Nutrition Research最新文献_第7页

Spirulina liquid extract regulates gene expression related to glucose and lipid metabolisms of soleus muscle during exercise training in young male Wistar rats fed a high-fat diet 螺旋藻液体提取物在高脂饮食喂养的年轻雄性Wistar大鼠运动训练中调节比目鱼肌糖脂代谢相关基因表达

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-09-15 DOI: 10.1016/j.nutres.2025.09.006

Jordi Vignaud , Céline Loiseau , Martine Côme , Josiane Hérault , Claire Mayer , Olivier Lépine , Lionel Ulmann

Metabolic disorders induced by high-fat diets (HFD) contribute to obesity, diabetes, and cardiovascular diseases. While Spirulina liquid extract (SLE) has shown promise in improving lipid accumulation and insulin resistance, in vivo evidence remains limited, particularly in combination with exercise. Muscle activity is a key regulator of metabolism, but the potential combined effect of SLE and physical training under HFD conditions has not been established. In this study, young male rats were fed an HFD (60% energy from lipids) and assigned to four groups: HFD with 10% fructose (HF_f), HF_f with SLE (HF_fSP), HF_f with exercise (HF_fT), and HF_f with both interventions (HF_fSPT). Bodyweight, lipid profiles, glycemia regulation, and gene expression in soleus muscle (SOL) of lipid and glucose metabolism were assessed. SLE reduced fasting glycemia compared to the HF_f group (1.19-fold) and upregulated Gys1 (1.78-fold) and CPT1A expression (4.13-fold) in SOL. Training improved glucose tolerance, as reflected by reduced area under the curve (P = .01), and upregulated PGC1⍺ and CPT1A expression. The combined intervention (HF_fSPT) decreased bodyweight, increased high-density lipoprotein-cholesterol (1.62-fold), reduced the atherogenic index of plasma (1.39-fold). During training conditions, PGC1⍺ expression was downregulated by SLE (3.03-fold), suggesting a possible interference with exercise-induced muscle adaptation. p38 MAPK, elevated by HFD, was downregulated by SLE, exercise, and their combination (3.20-, 5.14-, and 2.72-fold, respectively). Overall, these findings support the potential of SLE as a complementary strategy to exercise in attenuating HFD-induced metabolic dysfunctions, while also raising concerns about possible interference with training adaptations.

高脂肪饮食（HFD）引起的代谢紊乱会导致肥胖、糖尿病和心血管疾病。虽然螺旋藻液体提取物（SLE）已显示出改善脂质积累和胰岛素抵抗的希望，但体内证据仍然有限，特别是与运动相结合。肌肉活动是代谢的关键调节因子，但在HFD条件下SLE和体能训练的潜在联合效应尚未确定。在这项研究中，年轻雄性大鼠被喂食HFD（60%的能量来自脂质），并被分为四组：HFD加10%果糖（HFf）、HFf加SLE （HFfSP）、HFf加运动（HFfT）和HFf加两种干预（HFfSPT）。评估体重、脂质谱、血糖调节和比目鱼肌（SOL）中脂质和葡萄糖代谢的基因表达。与HFf组相比，SLE降低了空腹血糖（1.19倍），上调了SOL中的Gys1（1.78倍）和CPT1A表达（4.13倍）。训练改善了葡萄糖耐量，曲线下面积减少（P = 0.01），并上调了PGC1和CPT1A表达。联合干预（HFfSPT）降低体重，增加高密度脂蛋白-胆固醇（1.62倍），降低血浆动脉粥样硬化指数（1.39倍）。在训练条件下，PGC1的表达被SLE下调（3.03倍），提示可能干扰运动诱导的肌肉适应。HFD升高的p38 MAPK被SLE、运动及其联合下调（分别为3.20倍、5.14倍和2.72倍）。总的来说，这些发现支持SLE作为运动的补充策略，在减轻hfd诱导的代谢功能障碍方面的潜力，同时也引起了对可能干扰训练适应的担忧。

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引用次数: 0

Carotenoid and vitamin A intake in infants and toddlers (0-24 months) – sources, contribution to vitamin A requirements, and demographic patterns (NHANES 2015-2020) 婴幼儿（0-24个月）类胡萝卜素和维生素A的摄入量——来源、对维生素A需求的贡献和人口统计模式（NHANES 2015-2020）。

