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Stress Field Changes before the MS8.0 Wenchuan Earthquake 汶川8.0级地震前的应力场变化
Pub Date : 2021-09-02 DOI: 10.4236/ns.2021.139036
A. Niu, Jing Zhao, Y. Wei, Z. Yuan, Ping Ji
The apparent lack of pre-seismic crustal deformation preceding the 2008 Ms8.0 Wenchuan earthquake has been the subject of debate. In this study, tiltmeter data recorded close to the earthquake epicenter were analysed using spectrum and wavelet analysis. Changes in the stress field before the earthquake were analyzed based on the Benioff creep release and changes in regional Global Navigation Satellite System (GNSS) baselines. The characteris-tics of far- and near-field seismicity and deformation processes were investigated using rock fracture experiments. The results show that during pre-seismic strain energy accumu-lation, there was a synergy between stress field changes both proximal and distal to the ep-icenter; moreover, we identified a strong correlation between Benioff creep release and shortening of the LUZH-GUAN GNSS baseline. During the sub-instability stage, the de-formation characteristics of different structural sectors differed; faults near the epicenter were in a highly locked state, and the deformation rate and wave spectra of main period waves obviously decreased. This reflects fixed point deformation driven by deep stress. These results are of great significance for understanding geophysical field observations, for clarifying pre-seismic deformation and for earthquake prediction.
2008年汶川8.0级地震发生前,地壳明显没有发生变形,这一直是争论的主题。在本研究中,利用频谱和小波分析分析了靠近震中记录的倾斜仪数据。基于贝尼奥夫蠕变释放和区域GNSS基线的变化,分析了地震前应力场的变化。利用岩石断裂实验研究了远、近场地震活动特征和变形过程。结果表明:在震前应变能积累过程中,震源中心近端和远端应力场变化存在协同作用;此外,我们发现贝尼奥夫蠕变释放与LUZH-GUAN GNSS基线缩短之间存在很强的相关性。在亚失稳阶段,不同构造段的变形特征不同;震中附近断层处于高度锁定状态,主周期波的变形速率和波谱明显减小。这反映了深部应力驱动的定点变形。这些结果对认识地球物理野外观测、阐明震前形变和地震预报具有重要意义。
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引用次数: 1
Investigation of the Antimicrobial Activity and in Vivo Cytotoxicity of Diospyros malabarica (Desr.) Kostel. Fruit Extracts malabarica Diospyros的抑菌活性及体内细胞毒性研究Kostel。果提取物
Pub Date : 2021-08-02 DOI: 10.4236/ns.2021.138026
Razib Datta Shubhra, S. A. Polash, Monir Hossain, Amir Hamza, M. Tushar, Tanushree Saha, Md. Ashraful Hasan, M. Sikder, N. Alam, Zinia Islam, Md. Sharif Hossain, S. Sarker
Mankind is facing an unprecedented threat of existence due to the antibiotic resistance developed by bacteria. The unripe fruits of Diospyros malabarica (Desr.) Kostel. (family: Ebenaceae) can be considered as one of the natural sources to tackle this issue. The present study is designed to assess the antimicrobial activity of D. malabarica seed and flesh ex-tracts. Herein, D. malabarica extracts were prepared using polar solvents (i.e., water and 70% ethanol) and their antimicrobial activity as well as in vivo toxicity was investigated. Their antibacterial activity was investigated against gram positive (Bacillus subtilis) and gram negative (Escherichia coli DH5α, and Salmonella typhi) bacteria at different time points. All the extracts showed the highest antibacterial activity after 2 hours of incubation. The aqueous seed extract showed the maximum zone of inhibition (i.e., ~13 mm) against Bacillus subtilis with a minimum inhibitory concentration (MIC) value of 2 μg/μl. The an-tibacterial propensity was also confirmed through trypan blue dye exclusion assay, CellToxTM Green assay, and lipid peroxidation (LPO) assay. On the other hand, the etha-nolic seed extract demonstrated higher antifungal activity through inhibition of mycelial growth. All the extracts showed excellent hemocompatibility against both human and rat red blood cells (RBCs). They also did not show any toxicity to rat liver and kidneys. Taken together, this study demonstrates that the aqueous and ethanolic extracts of D. malabarica seed and flesh could be an effective source of natural antimicrobial agents with no cytotox-ic activity.
