Pub Date : 2025-04-17DOI: 10.1016/j.neures.2025.04.002
Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.
代谢综合征（MetS）和2型糖尿病（T2D）与周围神经的炎症和巨噬细胞积聚有关，这增加了发生周围神经病变（PN）的风险。我们之前研究了T2D动物（瘦素缺乏的ob/ob小鼠，瘦素受体缺乏的db/db）周围神经中的巨噬细胞浸润与PN相关，而met动物（Wistar Ottawa Karlsburg W (RT1u) WOKW大鼠）的这一过程不会导致神经性改变。本研究提供的其他数据表明，抗炎标志物IL-10 mRNA表达增加与自噬预防神经病变之间存在关联。
{"title":"Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus","authors":"Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka","doi":"10.1016/j.neures.2025.04.002","DOIUrl":"10.1016/j.neures.2025.04.002","url":null,"abstract":"<div><div>Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient <em>ob/ob</em> mice, leptin receptor-deficient <em>db/db</em>) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (<em>RT1u</em>) <em>WOKW</em> rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104899"},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-15DOI: 10.1016/j.neures.2025.04.001
Jianhua Liu
This study aims to investigate the neural correlates of brand longevity on consumers’ purchase intention by applying the event-related potentials (ERP) method. Behaviorally, in contrast to the short longevity condition, participants in the long longevity condition showed a high purchase rate and a shorter reaction time (RT). In addition, at the neural level, the long longevity condition elicited a decreased N400 and an increased LPP compared to the short longevity condition. This study demonstrated that brand longevity has a positive impact on consumers’ purchase intention. The results of this study extend research on brand heritage.
{"title":"The impact of brand longevity on consumers’ purchase intention: An ERP study","authors":"Jianhua Liu","doi":"10.1016/j.neures.2025.04.001","DOIUrl":"10.1016/j.neures.2025.04.001","url":null,"abstract":"<div><div>This study aims to investigate the neural correlates of brand longevity on consumers’ purchase intention by applying the event-related potentials (ERP) method. Behaviorally, in contrast to the short longevity condition, participants in the long longevity condition showed a high purchase rate and a shorter reaction time (RT). In addition, at the neural level, the long longevity condition elicited a decreased N400 and an increased LPP compared to the short longevity condition. This study demonstrated that brand longevity has a positive impact on consumers’ purchase intention. The results of this study extend research on brand heritage.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104898"},"PeriodicalIF":2.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-04DOI: 10.1016/j.neures.2025.03.009
Soomin C. Song , Robert C. Froemke
Most offspring are born helpless, requiring intense caregiving from parents especially during the first few days of neonatal life. For many species, infant cries are a primary signal used by parents to provide caregiving. Previously we and others documented how maternal left auditory cortex rapidly becomes sensitized to pup calls over hours of parental experience, enabled by oxytocin. The speed and robustness of this maternal plasticity suggests cortical pre-tuning or initial bias for pup call stimulus features. Here we examine the circuit basis of left-lateralized tuning to vocalization features with whole-cell recordings in brain slices. We found that layer 2/3 pyramidal cells of female left auditory cortex show selective suppression of inhibitory inputs with repeated stimulation at the fundamental pup call rate (inter-stimulus interval ∼150 msec) in pup-naïve females and expanded with maternal experience. However, optogenetic stimulation of cortical inhibitory cells showed that inputs from somatostatin-positive and oxytocin-receptor-expressing interneurons were less suppressed at these rates. This suggested that disynaptic inhibition rather than monosynaptic depression was a major mechanism underlying pre-tuning of cortical excitatory neurons, confirmed with simulations. Thus cortical interneuron specializations can augment neuroplasticity mechanisms to ensure fast appropriate caregiving in response to infant cries.
