Pub Date : 2024-10-29DOI: 10.1038/s41563-024-02030-8
Wenmao Huang, Zongqing Lim, Jie Yan
Ions play a key role in governing the viscoelastic properties and mechanical stability of mitotic chromosomes.
离子在调节有丝分裂染色体的粘弹性和机械稳定性方面起着关键作用。
{"title":"Ions shaping the mechanics of chromosomes in mitosis","authors":"Wenmao Huang, Zongqing Lim, Jie Yan","doi":"10.1038/s41563-024-02030-8","DOIUrl":"10.1038/s41563-024-02030-8","url":null,"abstract":"Ions play a key role in governing the viscoelastic properties and mechanical stability of mitotic chromosomes.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1468-1470"},"PeriodicalIF":37.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1038/s41563-024-02033-5
Kristian Franze
Spring-like force sensors bioprinted in the developing neural tube of growing chick embryos enable the measurement of forces generated by embryonic tissues with micrometre-level resolution.
在发育中的小鸡胚胎神经管中生物打印的弹簧状力传感器能够以微米级的分辨率测量胚胎组织产生的力。
{"title":"Sensing the force in living embryos","authors":"Kristian Franze","doi":"10.1038/s41563-024-02033-5","DOIUrl":"10.1038/s41563-024-02033-5","url":null,"abstract":"Spring-like force sensors bioprinted in the developing neural tube of growing chick embryos enable the measurement of forces generated by embryonic tissues with micrometre-level resolution.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1471-1472"},"PeriodicalIF":37.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1038/s41563-024-02013-9
Hayoung Ko, Seungjin Lee, Ki Kang Kim
An ultraflat, single-crystal hexagonal boron nitride film enables the production of wafer-scale, ultrathin high-κ dielectrics for two-dimensional electronics, meeting the 2025 targets set by the International Roadmap for Devices and Systems.
{"title":"Ultraflat hexagonal boron nitride for high-κ dielectric integration","authors":"Hayoung Ko, Seungjin Lee, Ki Kang Kim","doi":"10.1038/s41563-024-02013-9","DOIUrl":"10.1038/s41563-024-02013-9","url":null,"abstract":"An ultraflat, single-crystal hexagonal boron nitride film enables the production of wafer-scale, ultrathin high-κ dielectrics for two-dimensional electronics, meeting the 2025 targets set by the International Roadmap for Devices and Systems.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1461-1462"},"PeriodicalIF":37.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1038/s41563-024-02029-1
Yu Han, Wenyuan Huang, Meng He, Bing An, Yinlin Chen, Xue Han, Lan An, Meredydd Kippax-Jones, Jiangnan Li, Yuhang Yang, Mark D. Frogley, Cheng Li, Danielle Crawshaw, Pascal Manuel, Svemir Rudić, Yongqiang Cheng, Ian Silverwood, Luke L. Daemen, Anibal J. Ramirez-Cuesta, Sarah J. Day, Stephen P. Thompson, Ben F. Spencer, Marek Nikiel, Daniel Lee, Martin Schröder, Sihai Yang
Capture of trace benzene is an important and challenging task. Metal–organic framework materials are promising sorbents for a variety of gases, but their limited capacity towards benzene at low concentration remains unresolved. Here we report the adsorption of trace benzene by decorating a structural defect in MIL-125-defect with single-atom metal centres to afford MIL-125-X (X = Mn, Fe, Co, Ni, Cu, Zn; MIL-125, Ti8O8(OH)4(BDC)6 where H2BDC is 1,4-benzenedicarboxylic acid). At 298 K, MIL-125-Zn exhibits a benzene uptake of 7.63 mmol g−1 at 1.2 mbar and 5.33 mmol g−1 at 0.12 mbar, and breakthrough experiments confirm the removal of trace benzene (from 5 to <0.5 ppm) from air (up to 111,000 min g−1 of metal–organic framework), even after exposure to moisture. The binding of benzene to the defect and open Zn(II) sites at low pressure has been visualized by diffraction, scattering and spectroscopy. This work highlights the importance of fine-tuning pore chemistry for designing adsorbents for the removal of air pollutants. Benzene is a genotoxic carcinogen with no safe level of exposure. Here, by creating and decorating a structural defect in a metal–organic framework to form MIL-125-Zn, a benzene uptake of 7.63 mmol g–1 at 1.2 mbar is observed due to binding to Zn(II) sites.
