Pub Date : 2025-10-21DOI: 10.1038/s41578-025-00855-6
Giulia Pacchioni
An article in Nature Communications presents a digital platform that integrates the design, fabrication and optimization of catalytic reactors, combining machine learning and 3D printing.
{"title":"A platform that designs, prints and tests catalytic reactors","authors":"Giulia Pacchioni","doi":"10.1038/s41578-025-00855-6","DOIUrl":"10.1038/s41578-025-00855-6","url":null,"abstract":"An article in Nature Communications presents a digital platform that integrates the design, fabrication and optimization of catalytic reactors, combining machine learning and 3D printing.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 11","pages":"805-805"},"PeriodicalIF":86.2,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145381870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-17DOI: 10.1038/s41578-025-00852-9
Sihan Xiong, Chuang Liu
mRNA-loaded lipid nanoparticles have gained recognition as a promising therapeutic platform against a wide range of diseases. However, a key component of mRNA-loaded lipid nanoparticles, the polyethylene glycol-conjugated lipid, presents inherent barriers to their therapeutic success. Emerging strategies are now offering potential ways to overcome these limitations.
{"title":"Breaking the PEG barrier to boost mRNA-LNP therapeutics","authors":"Sihan Xiong, Chuang Liu","doi":"10.1038/s41578-025-00852-9","DOIUrl":"10.1038/s41578-025-00852-9","url":null,"abstract":"mRNA-loaded lipid nanoparticles have gained recognition as a promising therapeutic platform against a wide range of diseases. However, a key component of mRNA-loaded lipid nanoparticles, the polyethylene glycol-conjugated lipid, presents inherent barriers to their therapeutic success. Emerging strategies are now offering potential ways to overcome these limitations.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 11","pages":"799-800"},"PeriodicalIF":86.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1038/s41578-025-00850-x
Hongtao Sun
The development of safer, cheaper and more durable all-solid-state batteries demands a fundamental rethinking of composite cathode design. All-in-one cathode materials that integrate ionic conductivity, electronic conductivity and redox activity within a single phase redefine battery architecture by unifying electrochemical roles in one material.
{"title":"All-in-one cathode design for all-solid-state batteries","authors":"Hongtao Sun","doi":"10.1038/s41578-025-00850-x","DOIUrl":"10.1038/s41578-025-00850-x","url":null,"abstract":"The development of safer, cheaper and more durable all-solid-state batteries demands a fundamental rethinking of composite cathode design. All-in-one cathode materials that integrate ionic conductivity, electronic conductivity and redox activity within a single phase redefine battery architecture by unifying electrochemical roles in one material.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"11 1","pages":"2-4"},"PeriodicalIF":86.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145381875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1038/s41578-025-00849-4
Yoana Nuevo, Eva Hemmrich, Rosa Virto, Adela Nuñez, Celia Cerrato, René Thürmer, Diego Alejandro Dri, Scott McNeil, Tomáš Boráň
Horizon scanning is a strategic tool used by regulatory bodies to identify emerging technologies and guide decision-making. In its latest report on nanomedicines, the European Union Innovation Network presents key recommendations that illustrate the current dynamics between researchers and regulators and how strengthening this relationship could accelerate the translation of nanotechnology-based medicines into patient benefit.
{"title":"Horizon scanning to shape nanomedicines through researcher–regulator collaboration","authors":"Yoana Nuevo, Eva Hemmrich, Rosa Virto, Adela Nuñez, Celia Cerrato, René Thürmer, Diego Alejandro Dri, Scott McNeil, Tomáš Boráň","doi":"10.1038/s41578-025-00849-4","DOIUrl":"10.1038/s41578-025-00849-4","url":null,"abstract":"Horizon scanning is a strategic tool used by regulatory bodies to identify emerging technologies and guide decision-making. In its latest report on nanomedicines, the European Union Innovation Network presents key recommendations that illustrate the current dynamics between researchers and regulators and how strengthening this relationship could accelerate the translation of nanotechnology-based medicines into patient benefit.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 12","pages":"877-879"},"PeriodicalIF":86.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145381876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1038/s41578-025-00845-8
Materials researchers are trained to innovate and create. But now that it is clear the world has too much stuff, what is the path forward?
