Biraj Shrestha, I. Vlachos, J. Adkinson, L. Iasemidis
Motor imagery and motor movement are two distinct tasks with underlying similar neurological mechanisms. We sought to identify the electroencephalographic (EEG) differences between real and imaginary hand movements. Phase Locking Value (PLV) was employed to estimate brain's connectivity and create a network that was then studied on the basis of brain region centrality. We observed that the frontal/prefrontal cortex exhibits higher centrality in the θ band during motor movement than motor imagery tasks. Additionally, difference between left and right hand tasks was observed in the μ band at the somatosensory association cortex post-tasks' completion. These preliminary results indicate that, by proper EEG analysis, it may be possible to distinguish between motor imagery and motor movement.
{"title":"Distinguishing Motor Imagery from Motor Movement Using Phase Locking Value and Eigenvector Centrality","authors":"Biraj Shrestha, I. Vlachos, J. Adkinson, L. Iasemidis","doi":"10.1109/SBEC.2016.46","DOIUrl":"https://doi.org/10.1109/SBEC.2016.46","url":null,"abstract":"Motor imagery and motor movement are two distinct tasks with underlying similar neurological mechanisms. We sought to identify the electroencephalographic (EEG) differences between real and imaginary hand movements. Phase Locking Value (PLV) was employed to estimate brain's connectivity and create a network that was then studied on the basis of brain region centrality. We observed that the frontal/prefrontal cortex exhibits higher centrality in the θ band during motor movement than motor imagery tasks. Additionally, difference between left and right hand tasks was observed in the μ band at the somatosensory association cortex post-tasks' completion. These preliminary results indicate that, by proper EEG analysis, it may be possible to distinguish between motor imagery and motor movement.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"237 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114605916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yazan S. Batarseh, Hisham Qosa, Khalid Elsayed, J. Keller, A. Kaddoumi
Summary form only given. Mediterranean diet (MD) is considered one of the most health promoting diets adopted initially by the Mediterranean population. Recent studies showed a link between MD and lowering the incidence of mild cognitive impairment and Alzheimer's disease (AD). Clinical and preclinical studies have suggested several health promoting effects for the dietary consumption of extra-virgin olive oil (EVOO), a major component of MD, that could protect and decrease the risk of developing AD. Moreover, recent studies have linked this protective effect to oleocanthal, a phenolic secoiridoid component of EVOO. Here we provide evidence to support the role of EVOO and oleocanthal in enhancing the clearance of amyloid-beta (Aβ), a major pathological hallmark in AD, and reducing the overall inflammatory burden on the brain. In our study, both EVOO and oleocanthal treatment significantly decreased Aβ load in the hippocampal parenchyma and microvessels. Furthermore, our mechanistic studies demonstrated an effect on increasing the expression of important amyloid clearance proteins at the blood-brain barrier (BBB) including P-glycoprotein (P-gp) and low density lipoprotein receptor-related protein 1 (LRP1), and to activate the ApoE-dependent amyloid clearance pathway in the mice brains. Additionally, oleocanthal was able to reduce astrocytes activation and IL-1β levels. The reduction in Aβ levels and microvessels deposition could be explained, at least in part, to the enhanced Aβ clearance across the BBB and by ApoE-dependent pathway. In addition, oleocanthal demonstrated an anti-inflammatory effect by reducing astrocytes activation and IL-1β brain levels, which emphasize the importance of considering EVOO and oleocanthal as a potential therapeutic interventions in AD.