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-09-11 DOI: 10.1016/j.nutres.2025.09.004

Taegen Senawong , Thuy Nguyen , Yiming Zhang Mirabile , Katelyn E. Senkus , Salma Musaad , Nancy E. Moran

Carotenoids are fat-soluble pigments found predominantly in fruits and vegetables that contribute to vitamin A requirements and are associated with pediatric neurodevelopment. However, typical amounts and patterns of total carotenoid, pro-vitamin A carotenoid, and vitamin A intake in very young children are poorly defined. The purpose of this study was to describe carotenoid and vitamin A intakes for U.S. children aged 0 to 6, >6 to 12, and >12 to 24 months of age; determine whether intake is significantly different among the 3 age groups; and determine if carotenoid intake patterns differ by demographic characteristics. Cross-sectional dietary intake and demographic data from 1035 infants and toddlers aged 0 to 24 months from the 2015–2020 National Health and Nutrition Examination Survey were analyzed using binomial-gamma hurdle models. Vitamin A from food carotenoids (retinol activity equivalents) provided 19% of the adequate intake for the 0- to 6-month-olds and 36% for the 7- to 12-month-olds, and 57% of the recommended dietary allowance for the 12- to 24-month-olds. Age was associated with intakes of total vitamin A (P < .001), retinol (P < .001), total carotenoids (P < .001), vitamin A from carotenoids (P < .001), and provitamin A from carotenoids (P < .001), after adjusting for sex, race, and poverty status. There was also a significant association of male sex with greater preformed vitamin A intake, and of poverty status with greater intake of preformed vitamin A and decreased vitamin A from carotenoids. Overall, “baby vegetables” were the greatest source of total carotenoid intake in the 0- to 6-month and 6- to 12-month groups, and “mixed dishes” in the 12- to 24-month group. In summary, young children’s carotenoid intake increases significantly with age, and provitamin A carotenoid intake contributes to their vitamin A requirements. “Baby vegetables,” and later, “mixed dishes” are the major sources of carotenoids during this life stage in the United States.

类胡萝卜素是一种脂溶性色素，主要存在于水果和蔬菜中，有助于维生素A的需求，并与儿童神经发育有关。然而，在非常年幼的儿童中，总的类胡萝卜素、维生素A原类胡萝卜素和维生素A的摄入量的典型数量和模式却没有明确的定义。本研究的目的是描述0 - 6个月、6 - 12个月和12 - 24个月的美国儿童的类胡萝卜素和维生素A摄入量；确定三个年龄组之间的摄入量是否有显著差异；并确定类胡萝卜素的摄入模式是否因人口特征而异。采用二项伽玛障碍模型对2015-2020年全国健康与营养调查中1035名0 - 24个月婴幼儿的横断面饮食摄入和人口统计数据进行分析。从食物类胡萝卜素中获取的维生素A（视黄醇活性当量）为0- 6个月大的婴儿提供了充足摄入量的19%，为7- 12个月大的婴儿提供了充足摄入量的36%，为12- 24个月大的婴儿提供了推荐膳食量的57%。在调整性别、种族和贫困状况后，年龄与总维生素A （P < 0.001）、视黄醇（P < 0.001）、总类胡萝卜素（P < 0.001）、类胡萝卜素中的维生素A （P < 0.001）和类胡萝卜素中的维生素原A （P < 0.001）的摄入量相关。此外，男性的性别与预先形成的维生素a的摄入量有关，而贫困状况与预先形成的维生素a的摄入量有关，而类胡萝卜素中维生素a的摄入量则有所减少。总的来说，在0- 6个月和6- 12个月的婴儿组中，“婴儿蔬菜”是类胡萝卜素总摄入量的最大来源，而在12- 24个月的婴儿组中，“混合菜”是类胡萝卜素摄入量的最大来源。综上所述，幼儿的类胡萝卜素摄入量随着年龄的增长而显著增加，而维生素A原类胡萝卜素的摄入量有助于他们对维生素A的需求。在美国，“婴儿蔬菜”和后来的“混合菜”是这个生命阶段类胡萝卜素的主要来源。

