Flaviu Ionut Faur, A. Clim, Ionel Nati, A. Dobrescu
Introduction: In the literature ovarian tumors are knowed to be one of the most deadliest gynecological malignancies [1-4]. In US this type of malignancy represents 2.3 % of all cancer-related death and about 4 % of all new cancer cases among women. There are several studies that have reported the role of lipid profiles and it’s role in ovarian tumorigenesis. Fatty acids are essential for cancer cells progression[4-8]. In our study we investigated the true differance in circulating lipid profiles (total cholesterol TC, triglyceride TG, high-density lipoprotein cholesterol HDL, low density lipoprotein cholesterol LDL) among patients with and without ovarian tumors (OT) using a meta-analytical approach. Mehods: The meta-analysis was conducted using the MOOSE guidelines. PubMed, EMBASE and Cochrane Library were extensively searched ( with a period of publication restriction between 2007 and 2019) to indetify published studies using the following keywords: “ total cholesterol ”, “high-density lipoprotein”, “ triglycerides ”, “ low-density lipoprotein ”, “ ovarian cancer”, “ ovarian tumor ”, “ lipid profile ”. The search methodology is shown in Fig. 1 and all references of retrieved articles were searched manually. Results: Seven studies, involving 1542 OT cases and 2195 non-cases of OT were included in this meta-analysis and I² statistics ranged between 97 and 99%. Mean circulating TC and HDL were significantly lower among OT cases compared to non-OT cases (P<0.04 and P<0.005). Conclusion: There is a modest significant association between circulating HDL and risk of ovarian tumor but it is crucial to elucidate the implications of HDL in tumor manifestations and growth.
{"title":"Lipid profile an important risk factor in patients with ovarian tumors: a meta-analysis","authors":"Flaviu Ionut Faur, A. Clim, Ionel Nati, A. Dobrescu","doi":"10.31579/2578-8965/108","DOIUrl":"https://doi.org/10.31579/2578-8965/108","url":null,"abstract":"Introduction: In the literature ovarian tumors are knowed to be one of the most deadliest gynecological malignancies [1-4]. In US this type of malignancy represents 2.3 % of all cancer-related death and about 4 % of all new cancer cases among women. There are several studies that have reported the role of lipid profiles and it’s role in ovarian tumorigenesis. Fatty acids are essential for cancer cells progression[4-8]. In our study we investigated the true differance in circulating lipid profiles (total cholesterol TC, triglyceride TG, high-density lipoprotein cholesterol HDL, low density lipoprotein cholesterol LDL) among patients with and without ovarian tumors (OT) using a meta-analytical approach. Mehods: The meta-analysis was conducted using the MOOSE guidelines. PubMed, EMBASE and Cochrane Library were extensively searched ( with a period of publication restriction between 2007 and 2019) to indetify published studies using the following keywords: “ total cholesterol ”, “high-density lipoprotein”, “ triglycerides ”, “ low-density lipoprotein ”, “ ovarian cancer”, “ ovarian tumor ”, “ lipid profile ”. The search methodology is shown in Fig. 1 and all references of retrieved articles were searched manually. Results: Seven studies, involving 1542 OT cases and 2195 non-cases of OT were included in this meta-analysis and I² statistics ranged between 97 and 99%. Mean circulating TC and HDL were significantly lower among OT cases compared to non-OT cases (P<0.04 and P<0.005). Conclusion: There is a modest significant association between circulating HDL and risk of ovarian tumor but it is crucial to elucidate the implications of HDL in tumor manifestations and growth.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84632516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Tanos, Sayed El-Akhras, M. Abo-elenen, Christiana Demetriou, Nafissa El Badawy, Safinez Balami
Study question: What is the correlation of bladder wall endometriosis histological location, to the severity of peritoneal endometriosis in infertility patients? Summary answer: Secondary infertility, back pain, micturition problems, history of ectopic pregnancy and number of abortions can probably be considered as high-risk factors for bladder wall endometriosis for infertility patients. What is known already: Bladder and/or ureter endometriosis occur in 70–85% among patients with deep infiltrating endometriosis. The knowledge regarding the bladder wall involvement with endometriosis in association to peritoneal endometriosis and infertility patients’ clinical characteristics is limited. Study design, size, duration: Retrospective, longitudinal cohort, Sixty-six, primary and secondary infertility patients, collection of surgical and clinical data between 2010 to 2018. Participants/materials, setting, and