首页 > 最新文献

Nutrition Research最新文献

英文 中文
Variants in GHRL, RETN, and PLIN1 are associated with obesity, diabetes, and metabolic syndrome, and influence food consumption in adults with obesity GHRL、RETN和PLIN1的变异与肥胖、糖尿病和代谢综合征有关,并影响肥胖成人的食物消耗。
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2024.12.005
Marina Aparecida dos Santos , Raul Hernandes Bortolin , Alvaro Cerda , Raquel de Oliveira , Tamires Invencioni Moraes Stefani , Cristina Moreno Fajardo , Egídio Lima Dorea , Márcia Martins Silveira Bernik , Nágila Raquel Teixeira Damasceno , Mario Hiroyuki Hirata , Rosario Dominguez Crespo Hirata
Genetic and environmental factors have important role in the pathogenesis of obesity and metabolic diseases. We hypothesized that genes involved in energy intake, cellular lipid metabolism and pro-inflammatory adipokines influence obesity-related metabolic disturbances and food intake. We explored the association of GHRL (rs26311G>C and rs4684677A>T), PLIN1 (rs2289487G>A and rs894160G>A), RETN (rs3745367C>T and rs7408174G>A), and NAMPT (rs1319501T>C) variants with obesity, metabolic and inflammatory markers, and food intake composition. Clinical, anthropometric, and laboratory data were obtained from 237 adults. Genomic DNA was extracted and genetic variants were analyzed by real-time polymerase chain reaction. Food intake was assessed in 81 subjects with obesity, who underwent a 9-week nutritional orientation program. Multivariate logistic regression analysis adjusted by covariates showed association of GHRL rs26311-G and rs4684677-A alleles with risk of type 2 diabetes (T2D) and/or metabolic syndrome (P < .05), and RETN rs7408174-C allele with risk of T2D and obesity (P < .05). Covariate-adjusted multivariate linear regression analysis showed association of PLIN1 rs894160-G allele with increased waist-to-hip ratio (P = .003). The nutritional orientation program reduced carbohydrate and total fat intake, in subjects with obesity (P < .05). Analysis of basal data revealed associations of PLIN1 rs894160-G with increased body mass index, PLIN1 rs2289487-A with reduced intake of total fat, monosaturated fatty acids and cholesterol, and RETN rs3745367-A with increased intake of protein and saturated fatty acids (P < .05). GHRL rs26311-G was associated with increased postprogram protein intake (P = .044). In conclusion, variants in GHRL, RETN, and PLIN1 are associated with obesity, T2D, metabolic syndrome, and increased waist-to-hip ratio, and influence food consumption in adults with obesity.
遗传和环境因素在肥胖和代谢性疾病的发病机制中起着重要作用。我们假设参与能量摄入、细胞脂质代谢和促炎脂肪因子的基因影响肥胖相关的代谢紊乱和食物摄入。我们探讨了GHRL (rs26311G>C和rs4684677A>T)、PLIN1 (rs2289487G>A和rs894160G>A)、RETN (rs3745367C>T和rs7408174G>A)和NAMPT (rs1319501T>C)变异与肥胖、代谢和炎症标志物以及食物摄入组成的关系。临床、人体测量和实验室数据来自237名成年人。提取基因组DNA,实时聚合酶链反应分析遗传变异。81名肥胖患者接受了为期9周的营养指导计划,对他们的食物摄入量进行了评估。经协变量校正的多因素logistic回归分析显示,GHRL rs26111 - g和rs4684677-A等位基因与2型糖尿病(T2D)和/或代谢综合征的风险相关(P < 0.05), RETN rs7408174-C等位基因与T2D和肥胖的风险相关(P < 0.05)。协变量校正多因素线性回归分析显示,PLIN1 rs894160-G等位基因与腰臀比增加相关(P = 0.003)。营养导向方案减少了肥胖受试者的碳水化合物和总脂肪摄入量(P < 0.05)。基础数据分析显示,PLIN1 rs894160-G与体重指数增加有关,PLIN1 rs2289487-A与总脂肪、单饱和脂肪酸和胆固醇摄入量减少有关,RETN rs3745367-A与蛋白质和饱和脂肪酸摄入量增加有关(P < 0.05)。GHRL rs26311-G与项目后蛋白质摄入量增加相关(P = 0.044)。总之,GHRL、RETN和PLIN1的变异与肥胖、T2D、代谢综合征和腰臀比增加有关,并影响肥胖成人的食物消耗。
{"title":"Variants in GHRL, RETN, and PLIN1 are associated with obesity, diabetes, and metabolic syndrome, and influence food consumption in adults with obesity","authors":"Marina Aparecida dos Santos ,&nbsp;Raul Hernandes Bortolin ,&nbsp;Alvaro Cerda ,&nbsp;Raquel de Oliveira ,&nbsp;Tamires Invencioni Moraes Stefani ,&nbsp;Cristina Moreno Fajardo ,&nbsp;Egídio Lima Dorea ,&nbsp;Márcia Martins Silveira Bernik ,&nbsp;Nágila Raquel Teixeira Damasceno ,&nbsp;Mario Hiroyuki Hirata ,&nbsp;Rosario Dominguez Crespo Hirata","doi":"10.1016/j.nutres.2024.12.005","DOIUrl":"10.1016/j.nutres.2024.12.005","url":null,"abstract":"<div><div>Genetic and environmental factors have important role in the pathogenesis of obesity and metabolic diseases. We