{"title":"Extra-Virgin Olive Oil and Oleocanthal Reduce Amyloid ß Load in Alzheimer's Disease Mouse Model","authors":"Yazan S. Batarseh, Hisham Qosa, Khalid Elsayed, J. Keller, A. Kaddoumi","doi":"10.1109/SBEC.2016.42","DOIUrl":"https://doi.org/10.1109/SBEC.2016.42","url":null,"abstract":"Summary form only given. Mediterranean diet (MD) is considered one of the most health promoting diets adopted initially by the Mediterranean population. Recent studies showed a link between MD and lowering the incidence of mild cognitive impairment and Alzheimer's disease (AD). Clinical and preclinical studies have suggested several health promoting effects for the dietary consumption of extra-virgin olive oil (EVOO), a major component of MD, that could protect and decrease the risk of developing AD. Moreover, recent studies have linked this protective effect to oleocanthal, a phenolic secoiridoid component of EVOO. Here we provide evidence to support the role of EVOO and oleocanthal in enhancing the clearance of amyloid-beta (Aβ), a major pathological hallmark in AD, and reducing the overall inflammatory burden on the brain. In our study, both EVOO and oleocanthal treatment significantly decreased Aβ load in the hippocampal parenchyma and microvessels. Furthermore, our mechanistic studies demonstrated an effect on increasing the expression of important amyloid clearance proteins at the blood-brain barrier (BBB) including P-glycoprotein (P-gp) and low density lipoprotein receptor-related protein 1 (LRP1), and to activate the ApoE-dependent amyloid clearance pathway in the mice brains. Additionally, oleocanthal was able to reduce astrocytes activation and IL-1β levels. The reduction in Aβ levels and microvessels deposition could be explained, at least in part, to the enhanced Aβ clearance across the BBB and by ApoE-dependent pathway. In addition, oleocanthal demonstrated an anti-inflammatory effect by reducing astrocytes activation and IL-1β brain levels, which emphasize the importance of considering EVOO and oleocanthal as a potential therapeutic interventions in AD.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115811370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren R. Molaison, Oluwakemi A. Ojala, S. J. Warren, Carl Mcintyre, Charles E. Taylor
Mammalian blood is a non-Newtonian fluid that decreases in viscosity as the shear rate increases. This complex behavior of the fluid contributes heavily to the complex flow patterns that affect circulatory assist devices. In order to adequately verify these devices in an in vitro setting, a substitute fluid must be used that delivers a level of fidelity that makes the experimental results relevant. Traditional formulations have been based on natural products (e.g. Xanthan Gum) and have required large dilutions (e.g. PMMA). Both of these factors have made the use of these analogs unreliable and difficult to accurately construct, respectively. A new formulation is proposed that addresses the issues of solution reliability and robustness in construction. The formulation is comprised of silicon dioxide and polyalphaolefin. The former is a powder mix and the latter is a solution. The mixing quantities do not require analytical grade equipment to formulate the proper solution within an industry accepted range of error. The liquid system also exhibits a high level of clarity, which makes it compatible with imaging methods used to visualize the flow patterns of the fluid using particle image velocimetry (PIV). Presentation of the liquid system and rheological data will be delivered to support this study's conclusion that this solution is a more adequately suited blood analog for in vitro flow studies of the cardiovascular system.
{"title":"Characterization of a Shear Thinning Fluid System for Cardiovascular Medical Device Assessment","authors":"Lauren R. Molaison, Oluwakemi A. Ojala, S. J. Warren, Carl Mcintyre, Charles E. Taylor","doi":"10.1109/SBEC.2016.89","DOIUrl":"https://doi.org/10.1109/SBEC.2016.89","url":null,"abstract":"Mammalian blood is a non-Newtonian fluid that decreases in viscosity as the shear rate increases. This complex behavior of the fluid contributes heavily to the complex flow patterns that affect circulatory assist devices. In order to adequately verify these devices in an in vitro setting, a substitute fluid must be used that delivers a level of fidelity that makes the experimental results relevant. Traditional formulations have been based on natural products (e.g. Xanthan Gum) and have required large dilutions (e.g. PMMA). Both of these factors have made the use of these analogs unreliable and difficult to accurately construct, respectively. A new formulation is proposed that addresses the issues of solution reliability and robustness in construction. The formulation is comprised of silicon dioxide and polyalphaolefin. The former is a powder mix and the latter is a solution. The mixing quantities do not require analytical grade equipment to formulate the proper solution within an industry accepted range of error. The liquid system also exhibits a high level of clarity, which makes it compatible with imaging methods used to visualize the flow patterns of the fluid using particle image velocimetry (PIV). Presentation of the liquid system and rheological data will be delivered to support this study's conclusion that this solution is a more adequately suited blood analog for in vitro flow studies of the cardiovascular system.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125647886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad M. Kamal, Ahmed Abu Fayyad, A. Alayoubi, John F. Anderson, S. Satyanarayanajois, P. Sylvester, S. Nazzal
Summary form only given. Among two groups of components of Vitamine E, tocopherols and tocotrienols (T3), T3 shown to have anticancer property. It has been also reported that T3 potentiate the anticancer activity of some other drugs including statins when delivered simultaneously. Therefore, our study was designed to formulate a stable nanoemulsion as platform for simultaneous delivery of T3 and Simvastatin and evaluate the antiproliferative activity of the nanoemulsion against MCF-7 and MDA-MB-231 human mammary tumor cells. Nanoemuslion were prepared by high pressure homogenization where 9% w/w Simvastatin was loaded in T3 and medium chain triglyceride 70/30 blend. Mixture of primary and secondary emulsifier with DI water was used as aqueous phase. The size of the droplets was about 200nm and zeta potential was -45mV. Morphology were investigated with scanning transmission electron microscopy and found spherical or spheroidal in shape. Stability of the formulation was observed for 6 months and found stable with no loss in simvastatin loading. It has been found that, approximately 20% of Simvastatin was released in 24hrs at 37°C under sink condition. The IC50 of the T3-Simvastatin combination nanoemuslion was found 10.3 μM for MCF-7 and 4.8 μM for MDA-MB-231 cells which is significantly lower than T3 nanoemulsion which showed IC50 of 14 μM and 7 μM and Simvastatin alone which showed IC50 of 19 μM and 8 μM for MCF-7 and MDA-MB-231 cells consecutively. The present study demonstrate that, parenteral lipid nanoemulsion is a promising platform for simultaneous delivery of anticancer drugs.
