Nutrition Research最新文献_第7页

Higher sweet beverage consumption was associated with increased gestational weight gain and birth weight: A Chinese cohort study 甜饮料消费量增加与妊娠体重增加和出生体重增加有关：一项中国队列研究

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-20 DOI: 10.1016/j.nutres.2024.09.013

Shuang Zhang, Cuiping Zhang, Jia Guo, Baojuan Li, Weiqin Li, Jinnan Liu, Lingyan Feng, Peng Wang

Diet during pregnancy is crucial to maternal metabolism and fetal development, so exploring the most potent food risk factor could improve maternal and child health. In this study, we investigated the diet and lifestyle of 833 healthy pregnant women in the second trimester from November 2020 to August 2021. Based on the Tianjin Antenatal Care System in China, we followed up with these women and recorded their gestational weight gain (GWG) and newborn birth weight. We conducted a dietary survey through FFQ based on the food groups recommended by the Chinese Dietary Guidelines and included common ultra-processed foods. We collected 219 semi-quantitative FFQs and 614 self-reported FFQs for analysis. According to the consumption frequency of 12 food groups, 4 dietary patterns were extracted by principal component analysis. We analyzed the associations of food energy, consumption frequency, and dietary patterns with GWG and birth weight, especially GWG in the first and second trimesters (f-GWG). The results showed that f-GWG was positively correlated with food energy. Beverage consumption was associated with f-GWG (r = 0.288, P = .026) in obese pregnant women. A dietary pattern that favors high consumption of ultra-processed foods (fried foods, baked desserts, and sweet beverages) was associated with increased GWGs. Non-obesity women with high consumption of baked desserts and sweet beverages had higher GWGs (P < .05). After adjusting for confounding factors (including total energy, physical activity, and sleep quality), only sweet beverage consumption was associated with f-GWG (β 0.498, 95%CI 0.153-0.843) and birth weight (β 0.124, 95%CI 0.009-0.240). Sweet beverage consumption is a key adjustable risk factor for prenatal care.

孕期饮食对母体的新陈代谢和胎儿的发育至关重要，因此，探索最有效的食物风险因素可以改善母婴健康。在这项研究中，我们调查了 833 名健康孕妇在 2020 年 11 月至 2021 年 8 月期间的后三个月的饮食和生活方式。在中国天津产前保健系统的基础上，我们对这些孕妇进行了随访，并记录了她们的妊娠体重增加（GWG）和新生儿出生体重。我们根据《中国居民膳食指南》推荐的食物类别进行了膳食调查，其中包括常见的超加工食品。我们收集了 219 份半定量 FFQ 和 614 份自报 FFQ 进行分析。根据 12 种食物的摄入频率，通过主成分分析提取出 4 种膳食模式。我们分析了食物能量、摄入频率和膳食模式与体重指数和出生体重的关系，尤其是妊娠头三个月和后三个月的体重指数（f-GWG）。结果显示，f-GWG 与食物能量呈正相关。肥胖孕妇的饮料消耗量与 f-GWG 相关（r = 0.288，P = .026）。偏爱大量食用超加工食品（油炸食品、烘焙甜点和甜饮料）的饮食模式与 GWG 的增加有关。大量食用烘焙甜点和甜饮料的非肥胖妇女的总血糖值更高（P < .05）。在对混杂因素（包括总能量、体力活动和睡眠质量）进行调整后，只有甜饮料消费与 f-GWG （β 0.498，95%CI 0.153-0.843）和出生体重（β 0.124，95%CI 0.009-0.240）相关。饮用甜饮料是产前护理的一个关键可调整风险因素。

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引用次数: 0

Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men 每天补充 40 毫克的亚精胺对循环多胺的影响微乎其微：一项针对老年男性的探索性双盲随机对照试验

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-19 DOI: 10.1016/j.nutres.2024.09.012

Patrick Keohane , Jeremy R. Everett , Rui Pereira , Chad M. Cook , Traci M. Blonquist , Eunice Mah