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引用次数: 0

Moderate carotenoid intakes protect against sarcopenic obesity among U.S. adults: A cross-sectional study 在美国成年人中，适量摄入类胡萝卜素可以预防肌肉减少性肥胖：一项横断面研究

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-09-04 DOI: 10.1016/j.nutres.2025.09.002

Hang Zhang , Li Li , Yuwei Wang , Yuhan Xie , Bing Chen

Carotenoids have been recognized for their potential health benefits due to their potent anti-inflammatory and antioxidant properties. However, evidence regarding the specific relationship between carotenoid intake and sarcopenic obesity (SO) remains limited. We hypothesized that moderate carotenoid intake was associated with a lower SO risk. A cross-sectional study was conducted involving 10,060 adults aged 18 to 59 from the National Health and Nutrition Examination Survey 2011-2018. Whole-body composition was assessed by dual-energy X-ray absorptiometry, while carotenoid intake was obtained through two 24-hour dietary recall interviews. Weighted logistic regression models, stratified analyses, restricted cubic spline analyses, and sensitivity analyses were utilized for this study. The weighted prevalence of SO was 7.51%. Weighted logistic regression revealed that dietary α-carotene, β-carotene, and β-cryptoxanthin intake was inversely associated with SO risk after accounting for various variables. Age-stratified analyses revealed a significant inverse association between α-carotene intake and SO risk among adults aged 40 to 59, whereas β-carotene and β-cryptoxanthin exhibited similar inverse relationships in the 18 to 39 age group. The sex-stratified analysis demonstrated that the highest tertile of α-carotene, β-carotene, and β-cryptoxanthin intake was inversely correlated with the risk of SO among females. Restricted cubic spline regression analysis revealed a U-shaped association between dietary intake of α-carotene, β-carotene, and β-cryptoxanthin with SO risk, particularly in 40-59-year-olds and females. In conclusion, moderate dietary α-carotene (0.77 mg/day), β-carotene (3.93 mg/day), and β-cryptoxanthin (0.19 mg/day) consumption was associated with a lower SO risk. The relationship between these carotenoids and SO was nonlinear, particularly among individuals aged 40 to 59 years and in females.

类胡萝卜素因其强大的抗炎和抗氧化特性而被公认具有潜在的健康益处。然而，关于类胡萝卜素摄入和肌肉减少性肥胖（SO）之间具体关系的证据仍然有限。我们假设适量的类胡萝卜素摄入与较低的SO风险相关。研究人员对2011-2018年全国健康与营养调查中10060名18至59岁的成年人进行了横断面研究。通过双能x线吸收仪评估全身成分，而通过两次24小时饮食回忆访谈获得类胡萝卜素摄入量。本研究采用加权逻辑回归模型、分层分析、限制三次样条分析和敏感性分析。SO加权患病率为7.51%。加权logistic回归分析结果显示，考虑各种因素后，膳食α-胡萝卜素、β-胡萝卜素和β-隐黄质摄入量与SO风险呈负相关。年龄分层分析显示，在40至59岁的成年人中，α-胡萝卜素摄入量与SO风险呈显著负相关，而在18至39岁的年龄组中，β-胡萝卜素和β-隐黄质表现出类似的负相关关系。性别分层分析表明，女性α-胡萝卜素、β-胡萝卜素和β-隐黄质摄入量的最高分位数与SO的风险呈负相关。限制性三次样条回归分析显示，饮食中α-胡萝卜素、β-胡萝卜素和β-隐黄质的摄入量与SO风险呈u型相关，特别是在40-59岁的女性和女性中。综上所述，饲粮中α-胡萝卜素（0.77 mg/d）、β-胡萝卜素（3.93 mg/d）和β-隐黄质（0.19 mg/d）摄入量适中与较低的SO风险相关。这些类胡萝卜素与SO之间的关系是非线性的，特别是在40至59岁的个体和女性中。

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引用次数: 0

Bioaccessible compounds from bean (Phaseolus vulgaris L.) landraces activate PPARγ in transiently transfected HepG2 cells 从豆（Phaseolus vulgaris L.）地方种中提取的生物可及化合物可激活瞬时转染的HepG2细胞中的PPARγ

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-09-04 DOI: 10.1016/j.nutres.2025.09.001

