR, phenolic compounds and total flavonoids. Antifungal activity was evaluated <i>in vitro</i> and <i>in vivo</i> in bell peppers. LC-MS/MS analysis demonstrated increases and decreases of bioactive compounds in both extracts depending on the extraction temperature of 25 or 65 °C. The bioactive compounds showed significant changes in the bands between 2786 to 3600 cm<sup>-1</sup> and 1022 to 1729 cm<sup>-1</sup> in the FT-IR spectrum. The highest antifungal activity against the microorganisms was observed in the Ekuanot<sup>MT</sup> extract at an extraction temperature of 65 °C. The <i>in vivo</i> test with bell peppers presented antifungal activity during five days of evaluation under normal environmental conditions without refrigeration, presenting ≤ 52% of the disease due to <i>F. oxysporum</i> and <i>A. solani</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/14786419.2024.2402461
Mohammad Irfan Dar, Anu Gulya, Sageer Abass, Kapil Dev, Rabea Parveen, Sayeed Ahmad, Mohammad Irfan Qureshi
Diabetes mellitus (DM) is a serious health issue and is still one of the major causes of mortality around the globe. Natural products have progressively integrated into modern, advanced medical practices. Phytoconstituents from some medicinal plants have demonstrated therapeutic activity in treating different metabolic disorders and have been used to treat DM and its severe complications. The present review provides details of the major anti-diabetic targets identified in the literature and also provides comprehensive information regarding the therapeutic role of a synergy-based combination of phytoconstituents that functions by controlling specific molecular pathways synchronously by inhibiting certain key regulators involved in the development and progression of DM. The review also implicated the role of oxidative stress in diabetic complications and presented scientific validations of phytochemicals and their synergy-based combination using in vitro and or in vivo approaches.
{"title":"Hallmarks of diabetes mellitus and insights into the therapeutic potential of synergy-based combinations of phytochemicals in reducing oxidative stress-induced diabetic complications.","authors":"Mohammad Irfan Dar, Anu Gulya, Sageer Abass, Kapil Dev, Rabea Parveen, Sayeed Ahmad, Mohammad Irfan Qureshi","doi":"10.1080/14786419.2024.2402461","DOIUrl":"https://doi.org/10.1080/14786419.2024.2402461","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a serious health issue and is still one of the major causes of mortality around the globe. Natural products have progressively integrated into modern, advanced medical practices. Phytoconstituents from some medicinal plants have demonstrated therapeutic activity in treating different metabolic disorders and have been used to treat DM and its severe complications. The present review provides details of the major anti-diabetic targets identified in the literature and also provides comprehensive information regarding the therapeutic role of a synergy-based combination of phytoconstituents that functions by controlling specific molecular pathways synchronously by inhibiting certain key regulators involved in the development and progression of DM. The review also implicated the role of oxidative stress in diabetic complications and presented scientific validations of phytochemicals and their synergy-based combination using <i>in vitro</i> and or <i>in vivo</i> approaches.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/14786419.2024.2404660
Jinrun Dong, Deqiong Niu, Ping Xiang, Zhonghai Dao, Jing Li
Phytochemical investigation of the chloroform extract of the roots of Cynanchum otophyllum (Asclepiadaceae) led to the isolation of a new cardiac aglycone, characterised as Cynanchin A (1), as well as one known cardenolide (2) and nine known C21 steroidal glycosides (3-10), Their structures were established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis. In the present research, the cytotoxic activities of the 11 compounds on five different human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) were evaluated in vitro. Most of the tested compounds showed potent inhibitory activities towards the five cell lines.
{"title":"Chemical constituents with potential cytotoxic activities from <i>Cynanchum otophyllum</i>.","authors":"Jinrun Dong, Deqiong Niu, Ping Xiang, Zhonghai Dao, Jing Li","doi":"10.1080/14786419.2024.2404660","DOIUrl":"https://doi.org/10.1080/14786419.2024.2404660","url":null,"abstract":"<p><p>Phytochemical investigation of the chloroform extract of the roots of <i>Cynanchum otophyllum</i> (Asclepiadaceae) led to the isolation of a new cardiac aglycone, characterised as Cynanchin A (1), as well as one known cardenolide (2) and nine known C21 steroidal glycosides (3-10), Their structures were established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis. In the present research, the cytotoxic activities of the 11 compounds on five different human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) were evaluated <i>in vitro</i>. Most of the tested compounds showed potent inhibitory activities towards the five cell lines.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/14786419.2024.2405878
Valentina Adimurti Kusumaningtyas, Unang Supratman, Putu Teta Prihartini Aryanti, Melina Melina, Lia Dewi Juliawati
In the search for new antibacterial agents from plants, two known compounds (rotenoid and chalcone) were isolated from Tephrosia vogelii Hook.f. (seeds), namely tephrosin (1), and obovatachalcone (...
