Pub Date : 2026-02-01DOI: 10.1080/14786419.2025.2477807
Ravi S Manhas , Neha Sharma , Safeya Begum , Yedukondalu Nalli , Asha Chaubey
A new obscurolide, (3 R)-obscurolide A (5) and four previously identified metabolites streptalbonin F (1), chartreusin (2), TAN 1364B (3) and streptalbonin G (4) were isolated from Streptomyces chartreusis SA-7, obtained from soil of the North Western Himalayas. The structure of new compound (3 R)-obscurolide A (5) was elucidated by spectroscopic data analysis, including 1D and 2D NMR, and HR-ESI-MS, while the known compounds (1–4) were identified by comparing their spectral data with the literature. Notably, chartreusin (2) is a well-known antimicrobial agent with broad-spectrum activity, while the other compounds had been reported to display moderate antimicrobial effects against various test strains.
{"title":"(3R)-obscurolide A: a new obscurolide from Streptomyces chartreusis SA-7 isolated from soil of the North Western Himalayas","authors":"Ravi S Manhas , Neha Sharma , Safeya Begum , Yedukondalu Nalli , Asha Chaubey","doi":"10.1080/14786419.2025.2477807","DOIUrl":"10.1080/14786419.2025.2477807","url":null,"abstract":"<div><div>A new obscurolide, (3 <em>R</em>)-obscurolide A (<strong>5</strong>) and four previously identified metabolites streptalbonin F (<strong>1</strong>), chartreusin (<strong>2</strong>), TAN 1364B (<strong>3</strong>) and streptalbonin G (<strong>4</strong>) were isolated from <em>Streptomyces chartreusis</em> SA-7, obtained from soil of the North Western Himalayas. The structure of new compound (3 <em>R</em>)-obscurolide A (<strong>5</strong>) was elucidated by spectroscopic data analysis, including 1D and 2D NMR, and HR-ESI-MS, while the known compounds (<strong>1</strong>–<strong>4</strong>) were identified by comparing their spectral data with the literature. Notably, chartreusin (<strong>2</strong>) is a well-known antimicrobial agent with broad-spectrum activity, while the other compounds had been reported to display moderate antimicrobial effects against various test strains.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 901-908"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical and biological properties of a novel 1,4-naphtoquinone-chromene derivative synthesised from perillaldehyde, major compound of Ammodaucus leucotrichus essential oil were evaluated. The obtained product was efficiently prepared through a tandem hemisynthesis reaction under environmentally friendly conditions (solvent-free, moderate temperature) via Knoevenagel condensation and Michael addition reactions, using 4-pyrolidinopyridine organobase as a catalyst. The structure of newly synthesised product (HRP63) was characterised using FTIR,1H,13C and 2D NMR spectroscopy. Furthermore, HRP63 was assessed for its antimicrobial activity and its potential interaction with different receptors implicated in psoriasis. The obtained results revealed moderate antibacterial activity. In silico molecular docking studies revealed significant inhibitory interaction of HRP63 against TNF-α, TLR7, TLR2, and TNFR1 receptors with inhibition constants ranging from 0.74 to 0.17 µM, and free binding energies of the complexes obtained between −8.36 and −9.24 kcal/M. These results will guide future studies aimed at exploit the pharmacological profile of HRP63 product.
