Pub Date : 2026-01-27DOI: 10.1038/s41563-026-02481-1
A Lindsay Greer
{"title":"Exploiting and taming the structural instability for computer memories.","authors":"A Lindsay Greer","doi":"10.1038/s41563-026-02481-1","DOIUrl":"https://doi.org/10.1038/s41563-026-02481-1","url":null,"abstract":"","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"42 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1038/s41563-025-02467-5
Mingyi Zhang, Benjamin A. Legg, Benjamin A. Helfrecht, Yuanzhong Zhang, Shuai Tan, Ying Xia, Rae Karell Yodong, Monica Iepure, Venkateshkumar Prabhakaran, Peter J. Pauzauskie, Younjin Min, Christopher J. Mundy, James J. De Yoreo
{"title":"How charge frustration causes ion ordering and microphase separation at surfaces","authors":"Mingyi Zhang, Benjamin A. Legg, Benjamin A. Helfrecht, Yuanzhong Zhang, Shuai Tan, Ying Xia, Rae Karell Yodong, Monica Iepure, Venkateshkumar Prabhakaran, Peter J. Pauzauskie, Younjin Min, Christopher J. Mundy, James J. De Yoreo","doi":"10.1038/s41563-025-02467-5","DOIUrl":"https://doi.org/10.1038/s41563-025-02467-5","url":null,"abstract":"","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"30 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1038/s41563-025-02464-8
Hailong Huang, Prashant Singh, Duane D. Johnson, Dishant Beniwal, Pratik K. Ray, Gaoyuan Ouyang, Luke Gaydos, Trevor Riedemann, Tirthesh Ingale, Vishal Soni, Rajarshi Banerjee, Thomas W. Scharf, Ping Lu, Frank W. DelRio, Andrew B. Kustas, John A. Sharon, Ryan Deacon, Syed I. A. Jalali, Michael Patullo, Sharon Park, Kevin J. Hemker, Ryan T. Ott, Nicolas Argibay
{"title":"Achieving high tensile strength and ductility in refractory alloys by tuning electronic structure","authors":"Hailong Huang, Prashant Singh, Duane D. Johnson, Dishant Beniwal, Pratik K. Ray, Gaoyuan Ouyang, Luke Gaydos, Trevor Riedemann, Tirthesh Ingale, Vishal Soni, Rajarshi Banerjee, Thomas W. Scharf, Ping Lu, Frank W. DelRio, Andrew B. Kustas, John A. Sharon, Ryan Deacon, Syed I. A. Jalali, Michael Patullo, Sharon Park, Kevin J. Hemker, Ryan T. Ott, Nicolas Argibay","doi":"10.1038/s41563-025-02464-8","DOIUrl":"https://doi.org/10.1038/s41563-025-02464-8","url":null,"abstract":"","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"7 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1038/s41563-025-02469-3
Marco Abbarchi, David Grosso, Badre Kerzabi, George Palikaras
{"title":"Leveraging the power of metasurfaces.","authors":"Marco Abbarchi, David Grosso, Badre Kerzabi, George Palikaras","doi":"10.1038/s41563-025-02469-3","DOIUrl":"https://doi.org/10.1038/s41563-025-02469-3","url":null,"abstract":"","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":" ","pages":""},"PeriodicalIF":38.5,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1038/s41563-025-02462-w
Valentin Gensbittel, Zeynep Yesilata, Louis Bochler, Gautier Follain, Laurie Nemoz-Billet, Olivier Lefebvre, Klemens Uhlmann, Annabel Larnicol, Giulia E M Ammirati, Sébastien Harlepp, Ruchi Goswami, Salvatore Girardo, Laetitia Paulen, Vincent Hyenne, Vincent Mittelheisser, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Guillaume Belthier, Julie Pannequin, Martin Kräter, Daniel J Müller, Daniel Balzani, Jochen Guck, Naël Osmani, Jacky G Goetz
Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such microenvironments is not fully understood. Here we report that the deformability of CTCs affects their haematogenous dissemination and identify mechanical phenotypes that favour metastatic extravasation. Combining intravital microscopy with CTC-mimicking elastic beads, mechanical tuning in tumour lines and profiling of tumour-patient-derived cells, we demonstrate that the inherent mechanical properties of circulating objects dictate their ability to enter constraining vessels. We identify cellular viscosity as a rheostat of CTC circulation and arrest, and show that cellular viscosity is crucial for efficient extravasation. Moreover, we find that mechanical properties that favour extravasation and subsequent metastatic outgrowth can be opposite. Altogether, our results establish CTC viscosity as a key biomechanical parameter that shapes several steps of metastasis.