{"title":"Lateralized local circuit tuning in female mouse auditory cortex","authors":"Soomin C. Song , Robert C. Froemke","doi":"10.1016/j.neures.2025.03.009","DOIUrl":"10.1016/j.neures.2025.03.009","url":null,"abstract":"<div><div>Most offspring are born helpless, requiring intense caregiving from parents especially during the first few days of neonatal life. For many species, infant cries are a primary signal used by parents to provide caregiving. Previously we and others documented how maternal left auditory cortex rapidly becomes sensitized to pup calls over hours of parental experience, enabled by oxytocin. The speed and robustness of this maternal plasticity suggests cortical pre-tuning or initial bias for pup call stimulus features. Here we examine the circuit basis of left-lateralized tuning to vocalization features with whole-cell recordings in brain slices. We found that layer 2/3 pyramidal cells of female left auditory cortex show selective suppression of inhibitory inputs with repeated stimulation at the fundamental pup call rate (inter-stimulus interval ∼150 msec) in pup-naïve females and expanded with maternal experience. However, optogenetic stimulation of cortical inhibitory cells showed that inputs from somatostatin-positive and oxytocin-receptor-expressing interneurons were less suppressed at these rates. This suggested that disynaptic inhibition rather than monosynaptic depression was a major mechanism underlying pre-tuning of cortical excitatory neurons, confirmed with simulations. Thus cortical interneuron specializations can augment neuroplasticity mechanisms to ensure fast appropriate caregiving in response to infant cries.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104897"},"PeriodicalIF":2.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-29DOI: 10.1016/j.neures.2025.03.006
Yoshinori Hayakawa , Haruka Ozaki
Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the single-cell level, providing unprecedented insights into cellular heterogeneity, rare cell populations, and dynamic cellular processes. In neuroscience, scRNA-seq has enabled the identification of diverse brain cell types, elucidation of developmental pathways, and discovery of mechanisms underlying neurological diseases. This tutorial provides a practical guide to scRNA-seq data analysis in neuroscience, focusing on the essential workflows and theoretical foundations. Key steps covered include quality control, data preprocessing, integration, cell clustering, and differential expression analysis. Using the Seurat R package, the tutorial demonstrates a comparative analysis approach for identifying differentially expressed genes between conditions, emphasizing the biological interpretation of results. By addressing the unique challenges of scRNA-seq data and illustrating methods for robust analysis, this work aims to enhance the reliability and reproducibility of scRNA-seq studies in neuroscience, supporting the exploration of cellular mechanisms and advancing research into brain function and disease.
{"title":"A practical guide for single-cell transcriptome data analysis in neuroscience","authors":"Yoshinori Hayakawa , Haruka Ozaki","doi":"10.1016/j.neures.2025.03.006","DOIUrl":"10.1016/j.neures.2025.03.006","url":null,"abstract":"<div><div>Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the single-cell level, providing unprecedented insights into cellular heterogeneity, rare cell populations, and dynamic cellular processes. In neuroscience, scRNA-seq has enabled the identification of diverse brain cell types, elucidation of developmental pathways, and discovery of mechanisms underlying neurological diseases. This tutorial provides a practical guide to scRNA-seq data analysis in neuroscience, focusing on the essential workflows and theoretical foundations. Key steps covered include quality control, data preprocessing, integration, cell clustering, and differential expression analysis. Using the Seurat R package, the tutorial demonstrates a comparative analysis approach for identifying differentially expressed genes between conditions, emphasizing the biological interpretation of results. By addressing the unique challenges of scRNA-seq data and illustrating methods for robust analysis, this work aims to enhance the reliability and reproducibility of scRNA-seq studies in neuroscience, supporting the exploration of cellular mechanisms and advancing research into brain function and disease.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"214 ","pages":"Pages 9-15"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elicit event-related synchronization of the beta rhythm in contralateral sensorimotor cortex, termed beta rebound, and a strong correlation was reported between proprioception-induced rebound strength and clinical recovery in stroke patients. We investigated the effects of tACS matched to the dominant beta frequency on the strength of proprioception-induced beta rebound.We recorded the beta rebound from 14 healthy young adults in response to passive index finger movement by electroencephalography to determine individual peak beta frequency. Electroencephalograms (EEG) were recorded during passive movements before and after active or sham tACS. We recorded beta rebound of all participants to determine their individual peak frequency of beta rebound prior to this experiment. Active tACS at individually matched frequencies increased beta rebound strength during subsequent passive movement compared to sham tACS in the majority of participants, while the remaining participants demonstrated no significant change or a decrease. These findings on healthy participants provide an essential foundation for further studies on the effects of beta frequency-matched tACS for stroke patient rehabilitation.
