Nutrition Research最新文献

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Spirulina liquid extract regulates gene expression related to glucose and lipid metabolisms of soleus muscle during exercise training in young male Wistar rats fed a high-fat diet 螺旋藻液体提取物在高脂饮食喂养的年轻雄性Wistar大鼠运动训练中调节比目鱼肌糖脂代谢相关基因表达

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-11-01 Epub Date: 2025-09-15 DOI: 10.1016/j.nutres.2025.09.006

Jordi Vignaud , Céline Loiseau , Martine Côme , Josiane Hérault , Claire Mayer , Olivier Lépine , Lionel Ulmann

Metabolic disorders induced by high-fat diets (HFD) contribute to obesity, diabetes, and cardiovascular diseases. While Spirulina liquid extract (SLE) has shown promise in improving lipid accumulation and insulin resistance, in vivo evidence remains limited, particularly in combination with exercise. Muscle activity is a key regulator of metabolism, but the potential combined effect of SLE and physical training under HFD conditions has not been established. In this study, young male rats were fed an HFD (60% energy from lipids) and assigned to four groups: HFD with 10% fructose (HF_f), HF_f with SLE (HF_fSP), HF_f with exercise (HF_fT), and HF_f with both interventions (HF_fSPT). Bodyweight, lipid profiles, glycemia regulation, and gene expression in soleus muscle (SOL) of lipid and glucose metabolism were assessed. SLE reduced fasting glycemia compared to the HF_f group (1.19-fold) and upregulated Gys1 (1.78-fold) and CPT1A expression (4.13-fold) in SOL. Training improved glucose tolerance, as reflected by reduced area under the curve (P = .01), and upregulated PGC1⍺ and CPT1A expression. The combined intervention (HF_fSPT) decreased bodyweight, increased high-density lipoprotein-cholesterol (1.62-fold), reduced the atherogenic index of plasma (1.39-fold). During training conditions, PGC1⍺ expression was downregulated by SLE (3.03-fold), suggesting a possible interference with exercise-induced muscle adaptation. p38 MAPK, elevated by HFD, was downregulated by SLE, exercise, and their combination (3.20-, 5.14-, and 2.72-fold, respectively). Overall, these findings support the potential of SLE as a complementary strategy to exercise in attenuating HFD-induced metabolic dysfunctions, while also raising concerns about possible interference with training adaptations.

高脂肪饮食（HFD）引起的代谢紊乱会导致肥胖、糖尿病和心血管疾病。虽然螺旋藻液体提取物（SLE）已显示出改善脂质积累和胰岛素抵抗的希望，但体内证据仍然有限，特别是与运动相结合。肌肉活动是代谢的关键调节因子，但在HFD条件下SLE和体能训练的潜在联合效应尚未确定。在这项研究中，年轻雄性大鼠被喂食HFD（60%的能量来自脂质），并被分为四组：HFD加10%果糖（HFf）、HFf加SLE （HFfSP）、HFf加运动（HFfT）和HFf加两种干预（HFfSPT）。评估体重、脂质谱、血糖调节和比目鱼肌（SOL）中脂质和葡萄糖代谢的基因表达。与HFf组相比，SLE降低了空腹血糖（1.19倍），上调了SOL中的Gys1（1.78倍）和CPT1A表达（4.13倍）。训练改善了葡萄糖耐量，曲线下面积减少（P = 0.01），并上调了PGC1和CPT1A表达。联合干预（HFfSPT）降低体重，增加高密度脂蛋白-胆固醇（1.62倍），降低血浆动脉粥样硬化指数（1.39倍）。在训练条件下，PGC1的表达被SLE下调（3.03倍），提示可能干扰运动诱导的肌肉适应。HFD升高的p38 MAPK被SLE、运动及其联合下调（分别为3.20倍、5.14倍和2.72倍）。总的来说，这些发现支持SLE作为运动的补充策略，在减轻hfd诱导的代谢功能障碍方面的潜力，同时也引起了对可能干扰训练适应的担忧。

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引用次数: 0

David Kritchevsky Graduate Student Award for Nutrition Research 大卫·克里切夫斯基营养研究研究生奖

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-11-01 Epub Date: 2025-11-06 DOI: 10.1016/S0271-5317(25)00139-3