{"title":"Tephrosin and obovatachalcone with antibacterial activity from Tephrosia vogelii Hook.f","authors":"Valentina Adimurti Kusumaningtyas, Unang Supratman, Putu Teta Prihartini Aryanti, Melina Melina, Lia Dewi Juliawati","doi":"10.1080/14786419.2024.2405878","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405878","url":null,"abstract":"In the search for new antibacterial agents from plants, two known compounds (rotenoid and chalcone) were isolated from Tephrosia vogelii Hook.f. (seeds), namely tephrosin (1), and obovatachalcone (...","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/14786419.2024.2404645
Spandana KJ, Bhagya N, Chandrashekar KR
Fourteen known phenolics (1-14) and ten known flavonoids (15-24) were identified in the hydroalcoholic extract of Clitoria ternatea seeds. Phenolics such as gentisic acid (3), protocatechuic acid (...
{"title":"UHPLC-ESI-ms/ms-based characterisation of phenolics and flavonoids in hydroalcoholic extract of Clitoria ternatea seeds and their cytotoxic potential against breast and pancreatic cancer","authors":"Spandana KJ, Bhagya N, Chandrashekar KR","doi":"10.1080/14786419.2024.2404645","DOIUrl":"https://doi.org/10.1080/14786419.2024.2404645","url":null,"abstract":"Fourteen known phenolics (1-14) and ten known flavonoids (15-24) were identified in the hydroalcoholic extract of Clitoria ternatea seeds. Phenolics such as gentisic acid (3), protocatechuic acid (...","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rotheca serrata (L.) Steane & Mabb. a plant having significant medicinal value is used in treating a fever, rheumatism, inflammation, pain, and malarial fever. Ursolic acid has a five-ringed pentacyclic structure belongs to the family of triterpenoids. It has antioxidant, antitumor, and hepato-protective properties. The method in HPLC was developed on a SHIMADZU, Shimpack ODS (25 cm × 4.6 mm, 5 µm) column. The mobile phase consisted of a 70:25:5 (v/v/v) mixture of methanol, acetonitrile, and 0.02 M ammonium acetate buffer (pH 3.5). A flow rate of 1.2 mL/min and λmax of 215 nm. Ursolic acid from the extract and standard was eluted at the same retention time of 4.1 min. 20-120 µg/mL was the linearity range chosen and was found to be linear (R2=0.996). The value of LOD was 0.85 µg/mL and LOQ was 1.96 µg/mL. The method for analysis of ursolic was found to be accurate with good repeatability.
{"title":"Determination of ursolic acid in ethanolic extract of <i>Rotheca serrata</i> (L.) Steane & Mabb. by HPLC method.","authors":"Sumedha Kundu, Rajeshwari Selvaraj, Kalyani Reddy, Hemanth Vikram Pr, Bannimath Gurupadayya","doi":"10.1080/14786419.2024.2405007","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405007","url":null,"abstract":"<p><p><i>Rotheca serrata</i> (L.) Steane & Mabb. a plant having significant medicinal value is used in treating a fever, rheumatism, inflammation, pain, and malarial fever. Ursolic acid has a five-ringed pentacyclic structure belongs to the family of triterpenoids. It has antioxidant, antitumor, and hepato-protective properties. The method in HPLC was developed on a SHIMADZU, Shimpack ODS (25 cm × 4.6 mm, 5 µm) column. The mobile phase consisted of a 70:25:5 (v/v/v) mixture of methanol, acetonitrile, and 0.02 M ammonium acetate buffer (pH 3.5). A flow rate of 1.2 mL/min and λ<sub>max</sub> of 215 nm. Ursolic acid from the extract and standard was eluted at the same retention time of 4.1 min. 20-120 µg/mL was the linearity range chosen and was found to be linear (<i>R</i><sup>2</sup>=0.996). The value of LOD was 0.85 µg/mL and LOQ was 1.96 µg/mL. The method for analysis of ursolic was found to be accurate with good repeatability.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/14786419.2024.2405997
Lekha Sree Venkatesan, Sathishkumar Palanivel
{"title":"Therapeutic role of natural drug kaempferol in head and neck cancer treatment.","authors":"Lekha Sree Venkatesan, Sathishkumar Palanivel","doi":"10.1080/14786419.2024.2405997","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405997","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}