Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2417839
Xianglong Zhu , Songtao Wang , Yongxiang Song , Ting Chen , Yan Yan
Glycoabyssomicin A (1), a new type of abyssomicin containing a sugar unit, was isolated from the deep-sea derived Streptomyces koyangensis SCSIO 5802 guided by LC-MS. The structure of 1 was elucidated by HR-ESI-MS, 1D-NMR (1H,13C NMR), 2D-NMR (HSQC, COSY, HMBC, NOESY), and TFA hydrolysis and acetylation reactions. In the antibacterial activities evaluation against a series of gram-positive and gram-negative bacteria, it showed inactive at the concentration of 10 μg per filter paper disc. This finding would broaden the way for discovery of more lead compounds of abyssomicins.
{"title":"LC-MS guided discovery of a new type of abyssomicin, glycoabyssomicin A, from a deep-sea derived Streptomyces","authors":"Xianglong Zhu , Songtao Wang , Yongxiang Song , Ting Chen , Yan Yan","doi":"10.1080/14786419.2024.2417839","DOIUrl":"10.1080/14786419.2024.2417839","url":null,"abstract":"<div><div>Glycoabyssomicin A (<strong>1</strong>), a new type of abyssomicin containing a sugar unit, was isolated from the deep-sea derived <em>Streptomyces koyangensis</em> SCSIO 5802 guided by LC-MS. The structure of <strong>1</strong> was elucidated by HR-ESI-MS, 1D-NMR (<sup>1</sup>H,<sup>13</sup>C NMR), 2D-NMR (HSQC, COSY, HMBC, NOESY), and TFA hydrolysis and acetylation reactions. In the antibacterial activities evaluation against a series of gram-positive and gram-negative bacteria, it showed inactive at the concentration of 10 μg per filter paper disc. This finding would broaden the way for discovery of more lead compounds of abyssomicins.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 660-665"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A previously unreported oleanane triterpenoid, β-amyrin heptadecanoate (1), was isolated from the leaves of Thai Averrhoa bilimbi (Oxalidaceae), along with five known compounds, β-amyrin (2), β-sitosterol (3), β-sitosterol-D-glucoside (4), β-sitosteryl oleate (5), and α-tocopherol (6). Their structures were elucidated through spectroscopic analysis, including extensive NMR and HRESIMS, and by comparison with the previous literature. All isolated compounds were evaluated for their α-glucosidase inhibitory and cytotoxic activities. Compound 6 exhibited the highest α-glucosidase inhibition (IC50 of 0.72 ± 1.02 µM), significantly outperforming the standard acarbose (IC50 of 82.00 ± 0.24 μM). Furthermore, compound 4 demonstrated the most potent cytotoxicity against HeLa cells (IC50 of 34.92 ± 0.45 μM), while compound 3 exhibited the strongest cytotoxicity towards A549 cells (IC50 of 9.17 ± 0.30 μM). Additionally, a molecular docking study was conducted on the active α-glucosidase inhibitors to estimate their binding affinities and to identify the ligand-binding sites within the enzyme.