引用次数: 0

Editorial office and Board Members 编辑部和董事会成员

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-11-01 Epub Date: 2025-11-06 DOI: 10.1016/S0271-5317(25)00138-1

引用次数: 0

Ellagic acid as a potential therapeutic agent in metabolic syndrome: A systematic review and meta-analysis of glycemic control markers and kidney function tests in animal and clinical studies 鞣花酸作为代谢综合征的潜在治疗剂：动物和临床研究中血糖控制指标和肾功能试验的系统回顾和荟萃分析

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-11-01 Epub Date: 2025-10-03 DOI: 10.1016/j.nutres.2025.10.001

Kornvipa Settakorn , Ratchanon Inpan , Mingkwan Na Takuathung , Nut Koonrungsesomboon

Metabolic syndrome comprises a cluster of abnormal metabolic markers, including hyperglycemia, insulin resistance, hypertension, obesity, and dyslipidemia, that increase the risk of diabetes mellitus, cardiovascular diseases, and associated complications. Prolonged hyperglycemia results in microvascular complications such as nephropathy, while other abnormal metabolic markers contribute to progressive kidney dysfunction. Ellagic acid (EA) exhibits antihyperglycemia and nephroprotective effects. This study evaluated the effects of EA on glycemic control markers and kidney function tests in animal and human models with abnormal metabolic markers and preobesity. Comprehensive searches were conducted in Embase, Scopus, PubMed, and the Cochrane Library. Data were synthesized using meta-analysis, and risk of bias was assessed using SYRCLE’s tool for animal studies and the Risk of Bias 2 tool for human studies. The certainty of evidence in human studies was evaluated using the GRADE approach. Meta-analysis revealed that EA significantly reduced blood glucose concentration (standardized mean differences = –4.03; 95% confidence intervals = –5.02 to –3.04; P < .0001) and improved insulin resistance by lowering homeostatic model assessment of insulin resistance (standardized mean differences = –2.48, 95% confidence intervals =–3.21 to –1.76, P < .0001) in animal studies. However, EA did not significantly affect glucose concentration, insulin, and homeostatic model assessment of insulin resistance in human studies. EA significantly decreased blood urea nitrogen and creatinine in animal studies. Overall, findings from animal studies suggest that EA may have therapeutic potential for improving glycemic control and mitigating kidney complications in metabolic syndrome. However, the absence of significant effects in humans highlights the need for high-quality clinical trials to determine its translational potential.

代谢综合征包括一系列异常代谢标志物，包括高血糖、胰岛素抵抗、高血压、肥胖和血脂异常，它们增加了糖尿病、心血管疾病和相关并发症的风险。长期高血糖可导致微血管并发症，如肾病，而其他异常代谢标志物可导致进行性肾功能障碍。鞣花酸（EA）具有抗高血糖和肾保护作用。本研究评估了EA对代谢标志物异常和肥胖前期动物和人模型的血糖控制指标和肾功能测试的影响。在Embase、Scopus、PubMed和Cochrane图书馆中进行了全面的检索。使用荟萃分析对数据进行综合，使用sycle的动物研究工具和人类研究的风险偏倚2工具评估偏倚风险。使用GRADE方法评估人体研究证据的确定性。荟萃分析显示，在动物研究中，EA可显著降低血糖浓度（标准化平均差异= -4.03；95%置信区间= -5.02至-3.04;P < 0.0001），并通过降低胰岛素抵抗的稳态模型评估（标准化平均差异= -2.48,95%置信区间= -3.21至-1.76,P < 0.0001）改善胰岛素抵抗。然而，在人体研究中，EA对葡萄糖浓度、胰岛素和胰岛素抵抗的稳态模型评估没有显著影响。在动物实验中，EA显著降低血尿素氮和肌酐。总的来说，动物研究结果表明，EA可能具有改善血糖控制和减轻代谢综合征肾脏并发症的治疗潜力。然而，在人类中没有显著的影响，强调需要高质量的临床试验来确定其转化潜力。

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Claims of group-level accuracy for bioelectrical impedance analysis in paediatric obesity: a cautionary note 儿童肥胖的生物电阻抗分析的群体水平准确性的声明：一个警告。

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-10-01 Epub Date: 2025-07-10 DOI: 10.1016/j.nutres.2025.07.002