{"title":"Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells.","authors":"Valentin Gensbittel, Zeynep Yesilata, Louis Bochler, Gautier Follain, Laurie Nemoz-Billet, Olivier Lefebvre, Klemens Uhlmann, Annabel Larnicol, Giulia E M Ammirati, Sébastien Harlepp, Ruchi Goswami, Salvatore Girardo, Laetitia Paulen, Vincent Hyenne, Vincent Mittelheisser, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Guillaume Belthier, Julie Pannequin, Martin Kräter, Daniel J Müller, Daniel Balzani, Jochen Guck, Naël Osmani, Jacky G Goetz","doi":"10.1038/s41563-025-02462-w","DOIUrl":"https://doi.org/10.1038/s41563-025-02462-w","url":null,"abstract":"<p><p>Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such microenvironments is not fully understood. Here we report that the deformability of CTCs affects their haematogenous dissemination and identify mechanical phenotypes that favour metastatic extravasation. Combining intravital microscopy with CTC-mimicking elastic beads, mechanical tuning in tumour lines and profiling of tumour-patient-derived cells, we demonstrate that the inherent mechanical properties of circulating objects dictate their ability to enter constraining vessels. We identify cellular viscosity as a rheostat of CTC circulation and arrest, and show that cellular viscosity is crucial for efficient extravasation. Moreover, we find that mechanical properties that favour extravasation and subsequent metastatic outgrowth can be opposite. Altogether, our results establish CTC viscosity as a key biomechanical parameter that shapes several steps of metastasis.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":" ","pages":""},"PeriodicalIF":38.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1038/s41563-025-02463-9
Eva K Pillai, Sudipta Mukherjee, Niklas Gampl, Ross J McGinn, Katrin A Mooslehner, Julia M Becker, Alexander K Winkel, Amelia J Thompson, Kristian Franze
Biological processes are regulated by chemical and mechanical signals, yet how these signalling modalities interact remains poorly understood. Here we identify a crosstalk between tissue stiffness and long-range chemical signalling in the developing Xenopus laevis brain. Targeted knockdown of the mechanosensitive ion channel Piezo1 in retinal ganglion cells or in the brain tissue surrounding retinal ganglion cells causes pathfinding errors in vivo. In the brain parenchyma, Piezo1 downregulation decreases the expression of the diffusive long-range chemical guidance cues Semaphorin3A (Sema3A) and Slit1, which instruct turning responses in distant cells. Furthermore, Piezo1 knockdown results in tissue softening due to reduced expression of the adhesion proteins NCAM1 and N-cadherin. Targeted depletion of NCAM1 and N-cadherin similarly reduces tissue stiffness and Sema3A expression. Conversely, increasing environmental stiffness ex vivo enhances tissue-level force generation and Slit1 and Sema3A expression. Finally, in vivo stiffening of soft brain regions induces ectopic Sema3A production via a Piezo1-dependent mechanism. Overall, these findings demonstrate that tissue mechanics locally modulates the availability of diffusive, long-range chemical signals, thus influencing cell function at sites distant from the mechanical cue.
{"title":"Long-range chemical signalling in vivo is regulated by mechanical signals.","authors":"Eva K Pillai, Sudipta Mukherjee, Niklas Gampl, Ross J McGinn, Katrin A Mooslehner, Julia M Becker, Alexander K Winkel, Amelia J Thompson, Kristian Franze","doi":"10.1038/s41563-025-02463-9","DOIUrl":"https://doi.org/10.1038/s41563-025-02463-9","url":null,"abstract":"<p><p>Biological processes are regulated by chemical and mechanical signals, yet how these signalling modalities interact remains poorly understood. Here we identify a crosstalk between tissue stiffness and long-range chemical signalling in the developing Xenopus laevis brain. Targeted knockdown of the mechanosensitive ion channel Piezo1 in retinal ganglion cells or in the brain tissue surrounding retinal ganglion cells causes pathfinding errors in vivo. In the brain parenchyma, Piezo1 downregulation decreases the expression of the diffusive long-range chemical guidance cues Semaphorin3A (Sema3A) and Slit1, which instruct turning responses in distant cells. Furthermore, Piezo1 knockdown results in tissue softening due to reduced expression of the adhesion proteins NCAM1 and N-cadherin. Targeted depletion of NCAM1 and N-cadherin similarly reduces tissue stiffness and Sema3A expression. Conversely, increasing environmental stiffness ex vivo enhances tissue-level force generation and Slit1 and Sema3A expression. Finally, in vivo stiffening of soft brain regions induces ectopic Sema3A production via a Piezo1-dependent mechanism. Overall, these findings demonstrate that tissue mechanics locally modulates the availability of diffusive, long-range chemical signals, thus influencing cell function at sites distant from the mechanical cue.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":" ","pages":""},"PeriodicalIF":38.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phase engineering is of vital importance for determining the material functionalities and expanding the material library. However, the controllable and scalable phase transition of transition metal chalcogenides remains extremely challenging. The microscopic observation of the phase evolution pathway is an essential prerequisite for understanding the phase transition mechanism. Here we atomically observe a non-stoichiometric phase evolution process in large-scale superconducting PdTe2 films under heating through in situ scanning transmission electron microscopy. The unprecedented phase transition from PdTe2 to PdTe via atomic reconstruction is evidenced and theoretically verified by our machine learning molecular dynamics simulations. In particular, forming the intermediate state of PdTe2/PdTe heterostructure during the phase transition robustly generates giant-helicity-dependent terahertz emission due to inversion symmetry breaking. Our results not only provide insights into the atomic reconstruction in transition metal chalcogenides but also offer a general strategy for the fabrication of large-area transition metal monochalcogenide films and heterostructures, potentially applicable for various device applications.