材料研究人员接受过创新和创造的培训。但现在很明显，世界上有太多的东西，前进的道路是什么？
{"title":"The materials we make don’t just go ‘away’","authors":"","doi":"10.1038/s41578-025-00845-8","DOIUrl":"10.1038/s41578-025-00845-8","url":null,"abstract":"Materials researchers are trained to innovate and create. But now that it is clear the world has too much stuff, what is the path forward?","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 10","pages":"713-714"},"PeriodicalIF":86.2,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41578-025-00845-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1038/s41578-025-00846-7
Sreenivas Raguraman, Adam Griebel, Maitreyee Sharma Priyadarshini, Paulette Clancy, Timothy P. Weihs
Despite transformative advances in materials discovery, real-world performance still hinges on an often-overlooked variable: processing. To bridge the gap between discovery and deployment, processing must be elevated from an afterthought to a central pillar in design frameworks, data generation and machine learning.
{"title":"A call to elevate the role of processing in AI-driven materials design","authors":"Sreenivas Raguraman, Adam Griebel, Maitreyee Sharma Priyadarshini, Paulette Clancy, Timothy P. Weihs","doi":"10.1038/s41578-025-00846-7","DOIUrl":"10.1038/s41578-025-00846-7","url":null,"abstract":"Despite transformative advances in materials discovery, real-world performance still hinges on an often-overlooked variable: processing. To bridge the gap between discovery and deployment, processing must be elevated from an afterthought to a central pillar in design frameworks, data generation and machine learning.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 12","pages":"875-876"},"PeriodicalIF":86.2,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145652871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-24DOI: 10.1038/s41578-025-00841-y
Savannah Weihang Zhang (, ), David A. Edwards, Robert Langer, Ke Cheng
Airway mucus has a crucial role in protecting against inhaled pathogens and regulating water homeostasis, but it can also diminish the efficacy of therapeutic pulmonary delivery. Recent development in inhalable materials and biologics has introduced strategies to modify mucus properties, strengthening mucosal protection, advancing drug delivery and targeting and supporting effective water regulation. In this Review, we thoroughly examine the structure and function of airway mucus, along with the challenges and opportunities it presents for inhaled treatments. We explore new methods that enhance the protective role of mucus through physical reinforcement, pathogen neutralization, muco-trapping and rehydration, as well as strategies that overcome the mucus barrier to improve drug delivery, including physical modulation, mucoadhesive design, muco-penetrating design, mucolytics and active targeting. Finally, we discuss the clinical implications of these promising strategies, emphasizing the need to balance mucosal function with optimized therapeutic delivery. We seek to explore prospective ways to improve inhalation therapies for both infectious and chronic lung diseases by reviewing recent progress in inhalable materials and biologics. Airway mucus complicates treatment of respiratory disease by both defending the lungs and hindering inhaled drugs to cross the barriers. This Review explores translational advances in inhalable materials and biologics that enhance mucus protection or drug penetration.
{"title":"Inhalable materials and biologics for lung defence and drug delivery","authors":"Savannah Weihang Zhang \u0000 (, ), David A. Edwards, Robert Langer, Ke Cheng","doi":"10.1038/s41578-025-00841-y","DOIUrl":"10.1038/s41578-025-00841-y","url":null,"abstract":"Airway mucus has a crucial role in protecting against inhaled pathogens and regulating water homeostasis, but it can also diminish the efficacy of therapeutic pulmonary delivery. Recent development in inhalable materials and biologics has introduced strategies to modify mucus properties, strengthening mucosal protection, advancing drug delivery and targeting and supporting effective water regulation. In this Review, we thoroughly examine the structure and function of airway mucus, along with the challenges and opportunities it presents for inhaled treatments. We explore new methods that enhance the protective role of mucus through physical reinforcement, pathogen neutralization, muco-trapping and rehydration, as well as strategies that overcome the mucus barrier to improve drug delivery, including physical modulation, mucoadhesive design, muco-penetrating design, mucolytics and active targeting. Finally, we discuss the clinical implications of these promising strategies, emphasizing the need to balance mucosal function with optimized therapeutic delivery. We seek to explore prospective ways to improve inhalation therapies for both infectious and chronic lung diseases by reviewing recent progress in inhalable materials and biologics. Airway mucus complicates treatment of respiratory disease by both defending the lungs and hindering inhaled drugs to cross the barriers. This Review explores translational advances in inhalable materials and biologics that enhance mucus protection or drug penetration.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"11 2","pages":"90-116"},"PeriodicalIF":86.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-19DOI: 10.1038/s41578-025-00838-7
Kenneth E. Madsen, Matthew T. Flavin, John A. Rogers