{"title":"Simultaneous Delivery of Tocotrienols and Simvastatin by Lipid Nanoemulsion: A Promising Approach for Enhanced Antitumor Activity Against Human Mammary Adenocarcinoma Cells","authors":"Mohammad M. Kamal, Ahmed Abu Fayyad, A. Alayoubi, John F. Anderson, S. Satyanarayanajois, P. Sylvester, S. Nazzal","doi":"10.1109/SBEC.2016.14","DOIUrl":"https://doi.org/10.1109/SBEC.2016.14","url":null,"abstract":"Summary form only given. Among two groups of components of Vitamine E, tocopherols and tocotrienols (T3), T3 shown to have anticancer property. It has been also reported that T3 potentiate the anticancer activity of some other drugs including statins when delivered simultaneously. Therefore, our study was designed to formulate a stable nanoemulsion as platform for simultaneous delivery of T3 and Simvastatin and evaluate the antiproliferative activity of the nanoemulsion against MCF-7 and MDA-MB-231 human mammary tumor cells. Nanoemuslion were prepared by high pressure homogenization where 9% w/w Simvastatin was loaded in T3 and medium chain triglyceride 70/30 blend. Mixture of primary and secondary emulsifier with DI water was used as aqueous phase. The size of the droplets was about 200nm and zeta potential was -45mV. Morphology were investigated with scanning transmission electron microscopy and found spherical or spheroidal in shape. Stability of the formulation was observed for 6 months and found stable with no loss in simvastatin loading. It has been found that, approximately 20% of Simvastatin was released in 24hrs at 37°C under sink condition. The IC50 of the T3-Simvastatin combination nanoemuslion was found 10.3 μM for MCF-7 and 4.8 μM for MDA-MB-231 cells which is significantly lower than T3 nanoemulsion which showed IC50 of 14 μM and 7 μM and Simvastatin alone which showed IC50 of 19 μM and 8 μM for MCF-7 and MDA-MB-231 cells consecutively. The present study demonstrate that, parenteral lipid nanoemulsion is a promising platform for simultaneous delivery of anticancer drugs.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131188607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pervasive health biomedical devices are presently trending towards supplementary usage with smart phones, tablets and wearable gadgets to complement their ubiquitous roles in monitoring and diagnostic applications. In this paper, detailed design and development of a user-friendly mobile app using MIT App Inventor 2 software is explained, where emphasis is placed on building a graphical user interface (GUI) to provide the stage for real-time data acquisition and quality visualization (plotting) of photoplethysmography (PPG) data and their spectra on a smart device. Brief review of wireless networking and serial communications is also presented. PPG is modeled in a laboratory environment, where blood volume measurement is obtained via light absorption and reflectance through arterial pulse in the finger by an infrared LED source and optical sensor. A low-power microcontroller is implemented to control and digitize the analog PPG signal, characterized by a pulse oximeter waveform. Investigation of how this valuable biopotential data can be wirelessly transferred from the PPG device via a Bluetooth or WiFi module to a beaconing smart device is pursued. Following a research-driven approach and systematic process, the PPG raw data is amplified and filtered, transmitted and collected wirelessly, then further analyzed to derive the Heart Rate Variability (HRV) signal. Utilizing an advanced tool for studying the variability of heart beat intervals, namely Kubios software, the HRV data was validated for its accuracy in its computation and generation of quantitative markers indicative of the autonomic nervous system's (ANS) influence on the cardiovascular system, particularly the stress response.