methods: An experienced histopathologist on endometriosis was asked to review all the patients’ histopathological results. The histopathological reported findings were reviewed prior to the study to reassure the bladder wall depth of endometriosis involvement. The operation and tissue macroscopic description reports before processing were also reviewed. Attention was paid for possible discrepancies or missed important data that could influence the histopathological results. In cases where results were equivocal, the paraffin blocks were available for additional sections for reassuring the diagnosis. An extra effort was made to meticulously observe and identify the involvement of the bladder serosa, muscularis and mucosa with endometriotic cells and glands. Main results and the role of chance: Primary infertility was the indication for the current laparoscopic surgeries in 32 out of 66 (48.5%) patients and secondary infertility for the rest of the group. The highest incidence of bladder endometriosis (BE) was detected on the serosa of 12 patients and in the detrusor muscle (DM) of 11 cases. Bladder serosa endometriosis (BSE) was significantly more prominent among patients with history of ectopic pregnancy (p=0.004) and among patients with secondary infertility (p=0.029). Destrusor muscle endometriosis (DME) was significantly more frequent (p=0.012) in patients with increasing number of abortions. DME highest rates of 37.7% were observed among the severe spread of abdominal endometriosis as compared to 19% of the cases with bladder serosa endometriosis. No statistically significant difference found between serosa and detrusor muscle endometriosis involvement, when compared to severity and spread of endometriosis within the abdominal cavity. Back pain was most prominent with statistical significant difference (p=0.007) in 8 patients with BSE + DME as compared with other groups of patients (4 BSE, 3 DME and 3 BME+DME patients). Among 30 cases with an ovarian endometrioma detected by TVU, DME was diagnosed in 13 patients, in serosa of 10, and in sero
研究问题:不孕患者膀胱壁子宫内膜异位症的组织学位置与腹膜子宫内膜异位症的严重程度有何相关性?总结回答:继发性不孕、背部疼痛、排尿问题、异位妊娠史、流产次数等可能是不孕患者膀胱壁子宫内膜异位症的高危因素。已知情况:70-85%的深浸润性子宫内膜异位症患者发生膀胱和/或输尿管子宫内膜异位症。关于膀胱壁累及子宫内膜异位症与腹膜子宫内膜异位症和不孕症患者临床特征的关系的知识是有限的。研究设计、规模、持续时间:回顾性、纵向队列，66例原发性和继发性不孕症患者，收集2010年至2018年的手术和临床数据。参与者/材料、环境和方法:要求一位经验丰富的子宫内膜异位症组织病理学家审查所有患者的组织病理学结果。在研究之前，我们回顾了组织病理学报告的结果，以确定子宫内膜异位症累及的膀胱壁深度。并对加工前的手术及组织宏观描述报告进行了综述。注意可能的差异或遗漏的重要数据可能影响组织病理学结果。在结果不明确的情况下，石蜡块可用于额外的切片，以确保诊断。我们做了额外的努力，仔细观察和确定膀胱浆膜、肌层和粘膜与子宫内膜异位症细胞和腺体的累及。主要结果及偶然性的作用:66例患者中有32例(48.5%)为原发性不孕，其余患者为继发性不孕。膀胱子宫内膜异位症(BE)发生率最高的部位为浆膜(12例)和逼尿肌(DM)(11例)。膀胱浆膜子宫内膜异位症(BSE)在有异位妊娠史的患者(p=0.004)和继发性不孕患者(p=0.029)中更为突出。逼尿肌子宫内膜异位症(DME)在流产次数增加的患者中更为常见(p=0.012)。重度腹部子宫内膜异位症的DME发生率最高，为37.7%，而膀胱浆膜性子宫内膜异位症的DME发生率为19%。与腹腔内子宫内膜异位症的严重程度和扩散相比，浆膜和逼尿肌子宫内膜异位症的受累没有统计学上的显著差异。8例BSE +DME患者与其他组(4例BSE、3例DME和3例BME+DME)相比，背部疼痛最为突出，差异有统计学意义(p=0.007)。在TVU检测的30例卵巢子宫内膜异位瘤中，13例诊断为DME, 10例诊断为浆膜，6例诊断为浆膜和DM。统计学分析采用Pearson卡方、Fisher精确检验和Kruskal-Wallis检验，采用STATA version 15 SE (StataCorp.)进行。2017)。局限性，谨慎的原因:这是一项队列回顾性研究。除了诊断和治疗过的子宫内膜异位症外，其他子宫内膜异位症也可能与BW有关。原发性和继发性不孕症患者的混合也可能影响结果，尽管统计分析未显示BWE、临床症状和手术结果有任何意义。BE很少是一种孤立的情况，其他形式的子宫内膜异位症经常伴随着更广泛的研究结果:在所有膀胱子宫内膜异位症和不孕症的病例中，逼尿肌和膀胱浆膜的累及率分别为68%和32%。腹膜子宫内膜异位症的严重程度可能指导术中对膀胱子宫内膜异位症进行细致的检查。
{"title":"Correlation of Bladder Wall Endometriosis Histological Location, To Infertility Patients’ Clinical Characteristics and Severity of Peritoneal Endometriosis","authors":"V. Tanos, Sayed El-Akhras, M. Abo-elenen, Christiana Demetriou, Nafissa El Badawy, Safinez Balami","doi":"10.31579/2578-8965/102","DOIUrl":"https://doi.org/10.31579/2578-8965/102","url":null,"abstract":"Study question: What is the correlation of bladder wall endometriosis histological location, to the severity of peritoneal endometriosis in infertility patients? Summary answer: Secondary infertility, back pain, micturition problems, history of ectopic pregnancy and number of abortions can probably be considered as high-risk factors for bladder wall endometriosis for infertility patients. What is known already: Bladder and/or ureter endometriosis occur in 70–85% among patients with deep infiltrating endometriosis. The knowledge regarding the bladder wall involvement with endometriosis in association to peritoneal endometriosis and infertility patients’ clinical characteristics is limited. Study design, size, duration: Retrospective, longitudinal cohort, Sixty-six, primary and secondary infertility patients, collection of surgical and clinical data between 2010 to 2018. Participants/materials, setting, and methods: An experienced histopathologist on endometriosis was asked to review all the patients’ histopathological results. The histopathological reported findings were reviewed prior to the study to reassure the bladder wall