Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2289085
Yuanyuan Lu , Qianqian Xu , Liangfang Pang , Yarui Liu , Liangxia Li , Jiayan Yan , Yonghui Zhang , Ziming Huang
Two new fungal polyketides with unusual skeleton, collecapsins A and B (1–2), along with two known macrolactins A and B (3–4), were isolated from the rice cultures of an endophytic fungus Colletotrichum capsici obtained from the fresh Siegesbeckia pubescens Makino. Their structures were established by a combination of NMR, HRESIMS, and IR analysis. The absolute configurations of 1 and 2 were determined on the detailed analysis of the modified Mosher’s derivatives’ spectra and its key NOEs correlations. In this case, the absolute configurations of all chiral centres of 1 were determined for the first time, showed that 1 is a C-6/C-8 epimer of colletruncoic acid methyl ester. Compounds 1–2 demonstrated promising lipid lowing activity via the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with IC50 values of 8.72 and 15.28 μM. Compounds 3–4 exhibited antibacterial activity with MIC values ranging from 0.25–25.8 μM.
{"title":"HMG-CoA reductase inhibitor from the endophytic fungus Colletotrichum Capsici","authors":"Yuanyuan Lu , Qianqian Xu , Liangfang Pang , Yarui Liu , Liangxia Li , Jiayan Yan , Yonghui Zhang , Ziming Huang","doi":"10.1080/14786419.2023.2289085","DOIUrl":"10.1080/14786419.2023.2289085","url":null,"abstract":"<div><div>Two new fungal polyketides with unusual skeleton, collecapsins A and B (<strong>1</strong>–<strong>2</strong>), along with two known macrolactins A and B (<strong>3</strong>–<strong>4</strong>), were isolated from the rice cultures of an endophytic fungus <em>Colletotrichum capsici</em> obtained from the fresh <em>Siegesbeckia pubescens</em> Makino. Their structures were established by a combination of NMR, HRESIMS, and IR analysis. The absolute configurations of <strong>1</strong> and <strong>2</strong> were determined on the detailed analysis of the modified Mosher’s derivatives’ spectra and its key NOEs correlations. In this case, the absolute configurations of all chiral centres of <strong>1</strong> were determined for the first time, showed that <strong>1</strong> is a C-6/C-8 epimer of colletruncoic acid methyl ester. Compounds <strong>1</strong>–<strong>2</strong> demonstrated promising lipid lowing activity <em>via</em> the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with IC<sub>50</sub> values of 8.72 and 15.28 μM. Compounds <strong>3</strong>–<strong>4</strong> exhibited antibacterial activity with MIC values ranging from 0.25–25.8 μM.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 749-757"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138715111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2319660
Aishna Chauhan , Ritesh Banerjee
The Pyracantha genus consists of evergreen shrubs distributed from Southeast Europe to South-East Asia. They are found in geographical regions of India, China, and South West Europe. They are used in traditional medicines against earache, menstrual cycles, constipation etc. The genus is pharmacologically significant because of its antioxidant and antimicrobial effects. The genus also acts as a biomonitor species for heavy metals and bio sorbent in wastewater treatment. The review aims to present an overview of four species of the Pyracantha genus -P. crenulata, P. fortuneana, and P. coccinea and P. angustifolia. The comparison of their geographical distribution, traditional uses, therapeutic uses, phytochemical components and future prospects has been described. In this study, 189 research and review articles were scanned to provide summarised research of phytochemical composition, pharmacological effects and future prospects of the species which can benefit the plant as a therapeutic drug or as a functional food.