{"title":"Development of Mobile Apps for Wireless Sensor Data Acquisition and Visualization of Biopotentials","authors":"Christopher Aguilar, M. Ghamari, H. Nazeran","doi":"10.1109/SBEC.2016.23","DOIUrl":"https://doi.org/10.1109/SBEC.2016.23","url":null,"abstract":"Pervasive health biomedical devices are presently trending towards supplementary usage with smart phones, tablets and wearable gadgets to complement their ubiquitous roles in monitoring and diagnostic applications. In this paper, detailed design and development of a user-friendly mobile app using MIT App Inventor 2 software is explained, where emphasis is placed on building a graphical user interface (GUI) to provide the stage for real-time data acquisition and quality visualization (plotting) of photoplethysmography (PPG) data and their spectra on a smart device. Brief review of wireless networking and serial communications is also presented. PPG is modeled in a laboratory environment, where blood volume measurement is obtained via light absorption and reflectance through arterial pulse in the finger by an infrared LED source and optical sensor. A low-power microcontroller is implemented to control and digitize the analog PPG signal, characterized by a pulse oximeter waveform. Investigation of how this valuable biopotential data can be wirelessly transferred from the PPG device via a Bluetooth or WiFi module to a beaconing smart device is pursued. Following a research-driven approach and systematic process, the PPG raw data is amplified and filtered, transmitted and collected wirelessly, then further analyzed to derive the Heart Rate Variability (HRV) signal. Utilizing an advanced tool for studying the variability of heart beat intervals, namely Kubios software, the HRV data was validated for its accuracy in its computation and generation of quantitative markers indicative of the autonomic nervous system's (ANS) influence on the cardiovascular system, particularly the stress response.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130904286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report novel synthesis for composites under physiological conditions, resulting in high-aspect ratio structures (HARS). These HARS contain copper and cystine. They are extremely stable in dry or liquid form, and have very low agglomeration. Diameters of the HARS range up from 20 nm, and length scales from nanometers to micrometers. Copper in the HARS imparts potential biological applications as copper has antimicrobial and anti-cancer effects. These HARS are degradable once interacting with cells, indicating potential new avenues for drug delivery.
{"title":"Novel Scalable Nano-and Micro-High-Aspect Ratio Structure (HARS) Biocomposites Generated under Physiological Conditions","authors":"M. DeCoster","doi":"10.1109/SBEC.2016.72","DOIUrl":"https://doi.org/10.1109/SBEC.2016.72","url":null,"abstract":"We report novel synthesis for composites under physiological conditions, resulting in high-aspect ratio structures (HARS). These HARS contain copper and cystine. They are extremely stable in dry or liquid form, and have very low agglomeration. Diameters of the HARS range up from 20 nm, and length scales from nanometers to micrometers. Copper in the HARS imparts potential biological applications as copper has antimicrobial and anti-cancer effects. These HARS are degradable once interacting with cells, indicating potential new avenues for drug delivery.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114170386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Many cofounding factors affect the health of the oral cavity. Clinicians must be aware of medications that can affect the periodontium. In addition, there must be a thorough knowledge of interactions that may be resultant due to interactions between a disease state and medications. Two of the most common infections of the oral cavity are dental caries and periodontal disease. Each alone negatively impacts the health of patients; however, in combination the effects may be detrimental. Previous studies have examined the outcomes of fibroblast morphology when exposed to the combination of dental adhesives and Nifedipine. The aim of the study was to utilize biochemical analyses as a predictor of structural alterations of fibroblasts exposed to adhesives in combination with Nifedipine and the periodontal pathogen, Porphyromonas gingivalis. The fibroblasts were exposed to 0.1g of dental adhesives (PMMA, OptiBond®, and Prime & Bond®) in combination with Porphyromonas gingivalis Lipopolysaccharide (2μL) and Nifedipine (10μL) for 48 Hours. Biocinchonic acid assay (BCA), reduced glutathione, and lactate dehydrogenase were the biochemical analyses utilized. When assessing metabolic activity, oxidative stress levels, and membrane damage, there were significant differences amongst the experimental groups compared to the control (P<;0.001). Morphological assessment was done utilizing the Hematoxylin and Eosin staining method. The experimental groups appeared similar to the control. There was no significant morphological alterations to the structural integrity of the observed fibroblasts; therefore the use of biochemical analyses was an effective predictor for structural alterations of the fibroblasts exposed to dental adhesives in combination with Nifedipine.