由于细菌产生的抗生素耐药性,人类正面临着前所未有的生存威胁。未成熟的果(属)Kostel。(科:Ebenaceae)可以被认为是解决这个问题的天然来源之一。本研究旨在评价马拉巴利菌种子和果肉提取物的抑菌活性。本文采用极性溶剂(水和70%乙醇)制备了马拉巴利木提取物,并对其抑菌活性和体内毒性进行了研究。在不同时间点对革兰氏阳性菌(枯草芽孢杆菌)和革兰氏阴性菌(大肠杆菌DH5α和伤寒沙门菌)的抑菌活性进行了研究。所有提取物在孵育2 h后抑菌活性最高。水提物对枯草芽孢杆菌的最大抑制区为~13 mm,最小抑制浓度(MIC)为2 μg/μl。通过台盼蓝染料排除试验、CellToxTM Green试验和脂质过氧化(LPO)试验也证实了其抗菌倾向。另一方面,乙醇-酚种子提取物通过抑制菌丝生长表现出较高的抗真菌活性。所有提取物对人和大鼠红细胞均具有良好的血液相容性。它们对大鼠的肝脏和肾脏也没有任何毒性。综上所述,本研究表明,马拉巴利木种子和果肉的水提液和醇提液可能是天然抗菌药物的有效来源,且不具有细胞毒活性。
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引用次数: 1
Prediction of Protein Expression and Growth Rates by Supervised Machine Learning 用监督机器学习预测蛋白质表达和生长速度
Pub Date : 2021-08-02 DOI: 10.4236/ns.2021.138025
Simiao Zhao
The DNA sequences of an organism play an important influence on its transcription and translation process, thus affecting its protein production and growth rate. Due to the com-plexity of DNA, it was extremely difficult to predict the macroscopic characteristics of or-ganisms. However, with the rapid development of machine learning in recent years, it be-comes possible to use powerful machine learning algorithms to process and analyze biolog-ical data. Based on the synthetic DNA sequences of a specific microbe, E. coli, I designed a process to predict its protein production and growth rate. By observing the properties of a data set constructed by previous work, I chose to use supervised learning regressors with encoded DNA sequences as input features to perform the predictions. After comparing different encoders and algorithms, I selected three encoders to encode the DNA sequences as inputs and trained seven different regressors to predict the outputs. The hy-per-parameters are optimized for three regressors which have the best potential prediction performance. Finally, I successfully predicted the protein production and growth rates, with the best R2 score 0.55 and 0.77, respectively, by using encoders to catch the potential fea-tures from the DNA sequences.
生物体的DNA序列对其转录和翻译过程有重要影响,从而影响其蛋白质的产生和生长速度。由于DNA的复杂性,预测生物的宏观特征是极其困难的。然而,随着近年来机器学习的快速发展,使用强大的机器学习算法来处理和分析生物数据成为可能。基于一种特定微生物——大肠杆菌的合成DNA序列,我设计了一个过程来预测它的蛋白质产量和生长速度。通过观察先前工作构建的数据集的属性,我选择使用带有编码DNA序列的监督学习回归器作为输入特征来执行预测。在比较了不同的编码器和算法后,我选择了三个编码器来编码DNA序列作为输入,并训练了七个不同的回归器来预测输出。对具有最佳预测潜力的三个回归量进行了超参数优化。最后,我利用编码器捕捉DNA序列的潜在特征,成功预测了蛋白质产量和生长率,R2得分最高,分别为0.55和0.77。
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引用次数: 1
New Long-Term Climate Oscillations 新的长期气候振荡
Pub Date : 2021-08-02 DOI: 10.4236/ns.2021.138028
J. Smulsky
The astronomical theory of climate change is based on the solution of differential equations describing Earth’s orbital and rotational motions. The equations are used to calculate the change in insolation over the Earth’s surface. As a result of the author’s solution of the orbital problem, the periods and amplitudes of Earth-orbit variations and their evolution have been refined. Unlike previous studies, the equations of Earth’s rotational motion are solved completely. The Earth’s rotational axis precesses relative to a direction different from the direction of the orbit’s axial precession, and oscillates with periods of half a month, half a year and 18.6 years. Also, its oscillations occur with irregular periods of several tens of thousands of years and more. All these motions lead to oscillations of the obliquity in the range of 14.7° to 32.1°, which prove to be 7 - 8 times larger than obtained by a previous theory. In the same proportion, the Earth’s insolation oscillations increase in amplitude, with insolation extremes occurring in other epochs than those in the previous theory. The amplitudes and the onset times of the extremes correlate with known paleoclimate changes. Thirteen insolation periods of paleoclimate variation over an interval of 200 thousand years are identified. From the insolation evolution calculated over a time interval of 1 million years, 6 climate gradations from very cold to very warm are identified.