hypothesized that genes involved in energy intake, cellular lipid metabolism and pro-inflammatory adipokines influence obesity-related metabolic disturbances and food intake. We explored the association of <em>GHRL</em> (rs26311G&gt;C and rs4684677A&gt;T), <em>PLIN1</em> (rs2289487G&gt;A and rs894160G&gt;A), <em>RETN</em> (rs3745367C&gt;T and rs7408174G&gt;A), and <em>NAMPT</em> (rs1319501T&gt;C) variants with obesity, metabolic and inflammatory markers, and food intake composition. Clinical, anthropometric, and laboratory data were obtained from 237 adults. Genomic DNA was extracted and genetic variants were analyzed by real-time polymerase chain reaction. Food intake was assessed in 81 subjects with obesity, who underwent a 9-week nutritional orientation program. Multivariate logistic regression analysis adjusted by covariates showed association of <em>GHRL</em> rs26311-G and rs4684677-A alleles with risk of type 2 diabetes (T2D) and/or metabolic syndrome (<em>P</em> &lt; .05), and <em>RETN</em> rs7408174-C allele with risk of T2D and obesity (<em>P</em> &lt; .05). Covariate-adjusted multivariate linear regression analysis showed association of <em>PLIN1</em> rs894160-G allele with increased waist-to-hip ratio (<em>P</em> = .003). The nutritional orientation program reduced carbohydrate and total fat intake, in subjects with obesity (<em>P</em> &lt; .05). Analysis of basal data revealed associations of <em>PLIN1</em> rs894160-G with increased body mass index, <em>PLIN1</em> rs2289487-A with reduced intake of total fat, monosaturated fatty acids and cholesterol, and <em>RETN</em> rs3745367-A with increased intake of protein and saturated fatty acids (<em>P</em> &lt; .05). <em>GHRL</em> rs26311-G was associated with increased postprogram protein intake (<em>P</em> = .044). In conclusion, variants in <em>GHRL, RETN,</em> and <em>PLIN1</em> are associated with obesity, T2D, metabolic syndrome, and increased waist-to-hip ratio, and influence food consumption in adults with obesity.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 13-23"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
l-theanine: From tea leaf to trending supplement – does the science match the hype for brain health and relaxation?
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2024.12.008
Roderick Dashwood , Francesco Visioli
l-Theanine is a unique non-protein amino acid found abundantly in tea leaves. Interest in its potential use as a dietary supplement has surged recently, especially claims related to promoting relaxation and cognitive enhancement. This review surveys the chemistry, metabolism, and purported biological activities of l-theanine. It is well absorbed from the intestine and can cross the blood-brain barrier. Some studies suggest l-theanine may increase alpha waves in the brain associated with relaxation and selective attention, reduce stress and anxiety, and improve sleep quality, though findings are often inconsistent. Potential neuroprotective and anti-seizure effects have also been reported in animal models. When combined with caffeine, l-theanine may improve cognitive performance, alertness and focus. However, the evidence supporting many health claims remains limited, especially the lack of rigorous human clinical trials. While l-theanine exhibits a good safety profile based on toxicology studies, caution is warranted regarding the purported health benefits, until stronger scientific substantiation emerges. Overall, the mechanisms of action and therapeutic potential of l-theanine require further investigation, given the current interest and increasing popularity of this nutraceutical supplement marketed for brain health and relaxation. In the absence of well-designed and carefully controlled human clinical trials, we would urge caution in the use of l-theanine supplements at pharmacologic doses by the wider population, and believe that the science does not yet match the hype behind this trending supplement for brain health and relaxation.
