The Maternal Near miss (MNM) concept has led to a more comprehensive and better assessment of the effect of care on maternal health. Investigating severe life-threatening pregnancy complications that women encounter and maternal morbidities (near misses) may help evaluate the quality of care in health facilities and recommend ways to improve maternal survival, especially in poor resource settings. Aim This study aimed to identify causes, classify, and determine the nature of complications in maternal near misses and in maternal death. Material and Methods The hospital-based prospective cohort study was conducted in the Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Aligarh Muslim University of Aligarh from 2020 to 2022. The study was approved by the Institutional Ethics Committee and informed written consent was obtained from the study participants. The outcome measures included causes, organ dysfunction, complications, maternal morbidities, and neonatal outcome. Results: Higher rate of unbooked referrals was observed in our study. Hemorrhage was 42.9%, followed by 39.1% hypertensive disorders, 8.6% sepsis in the maternal near miss group while in the maternal mortality group, 26.1% had hypertensive disorders followed by 23.8% women had hemorrhagic disorders, and 20.4% had sepsis. There was a significant difference in HDU, ICU Hospital stay and IUDs in the maternal mortality group compared to the maternal near-miss group. Conclusion The WHO near-miss approach was found to represent a feasible strategy in low-resource settings each Near Miss should be evaluated in detail to diagnose underlying pathology, correct and timely detection of complications, prompt referral and early institution of essential and comprehensive obstetrics care are important for maternal and infant survival.
{"title":"Comparison of Causes of Maternal Near Miss and Maternal Mortality in a Tertiary Care Hospital: A Prospective Study","authors":"Nasreen Noor","doi":"10.31579/2578-8965/170","DOIUrl":"https://doi.org/10.31579/2578-8965/170","url":null,"abstract":"The Maternal Near miss (MNM) concept has led to a more comprehensive and better assessment of the effect of care on maternal health. Investigating severe life-threatening pregnancy complications that women encounter and maternal morbidities (near misses) may help evaluate the quality of care in health facilities and recommend ways to improve maternal survival, especially in poor resource settings. Aim This study aimed to identify causes, classify, and determine the nature of complications in maternal near misses and in maternal death. Material and Methods The hospital-based prospective cohort study was conducted in the Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Aligarh Muslim University of Aligarh from 2020 to 2022. The study was approved by the Institutional Ethics Committee and informed written consent was obtained from the study participants. The outcome measures included causes, organ dysfunction, complications, maternal morbidities, and neonatal outcome. Results: Higher rate of unbooked referrals was observed in our study. Hemorrhage was 42.9%, followed by 39.1% hypertensive disorders, 8.6% sepsis in the maternal near miss group while in the maternal mortality group, 26.1% had hypertensive disorders followed by 23.8% women had hemorrhagic disorders, and 20.4% had sepsis. There was a significant difference in HDU, ICU Hospital stay and IUDs in the maternal mortality group compared to the maternal near-miss group. Conclusion The WHO near-miss approach was found to represent a feasible strategy in low-resource settings each Near Miss should be evaluated in detail to diagnose underlying pathology, correct and timely detection of complications, prompt referral and early institution of essential and comprehensive obstetrics care are important for maternal and infant survival.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Ethiopian health care guidelines did not include antenatal perceived stress as a component of routine antenatal care, and this results in under-diagnosis of antenatal perceived stress during routine antenatal care follow-up. As a result, the purpose of this study to assess the prevalence of perceived stress and associated factors among pregnant women in the western Ethiopia. Methods: A community-based cross-sectional study was conducted among 451 pregnant women in West Shewa Zone, Oromia Region, Ethiopia. From September 20, 2021, to October 19, 2021, Pregnant women were recruited using cluster sampling techniques. Data was collected by using a standardized questionnaire that had been pre-tested. The data were entered into Epi data version 4.6 and then exported to SPSS version 26. Bivariate and multivariate logistic regression analyses were used to identify significantly associated factors. Result: The prevalence of perceived stress during pregnancy was 21.2% at 95% CI (20.1,23). Unplanned pregnancies (AOR: 5.43; CI 2.61-10.77), early ANC booking (AOR: 3.02 CI; 1.66-5.48) and obstetric complications during the current and previous pregnancies (AOR: 3.53CI; 1.9- 6.56) were significantly associated with perceived stress. Conclusion: The prevalence of perceived stress during pregnancy was higher, indicating a need to screen perceived stress and its predictors in routine antenatal care. Strengthening the counseling service and increasing access and availability of modern contraceptive methods may reduce the rates of unplanned pregnancies. This, in turn, plays a significant role in alleviating perceived stress in Ethiopia.