Pia Eckhof , Nélida Nina , Sarah Bauer , Thomas A Kufer , Jan Frank , Felipe Jiménez-Aspee

Common beans (Phaseolus vulgaris L.) are a nutrient-dense staple food associated with a reduced risk of noncommunicable chronic diseases. One proposed mechanism involves the modulation of nuclear receptors, particularly peroxisome proliferator-activated receptors (PPARs), which are key regulators of lipid and carbohydrate metabolism. In this study, we evaluated the effects of in vitro digested flours, secondary metabolite-enriched extracts (SMEEs), their fractions, and selected representative phytochemicals from 14 landraces and 2 commercial P. vulgaris samples to directly activate PPARs and other nuclear receptors using a luciferase reporter assay in transiently transfected HepG2 cells. We hypothesized that bioaccessible compounds from the digested landraces would directly activate PPARγ in HepG2 cells. Digested flours from landraces such as Magnum and Peumo significantly activated both PPARγ1 and PPARγ2, reaching values up to 1.54-fold higher than the controls (P < .05). Corresponding SMEEs showed stronger activities, with up to 2.32-fold activation compared to the controls (P < .05). In contrast, none of the polarity-based fractions or the major identified phytochemicals (kaempferol-3-O-glycoside, sojasaponin Ba and Bb) showed significant effects. These findings demonstrate that digested P. vulgaris matrices contain bioaccessible compounds capable of directly activating PPARγ in HepG2 cells, likely through synergistic interactions or unidentified constituents. This mechanistic evidence supports the functional relevance of traditional bean landraces in precision nutrition strategies targeting metabolic health.

普通豆类（Phaseolus vulgaris L.）是一种营养丰富的主食，与降低非传染性慢性病的风险有关。一种被提出的机制涉及核受体的调节，特别是过氧化物酶体增殖激活受体（PPARs），它们是脂质和碳水化合物代谢的关键调节因子。在这项研究中，我们评估了体外消化的面粉、次级代谢物富集提取物（SMEEs）、它们的组分，以及从14个地方品种和2个商业紫荆样品中选择的具有代表性的植物化学物质，在瞬时转染的HepG2细胞中直接激活ppar和其他核受体。我们假设从消化的地方菌种中提取的生物可及化合物会直接激活HepG2细胞中的PPARγ。Magnum和Peumo等地方品种消化后的面粉对ppar γ - 1和ppar γ - 2的活性均显著提高，达到对照组的1.54倍（P < 0.05）。相应的中小企业表现出更强的活性，与对照组相比，激活率高达2.32倍（P < 0.05）。相反，基于极性的部分或主要鉴定的植物化学物质（山奈酚-3- o -糖苷，sojasaponin Ba和Bb）均没有显着作用。这些发现表明，消化的寻常草基质含有能够直接激活HepG2细胞中的PPARγ的生物可及化合物，可能是通过协同相互作用或未知成分。这一机制证据支持了传统大豆地方品种在针对代谢健康的精确营养策略中的功能相关性。

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引用次数: 0

David Kritchevsky Graduate Student Award for Nutrition Research 大卫·克里切夫斯基营养研究研究生奖

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-09-01 DOI: 10.1016/S0271-5317(25)00114-9

引用次数: 0

Editorial office and Board Members 编辑部和董事会成员

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-09-01 DOI: 10.1016/S0271-5317(25)00113-7

引用次数: 0

Urinary Iodine/Creatinine as an Indicator of Iodine Status in Lactating Women: Optimal Collection Time Between 0-8 Hours 尿碘/肌酐作为哺乳期妇女碘状态的指标：最佳采集时间在0-8小时之间

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-08-21 DOI: 10.1016/j.nutres.2025.08.006

Qi Meng , Duan Li , Ting Wang , Qi Jin , Fei Li , Meina Ji , Hexi Zhang , Wenxing Guo , Wanqi Zhang