depth of endometriosis involvement. The operation and tissue macroscopic description reports before processing were also reviewed. Attention was paid for possible discrepancies or missed important data that could influence the histopathological results. In cases where results were equivocal, the paraffin blocks were available for additional sections for reassuring the diagnosis. An extra effort was made to meticulously observe and identify the involvement of the bladder serosa, muscularis and mucosa with endometriotic cells and glands. Main results and the role of chance: Primary infertility was the indication for the current laparoscopic surgeries in 32 out of 66 (48.5%) patients and secondary infertility for the rest of the group. The highest incidence of bladder endometriosis (BE) was detected on the serosa of 12 patients and in the detrusor muscle (DM) of 11 cases. Bladder serosa endometriosis (BSE) was significantly more prominent among patients with history of ectopic pregnancy (p=0.004) and among patients with secondary infertility (p=0.029). Destrusor muscle endometriosis (DME) was significantly more frequent (p=0.012) in patients with increasing number of abortions. DME highest rates of 37.7% were observed among the severe spread of abdominal endometriosis as compared to 19% of the cases with bladder serosa endometriosis. No statistically significant difference found between serosa and detrusor muscle endometriosis involvement, when compared to severity and spread of endometriosis within the abdominal cavity. Back pain was most prominent with statistical significant difference (p=0.007) in 8 patients with BSE + DME as compared with other groups of patients (4 BSE, 3 DME and 3 BME+DME patients). Among 30 cases with an ovarian endometrioma detected by TVU, DME was diagnosed in 13 patients, in serosa of 10, and in sero","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89745724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Many studies determined effect of plant extract on plant pathogens and human pathogens. Alhagi maurorum is considered as one of the important medicinal plants in Iraq. It is used for urinary tract infection, rheumatic pains and liver disorders. Study the Inhibition Effect of Alhagi extract on oral microorganisms as Streptococci, Actinobacillus and Staphylococci, with (0, 10, 50 and 100 percentages). The concentrations of 0% has not any inhibition effect, 10%, has a slight inhibition effect against oral Streptococci and Actinobacillus, but has not effect on Staphylococci. 50%, has an inhibition effect against oral Streptococci more than E-coli, but has not effect on Staphylococci, but 100%, has a wide inhibition effect a against oral Streptococci more than Actinobacillus except Staphylococci has not effect. The lack of inhibition effect at the concentration of 0% and 10% of Alhagi maurorum aqueous extract may be returned to the limits or decline of active components in these low concentrations of aqueous extract. In addition, studies indicate that there are many factors have an effect in the minimizing the impact of plant extracts.
{"title":"Study Inhibitory Effect of Alhagi Extract on Oral Microorganisms","authors":"Wasan Mohammed Alsewidi","doi":"10.31579/2578-8965/106","DOIUrl":"https://doi.org/10.31579/2578-8965/106","url":null,"abstract":"Many studies determined effect of plant extract on plant pathogens and human pathogens. Alhagi maurorum is considered as one of the important medicinal plants in Iraq. It is used for urinary tract infection, rheumatic pains and liver disorders. Study the Inhibition Effect of Alhagi extract on oral microorganisms as Streptococci, Actinobacillus and Staphylococci, with (0, 10, 50 and 100 percentages). The concentrations of 0% has not any inhibition effect, 10%, has a slight inhibition effect against oral Streptococci and Actinobacillus, but has not effect on Staphylococci. 50%, has an inhibition effect against oral Streptococci more than E-coli, but has not effect on Staphylococci, but 100%, has a wide inhibition effect a against oral Streptococci more than Actinobacillus except Staphylococci has not effect. The lack of inhibition effect at the concentration of 0% and 10% of Alhagi maurorum aqueous extract may be returned to the limits or decline of active components in these low concentrations of aqueous extract. In addition, studies indicate that there are many factors have an effect in the minimizing the impact of plant extracts.