{"title":"Perceived Stress and Associated Factors Among Pregnant Women in Western Ethiopia: Community Based Cross-Sectional Study, 2021","authors":"Wogene Daro Kabale","doi":"10.31579/2578-8965/167","DOIUrl":"https://doi.org/10.31579/2578-8965/167","url":null,"abstract":"Background: Ethiopian health care guidelines did not include antenatal perceived stress as a component of routine antenatal care, and this results in under-diagnosis of antenatal perceived stress during routine antenatal care follow-up. As a result, the purpose of this study to assess the prevalence of perceived stress and associated factors among pregnant women in the western Ethiopia. Methods: A community-based cross-sectional study was conducted among 451 pregnant women in West Shewa Zone, Oromia Region, Ethiopia. From September 20, 2021, to October 19, 2021, Pregnant women were recruited using cluster sampling techniques. Data was collected by using a standardized questionnaire that had been pre-tested. The data were entered into Epi data version 4.6 and then exported to SPSS version 26. Bivariate and multivariate logistic regression analyses were used to identify significantly associated factors. Result: The prevalence of perceived stress during pregnancy was 21.2% at 95% CI (20.1,23). Unplanned pregnancies (AOR: 5.43; CI 2.61-10.77), early ANC booking (AOR: 3.02 CI; 1.66-5.48) and obstetric complications during the current and previous pregnancies (AOR: 3.53CI; 1.9- 6.56) were significantly associated with perceived stress. Conclusion: The prevalence of perceived stress during pregnancy was higher, indicating a need to screen perceived stress and its predictors in routine antenatal care. Strengthening the counseling service and increasing access and availability of modern contraceptive methods may reduce the rates of unplanned pregnancies. This, in turn, plays a significant role in alleviating perceived stress in Ethiopia.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intrauterine growth restriction (IUGR) is a pathology of multifactorial causes and complex management for the obstetrician. For a fetus, not reaching its growth potential represents a significant increase in the risk of perinatal morbidity and mortality. Cases of IUGR were more frequent in patients between 20 and 34 years of age with associated pathologies such as hypertension (HTN), urinary tract infection (UTI) and preeclampsia. The most frequent route of birth was eutocic births since the caesarean sections performed were mostly by previous caesarean sections. Of a total of 1656 births in 2022, 88 were CIUR, six early and 82 late.
{"title":"Characterization of Intrauterine Growth Restriction in Pregnant Women Hospital Gynecology and Obstetrics America Arias Havana, Cuba 2022","authors":"Georgina Álvarez Medina","doi":"10.31579/2578-8965/169","DOIUrl":"https://doi.org/10.31579/2578-8965/169","url":null,"abstract":"Intrauterine growth restriction (IUGR) is a pathology of multifactorial causes and complex management for the obstetrician. For a fetus, not reaching its growth potential represents a significant increase in the risk of perinatal morbidity and mortality. Cases of IUGR were more frequent in patients between 20 and 34 years of age with associated pathologies such as hypertension (HTN), urinary tract infection (UTI) and preeclampsia. The most frequent route of birth was eutocic births since the caesarean sections performed were mostly by previous caesarean sections. Of a total of 1656 births in 2022, 88 were CIUR, six early and 82 late.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Gynecological examination was а nursing concern because the nurse is expected to be beside female pre, during, and post-gynecological-examination. Nurses had very important role in preparing women before an examination. Aim: This study was conducted to evaluate the effect of pre-gynecological-examination-counseling-session on relieving women’s pain, discomfort and enhancing their satisfaction, as well. Setting: The study was conducted at the gynecological clinic at Beni-Suef University Hospital. Subjects and methods:design: A quasi-experimental research design was utilized in this study (an intervention pre/post-test). Sampling: 60 women who were attended the previously mentioned study setting for the first time. Sample type: Α purposive sample. Tools: six tools of data collection were used. (I): Interviewing questionnaire; (II): Comfort and pain scale; (III): Visual analogue scale; (IV): Patients’ satisfaction questionnaire sheet; (V): Counseling interviewing sheet; (VI): An Instructional supportive brochure. Results: there was a marked improvement in knowledge of the studied sample about gynecological examination post-implementation of an instructional supportive guideline with a highly statistically significant difference (P<0.01) between pre and post-implementation of the instructional supportive guideline. There was a positive correlation between the level of pain of the studied sample and their discomfort, satisfaction, self-reported barriers during gynecological examination, and satisfaction level post gynecological examination. Conclusion: Counseling sessions regarding pre-gynecological examination had a positive effect on relieving women’s pain, discomfort and enhancing their satisfaction. Recommendation: Nurse administrators must be designed, and apply a monitoring system to certain that nurses are well competent during providing pre-gynecological examination counseling sessions.
