Pub Date : 2024-09-27DOI: 10.1080/14786419.2024.2408400
Vanitha Marunganathan, Ajay Guru
{"title":"Fungal endophytes in action: a green approach to soil detoxification and restoration.","authors":"Vanitha Marunganathan, Ajay Guru","doi":"10.1080/14786419.2024.2408400","DOIUrl":"https://doi.org/10.1080/14786419.2024.2408400","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-27DOI: 10.1080/14786419.2024.2406993
Reena V Mathai, Santosh Kumar Sar, Jayati Chatterjee Mitra, Manoj Kumar Jindal, Faming Wang
Bioactive components used to treat human ailments are abundant in medicinal plants. Mentha arvensis and Aegle marmelos have therapeutic properties due to the presence of many phytonutrients. Gas chromatography-mass spectrometry (GC-MS) was used to evaluate the properties of the antioxidant and anticancer bioactive components found in the ethanolic extracts of Mentha arvensis and Aegle marmelos leaves. The major constituents identified in the leaf extracts were octadecanoic acid, heptadecanoic acid, 15-methyl-9,12,15-octadecatrienoic acid, ethyl ester, hexadecanoic acid, neophytadiene, pentadecane, hexadecane, and 1-octadecanol. Some of these components have antibacterial, antioxidant, anticancer, and anti-inflammatory properties. Among the identified compounds, octadecanoic acid and n-hexadecanoic acid are pivotal for their anticancer and antioxidant effects. The GC-MS characterisation indicated the existence of abundant bioactive compounds, confirming their potential therapeutic activities. This study showed that the leaves of Mentha arvensis and Aegle marmelos could be used as novel sources of antioxidants and anticancer medicines.
{"title":"Ethanolic extraction and GC-MS analysis of antioxidant and anticancer bioactive compounds from <i>Mentha arvensis</i> and <i>Aegle marmelos</i>.","authors":"Reena V Mathai, Santosh Kumar Sar, Jayati Chatterjee Mitra, Manoj Kumar Jindal, Faming Wang","doi":"10.1080/14786419.2024.2406993","DOIUrl":"https://doi.org/10.1080/14786419.2024.2406993","url":null,"abstract":"<p><p>Bioactive components used to treat human ailments are abundant in medicinal plants. <i>Mentha arvensis</i> and <i>Aegle marmelos</i> have therapeutic properties due to the presence of many phytonutrients. Gas chromatography-mass spectrometry (GC-MS) was used to evaluate the properties of the antioxidant and anticancer bioactive components found in the ethanolic extracts of <i>Mentha arvensis</i> and <i>Aegle marmelos</i> leaves. The major constituents identified in the leaf extracts were octadecanoic acid, heptadecanoic acid, 15-methyl-9,12,15-octadecatrienoic acid, ethyl ester, hexadecanoic acid, neophytadiene, pentadecane, hexadecane, and 1-octadecanol. Some of these components have antibacterial, antioxidant, anticancer, and anti-inflammatory properties. Among the identified compounds, octadecanoic acid and n-hexadecanoic acid are pivotal for their anticancer and antioxidant effects. The GC-MS characterisation indicated the existence of abundant bioactive compounds, confirming their potential therapeutic activities. This study showed that the leaves of <i>Mentha arvensis</i> and <i>Aegle marmelos</i> could be used as novel sources of antioxidants and anticancer medicines.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-26DOI: 10.1080/14786419.2024.2408656
Deepavalli Arumuganainar, Saravanan Sekaran
{"title":"Exploring the therapeutic role of Solasodine in oral cancer management.","authors":"Deepavalli Arumuganainar, Saravanan Sekaran","doi":"10.1080/14786419.2024.2408656","DOIUrl":"https://doi.org/10.1080/14786419.2024.2408656","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-26DOI: 10.1080/14786419.2024.2408412
Hethesh Chellapandian, Sivakamavalli Jeyachandran
Conotoxins, peptides derived from the venom of marine cone snails, have emerged as promising analgesics for managing pain associated with neck and spinal surgery. These toxins target specific neurotransmitter receptors and ion channels in the nervous system, offering an alternative to traditional opioids with potentially fewer side effects. By interacting with receptors such as nicotinic acetylcholine and voltage-gated sodium and calcium channels, conotoxins disrupt pain signal transmission and induce muscle relaxation, providing effective pain relief. Research into conotoxins is ongoing, with the goal of developing novel, safer analgesics that mitigate the risks of opioid addiction. This exploration not only holds promise for surgical pain management but also advances our understanding of venom pharmacology and its therapeutic applications.