{"title":"Evaluation of traditional uses, phytochemical constituents, therapeutic uses and future prospects of Pyracantha genus: a systematic review","authors":"Aishna Chauhan , Ritesh Banerjee","doi":"10.1080/14786419.2024.2319660","DOIUrl":"10.1080/14786419.2024.2319660","url":null,"abstract":"<div><div>The Pyracantha genus consists of evergreen shrubs distributed from Southeast Europe to South-East Asia. They are found in geographical regions of India, China, and South West Europe. They are used in traditional medicines against earache, menstrual cycles, constipation etc. The genus is pharmacologically significant because of its antioxidant and antimicrobial effects. The genus also acts as a biomonitor species for heavy metals and bio sorbent in wastewater treatment. The review aims to present an overview of four species of the Pyracantha genus -<em>P. crenulata, P. fortuneana, and P. coccinea</em> and <em>P. angustifolia</em>. The comparison of their geographical distribution, traditional uses, therapeutic uses, phytochemical components and future prospects has been described. In this study, 189 research and review articles were scanned to provide summarised research of phytochemical composition, pharmacological effects and future prospects of the species which can benefit the plant as a therapeutic drug or as a functional food.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 922-934"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2287183
Ana Maria Henrique Moniz , Francisco Humberto Xavier Junior , Giovanna Melo Martins Silva , Ana Cristina Gonçalves Reis de Melo , Maylla Maria Correia Leite Silva , Weslley Souza Paiva , Hugo Alexandre Oliveira Rocha , Luiz Antônio Mendonça Alves da Costa , Antônio Alves de Melo Filho , Riva de Paula Oliveira
Lippia origanoides essential oil (LOEO) is extensively utilised as food preservative due to its antioxidant and antibacterial activities. In this study, the antioxidant and anti-ageing effects of LOEO was investigated in vivo using the nematode Caenorhabditis elegans. The gas chromatography-mass spectrometry analysis indicated that the main components of LOEO are carvacrol and thymol. LOEO treatment improved physiological parameters such as pharyngeal pumping, locomotion and body size indicating that is not toxic to C. elegans. LOEO treatment showed antioxidant effect in C. elegans by reducing endogenous ROS (Reactive Oxygen Species) production and increasing their survival under oxidative stress. Finally, LOEO treatment significantly extended C. elegans lifespan and alleviated the paralysis induced by β-amyloid peptide overexpression in the muscle. This work demonstrates for the first time LOEO antioxidant and anti-ageing properties on an organism level providing a valuable proof of principle to support further studies in the development of nutraceuticals or antioxidant phytotherapy.
{"title":"Lippia origanoides essential oil increases longevity and ameliorates β-amyloid peptide-induced toxicity in Caenorhabditis elegans","authors":"Ana Maria Henrique Moniz , Francisco Humberto Xavier Junior , Giovanna Melo Martins Silva , Ana Cristina Gonçalves Reis de Melo , Maylla Maria Correia Leite Silva , Weslley Souza Paiva , Hugo Alexandre Oliveira Rocha , Luiz Antônio Mendonça Alves da Costa , Antônio Alves de Melo Filho , Riva de Paula Oliveira","doi":"10.1080/14786419.2023.2287183","DOIUrl":"10.1080/14786419.2023.2287183","url":null,"abstract":"<div><div><em>Lippia origanoides</em> essential oil (LOEO) is extensively utilised as food preservative due to its antioxidant and antibacterial activities. In this study, the antioxidant and anti-ageing effects of LOEO was investigated <em>in vivo</em> using the nematode <em>Caenorhabditis elegans</em>. The gas chromatography-mass spectrometry analysis indicated that the main components of LOEO are carvacrol and thymol. LOEO treatment improved physiological parameters such as pharyngeal pumping, locomotion and body size indicating that is not toxic to <em>C. elegans</em>. LOEO treatment showed antioxidant effect in <em>C. elegans</em> by reducing endogenous ROS (Reactive Oxygen Species) production and increasing their survival under oxidative stress. Finally, LOEO treatment significantly extended <em>C. elegans</em> lifespan and alleviated the paralysis induced by β-amyloid peptide overexpression in the muscle. This work demonstrates for the first time LOEO antioxidant and anti-ageing properties on an organism level providing a valuable proof of principle to support further studies in the development of nutraceuticals or antioxidant phytotherapy.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 695-703"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2288227
Xiaoxuan Liu , Jianqiong Yang , Yang Yang , Yifang Yang , Xingdong Kang , Yang Ye , Xiaofeng Li , Yongzhong Wu , Junping Xiao , Li Li , Hongyang Zhang , Bin Zhou , Hai Liu
Callicarpa nudiflora (C. nudiflora) is widely used in the treatment of bleeding related diseases. However, its main material basis has not been fully defined which limits the in-depth study of screening out the material basis of hemostasis and coagulation from C. nudiflor. In this study, the method of spectrum-effect relationship was used to quickly screen the material basis of hemostasis and coagulation. The five compounds related to hemostasis and coagulation were screened as Alyssonoside (P24), Luteolin (P25), Quercetin (P26), Apigenin (P28), Isorhamnetin (P29). And the contribution of these five peaks to hemostasis and coagulation efficacy was P24 > P25 > P28 > P26 > P29.