气候变化的天文学理论是建立在描述地球轨道和自转运动的微分方程的解的基础上的。这些方程式被用来计算地球表面日晒量的变化。由于作者对轨道问题的解决,地球轨道变化的周期和幅度及其演变得到了改进。与以往的研究不同,地球自转的方程得到了完整的解。地球自转轴的进动方向与轨道的轴进动方向不同,周期分别为半个月、半年和18.6年。此外,它的振荡以几万年甚至更长时间的不规则周期发生。所有这些运动导致了在14.7°到32.1°范围内的倾角振荡,这证明了比以前的理论得到的大7 - 8倍。同样的比例,地球的日晒振荡振幅增加,极端日晒发生在其他时期,而不是以前的理论。极端事件的振幅和发生时间与已知的古气候变化有关。确定了20万年间古气候变化的13个日晒期。在100万年的时间间隔内计算日晒演变,确定了从极冷到极暖的6个气候等级。
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引用次数: 0
Siberian Fan Reliefs 西伯利亚扇区
Pub Date : 2021-08-02 DOI: 10.4236/ns.2021.138029
O. Gladysheva, A. Yastrebov
Unusual reliefs on the Earth’s surface were found in aerial photographs of Eastern Siberia in the late 20th century. These reliefs consist of several tens (up to hundreds) of stripes that have arisen as a result of the destruction of vegetation and the surface layer of the ground. Structures of stripes are extended, ranging in size from 6 km to ≥20 km, with a width of several kilometers. Every strip (scratch on the ground) is roughly estimated to be up to 50 m wide and ≥500 m long. The stripes start from one edge of the relief and stretch at inter-vals to the other, slightly diverging symmetrically from the central axis. It was determined that these reliefs are not associated with the movement of soil (avalanches, mudflows) or with the impact of air currents (hurricanes, storm, tornado). Geographically, these struc-tures of stripes are located within a circle with a radius of 770 km, described around the epicenter of the Tunguska catastrophe.
在20世纪末东西伯利亚的航拍照片中发现了地球表面不同寻常的浮雕。这些浮雕由几十条(最多数百条)条纹组成,这些条纹是由于植被和地面表层的破坏而形成的。条纹结构扩展,大小从6公里到≥20公里不等,宽度达数公里。每条(地面划痕)粗估宽度不超过50m,长度≥500m。条纹从浮雕的一个边缘开始,以间隔延伸到另一个边缘,从中轴线对称地略微发散。经确定,这些地形起伏与土壤运动(雪崩、泥石流)或气流影响(飓风、风暴、龙卷风)无关。从地理上看,这些条纹结构位于通古斯大灾难震中周围半径770公里的圆圈内。
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引用次数: 3
Anemometer Modified II 改进型风速计
Pub Date : 2021-08-02 DOI: 10.4236/ns.2021.138027
K. Kenyon
A commercial anemometer was modified by replacing the four cups with four identical two-dimensional blades, each with a circular arc side and a flat side. The flat sides are fixed to four arms radiating from a pivot so that they are parallel to the wind direction. The rounded sides all point in the same direction around a circle. When the wind blows, there is a lift force on the rounded side of each blade and they unite in causing rotation about the pivot with the curved sides leading. The more blades the faster the rotation is a prediction.
一个商业风速计被改进,用四个相同的二维叶片代替了四个杯子,每个叶片都有一个圆弧边和一个平边。平面侧面固定在从枢轴向外辐射的四个臂上,使它们与风向平行。所有的圆边都围绕一个圆指向同一个方向。当风吹起时,每个叶片的圆形侧面都有一个升力,它们结合在一起,以弯曲的侧面为主导,围绕枢轴旋转。叶片越多,旋转速度越快是一个预测。
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引用次数: 0
Potential Power of the Pyramidal Structure IV: Discovery of Entanglement Due to Pyramid Effects 金字塔结构的势能IV:由于金字塔效应的纠缠的发现
Pub Date : 2021-07-08 DOI: 10.4236/ns.2021.137022
O. Takagi, Masamichi Sakamoto, Kimiko Kawano, Mikio Yamamoto
Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify pyramid effects by the PS into the following two types: (i) the pyramid effects due to the potential power of the PS and (ii) the pyramid effects due to the influence of the test subject meditating inside the PS. We have been using edible cucumber sections as the biosensors. The pyramid effect existence was clarified by measuring and analyzing the concentration of volatile components released from the biosensors. The biosensors were arranged as a pair: one member of the pair was placed at the PS apex and the other was placed at the calibration control point 8.0 m away from the PS. In this paper, we report a new discovery regarding the type (i) pyramid effects. We discovered a phenomenon considered to be entanglement between the biosensor pairs detecting the pyramid effects. In other words, the biosensors at the PS apex, which were affected by the potential power of the PS, affected the biosensors at the calibration control point. We also confirmed that the effects on the biosensors placed at the calibration control point were not due to the potential power of the PS. Furthermore, we showed that the magnitude of the effect of entanglement changed with the seasons. We expect that our research results will be widely accepted in the future and will become the foundation for a new research field in science, with a wide range of applications.