{"title":"Conotoxins: emerging analgesics for neck and spinal surgery pain management.","authors":"Hethesh Chellapandian, Sivakamavalli Jeyachandran","doi":"10.1080/14786419.2024.2408412","DOIUrl":"https://doi.org/10.1080/14786419.2024.2408412","url":null,"abstract":"<p><p>Conotoxins, peptides derived from the venom of marine cone snails, have emerged as promising analgesics for managing pain associated with neck and spinal surgery. These toxins target specific neurotransmitter receptors and ion channels in the nervous system, offering an alternative to traditional opioids with potentially fewer side effects. By interacting with receptors such as nicotinic acetylcholine and voltage-gated sodium and calcium channels, conotoxins disrupt pain signal transmission and induce muscle relaxation, providing effective pain relief. Research into conotoxins is ongoing, with the goal of developing novel, safer analgesics that mitigate the risks of opioid addiction. This exploration not only holds promise for surgical pain management but also advances our understanding of venom pharmacology and its therapeutic applications.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-26DOI: 10.1080/14786419.2024.2408657
Jie Mu, Rui-Dong Wang, Yi-Shu Zhao, Tian-Chi Lu, Si-Si Chen, Yi-Jing Wang, Hua Wei, Li-Wei Zou
Pancreatic lipase (PL) is the main enzyme in the digestive system that breaks down triglyceride and promotes its absorption. In this paper, we found that lignans 2, 3 and 21, curcuminoids 24-26 exhibited significant inhibitory potential against PL. The structure-activity relationship (SAR) indicated that benzo-1, 3-dioxole group in the construction of lignans is essential to inhibitory effects against PL, while double bonds at C-7/C-2 position and 4-hydroxyphenyl moiety in the structure of curcuminoids are beneficial for PL inhibition. The kinetic studies and molecular docking were also conducted, the results showed that the three curcuminoids with the strongest inhibition effect above were all mixed inhibitors of PL. Furthermore, curcuminoids 24-26 displayed a preferential selectivity towards, in contrast to other serine hydrolases. The above results indicate that lignans and curcuminoids are natural functional components for PL inhibition, providing new ideas for finding and developing novel lead compounds for the treatment of obesity.
{"title":"Discovery of lignans and curcuminoids as the effective inhibitors of pancreatic lipase: structure-activity relationship and inhibitory mechanism.","authors":"Jie Mu, Rui-Dong Wang, Yi-Shu Zhao, Tian-Chi Lu, Si-Si Chen, Yi-Jing Wang, Hua Wei, Li-Wei Zou","doi":"10.1080/14786419.2024.2408657","DOIUrl":"https://doi.org/10.1080/14786419.2024.2408657","url":null,"abstract":"<p><p>Pancreatic lipase (PL) is the main enzyme in the digestive system that breaks down triglyceride and promotes its absorption. In this paper, we found that lignans <b>2</b>, <b>3</b> and <b>21</b>, curcuminoids <b>24-26</b> exhibited significant inhibitory potential against PL. The structure-activity relationship (SAR) indicated that benzo-1, 3-dioxole group in the construction of lignans is essential to inhibitory effects against PL, while double bonds at C-7/C-2 position and 4-hydroxyphenyl moiety in the structure of curcuminoids are beneficial for PL inhibition. The kinetic studies and molecular docking were also conducted, the results showed that the three curcuminoids with the strongest inhibition effect above were all mixed inhibitors of PL. Furthermore, curcuminoids <b>24-26</b> displayed a preferential selectivity towards, in contrast to other serine hydrolases. The above results indicate that lignans and curcuminoids are natural functional components for PL inhibition, providing new ideas for finding and developing novel lead compounds for the treatment of obesity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present research, ten species of Asparagus from North India have been analysed for secondary metabolites. The quantitative study of shatavarin IV, sarsasapogenin, caffeic acid, β-sitosterol, and lupeol in the cladodes and roots of Asparagus was conducted using a validated HPTLC method. The content of sarsasapogenin was found highest in the cladodes of A. racemosus (11.20 ± 0.025 mg/g DW) and roots of A. officinalis (5.95 ± 0.024 mg/g DW). Shatavarin IV was found highest in cladodes of A. densiflorus (6.72 ± 0.02 mg/g DW) and roots of A. adscendens (4.68 ± 0.015 mg/g DW). Caffeic acid was found most abundantly in A. officinalis (65.87 ± 0.021 mg/g DW), while β-sitosterol (9.36 ± 0.004 mg/g DW) and lupeol (5.91 ± 0.004 mg/g DW) were found highest in A. falcatus among the ten species. Overall findings showed that A. adscendens, A. densiflorus, A. falcatus and A. retrofractus have also rich quantity of examined secondary metabolites as compared to commercially important species (A. officinalis).