The urinary iodine/creatinine ratio (UI/Cr) has been recognized as a stable indicator for assessing iodine nutrition status. However, data regarding UI/Cr in lactating women are relatively limited. This study aimed to explore the variation regularity of spot UI/Cr and to provide the optimal time for urine collection. Twenty-two healthy lactating women were recruited for a 7-day iodine metabolism experiment. Daily iodine intake was accurately measured and calculated; all urine samples from each participant were collected separately over the 7-day period, and urinary iodine and urinary creatinine were tested. Spot UI/Cr showed minimal variation between 00:00 and 08:00, with significant changes after 08:00. The 24-hour period was divided into six segments, with the smallest coefficient of variation observed in the 00:00 to 03:59 period. The mixed-effects model analysis revealed that spot UI/Cr during the 0:00 to 3:59 period exhibited the strongest correlation with 24-hour UI/Cr (β = 0.82, P < .001), as well as with 24-hour urinary iodine excretion (β = 0.49, P < .001). Additionally, spot UI/Cr during the 4:00 to 7:59 period demonstrated the strongest correlation with total iodine intake (β = 0.54, P < .001), while spot UI/Cr during the 20:00 to 23:59 period showed the strongest correlation with the total iodine intake of the previous day (β = 0.41, P < .001). As UI/Cr is influenced by dietary iodine and its variation increases after eating, it is recommended that urine collection time for assessing the iodine nutritional status of lactating women using spot UI/Cr be set between 0:00 and 08:00.

尿碘/肌酐比值（UI/Cr）已被公认为评价碘营养状况的稳定指标。然而，关于哺乳期妇女尿失禁/尿失禁的数据相对有限。本研究旨在探讨尿样UI/Cr的变化规律，为收集尿液提供最佳时机。选取22名健康哺乳期妇女进行为期7天的碘代谢实验。准确测量和计算每日碘摄入量；在7天的时间内，分别收集所有参与者的尿液样本，并检测尿碘和尿肌酐。现货UI/Cr在00:00 - 08:00之间变化最小，08:00之后变化显著。24小时时段被划分为6个时间段，其中00:00 ~ 03:59时段变异系数最小。混合效应模型分析显示，在0:00 ~ 3:59时段，尿样UI/Cr与24小时尿样UI/Cr的相关性最强（β = 0.82, P < .001），与24小时尿碘排泄量的相关性最强（β = 0.49, P < 001）。4 ~ 7∶59与总碘摄入量相关性最强（β = 0.54, P < 0.001）， 20∶00 ~ 23∶59与前一天总碘摄入量相关性最强（β = 0.41, P < 0.001）。由于UI/Cr受膳食碘的影响，且进食后其变化会增大，因此建议采尿时间选择在0:00 - 08:00之间，以此来评价哺乳期妇女的碘营养状况。

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引用次数: 0

A higher intake of white-edible-colored fruits and vegetables is associated with lower gastrointestinal cancer risk among Korean adults in a prospective cohort study 在一项前瞻性队列研究中，韩国成年人摄入较多的白色可食用水果和蔬菜与较低的胃肠道癌症风险相关

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-08-15 DOI: 10.1016/j.nutres.2025.08.005

Yujin Cho , Jeonghee Lee , Madhawa Gunathilake , Youngyo Kim , Shinyoung Jun , Jeongseon Kim

Although fruits and vegetables were studied botanically in previous studies, few have examined their associations with gastrointestinal (GI) cancer risk based on color classification. Color is familiar to the public and translates phytochemical science into dietary guidance. We hypothesized that the intake of fruits and vegetables would be differently associated with GI cancer risk by color. This cohort study investigated the association between fruit and vegetable colors and GI cancer risk in 11,286 participants from the Cancer Screenee Cohort, who underwent health check-ups at the National Cancer Center between 2007 and 2021. Dietary data were collected through food frequency questionnaires. A Cox proportional hazards regression model evaluated the association between fruit and vegetable color groups (green, orange/yellow, red/purple, and white) and GI cancer risk. Over a mean follow-up of 8 years, 214 GI cancers (esophageal, gastric, small intestine, liver, pancreatic, and colorectal) were identified. Higher total fruit and vegetable intake was associated with reduced GI cancer risk (hazard ratio [HR] = 0.57, 95% confidence interval [CI]: 0.38-0.88, P for trend = .013). Among color groups, white-colored fruits and vegetables (HR = 0.64, 95% CI: 0.41-0.99, P for trend = .021), and white-colored fruits (HR = 0.59, 95% CI: 0.38-0.92, P for trend = .021) were associated with a lower risk of GI cancer after fully adjusting for demographic variables, dietary factors, and comorbidities. Findings were consistent across subgroup analyses. No significant associations were found for green, orange/yellow, or red/purple groups. These results suggest that white-colored fruits and vegetables may contribute to GI cancer prevention.