{"title":"Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency","authors":"Mayu Akaiwa , Ryo Kurokawa , Yuya Matsuda , Yasushi Sugawara , Rin Kosuge , Hidekazu Saito , Eriko Shibata , Takeshi Sasaki , Kazuhiro Sugawara","doi":"10.1016/j.neures.2025.03.008","DOIUrl":"10.1016/j.neures.2025.03.008","url":null,"abstract":"<div><div>Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elicit event-related synchronization of the beta rhythm in contralateral sensorimotor cortex, termed beta rebound, and a strong correlation was reported between proprioception-induced rebound strength and clinical recovery in stroke patients. We investigated the effects of tACS matched to the dominant beta frequency on the strength of proprioception-induced beta rebound.We recorded the beta rebound from 14 healthy young adults in response to passive index finger movement by electroencephalography to determine individual peak beta frequency. Electroencephalograms (EEG) were recorded during passive movements before and after active or sham tACS. We recorded beta rebound of all participants to determine their individual peak frequency of beta rebound prior to this experiment. Active tACS at individually matched frequencies increased beta rebound strength during subsequent passive movement compared to sham tACS in the majority of participants, while the remaining participants demonstrated no significant change or a decrease. These findings on healthy participants provide an essential foundation for further studies on the effects of beta frequency-matched tACS for stroke patient rehabilitation.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104896"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-22DOI: 10.1016/j.neures.2025.03.005
Yuta Maetani , Takashi Kurashige , Yui Tada , Kodai Kume , Tomoaki Watanabe , Yusuke Sotomaru , Koji Yamanaka , Hirofumi Maruyama , Hideshi Kawakami
Optineurin is a causative gene of amyotrophic lateral sclerosis (ALS) and has many roles in processes such as autophagy and inflammation. However, it is unclear how optineurin causes ALS. Optineurin knock-out (Optn-KO) mice, which have been generated by several researchers, exhibit motor neuron degeneration and TDP-43 aggregates, but no motor deficits. Motor dysfunction in ALS model mice is associated with TDP-43 in the spinal cord. We bred Optn-KO mice with TDP-43 overexpression transgenic mice and evaluated whether increased TDP-43 protein causes motor deficits and whether Optn-KO affects TDP-43 protein level. Optn-KO mice had spinal TDP-43 protein levels and motor function comparable to wild-type mice, and TDP-43-transgenic (TDP-43-tg) mice resulted in motor dysfunction and early death. However, double-mutant TDP-43-tg / Optn-KO mice had lower TDP-43 protein levels than TDP-43-tg mice at 18 months age, and showed inhibition of the TBK1-optinerurin autophagic pathway with aging. Furthermore, Optn-KO caused TDP-43-positive cytoplasmic aggregates. TDP-43 overexpression by itself induced spinal microgliosis, but Optn-KO suppressed that microgliosis. Finally, we showed that Optn-KO mice could not exhibit behavioral dysfunction because TDP-43 protein levels were not elevated despite autophagy inhibition. Thus, downregulation of Optn may suppress TDP-43 toxicity by regulating its abundance through aggregate formation.