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82242466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Although many interventions to address vaccine hesitancy until now have operated on the presumption that misperceptions are due to a lack of knowledge about HPV and the vaccine, this may not always be the reason behind vaccine hesitancy. Nyhan et. al found [1] that correcting myths about vaccines- such as autism links or vaccine side effects- do not increase vaccine rates among adolescents. Medical providers play a crucial role on influencing parents’ decision to vaccinate. In a study exploring how vaccination coverage among children 19-35 months old is associated with health care providers' influence on the parents' decision to vaccinate, parents who report their providers as being influential in the study are twice as likely to respond that vaccines are safe for children [2]. In the 2016 Clinical Report on Countering Vaccine Hesitancy by the American Academy of Pediatrics, motivational interviewing is listed as a potential communication technique that may be useful as pediatricians discuss vaccines with vaccine-hesitant parents. Research Question: The research attempting to find the best approaches to reverse the increasing rates of unvaccinated minors is limited and inconclusive. This project addressed the impact of medical providers’ attitudes of HPV vaccination on their early adolescent patient populations. Methods: Our cohort prospective study first examined medical providers’ baseline attitudes and approaches of HPV vaccination in privately insured clinics in rural areas of Nebraska. A survey was sent to eleven Phase III patient centered medical home (PCMH) NE clinics. The survey assessed medical staffs’ attitudes and approaches to HPV vaccination, particularly among specific patient age groups. In addition to each clinic’s collective survey responses, baseline HPV vaccination data was collected at eleven Phase 3 PCMH rural clinics in Nebraska for pediatric patients 11-15-years-old. The follow-up intervention implemented educational interventions in the clinics to increase HPV vaccination rates for pediatric patients 9-15-years-old. Our educational outreach program at the selected 10-13 clinics will serve as these rural clinics’ first efforts to selectively work toward improving HPV vaccination rates. Results: America’s Health Rankings (2017) found 42.4% of adolescents living in rural areas compared to 52.4% in urban areas are up-to-date on their HPV immunizations. The eleven rural clinics selected for the study show only a 0.9% completion of the vaccine series for 9-11-year-old patients (n=855), and 25.0% completion of the series for 12-15-year-old patients (n=1268) as of 2019. This implies a pressing health disparity that needs addressing in rural Nebraskan communities. 92.6% of all respondents chose the 12-15 age range as the patient population the clinics would typically ask about the vaccine versus 59.6% who chose the 9-11 age range. The most chosen reason for not mentioning the HPV vaccine is “parents previously voiced va
背景:尽管到目前为止，许多解决疫苗犹豫的干预措施都是基于这样的假设，即误解是由于缺乏对HPV和疫苗的了解，但这可能并不总是疫苗犹豫背后的原因。Nyhan等人发现[1]纠正关于疫苗的误解——比如与自闭症的联系或疫苗的副作用——并不能提高青少年的疫苗接种率。医疗服务提供者在影响父母接种疫苗的决定方面发挥着至关重要的作用。在一项探索19-35个月大儿童的疫苗接种覆盖率如何与卫生保健提供者对父母接种疫苗决定的影响相关的研究中，报告其提供者在研究中有影响力的父母有两倍的可能性回应疫苗对儿童是安全的[2]。在美国儿科学会(American Academy of Pediatrics)发布的《2016年应对疫苗犹豫临床报告》(2016 Clinical Report on Countering Vaccine犹豫不决)中，动机性访谈被列为一种潜在的沟通技巧，在儿科医生与对疫苗犹豫不决的父母讨论疫苗时可能有用。研究问题:试图找到最佳方法来扭转未接种疫苗的未成年人比例上升的研究是有限的和不确定的。该项目解决了医疗服务提供者对HPV疫苗接种的态度对其早期青少年患者群体的影响。方法:我们的队列前瞻性研究首先检查了内布拉斯加州农村地区私人保险诊所的医疗提供者对HPV疫苗接种的基线态度和方法。一份调查被发送到11个III期以病人为中心的医疗之家(PCMH) NE诊所。该调查评估了医务人员对HPV疫苗接种的态度和方法，特别是在特定的患者年龄组中。除了每家诊所的集体调查反应外，还收集了内布拉斯加州11个3期PCMH农村诊所11-15岁儿科患者的基线HPV疫苗接种数据。随访干预在诊所实施教育干预，以提高9-15岁儿童的HPV疫苗接种率。我们在选定的10-13个诊所开展的教育外展计划将作为这些农村诊所有选择地提高HPV疫苗接种率的第一次努力。结果:美国健康排名(2017年)发现，生活在农村地区的青少年中，有42.4%的人接种了最新的HPV疫苗，而城市地区的这一比例为52.4%。为该研究选择的11个农村诊所显示，截至2019年，9-11岁患者(n=855)的疫苗系列覆盖率仅为0.9%，12-15岁患者(n=1268)的疫苗系列覆盖率仅为25.0%。这意味着迫切需要解决内布拉斯加州农村社区的健康差距问题。92.6%的受访者选择了12-15岁年龄段作为诊所通常询问疫苗的患者群体，而59.6%的受访者选择了9-11岁年龄段。选择不接种HPV疫苗的原因最多的是“父母之前表示对疫苗犹豫”(33.3%)，其次是“没有足够的门诊时间”(22.2%)。导致父母犹豫不决的最常见原因是“他们担心疫苗对孩子不安全”(70.4%)。HPV疫苗最大的好处是“预防多种癌症”(33.3%)，最大的缺点是“多剂量系列完成”(40.7%)和“难以说服父母为未成年人接种”(40.7%)。9-11岁是最难接种疫苗的年龄组(33.3%)。在解决HPV疫苗接种问题时，最困难的情况是“缺乏疫苗教育”(55.6%)，“反对疫苗的宗教原因”(44.4%)和“语言/文化障碍”(37%)。定性结果也分别进行了分析，并侧重于每个诊所在鼓励接种疫苗方面的优势和劣势。讨论:基线患者数据显示，为研究选择的诊所在脆弱年龄组中显示出HPV疫苗接种率的巨大差异。调查结果显示，临床观察显示，父母对HPV疫苗的教育水平较低，以及在患者和医护人员之间进行公开对话时缺乏舒适感。仅关注这两个变量就可以帮助显著提高疫苗接种率。调查结果最终表明，迫切需要有经验支持的教育资源，以加强各个诊所内工作人员之间以及医务人员与患者家属之间的沟通，以持续提高农村诊所的HPV疫苗接种率。