{"title":"l-theanine: From tea leaf to trending supplement – does the science match the hype for brain health and relaxation?","authors":"Roderick Dashwood ,&nbsp;Francesco Visioli","doi":"10.1016/j.nutres.2024.12.008","DOIUrl":"10.1016/j.nutres.2024.12.008","url":null,"abstract":"<div><div><span>l</span>-Theanine is a unique non-protein amino acid found abundantly in tea leaves. Interest in its potential use as a dietary supplement has surged recently, especially claims related to promoting relaxation and cognitive enhancement. This review surveys the chemistry, metabolism, and purported biological activities of <span>l</span>-theanine. It is well absorbed from the intestine and can cross the blood-brain barrier. Some studies suggest <span>l</span>-theanine may increase alpha waves in the brain associated with relaxation and selective attention, reduce stress and anxiety, and improve sleep quality, though findings are often inconsistent. Potential neuroprotective and anti-seizure effects have also been reported in animal models. When combined with caffeine, <span>l</span>-theanine may improve cognitive performance, alertness and focus. However, the evidence supporting many health claims remains limited, especially the lack of rigorous human clinical trials. While <span>l</span>-theanine exhibits a good safety profile based on toxicology studies, caution is warranted regarding the purported health benefits, until stronger scientific substantiation emerges. Overall, the mechanisms of action and therapeutic potential of <span>l</span>-theanine require further investigation, given the current interest and increasing popularity of this nutraceutical supplement marketed for brain health and relaxation. In the absence of well-designed and carefully controlled human clinical trials, we would urge caution in the use of <span>l</span>-theanine supplements at pharmacologic doses by the wider population, and believe that the science does not yet match the hype behind this trending supplement for brain health and relaxation.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 39-48"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cashew nut consumption reduces waist circumference and oxidative stress in adolescents with obesity: A randomized clinical trial
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2024.12.009
Luis Felipe Nunes de Oliveira , Carla Soraya Costa Maia , Maria Dinara de Araújo Nogueira , Thaynan dos Santos Dias , Matheus Aragão Dias Firmino , Ana Paula de Melo Loureiro , Elisabete Leide Marzola , Paulo Iury Gomes Nunes , Flávia Almeida Santos , Walter Breno de Souza Freire , Rodrigo Soares Fortunato , Adriano César Carneiro Loureiro
Previous evidence suggests that certain types of nuts, when included in a healthy diet pattern, may provide health benefits. Therefore, we hypothesize that the consumption of cashew nuts associated with a healthy diet may enhance antioxidant defenses and improve anthropometric and body composition parameters in individuals with obesity. We conducted a 12-week randomized clinical trial, divided into 4 sessions, involving adolescents randomly assigned to receive either 30 g of roasted cashew nuts together with nutrition education (cashew nut group-CNG) or only nutrition education (control group-CG). The total number of participants who started the study was 142, with 77 in the CNG and 65 in the CG. Data on anthropometry, body composition, and oxidative stress were collected at baseline (0-week) and endpoint (12-week). The main post-intervention findings in the CNG showed decreases in waist circumference (WC), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) at 60 minutes in the CNG, while neck circumference (NC) increased. However, the CG showed an increase in TBARS and percentage of lean body mass (LBM), along with reduction in TAC at 60 minutes. After 12 weeks, the consumption of cashew nuts seemed to assist in WC reduction, even without a decrease in other anthropometric parameters, thereby decreasing the cardiometabolic risk. Furthermore, the consumption of cashew nuts demonstrated the ability to decrease overall oxidative damage as assessed by TBARS, a finding that reinforces the effects of this nut consumption against systemic oxidative stress associated with obesity.
{"title":"Cashew nut consumption reduces waist circumference and oxidative stress in adolescents with obesity: A randomized clinical trial","authors":"Luis Felipe Nunes de Oliveira ,&nbsp;Carla Soraya Costa Maia ,&nbsp;Maria Dinara de Araújo Nogueira ,&nbsp;Thaynan dos Santos Dias ,&nbsp;Matheus Aragão Dias Firmino ,&nbsp;Ana Paula de Melo Loureiro ,&nbsp;Elisabete Leide Marzola ,&nbsp;Paulo Iury Gomes Nunes ,&nbsp;Flávia Almeida Santos ,&nbsp;Walter Breno de Souza Freire ,&nbsp;Rodrigo Soares Fortunato ,&nbsp;Adriano César Carneiro Loureiro","doi":"10.1016/j.nutres.2024.12.009","DOIUrl":"10.1016/j.nutres.2024.12.009","url":null,"abstract":"<div><div>Previous evidence suggests that certain types of nuts, when included in a healthy diet pattern, may provide health benefits. Therefore, we hypothesize that the consumption of cashew nuts associated with a healthy diet may enhance antioxidant defenses and improve anthropometric and body composition parameters in individuals with obesity. We conducted a 12-week randomized clinical trial, divided into 4 sessions, involving adolescents randomly assigned to receive either 30 g of roasted cashew nuts together with nutrition education (cashew nut group-CNG) or only nutrition education (control group-CG). The total number of participants who started the study was 142, with 77 in the CNG and 65 in the CG. Data on anthropometry, body composition, and oxidative stress were collected at baseline (0-week) and endpoint (12-week). The main post-intervention findings in the CNG showed decreases in waist circumference (WC), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) at 60 minutes in the CNG, while neck circumference (NC) increased. However, the CG showed an increase in TBARS and percentage of lean body mass (LBM), along with reduction in TAC at 60 minutes. After 12 weeks, the consumption of cashew nuts seemed to assist in WC reduction, even without a decrease in other anthropometric parameters, thereby decreasing the cardiometabolic risk. Furthermore, the consumption of cashew nuts demonstrated the ability to decrease overall oxidative damage as assessed by TBARS, a finding that reinforces the effects of this nut consumption against systemic oxidative stress associated with obesity.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 60-72"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High air pollution exposure, vitamin D deficiency and ever smokers were associated with higher prevalence of hypercholesterolemia: A cross-sectional study from the 2008–2014 Korea National Health and Nutrition Examination Survey 2008-2014年韩国国家健康与营养检查调查的一项横断面研究表明,高空气污染暴露、维生素D缺乏和曾经吸烟者与高胆固醇血症的高发率有关。
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2024.12.002
Jung Hyun Kwak , Hyun Ja Kim
Air pollutants directly and indirectly cause vitamin D deficiency (VDD). In addition, smoking increases oxidative stress and accelerates skin aging, thereby reducing the body's vitamin D concentration. Previous study reported that VDD increases total cholesterol concentration by reducing vitamin D receptor activity. We hypothesized that high air pollution exposure, smoking, and VDD would increase hypercholesterolemia. We investigated associations between long-term exposure to air pollutants, smoking status, VDD, and their combination with hypercholesterolemia using data from the 2008-2014 Korea National Health and Nutrition Examination Survey (KNHANES). We used linked data from the KNHANES to the daily moving average of air-pollution data from 730 days before the examination date, using participants’ addresses in latitude and longitude coordinates. Results were analyzed using a survey logistic regression model for complex sample analyses. We included 28,134 adults with data on serum vitamin D, cholesterol concentrations, smoking status, and air pollutant concentrations. After adjusting for potential covariates, adults with exposure to high concentrations of air pollutants and ever smokers showed significantly higher risks of VDD (odds ratios [ORs], 1.70; 95 % confidence intervals [CIs], 1.44-2.00). In the group with high air-pollutant exposure, adults with low vitamin D status and ever smokers had significantly higher risks of hypercholesterolemia (ORs, 1.55; 95 % CIs, 1.09-2.19) than adults with high vitamin D status and never smokers. We found that high air-pollutant exposure, ever smokers, and VDD may increase hypercholesterolemia prevalence in Korean adults. Therefore, to reduce hypercholesterolemia risk, adults living in areas with high air-pollution exposure may need adequate vitamin D intake and to avoid smoking.