{"title":"Trace benzene capture by decoration of structural defects in metal–organic framework materials","authors":"Yu Han, Wenyuan Huang, Meng He, Bing An, Yinlin Chen, Xue Han, Lan An, Meredydd Kippax-Jones, Jiangnan Li, Yuhang Yang, Mark D. Frogley, Cheng Li, Danielle Crawshaw, Pascal Manuel, Svemir Rudić, Yongqiang Cheng, Ian Silverwood, Luke L. Daemen, Anibal J. Ramirez-Cuesta, Sarah J. Day, Stephen P. Thompson, Ben F. Spencer, Marek Nikiel, Daniel Lee, Martin Schröder, Sihai Yang","doi":"10.1038/s41563-024-02029-1","DOIUrl":"10.1038/s41563-024-02029-1","url":null,"abstract":"Capture of trace benzene is an important and challenging task. Metal–organic framework materials are promising sorbents for a variety of gases, but their limited capacity towards benzene at low concentration remains unresolved. Here we report the adsorption of trace benzene by decorating a structural defect in MIL-125-defect with single-atom metal centres to afford MIL-125-X (X = Mn, Fe, Co, Ni, Cu, Zn; MIL-125, Ti8O8(OH)4(BDC)6 where H2BDC is 1,4-benzenedicarboxylic acid). At 298 K, MIL-125-Zn exhibits a benzene uptake of 7.63 mmol g−1 at 1.2 mbar and 5.33 mmol g−1 at 0.12 mbar, and breakthrough experiments confirm the removal of trace benzene (from 5 to <0.5 ppm) from air (up to 111,000 min g−1 of metal–organic framework), even after exposure to moisture. The binding of benzene to the defect and open Zn(II) sites at low pressure has been visualized by diffraction, scattering and spectroscopy. This work highlights the importance of fine-tuning pore chemistry for designing adsorbents for the removal of air pollutants. Benzene is a genotoxic carcinogen with no safe level of exposure. Here, by creating and decorating a structural defect in a metal–organic framework to form MIL-125-Zn, a benzene uptake of 7.63 mmol g–1 at 1.2 mbar is observed due to binding to Zn(II) sites.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1531-1538"},"PeriodicalIF":37.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41563-024-02029-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1038/s41563-024-02050-4
Studies are shedding light on the mechanical properties of cellular tissues and their implications for biological processes.
研究揭示了细胞组织的机械特性及其对生物过程的影响。
{"title":"Tissues pushing on","authors":"","doi":"10.1038/s41563-024-02050-4","DOIUrl":"10.1038/s41563-024-02050-4","url":null,"abstract":"Studies are shedding light on the mechanical properties of cellular tissues and their implications for biological processes.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1457-1457"},"PeriodicalIF":37.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41563-024-02050-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-28DOI: 10.1038/s41563-024-02027-3
Julia Duque, Alessandra Bonfanti, Jonathan Fouchard, Lucia Baldauf, Sara R. Azenha, Emma Ferber, Andrew Harris, Elias H. Barriga, Alexandre J. Kabla, Guillaume Charras
To fulfil their function, epithelial tissues need to sustain mechanical stresses and avoid rupture. Although rupture is usually undesired, it is central to some developmental processes, for example, blastocoel formation. Nonetheless, little is known about tissue rupture because it is a multiscale phenomenon that necessitates comprehension of the interplay between mechanical forces and biological processes at the molecular and cellular scales. Here we characterize rupture in epithelial monolayers using mechanical measurements, live imaging and computational modelling. We show that despite consisting of only a single layer of cells, monolayers can withstand surprisingly large deformations, often accommodating several-fold increases in their length before rupture. At large deformation, epithelia increase their stiffness multiple fold in a process controlled by a supracellular network of keratin filaments. Perturbing the keratin network organization fragilized the monolayers and prevented strain-stiffening. Although the kinetics of adhesive bond rupture ultimately control tissue strength, tissue rheology and the history of deformation set the strain and stress at the onset of fracture. Tissue monolayers avoid rupture at large tensile stresses through a strain-stiffening process governed by intermediate keratin filaments.
{"title":"Rupture strength of living cell monolayers","authors":"Julia Duque, Alessandra Bonfanti, Jonathan Fouchard, Lucia Baldauf, Sara R. Azenha, Emma Ferber, Andrew Harris, Elias H. Barriga, Alexandre J. Kabla, Guillaume Charras","doi":"10.1038/s41563-024-02027-3","DOIUrl":"10.1038/s41563-024-02027-3","url":null,"abstract":"To fulfil their function, epithelial tissues need to sustain mechanical stresses and avoid rupture. Although rupture is usually undesired, it is central to some developmental processes, for example, blastocoel formation. Nonetheless, little is known about tissue rupture because it is a multiscale phenomenon that necessitates comprehension of the interplay between mechanical forces and biological processes at the molecular and cellular scales. Here we characterize rupture in epithelial monolayers using mechanical measurements, live imaging and computational modelling. We show that despite consisting of only a single layer of cells, monolayers can withstand surprisingly large deformations, often accommodating several-fold increases in their length before rupture. At large deformation, epithelia increase their stiffness multiple fold in a process controlled by a supracellular network of keratin filaments. Perturbing the keratin network organization fragilized the monolayers and prevented strain-stiffening. Although the kinetics of adhesive bond rupture ultimately control tissue strength, tissue rheology and the history of deformation set the strain and stress at the onset of fracture. Tissue monolayers avoid rupture at large tensile stresses through a strain-stiffening process governed by intermediate keratin filaments.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1563-1574"},"PeriodicalIF":37.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41563-024-02027-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1038/s41563-024-02022-8
Gary P. T. Choi
A technique has been developed for automatically discovering mechanical metamaterials with desired nonlinear dynamic responses.