{"title":"Effect of Counselling Sessions on Women’s Satisfaction during Gynecological Examination","authors":"Hanan Elzeblawy Hassan","doi":"10.31579/2578-8965/119","DOIUrl":"https://doi.org/10.31579/2578-8965/119","url":null,"abstract":"Background: Gynecological examination was а nursing concern because the nurse is expected to be beside female pre, during, and post-gynecological-examination. Nurses had very important role in preparing women before an examination. Aim: This study was conducted to evaluate the effect of pre-gynecological-examination-counseling-session on relieving women’s pain, discomfort and enhancing their satisfaction, as well. Setting: The study was conducted at the gynecological clinic at Beni-Suef University Hospital. Subjects and methods:design: A quasi-experimental research design was utilized in this study (an intervention pre/post-test). Sampling: 60 women who were attended the previously mentioned study setting for the first time. Sample type: Α purposive sample. Tools: six tools of data collection were used. (I): Interviewing questionnaire; (II): Comfort and pain scale; (III): Visual analogue scale; (IV): Patients’ satisfaction questionnaire sheet; (V): Counseling interviewing sheet; (VI): An Instructional supportive brochure. Results: there was a marked improvement in knowledge of the studied sample about gynecological examination post-implementation of an instructional supportive guideline with a highly statistically significant difference (P<0.01) between pre and post-implementation of the instructional supportive guideline. There was a positive correlation between the level of pain of the studied sample and their discomfort, satisfaction, self-reported barriers during gynecological examination, and satisfaction level post gynecological examination. Conclusion: Counseling sessions regarding pre-gynecological examination had a positive effect on relieving women’s pain, discomfort and enhancing their satisfaction. Recommendation: Nurse administrators must be designed, and apply a monitoring system to certain that nurses are well competent during providing pre-gynecological examination counseling sessions.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81570941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Infertility is defined as the inability to conceive within 12 months of regular unprotected intercourse for women under 35 years of age and affects approximately 15% of reproductive aged couples [1]. A diagnosis of infertility is often emotionally, physically, and financially devastating and many patients will seek fertility assistance with their obstetrician and gynecologist. While there may be underlying factors contributing to infertility that that require specific treatments (i.e. fibroids requiring myomectomies), there are also many patients that are unaware of how best to optimize conception timing. Counseling patients regarding the science of reproduction and adjusting at home practices may increase their chances for success.
{"title":"How to Optimize Conception: Timing is everything!","authors":"Laurie J. McKenzie","doi":"10.31579/2578-8965/117","DOIUrl":"https://doi.org/10.31579/2578-8965/117","url":null,"abstract":"Infertility is defined as the inability to conceive within 12 months of regular unprotected intercourse for women under 35 years of age and affects approximately 15% of reproductive aged couples [1]. A diagnosis of infertility is often emotionally, physically, and financially devastating and many patients will seek fertility assistance with their obstetrician and gynecologist. While there may be underlying factors contributing to infertility that that require specific treatments (i.e. fibroids requiring myomectomies), there are also many patients that are unaware of how best to optimize conception timing. Counseling patients regarding the science of reproduction and adjusting at home practices may increase their chances for success.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88746432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hysterectomy, one of the most common gynaecological surgeries performed around the world, has many techniques including abdominal, vaginal, laparoscopic and robotic. The Vaginal technique which was introduced and performed eras back has been less successful due to lack of experience and eagerness among gynaecologists because of a misconception that the abdominal route is safer and is easier. Aims and Objectives: Evaluation of most efficient and suitable route of hysterectomy.comparison between intraoperative and postoperative complications in non descent vaginal hysterectomy and abdominal hysterectomy. Materials and Methods: This retrospective study was conducted during the period from October 2020 to December 2021, it studied 60 women who underwent hysterectomy for benign uterine disorder at Khemchand Jain Hospital, Sagar, out of which 30 women underwent non descent vaginal hysterectomy and 30 women underwent total abdominal hysterectomy. Result: Baseline characteristics were similar between the two groups with no intraoperative complications in either. Regarding operation duration, intraoperative blood loss, post-operative pain, post-operative blood transfusion, mobilization in post-operative periods, post-operative wounds infection, febrile morbidity, duration of hospitality stay, P-value was significant in vaginal hysterectomy when compared to abdominal hysterectomy. Regarding post-operative systematic infection, P-value was not significant. None of the cases in the vaginal group were converted to abdominal route and none of the cases in the whole study group underwent relaparotomy. Conclusion: The study concludes that patients requiring hysterectomy for benign non prolapse cases may be given the option of vaginal hysterectomy because it has quicker recovery, shorter hospitalization, lesser operative and post-operative morbidity compared to abdominal route.