{"title":"β-amyrin heptadecanoate, a new oleanane triterpenoid with α-glucosidase inhibitory and cytotoxic activities from the leaves of Averrhoa bilimbi L.","authors":"Le-Thuy-Thuy-Trang Hoang , Phan-Si-Nguyen Dong , Van-Kieu Nguyen , Vo Thi Minh Thao , Rico Ramadhan , Rumpa Jutakanoke , Jirapast Sichaem","doi":"10.1080/14786419.2024.2425045","DOIUrl":"10.1080/14786419.2024.2425045","url":null,"abstract":"<div><div>A previously unreported oleanane triterpenoid, <em>β</em>-amyrin heptadecanoate (<strong>1</strong>), was isolated from the leaves of Thai <em>Averrhoa bilimbi</em> (Oxalidaceae), along with five known compounds, <em>β</em>-amyrin (<strong>2</strong>), <em>β</em>-sitosterol (<strong>3</strong>), <em>β</em>-sitosterol-D-glucoside (<strong>4</strong>), <em>β</em>-sitosteryl oleate (<strong>5</strong>), and <em>α</em>-tocopherol (<strong>6</strong>). Their structures were elucidated through spectroscopic analysis, including extensive NMR and HRESIMS, and by comparison with the previous literature. All isolated compounds were evaluated for their <em>α</em>-glucosidase inhibitory and cytotoxic activities. Compound <strong>6</strong> exhibited the highest <em>α</em>-glucosidase inhibition (IC<sub>50</sub> of 0.72 ± 1.02 <em>µ</em>M), significantly outperforming the standard acarbose (IC<sub>50</sub> of 82.00 ± 0.24 <em>μ</em>M). Furthermore, compound <strong>4</strong> demonstrated the most potent cytotoxicity against HeLa cells (IC<sub>50</sub> of 34.92 ± 0.45 <em>μ</em>M), while compound <strong>3</strong> exhibited the strongest cytotoxicity towards A549 cells (IC<sub>50</sub> of 9.17 ± 0.30 <em>μ</em>M). Additionally, a molecular docking study was conducted on the active <em>α</em>-glucosidase inhibitors to estimate their binding affinities and to identify the ligand-binding sites within the enzyme.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 737-745"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2425798
Mohaddeseh Nobarirezaeyeh , Hafize Yuca , Bilge Aydın , Ayşe Civaş , Songül Karakaya , Mehmet Karadayı , Abdussamed Yasin Demir , Mehmet Bona , Bilal Yılmaz , Gamze Göger , Muhammed Ziya Şahinöz , Elif Beyza Özer , Enes Tekman , Zühal Güvenalp , Ayşe Mine Gençler Özkan
The study investigated the antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from Centaurea amanicola and C. antitauri (Asteraceae). Methanol extracts were analysed for phenolic and fatty oil contents. Major components of fatty oils were identified, including methyl hexadecanoate (48.30%) and heptacosane (22.13%) in C. antitauri, and methyl hexadecanoate (16.29%) and methyl linoleate (13.55%) in C. amanicola. The highest α-amylase inhibition was observed in hexane extracts of both species with 55.53% and 41.57% inhibition values, respectively. Antioxidant activity, measured by ABTS•+ and DPPH• scavenging, varied among extracts, with notable efficacy in C. antitauri dichloromethane extract and C. amanicola ethyl acetate extract. The dichloromethane extract of C. antitauri demonstrated effectiveness against Candida albicans with MIC= 156.25 µg/mL. Importantly, all extracts were found to be genotoxicity-safe. Overall, the findings highlight the potential of these extracts for various medicinal applications, particularly in managing diabetes and combating microbial infections.
本研究调查了从菊科植物半枝莲（Centaurea amanicola）和抗陶醉草（C. antitauri）中提取的提取物的抗糖尿病、抗菌、抗氧化和基因毒性活性。对甲醇提取物进行了酚类和脂肪油含量分析。确定了脂肪油的主要成分，包括 C. antitauri 的十六酸甲酯（48.30%）和七烷（22.13%），以及 C. amanicola 的十六酸甲酯（16.29%）和亚油酸甲酯（13.55%）。两个物种的己烷提取物对α-淀粉酶的抑制率最高，分别为 55.53% 和 41.57%。通过 ABTS-+ 和 DPPH- 清除率测定的抗氧化活性在不同提取物中存在差异，其中 C. antitauri 的二氯甲烷提取物和 C. amanicola 的乙酸乙酯提取物具有显著的功效。C. antitauri 的二氯甲烷萃取物对白色念珠菌有效，MIC= 156.25 µg/mL。重要的是，所有提取物的基因毒性都是安全的。总之，研究结果凸显了这些提取物在各种医药应用方面的潜力，尤其是在控制糖尿病和抗微生物感染方面。
{"title":"Phytochemical evaluation via GC-MS and LC-MS/MS: a comprehensive study of antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from endemic species Centaurea amanicola Hub.