Jaz Lyons-Reid , Leigh C. Ward , Jo Secher , Mohammad Shahbaz , Benjamin B. Albert , Wayne S. Cutfield , José G.B. Derraik

引用次数: 0

David Kritchevsky Graduate Student Award for Nutrition Research 大卫·克里切夫斯基营养研究研究生奖

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-10-01 Epub Date: 2025-10-11 DOI: 10.1016/S0271-5317(25)00129-0

引用次数: 0

Bridging nutritional mechanisms and global challenges: The 2024 David Kritchevsky award winners 弥合营养机制和全球挑战：2024年大卫·克里切夫斯基奖得主。

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-10-01 Epub Date: 2025-07-17 DOI: 10.1016/j.nutres.2025.07.005

Richard S Bruno

引用次数: 0

Higher dietary n - 3 PUFA and fiber intake are associated with longer leukocyte telomere length: Evidence from a substitution model analysis in the UK Biobank 较高的膳食n - 3 PUFA和纤维摄入量与较长的白细胞端粒长度相关：来自英国生物银行替代模型分析的证据。

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-10-01 Epub Date: 2025-09-04 DOI: 10.1016/j.nutres.2025.08.009

Vasiliki Bountziouka , Christopher P. Nelson , Veryan Codd , Nilesh J. Samani

Telomere attrition is a biomarker of cellular aging, influenced by lifestyle and dietary exposures. The specific role of macronutrient composition, particularly polyunsaturated fatty acids (PUFAs), in telomere dynamics remains insufficiently explored. We hypothesized that higher intake of specific macronutrients, particularly PUFAs, would be positively associated with leukocyte telomere length (LTL). In this cross-sectional study of 143,553 UK Biobank participants aged 40-69 years, we examined associations between macronutrient intake and standardized LTL (z-LTL), measured as the log-transformed telomere repeat to single-copy gene ratio. Dietary intake was assessed using repeated 24-hour web-based dietary recalls. Multivariable linear regression models were used to estimate associations between macronutrients (% of total energy intake) and z-LTL, adjusting for demographic, lifestyle, and clinical covariates. Effect estimates were translated into age-equivalent changes in LTL. Carbohydrate and total fat intake were positively associated with z-LTL, corresponding to age-related LTL differences of approximately 30-40 days. In energy substitution models, n - 3 PUFA intake showed a stronger positive association with z-LTL than other fats, with adherence to recommended intake associated with differences equivalent to over 2 years (P < .0001) of age-related telomere shortening, whereas no evidence of an association for MUFA was observed. Energy-adjusted fibre intake was associated with an age-related change of LTL equivalent to 1 year (P < .0001). These findings suggest that dietary composition, particularly n - 3 PUFA intake, may be linked with LTL in a manner consistent with healthier cellular aging. Further longitudinal and experimental studies are needed to confirm these associations and explore their implications for dietary guidance.

端粒磨损是细胞衰老的生物标志物，受生活方式和饮食暴露的影响。宏量营养素组成的具体作用，特别是多不饱和脂肪酸（PUFAs），在端粒动力学仍未充分探讨。我们假设摄入更多的特定常量营养素，特别是PUFAs，与白细胞端粒长度（LTL）呈正相关。在这项对143,553名年龄在40-69岁之间的英国生物银行参与者的横断面研究中，我们检查了常量营养素摄入量与标准化LTL （z-LTL）之间的关系，以对数转化端粒重复与单拷贝基因比率来测量。通过重复的24小时基于网络的饮食回顾来评估饮食摄入量。多变量线性回归模型用于估计宏量营养素（占总能量摄入的百分比）与z-LTL之间的关系，并对人口统计学、生活方式和临床协变量进行了调整。效应估计被转化为LTL的年龄等效变化。碳水化合物和总脂肪摄入量与z-LTL呈正相关，与年龄相关的LTL差异约为30-40天。在能量替代模型中，与其他脂肪相比，n - 3 PUFA摄入量与z-LTL表现出更强的正相关，坚持推荐摄入量与年龄相关的端粒缩短的差异相当于超过2年（P < 0.0001），而未观察到与MUFA相关的证据。能量调节纤维摄入量与年龄相关的LTL变化（相当于1年）相关（P < 0.0001）。这些发现表明，饮食成分，特别是n - 3 PUFA摄入量，可能与LTL以一种与更健康的细胞衰老一致的方式相关。需要进一步的纵向和实验研究来证实这些关联，并探讨其对饮食指导的影响。