{"title":"Non-Descent Vaginal Hysterectomy (Ndvh): A Promising Surgical Technique in Benign Uterine Disorders","authors":"Ruby Reja","doi":"10.31579/2578-8965/123","DOIUrl":"https://doi.org/10.31579/2578-8965/123","url":null,"abstract":"Background: Hysterectomy, one of the most common gynaecological surgeries performed around the world, has many techniques including abdominal, vaginal, laparoscopic and robotic. The Vaginal technique which was introduced and performed eras back has been less successful due to lack of experience and eagerness among gynaecologists because of a misconception that the abdominal route is safer and is easier. Aims and Objectives: Evaluation of most efficient and suitable route of hysterectomy.comparison between intraoperative and postoperative complications in non descent vaginal hysterectomy and abdominal hysterectomy. Materials and Methods: This retrospective study was conducted during the period from October 2020 to December 2021, it studied 60 women who underwent hysterectomy for benign uterine disorder at Khemchand Jain Hospital, Sagar, out of which 30 women underwent non descent vaginal hysterectomy and 30 women underwent total abdominal hysterectomy. Result: Baseline characteristics were similar between the two groups with no intraoperative complications in either. Regarding operation duration, intraoperative blood loss, post-operative pain, post-operative blood transfusion, mobilization in post-operative periods, post-operative wounds infection, febrile morbidity, duration of hospitality stay, P-value was significant in vaginal hysterectomy when compared to abdominal hysterectomy. Regarding post-operative systematic infection, P-value was not significant. None of the cases in the vaginal group were converted to abdominal route and none of the cases in the whole study group underwent relaparotomy. Conclusion: The study concludes that patients requiring hysterectomy for benign non prolapse cases may be given the option of vaginal hysterectomy because it has quicker recovery, shorter hospitalization, lesser operative and post-operative morbidity compared to abdominal route.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89165945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preeclampsia, one of the unique diseases of pregnancy, is a systemic vascular disease induced by various factors. Its main feature is that new-onset hypertension and proteinuria will appear after 20 weeks of pregnancy. Preeclampsia is the main cause of morbidity and mortality in pregnant women and perinatal babies. Many clinical and experimental studies have shownthat the pathological basis of preeclampsia is maternal endothelial dysfunction caused by placental factors. Moreover, it has been determined that the increase in placental anti-angiogenic factors is the main cause of vascular endothelial dysfunction and systemic vascular dysfunction in pregnant women. This review summarizes the latest advancesin the molecular mechanisms of endothelial dysfunction caused by placental anti-angiogenic factors and new clinical strategies based on these findings.
{"title":"Research Progress on Angiogenesis Imbalance and Pathogenesis of Preeclampsia and Predictive Treatment","authors":"Chenyang Dai","doi":"10.31579/2578-8965/124","DOIUrl":"https://doi.org/10.31579/2578-8965/124","url":null,"abstract":"Preeclampsia, one of the unique diseases of pregnancy, is a systemic vascular disease induced by various factors. Its main feature is that new-onset hypertension and proteinuria will appear after 20 weeks of pregnancy. Preeclampsia is the main cause of morbidity and mortality in pregnant women and perinatal babies. Many clinical and experimental studies have shownthat the pathological basis of preeclampsia is maternal endothelial dysfunction caused by placental factors. Moreover, it has been determined that the increase in placental anti-angiogenic factors is the main cause of vascular endothelial dysfunction and systemic vascular dysfunction in pregnant women. This review summarizes the latest advancesin the molecular mechanisms of endothelial dysfunction caused by placental anti-angiogenic factors and new clinical strategies based on these findings.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80825268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Even our early ancestors knew the Sunlight’s importance for life. It gives “life” to life. Most living things have benefitted with it, not only animals, plants, it but even some germs also need it. Both men and women are benefitted with the sunlight, however it is noticed that women is more benefitted by the sunlight than men.