{"title":"Organobase-catalyzed tandem green hemisynthesis of novel 1,4-naphthoquinone-chromene derivative from Ammodaucus leucotrichus (Cosson & Durieu) essential oil; antimicrobial activity and in silico exploration against psoriasis-associated receptors","authors":"Ridha Hassaine , Nadia Taibi , Ahmed Djafri , Sonia Ouraghi , Imad Abdelhamid El Haci , Abdelghani Bouchama , Houria Lakhdari , Sofiane Negadi , Rachid Amraoui , Amel Kaced , Kenza Hasnaoui , Wissem Ouzit , Noureddine Choukchou-Braham , Mohammed Benabdellah","doi":"10.1080/14786419.2025.2477811","DOIUrl":"10.1080/14786419.2025.2477811","url":null,"abstract":"<div><div>Chemical and biological properties of a novel 1,4-naphtoquinone-chromene derivative synthesised from perillaldehyde, major compound of <em>Ammodaucus leucotrichus</em> essential oil were evaluated. The obtained product was efficiently prepared through a tandem hemisynthesis reaction under environmentally friendly conditions (solvent-free, moderate temperature) <em>via</em> Knoevenagel condensation and Michael addition reactions, using 4-pyrolidinopyridine organobase as a catalyst. The structure of newly synthesised product (<em>HRP63)</em> was characterised using FTIR,<sup>1</sup>H,<sup>13</sup>C and 2D NMR spectroscopy. Furthermore, <em>HRP63</em> was assessed for its antimicrobial activity and its potential interaction with different receptors implicated in psoriasis. The obtained results revealed moderate antibacterial activity. <em>In silico</em> molecular docking studies revealed significant inhibitory interaction of <em>HRP63</em> against TNF-α, TLR7, TLR2, and TNFR1 receptors with inhibition constants ranging from 0.74 to 0.17 µM, and free binding energies of the complexes obtained between −8.36 and −9.24 kcal/M. These results will guide future studies aimed at exploit the pharmacological profile of <em>HRP63</em> product.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 909-914"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2025.2477219
Claudio Frezza , Fabio Sciubba , Ilaria Serafini , Elisa Mastellone , Luigi Scipione , Paola Di Matteo , Rita Petrucci , Daniela De Vita
The continuation of the phytochemical analysis to determine the alkaloid content of Vinca difformis subsp. sardoa Stearn, led to the isolation of the further compound vincamajine (1) which was reported from the species for the first time during this study. Its structure was established by means of extensive NMR, IR and MS analyses which are completely reported in this paper for the first time. In addition, the first chemophenetic evaluation about this compound was also carried out evidencing some important results which were fully described and discussed in this paper.
{"title":"A new isolation of vincamajine from Vinca difformis subsp. sardoa Stearn","authors":"Claudio Frezza , Fabio Sciubba , Ilaria Serafini , Elisa Mastellone , Luigi Scipione , Paola Di Matteo , Rita Petrucci , Daniela De Vita","doi":"10.1080/14786419.2025.2477219","DOIUrl":"10.1080/14786419.2025.2477219","url":null,"abstract":"<div><div>The continuation of the phytochemical analysis to determine the alkaloid content of <em>Vinca difformis</em> subsp. <em>sardoa</em> Stearn, led to the isolation of the further compound vincamajine (<strong>1</strong>) which was reported from the species for the first time during this study. Its structure was established by means of extensive NMR, IR and MS analyses which are completely reported in this paper for the first time. In addition, the first chemophenetic evaluation about this compound was also carried out evidencing some important results which were fully described and discussed in this paper.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 896-900"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2417353
Yinping Jin , Yunzhe Yu , Chong Liu , Zihao Zhao , Zheng Li , Shifeng Pang , Siwei Qiao , Hao Zhang
The contents of 57 ginsenosides were measured in American ginseng roots collected from a single population grown in Jilin. Ginsenoside contents and compositions varied significantly among the population. The most abundant ginsenoside within the American ginseng root and by population was either Rg1 or Re, followed by Rb1, mal-Rb1, Rd, Rc, pseudoginsenoside F11, Ro, and gypenoside XVII. According to the relative contents of Rg1 and Re, the population was grouped into two chemotypes, and there were significant differences in ginsenoside profiles between them. The contents of protopanaxadiol-type ginsenosides were relatively stable. The rate-limiting enzymes of malonyl ginsenosides biosynthesis were located in front of their corresponding neutral ginsenosides. The regulatory sites of the oleanolic acid-type ginsenosides biosynthetic pathway were in front of the β-amyrin.