{"title":"Large-area non-stoichiometric phase transition in transition metal chalcogenide films.","authors":"Zhongqiang Chen,Jin-An Shi,Jianqi Huang,Yuan Chang,Ruijie Xu,Kankan Xu,Xu Zhang,Xudong Liu,Da Tian,Yong Zhang,Sajjad Ali,Xingze Dai,Gan Liu,Zheng Dai,Shuai Zhang,Fucong Fei,Xiaoxiang Xi,Yufeng Hao,Liang He,Wu Zhou,Teng Yang,Junfeng Gao,Feng Ding,Yongbing Xu,Fengqi Song,Biaobing Jin,Xinran Wang,Yi Shi,Rong Zhang,Xuefeng Wang","doi":"10.1038/s41563-025-02471-9","DOIUrl":"https://doi.org/10.1038/s41563-025-02471-9","url":null,"abstract":"Phase engineering is of vital importance for determining the material functionalities and expanding the material library. However, the controllable and scalable phase transition of transition metal chalcogenides remains extremely challenging. The microscopic observation of the phase evolution pathway is an essential prerequisite for understanding the phase transition mechanism. Here we atomically observe a non-stoichiometric phase evolution process in large-scale superconducting PdTe2 films under heating through in situ scanning transmission electron microscopy. The unprecedented phase transition from PdTe2 to PdTe via atomic reconstruction is evidenced and theoretically verified by our machine learning molecular dynamics simulations. In particular, forming the intermediate state of PdTe2/PdTe heterostructure during the phase transition robustly generates giant-helicity-dependent terahertz emission due to inversion symmetry breaking. Our results not only provide insights into the atomic reconstruction in transition metal chalcogenides but also offer a general strategy for the fabrication of large-area transition metal monochalcogenide films and heterostructures, potentially applicable for various device applications.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"57 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1038/s41563-025-02459-5
Ting Zhu,Wen Chen
Additive manufacturing is reshaping the production of engineering components in diverse industries, such as the automotive, aerospace, defence and biomedical sectors, by offering outstanding design and fabrication flexibility. The non-equilibrium processing conditions inherent to additive manufacturing yield materials with unique microstructures and tailored mechanical properties that are often unattainable through conventional routes. This Review highlights recent advances in additively manufactured metals that show distinctive mechanical behaviours, including strength-ductility synergy, microstresses and gradient plasticity, fracture and fatigue resistance, and high-temperature creep performance. We examine the deformation mechanisms and micromechanical effects arising from the heterogeneous microstructures produced by additive manufacturing to guide the design of high-performance structural materials. Furthermore, we discuss critical research needs and emerging opportunities in processing control, alloy design, advanced characterization, computational modelling and machine learning aimed at achieving exceptional mechanical properties in additively manufactured metals.
{"title":"Mechanical behaviour of additively manufactured metals.","authors":"Ting Zhu,Wen Chen","doi":"10.1038/s41563-025-02459-5","DOIUrl":"https://doi.org/10.1038/s41563-025-02459-5","url":null,"abstract":"Additive manufacturing is reshaping the production of engineering components in diverse industries, such as the automotive, aerospace, defence and biomedical sectors, by offering outstanding design and fabrication flexibility. The non-equilibrium processing conditions inherent to additive manufacturing yield materials with unique microstructures and tailored mechanical properties that are often unattainable through conventional routes. This Review highlights recent advances in additively manufactured metals that show distinctive mechanical behaviours, including strength-ductility synergy, microstresses and gradient plasticity, fracture and fatigue resistance, and high-temperature creep performance. We examine the deformation mechanisms and micromechanical effects arising from the heterogeneous microstructures produced by additive manufacturing to guide the design of high-performance structural materials. Furthermore, we discuss critical research needs and emerging opportunities in processing control, alloy design, advanced characterization, computational modelling and machine learning aimed at achieving exceptional mechanical properties in additively manufactured metals.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"269 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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