This study represents the first investigation into the safety of a novel, high-purity spermidine trihydrochloride supplement (hpSPD) in humans. Spermidine, a natural compound found in various foods, has demonstrated potential health benefits in animal and epidemiological studies. However, evidence from clinical trials and safety evaluations of spermidine supplements is limited because pure spermidine for human administration has not been available. In this randomized, double-blind, within-subject and placebo-controlled trial, 37 healthy men (age 50–70 years; body mass index, 18.5–28 kg/m²) were administered either hpSPD or a placebo. We hypothesized that 7-day and 28-day dosing of 40 mg/day of hpSPD would have minimal effects on safety, although metabolic and polyamine homeostasis has not previously been examined at this dosage level. Consistent with our hypothesis, 40 mg/day hpSPD did not result in any significant changes in clinical, lipids, chemistry, or hematological parameters compared to placebo. Compliance was high, and no study product-related adverse events were reported. Substantial changes in serum and urine polyamine concentrations were not observed following hpSPD supplementation, suggesting effective homeostatic control of full-dose highly purified spermidine supplements with no evidence of adaptation of spermidine metabolism at 40 mg/day. These findings suggest that hpSPD at 40 mg/day for up to 28 days is safe and well-tolerated in healthy older men. The study is consistent with preclinical results and provides important evidence supporting the safety of high-purity spermidine supplementation, enabling further research with single-molecule spermidine to investigate its potential biology for improving human health. This trial was registered at clinicaltrials.gov (NCT05459961).

这项研究首次调查了一种新型高纯度三盐酸精胺补充剂（hpSPD）对人体的安全性。精脒是一种存在于各种食物中的天然化合物，在动物和流行病学研究中已被证明具有潜在的健康益处。然而，由于还没有供人类服用的纯品精胺，因此精胺补充剂的临床试验和安全性评估证据非常有限。在这项随机、双盲、受试者内和安慰剂对照试验中，37 名健康男性（年龄 50-70 岁；体重指数 18.5-28 kg/m2）服用了 hpSPD 或安慰剂。我们的假设是，每天服用 40 毫克 hpSPD 的 7 天和 28 天剂量对安全性的影响极小，尽管此前尚未在这一剂量水平上对代谢和多胺稳态进行过研究。与我们的假设一致，与安慰剂相比，40 毫克/天的 hpSPD 不会导致临床、血脂、化学或血液学参数发生任何显著变化。患者的依从性很高，也未报告与研究产品相关的不良事件。补充hpSPD后，血清和尿液中的多胺浓度没有发生重大变化，这表明全剂量高纯度亚精胺补充剂能有效控制体内平衡，没有证据表明服用40毫克/天的亚精胺代谢会发生适应性变化。这些研究结果表明，健康老年男性每天服用 40 毫克的 hpSPD 长达 28 天是安全和耐受性良好的。该研究与临床前研究结果一致，并提供了支持高纯度亚精胺补充剂安全性的重要证据，有助于进一步研究单分子亚精胺，探讨其在改善人类健康方面的潜在生物学作用。该试验已在 clinicaltrials.gov 注册（NCT05459961）。

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引用次数: 0

Epidemiological and transcriptome data identify association between iron overload and metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis 流行病学和转录组数据确定了铁超载与代谢功能障碍相关的脂肪肝和肝纤维化之间的联系。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-18 DOI: 10.1016/j.nutres.2024.09.011

Chunling Li , Mengqi Qu , Xiangfeng Tian , Wenyi Zhuang , Meng Zhu , Shengxia Lv , Yongsheng Zhang , Feiye Zhu

The primary objective of this study was to examine the association between iron overload (IO), metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatic fibrosis. We hypothesized that there is a significant association. Data from the NHANES (2017-2020) were analyzed to explore IO's impact on MASLD and hepatic fibrosis in U.S. adults. We assessed serum ferritin, controlled attenuation parameter (CAP), liver stiffness measurement (LSM), and various covariates. Gene expression data were sourced from the FerrDb V2 and GEO databases. Differential gene expression analysis, Protein-Protein Interaction (PPI) Network construction, and Gene Ontology (GO) and KEGG pathway enrichment analyses were performed. The study verified the link between MASLD, hepatic fibrosis, and iron overload hub genes. This study of 5927 participants, averaging 46.78 years of age, revealed significant correlations between serum ferritin and CAP, LSM, after adjusting for covariates. Threshold effect analysis indicated nonlinear associations between serum ferritin and CAP, LSM, with distinct patterns observed by age and gender. Moreover, the area under the ROC curve for serum ferritin with MASLD and hepatic fibrosis was 0.8272 and 0.8376, respectively, demonstrating its performance in assessing these conditions. Additionally, molecular analyses identified potential hub genes associated with iron overload and MASLD, and hepatic fibrosis, revealing the underlying mechanisms. Our study findings reveal an association between iron overload, MASLD, and hepatic fibrosis. Additionally, the hub genes may be implicated in iron overload and subsequently contribute to the progression of MASLD and hepatic fibrosis. These findings support precision nutrition strategies.