空气污染物直接或间接导致维生素D缺乏(VDD)。此外,吸烟会增加氧化应激,加速皮肤老化,从而降低体内维生素D的浓度。先前的研究报道,VDD通过降低维生素D受体活性来增加总胆固醇浓度。我们假设高空气污染暴露、吸烟和VDD会增加高胆固醇血症。我们使用2008-2014年韩国国家健康与营养调查(KNHANES)的数据调查了长期暴露于空气污染物、吸烟状况、VDD及其与高胆固醇血症的结合之间的关系。我们将KNHANES的数据与考试日期前730天的空气污染数据的日移动平均值相关联,使用参与者的纬度和经度坐标。结果分析采用调查逻辑回归模型进行复杂样本分析。我们纳入了28134名成年人的血清维生素D、胆固醇浓度、吸烟状况和空气污染物浓度数据。在调整了潜在的协变量后,暴露于高浓度空气污染物和曾经吸烟的成年人患VDD的风险明显更高(优势比[ORs], 1.70;95%置信区间[ci], 1.44-2.00)。在高空气污染物暴露组中,维生素D水平低和曾经吸烟的成年人患高胆固醇血症的风险明显更高(ORs, 1.55;95% ci(1.09-2.19)比维生素D含量高且从不吸烟的成年人高。我们发现高空气污染暴露、曾经吸烟和VDD可能会增加韩国成年人高胆固醇血症的患病率。因此,为了降低高胆固醇血症的风险,生活在高空气污染地区的成年人可能需要摄入足够的维生素D,并避免吸烟。
{"title":"High air pollution exposure, vitamin D deficiency and ever smokers were associated with higher prevalence of hypercholesterolemia: A cross-sectional study from the 2008–2014 Korea National Health and Nutrition Examination Survey","authors":"Jung Hyun Kwak ,&nbsp;Hyun Ja Kim","doi":"10.1016/j.nutres.2024.12.002","DOIUrl":"10.1016/j.nutres.2024.12.002","url":null,"abstract":"<div><div>Air pollutants directly and indirectly cause vitamin D deficiency (VDD). In addition, smoking increases oxidative stress and accelerates skin aging, thereby reducing the body's vitamin D concentration. Previous study reported that VDD increases total cholesterol concentration by reducing vitamin D receptor activity. We hypothesized that high air pollution exposure, smoking, and VDD would increase hypercholesterolemia. We investigated associations between long-term exposure to air pollutants, smoking status, VDD, and their combination with hypercholesterolemia using data from the 2008-2014 Korea National Health and Nutrition Examination Survey (KNHANES). We used linked data from the KNHANES to the daily moving average of air-pollution data from 730 days before the examination date, using participants’ addresses in latitude and longitude coordinates. Results were analyzed using a survey logistic regression model for complex sample analyses. We included 28,134 adults with data on serum vitamin D, cholesterol concentrations, smoking status, and air pollutant concentrations. After adjusting for potential covariates, adults with exposure to high concentrations of air pollutants and ever smokers showed significantly higher risks of VDD (odds ratios [ORs], 1.70; 95 % confidence intervals [CIs], 1.44-2.00). In the group with high air-pollutant exposure, adults with low vitamin D status and ever smokers had significantly higher risks of hypercholesterolemia (ORs, 1.55; 95 % CIs, 1.09-2.19) than adults with high vitamin D status and never smokers. We found that high air-pollutant exposure, ever smokers, and VDD may increase hypercholesterolemia prevalence in Korean adults. Therefore, to reduce hypercholesterolemia risk, adults living in areas with high air-pollution exposure may need adequate vitamin D intake and to avoid smoking.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 1-12"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low and high glycemic index drinks differentially affect sleep polysomnography and memory consolidation: A randomized controlled trial
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2024.11.012
Chantelle M. Gaylor , Anthony Brennan , Mark Blagrove , Chloe Tulip , Anthony Bloxham , Stevie Williams , Rory Tucker , David Benton , Hayley A. Young
Limited research has examined the effect of meal composition on sleep. Based on previous research, we hypothesized that a low glycemic index (LGI) drink containing 50 g isomaltulose (Palatinose, GI = 32) would result in more N3 sleep, less rapid eye movement (REM) sleep, and better memory consolidation than a high glycemic index (HGI) drink containing 50 g glucose (GI = 100). Healthy males (n = 20) attended the laboratory on three occasions at least a week apart (one acclimatization night and two test nights). Using a repeated measures, randomized, double-blind design, participants consumed a standardized evening meal followed four hours later by a HGI or LGI drink. Sleep architecture and continuity were assessed using polysomnography. Procedural and episodic memory were assessed pre- and post-sleep using a finger tapping task and story recall task, respectively. There was no main effect of drink. However, there was an interaction between drink and drink order. N3 sleep percentage was significantly longer (28.71% vs 23.99%, respectively, p = .032) and overnight retention of neutral story content was significantly better (0.63 words vs -10.13 words, respectively, p = .002) after the LGI drink than HGI drink, but only when the LGI drink was consumed on the second test night and HGI drink on the first test night. No changes in REM sleep were observed. Findings suggest that the nature of carbohydrate consumed before bed may influence sleep quality and quantity and neutral episodic memory consolidation. Pre-registered with ClinicalTrials.gov (NCT05591573).