{"title":"Research on the hemostasis and coagulation effects of Callicarpa nudiflora based on the spectrum-effect relationship","authors":"Xiaoxuan Liu , Jianqiong Yang , Yang Yang , Yifang Yang , Xingdong Kang , Yang Ye , Xiaofeng Li , Yongzhong Wu , Junping Xiao , Li Li , Hongyang Zhang , Bin Zhou , Hai Liu","doi":"10.1080/14786419.2023.2288227","DOIUrl":"10.1080/14786419.2023.2288227","url":null,"abstract":"<div><div><em>Callicarpa nudiflora</em> (<em>C. nudiflora)</em> is widely used in the treatment of bleeding related diseases. However, its main material basis has not been fully defined which limits the in-depth study of screening out the material basis of hemostasis and coagulation from <em>C. nudiflor</em>. In this study, the method of spectrum-effect relationship was used to quickly screen the material basis of hemostasis and coagulation. The five compounds related to hemostasis and coagulation were screened as Alyssonoside (P24), Luteolin (P25), Quercetin (P26), Apigenin (P28), Isorhamnetin (P29). And the contribution of these five peaks to hemostasis and coagulation efficacy was P24 > P25 > P28 > P26 > P29.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 704-711"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2290147
Sherif A. Hamdy , Mona M. Hashem , Hala M. El Hefnawy , Shadia M. Azzam , El-Sayed A. Aboutabl
Metabolomics study of Hydrocotyle umbellata L. revealed the richness of its aerial parts in phenolics primarily; quercetin and its glycoside derivatives, which are well-reported to exert antidiabetic activity owing to their powerful antioxidant capacity. Hence, the antioxidant and antidiabetic potentials of the quercetin standardized ethanolic extract of H. umbellata aerial parts were investigated. The antioxidant activity was examined by using in-vitro 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, while the antidiabetic activity was examined by using in-vitroα-glucosidase inhibitory assay and further confirmed by in-vivo experiments using streptozotocin-induced diabetes in rat model. Interestingly, the standardized ethanolic extract showed significant in-vitro antioxidant activity, and effectively inhibited Saccharomyces cerevisiae α-glucosidase enzyme activity. Moreover, it significantly reduced fasting blood glucose, triglycerides, and cholesterol levels. Thus, H. umbellata is a potential natural candidate to attenuate diabetes mellitus and its altered lipid profile complications, which could be attributed to its quercetin and quercetin glycosides content.