{"title":"Identifying the Roles of Medical Providers when Addressing Barriers to HPV Vaccination Rates in Rural NE Clinics","authors":"Abby Laudi","doi":"10.31579/2578-8965/093","DOIUrl":"https://doi.org/10.31579/2578-8965/093","url":null,"abstract":"Background: Although many interventions to address vaccine hesitancy until now have operated on the presumption that misperceptions are due to a lack of knowledge about HPV and the vaccine, this may not always be the reason behind vaccine hesitancy. Nyhan et. al found [1] that correcting myths about vaccines- such as autism links or vaccine side effects- do not increase vaccine rates among adolescents. Medical providers play a crucial role on influencing parents’ decision to vaccinate. In a study exploring how vaccination coverage among children 19-35 months old is associated with health care providers' influence on the parents' decision to vaccinate, parents who report their providers as being influential in the study are twice as likely to respond that vaccines are safe for children [2]. In the 2016 Clinical Report on Countering Vaccine Hesitancy by the American Academy of Pediatrics, motivational interviewing is listed as a potential communication technique that may be useful as pediatricians discuss vaccines with vaccine-hesitant parents. Research Question: The research attempting to find the best approaches to reverse the increasing rates of unvaccinated minors is limited and inconclusive. This project addressed the impact of medical providers’ attitudes of HPV vaccination on their early adolescent patient populations. Methods: Our cohort prospective study first examined medical providers’ baseline attitudes and approaches of HPV vaccination in privately insured clinics in rural areas of Nebraska. A survey was sent to eleven Phase III patient centered medical home (PCMH) NE clinics. The survey assessed medical staffs’ attitudes and approaches to HPV vaccination, particularly among specific patient age groups. In addition to each clinic’s collective survey responses, baseline HPV vaccination data was collected at eleven Phase 3 PCMH rural clinics in Nebraska for pediatric patients 11-15-years-old. The follow-up intervention implemented educational interventions in the clinics to increase HPV vaccination rates for pediatric patients 9-15-years-old. Our educational outreach program at the selected 10-13 clinics will serve as these rural clinics’ first efforts to selectively work toward improving HPV vaccination rates. Results: America’s Health Rankings (2017) found 42.4% of adolescents living in rural areas compared to 52.4% in urban areas are up-to-date on their HPV immunizations. The eleven rural clinics selected for the study show only a 0.9% completion of the vaccine series for 9-11-year-old patients (n=855), and 25.0% completion of the series for 12-15-year-old patients (n=1268) as of 2019. This implies a pressing health disparity that needs addressing in rural Nebraskan communities. 92.6% of all respondents chose the 12-15 age range as the patient population the clinics would typically ask about the vaccine versus 59.6% who chose the 9-11 age range. The most chosen reason for not mentioning the HPV vaccine is “parents previously voiced va","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87298471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Estrogens are the group of hormones which makes a woman a woman. Girls at menarche start making it and under normal conditions sufficient levels are maintained in the women's body until menopause. During perimenopause, menopause and postmenopause the hormone levels start fluctuating and if maintained low for a longer period, it starts giving various problems. Fluctuating levels of estrogen causes, hot flashes, night sweats, vaginal dryness, depression, and mood swings. Sleep disturbances brain fog and may be heart disease, osteoporosis, obesity and the appearance of unwanted facial hair. These problems can be overcome by supplementing with phytoestrogens or hormone replacement therapy.
{"title":"Effects of Low Estrogens: Vaginal Atrophy","authors":"PD Gupta","doi":"10.31579/2578-8965/096","DOIUrl":"https://doi.org/10.31579/2578-8965/096","url":null,"abstract":"Estrogens are the group of hormones which makes a woman a woman. Girls at menarche start making it and under normal conditions sufficient levels are maintained in the women's body until menopause. During perimenopause, menopause and postmenopause the hormone levels start fluctuating and if maintained low for a longer period, it starts giving various problems. Fluctuating levels of estrogen causes, hot flashes, night sweats, vaginal dryness, depression, and mood swings. Sleep disturbances brain fog and may be heart disease, osteoporosis, obesity and the appearance of unwanted facial hair. These problems can be overcome by supplementing with phytoestrogens or hormone replacement therapy.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84472080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The spread of COVID-19 and the resulted lockdown imposed across the globe has negatively affected the contraceptive drugs market. Many women across the world found it hard to purchase the pills as contraceptive drug manufacturers were facing challenges due to inconsistent supply chains and the workforce.