{"title":"Low and high glycemic index drinks differentially affect sleep polysomnography and memory consolidation: A randomized controlled trial","authors":"Chantelle M. Gaylor ,&nbsp;Anthony Brennan ,&nbsp;Mark Blagrove ,&nbsp;Chloe Tulip ,&nbsp;Anthony Bloxham ,&nbsp;Stevie Williams ,&nbsp;Rory Tucker ,&nbsp;David Benton ,&nbsp;Hayley A. Young","doi":"10.1016/j.nutres.2024.11.012","DOIUrl":"10.1016/j.nutres.2024.11.012","url":null,"abstract":"<div><div>Limited research has examined the effect of meal composition on sleep. Based on previous research, we hypothesized that a low glycemic index (LGI) drink containing 50 g isomaltulose (Palatinose, GI = 32) would result in more N3 sleep, less rapid eye movement (REM) sleep, and better memory consolidation than a high glycemic index (HGI) drink containing 50 g glucose (GI = 100). Healthy males (n = 20) attended the laboratory on three occasions at least a week apart (one acclimatization night and two test nights). Using a repeated measures, randomized, double-blind design, participants consumed a standardized evening meal followed four hours later by a HGI or LGI drink. Sleep architecture and continuity were assessed using polysomnography. Procedural and episodic memory were assessed pre- and post-sleep using a finger tapping task and story recall task, respectively. There was no main effect of drink. However, there was an interaction between drink and drink order. N3 sleep percentage was significantly longer (28.71% vs 23.99%, respectively, <em>p</em> = .032) and overnight retention of neutral story content was significantly better (0.63 words vs -10.13 words, respectively, <em>p</em> = .002) after the LGI drink than HGI drink, but only when the LGI drink was consumed on the second test night and HGI drink on the first test night. No changes in REM sleep were observed. Findings suggest that the nature of carbohydrate consumed before bed may influence sleep quality and quantity and neutral episodic memory consolidation. Pre-registered with ClinicalTrials.gov (NCT05591573).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 49-59"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalized nutrition studies of human gut microbiome-polyphenol interactions utilizing continuous multistaged in vitro fermentation models–a narrative review
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-01-31 DOI: 10.1016/j.nutres.2025.01.011
Shiqi Zhang , Hanmeng Niu , Jiangjiang Zhu
The gut microbiota, a complex community of microorganisms primarily inhabiting the human large intestine, plays a crucial role in human health. Gut dysbiosis, characterized by an imbalance in gut bacterial populations, has been increasingly recognized as a significant factor in the pathogenesis of metabolic diseases such as type 2 diabetes, inflammatory bowel disease, and colorectal cancer. Polyphenols are critical modulators of gut microbial composition and metabolism. However, the extent of polyphenol-induced modulation of the gut microbiome remains largely unexplored. In vitro models offer a convenient and ethical alternative to in vivo studies for investigating nutrient-gut microbiome interactions, facilitating easy sampling and controlled experimental conditions. Among these, continuous multistaged in vitro fermentation models, which simulate different sections of the human gastrointestinal tract (e.g., proximal colon, transverse colon, and distal colon), provide a more accurate representation of the human gut environment compared to single-batch fermentation. Various configurations of these multistaged models have been developed and widely employed in studies examining the effects of polyphenols on the gut microbiome. This review aims to summarize the different configurations of multistaged in vitro fermentation models and recent advancements in their development, highlight key aspects of experimental design, outline commonly used analytical workflows with complementary analyses, and review the restorative effects of polyphenol interventions on dysregulated gut microbiota.