研究人员测定了从吉林市单一人参种群中采集的西洋参根中 57 种人参皂苷的含量。不同群体的人参皂苷含量和成分差异显著。西洋参根中含量最高的人参皂甙是Rg1或Re，其次是Rb1、mal-Rb1、Rd、Rc、假人参皂甙F11、Ro和西洋参皂甙XVII。根据 Rg1 和 Re 的相对含量，该群体被分为两个化学类型，它们之间的人参皂苷含量存在显著差异。原人参二醇型人参皂苷的含量相对稳定。丙二酰人参皂苷生物合成的限速酶位于相应中性人参皂苷的前端。齐墩果酸型人参皂苷生物合成途径的调控位点位于β-amyrin的前方。
{"title":"Variation in ginsenoside content and composition within the American ginseng population","authors":"Yinping Jin , Yunzhe Yu , Chong Liu , Zihao Zhao , Zheng Li , Shifeng Pang , Siwei Qiao , Hao Zhang","doi":"10.1080/14786419.2024.2417353","DOIUrl":"10.1080/14786419.2024.2417353","url":null,"abstract":"<div><div>The contents of 57 ginsenosides were measured in American ginseng roots collected from a single population grown in Jilin. Ginsenoside contents and compositions varied significantly among the population. The most abundant ginsenoside within the American ginseng root and by population was either Rg<sub>1</sub> or Re, followed by Rb<sub>1</sub>, mal-Rb<sub>1</sub>, Rd, Rc, pseudoginsenoside F<sub>11</sub>, Ro, and gypenoside XVII. According to the relative contents of Rg<sub>1</sub> and Re, the population was grouped into two chemotypes, and there were significant differences in ginsenoside profiles between them. The contents of protopanaxadiol-type ginsenosides were relatively stable. The rate-limiting enzymes of malonyl ginsenosides biosynthesis were located in front of their corresponding neutral ginsenosides. The regulatory sites of the oleanolic acid-type ginsenosides biosynthetic pathway were in front of the <em>β</em>-amyrin.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 642-646"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study aimed to isolate, purify and optimise tyrosinase from banana peel waste for industrial use. Tyrosinase was extracted from banana peel using phosphate buffer. Purification initiated with centrifugation followed by ammonium sulphate precipitation. Further purification and characterisation was done through gel filtration. Bradford assay was used to determine the protein concentration. Enzyme activity of each sample was measured using tyrosinase activity assay. The pH and temperature optimisation of tyrosinase were also obtained. Results indicated that fractions obtained through ammonium sulphate precipitation at 70% saturation showed more activity than that of crude extract and 35% saturated fractions. Gel filtration column results showed that fraction number 17 &18 have maximum activity. Tyrosinase showed maximum activity at pH 7.0; 37 °C. Comparison between industrially purified and lab-isolated enzyme showed that both have similar optimum pH and temperature. It can be concluded that banana peel can be a source for synthesis of tyrosinase.
{"title":"Isolation, identification and optimization for tyrosinase production by banana peel waste for industrial application","authors":"Raheela Jabeen , Ume Habiba , Tahmina Mustafa , Tayyeba Rehman","doi":"10.1080/14786419.2024.2426209","DOIUrl":"10.1080/14786419.2024.2426209","url":null,"abstract":"<div><div>The study aimed to isolate, purify and optimise tyrosinase from banana peel waste for industrial use. Tyrosinase was extracted from banana peel using phosphate buffer. Purification initiated with centrifugation followed by ammonium sulphate precipitation. Further purification and characterisation was done through gel filtration. Bradford assay was used to determine the protein concentration. Enzyme activity of each sample was measured using tyrosinase activity assay. The pH and temperature optimisation of tyrosinase were also obtained. Results indicated that fractions obtained through ammonium sulphate precipitation at 70% saturation showed more activity than that of crude extract and 35% saturated fractions. Gel filtration column results showed that fraction number 17 &18 have maximum activity. Tyrosinase showed maximum activity at pH 7.0; 37 °C. Comparison between industrially purified and lab-isolated enzyme showed that both have similar optimum pH and temperature. It can be concluded that banana peel can be a source for synthesis of tyrosinase.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 849-853"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2422524
Zainab Ngaini , Mohamad Asri Jefferi, Saba Farooq
The exploitation of naturally derived drugs can become a replacement for ineffective drugs due to the relentless antimicrobial resistance. A series of natural-product-based coumarin-chalcones (4a-4i) were synthesised via facile Steglich esterification. The coumarin-chalcones (4a-4i) showed effective inhibition against P. aeruginosa (7–13 mm) and E. coli (8–12 mm) in comparison to the standard drug ampicillin and coumarin alone. Compounds 4b and 4g exhibited the highest inhibition zone against P. aeruginosa (13 mm) and E. coli (12 mm) respectively. The hybridisation of chalcone in the coumarin network introduced active C = CH, C = O and C-O moieties, contributing to significant microbial inhibition. The molecular docking of 4b exhibited the highest binding affinity −10.1 kcal/mol as compared to 4a, 4c and 4g −9.2 kcal/mol, −9.2 kcal/mol and −9.1 kcal/mol respectively. The ADMET studies also supported natural-product-based coumarin-chalcones as suitable drug candidates. This study is noteworthy for coumarin-based drug development in the medicinal field.