{"title":"Women Health Awareness, Acquisitions, and Partnerships to Bring New Era for Contraceptive Drugs.","authors":"Ashish M. Gujrathi","doi":"10.31579/2578-8965/099","DOIUrl":"https://doi.org/10.31579/2578-8965/099","url":null,"abstract":"The spread of COVID-19 and the resulted lockdown imposed across the globe has negatively affected the contraceptive drugs market. Many women across the world found it hard to purchase the pills as contraceptive drug manufacturers were facing challenges due to inconsistent supply chains and the workforce.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88794394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is a physiological balance between our systems in our body. When this physiological balance is disturbed, diseases ocur. Infertility; It is defined as not having a pregnancy despite the couples having regular sexual intercourse. Homeopathy, a natural remedy that has been used widely all over the world for 200 years system. It has been recognized by the World Health Organization (WHO) as the second largest treatment method used worldwide. Although it is the most popular form of treatment in India and South America, it is also used by over 30 million people in Europe and millions of other people around the world. A female patient 33 years old who applied to Getat Polk for infertility had also divorsed from her first marriage for 8 years due to infertility. She continued her infertility treatment during her marriage. Tsh 1.93Uıu/ml, t3 3,05 pg/ml,t4 0.76ng/dl. Glukose 82mg/ml, d vitamine 8ng/ml, b12 270pg/ml, total cholesterol 176mg/ml, creatinine 0.63mg/dl tg 77 mg/dl fe 38ug/dl AST 19 U/L E stradiole 46ug/l LH 12,42IU/L Ferritine 8.51 ug/l hemoglobine 11.8g/dl .After a detailed anamnesis, the patient was started on Hyos c30 2*1, Ignatia c30 2*1, and folliculunum c200 2*1 (1st and 14th days of menstruation) in December 2020. The patient was 7 weeks pregnant in september 2021.β-Hcg 15000Mıu/ml Fe 171 ug/dl. Hormonal balance in women is very sensitive and easily effected, either by endogen or exogen disturbances. Pressure and suppression induced by dominant forces on an individual such as dominant parents, husband, harassment at work or religions dominance can be a cause to create a so called Folliculinum state, as well as results from immune system suffering after long lasting and profound infection, which is suppressed by medication.
我们身体各系统之间有一种生理平衡。当这种生理平衡被破坏时，疾病就会发生。不孕症;它被定义为尽管夫妻有规律的性行为，但没有怀孕。顺势疗法是一种在世界各地广泛使用了200年的自然疗法。它已被世界卫生组织(WHO)认定为全球第二大治疗方法。虽然它是印度和南美最流行的治疗形式，但在欧洲也有超过3000万人使用它，世界各地还有数百万人使用它。一名33岁的女性患者因不孕症向Getat Polk申请，她也因不孕症与第一次婚姻离婚8年。她在结婚期间继续接受不孕治疗。Tsh 1.93Uıu/ml, t3 3,05 pg/ml,t4 0.76ng/dl。葡萄糖82mg/ml, d维生素8ng/ml, b12 270pg/ml，总胆固醇176mg/ml，肌酐0.63mg/dl tg 77 mg/dl fe 38ug/dl AST 19 U/L E stradiole 46ug/ L LH 12 42IU/L铁氨酸8.51 ug/ L血红蛋白11.8g/dl。详细分析后，患者于2020年12月(月经第1、14天)开始服用Hyos c30 2*1、Ignatia c30 2*1、卵泡c200 2*1。该患者于2021年9月怀孕7周。β-Hcg 15000Mıu/ml Fe 171 ug/dl。女性的荷尔蒙平衡非常敏感，容易受到内因或外因干扰而受到影响。来自强势的父母、丈夫、工作中的骚扰或宗教主导等主导力量对个体造成的压力和抑制可能是造成所谓卵泡状态的原因，也可能是免疫系统在长期持续和深刻感染后受到影响的结果，这种影响被药物抑制。
{"title":"A Homeopathic Treatment İn a Female Patient with İnfertility","authors":"H. Alp","doi":"10.31579/2578-8965/101","DOIUrl":"https://doi.org/10.31579/2578-8965/101","url":null,"abstract":"There is a physiological balance between our systems in our body. When this physiological balance is disturbed, diseases ocur. Infertility; It is defined as not having a pregnancy despite the couples having regular sexual intercourse. Homeopathy, a natural remedy that has been used widely all over the world for 200 years system. It has been recognized by the World Health Organization (WHO) as the second largest treatment method used worldwide. Although it is the most popular form of treatment in India and South America, it is also used by over 30 million people in Europe and millions of other people around the world. A female patient 33 years old who applied to Getat Polk for infertility had also divorsed from her first marriage for 8 years due to infertility. She continued her infertility treatment during her marriage. Tsh 1.93Uıu/ml, t3 3,05 pg/ml,t4 0.76ng/dl. Glukose 82mg/ml, d vitamine 8ng/ml, b12 270pg/ml, total cholesterol 176mg/ml, creatinine 0.63mg/dl tg 77 mg/dl fe 38ug/dl AST 19 U/L E stradiole 46ug/l LH 12,42IU/L Ferritine 8.51 ug/l hemoglobine 11.8g/dl .After a detailed anamnesis, the patient was started on Hyos c30 2*1, Ignatia c30 2*1, and folliculunum c200 2*1 (1st and 14th days of menstruation) in December 2020. The patient was 7 weeks pregnant in september 2021.β-Hcg 15000Mıu/ml Fe 171 ug/dl. Hormonal balance in women is very sensitive and easily effected, either by endogen or exogen disturbances. Pressure and suppression induced by dominant forces on an individual such as dominant parents, husband, harassment at work or religions dominance can be a cause to create a so called Folliculinum state, as well as results from immune system suffering after long lasting and profound infection, which is suppressed by medication.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85153240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Eskandar, W. Alasmari, Fawaz Idris, Huda Nadwi, E. Radwan, Tahir Mubarak, Rayan Eskandar