{"title":"Importance of Light in Female’s Life","authors":"PD Gupta","doi":"10.31579/2578-8965/098","DOIUrl":"https://doi.org/10.31579/2578-8965/098","url":null,"abstract":"Even our early ancestors knew the Sunlight’s importance for life. It gives “life” to life. Most living things have benefitted with it, not only animals, plants, it but even some germs also need it. Both men and women are benefitted with the sunlight, however it is noticed that women is more benefitted by the sunlight than men.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88492958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vida Tajiknia, S. Hassani, H. Seifmanesh, A. Afrasiabi, Hamid Hosseinpour
When it comes to gynecologic cancer, ovarian cancer with no doubt is the deadliest and most challenging. The reason often falls into the late presentation, in fact the clinical symptoms are not prominent until the disease is disseminated In patients with advanced ovarian cancer cytoreductive surgery procedure is the key element in treatment plan. One of the best tools to predict successful and complete cytoreductive surgery is using prior imaging. Magnetic resonance imaging is one of the newly described imaging modality for advanced ovarian cancer patients selected for cytoreductive surgery. Here we discussed the application of MRI in advanced ovarian cancer underwent cytoreductive surgery.
{"title":"Role of MRI in Pre-Operative Assessment of Patients with Advanced Ovarian Cancer Candidate for Cytoreductive Surgery, A Brief Review","authors":"Vida Tajiknia, S. Hassani, H. Seifmanesh, A. Afrasiabi, Hamid Hosseinpour","doi":"10.31579/2578-8965/107","DOIUrl":"https://doi.org/10.31579/2578-8965/107","url":null,"abstract":"When it comes to gynecologic cancer, ovarian cancer with no doubt is the deadliest and most challenging. The reason often falls into the late presentation, in fact the clinical symptoms are not prominent until the disease is disseminated In patients with advanced ovarian cancer cytoreductive surgery procedure is the key element in treatment plan. One of the best tools to predict successful and complete cytoreductive surgery is using prior imaging. Magnetic resonance imaging is one of the newly described imaging modality for advanced ovarian cancer patients selected for cytoreductive surgery. Here we discussed the application of MRI in advanced ovarian cancer underwent cytoreductive surgery.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88648656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rechitsky, T. Pakhalchuk, M. Prokhorovich, A. Kuliev
Inherited cancer predisposition is presently one of the major indications for preimplantation genetic testing (PGT), providing an option for couplers at risk to avoid the birth of an offspring with predisposition to cancer. We present here our experience of 35 of 874 PGT cycles for cancer, in which in addition to BRCA1/2 the couples were at risk to another genetic conditions as well, for which PGT was performed together with PGT for breast cancer. This resulted in in birth of 20 mutation free children with not only unaffected for the tested genetic condition, but also without risk of developing cancer. This is a part of our overall PGT series of 6,204 PGT cases for monogenic disorders (PGT-M), with 2,517 resulting births, free of genetic disorder. The accumulated experience, demonstrates considerable progress in using PGT for avoiding the birth of affected children together with avoiding predisposition to cancer.
{"title":"Combined PGT for Breast Cancer and Other Inherited Conditions","authors":"S. Rechitsky, T. Pakhalchuk, M. Prokhorovich, A. Kuliev","doi":"10.31579/2578-8965/112","DOIUrl":"https://doi.org/10.31579/2578-8965/112","url":null,"abstract":"Inherited cancer predisposition is presently one of the major indications for preimplantation genetic testing (PGT), providing an option for couplers at risk to avoid the birth of an offspring with predisposition to cancer. We present here our experience of 35 of 874 PGT cycles for cancer, in which in addition to BRCA1/2 the couples were at risk to another genetic conditions as well, for which PGT was performed together with PGT for breast cancer. This resulted in in birth of 20 mutation free children with not only unaffected for the tested genetic condition, but also without risk of developing cancer. This is a part of our overall PGT series of 6,204 PGT cases for monogenic disorders (PGT-M), with 2,517 resulting births, free of genetic disorder. The accumulated experience, demonstrates considerable progress in using PGT for avoiding the birth of affected children together with avoiding predisposition to cancer.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75842557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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