本研究的主要目的是探讨铁超载（IO）、代谢功能障碍相关性脂肪性肝病（MASLD）和肝纤维化之间的关联。我们假设两者之间存在显著关联。我们分析了 NHANES（2017-2020 年）的数据，以探讨 IO 对美国成年人 MASLD 和肝纤维化的影响。我们评估了血清铁蛋白、受控衰减参数（CAP）、肝脏硬度测量（LSM）和各种协变量。基因表达数据来自 FerrDb V2 和 GEO 数据库。研究人员进行了差异基因表达分析、蛋白质-蛋白质相互作用（PPI）网络构建、基因本体（GO）和 KEGG 通路富集分析。研究验证了 MASLD、肝纤维化和铁超载枢纽基因之间的联系。这项针对 5927 名参与者（平均年龄 46.78 岁）的研究显示，在调整协变量后，血清铁蛋白与 CAP、LSM 之间存在显著相关性。阈值效应分析表明，血清铁蛋白与 CAP、LSM 之间存在非线性关联，不同年龄和性别的人之间的关联模式各不相同。此外，血清铁蛋白与 MASLD 和肝纤维化的 ROC 曲线下面积分别为 0.8272 和 0.8376，显示了其在评估这些情况时的性能。此外，分子分析还发现了与铁超载、MASLD 和肝纤维化相关的潜在枢纽基因，揭示了其潜在机制。我们的研究结果揭示了铁超载、MASLD 和肝纤维化之间的关联。此外，枢纽基因可能与铁超载有关，并随后导致 MASLD 和肝纤维化的进展。这些发现为精准营养策略提供了支持。

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引用次数: 0

Intestinal-level anti-inflammatory bioactivities of whole wheat: Rationale, design, and methods of a randomized, controlled, crossover dietary trial in adults with prediabetes 全麦的肠道级抗炎生物活性：糖尿病前期成人随机对照交叉膳食试验的原理、设计和方法。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-18 DOI: 10.1016/j.nutres.2024.09.010

Sisi Cao , Jillian T. Pierson , Ariana H. Bond , Shiqi Zhang , Andrew Gold , Huan Zhang , Kaitlyn M. Zamary , Palmer Moats , Matthew D. Teegarden , Devin G. Peterson , Xiaokui Mo , Jiangjiang Zhu , Richard S. Bruno

Randomized controlled trials (RCT) demonstrate that whole wheat consumption improves glycemia. However, substantial inter-individual variation is often observed, highlighting that dietary whole grain recommendations may not support the health of all persons. The objective of this report is to describe the rationale and design of a planned RCT aimed at establishing the gut microbiota and metabolome signatures that predict whole wheat-mediated improvements in glucose tolerance in adults with prediabetes. It is hypothesized that a controlled diet containing wheat bread (WHEAT; 160 g/day) compared with refined bread (WHITE) will improve glucose tolerance in a gut microbiota-mediated manner. Biospecimens will be collected before and after each 2-week study arm. Testing for oral glucose tolerance and gastrointestinal permeability will be performed post-intervention. Assessments will include oral glucose tolerance (primary outcome) and secondary outcomes including gut microbiota, targeted and untargeted metabolomics of fecal and plasma samples, intestinal and host inflammatory responses, and intestinal permeability. WHEAT is predicted to alleviate glucose intolerance by shifting microbiota composition to increase short-chain fatty acid-producing bacteria while reducing populations implicated in intestinal inflammation, barrier dysfunction, and systemic endotoxemia. Further, benefits from WHEAT are anticipated to correlate with gut-level and systemic metabolomic responses that can help to explain the expected inter-individual variability in glucose tolerance. Thus, knowledge gained from integrating multi-omic responses associating with glucose tolerance could help to establish a precision nutrition-based framework that can alleviate cardiometabolic risk. This framework could inform novel dietary whole grain recommendations by enhancing our understanding of inter-individual responsiveness to whole grain consumption.