-Mor. and C. antitauri Hayek (Asteraceae)","authors":"Mohaddeseh Nobarirezaeyeh , Hafize Yuca , Bilge Aydın , Ayşe Civaş , Songül Karakaya , Mehmet Karadayı , Abdussamed Yasin Demir , Mehmet Bona , Bilal Yılmaz , Gamze Göger , Muhammed Ziya Şahinöz , Elif Beyza Özer , Enes Tekman , Zühal Güvenalp , Ayşe Mine Gençler Özkan","doi":"10.1080/14786419.2024.2425798","DOIUrl":"10.1080/14786419.2024.2425798","url":null,"abstract":"<div><div>The study investigated the antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from <em>Centaurea amanicola</em> and <em>C. antitauri</em> (Asteraceae). Methanol extracts were analysed for phenolic and fatty oil contents. Major components of fatty oils were identified, including methyl hexadecanoate (48.30%) and heptacosane (22.13%) in <em>C. antitauri</em>, and methyl hexadecanoate (16.29%) and methyl linoleate (13.55%) in <em>C. amanicola</em>. The highest α-amylase inhibition was observed in hexane extracts of both species with 55.53% and 41.57% inhibition values, respectively. Antioxidant activity, measured by ABTS<sup>•+</sup> and DPPH<sup>•</sup> scavenging, varied among extracts, with notable efficacy in <em>C. antitauri</em> dichloromethane extract and <em>C. amanicola</em> ethyl acetate extract. The dichloromethane extract of <em>C. antitauri</em> demonstrated effectiveness against <em>Candida albicans</em> with MIC= 156.25 µg/mL. Importantly, all extracts were found to be genotoxicity-safe. Overall, the findings highlight the potential of these extracts for various medicinal applications, particularly in managing diabetes and combating microbial infections.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 776-785"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2427811
Van Loc Tran , The Anh Nguyen , Nguyen Tran Dang , Thi Phuong Thao Tran , Tuan Anh Tran , Van Sung Tran , Van Chien Tran
The structural modification of madecassic acid focused on the contraction of the six-membered A-ring to a five-membered ring, combined with the dehydration of 6-OH to form a new double bond and formation of the esterification or amidation at C-28. The synthesised structures were identified based on the analysis of their NMR and EIS-MS data. Eighteen new madecassic acid analogues were tested in vitro for their cytotoxicity against three cancer cell lines, including human mouth carcinoma (KB), human hepatocellular carcinoma (HepG2), and human lung carcinoma (A549) using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Among them, compounds 5 and 12 exhibited potent and selective cytotoxic activity in KB and HepG2 cell lines, with IC50 values ranging from 3.57 to 6.32 µM. The results also indicated that analogues with a 5-membered A-ring containing an α,β-unsaturated aldehyde esterified at C-23 showed a decrease in their cytotoxic activity compared to precursors in the tested cancer cells.
{"title":"Madecassic acid analogues with a five-membered A-ring and their cytotoxic activity","authors":"Van Loc Tran , The Anh Nguyen , Nguyen Tran Dang , Thi Phuong Thao Tran , Tuan Anh Tran , Van Sung Tran , Van Chien Tran","doi":"10.1080/14786419.2024.2427811","DOIUrl":"10.1080/14786419.2024.2427811","url":null,"abstract":"<div><div>The structural modification of madecassic acid focused on the contraction of the six-membered A-ring to a five-membered ring, combined with the dehydration of 6-OH to form a new double bond and formation of the esterification or amidation at C-28. The synthesised structures were identified based on the analysis of their NMR and EIS-MS data. Eighteen new madecassic acid analogues were tested <em>in vitro</em> for their cytotoxicity against three cancer cell lines, including human mouth carcinoma (KB), human hepatocellular carcinoma (HepG2), and human lung carcinoma (A549) using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Among them, compounds <strong>5</strong> and <strong>12</strong> exhibited potent and selective cytotoxic activity in KB and HepG2 cell lines, with IC<sub>50</sub> values ranging from 3.57 to 6.32 µM. The results also indicated that analogues with a 5-membered A-ring containing an <em>α</em>,<em>β</em>-unsaturated aldehyde esterified at C-23 showed a decrease in their cytotoxic activity compared to precursors in the tested cancer cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 868-873"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2425058
Pengyun Mou , Yuan Peng , Bangyan Zhang , Pengze Wang , Xianpu Ni , Huanzhang Xia
a new benzodioxole derivative 1,3-benzodioxole-2-one-4-N-methylcarboxylamide (1), two new natural products N-(aminocarbonyl)-2,3-dimethoxy-benzamide (2) and 2,3-dimethoxy-N-methylbenzamide (3), along with eight known compounds (4-11), were isolated from the marine-derived Streptomyces sp. SYPHU 0002. The structures of compounds 1-11 were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR. Compound 9 showed weak antibacterial activity against Bacillus pumilus with the MIC value of 64 μg mL−1.