本研究分析了北印度十种芦笋的次生代谢物。采用经过验证的 HPTLC 方法,对芦笋节和根中的沙他苷 IV、沙他皂苷元、咖啡酸、β-谷甾醇和羽扇豆醇进行了定量研究。结果表明,天门冬的根茎(5.95 ± 0.024 mg/g(DW))中菝葜皂苷含量最高(11.20 ± 0.025 mg/g(DW))。在 A. densiflorus(6.72 ± 0.02 毫克/克(干重))和 A. adscendens(4.68 ± 0.015 毫克/克(干重))的根茎中,沙塔伐林 IV 的含量最高。咖啡酸在 A. officinalis 中含量最高(65.87 ± 0.021 mg/g DW),而 β-谷甾醇(9.36 ± 0.004 mg/g DW)和羽扇豆醇(5.91 ± 0.004 mg/g DW)在 A. falcatus 中含量最高。总体研究结果表明,与重要的商业物种(A. officinalis)相比,A. adscendens、A. densiflorus、A. falcatus 和 A. retrofractus 也具有丰富的次级代谢产物。
{"title":"Comparative HPTLC analysis of shatavarin IV, sarsasapogenin, caffeic acid, β-sitosterol and lupeol in roots and cladodes of ten <i>Asparagus</i> L. ssp. from North India.","authors":"Pooja Mawal, Manish Kapoor, Saroj Kumar Pradhan, Jyoti Rani, Raghbir Chand Gupta","doi":"10.1080/14786419.2024.2405883","DOIUrl":"https://doi.org/10.1080/14786419.2024.2405883","url":null,"abstract":"<p><p>In the present research, ten species of <i>Asparagus</i> from North India have been analysed for secondary metabolites. The quantitative study of shatavarin IV, sarsasapogenin, caffeic acid, β-sitosterol, and lupeol in the cladodes and roots of Asparagus was conducted using a validated HPTLC method. The content of sarsasapogenin was found highest in the cladodes of <i>A. racemosus</i> (11.20 ± 0.025 mg/g DW) and roots of <i>A. officinalis</i> (5.95 ± 0.024 mg/g DW). Shatavarin IV was found highest in cladodes of <i>A. densiflorus</i> (6.72 ± 0.02 mg/g DW) and roots of <i>A. adscendens</i> (4.68 ± 0.015 mg/g DW). Caffeic acid was found most abundantly in <i>A. officinalis</i> (65.87 ± 0.021 mg/g DW), while β-sitosterol (9.36 ± 0.004 mg/g DW) and lupeol (5.91 ± 0.004 mg/g DW) were found highest in <i>A. falcatus</i> among the ten species. Overall findings showed that <i>A. adscendens</i>, <i>A. densiflorus</i>, <i>A. falcatus</i> and <i>A. retrofractus</i> have also rich quantity of examined secondary metabolites as compared to commercially important species (<i>A. officinalis</i>).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-25DOI: 10.1080/14786419.2024.2406996
Islamudin Ahmad, Lizma Febrina, Baso Didik Hikmawan, Junaidin Junaidin, Herman Herman, Muhammad Faisal, Erwin Samsul, Iswahyudi Iswahyudi, Arsyik Ibrahim, Reza Yuridian Purwoko, Tia Okselni, Marissa Angelina, Amal Rezka Putra, Ratna Surya Alwi, Abdul Mun'im
The metabolite profile of the ethanol extract from Eleutherine bulbosa was assessed using the 1D NMR approach amalgamated with 2D NMR. E. bulbosa, an indigenous plant found in Indonesia, possesses considerable promise as a raw material for medicinal products. We examined the antioxidant capacity of the E. bulbosa extract using DPPH and ABTS methods. The antioxidant evaluation demonstrated that the ethanol extract exhibits strong antioxidant properties. Furthermore, we have successfully identified thirteen metabolites in the ethanol extract without separation. These metabolites include eleutherol A, eleutherol B, eleutherol C, eleuthione B, eleuthione C, hongconin, karwinaphthol, isoeleuthoside C, quinic acid, chlorogenic acid, isoeleutherin, cyanidin-3-o-β-glucopyranoside, and kadsuric acid. Metabolite Cyanidin-3-o-β-glucopyranoside (4.89 mM ± 0.02) was the highest metabolite contained in this extract. This result showed that NMR methods could detect and measure metabolites in the E. bulbosa ethanol extract without requiring separation.