随机对照试验（RCT）表明，食用全麦可改善血糖。然而，个体之间往往存在很大差异，这突出表明全谷物膳食建议可能无法支持所有人的健康。本报告旨在描述一项计划中的 RCT 的原理和设计，该 RCT 旨在确定肠道微生物群和代谢组特征，以预测全麦介导的糖尿病前期成人葡萄糖耐量改善情况。假设与精制面包（白面包）相比，控制饮食中含有小麦面包（WHEAT；160 克/天）将通过肠道微生物群介导的方式改善葡萄糖耐量。将在每个为期两周的研究臂之前和之后采集生物样本。干预后将进行口服葡萄糖耐量和胃肠道渗透性测试。评估将包括口服葡萄糖耐量（主要结果）和次要结果，包括肠道微生物群、粪便和血浆样本的靶向和非靶向代谢组学、肠道和宿主炎症反应以及肠道渗透性。据预测，WHEAT 可通过改变微生物群的组成来增加短链脂肪酸细菌的数量，同时减少与肠道炎症、屏障功能障碍和全身性内毒素血症有关的细菌数量，从而缓解葡萄糖不耐受症。此外，WHEAT 的益处预计与肠道和全身代谢组学反应相关，有助于解释葡萄糖耐量的预期个体间差异。因此，整合与葡萄糖耐量相关的多组反应所获得的知识有助于建立一个基于精准营养的框架，从而减轻心脏代谢风险。通过加强我们对全谷物消费的个体间反应的了解，这一框架可为新的全谷物膳食建议提供依据。

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引用次数: 0

Higher docosahexaenoic acid proportions in blood are inversely associated with the prevalence of prediabetes: Evidence from the UK Biobank 血液中较高的二十二碳六烯酸比例与糖尿病前期的发病率成反比：来自英国生物库的证据。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-17 DOI: 10.1016/j.nutres.2024.09.009

Jan Philipp Schuchardt , Andreas Hahn , Theresa Greupner , Nathan L. Tintle , Jason Westra , William S. Harris

Prediabetes and type 2 diabetes mellitus are growing global health concerns, predisposing individuals to various vascular complications. Lifestyle modifications, including dietary interventions, offer promising avenues for prevention and management. Using a multivariable-adjusted model, we analyzed the cross-sectional associations between plasma proportions (% of total fatty acids) of omega-3 polyunsaturated fatty acids (n3 PUFA, including total n3 PUFA, docosahexaenoic acid [DHA], non-DHA n3 PUFA), and glycated hemoglobin A1c (HbA1c) as well as the prevalence of prediabetes in a sample from the UK Biobank cohort. Our hypothesis was that proportions of n3 PUFA, especially DHA, would by inversely associated with the prediabetes prevalence. The sample (n = 92,762; 54.5% females) had an average age of 56 years and was overweight (mean body mass index = 27). The mean plasma DHA proportion in the sample was 2.03% (standard deviation [SD] = 0.67%), non-DHA n3 PUFA was 2.41% (SD = 1.02%) and total n3 PUFA was 4.43% (SD = 1.56%). Prediabetic individuals were identified by blood HbA1c proportions between 5.7% and 6.4% (39-46 mmol/mol) according to American Diabetes Association criteria. Each of the three n3 PUFA biomarkers was inversely associated with HbA1c proportions. In particular, DHA showed the strongest inverse association, with an OR of 0.62 (95% confidence intervals: 0.58, 0.67; P < .001) when comparing quintiles 5 to 1 in a fully adjusted model. These findings suggest a potential protective role of n3 PUFA, particularly DHA, in mitigating the risk of having prediabetes. Further prospective investigations are needed to clarify whether long-chain n3 PUFA could function as modifiable factors for prediabetes.

糖尿病前期和 2 型糖尿病是全球日益关注的健康问题，容易导致各种血管并发症。包括饮食干预在内的生活方式调整为预防和管理提供了前景广阔的途径。利用多变量调整模型，我们分析了英国生物库队列样本中血浆中欧米伽-3 多不饱和脂肪酸（n3 PUFA，包括总 n3 PUFA、二十二碳六烯酸 [DHA]、非 DHA n3 PUFA）的比例（占总脂肪酸的百分比）与糖化血红蛋白 A1c (HbA1c) 以及糖尿病前期患病率之间的横断面关联。我们的假设是，n3 PUFA（尤其是 DHA）的比例与糖尿病前期患病率成反比。样本（n = 92,762; 54.5% 为女性）的平均年龄为 56 岁，体重超重（平均体重指数 = 27）。样本血浆中 DHA 的平均比例为 2.03%（标准差 [SD] = 0.67%），非 DHA n3 PUFA 为 2.41%（标准差 = 1.02%），n3 PUFA 总量为 4.43%（标准差 = 1.56%）。根据美国糖尿病协会的标准，血 HbA1c 的比例在 5.7% 和 6.4% 之间（39-46 mmol/mol），即可确定为糖尿病前期患者。三种 n3 PUFA 生物标记物中的每一种都与 HbA1c 比例成反比关系。其中，DHA 的反相关性最强，在完全调整模型中将五分位数 5 与 1 进行比较，其 OR 值为 0.62（95% 置信区间：0.58，0.67；P < .001）。这些研究结果表明，n3 PUFA（尤其是 DHA）在降低糖尿病前期风险方面具有潜在的保护作用。我们需要进一步开展前瞻性研究，以明确长链 n3 PUFA 是否可作为糖尿病前期的可调节因素。