{"title":"Hydrocotyle umbellata L.; a natural source of bioactives to mitigate diabetes mellitus and its complications","authors":"Sherif A. Hamdy , Mona M. Hashem , Hala M. El Hefnawy , Shadia M. Azzam , El-Sayed A. Aboutabl","doi":"10.1080/14786419.2023.2290147","DOIUrl":"10.1080/14786419.2023.2290147","url":null,"abstract":"<div><div>Metabolomics study of <em>Hydrocotyle umbellata</em> L. revealed the richness of its aerial parts in phenolics primarily; quercetin and its glycoside derivatives, which are well-reported to exert antidiabetic activity owing to their powerful antioxidant capacity. Hence, the antioxidant and antidiabetic potentials of the quercetin standardized ethanolic extract of <em>H. umbellata</em> aerial parts were investigated. The antioxidant activity was examined by using <em>in-vitro</em> 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, while the antidiabetic activity was examined by using <em>in-vitro</em> <em>α-</em>glucosidase inhibitory assay and further confirmed by <em>in-vivo</em> experiments using streptozotocin-induced diabetes in rat model. Interestingly, the standardized ethanolic extract showed significant <em>in-vitro</em> antioxidant activity, and effectively inhibited <em>Saccharomyces cerevisiae α-</em>glucosidase enzyme activity. Moreover, it significantly reduced fasting blood glucose, triglycerides, and cholesterol levels. Thus, <em>H. umbellata</em> is a potential natural candidate to attenuate diabetes mellitus and its altered lipid profile complications, which could be attributed to its quercetin and quercetin glycosides content.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 1015-1018"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2316328
Merehan Alaa-ElDin. Mohamed , Shaimaa Rihan , Mustafa M.M. Elbakry , Said S. Moselhy
Autophagy is a very well-conserved self-digestive mechanism that transports unwanted or disposable cytoplasmic debris to lysosomes for destruction, including misfolded proteins and damaged organelles. Advanced liver illnesses can develop from the prevalent clinical condition known as non-alcoholic steatohepatitis (NASH). There is no effective treatment, is still unclear. Therefore, in order to create novel therapeutics, it is necessary to comprehend the pathogenic pathways causing disease onset and progression. Natural components from medicinal plants are currently the subject of a larger number of studies since they provide fresh promise for NASH. This review provided an overview of the aetiology of NASH, in addition the role of natural products as alternative or complementary therapeutic agent for management of NASH via autophagy induction. It was concluded that, alternative and complementary supplement of natural functional food as Arabica coffee that rich with chlorogenic acid targeting autophagy mechanism mediate amelioration effect of NASH.
{"title":"Molecular docking targeting autophagy pathway mediate abrogation of NASH by specific functional foods: update review","authors":"Merehan Alaa-ElDin. Mohamed , Shaimaa Rihan , Mustafa M.M. Elbakry , Said S. Moselhy","doi":"10.1080/14786419.2024.2316328","DOIUrl":"10.1080/14786419.2024.2316328","url":null,"abstract":"<div><div>Autophagy is a very well-conserved self-digestive mechanism that transports unwanted or disposable cytoplasmic debris to lysosomes for destruction, including misfolded proteins and damaged organelles. Advanced liver illnesses can develop from the prevalent clinical condition known as non-alcoholic steatohepatitis (NASH). There is no effective treatment, is still unclear. Therefore, in order to create novel therapeutics, it is necessary to comprehend the pathogenic pathways causing disease onset and progression. Natural components from medicinal plants are currently the subject of a larger number of studies since they provide fresh promise for NASH. This review provided an overview of the aetiology of NASH, in addition the role of natural products as alternative or complementary therapeutic agent for management of NASH <em>via</em> autophagy induction. It was concluded that, alternative and complementary supplement of natural functional food as Arabica coffee that rich with chlorogenic acid targeting autophagy mechanism mediate amelioration effect of NASH.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 864-887"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2281003
Bich Ngan Truong , Thi Mai Huong Doan , Thuy Linh Nguyen , Van Nam Vu , Van Hieu Tran , Marc Litaudon , Van Cuong Pham
Two new flavonoids, 4′,5,7-trihydroxy-5′-methoxy-6,8-dimethylisoflavone (1) and 2′,5′,7-trihydroxy-5-methoxy-6,8-dimethylflavanone (2) together with the known flavonoids 4´,5,7-trihydroxy-3´-methoxy-6.8-dimethylflavone (3), epigallocatechin (4), 4´-O-methylepicatechin (5) and quercetin (6) were isolated from the roots of Byttneria aspera. The structures of these compounds were determined by means of spectroscopic methods. Compounds 1–6 were submitted to cytotoxic activity assays against three cancer cell lines including KB, MCF7 and A549, as well as their antimicrobial activity against a panel of clinically significant microorganisms. Compound 6 showed moderate cytotoxic activity with IC50 values of 12.7, 56.9 and 17.5 µM against KB, MCF7 and A549. Interestingly, the new compounds 1 and 2 exhibits antimicrobial activity, with compound 1 displaying selective antifungal activity against Candida albicans giving an MIC value of 128 µg/mL, compared to cyclohexamide with 32 µg/mL, while compound 2 shows potent inhibition of the Gram-positive bacterium Enterococcus faecalis displaying an MIC of 64 µg/mL, compared to streptomycin with 256 µg/mL.