{"title":"Utilizing Biochemical Analyses as a Predictor for Structural Alterations of Fibroblasts Exposed to Adhesives in Combination with Nifedipine and Periodontal Pathogens","authors":"A. Garner, M. Tucci, H. Benghuzzi","doi":"10.1109/SBEC.2016.45","DOIUrl":"https://doi.org/10.1109/SBEC.2016.45","url":null,"abstract":"Many cofounding factors affect the health of the oral cavity. Clinicians must be aware of medications that can affect the periodontium. In addition, there must be a thorough knowledge of interactions that may be resultant due to interactions between a disease state and medications. Two of the most common infections of the oral cavity are dental caries and periodontal disease. Each alone negatively impacts the health of patients; however, in combination the effects may be detrimental. Previous studies have examined the outcomes of fibroblast morphology when exposed to the combination of dental adhesives and Nifedipine. The aim of the study was to utilize biochemical analyses as a predictor of structural alterations of fibroblasts exposed to adhesives in combination with Nifedipine and the periodontal pathogen, Porphyromonas gingivalis. The fibroblasts were exposed to 0.1g of dental adhesives (PMMA, OptiBond®, and Prime & Bond®) in combination with Porphyromonas gingivalis Lipopolysaccharide (2μL) and Nifedipine (10μL) for 48 Hours. Biocinchonic acid assay (BCA), reduced glutathione, and lactate dehydrogenase were the biochemical analyses utilized. When assessing metabolic activity, oxidative stress levels, and membrane damage, there were significant differences amongst the experimental groups compared to the control (P<;0.001). Morphological assessment was done utilizing the Hematoxylin and Eosin staining method. The experimental groups appeared similar to the control. There was no significant morphological alterations to the structural integrity of the observed fibroblasts; therefore the use of biochemical analyses was an effective predictor for structural alterations of the fibroblasts exposed to dental adhesives in combination with Nifedipine.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129711953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Do Yeon Kim, Jong-Hoon Kim, M. Prabakar, YoungJin Jung
Summary form only given. Due to raised incidences of stroke, paralysis, or other diseases along with dramatic increment of life expectancy, the number of patients with movement disability has been increasing continuously. Repetitive and intensive voluntary movements in physical therapy are important factors that facilitate significant improvement for motor-impaired patients. The emergence of rehabilitation robotic devices has stimulated the development of physical therapy. However, most of current robotic devices for upper limb are poor in user-friendly interface and bulky as well as assisting only limited part(s) of arm. We proposed Smart Portable Rehabilitation Exoskeletal Device (SPRED), which is a portable, tele-operatable, and effective exoskeleton type of upper limb rehabilitation robotic device controlled by multimodal signals with smart interfaces for both patients and therapists. The SPRED system supports full range of joint movements and assists disabled arms more naturally through highly accurate, adaptable, and fast responses based on muscle strength, brain activity, and motion tracking technology. The compact size and wireless device allows patients to carry the device during their daily activities so that they can naturally lengthen the training duration and conclude more effective clinical results eventually. We believe that the research will contribute to development a new generation of exoskeleton type of rehabilitation robotic device for upper limb. As a first step towards the proposed system, this paper presents the design of SPRED and the mirroring motion based self-tuning concept is illustrated. Its simulation result demonstrates its potential in upper limb rehabilitation.