{"title":"Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression","authors":"Yuta Maetani , Takashi Kurashige , Yui Tada , Kodai Kume , Tomoaki Watanabe , Yusuke Sotomaru , Koji Yamanaka , Hirofumi Maruyama , Hideshi Kawakami","doi":"10.1016/j.neures.2025.03.005","DOIUrl":"10.1016/j.neures.2025.03.005","url":null,"abstract":"<div><div><em>Optineurin</em> is a causative gene of amyotrophic lateral sclerosis (ALS) and has many roles in processes such as autophagy and inflammation. However, it is unclear how optineurin causes ALS. <em>Optineurin</em> knock-out (<em>Optn</em>-KO) mice, which have been generated by several researchers, exhibit motor neuron degeneration and TDP-43 aggregates, but no motor deficits. Motor dysfunction in ALS model mice is associated with TDP-43 in the spinal cord. We bred <em>Optn</em>-KO mice with TDP-43 overexpression transgenic mice and evaluated whether increased TDP-43 protein causes motor deficits and whether <em>Optn</em>-KO affects TDP-43 protein level. <em>Optn</em>-KO mice had spinal TDP-43 protein levels and motor function comparable to wild-type mice, and TDP-43-transgenic (TDP-43-tg) mice resulted in motor dysfunction and early death. However, double-mutant TDP-43-tg / <em>Optn</em>-KO mice had lower TDP-43 protein levels than TDP-43-tg mice at 18 months age, and showed inhibition of the TBK1-optinerurin autophagic pathway with aging. Furthermore, <em>Optn</em>-KO caused TDP-43-positive cytoplasmic aggregates. TDP-43 overexpression by itself induced spinal microgliosis, but <em>Optn</em>-KO suppressed that microgliosis. Finally, we showed that <em>Optn</em>-KO mice could not exhibit behavioral dysfunction because TDP-43 protein levels were not elevated despite autophagy inhibition. Thus, downregulation of <em>Optn</em> may suppress TDP-43 toxicity by regulating its abundance through aggregate formation.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104893"},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Many types of voluntary movement depend on appropriate postural adjustments. In most situations, such postural adjustments are influenced by learning and are therefore subject to prediction strategies developed through learning. To address how these prediction strategies affect early postural adjustments (EPAs) that occur several hundred milliseconds before movement, we trained two cats in a reaching task where the location of the target was predictable through learning. At the beginning of each trial, the cat stood still with each paw on a force plate for several hundred milliseconds. A target then appeared on either side of a horizontal touch panel, prompting the cat to lift a forepaw. A food reward followed upon holding the target with the forepaw. Target location was alternated every three rewarded trials: one SWITCH followed by two STAY trials. In both cats, EPAs prior to target onset in STAY trials were significantly dependent on the predetermined target location, indicating that they anticipated the target location as a part of their strategy. In SWITCH trials, EPAs aligned with the subsequent STAY trials in both switch directions for one cat, but only in one direction for the other, suggesting that they developed different strategies to handle target location switches.
{"title":"Early postural adjustments in cats during a reaching task reflect strategies to predict the forthcoming target location","authors":"Toshi Nakajima , Mirai Takahashi , Kaoru Takakusaki","doi":"10.1016/j.neures.2025.03.003","DOIUrl":"10.1016/j.neures.2025.03.003","url":null,"abstract":"<div><div>Many types of voluntary movement depend on appropriate postural adjustments. In most situations, such postural adjustments are influenced by learning and are therefore subject to prediction strategies developed through learning. To address how these prediction strategies affect early postural adjustments (EPAs) that occur several hundred milliseconds before movement, we trained two cats in a reaching task where the location of the target was predictable through learning. At the beginning of each trial, the cat stood still with each paw on a force plate for several hundred milliseconds. A target then appeared on either side of a horizontal touch panel, prompting the cat to lift a forepaw. A food reward followed upon holding the target with the forepaw. Target location was alternated every three rewarded trials: one SWITCH followed by two STAY trials. In both cats, EPAs prior to target onset in STAY trials were significantly dependent on the predetermined target location, indicating that they anticipated the target location as a part of their strategy. In SWITCH trials, EPAs aligned with the subsequent STAY trials in both switch directions for one cat, but only in one direction for the other, suggesting that they developed different strategies to handle target location switches.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104891"},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.neures.2025.03.002
Alessandro Carollo , Lucrezia Torre , Marc H. Bornstein , Gianluca Esposito
Studies of the parental brain have garnered significant attention, revealing neurobiological and psychological changes associated with caregiving. Here, we provide a comprehensive, data-driven overview of the scientific literature on the parental brain, analyzing a large dataset to map the field’s knowledge structure. Our objectives include identifying influential authors, contributing countries, publication sources, and commonly used keywords as well as highlighting the most impactful documents and primary thematic areas of research. We analyzed 656 documents (and their 39,302 cited references) from Scopus using CiteSpace software for document co-citation analysis. Our analysis identified 17 key documents, of which the most influential focused on neural correlates of maternal and romantic love and maternal brain responses to infant cues in relation to attachment style. Our analysis additionally identified 10 major thematic domains in the parental brain literature. Qualitative analysis of research clusters revealed a trajectory in the study of the parental brain, progressing from foundational studies on dendritic spine density and maternal memory to the exploration of shared mammalian and human-specific brain networks underlying parental behaviors. Our study points to a growing interest in understanding neurobiological changes in fathers, with parental involvement and exposure to infant cues as moderating factors. The parental brain is a plastic, dynamic network, with bio-behavioral synchrony playing a central role as an interpersonal mechanism that enhances specificity of attachments.