{"title":"Synthesis, molecular docking, ADMET studies and antimicrobial activities of coumarin-chalcone hybrid derivatives","authors":"Zainab Ngaini , Mohamad Asri Jefferi, Saba Farooq","doi":"10.1080/14786419.2024.2422524","DOIUrl":"10.1080/14786419.2024.2422524","url":null,"abstract":"<div><div>The exploitation of naturally derived drugs can become a replacement for ineffective drugs due to the relentless antimicrobial resistance. A series of natural-product-based coumarin-chalcones (<strong>4a-4i</strong>) were synthesised <em>via</em> facile Steglich esterification. The coumarin-chalcones (<strong>4a-4i</strong>) showed effective inhibition against <em>P. aeruginosa</em> (7–13 mm) and <em>E. coli</em> (8–12 mm) in comparison to the standard drug ampicillin and coumarin alone. Compounds <strong>4b</strong> and <strong>4g</strong> exhibited the highest inhibition zone against <em>P. aeruginosa</em> (13 mm) and <em>E. coli</em> (12 mm) respectively. The hybridisation of chalcone in the coumarin network introduced active C = CH, C = O and C-O moieties, contributing to significant microbial inhibition. The molecular docking of <strong>4b</strong> exhibited the highest binding affinity −10.1 kcal/mol as compared to <strong>4a</strong>, <strong>4c</strong> and <strong>4g</strong> −9.2 kcal/mol, −9.2 kcal/mol and −9.1 kcal/mol respectively. The ADMET studies also supported natural-product-based coumarin-chalcones as suitable drug candidates. This study is noteworthy for coumarin-based drug development in the medicinal field.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 697-706"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2425808
Qing Bu , Qi-Bin Yang , Zeng-Yue Ge , Ze-Xiong Shi , Lin-Fu Liang
There has been no phytochemical or and pharmacological report of the Chinese endemic plant Ophiorrhiza puffii till now. At present, seven structurally diverse compounds were obtained, including six triterpenoids (1–6) and one anthraquinone (7). Interestingly, 1–6 furnished three distinct carbon skeletons. Additionally, these phytochemical constituents showed multiple health-promoting effects. Triterpene 3 displayed considerable tyrosinase inhibitory activity (IC50 = 5.42 μM). Components 4 and 5 demonstrated significant antioxidant activity (IC50 = 4.23 and 2.03 mM, respectively). Meanwhile, compounds 2 and 5 exhibited moderate α-glucosidase inhibitory activity (IC50 = 0.89 and 0.72 mM, respectively). Moreover, the binding mechanisms for bioactive compounds 2, 3 and 5 and the corresponding α-glucosidase and tyrosinase proteins were preliminarily inspected by molecular docking experiments. This study filled up the knowledge gap of the unexplored chemical and biological profiles of secondary metabolites from the plant O. puffii for the first time.