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引用次数: 0

A matter of the metric? Sugar content overestimation is less pronounced in sugar cubes versus grams 计量单位的问题？方糖与克糖相比，糖含量被高估的情况不那么明显。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-14 DOI: 10.1016/j.nutres.2024.09.007

Laura M. König , Harald T. Schupp , Britta Renner

To make healthy food choices, consumers need to be aware of the sugar content of foods. Units act as an environmental cue that might influence sugar content estimation accuracy. The present study (1) tested whether estimations of sugar content are more accurate in sugar cubes vs grams, (2) compared accuracy of sugar content to estimations of the foods’ weight and energy content, and (3) investigated gender, education, and body mass index as potential correlates. A sample of 886 adults was randomly assigned to estimating the sugar content of 10 common foods in grams or cubes. Estimations of sugar content diverged considerably from actual values in both groups (0.22 ≤ Cohen's ds_gram_s ≤ 1.20; 0.20 ≤ Cohen's ds_cubes ≤ 1.10), but were more pronounced for sugar content estimations in grams in 7 out of 10 foods (ts ≥ 4.04, Ps < .001, Cohen's ds ≥ 0.14). Sugar content misestimation was somewhat more pronounced than misestimation of weight (0.05 ≤ Cohen's ds ≤ 1.43) and energy content (0.04 ≤ Cohen's ds ≤ 1.19). Relationships between sugar content misestimation and gender (0.00 ≤ Cohen's ds ≤ 0.33), education (–0.07 ≤ r ≤ 0.11), and body mass index (–0.08 ≤ r ≤ 0.06) were mostly negligible. Although sugar content estimations were somewhat more accurate in sugar cubes vs grams, estimation accuracy is generally low. In addition to promoting consumers’ knowledge through labeling and education, additional avenues for interventions might need to be explored for sizeable effects on food choices.

为了选择健康的食品，消费者需要了解食品的含糖量。单位作为一种环境线索，可能会影响糖含量估计的准确性。本研究(1)测试了以方糖为单位与以克为单位估算糖含量是否更准确；(2)比较了糖含量的准确性与食品重量和能量含量的估算；(3)调查了性别、教育程度和体重指数的潜在相关性。对 886 名成年人进行随机抽样，以克或立方为单位估算 10 种常见食物的含糖量。两组人的糖含量估计值与实际值相差很大（0.22 ≤ Cohen's dsgrams ≤ 1.20；0.20 ≤ Cohen's dscubes ≤ 1.10），但在 10 种食物中有 7 种食物的糖含量估计值以克为单位更为明显（ts ≥ 4.04，Ps < .001，Cohen's ds ≥ 0.14）。糖含量误测比重量误测（0.05 ≤ Cohen's ds ≤ 1.43）和能量误测（0.04 ≤ Cohen's ds ≤ 1.19）更明显。糖含量估计错误与性别（0.00 ≤ Cohen's ds ≤ 0.33）、教育程度（-0.07 ≤ r ≤ 0.11）和体重指数（-0.08 ≤ r ≤ 0.06）之间的关系大多可以忽略不计。虽然方糖与克糖的含糖量估计准确度略高，但估计准确度普遍较低。除了通过标签和教育提高消费者的知识水平外，可能还需要探索更多的干预途径，才能对食品选择产生显著效果。

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引用次数: 0

The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice 高脂饮食和低剂量链脲佐菌素 2 型糖尿病模型可诱导雄性 C57BL/6J 小鼠产生高胰岛素血症和胰岛素抵抗，但不会诱导雌性 C57BL/6J 小鼠产生高胰岛素血症和胰岛素抵抗。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-14 DOI: 10.1016/j.nutres.2024.09.008

Kathryn C. Racine , Lisard Iglesias-Carres , Jacob A. Herring , Kristopher L. Wieland , Peter N. Ellsworth , Jeffery S. Tessem , Mario G. Ferruzzi , Colin D. Kay , Andrew P. Neilson