{"title":"A new benzodioxole derivative from the marine-derived Streptomyces sp. SYPHU 0002","authors":"Pengyun Mou , Yuan Peng , Bangyan Zhang , Pengze Wang , Xianpu Ni , Huanzhang Xia","doi":"10.1080/14786419.2024.2425058","DOIUrl":"10.1080/14786419.2024.2425058","url":null,"abstract":"<div><div>a new benzodioxole derivative 1,3-benzodioxole-2-one-4-<em>N</em>-methylcarboxylamide (<strong>1</strong>), two new natural products <em>N</em>-(aminocarbonyl)-2,3-dimethoxy-benzamide (<strong>2</strong>) and 2,3-dimethoxy-<em>N</em>-methylbenzamide (<strong>3</strong>), along with eight known compounds (<strong>4</strong>-<strong>11</strong>), were isolated from the marine-derived <em>Streptomyces</em> sp. SYPHU 0002. The structures of compounds <strong>1</strong>-<strong>11</strong> were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR. Compound <strong>9</strong> showed weak antibacterial activity against <em>Bacillus pumilus</em> with the MIC value of 64 μg mL<sup>−1</sup>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 746-752"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2427806
Hilmican Caliskan , Temine Sabudak , H. Hulya Orak , Merve Argon , Cansel Cakir , Mehmet Ozturk
The genus Genista L. has been used in the treatment of rheumatic, diabetic and ulcerous diseases. Herein, the antioxidant, anticholinesterase, and antidiabetic activities of Genista carinalis Griseb. extracts were determined. The antioxidant activity was performed FRAP, DPPH, CUPRAC, and TEAC assays, while anticholinesterase activity was performed against acetylcholinesterase and butyrylcholinesterase, and antidiabetic activity against α-amylase and α-glucosidase, spectrophotometrically. The activity results allowed for the study of the phytochemistry of the ethyl acetate extract that exhibited the best activity. Three new isoflavonoids, 5-methyl-7-methoxy-4′-hydroxy isoflavone (3), 7-acetyl-5-hydroxy-4′-methoxy isoflavone (4) and 7-O-[β-D-glucopyranosyl-(6′′→6′′′)-β-D-glucopyranosyl]-5-4′-dihydroxy isoflavone (5), together with two known compounds, isoprunetin (1) and 6-hydroxy biochanin A (2) were isolated from the ethyl acetate extract. Their structures were elucidated by extensive 1D-, 2D-NMR, and MS data analyses. Compound (3) showed the highest antioxidant potential in TEAC, FRAP, and CUPRAC assays, while (2) exhibited higher butyrylcholinesterase enzyme inhibitory activity among the isolated compounds.