{"title":"Phytochemicals and health-promoting evaluations of Ophiorrhiza puffii, a chinese endemic plant","authors":"Qing Bu , Qi-Bin Yang , Zeng-Yue Ge , Ze-Xiong Shi , Lin-Fu Liang","doi":"10.1080/14786419.2024.2425808","DOIUrl":"10.1080/14786419.2024.2425808","url":null,"abstract":"<div><div>There has been no phytochemical or and pharmacological report of the Chinese endemic plant <em>Ophiorrhiza puffii</em> till now. At present, seven structurally diverse compounds were obtained, including six triterpenoids (<strong>1</strong>–<strong>6</strong>) and one anthraquinone (<strong>7</strong>). Interestingly, <strong>1</strong>–<strong>6</strong> furnished three distinct carbon skeletons. Additionally, these phytochemical constituents showed multiple health-promoting effects. Triterpene <strong>3</strong> displayed considerable tyrosinase inhibitory activity (IC<sub>50</sub> = 5.42 μM). Components <strong>4</strong> and <strong>5</strong> demonstrated significant antioxidant activity (IC<sub>50</sub> = 4.23 and 2.03 mM, respectively). Meanwhile, compounds <strong>2</strong> and <strong>5</strong> exhibited moderate α-glucosidase inhibitory activity (IC<sub>50</sub> = 0.89 and 0.72 mM, respectively). Moreover, the binding mechanisms for bioactive compounds <strong>2</strong>, <strong>3</strong> and <strong>5</strong> and the corresponding α-glucosidase and tyrosinase proteins were preliminarily inspected by molecular docking experiments. This study filled up the knowledge gap of the unexplored chemical and biological profiles of secondary metabolites from the plant <em>O. puffii</em> for the first time.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 786-790"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cucumis melo var. agrestis (Naudin) is an important wild crop that belongs to the family Cucurbitaceae. Fruits possess digestive, stomachic, vermifuge and febrifuge properties and possess analgesic, antioxidant, antibacterial and anti-inflammatory activities. Current research is aimed at screening diverse phytoconstituents present in the fruit extract of wild melon (C. melo var. agrestis) with the technique of high-performance liquid chromatography (HPLC). Our outcomes showed that fruit extract of C. melo var. agrestis has various phytochemicals such as glycosides, alkaloids, phenols, flavonoids, saponins, tannins, proteins, amino acids and carbohydrates. HPLC analysis revealed that naringenin and catechin were reported to have the highest concentrations among the all studied accessions. PCA and HCA multivariant analysis showed that, first two principal components, i.e. PC1 and PC2 contributed to 54.87% of the variation, where maximum loadings were from apigenin, trailed by gallic acid, rutin, and catechol.
{"title":"Comparative metabolomics-based screening of fruit extracts of less-known melon (Cucumis melo var. agrestis) accessions collected from dry terrain of North India by using HPLC–DAD","authors":"Chanchal Sharma , Jyoti Rani , Manish Kapoor , Navneet Kaur , Sandeep Gawdiya , Saroj Kumar Pradhan","doi":"10.1080/14786419.2024.2424398","DOIUrl":"10.1080/14786419.2024.2424398","url":null,"abstract":"<div><div><em>Cucumis melo var. agrestis</em> (Naudin) is an important wild crop that belongs to the family Cucurbitaceae. Fruits possess digestive, stomachic, vermifuge and febrifuge properties and possess analgesic, antioxidant, antibacterial and anti-inflammatory activities. Current research is aimed at screening diverse phytoconstituents present in the fruit extract of wild melon (<em>C. melo</em> var. <em>agrestis</em>) with the technique of high-performance liquid chromatography (HPLC). Our outcomes showed that fruit extract of <em>C. melo var. agrestis</em> has various phytochemicals such as glycosides, alkaloids, phenols, flavonoids, saponins, tannins, proteins, amino acids and carbohydrates. HPLC analysis revealed that naringenin and catechin were reported to have the highest concentrations among the all studied accessions. PCA and HCA multivariant analysis showed that, first two principal components, <em>i.e.</em> PC1 and PC2 contributed to 54.87% of the variation, where maximum loadings were from apigenin, trailed by gallic acid, rutin, and catechol.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 714-722"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2025.2611424
Ijaz Hussain, Azhar Rasul, Mudassir Hassan, Ravi Rawat, Yusuf Tutar
Scientific research has identified lariciresinol among lignan types, which shows potential against cancer development and bacterial infections in addition to serving as an antioxidant that affects oestrogen activity while blocking inflammation. The review analyses the detailed medical and biological properties of lariciresinol. The two Brassicaceae plant genera Isatis indigotica and Brassica oleracea contain this substance, which exists in various plant types. The compound demonstrated anticancer properties through its mechanisms of stopping cancer cell multiplication and triggering programmed cell death. Recent research found that lariciresinol can block the function of the virus that causes COVID-19 by reducing its ability to enter the cells and proliferate. Lariciresinol antiviral actions have been shown to reduce RNA and viral protein production. The diverse impacts indicate that lariciresinol is a potential compound for novel health solutions and future therapeutic innovations.