Objective: The aim of this study was to determine the effect of different altitudes in the Southwestern region of Saudi Arabia on ICSI outcomes, fertilization rate, embryo quality, pregnancy rate, and miscarriage rates for infertile couples. Materials and Methods: This is a retrospective study on 551 infertile couples carried out in the Assisted Reproductive Technology unit at the Maternity and Childern Hospital in Abha, Saudi Arabia between 2018 and 2019 to compare ICSI outcomes in different altitudes. Low altitude (205 patients), mild altitude (86 patients) and high altitude (260 patients). Main result measurements: fertilization rates, embryo quality, clinical pregnancy and miscarriage rates at different altitudes. Results: The data showed that there were no significant differences (P>0.67) in fertilization rates and the number of good-quality embryos between different altitudes. Importantly, clinical pregnancy rates were similar between groups and there was no significant difference in the miscarriage rates between high, mild and low altitudes. Conclusions: This study demonstrates that there is now increased risk of miscarriage or low pregnancy rates with different altitudes in Southwestern region of Saudi Arabia. This suggests that altitude changes has no obvious risk on pregnancy rate and pregnancy outcome.
{"title":"Impact of Living in Different Altitudes on Intracytoplasmic Sperm Injection (ICSI) Outcomes for Infertile Couples in Southwestern Region of Saudi Arabia, a Retrospective Study","authors":"M. Eskandar, W. Alasmari, Fawaz Idris, Huda Nadwi, E. Radwan, Tahir Mubarak, Rayan Eskandar","doi":"10.31579/2578-8965/104","DOIUrl":"https://doi.org/10.31579/2578-8965/104","url":null,"abstract":"Objective: The aim of this study was to determine the effect of different altitudes in the Southwestern region of Saudi Arabia on ICSI outcomes, fertilization rate, embryo quality, pregnancy rate, and miscarriage rates for infertile couples. Materials and Methods: This is a retrospective study on 551 infertile couples carried out in the Assisted Reproductive Technology unit at the Maternity and Childern Hospital in Abha, Saudi Arabia between 2018 and 2019 to compare ICSI outcomes in different altitudes. Low altitude (205 patients), mild altitude (86 patients) and high altitude (260 patients). Main result measurements: fertilization rates, embryo quality, clinical pregnancy and miscarriage rates at different altitudes. Results: The data showed that there were no significant differences (P>0.67) in fertilization rates and the number of good-quality embryos between different altitudes. Importantly, clinical pregnancy rates were similar between groups and there was no significant difference in the miscarriage rates between high, mild and low altitudes. Conclusions: This study demonstrates that there is now increased risk of miscarriage or low pregnancy rates with different altitudes in Southwestern region of Saudi Arabia. This suggests that altitude changes has no obvious risk on pregnancy rate and pregnancy outcome.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86873652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Pérez Febles, Victoria Pascual Escudero, S. De Miguel Manso, M. Lopez pais, D. Viruega Cuaresma, P. Suárez Mansilla
Background: Vulvovaginal atrophy affects approximately 45% of middle-aged women, as a result of decreased estrogen circulating levels and is often associated with vulvovaginal discomfort in menopausal patients. The spectrum of adverse consequences makes long-term treatment essential, not only for symptom relief, but also to avoid further complications. These symptoms can even be worsened if other vulvar conditions coexist, such as inflammatory dermatoses. Clinical presentation: We present two cases of patients with severe vulvar atrophy and craurosis, who required vulvo-vaginal opening associated with medical treatment. In both patients, we diagnosed severe genitourinary syndrome of menopause (GSM) complicated by vulvar lichen sclerosus, a very rare clinical situation. In case 1, the symptoms had progressed despite local estrogen treatment for vulvovaginal atrophy, and lichen wasn’t considered in previous check-ups. In contrast, patient nº 2 presented in the ER with impossibility to urinate and was then diagnosed and treated for underlying causes. Conclusions: GSM treatment should be a priority. The absence of improvement or progression of genital atrophy should alert the specialist to the coexistence of other vulvar pathologies.