{"title":"Isolation of new isoflavonoids derivatives from Genista carinalis Griseb. and biological activity","authors":"Hilmican Caliskan , Temine Sabudak , H. Hulya Orak , Merve Argon , Cansel Cakir , Mehmet Ozturk","doi":"10.1080/14786419.2024.2427806","DOIUrl":"10.1080/14786419.2024.2427806","url":null,"abstract":"<div><div>The genus <em>Genista</em> L. has been used in the treatment of rheumatic, diabetic and ulcerous diseases. Herein, the antioxidant, anticholinesterase, and antidiabetic activities of <em>Genista carinalis</em> Griseb. extracts were determined. The antioxidant activity was performed FRAP, DPPH, CUPRAC, and TEAC assays, while anticholinesterase activity was performed against acetylcholinesterase and butyrylcholinesterase, and antidiabetic activity against α-amylase and α-glucosidase, spectrophotometrically. The activity results allowed for the study of the phytochemistry of the ethyl acetate extract that exhibited the best activity. Three new isoflavonoids, 5-methyl-7-methoxy-4′-hydroxy isoflavone <strong>(3)</strong>, 7-acetyl-5-hydroxy-4′-methoxy isoflavone <strong>(4)</strong> and 7-O-[β-D-glucopyranosyl-(6′′→6′′′)-β-D-glucopyranosyl]-5-4′-dihydroxy isoflavone <strong>(5)</strong>, together with two known compounds, isoprunetin <strong>(1)</strong> and 6-hydroxy biochanin A <strong>(2)</strong> were isolated from the ethyl acetate extract. Their structures were elucidated by extensive 1D-, 2D-NMR, and MS data analyses. Compound <strong>(3)</strong> showed the highest antioxidant potential in TEAC, FRAP, and CUPRAC assays, while <strong>(2)</strong> exhibited higher butyrylcholinesterase enzyme inhibitory activity among the isolated compounds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 860-867"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2025.2478529
Long-Fen Li , Ying-Ying Hu , Xin-Zhu Wang , Qing-Zhou Meng , Pei-Pei Zhao , Qiao-Ni Chen , Ying Xu , Xue-Kui Xia
A new aromatic diamide compound, aspergillusin A (1), together with three known compounds, globosterol (2), ergosterol (3), and cladosporide A (4), was isolated from the crude extract of the endophytic fungi Aspergillus sp. H30. The structures were elucidated using NMR and MS data, finally, the biosynthetic pathway of compound 1 was hypothesised. Compounds 1–4 were tested for their antibacterial activities on six pathogenic bacteria and compound 1 was also evaluated against human non-small cell lung cancer H1299. Among them, compound 1 exhibited weak antibacterial activity against MRSA and a strong effect against the human bronchial epithelial cell line, BEAS-2B, with an IC50 value of 12.32 ± 0.37 μM.
{"title":"Anti-MRSA and cytotoxic activity of a new diamide compound isolated from Aspergillus sp. H30","authors":"Long-Fen Li , Ying-Ying Hu , Xin-Zhu Wang , Qing-Zhou Meng , Pei-Pei Zhao , Qiao-Ni Chen , Ying Xu , Xue-Kui Xia","doi":"10.1080/14786419.2025.2478529","DOIUrl":"10.1080/14786419.2025.2478529","url":null,"abstract":"<div><div>A new aromatic diamide compound, aspergillusin A (<strong>1</strong>), together with three known compounds, globosterol (<strong>2</strong>), ergosterol (<strong>3</strong>), and cladosporide A (<strong>4</strong>), was isolated from the crude extract of the endophytic fungi <em>Aspergillus</em> sp. H30. The structures were elucidated using NMR and MS data, finally, the biosynthetic pathway of compound <strong>1</strong> was hypothesised. Compounds <strong>1</strong>–<strong>4</strong> were tested for their antibacterial activities on six pathogenic bacteria and compound <strong>1</strong> was also evaluated against human non-small cell lung cancer H1299. Among them, compound <strong>1</strong> exhibited weak antibacterial activity against MRSA and a strong effect against the human bronchial epithelial cell line, BEAS-2B, with an IC<sub>50</sub> value of 12.32 ± 0.37 <em>μ</em>M.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 924-930"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three new isochroman derivatives, penicitrisochromans A-C (1-3), together with 25 known polyketides were isolated from the marine-derived fungus Penicillium citrinum PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of 3 were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, ω-hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant Staphylococcus aureus with MIC values of 32, 16 and 4 µg/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against Candida albicans NCPF3153 and Cryptococcus neoformans ATCC90112 with the respective MIC values of 16 and 64 µg/mL.