{"title":"The parental brain: Anatomization of 75 years of neuroscience 1951–2024","authors":"Alessandro Carollo , Lucrezia Torre , Marc H. Bornstein , Gianluca Esposito","doi":"10.1016/j.neures.2025.03.002","DOIUrl":"10.1016/j.neures.2025.03.002","url":null,"abstract":"<div><div>Studies of the parental brain have garnered significant attention, revealing neurobiological and psychological changes associated with caregiving. Here, we provide a comprehensive, data-driven overview of the scientific literature on the parental brain, analyzing a large dataset to map the field’s knowledge structure. Our objectives include identifying influential authors, contributing countries, publication sources, and commonly used keywords as well as highlighting the most impactful documents and primary thematic areas of research. We analyzed 656 documents (and their 39,302 cited references) from Scopus using CiteSpace software for document co-citation analysis. Our analysis identified 17 key documents, of which the most influential focused on neural correlates of maternal and romantic love and maternal brain responses to infant cues in relation to attachment style. Our analysis additionally identified 10 major thematic domains in the parental brain literature. Qualitative analysis of research clusters revealed a trajectory in the study of the parental brain, progressing from foundational studies on dendritic spine density and maternal memory to the exploration of shared mammalian and human-specific brain networks underlying parental behaviors. Our study points to a growing interest in understanding neurobiological changes in fathers, with parental involvement and exposure to infant cues as moderating factors. The parental brain is a plastic, dynamic network, with bio-behavioral synchrony playing a central role as an interpersonal mechanism that enhances specificity of attachments.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104890"},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.neures.2025.03.004
Yasuhiro Go
In neuroscience research, the primary goal is to understand the complex morphological and anatomical structures of the brain and their physiological and behavioral functional relationships or to understand the causality of diseases that manifest as dysfunction of the brain, and various technologies have been developed to achieve this goal. These include imaging techniques such as magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and positron emission tomography (PET), which noninvasively visualize brain structure and activity; electrophysiological techniques that measure intracellular potentials and currents and analyze cell electrical properties to understand brain activity; techniques to explore how gene expression affects brain function; genetic methods such as gene knockout/knock-in to study how brain cells function; and computational neuroscience methods such as mathematical modeling and simulation to understand the principles of how brain networks operate. Among these, recent advances, particularly the development of 'single-cell omics analysis,' have led to a paradigm shift in neuroscience research. This technique allows the comprehensive study of the unique genetic and molecular characteristics of individual brain cells at the single-cell level. In this paper, I review the application of single-cell omics analysis, which has advanced dramatically in recent years, to various neuroscience problems, mainly how it contributes to the structure and function of neural circuits, a modality unique to the cranial nervous system.
{"title":"Neural circuit research using molecular barcode technology","authors":"Yasuhiro Go","doi":"10.1016/j.neures.2025.03.004","DOIUrl":"10.1016/j.neures.2025.03.004","url":null,"abstract":"<div><div>In neuroscience research, the primary goal is to understand the complex morphological and anatomical structures of the brain and their physiological and behavioral functional relationships or to understand the causality of diseases that manifest as dysfunction of the brain, and various technologies have been developed to achieve this goal. These include imaging techniques such as magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and positron emission tomography (PET), which noninvasively visualize brain structure and activity; electrophysiological techniques that measure intracellular potentials and currents and analyze cell electrical properties to understand brain activity; techniques to explore how gene expression affects brain function; genetic methods such as gene knockout/knock-in to study how brain cells function; and computational neuroscience methods such as mathematical modeling and simulation to understand the principles of how brain networks operate. Among these, recent advances, particularly the development of 'single-cell omics analysis,' have led to a paradigm shift in neuroscience research. This technique allows the comprehensive study of the unique genetic and molecular characteristics of individual brain cells at the single-cell level. In this paper, I review the application of single-cell omics analysis, which has advanced dramatically in recent years, to various neuroscience problems, mainly how it contributes to the structure and function of neural circuits, a modality unique to the cranial nervous system.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"214 ","pages":"Pages 3-8"},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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