Historic and ongoing efforts in ecology and environmental science have highlighted the pressing need to monitor the health, sustainability and productivity of global and local ecosystems. Interest in these areas reflects a need both to determine the suitability of environments to support human activity (settlement, agriculture and industry) and to evaluate the impacts of such anthropogenic action. Of interest are chemical, biological and physical factors that reduce ecosystem viability owing to human intervention. Evaluating these factors and their impact on global health, ecological stability and resource availability demands improvements to existing environmental sensing technologies. Current methods to quantify chemical pollutants, biological factors and deleterious physical conditions affecting target ecosystems suffer from lack of automation and narrow spatiotemporal range. Recent advances in materials science, chemistry, electronics and robotics offer solutions to this problem. A vision emerges for fully autonomous, networked and ecoresorbable sensing systems that can be deployed over large aerial, terrestrial and aquatic environments. This Review describes ongoing efforts in these areas, focusing on materials advances supporting the accurate quantification of environmental factors with apparatus that accommodates full or partial device resorption. Discussion begins with an overview of hazards affecting global ecosystems, followed by a description of existing detection methods to quantify their severity. We proceed with an exploration of existing and developing technologies affecting sensor dispersion, motility, communication and power. Finally, we describe exciting recent efforts in the development of environmentally degradable materials that could prove beneficial in the realization of massively distributed (millions of individual sensors) transient sensor networks. Accurate, spatiotemporally resolved monitoring of environments and ecosystems serves as the starting point to both identify and remedy natural or anthropogenic environmental hazards. This Review covers materials science advances supporting a new paradigm in environmental sensing: distributed networks of sensing elements capable of system-level profiling with the possibility of harmless environmental resorption after a predetermined recording period.
{"title":"Materials advances for distributed environmental sensor networks at scale","authors":"Kenneth E. Madsen, Matthew T. Flavin, John A. Rogers","doi":"10.1038/s41578-025-00838-7","DOIUrl":"10.1038/s41578-025-00838-7","url":null,"abstract":"Historic and ongoing efforts in ecology and environmental science have highlighted the pressing need to monitor the health, sustainability and productivity of global and local ecosystems. Interest in these areas reflects a need both to determine the suitability of environments to support human activity (settlement, agriculture and industry) and to evaluate the impacts of such anthropogenic action. Of interest are chemical, biological and physical factors that reduce ecosystem viability owing to human intervention. Evaluating these factors and their impact on global health, ecological stability and resource availability demands improvements to existing environmental sensing technologies. Current methods to quantify chemical pollutants, biological factors and deleterious physical conditions affecting target ecosystems suffer from lack of automation and narrow spatiotemporal range. Recent advances in materials science, chemistry, electronics and robotics offer solutions to this problem. A vision emerges for fully autonomous, networked and ecoresorbable sensing systems that can be deployed over large aerial, terrestrial and aquatic environments. This Review describes ongoing efforts in these areas, focusing on materials advances supporting the accurate quantification of environmental factors with apparatus that accommodates full or partial device resorption. Discussion begins with an overview of hazards affecting global ecosystems, followed by a description of existing detection methods to quantify their severity. We proceed with an exploration of existing and developing technologies affecting sensor dispersion, motility, communication and power. Finally, we describe exciting recent efforts in the development of environmentally degradable materials that could prove beneficial in the realization of massively distributed (millions of individual sensors) transient sensor networks. Accurate, spatiotemporally resolved monitoring of environments and ecosystems serves as the starting point to both identify and remedy natural or anthropogenic environmental hazards. This Review covers materials science advances supporting a new paradigm in environmental sensing: distributed networks of sensing elements capable of system-level profiling with the possibility of harmless environmental resorption after a predetermined recording period.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"11 1","pages":"26-49"},"PeriodicalIF":86.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-16DOI: 10.1038/s41578-025-00839-6
Feng He (, ), Avelino Corma, Lichen Liu (, )
Zeolites are widely used in catalysis and separation, yet their crystallization process remains poorly understood. Emerging tools have the potential to enable a multiscale understanding of how crystallization influences the structural features of zeolite materials, unlocking their precise control.