{"title":"Personalized nutrition studies of human gut microbiome-polyphenol interactions utilizing continuous multistaged in vitro fermentation models–a narrative review","authors":"Shiqi Zhang ,&nbsp;Hanmeng Niu ,&nbsp;Jiangjiang Zhu","doi":"10.1016/j.nutres.2025.01.011","DOIUrl":"10.1016/j.nutres.2025.01.011","url":null,"abstract":"<div><div>The gut microbiota, a complex community of microorganisms primarily inhabiting the human large intestine, plays a crucial role in human health. Gut dysbiosis, characterized by an imbalance in gut bacterial populations, has been increasingly recognized as a significant factor in the pathogenesis of metabolic diseases such as type 2 diabetes, inflammatory bowel disease, and colorectal cancer. Polyphenols are critical modulators of gut microbial composition and metabolism. However, the extent of polyphenol-induced modulation of the gut microbiome remains largely unexplored. <em>In vitro</em> models offer a convenient and ethical alternative to <em>in vivo</em> studies for investigating nutrient-gut microbiome interactions, facilitating easy sampling and controlled experimental conditions. Among these, continuous multistaged <em>in vitro</em> fermentation models, which simulate different sections of the human gastrointestinal tract (e.g., proximal colon, transverse colon, and distal colon), provide a more accurate representation of the human gut environment compared to single-batch fermentation. Various configurations of these multistaged models have been developed and widely employed in studies examining the effects of polyphenols on the gut microbiome. This review aims to summarize the different configurations of multistaged <em>in vitro</em> fermentation models and recent advancements in their development, highlight key aspects of experimental design, outline commonly used analytical workflows with complementary analyses, and review the restorative effects of polyphenol interventions on dysregulated gut microbiota.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 101-127"},"PeriodicalIF":3.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study protocol, menu design, and rationale for a study testing the effects of a whole fruit-rich diet on glycemic control, liver fat, pancreatic fat, and cardiovascular health in adults with type 2 diabetes
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-01-27 DOI: 10.1016/j.nutres.2025.01.008
Cody J. Hanick , Kelly J. Berg , W. Timothy Garvey , Amy M. Goss , Felicia L. Steger , Joshua S. Richman , Courtney M. Peterson
Dietary interventions such as very-low-calorie diets and low-carbohydrate diets can improve glycemic control and even induce type 2 diabetes (T2D) remission. However, less is known about the effects of carbohydrate-rich whole foods, such as whole fruit, in people with T2D. Therefore, the aim of this pilot study is to investigate the effects of a whole fruit-rich diet on glycemic control, ectopic fat, and cardiovascular risk factors in adults with T2D. In this pilot study, sixteen adults aged 20 to 70 years with insulin-independent T2D for ≤6 years will complete a 12-week controlled-feeding intervention while maintaining their weight. During the ramp-up phase (weeks 1-4), participants progressively consume more whole fruit. During weeks 5 to 12, participants eat a fruit-rich Mediterranean diet providing 50% of calories as whole fruit (∼16.4 servings/day). All outcomes are measured at weeks 0, 4, and 12. The primary outcome is glycemic control, assessed hierarchically by whether participants achieve nondiabetic glucose concentrations without antihyperglycemic medications; the total dose of antihyperglycemic medications; mean glucose during a three-hour oral glucose tolerance test; and mean 24-hour glucose from continuous glucose monitoring. Secondary outcomes include intrahepatic lipid, pancreatic fat, blood pressure, heart rate, and serum lipids. We hypothesize that a fruit-rich diet will improve glycemic control, reduce the need for antihyperglycemic medications, decrease ectopic fat, and improve cardiovascular risk factors. This novel study will help determine the effects of a whole fruit-rich diet on glycemic control and liver fat and whether diabetes remission may be possible without losing weight. This study was registered at ClinicalTrials.gov (NCT03758742).