从白楝根中分离得到2个新的黄酮类化合物4′，5,7-三羟基-5′-甲氧基-6,8-二甲基异黄酮(1)和2′，5′，7-三羟基-5′-甲氧基-6,8-二甲基黄酮(2)，以及已知的黄酮类化合物4′，5,7-三羟基-3′-甲氧基-6.8-二甲基黄酮(3)、表没食子儿茶素(4)、4′- o -甲基儿茶素(5)和槲皮素(6)。这些化合物的结构用光谱学方法进行了测定。化合物1-6对三种癌细胞(KB、MCF7和A549)进行了细胞毒活性测定，并对一组临床重要微生物进行了抑菌活性测定。化合物6对KB、MCF7和A549的IC50值分别为12.7、56.9和17.5µM，具有中等的细胞毒活性。有趣的是，新化合物1和2表现出抗菌活性，化合物1对白色念珠菌具有选择性抗真菌活性，MIC值为128µg/mL，而环六甲胺为32µg/mL，而化合物2对革兰氏阳性细菌粪肠球菌具有有效抑制作用，MIC值为64µg/mL，而链霉素为256µg/mL。
{"title":"Two new flavonoids with antimicrobial activity from the roots of Byttneria aspera Colebr. ex Wall (Malvaceae)","authors":"Bich Ngan Truong , Thi Mai Huong Doan , Thuy Linh Nguyen , Van Nam Vu , Van Hieu Tran , Marc Litaudon , Van Cuong Pham","doi":"10.1080/14786419.2023.2281003","DOIUrl":"10.1080/14786419.2023.2281003","url":null,"abstract":"<div><div>Two new flavonoids, 4′,5,7-trihydroxy-5′-methoxy-6,8-dimethylisoflavone (<strong>1</strong>) and 2′,5′,7-trihydroxy-5-methoxy-6,8-dimethylflavanone (<strong>2</strong>) together with the known flavonoids 4´,5,7-trihydroxy-3´-methoxy-6.8-dimethylflavone (<strong>3</strong>), epigallocatechin (<strong>4</strong>), 4´-O-methylepicatechin (<strong>5</strong>) and quercetin (<strong>6</strong>) were isolated from the roots of <em>Byttneria aspera</em>. The structures of these compounds were determined by means of spectroscopic methods. Compounds <strong>1</strong>–<strong>6</strong> were submitted to cytotoxic activity assays against three cancer cell lines including KB, MCF7 and A549, as well as their antimicrobial activity against a panel of clinically significant microorganisms. Compound <strong>6</strong> showed moderate cytotoxic activity with IC<sub>50</sub> values of 12.7, 56.9 and 17.5 µM against KB, MCF7 and A549. Interestingly, the new compounds <strong>1</strong> and <strong>2</strong> exhibits antimicrobial activity, with compound <strong>1</strong> displaying selective antifungal activity against <em>Candida albicans</em> giving an MIC value of 128 µg/mL, compared to cyclohexamide with 32 µg/mL, while compound <strong>2</strong> shows potent inhibition of the Gram-positive bacterium <em>Enterococcus faecalis</em> displaying an MIC of 64 µg/mL, compared to streptomycin with 256 µg/mL.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 976-980"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2287170
Maria Pierdomenico , Loretta Bacchetta , Barbara Benassi
An ethanolic extract of Corylus avellana L. hazelnut was characterised by liquid chromatography coupled to high resolution mass spectrometry. We here evaluated the in vitro cytotoxic response to such extract in HepG2 cells and tried to depict the underlying mechanism(s) in terms of microRNA-34b/c involvement. Following long-term exposure (144h) of HepG2 cells with 0.04-0.4 mg/ml of hazelnut extract, we demonstrated that miR-34 precursor RNA and both mature miR-34b and miR-34c molecules underwent a significant stimulation (>2-fold change, p < 0.05) in cells treated with the highest concentration. The epigenetic modulation was accompanied by the inhibition of cell proliferation, the decrease of viability and activation of apoptosis at 144h of treatment with 0.4 mg/ml of hazelnut.These in vitro findings demonstrate the cytotoxic effect of the C. avellana extract in HepG2 cells and open the way to in vivo validation of possible application of hazelnut-based extracts, and/or its metabolites, as promising epigenetics drugs.