{"title":"Multiscale understanding and precise control of zeolite crystallization","authors":"Feng He \u0000 (, ), Avelino Corma, Lichen Liu \u0000 (, )","doi":"10.1038/s41578-025-00839-6","DOIUrl":"10.1038/s41578-025-00839-6","url":null,"abstract":"Zeolites are widely used in catalysis and separation, yet their crystallization process remains poorly understood. Emerging tools have the potential to enable a multiscale understanding of how crystallization influences the structural features of zeolite materials, unlocking their precise control.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"11 2","pages":"84-86"},"PeriodicalIF":86.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-12DOI: 10.1038/s41578-025-00832-z
Tianya Zhou (, ), Chuan Xu (, ), Wencai Ren (, )
Two-dimensional materials, such as graphene, hexagonal boron nitride and transition metal dichalcogenides, are normally limited by the known 3D bulk materials. The design and synthesis of entirely new 2D materials, particularly van der Waals (vdW) layered materials, would significantly expand the properties and functionalities of 2D materials. In 2020, a novel vdW layered material, MoSi2N4, was synthesized by passivating the surface of 2D non-layered molybdenum nitride with the addition of elemental silicon, which has since opened up a new vdW materials family with the general formula MA2Z4. To date, over a hundred MA2Z4 materials and their derivatives have been predicted, in addition to the synthesized MSi2N4 (M = Mo, W), encompassing metals, semiconductors, superconductors, topological insulators, ferroelectrics and ferromagnets, owing to the diversity of elements and structures in MA2Z4. Such materials exhibit a variety of exceptional electronic, optical, thermal, mechanical, ferroelectric and magnetic properties, and they are promising for applications in electronic and optoelectronic devices, electrocatalysis, photocatalysis and batteries. Over the past 4 years, the MoSi2N4 materials family has rapidly emerged as a key research frontier in materials science. In this Review, we summarize recent advances in the investigation of materials in the MoSi2N4 family, covering their crystal structure, synthesis methods, fundamental properties and potential applications, and provide an outlook on future research directions. The van der Waals MA2Z4 materials are a rapidly growing class of 2D materials with diverse electronic phases. This Review explores the structure, synthesis, properties and diverse applications of the emerging MA2Z4 family, highlighting their potential across electronics, catalysis and energy storage.
{"title":"The van der Waals MoSi2N4 materials family","authors":"Tianya Zhou \u0000 (, ), Chuan Xu \u0000 (, ), Wencai Ren \u0000 (, )","doi":"10.1038/s41578-025-00832-z","DOIUrl":"10.1038/s41578-025-00832-z","url":null,"abstract":"Two-dimensional materials, such as graphene, hexagonal boron nitride and transition metal dichalcogenides, are normally limited by the known 3D bulk materials. The design and synthesis of entirely new 2D materials, particularly van der Waals (vdW) layered materials, would significantly expand the properties and functionalities of 2D materials. In 2020, a novel vdW layered material, MoSi2N4, was synthesized by passivating the surface of 2D non-layered molybdenum nitride with the addition of elemental silicon, which has since opened up a new vdW materials family with the general formula MA2Z4. To date, over a hundred MA2Z4 materials and their derivatives have been predicted, in addition to the synthesized MSi2N4 (M = Mo, W), encompassing metals, semiconductors, superconductors, topological insulators, ferroelectrics and ferromagnets, owing to the diversity of elements and structures in MA2Z4. Such materials exhibit a variety of exceptional electronic, optical, thermal, mechanical, ferroelectric and magnetic properties, and they are promising for applications in electronic and optoelectronic devices, electrocatalysis, photocatalysis and batteries. Over the past 4 years, the MoSi2N4 materials family has rapidly emerged as a key research frontier in materials science. In this Review, we summarize recent advances in the investigation of materials in the MoSi2N4 family, covering their crystal structure, synthesis methods, fundamental properties and potential applications, and provide an outlook on future research directions. The van der Waals MA2Z4 materials are a rapidly growing class of 2D materials with diverse electronic phases. This Review explores the structure, synthesis, properties and diverse applications of the emerging MA2Z4 family, highlighting their potential across electronics, catalysis and energy storage.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 12","pages":"907-928"},"PeriodicalIF":86.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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