Translation of preclinical findings on the efficacy of dietary interventions for metabolic disease to human clinical studies is challenging due to the predominant use of male rodents in animal research. Our objective was to evaluate a combined high-fat (HF) diet and low-dose streptozotocin (STZ) model for induction of type-2 diabetes (T2D) in male and female C57BL/6J mice. We hypothesized that T2D biomarkers would differ significantly between sexes. Mice were administered either a low-fat (LF) diet (10% kcal from fat), or HF diet (60% kcal from fat) + STZ injections (30 mg/kg/d for 3 days). Both sexes gained weight and developed impaired postprandial oral glucose tolerance on the HF+STZ treatment compared to LF. Only male mice on HF + STZ developed fasting hyperglycemia, fasting hyperinsulinemia and insulin resistance, suggesting that the underlying causes of postprandial hyperglycemia differed between sexes. Principal component analysis of measures such as body weights, glucose and insulin concentrations indicated metabolic derangement for males only on HF+STZ treatment, while LF group males and both groups of females significantly overlapped. Based on our data, we accept our hypothesis that the combined high-fat diet and low-dose STZ model for T2D phenotypes differs significantly in its effect on mice based on sex. The HF diet + low-dose STZ model is not useful for studying insulin resistance in females. Other models are needed to model T2D, and study the effects of dietary interventions in this disease, in females. Sexual dimorphism remains a significant challenge for both preclinical and clinical research.

由于动物研究主要使用雄性啮齿类动物，因此将饮食干预代谢疾病疗效的临床前研究结果转化为人类临床研究具有挑战性。我们的目的是评估高脂（HF）饮食和低剂量链脲佐菌素（STZ）联合模型在雄性和雌性 C57BL/6J 小鼠中诱导 2 型糖尿病（T2D）的效果。我们假设不同性别小鼠的 T2D 生物标志物会有显著差异。我们给小鼠喂食低脂（LF）饮食（10% 千卡热量来自脂肪）或高脂饮食（60% 千卡热量来自脂肪）+ STZ 注射（30 毫克/千克/天，连续 3 天）。与LF相比，HF+STZ处理的雌雄小鼠体重都有所增加，并出现餐后口服葡萄糖耐量受损。只有雄性小鼠在接受HF+STZ治疗后出现空腹高血糖、空腹高胰岛素血症和胰岛素抵抗，这表明不同性别小鼠餐后高血糖的根本原因不同。对体重、血糖和胰岛素浓度等指标的主成分分析表明，只有接受高频+STZ治疗的男性出现了代谢紊乱，而低频组男性和两组女性的代谢紊乱情况明显重叠。根据我们的数据，我们同意我们的假设，即高脂饮食和低剂量 STZ 联合治疗 T2D 表型模型对小鼠的影响因性别而有显著差异。高脂饮食+低剂量 STZ 模型对研究雌性小鼠的胰岛素抵抗没有帮助。需要其他模型来模拟雌性 T2D，并研究饮食干预对该疾病的影响。性别二形性仍然是临床前和临床研究的一个重大挑战。

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引用次数: 0

Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults 血浆烟酸与中国成人糖尿病患者的高脂血症呈反比。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-14 DOI: 10.1016/j.nutres.2024.09.006

Xuyang Geng , Zefang Lin , Zhixiong Zheng , Qiuping Lin , Taoping Sun , Qing Yang , Yao Deng

Evidence is limited regarding the association of plasma niacin with the risk of hyperlipidemia in participants with diabetes. We aimed to determine the relationship between plasma niacinamide/nicotinic acid and hyperlipidemia in participants with/without diabetes. Plasma niacinamide/nicotinic acid concentrations were measured using high-performance liquid chromatography-tandem mass spectroscopy. Multivariable logistic regression analyses were performed to evaluate the association between plasma niacin and hyperlipidemia in participants with diabetes and nondiabetes in a cross-sectional study. Compared to the first quartile, plasma nicotinamide, nicotinic acid, and niacin (nicotinamide plus nicotinic acid) were associated with a 54%, 50%, and 52% lower risk of hyperlipidemia in diabetic participants, respectively, but no significant association was observed in nondiabetic participants. These inverse associations persisted across subgroups stratified by sex, age, body mass index, smoking status, alcohol consumption, and physical activity. In addition, the fully adjusted odds ratios (95% confidence intervals) for hypercholesterolemia and hypertriglyceridemia among diabetic participants were 0.54 (0.38, 0.77) and 0.61 (0.44, 0.85), respectively, when comparing to the first quartile of plasma niacin concentrations (all P_trend < .001). This study of 2647 participants observed that plasma niacin was inversely associated with hyperlipidemia in those with diabetes.