从海洋源真菌柠檬青霉 PSU-MF100 中分离出了三种新的异色素衍生物--青霉色素 A-C （1-3），以及 25 种已知的多酮类化合物。通过大量光谱分析阐明了它们的结构。通过比旋和电子圆二色性（ECD）数据与已知共代谢物的比旋和电子圆二色性数据进行比较，确定了 1 和 2 的绝对构型，而 3 的绝对构型则是根据 ECD 计算和生物合成考虑确定的。在分离出的多酮类化合物中，ω-羟基大黄素、青霉蒽素 A 和大黄素这三种已知的蒽醌衍生物对耐甲氧西林金黄色葡萄球菌具有中等到较强的抗菌活性，其 MIC 值分别为 32、16 和 4 µg/mL。在抗真菌活性方面，两种已知的苯并吡喃酮类化合物，即 coniochaetones A 和 C，对白色念珠菌 NCPF3153 和新型隐球菌 ATCC90112 表现出中等程度的抗真菌活性，其 MIC 值分别为 16 和 64 微克/毫升。
{"title":"Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100","authors":"Panthong Thamsiri , Vatcharin Rukachaisirikul , Souwalak Phongpaichit , Sita Preedanon , Jariya Sakayaroj , Chatchai Muanprasat , Sarinya Hadsadee , Siriporn Jungsuttiwong","doi":"10.1080/14786419.2024.2416515","DOIUrl":"10.1080/14786419.2024.2416515","url":null,"abstract":"<div><div>Three new isochroman derivatives, penicitrisochromans A-C (<strong>1</strong>-<strong>3</strong>), together with 25 known polyketides were isolated from the marine-derived fungus <em>Penicillium citrinum</em> PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of <strong>1</strong> and <strong>2</strong> were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of <strong>3</strong> were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, <em>ω</em>-hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant <em>Staphylococcus aureus</em> with MIC values of 32, 16 and 4 <em>µ</em>g/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against <em>Candida albicans</em> NCPF3153 and <em>Cryptococcus neoformans</em> ATCC90112 with the respective MIC values of 16 and 64 <em>µ</em>g/mL.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 635-641"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study compared the triterpenoid ingredients, polysaccharide, protein, amino acid, and volatile components of PC. The PC was treated with traditional sweating (TST), steaming sweating for 1 to 4 h (SS1h-SS4h, Δ = 1 h) and non-sweating (NS). The results showed the content of six triterpenoids (1.03 mg/g), water-soluble protein (0.33 mg/g) and total triterpenoid (3.81 mg/g) were the highest in NS; the content of alkali-soluble polysaccharide (51.96 mg/g) was the highest in SS1h; the content of crude protein (16.18 mg/g) and total amino acid (53.07 mg/g) were highest in TST. Moreover, the predominant volatile component of SS1h was hexanal, SS2h-SS4h and TST were Linalool, NS was D-limonene. Ulteriorly, the correlation analysis showed antioxidant effect of PC may be related to the content of alkali-soluble polysaccharide, Furan-2-pentyl, and 2-Octenal, PCA result indicated the score of SS1h-treated PC was the highest. This study could provide a new solution for the industrial production of PC.