{"title":"Design of Smart Portable Rehabilitation Exoskeletal Device for Upper Limb","authors":"Do Yeon Kim, Jong-Hoon Kim, M. Prabakar, YoungJin Jung","doi":"10.1109/SBEC.2016.97","DOIUrl":"https://doi.org/10.1109/SBEC.2016.97","url":null,"abstract":"Summary form only given. Due to raised incidences of stroke, paralysis, or other diseases along with dramatic increment of life expectancy, the number of patients with movement disability has been increasing continuously. Repetitive and intensive voluntary movements in physical therapy are important factors that facilitate significant improvement for motor-impaired patients. The emergence of rehabilitation robotic devices has stimulated the development of physical therapy. However, most of current robotic devices for upper limb are poor in user-friendly interface and bulky as well as assisting only limited part(s) of arm. We proposed Smart Portable Rehabilitation Exoskeletal Device (SPRED), which is a portable, tele-operatable, and effective exoskeleton type of upper limb rehabilitation robotic device controlled by multimodal signals with smart interfaces for both patients and therapists. The SPRED system supports full range of joint movements and assists disabled arms more naturally through highly accurate, adaptable, and fast responses based on muscle strength, brain activity, and motion tracking technology. The compact size and wireless device allows patients to carry the device during their daily activities so that they can naturally lengthen the training duration and conclude more effective clinical results eventually. We believe that the research will contribute to development a new generation of exoskeleton type of rehabilitation robotic device for upper limb. As a first step towards the proposed system, this paper presents the design of SPRED and the mirroring motion based self-tuning concept is illustrated. Its simulation result demonstrates its potential in upper limb rehabilitation.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130540080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fused deposition modeling (FDM) printers are becoming more frequent in everyday use. These types of 3D printers are extremely useful for rapid prototyping. Fused deposition modeling printing melts the printing material and extrudes it through a nozzle. The material is laid out in a layer by layer fashion until the object is completed printing. Two common types of filament used in FDM printing are Polylactic Acid (PLA) and Acrylonitrile butadiene styrene (ABS). Some properties that can change the strength of 3D printed piece are things such as infill percentage, layer height, print orientation, extruding temperature, and build speed to name a few. Infill percentage and print orientation were tested to determine the mechanical strength of the material. The infill percentage varied from 20%-100% by increments of 20%. The goal of this project was to analyze the mechanical strength of PLA being printed in various orientations and infill percentages.
{"title":"Mechanical Strength of 3-D Printed Filaments","authors":"Francois Decuir, Kelsey Phelan, B. C. Hollins","doi":"10.1109/SBEC.2016.101","DOIUrl":"https://doi.org/10.1109/SBEC.2016.101","url":null,"abstract":"Fused deposition modeling (FDM) printers are becoming more frequent in everyday use. These types of 3D printers are extremely useful for rapid prototyping. Fused deposition modeling printing melts the printing material and extrudes it through a nozzle. The material is laid out in a layer by layer fashion until the object is completed printing. Two common types of filament used in FDM printing are Polylactic Acid (PLA) and Acrylonitrile butadiene styrene (ABS). Some properties that can change the strength of 3D printed piece are things such as infill percentage, layer height, print orientation, extruding temperature, and build speed to name a few. Infill percentage and print orientation were tested to determine the mechanical strength of the material. The infill percentage varied from 20%-100% by increments of 20%. The goal of this project was to analyze the mechanical strength of PLA being printed in various orientations and infill percentages.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129099674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Kokkinis, M. Phan, H. Srikanth, S. Cardoso, I. Giouroudi
In this paper we present a novel, multiplex, portable microfluidic biosensor for real-time detection and quantification of biomolecules, such as proteins, antibodies, DNA strands and anti-cancer drugs conjugated with Fe3O4 nanoparticles. We show that quantification hands-on time is reduced, and sample throughput can be increased using automation and efficient data evaluation with the appropriate LabVIEW software. Experiments were carried out using Fe3O4 nanoparticles coated with Poly(lacticacid), PEG and Curcumin as a proof of concept.
{"title":"Magnetic Microfluidic Biosensor for the Detection and Quantification of Biomolecules","authors":"G. Kokkinis, M. Phan, H. Srikanth, S. Cardoso, I. Giouroudi","doi":"10.1109/SBEC.2016.13","DOIUrl":"https://doi.org/10.1109/SBEC.2016.13","url":null,"abstract":"In this paper we present a novel, multiplex, portable microfluidic biosensor for real-time detection and quantification of biomolecules, such as proteins, antibodies, DNA strands and anti-cancer drugs conjugated with Fe3O4 nanoparticles. We show that quantification hands-on time is reduced, and sample throughput can be increased using automation and efficient data evaluation with the appropriate LabVIEW software. Experiments were carried out using Fe3O4 nanoparticles coated with Poly(lacticacid), PEG and Curcumin as a proof of concept.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122287934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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