{"title":"Vulvar Craurosis due to Severe Genitourinary Syndrome of Menopause Complicated by Lichen Sclerosus: Two Case Reports and Literature Review","authors":"M. Pérez Febles, Victoria Pascual Escudero, S. De Miguel Manso, M. Lopez pais, D. Viruega Cuaresma, P. Suárez Mansilla","doi":"10.31579/2578-8965/100","DOIUrl":"https://doi.org/10.31579/2578-8965/100","url":null,"abstract":"Background: Vulvovaginal atrophy affects approximately 45% of middle-aged women, as a result of decreased estrogen circulating levels and is often associated with vulvovaginal discomfort in menopausal patients. The spectrum of adverse consequences makes long-term treatment essential, not only for symptom relief, but also to avoid further complications. These symptoms can even be worsened if other vulvar conditions coexist, such as inflammatory dermatoses. Clinical presentation: We present two cases of patients with severe vulvar atrophy and craurosis, who required vulvo-vaginal opening associated with medical treatment. In both patients, we diagnosed severe genitourinary syndrome of menopause (GSM) complicated by vulvar lichen sclerosus, a very rare clinical situation. In case 1, the symptoms had progressed despite local estrogen treatment for vulvovaginal atrophy, and lichen wasn’t considered in previous check-ups. In contrast, patient nº 2 presented in the ER with impossibility to urinate and was then diagnosed and treated for underlying causes. Conclusions: GSM treatment should be a priority. The absence of improvement or progression of genital atrophy should alert the specialist to the coexistence of other vulvar pathologies.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82435434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of the study is to compare the pipelle method and hysteroscopy with D&C in postmenopausal patients Methods: In this prospective study, only those postmenopausal patients with postmenopausal bleeding and/or with a sonographically highly developed endometrium who were referred for hysteroscopy with D&C were included. A total of 92 patients were included in this study. Before each procedure, patients were explicitly informed about the study and gave consent. On the condition of anonymity of personal data (surname and first name, date of birth) and after signing a special informed consent form, the patients were allowed to be included in the study. The study was performed as a double-blind study. The obtained histologies (from pipelle and D&C) were sent separately to the same pathologist. Results: The group with malignant and premalignant findings has a central role in our study. After evaluation of the histologically malignant findings from the pipelle and the D&C, the sensitivity of the pipelle in our study was 82%. Conclusion: Endometrial biopsy is an important step to exclude endometrial carcinoma in postmenopausal bleeding. The aim is to minimize the burden and invasiveness of the procedure while maintaining a high degree of diagnostic certainty to avoid unnecessary invasive surgery. The pipelle sampling can be used as an outpatient method without anaesthesia during routine examination. Our study shows that this method of sampling is a safe, accurate and cost-effective outpatient procedure with high sensitivity for the detection of endometrial carcinoma.
{"title":"Comparison of Pipelle and Hysteroscopy with D&C in Postmenopausal Patients","authors":"E. Piriyev, S. Schiermeier, T. Römer","doi":"10.31579/2578-8965/105","DOIUrl":"https://doi.org/10.31579/2578-8965/105","url":null,"abstract":"Objective: The aim of the study is to compare the pipelle method and hysteroscopy with D&C in postmenopausal patients Methods: In this prospective study, only those postmenopausal patients with postmenopausal bleeding and/or with a sonographically highly developed endometrium who were referred for hysteroscopy with D&C were included. A total of 92 patients were included in this study. Before each procedure, patients were explicitly informed about the study and gave consent. On the condition of anonymity of personal data (surname and first name, date of birth) and after signing a special informed consent form, the patients were allowed to be included in the study. The study was performed as a double-blind study. The obtained histologies (from pipelle and D&C) were sent separately to the same pathologist. Results: The group with malignant and premalignant findings has a central role in our study. After evaluation of the histologically malignant findings from the pipelle and the D&C, the sensitivity of the pipelle in our study was 82%. Conclusion: Endometrial biopsy is an important step to exclude endometrial carcinoma in postmenopausal bleeding. The aim is to minimize the burden and invasiveness of the procedure while maintaining a high degree of diagnostic certainty to avoid unnecessary invasive surgery. The pipelle sampling can be used as an outpatient method without anaesthesia during routine examination. Our study shows that this method of sampling is a safe, accurate and cost-effective outpatient procedure with high sensitivity for the detection of endometrial carcinoma.","PeriodicalId":19413,"journal":{"name":"Obstetrics Gynecology and Reproductive Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84473135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：