有关糖尿病患者血浆烟酸与高脂血症风险之间关系的证据很有限。我们旨在确定糖尿病患者/非糖尿病患者血浆烟酰胺/烟酸与高脂血症之间的关系。我们使用高效液相色谱-串联质谱法测定了血浆中烟酰胺/烟酸的浓度。在一项横断面研究中，对糖尿病和非糖尿病参试者的血浆烟酸与高脂血症之间的关系进行了多变量逻辑回归分析。与第一四分位数相比，糖尿病患者血浆中烟酰胺、烟酸和烟酸（烟酰胺加烟酸）分别与54%、50%和52%的高脂血症风险降低相关，但在非糖尿病患者中未观察到明显的相关性。在按性别、年龄、体重指数、吸烟状况、饮酒量和体力活动进行分层的亚组中，这些反向关系依然存在。此外，与血浆烟酸浓度的第一四分位数相比，糖尿病参与者中高胆固醇血症和高甘油三酯血症的完全调整几率比（95% 置信区间）分别为 0.54 (0.38, 0.77) 和 0.61 (0.44, 0.85)（所有 Ptrend < .001）。这项对 2647 名参与者进行的研究发现，血浆烟酸与糖尿病患者的高脂血症呈反向关系。

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引用次数: 0

The MTHFR C677T/A1298C polymorphism is associated with increased risk of microangiopathy in type 2 diabetes mellitus: A systematic review and meta-analysis MTHFR C677T/A1298C 多态性与 2 型糖尿病微血管病变风险增加有关：系统回顾与荟萃分析

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-10 DOI: 10.1016/j.nutres.2024.08.004

Yuxin Zhang , Yanjiao Zhang , Runyu Miao , Xinyi Fang , Ruiyang Yin , Huifang Guan , Jiaxing Tian

Extensive case-control association studies have been conducted over the past few decades to investigate the relationship between MTHFR polymorphism and type 2 diabetes mellitus (T2DM) microangiopathy. However, the strength of the evidence and clinical significance are unclear. Consequently, a meta-analysis was performed to examine the correlations between two prevalent MTHFR single nucleotide polymorphisms, MTHFR C677T and A1298C, and T2DM microangiopathy. Randomized controlled trials were systematically searched in PubMed, Cochrane, Embase, Web of Science, CNKI, VIP database, China Biology Medicine, and Wanfang until August 2023. A total of 42 studies were included. Random-effect models were utilized to estimate odds ratios (ORs) with 95% confidence intervals (CIs) to assess the association between MTHFR polymorphisms and T2DM microangiopathy susceptibility. T2DM microangiopathy was significantly associated with the MTHFR C677T polymorphism in the overall population (T vs C, OR = 1.43, 95% CI = 1.25-1.64; TT + CT vs CC: OR = 1.56, 95% CI = 1.30-1.88; TT vs CT + CC: OR = 1.66, 95% CI = 1.38-1.99; TT vs CC: OR = 2.03, 95% CI = 1.58-2.60). Additionally, the dominant model revealed that the MTHFR A1298C polymorphism was associated with T2DM microangiopathy (OR = 1.27, 95% CI: 1.09-1.47). This meta-analysis revealed that MTHFR may be involved in the pathogenesis of T2DM microangiopathy, providing a reference for early diagnosis and treatment of T2DM.

在过去的几十年中，已经开展了大量的病例对照关联研究，探讨 MTHFR 多态性与 2 型糖尿病（T2DM）微血管病变之间的关系。然而，证据的强度和临床意义尚不明确。因此，我们进行了一项荟萃分析，研究两种流行的 MTHFR 单核苷酸多态性（MTHFR C677T 和 A1298C）与 T2DM 微血管病变之间的相关性。截至 2023 年 8 月，在 PubMed、Cochrane、Embase、Web of Science、CNKI、VIP 数据库、中国生物医学和万方数据库中系统检索了随机对照试验。共纳入 42 项研究。研究采用随机效应模型估算几率比（ORs）和 95% 置信区间（CIs），以评估 MTHFR 多态性与 T2DM 微血管病变易感性之间的关系。在总体人群中，T2DM 微血管病与 MTHFR C677T 多态性显著相关（T vs C：OR = 1.43，95% CI = 1.25-1.64；TT + CT vs CC：OR = 1.56，95% CI = 1.30-1.88；TT vs CT + CC：OR = 1.66，95% CI = 1.38-1.99；TT vs CC：OR = 2.03，95% CI = 1.58-2.60）。此外，显性模型显示，MTHFR A1298C 多态性与 T2DM 微血管病变相关（OR = 1.27，95% CI：1.09-1.47）。这项荟萃分析表明，MTHFR可能参与了T2DM微血管病变的发病机制，为T2DM的早期诊断和治疗提供了参考。