采用一维核磁共振与二维核磁共振相结合的方法评估了榄香脂球藻乙醇提取物的代谢物概况。球茎榄香脂是印度尼西亚的一种本土植物,有望成为药用产品的原料。我们使用 DPPH 和 ABTS 方法检测了 E. bulbosa 提取物的抗氧化能力。抗氧化评估结果表明,乙醇提取物具有很强的抗氧化性。此外,我们还成功鉴定了乙醇提取物中的 13 种代谢物,这些代谢物未经分离。这些代谢物包括:榄香脂醇 A、榄香脂醇 B、榄香脂醇 C、榄香硫酮 B、榄香硫酮 C、红花苷、卡瓦胡椒酚、异榄香脂苷 C、奎宁酸、绿原酸、异榄香脂苷、花青素-3-O-β-吡喃葡萄糖苷和卡德酸。代谢物花青素-3-O-β-吡喃葡萄糖苷(4.89 mM ± 0.02)是该提取物中含量最高的代谢物。这一结果表明,核磁共振方法无需分离即可检测和测量球茎草乙醇提取物中的代谢物。
{"title":"NMR-based metabolic profiling and antioxidant activity of <i>Eleutherine bulbosa bulb</i> ethanol extract.","authors":"Islamudin Ahmad, Lizma Febrina, Baso Didik Hikmawan, Junaidin Junaidin, Herman Herman, Muhammad Faisal, Erwin Samsul, Iswahyudi Iswahyudi, Arsyik Ibrahim, Reza Yuridian Purwoko, Tia Okselni, Marissa Angelina, Amal Rezka Putra, Ratna Surya Alwi, Abdul Mun'im","doi":"10.1080/14786419.2024.2406996","DOIUrl":"https://doi.org/10.1080/14786419.2024.2406996","url":null,"abstract":"<p><p>The metabolite profile of the ethanol extract from <i>Eleutherine bulbosa</i> was assessed using the 1D NMR approach amalgamated with 2D NMR. <i>E. bulbosa,</i> an indigenous plant found in Indonesia, possesses considerable promise as a raw material for medicinal products. We examined the antioxidant capacity of the <i>E. bulbosa</i> extract using DPPH and ABTS methods. The antioxidant evaluation demonstrated that the ethanol extract exhibits strong antioxidant properties. Furthermore, we have successfully identified thirteen metabolites in the ethanol extract without separation. These metabolites include eleutherol A, eleutherol B, eleutherol C, eleuthione B, eleuthione C, hongconin, karwinaphthol, isoeleuthoside C, quinic acid, chlorogenic acid, isoeleutherin, cyanidin-3-o-β-glucopyranoside, and kadsuric acid. Metabolite Cyanidin-3-o-β-glucopyranoside (4.89 mM ± 0.02) was the highest metabolite contained in this extract. This result showed that NMR methods could detect and measure metabolites in the <i>E. bulbosa</i> ethanol extract without requiring separation.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To the best of our knowledge, this is the first chemical study of Guarea glomerulata that led to the isolation and characterisation of nine distinct compounds from its methanolic leaves extract including one new trinortriterpenoid glomerulatin along with eight known compounds amongst which five compounds namely azadirone, oleanolic acid, sericoside, cleomiscosin D and griffonin reported for the first time from the genus Guarea. All the isolated compounds have been evaluated in vitro for their antiplasmodial potency against the chloroquine-sensitive strain P. falciparum 3D7. The results showed that glomerulatin and azadirone were the most active compounds with IC50 values of 1.02 ± 0.2 μM and 1.48 ± 0.4 μM, respectively. This study enriches the chemistry of the genus Guarea and further supports the identification of Meliaceae plants as a good source of antiplasmodial candidates for the development of new potent drugs against malaria.
{"title":"Antiplasmodial specialised compounds from the leaves of <i>Guarea glomerulata</i> Harms (Meliaceae).","authors":"Gervais Mouthé Happi, Alain Tadjong Tcho, Klev Gaïtan Sikam, Guy-Paulin Mouthé Kemayou, Jacqueline Poffelie Kamegne, Dzouemo Liliane Clotilde, Jean Duplex Wansi","doi":"10.1080/14786419.2024.2407510","DOIUrl":"https://doi.org/10.1080/14786419.2024.2407510","url":null,"abstract":"<p><p>To the best of our knowledge, this is the first chemical study of <i>Guarea glomerulata</i> that led to the isolation and characterisation of nine distinct compounds from its methanolic leaves extract including one new trinortriterpenoid glomerulatin along with eight known compounds amongst which five compounds namely azadirone, oleanolic acid, sericoside, cleomiscosin D and griffonin reported for the first time from the genus <i>Guarea</i>. All the isolated compounds have been evaluated <i>in vitro</i> for their antiplasmodial potency against the chloroquine-sensitive strain <i>P. falciparum</i> 3D7. The results showed that glomerulatin and azadirone were the most active compounds with IC<sub>50</sub> values of 1.02 ± 0.2 <i>μ</i>M and 1.48 ± 0.4 <i>μ</i>M, respectively. This study enriches the chemistry of the genus <i>Guarea</i> and further supports the identification of Meliaceae plants as a good source of antiplasmodial candidates for the development of new potent drugs against malaria.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}