{"title":"Study protocol, menu design, and rationale for a study testing the effects of a whole fruit-rich diet on glycemic control, liver fat, pancreatic fat, and cardiovascular health in adults with type 2 diabetes","authors":"Cody J. Hanick ,&nbsp;Kelly J. Berg ,&nbsp;W. Timothy Garvey ,&nbsp;Amy M. Goss ,&nbsp;Felicia L. Steger ,&nbsp;Joshua S. Richman ,&nbsp;Courtney M. Peterson","doi":"10.1016/j.nutres.2025.01.008","DOIUrl":"10.1016/j.nutres.2025.01.008","url":null,"abstract":"<div><div>Dietary interventions such as very-low-calorie diets and low-carbohydrate diets can improve glycemic control and even induce type 2 diabetes (T2D) remission. However, less is known about the effects of carbohydrate-rich whole foods, such as whole fruit, in people with T2D. Therefore, the aim of this pilot study is to investigate the effects of a whole fruit-rich diet on glycemic control, ectopic fat, and cardiovascular risk factors in adults with T2D. In this pilot study, sixteen adults aged 20 to 70 years with insulin-independent T2D for ≤6 years will complete a 12-week controlled-feeding intervention while maintaining their weight. During the ramp-up phase (weeks 1-4), participants progressively consume more whole fruit. During weeks 5 to 12, participants eat a fruit-rich Mediterranean diet providing 50% of calories as whole fruit (∼16.4 servings/day). All outcomes are measured at weeks 0, 4, and 12. The primary outcome is glycemic control, assessed hierarchically by whether participants achieve nondiabetic glucose concentrations without antihyperglycemic medications; the total dose of antihyperglycemic medications; mean glucose during a three-hour oral glucose tolerance test; and mean 24-hour glucose from continuous glucose monitoring. Secondary outcomes include intrahepatic lipid, pancreatic fat, blood pressure, heart rate, and serum lipids. We hypothesize that a fruit-rich diet will improve glycemic control, reduce the need for antihyperglycemic medications, decrease ectopic fat, and improve cardiovascular risk factors. This novel study will help determine the effects of a whole fruit-rich diet on glycemic control and liver fat and whether diabetes remission may be possible without losing weight. This study was registered at ClinicalTrials.gov (NCT03758742).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 82-100"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary inflammatory index predicts cancer mortality in male patients but not female patients: Results from NHANES 1999 to 2014
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-01-22 DOI: 10.1016/j.nutres.2025.01.007
Junyi Shen , Anqi Lin , Aimin Jiang , Zhenyu Xie , Quan Cheng , Jing Zhang , Jian Zhang , Peng Luo
This study explored sex differences between dietary inflammatory index (DII) and cancer prognosis and their mechanisms. We hypothesized that association between dietary inflammatory index and cancer prognosis differs by sex. The study included 2874 adults with cancer from the National Health and Nutrition Examination Survey covering 1999 to 2014. Mortality status was linked to National Death Index mortality data through 31 December 2019. Cox proportional hazards regression models were applied to calculate hazard risk and 95% confidence intervals (Cis) in male patients and female patients. Sex-specific cancer and nonsex-specific cancer subgroup analyses were performed, and the role of C-reactive protein in sex differences was analyzed. The Cancer Genome Atlas pan-cancer transcriptome data were combined to explore the biological mechanisms of the sex differences. Multivariate Cox regression showed higher DII in male patients correlated with increased all-cause mortality (hazard risk highest vs lowest quartile = 1.57 [95% confidence intervals 1.24-1.98]; P for trend <.01), but not in female patients (P = .44). For sex-specific cancers, higher DII potentially correlated with increased mortality in prostate cancer (unadjusted P for trend = .04), but not in breast (P = .83), ovarian (P = .49), or cervical cancers (P = .91). In melanoma and colon cancer, higher DII correlated with increased mortality in male patients but not female patients. Serum C-reactive protein, interleukin-1 binding, interleukin-35 pathway, and programmed cell death protein 1 pathway may contribute to these sex differences. In conclusion, sex differences exist between DII and mortality risk in cancer patients.
{"title":"Dietary inflammatory index predicts cancer mortality in male patients but not female patients: Results from NHANES 1999 to 2014","authors":"Junyi Shen ,&nbsp;Anqi Lin ,&nbsp;Aimin Jiang ,&nbsp;Zhenyu Xie ,&nbsp;Quan Cheng ,&nbsp;Jing Zhang ,&nbsp;Jian Zhang ,&nbsp;Peng Luo","doi":"10.1016/j.nutres.2025.01.007","DOIUrl":"10.1016/j.nutres.2025.01.007","url":null,"abstract":"<div><div>This study explored sex differences between dietary inflammatory index (DII) and cancer prognosis and their mechanisms. We hypothesized that association between dietary inflammatory index and cancer prognosis differs by sex. The study included 2874 adults with cancer from the National Health and Nutrition Examination Survey covering 1999 to 2014. Mortality status was linked to National Death Index mortality data through 31 December 2019. Cox proportional hazards regression models were applied to calculate hazard risk and 95% confidence intervals (Cis) in male patients and female patients. Sex-specific cancer and nonsex-specific cancer subgroup analyses were performed, and the role of C-reactive protein in sex differences was analyzed. The Cancer Genome Atlas pan-cancer transcriptome data were combined to explore the biological mechanisms of the sex differences. Multivariate Cox regression showed higher DII in male patients correlated with increased all-cause mortality (hazard risk highest vs lowest quartile = 1.57 [95% confidence intervals 1.24-1.98]; <em>P</em> for trend &lt;.01), but not in female patients (<em>P</em> = .44). For sex-specific cancers, higher DII potentially correlated with increased mortality in prostate cancer (unadjusted <em>P</em> for trend = .04), but not in breast (<em>P</em> = .83), ovarian (<em>P</em> = .49), or cervical cancers (<em>P</em> = .91). In melanoma and colon cancer, higher DII correlated with increased mortality in male patients but not female patients. Serum C-reactive protein, interleukin-1 binding, interleukin-35 pathway, and programmed cell death protein 1 pathway may contribute to these sex differences. In conclusion, sex differences exist between DII and mortality risk in cancer patients.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 52-66"},"PeriodicalIF":3.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-01-14 DOI: 10.1016/j.nutres.2025.01.006
Hend Al-Jaber , Rim Bacha , Wafaa A. Al-Mannai , Layla Al-Mansoori
Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, breast milk contains bioactive extracellular vesicles (BMEVs). These membrane-bound particles, rich in proteins, lipids, and nucleic acids, play a pivotal role in immune modulation, intercellular communication, and the overall development of the infant's immune system. This review explores the emerging therapeutic potential of BMEVs, highlighting their capacity to modulate recipient cell functions, influence immune responses, and contribute to overall infant health. Preclinical evidence suggests that these vesicles can prevent and manage conditions such as necrotizing enterocolitis, allergies, and viral infections, which are common in early childhood. Furthermore, BMEVs offer promise as vehicles for targeted drug delivery, enhancing the efficacy of therapeutic interventions. Despite the growing body of evidence, challenges such as the need for standardized isolation methods, characterization techniques, and larger-scale clinical studies persist, hindering the translation of this research into clinical practice. This review addresses these challenges and discusses future directions, emphasizing the need for comprehensive mechanistic studies to fully realize the potential of BMEVs as novel therapeutic agents and biomarkers of health. Ultimately, these vesicles represent a promising frontier in maternal and child health, with potential applications extending far beyond traditional nutrition. By harnessing their unique properties, BMEVs could revolutionize infant care, offering new strategies for disease prevention and innovative therapeutic interventions that enhance infant health outcomes.