{"title":"The ethanolic extract of Corylus avellana L. drives a microRNA-based cytotoxic effect on HepG2 hepatocarcinoma cells","authors":"Maria Pierdomenico , Loretta Bacchetta , Barbara Benassi","doi":"10.1080/14786419.2023.2287170","DOIUrl":"10.1080/14786419.2023.2287170","url":null,"abstract":"<div><div>An ethanolic extract of <em>Corylus avellana L.</em> hazelnut was characterised by liquid chromatography coupled to high resolution mass spectrometry. We here evaluated the <em>in vitro</em> cytotoxic response to such extract in HepG2 cells and tried to depict the underlying mechanism(s) in terms of microRNA-34b/c involvement. Following long-term exposure (144h) of HepG2 cells with 0.04-0.4 mg/ml of hazelnut extract, we demonstrated that miR-34 precursor RNA and both mature miR-34b and miR-34c molecules underwent a significant stimulation (>2-fold change, <em>p</em> < 0.05) in cells treated with the highest concentration. The epigenetic modulation was accompanied by the inhibition of cell proliferation, the decrease of viability and activation of apoptosis at 144h of treatment with 0.4 mg/ml of hazelnut.These <em>in vitro</em> findings demonstrate the cytotoxic effect of the <em>C. avellana</em> extract in HepG2 cells and open the way to <em>in vivo</em> validation of possible application of hazelnut-based extracts, and/or its metabolites, as promising epigenetics drugs.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 674-681"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2315594
Soching Luikham , Jhimli Bhattacharyya
An ethnobotanical documentation on the medicinal plants used by local people of Nagaland (North-east India) has been presented here. The study explored 33 plant species (with their local names, indigenous applications, sources/origins, parts of plants used, bioactive compounds present, process of preparing medicines from the plants) belonging to 28 families have been reviewed thoroughly. Some examples are, Catharanthus roseus (Tsuinrinaro, Periwinkle), Acacia pennata (Chakrangaing, Ballikhadira), Adhatoda vasica (Kicharangnaro, Malabar-nut), Ageratum conzyoides (Imchenriza, Billy-goat-weed,/Tropical-white-weed), Alstonia scholaris (Lazarongpang, Blackboard), Rauvolfia serpentina (Per-mozutong, Indian-snakeroot), etc. Plant based drugs are very popular and effective in Nagaland from ancient times but thorough-documentation with scientific-background of effectiveness, active chemical-compounds present, their action-mechanism, etc., are still scanty. Such review can be of useful for pharmacologist, phyto-chemists to a broad group of researchers and may lead to discovery of new sources of novel medicines through traditional therapeutic knowledge.