自2007年10月以来,我们一直在对金字塔结构(PS)无法解释的“力量”进行严格的科学研究。从我们目前的研究结果来看,我们可以将PS产生的金字塔效应分为以下两种类型:(i)由于PS的潜在力量而产生的金字塔效应;(ii)由于被试者在PS内冥想的影响而产生的金字塔效应。我们一直使用可食用的黄瓜切片作为生物传感器。通过测量和分析生物传感器释放的挥发性成分浓度,证实了金字塔效应的存在。生物传感器被布置成一对:一对中的一个成员放置在PS顶点,另一个放置在距离PS 8.0 m的校准控制点。在本文中,我们报告了关于(i)型金字塔效应的新发现。我们发现了一种现象,被认为是生物传感器对之间的纠缠检测金字塔效应。也就是说,PS顶点的生物传感器受到PS电位的影响,从而影响校准控制点的生物传感器。我们还证实了对放置在校准控制点的生物传感器的影响不是由于PS的潜在功率。此外,我们还表明纠缠的影响程度随季节而变化。我们期望我们的研究成果在未来能够被广泛接受,并成为一个新的科学研究领域的基础,具有广泛的应用前景。
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引用次数: 5
When an Incompressible Ocean Impacts a Compressible Continent 当不可压缩的海洋撞击可压缩的大陆
Pub Date : 2021-07-08 DOI: 10.4236/ns.2021.137021
K. Kenyon
The horizontal force on a continent, at the land/ocean boundary, is calculated according to the concept of reflected tide waves, in which there is a time rate of change (reversal) of the linear momentum brought in by the tide to the continent. From the text books, the Stokes drift for surface gravity waves propagating in arbitrary constant mean depth, which is directly related to the linear momentum of the wave, is adapted to the tide wave by using the approximation that the wavelength of the tide is very much larger than the vertical length of the water column. This horizontal force is a maximum at full and new moon when the tide amplitude is greatest. Evidence is cited for the correlation of earthquakes at full moons. The tendency of the reflected tide force on the continents is to cause compression of the solid material in the horizontal direction and it is suggested that this possibly could trigger earthquakes occasionally.
陆地/海洋边界上的水平力是根据反射潮汐波的概念计算的,其中潮汐给大陆带来的线性动量有一个时间变化率(反转)。从教科书上看,在任意恒定平均深度传播的表面重力波的Stokes漂移与波的线性动量直接相关,它是利用潮汐的波长比水柱的垂直长度大得多的近似来适应潮汐波的。这种水平力在满月和新月时最大,此时潮汐振幅最大。有证据表明满月时地震的相关性。大陆上反射的潮汐力倾向于造成固体物质在水平方向上的压缩,这可能会引起偶尔的地震。
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引用次数: 0
A Petrophysical Approach to Evaluation from Measured While Drilling Gamma Ray, Case Study in the Powder River and Delaware Basins 随钻测量伽马射线的岩石物理评价方法,以Powder River和Delaware盆地为例
Pub Date : 2021-07-08 DOI: 10.4236/ns.2021.137024
S. Perry
One of the most common subsurface data sets that is easily accessible and often underutilized is the acquired measuring while drilling (MWD) gamma ray (GR-GAPI) log. Data is acquired from a given gamma ray tool positioned within the drill string and pulsed up to the surface through the mud column in the wellbore. Typical use of the data is for subsurface geologists, drillers and others to correlate the data to known stratigraphic signatures and steer wells through horizontal target zones. Through that correlation, an association to the geologic stratigraphic column can be made and the team of subsurface scientists adjusts where, how fast, and why they choose to continue drilling. The technique of correlation applies to both the conventional and unconventional application. In the unconventional application, the data is also typically acquired along the length of the horizontal wellbore. From a petrophysical standpoint, just acquiring a gamma ray can limit the amount of information and ability to fully evaluate the properties along the length of the well. In this study, we share and demonstrate how to utilize the MWD GR for petrophysical evaluation beyond just a volume of shale or volume of clay interpretation. The workflow will allow full integration of a comprehensive petrophysical evaluation that can then be utilized to support all subsurface understandings and modelling efforts.