该研究比较了 PC 的三萜类成分、多糖、蛋白质、氨基酸和挥发性成分。PC 经传统发汗（TST）、蒸煮发汗 1 至 4 小时（SS1h-SS4h，Δ = 1 小时）和不发汗（NS）处理。结果表明，六种三萜类化合物（1.03 毫克/克）、水溶性蛋白质（0.33 毫克/克）和总三萜类化合物（3.81 毫克/克）的含量在 NS 中最高；碱溶性多糖（51.96 毫克/克）的含量在 SS1h 中最高；粗蛋白（16.18 毫克/克）和总氨基酸（53.07 毫克/克）的含量在 TST 中最高。此外，SS1h 的主要挥发性成分是己醛，SS2h-SS4h 和 TST 的主要挥发性成分是芳樟醇，NS 的主要挥发性成分是 D-柠檬烯。此外，相关分析表明 PC 的抗氧化效果可能与碱溶性多糖、呋喃-2-戊基和 2-辛烯醛的含量有关，PCA 结果表明 SS1h 处理的 PC 得分最高。这项研究可为 PC 的工业化生产提供新的解决方案。
{"title":"The effects of different processing treatments to active ingredients, nutrients, volatile components and antioxidant activity in Poria cocos wolf","authors":"Chuqian Gao , Miaofen Chen , Xiang Wei , Jianguo Zeng , Hongqi Xie","doi":"10.1080/14786419.2024.2421905","DOIUrl":"10.1080/14786419.2024.2421905","url":null,"abstract":"<div><div>The study compared the triterpenoid ingredients, polysaccharide, protein, amino acid, and volatile components of PC. The PC was treated with traditional sweating (TST), steaming sweating for 1 to 4 h (SS1h-SS4h, <em>Δ</em> = 1 h) and non-sweating (NS). The results showed the content of six triterpenoids (1.03 mg/g), water-soluble protein (0.33 mg/g) and total triterpenoid (3.81 mg/g) were the highest in NS; the content of alkali-soluble polysaccharide (51.96 mg/g) was the highest in SS1h; the content of crude protein (16.18 mg/g) and total amino acid (53.07 mg/g) were highest in TST. Moreover, the predominant volatile component of SS1h was hexanal, SS2h-SS4h and TST were Linalool, NS was D-limonene. Ulteriorly, the correlation analysis showed antioxidant effect of PC may be related to the content of alkali-soluble polysaccharide, Furan-2-pentyl, and 2-Octenal, PCA result indicated the score of SS1h-treated PC was the highest. This study could provide a new solution for the industrial production of PC.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 666-674"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The essential oils (EOs) of Cymbopogon schoenanthus (L.) Spreng. collected from Ghardaïa Province were analyzed for their chemical composition by GC-MS analysis. The results showed fifty-one identified compounds representing 94.34% of the whole EOs, with β-eudesmol (11.35%) and α-elemol (10.84%) as major compounds. The TAC, DPPH, and FRAP antioxidant activities of the EOs were moderate, while an important inhibition of 63.54 ± 2.41% was obtained for the β-carotene bleaching assay. The results of the antibacterial activity show that gentamicin had an inhibition zone of 21.66 ± 0.57 mm while Bacillus cereus was the most sensitive species (inhibition zone of 20.75 ± 0.50 mm). The wound-healing activity results showed contraction percentages on the 20th day of 99.35 ± 0.12%, which was similar to the positive control 1% allantoin (98.33 ± 0.17%). Our results show that C.schoenanthus is a source of many bioactive compounds with well-known antioxidant, antibacterial and wound-healing properties.
{"title":"Chemical composition and biological activities of essential oils from Cymbopogon schoenanthus (L.) Spreng.: a Saharan plant from Ghardaïa region (Algeria)","authors":"Hanane BenZetta , Faiza Baali , Nadjette Djemouai , Sofia Ayari-Guentri , Somia Saad , Kathia Belaid , Elyes Kelai","doi":"10.1080/14786419.2024.2425811","DOIUrl":"10.1080/14786419.2024.2425811","url":null,"abstract":"<div><div>The essential oils (EOs) of <em>Cymbopogon schoenanthus</em> (L.) Spreng. collected from Ghardaïa Province were analyzed for their chemical composition by GC-MS analysis. The results showed fifty-one identified compounds representing 94.34% of the whole EOs, with β-eudesmol (11.35%) and α-elemol (10.84%) as major compounds. The TAC, DPPH, and FRAP antioxidant activities of the EOs were moderate, while an important inhibition of 63.54 ± 2.41% was obtained for the β-carotene bleaching assay. The results of the antibacterial activity show that gentamicin had an inhibition zone of 21.66 ± 0.57 mm while <em>Bacillus cereus</em> was the most sensitive species (inhibition zone of 20.75 ± 0.50 mm). The wound-healing activity results showed contraction percentages on the 20<sup>th</sup> day of 99.35 ± 0.12%, which was similar to the positive control 1% allantoin (98.33 ± 0.17%). Our results show that <em>C.</em> <em>schoenanthus</em> is a source of many bioactive compounds with well-known antioxidant, antibacterial and wound-healing properties.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 791-803"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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