{"title":"On the traditional medicinal plants and plant-derived natural drugs used by indigenous people of Nagaland, India","authors":"Soching Luikham , Jhimli Bhattacharyya","doi":"10.1080/14786419.2024.2315594","DOIUrl":"10.1080/14786419.2024.2315594","url":null,"abstract":"<div><div>An ethnobotanical documentation on the medicinal plants used by local people of Nagaland (North-east India) has been presented here. The study explored 33 plant species (with their local names, indigenous applications, sources/origins, parts of plants used, bioactive compounds present, process of preparing medicines from the plants) belonging to 28 families have been reviewed thoroughly. Some examples are, <em>Catharanthus roseus</em> (<em>Tsuinrinaro</em>, Periwinkle), <em>Acacia pennata</em> (<em>Chakrangaing</em>, Ballikhadira), <em>Adhatoda vasica</em> (<em>Kicharangnaro,</em> Malabar-nut), <em>Ageratum conzyoides</em> (<em>Imchenriza</em>, Billy-goat-weed,/Tropical-white-weed), <em>Alstonia scholaris</em> (<em>Lazarongpang</em>, Blackboard), <em>Rauvolfia serpentina</em> (<em>Per-mozutong</em>, Indian-snakeroot), etc. Plant based drugs are very popular and effective in Nagaland from ancient times but thorough-documentation with scientific-background of effectiveness, active chemical-compounds present, their action-mechanism, etc., are still scanty. Such review can be of useful for pharmacologist, phyto-chemists to a broad group of researchers and may lead to discovery of new sources of novel medicines through traditional therapeutic knowledge.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 848-863"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2283760
Elsevar Babaoglu Farzaliev , Salih Ökten
In this study, we developed a technology for the production of jelly confiture based on natural hawthorn puree. The use of activated low-esterified hawthorn pectin in the recipe was shown to increase the complexing ability of the product in relation to zinc and lead ions, making it suitable for functional preventive nutrition. The final product was characterised by a bright orange-yellow colour, a distinct hawthorn taste and odour, and a gelatinous consistency. Evaluation of the product based on organoleptic, physicochemical, and microbiological indicators showed that it had high nutritional and physiological value due to its retention of native micronutrients, high content of potassium, magnesium, and calcium, and antioxidant activity. The use of this product in a daily diet can satisfy the daily need for physiologically active substances and food ingredients. Overall, the use of natural puree from wild hawthorn fruit in the technology of jelly confiture allows for the expansion of raw material sources in the production of confectionery products with high nutritional and physiological value.
{"title":"Production and characterization of fruit jam with activated pectin using wild hawthorn puree (Crataegus monogyna Jacq.)","authors":"Elsevar Babaoglu Farzaliev , Salih Ökten","doi":"10.1080/14786419.2023.2283760","DOIUrl":"10.1080/14786419.2023.2283760","url":null,"abstract":"<div><div>In this study, we developed a technology for the production of jelly confiture based on natural hawthorn puree. The use of activated low-esterified hawthorn pectin in the recipe was shown to increase the complexing ability of the product in relation to zinc and lead ions, making it suitable for functional preventive nutrition. The final product was characterised by a bright orange-yellow colour, a distinct hawthorn taste and odour, and a gelatinous consistency. Evaluation of the product based on organoleptic, physicochemical, and microbiological indicators showed that it had high nutritional and physiological value due to its retention of native micronutrients, high content of potassium, magnesium, and calcium, and antioxidant activity. The use of this product in a daily diet can satisfy the daily need for physiologically active substances and food ingredients. Overall, the use of natural puree from wild hawthorn fruit in the technology of jelly confiture allows for the expansion of raw material sources in the production of confectionery products with high nutritional and physiological value.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 993-997"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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