最常见的地下数据集之一是随钻测量(MWD)伽马射线(GR-GAPI)测井,该数据集易于获取,但往往未得到充分利用。数据从位于钻柱内的伽马射线工具获取,并通过井筒中的泥浆柱脉冲到达地面。这些数据的典型用途是让地下地质学家、钻井人员和其他人员将数据与已知的地层特征联系起来,并引导井穿过水平目标带。通过这种相关性,可以与地质地层柱建立联系,地下科学家团队可以调整他们选择继续钻探的地点、速度和原因。相关技术适用于常规和非常规应用。在非常规应用中,通常沿着水平井筒的长度获取数据。从岩石物理学的角度来看,仅仅获取伽马射线可能会限制信息的数量和对井长进行全面评估的能力。在这项研究中,我们分享并演示了如何利用随钻随钻GR进行岩石物理评价,而不仅仅是页岩或粘土体积的解释。该工作流程将允许全面整合岩石物理评估,然后可用于支持所有地下理解和建模工作。
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引用次数: 0
Space and Human Consciousness: The Great Whisper 空间与人类意识:伟大的低语
Pub Date : 2021-07-08 DOI: 10.4236/ns.2021.137020
A. Alabdulgader
Human Consciousness is one of most elusive issues in the scientific history. Its nature created major historical debate started thousands of years ago and still ongoing. Despite the explosive developments in the last century to explore its nature, the knowledge about it is still deficient. The important advances in the twentieth and 21st centuries in understanding cerebral cortex dynamics fortified by the dominant materialistic approach of the era dictated its impact on consciousness science, which is perceived as sole human brain function. This original review is a call for holistic perception of human consciousness incorporating the ancient wisdom of the human civilizations with the massive current era advances in different disciplines of applied sciences. The description of Rene Descartes in the 17th century of the Cartesian dualism is timely to revisit with new holistic perspective, in view of the major advances of our understanding of heart brain communications, astrophysical resonances with human heart ascending afferents to central nervous system, and signaling between humans and the space. Universal vibrations, frequencies and resonances as perceived by Nikola Tesla constitute the core of our new conceptual and experimental perspective on human consciousness. Neural and psychological correlates of human consciousness which dominate the consciousness research nowadays should undergo revolutionary conceptual understanding to perceive consciousness as a massive universal event expanding from human genes to galaxies. In the next discussion, we are going to navigate in the nature and fate of human consciousness with new innovative universal perspective based on heart rate variability of human heart and its cosmic resonances as represented by Schumann Resonances, Solar Wind Indices and Galactic Cosmic Rays. The interpretation of our existential secrets and biology without the space around us is a major gap in our scientific perception of life. The delicate orchestration between human heart and the space frequencies create the great whisper which in our perspective, encodes the secrets of human consciousness.
人类意识是科学史上最难以捉摸的问题之一。它的性质引发了数千年前就开始的重大历史争论,至今仍在继续。尽管上个世纪在探索其本质方面有了爆炸性的发展,但对其的认识仍然不足。在20世纪和21世纪,在理解大脑皮层动力学方面取得了重要进展,这一进展得到了当时占主导地位的唯物主义方法的加强,决定了它对意识科学的影响,意识科学被认为是人类大脑的唯一功能。这篇原创性的评论呼吁将人类文明的古老智慧与当今时代应用科学各学科的巨大进步结合起来,对人类意识进行整体感知。考虑到我们对心脑通信、与人类心脏上升传入中枢神经系统的天体物理共振以及人与空间之间的信号的理解取得的重大进展,17世纪笛卡尔的笛卡尔二元论的描述是及时的,以新的整体视角来重新审视。尼古拉·特斯拉所感知到的宇宙振动、频率和共振构成了我们对人类意识的新概念和实验视角的核心。目前主导意识研究的神经和心理相关因素应该经过革命性的概念理解,将意识视为一个从人类基因扩展到星系的巨大的普遍事件。在接下来的讨论中,我们将以人类心脏的心率变异性及其以舒曼共振、太阳风指数和银河宇宙射线为代表的宇宙共振为基础,以创新的普遍视角来导航人类意识的本质和命运。在没有我们周围空间的情况下,对我们存在的秘密和生物学的解释是我们对生命的科学感知的一个主要空白。人类心脏和空间频率之间的微妙的协调创造了伟大的低语,在我们看来,编码了人类意识的秘密。
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引用次数: 4
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