我们开发了一种技术，用于自动发现具有理想非线性动态响应的机械超材料。
{"title":"Designing flexible mechanical metamaterials with complex functionalities","authors":"Gary P. T. Choi","doi":"10.1038/s41563-024-02022-8","DOIUrl":"10.1038/s41563-024-02022-8","url":null,"abstract":"A technique has been developed for automatically discovering mechanical metamaterials with desired nonlinear dynamic responses.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1458-1460"},"PeriodicalIF":37.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-09DOI: 10.1038/s41563-024-02018-4
Mikhail I. Katsnelson
Twist-angle control of spin–charge interconversion in a graphene/WSe2 heterostructure is demonstrated.
演示了石墨烯/WSe2 异质结构中自旋电荷互转的扭角控制。
{"title":"Tunable spin–orbit physics in van der Waals heterostructures","authors":"Mikhail I. Katsnelson","doi":"10.1038/s41563-024-02018-4","DOIUrl":"10.1038/s41563-024-02018-4","url":null,"abstract":"Twist-angle control of spin–charge interconversion in a graphene/WSe2 heterostructure is demonstrated.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1463-1464"},"PeriodicalIF":37.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-09DOI: 10.1038/s41563-024-02019-3
Louis S. Prahl, Jiageng Liu, John M. Viola, Aria Zheyuan Huang, Trevor J. Chan, Gabriela Hayward-Lara, Catherine M. Porter, Chenjun Shi, Jitao Zhang, Alex J. Hughes
Urinary collecting tubules form during kidney embryogenesis through the branching of the ureteric bud epithelium. A travelling mesenchyme niche of nephron progenitor cells caps each branching ureteric bud tip. These ‘tip domain’ niches pack more closely over developmental time and their number relates to nephron endowment at birth. Yet, how the crowded tissue environment impacts niche number and cell decision-making remains unclear. Here, through experiments and mathematical modelling, we show that niche packing conforms to physical limitations imposed by kidney curvature. We relate packing geometries to rigidity theory to predict a stiffening transition starting at embryonic day 15 in the mouse, validated by micromechanical analysis. Using a method to estimate tip domain ‘ages’ relative to their most recent branch events, we find that new niches overcome mechanical resistance as they branch and displace neighbours. This creates rhythmic mechanical stress in the niche. These findings expand our understanding of kidney development and inform engineering strategies for synthetic regenerative tissues. Geometric packing of tubules in the developing kidney urinary collecting system leads to tissue stiffening and rhythmic mechanical stresses local to nephron-forming niches that synchronize with tubule branching.
{"title":"Jamming of nephron-forming niches in the developing mouse kidney creates cyclical mechanical stresses","authors":"Louis S. Prahl, Jiageng Liu, John M. Viola, Aria Zheyuan Huang, Trevor J. Chan, Gabriela Hayward-Lara, Catherine M. Porter, Chenjun Shi, Jitao Zhang, Alex J. Hughes","doi":"10.1038/s41563-024-02019-3","DOIUrl":"10.1038/s41563-024-02019-3","url":null,"abstract":"Urinary collecting tubules form during kidney embryogenesis through the branching of the ureteric bud epithelium. A travelling mesenchyme niche of nephron progenitor cells caps each branching ureteric bud tip. These ‘tip domain’ niches pack more closely over developmental time and their number relates to nephron endowment at birth. Yet, how the crowded tissue environment impacts niche number and cell decision-making remains unclear. Here, through experiments and mathematical modelling, we show that niche packing conforms to physical limitations imposed by kidney curvature. We relate packing geometries to rigidity theory to predict a stiffening transition starting at embryonic day 15 in the mouse, validated by micromechanical analysis. Using a method to estimate tip domain ‘ages’ relative to their most recent branch events, we find that new niches overcome mechanical resistance as they branch and displace neighbours. This creates rhythmic mechanical stress in the niche. These findings expand our understanding of kidney development and inform engineering strategies for synthetic regenerative tissues. Geometric packing of tubules in the developing kidney urinary collecting system leads to tissue stiffening and rhythmic mechanical stresses local to nephron-forming niches that synchronize with tubule branching.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 11","pages":"1582-1591"},"PeriodicalIF":37.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41563-024-02005-9
Haitao Qing, Fangjie Qi, Jie Yin
A miniature hydrogel launcher inspired by the squirting cucumber achieves record-high jumping height through water evaporation and fracture-driven power amplification.
受喷水黄瓜启发的微型水凝胶发射器通过水蒸发和断裂驱动的功率放大实现了创纪录的跳跃高度。
{"title":"Squirting-cucumber-inspired miniature explosive hydrogel launcher","authors":"Haitao Qing, Fangjie Qi, Jie Yin","doi":"10.1038/s41563-024-02005-9","DOIUrl":"10.1038/s41563-024-02005-9","url":null,"abstract":"A miniature hydrogel launcher inspired by the squirting cucumber achieves record-high jumping height through water evaporation and fracture-driven power amplification.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"23 10","pages":"1315-1317"},"PeriodicalIF":37.2,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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