{"title":"Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles","authors":"Hend Al-Jaber ,&nbsp;Rim Bacha ,&nbsp;Wafaa A. Al-Mannai ,&nbsp;Layla Al-Mansoori","doi":"10.1016/j.nutres.2025.01.006","DOIUrl":"10.1016/j.nutres.2025.01.006","url":null,"abstract":"<div><div>Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, breast milk contains bioactive extracellular vesicles (BMEVs). These membrane-bound particles, rich in proteins, lipids, and nucleic acids, play a pivotal role in immune modulation, intercellular communication, and the overall development of the infant's immune system. This review explores the emerging therapeutic potential of BMEVs, highlighting their capacity to modulate recipient cell functions, influence immune responses, and contribute to overall infant health. Preclinical evidence suggests that these vesicles can prevent and manage conditions such as necrotizing enterocolitis, allergies, and viral infections, which are common in early childhood. Furthermore, BMEVs offer promise as vehicles for targeted drug delivery, enhancing the efficacy of therapeutic interventions. Despite the growing body of evidence, challenges such as the need for standardized isolation methods, characterization techniques, and larger-scale clinical studies persist, hindering the translation of this research into clinical practice. This review addresses these challenges and discusses future directions, emphasizing the need for comprehensive mechanistic studies to fully realize the potential of BMEVs as novel therapeutic agents and biomarkers of health. Ultimately, these vesicles represent a promising frontier in maternal and child health, with potential applications extending far beyond traditional nutrition. By harnessing their unique properties, BMEVs could revolutionize infant care, offering new strategies for disease prevention and innovative therapeutic interventions that enhance infant health outcomes.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 42-51"},"PeriodicalIF":3.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the link between magnesium and diabetic neuropathy: Evidence from in vitro to clinical studies
IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-01-10 DOI: 10.1016/j.nutres.2025.01.005
Kannika Smithiseth , Prangmalee Leurcharusmee , Passakorn Sawaddiruk , Nipon Chattipakorn , Siriporn Chattipakorn
Diabetic neuropathy (DN) is one of the major complications of diabetes and the most common cause of neuropathic pain. Although the underlying pathological mechanisms remain unclear, several studies have produced conflicting results regarding the link between magnesium (Mg) concentration and DN. This ambiguity raises questions about the potential benefits of Mg supplementation in individuals with DN. Therefore, this comprehensive review summarizes and discusses the evidence from clinical, in vitro, and in vivo studies on the association between Mg and DN. Several findings indicate that Mg depletion is linked to the presence of neuropathy in diabetic patients. Additionally, low Mg concentration may contribute to the onset or worsening of DN by promoting axonal degeneration through various pathways. Furthermore, multiple studies have shown that Mg supplementation can have neuroprotective effects. These findings suggest potential as an alternative or complementary therapy for preventing and treating DN in the future.
{"title":"Unraveling the link between magnesium and diabetic neuropathy: Evidence from in vitro to clinical studies","authors":"Kannika Smithiseth ,&nbsp;Prangmalee Leurcharusmee ,&nbsp;Passakorn Sawaddiruk ,&nbsp;Nipon Chattipakorn ,&nbsp;Siriporn Chattipakorn","doi":"10.1016/j.nutres.2025.01.005","DOIUrl":"10.1016/j.nutres.2025.01.005","url":null,"abstract":"<div><div>Diabetic neuropathy (DN) is one of the major complications of diabetes and the most common cause of neuropathic pain. Although the underlying pathological mechanisms remain unclear, several studies have produced conflicting results regarding the link between magnesium (Mg) concentration and DN. This ambiguity raises questions about the potential benefits of Mg supplementation in individuals with DN. Therefore, this comprehensive review summarizes and discusses the evidence from clinical, <em>in vitro</em>, and <em>in vivo</em> studies on the association between Mg and DN. Several findings indicate that Mg depletion is linked to the presence of neuropathy in diabetic patients. Additionally, low Mg concentration may contribute to the onset or worsening of DN by promoting axonal degeneration through various pathways. Furthermore, multiple studies have shown that Mg supplementation can have neuroprotective effects. These findings suggest potential as an alternative or complementary therapy for preventing and treating DN in the future.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 13-31"},"PeriodicalIF":3.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Nutrition Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1