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引用次数: 0

A higher dietary alpha-linolenic acid intake is associated with lower colorectal cancer risk based on MUC4 rs2246901 variant among Korean adults 基于韩国成年人 MUC4 rs2246901 变异，膳食中α-亚麻酸摄入量越高，患结直肠癌的风险越低。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research

Pub Date : 2024-09-07 DOI: 10.1016/j.nutres.2024.09.003

Ha Thi Mien Nguyen , Madhawa Gunathilake , Jeonghee Lee , Jae Hwan Oh , Hee Jin Chang , Dae Kyung Sohn , Aesun Shin , Jeongseon Kim

Alpha-linolenic acid (C18:3n-3 [ALA]) intake may have a beneficial effect in reducing cancer risk; however, its association with colorectal cancer (CRC) risk remains conflicted. Additionally, ALA was emphasized as being associated with mucins, an important glycoproteins family within the intestine. Thus, we hypothesized that a higher dietary ALA intake may reduce the risk of CRC and this preventive effect has an interaction with mucin 4 (MUC4) rs2246901. We conducted a case-control study at the National Cancer Center in Korea, involving 1039 cases and 1982 controls, aiming to determine the interaction of the MUC4 rs2246901 polymorphism and ALA intake in CRC risk. Dietary ALA intake was collected via semiquantitative food frequency questionnaire (SQFFQ), categorizing by 4 quartiles. We evaluated the odds ratios (ORs) and 95% confidence intervals (CIs) through unconditional logistic regression models. Higher dietary ALA intake was found to be inversely associated with CRC risk (adjusted OR = 0.58; 95% CI, 0.45–0.75, P for trend < .001). No significant association between MUC4 rs2246901 polymorphism and CRC risk was found. In a recessive model, MUC4 rs2246901 seemed to modify this association; participants with at least 1 major allele and higher ALA intake had a significantly lower CRC risk than those who had a lower intake (adjusted OR = 0.56; 95% CI, 0.43–0.72; P interaction = .047). A higher dietary ALA was proposed as a potential protective nutrient against CRC. Moreover, this association might be influenced by presence of the MUC4 rs2246901 polymorphism.

α-亚麻酸（C18:3n-3 [ALA]）的摄入量可能对降低癌症风险有益；但是，它与结直肠癌（CRC）风险的关系仍然存在矛盾。此外，ALA 被强调与粘蛋白有关，而粘蛋白是肠道内重要的糖蛋白家族。因此，我们假设，从膳食中摄入更多的 ALA 可降低患 CRC 的风险，而这种预防效果与粘蛋白 4 (MUC4) rs2246901 有相互作用。我们在韩国国立癌症中心进行了一项病例对照研究，涉及 1039 例病例和 1982 例对照，旨在确定 MUC4 rs2246901 多态性与 ALA 摄入量在 CRC 风险中的相互作用。膳食中的 ALA 摄入量是通过半定量食物频率问卷（SQFFQ）收集的，分为 4 个四分位数。我们通过无条件逻辑回归模型评估了几率比（ORs）和95%置信区间（CIs）。结果发现，膳食中ALA的摄入量越高，患CRC的风险越低（调整OR = 0.58；95% CI，0.45-0.75，趋势P < .001）。未发现 MUC4 rs2246901 多态性与 CRC 风险有明显关联。在隐性模型中，MUC4 rs2246901 似乎改变了这种关联；至少有一个主要等位基因且 ALA 摄入量较高的参与者的 CRC 风险明显低于 ALA 摄入量较低者（调整 OR = 0.56；95% CI，0.43-0.72；P 交互作用 = .047）。膳食中较多的 ALA 被认为是一种潜在的保护性营养素，可预防 CRC。此外，这种关联可能受到 MUC4 rs2246901 多态性的影响。

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引用次数: 0