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引用次数: 0

The devil is in the details: Reassessing an isolation attempt reveals methodological breaches in dietary inorganic nitrate research 细节决定成败：重新评估一项分离试验揭示了膳食无机硝酸盐研究方法上的漏洞。

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-10-01 Epub Date: 2025-08-27 DOI: 10.1016/j.nutres.2025.08.008

Jonas Benjamim

引用次数: 0

A higher intake of white-edible-colored fruits and vegetables is associated with lower gastrointestinal cancer risk among Korean adults in a prospective cohort study 在一项前瞻性队列研究中，韩国成年人摄入较多的白色可食用水果和蔬菜与较低的胃肠道癌症风险相关

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-10-01 Epub Date: 2025-08-15 DOI: 10.1016/j.nutres.2025.08.005

Yujin Cho , Jeonghee Lee , Madhawa Gunathilake , Youngyo Kim , Shinyoung Jun , Jeongseon Kim

Although fruits and vegetables were studied botanically in previous studies, few have examined their associations with gastrointestinal (GI) cancer risk based on color classification. Color is familiar to the public and translates phytochemical science into dietary guidance. We hypothesized that the intake of fruits and vegetables would be differently associated with GI cancer risk by color. This cohort study investigated the association between fruit and vegetable colors and GI cancer risk in 11,286 participants from the Cancer Screenee Cohort, who underwent health check-ups at the National Cancer Center between 2007 and 2021. Dietary data were collected through food frequency questionnaires. A Cox proportional hazards regression model evaluated the association between fruit and vegetable color groups (green, orange/yellow, red/purple, and white) and GI cancer risk. Over a mean follow-up of 8 years, 214 GI cancers (esophageal, gastric, small intestine, liver, pancreatic, and colorectal) were identified. Higher total fruit and vegetable intake was associated with reduced GI cancer risk (hazard ratio [HR] = 0.57, 95% confidence interval [CI]: 0.38-0.88, P for trend = .013). Among color groups, white-colored fruits and vegetables (HR = 0.64, 95% CI: 0.41-0.99, P for trend = .021), and white-colored fruits (HR = 0.59, 95% CI: 0.38-0.92, P for trend = .021) were associated with a lower risk of GI cancer after fully adjusting for demographic variables, dietary factors, and comorbidities. Findings were consistent across subgroup analyses. No significant associations were found for green, orange/yellow, or red/purple groups. These results suggest that white-colored fruits and vegetables may contribute to GI cancer prevention.

虽然在以前的研究中对水果和蔬菜进行了植物学研究，但很少有人根据颜色分类来研究它们与胃肠道（GI）癌症风险的关系。颜色为公众所熟悉，并将植物化学科学转化为饮食指导。我们假设水果和蔬菜的摄入量会因颜色不同而与胃肠道癌症风险有不同的关联。这项队列研究调查了来自癌症筛查队列的11286名参与者的水果和蔬菜颜色与胃肠道癌症风险之间的关系，这些参与者在2007年至2021年期间在国家癌症中心接受了健康检查。饮食数据通过食物频率问卷收集。Cox比例风险回归模型评估了水果和蔬菜颜色组（绿色、橙色/黄色、红色/紫色和白色）与胃肠道癌症风险之间的关系。在平均8年的随访中，发现214例胃肠道肿瘤（食管癌、胃癌、小肠癌、肝癌、胰腺癌和结肠直肠癌）。较高的水果和蔬菜总摄入量与降低胃肠道癌症风险相关（风险比[HR] = 0.57, 95%可信区间[CI]: 0.38-0.88，趋势P = 0.013）。在颜色组中，在完全调整了人口统计学变量、饮食因素和合共病后，白色水果和蔬菜（HR = 0.64, 95% CI: 0.41-0.99， P为趋势= 0.021）和白色水果（HR = 0.59, 95% CI: 0.38-0.92， P为趋势= 0.021）与较低的GI癌风险相关。亚组分析结果一致。在绿色、橙色/黄色或红色/紫色组中没有发现显著的关联。这些结果表明，白色的水果和蔬菜可能有助于预防胃肠道癌症。

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