虽然在以前的研究中对水果和蔬菜进行了植物学研究，但很少有人根据颜色分类来研究它们与胃肠道（GI）癌症风险的关系。颜色为公众所熟悉，并将植物化学科学转化为饮食指导。我们假设水果和蔬菜的摄入量会因颜色不同而与胃肠道癌症风险有不同的关联。这项队列研究调查了来自癌症筛查队列的11286名参与者的水果和蔬菜颜色与胃肠道癌症风险之间的关系，这些参与者在2007年至2021年期间在国家癌症中心接受了健康检查。饮食数据通过食物频率问卷收集。Cox比例风险回归模型评估了水果和蔬菜颜色组（绿色、橙色/黄色、红色/紫色和白色）与胃肠道癌症风险之间的关系。在平均8年的随访中，发现214例胃肠道肿瘤（食管癌、胃癌、小肠癌、肝癌、胰腺癌和结肠直肠癌）。较高的水果和蔬菜总摄入量与降低胃肠道癌症风险相关（风险比[HR] = 0.57, 95%可信区间[CI]: 0.38-0.88，趋势P = 0.013）。在颜色组中，在完全调整了人口统计学变量、饮食因素和合共病后，白色水果和蔬菜（HR = 0.64, 95% CI: 0.41-0.99， P为趋势= 0.021）和白色水果（HR = 0.59, 95% CI: 0.38-0.92， P为趋势= 0.021）与较低的GI癌风险相关。亚组分析结果一致。在绿色、橙色/黄色或红色/紫色组中没有发现显著的关联。这些结果表明，白色的水果和蔬菜可能有助于预防胃肠道癌症。

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引用次数: 0

Low serum 25 hydroxyvitamin D Is associated with severe metabolic dysfunction-associated steatotic liver disease in individuals with overweight/obesity: A cross-sectional study 低血清25羟维生素D与超重/肥胖患者严重代谢功能障碍相关的脂肪变性肝病相关：一项横断面研究

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-08-08 DOI: 10.1016/j.nutres.2025.08.004

Yan Li , Minglan Yang , Jiang Yue , Jie Chen , Zixuan Wang , Yicheng Qi , Qianjing Liu , Qing Lu , Jing Ma

The role of vitamin D status in metabolic dysfunction-associated steatotic liver disease (MASLD) remains controversial. Furthermore, research evaluating the relationship between vitamin D status and abdominal fat distribution is limited. Therefore, we hypothesized that serum vitamin D is inversely associated with the severity of liver fat content (LFC) in populations with overweight/obesity. A total of 201 subjects with body mass index ≥23 kg/m² were classified by 25 hydroxyvitamin D (25 (OH) D) concentration as either vitamin D deficiency (<20 ng/mL) or vitamin D normal (≥20 ng/mL). Magnetic resonance imaging-proton density fat fraction was used to measure fat accumulation in the liver, pancreas, and abdomen subcutaneous and visceral. The LFC and subcutaneous adipose tissue (SAT) were significantly higher in the vitamin D deficient group compared to the normal vitamin D group (P < .05). However, there were no significant differences in visceral adipose tissue or pancreatic fat content between the 2 groups. Additionally, as the severity of LFC and SAT increases in individuals with overweight/obesity, serum 25 (OH) D concentration significantly decreases (P < .05). Further multivariate-adjusted logistic regression analysis revealed that individuals in the highest tertile of 25 (OH) D exposure exhibited lower risks of severe hepatic steatosis compared to those in the lowest tertile (T3 vs. T1, OR 0.26, 95% CI 0.10-0.67, P = .01). Our results identify a significant inverse association between serum 25 (OH) D concentration and severe MASLD in individuals with overweight/obesity. Further research is needed to explore the metabolic mechanisms underlying this association and their implications for liver protection.