{"title":"Lariciresinol: a potent natural compound with diverse therapeutic and health benefits.","authors":"Ijaz Hussain, Azhar Rasul, Mudassir Hassan, Ravi Rawat, Yusuf Tutar","doi":"10.1080/14786419.2025.2611424","DOIUrl":"https://doi.org/10.1080/14786419.2025.2611424","url":null,"abstract":"<p><p>Scientific research has identified lariciresinol among lignan types, which shows potential against cancer development and bacterial infections in addition to serving as an antioxidant that affects oestrogen activity while blocking inflammation. The review analyses the detailed medical and biological properties of lariciresinol. The two Brassicaceae plant genera <i>Isatis indigotica</i> and <i>Brassica oleracea</i> contain this substance, which exists in various plant types. The compound demonstrated anticancer properties through its mechanisms of stopping cancer cell multiplication and triggering programmed cell death. Recent research found that lariciresinol can block the function of the virus that causes COVID-19 by reducing its ability to enter the cells and proliferate. Lariciresinol antiviral actions have been shown to reduce RNA and viral protein production. The diverse impacts indicate that lariciresinol is a potential compound for novel health solutions and future therapeutic innovations.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2424399
Qianyu Chen , Yingxiong Ma , Zhaoyue Dong , Bing Xu , Guowei Wang , Xiaozhong Lan , Zhihua Liao , Min Chen
Two previously undescribed triterpenoids, herpetosin A (1) and herpetosin B (2), together with two known compounds, cucurbitacin B (3) and dihydrocucurbitacin E (4), were isolated from the seeds of Herpetospermum pedunculosum. Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound 1 featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system. Among all the isolates, compound 4 exhibited anti-proliferative effect with IC50 values of 4.5 ± 0.1 μM against A549 cells, 8.2 ± 0.5 μM against MDA-MB-231 cells, and 2.4 ± 0.3 μM against HepG2 cells, respectively.
{"title":"Herpetosin A, a nor-cucurbitane triterpenoid with a 5/6/6/5 ring system from Herpetospermum pedunculosum","authors":"Qianyu Chen , Yingxiong Ma , Zhaoyue Dong , Bing Xu , Guowei Wang , Xiaozhong Lan , Zhihua Liao , Min Chen","doi":"10.1080/14786419.2024.2424399","DOIUrl":"10.1080/14786419.2024.2424399","url":null,"abstract":"<div><div>Two previously undescribed triterpenoids, herpetosin A (<strong>1</strong>) and herpetosin B (<strong>2</strong>), together with two known compounds, cucurbitacin B (<strong>3</strong>) and dihydrocucurbitacin E (<strong>4</strong>), were isolated from the seeds of <em>Herpetospermum pedunculosum.</em> Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound <strong>1</strong> featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system. Among all the isolates, compound <strong>4</strong> exhibited anti-proliferative effect with IC<sub>50</sub> values of 4.5 ± 0.1 <em>μ</em>M against A549 cells, 8.2 ± 0.5 <em>μ</em>M against MDA-MB-231 cells, and 2.4 ± 0.3 <em>μ</em>M against HepG2 cells, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 723-729"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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