维生素D在代谢功能障碍相关脂肪变性肝病（MASLD）中的作用仍然存在争议。此外，评估维生素D水平与腹部脂肪分布之间关系的研究有限。因此，我们假设在超重/肥胖人群中，血清维生素D与肝脏脂肪含量（LFC）的严重程度呈负相关。201名体重指数≥23 kg/m2的受试者按25羟维生素D （25 (OH) D）浓度分为维生素D缺乏症（≤20 ng/mL）和维生素D正常（≥20 ng/mL）两组。磁共振成像-质子密度脂肪分数用于测量肝脏、胰腺、腹部、皮下和内脏的脂肪堆积。维生素D缺乏组的LFC和皮下脂肪组织（SAT）明显高于正常维生素D组（P < 0.05）。然而，两组之间内脏脂肪组织和胰腺脂肪含量无显著差异。此外，随着超重/肥胖个体LFC和SAT严重程度的增加，血清25 (OH) D浓度显著降低（P < 0.05）。进一步的多变量调整logistic回归分析显示，暴露于25 (OH) D水平最高的个体比暴露于25 (OH) D水平最低的个体发生严重肝脂肪变性的风险更低（T3 vs. T1, OR 0.26, 95% CI 0.10-0.67, P = 0.01）。我们的研究结果表明，在超重/肥胖个体中，血清25 (OH) D浓度与严重MASLD之间存在显著的负相关。需要进一步的研究来探索这种关联背后的代谢机制及其对肝脏保护的影响。

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引用次数: 0

Dietary vitamin E intake is associated with lower mortality among individuals with metabolic dysfunction-associated steatotic liver disease 在代谢功能障碍相关的脂肪变性肝病患者中，膳食维生素E摄入量与较低的死亡率相关

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2025-08-06 DOI: 10.1016/j.nutres.2025.08.001

Yajie Peng , Wanhong Wu , Lin Chen , Chao Xu , Xuelian Xiong

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prominent global health issue within the realm of chronic liver diseases. Dietary interventions are of utmost importance in its management. This research, grounded in data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018 and the National Death Index (NDI), was designed to clarify the association between dietary vitamin E intake and mortality among MASLD patients. Our hypothesis proposed that higher dietary vitamin E intake might be inversely associated with a lower risk of mortality in this population. A total of 7883 MASLD patients were enrolled. Their dietary vitamin E intake was accurately measured via the USDA's standardized method, and numerous confounding factors were comprehensively taken into account. The findings indicated that a higher dietary vitamin E intake was significantly linked to a decreased risk of both all-cause and cardiovascular disease (CVD) mortality in MASLD patients. Kaplan-Meier curves and Cox regression models vividly depicted this inverse correlation. Subgroup and sensitivity analyses further verified the reliability of the results, showing that nonsedentary patients were more sensitive to the protective effects of vitamin E. Notably, the improvement of mortality was particularly significant in patients with increased total bilirubin and fibrotic liver. This study offers valuable perspectives on the potential role of dietary vitamin E in MASLD management. It suggests that increasing dietary vitamin E intake could be a promising preventive approach.

代谢功能障碍相关脂肪变性肝病（MASLD）已成为慢性肝病领域中一个突出的全球健康问题。饮食干预对其管理至关重要。这项研究基于1999年至2018年国家健康与营养调查（NHANES）和国家死亡指数（NDI）的数据，旨在阐明MASLD患者膳食维生素E摄入量与死亡率之间的关系。我们的假设提出，在这一人群中，较高的膳食维生素E摄入量可能与较低的死亡率风险呈负相关。共有7883名MASLD患者入组。他们的膳食维生素E摄入量是通过美国农业部的标准化方法精确测量的，并综合考虑了许多混杂因素。研究结果表明，较高的膳食维生素E摄入量与MASLD患者全因和心血管疾病（CVD）死亡率的降低显著相关。Kaplan-Meier曲线和Cox回归模型生动地描述了这种负相关关系。亚组分析和敏感性分析进一步验证了结果的可靠性，表明不久坐的患者对维生素e的保护作用更敏感。值得注意的是，总胆红素升高和肝纤维化的患者死亡率的改善尤为显著。本研究为膳食维生素E在MASLD管理中的潜在作用提供了有价值的观点。这表明增加饮食中维生素E的摄入量可能是一种很有希望的预防方法。

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