Kyle Farmer, Lauren R. Molaison, Kinzie Leblanc, Clint A. Bergeron, Charles E. Taylor
The creation of anatomical computer aided design (CAD) models in the effort to replicate in vivo tissue geometry has been used in order to further study the implications of diseases and flow conditions in the region of the aortic valve. With medical imaging data, (e.g. CT, MRI, ultrasound), it is possible to create a three-dimensional (3-D) anatomical model by using lofted surfaces to represent the anatomy. This method makes the model more compatible with the intended simulation and fabrication techniques. Utilizing additive manufacturing techniques, dissolvable molds were developed so that the resulting anatomical models could be cast from Sylgard 184 silicone. The custom housing for the model was developed to replicate the conditions in which the real-life version of the model would be exposed to, and create a viewing window in which this simulated model can be observed. A camera array system and LED based lighting solution has been used for the measurement of the models performance during in vitro testing. Use of MathWorks Computer System Vision Toolbox was employed to process the image data and calculate the displacement of the silicone models. A discourse on the method of creation of the model and the housing in which the model was tested will be provided. The data obtained from this simulated model will further understanding of the anatomy of biological structures and biomechanics while under the pathophysiological conditions that have resulted from the progression various diseases and surgical interventions.
{"title":"Development of a Parametric Aortic Valve CAD Model, Fabrication of Testing Samples, and Strategy for in vitro Measurement","authors":"Kyle Farmer, Lauren R. Molaison, Kinzie Leblanc, Clint A. Bergeron, Charles E. Taylor","doi":"10.1109/SBEC.2016.56","DOIUrl":"https://doi.org/10.1109/SBEC.2016.56","url":null,"abstract":"The creation of anatomical computer aided design (CAD) models in the effort to replicate in vivo tissue geometry has been used in order to further study the implications of diseases and flow conditions in the region of the aortic valve. With medical imaging data, (e.g. CT, MRI, ultrasound), it is possible to create a three-dimensional (3-D) anatomical model by using lofted surfaces to represent the anatomy. This method makes the model more compatible with the intended simulation and fabrication techniques. Utilizing additive manufacturing techniques, dissolvable molds were developed so that the resulting anatomical models could be cast from Sylgard 184 silicone. The custom housing for the model was developed to replicate the conditions in which the real-life version of the model would be exposed to, and create a viewing window in which this simulated model can be observed. A camera array system and LED based lighting solution has been used for the measurement of the models performance during in vitro testing. Use of MathWorks Computer System Vision Toolbox was employed to process the image data and calculate the displacement of the silicone models. A discourse on the method of creation of the model and the housing in which the model was tested will be provided. The data obtained from this simulated model will further understanding of the anatomy of biological structures and biomechanics while under the pathophysiological conditions that have resulted from the progression various diseases and surgical interventions.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122227827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Kokkinis, M. Phan, H. Srikanth, S. Cardoso, I. Giouroudi
In this paper we present a novel, multiplex, portable microfluidic biosensor for real-time detection and quantification of biomolecules, such as proteins, antibodies, DNA strands and anti-cancer drugs conjugated with Fe3O4 nanoparticles. We show that quantification hands-on time is reduced, and sample throughput can be increased using automation and efficient data evaluation with the appropriate LabVIEW software. Experiments were carried out using Fe3O4 nanoparticles coated with Poly(lacticacid), PEG and Curcumin as a proof of concept.
{"title":"Magnetic Microfluidic Biosensor for the Detection and Quantification of Biomolecules","authors":"G. Kokkinis, M. Phan, H. Srikanth, S. Cardoso, I. Giouroudi","doi":"10.1109/SBEC.2016.13","DOIUrl":"https://doi.org/10.1109/SBEC.2016.13","url":null,"abstract":"In this paper we present a novel, multiplex, portable microfluidic biosensor for real-time detection and quantification of biomolecules, such as proteins, antibodies, DNA strands and anti-cancer drugs conjugated with Fe3O4 nanoparticles. We show that quantification hands-on time is reduced, and sample throughput can be increased using automation and efficient data evaluation with the appropriate LabVIEW software. Experiments were carried out using Fe3O4 nanoparticles coated with Poly(lacticacid), PEG and Curcumin as a proof of concept.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122287934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Applications of Medical imaging in clinical diagnostics and image-guided surgery have been increasing at rapid rates. This contributes greater demand for BME graduates including the ones at undergraduate level. It appears medical imaging is not taught at the undergraduate level at many BME programs, thus triggering the need to consider developing an appropriate undergraduate medical imaging and optics course. Teaching undergraduate level medical imaging and optics is more challenging compared to the one at the graduate level due to unavailability of proper level textbooks, lab modules and equipment accessibility. This paper features the theoretical segments taught in such a course and highlights the pedagogy and techniques used to teach a medical imaging and optics course in undergraduate BME programs, as well as the interesting projects and other course requirements associated with it.
{"title":"Introducing Medical Imaging and Optics Course in Undergraduate BME Program","authors":"J. Shahbazian, K. Shankar","doi":"10.1109/SBEC.2016.18","DOIUrl":"https://doi.org/10.1109/SBEC.2016.18","url":null,"abstract":"Applications of Medical imaging in clinical diagnostics and image-guided surgery have been increasing at rapid rates. This contributes greater demand for BME graduates including the ones at undergraduate level. It appears medical imaging is not taught at the undergraduate level at many BME programs, thus triggering the need to consider developing an appropriate undergraduate medical imaging and optics course. Teaching undergraduate level medical imaging and optics is more challenging compared to the one at the graduate level due to unavailability of proper level textbooks, lab modules and equipment accessibility. This paper features the theoretical segments taught in such a course and highlights the pedagogy and techniques used to teach a medical imaging and optics course in undergraduate BME programs, as well as the interesting projects and other course requirements associated with it.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124194341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Do Yeon Kim, Jong-Hoon Kim, M. Prabakar, YoungJin Jung
Summary form only given. Due to raised incidences of stroke, paralysis, or other diseases along with dramatic increment of life expectancy, the number of patients with movement disability has been increasing continuously. Repetitive and intensive voluntary movements in physical therapy are important factors that facilitate significant improvement for motor-impaired patients. The emergence of rehabilitation robotic devices has stimulated the development of physical therapy. However, most of current robotic devices for upper limb are poor in user-friendly interface and bulky as well as assisting only limited part(s) of arm. We proposed Smart Portable Rehabilitation Exoskeletal Device (SPRED), which is a portable, tele-operatable, and effective exoskeleton type of upper limb rehabilitation robotic device controlled by multimodal signals with smart interfaces for both patients and therapists. The SPRED system supports full range of joint movements and assists disabled arms more naturally through highly accurate, adaptable, and fast responses based on muscle strength, brain activity, and motion tracking technology. The compact size and wireless device allows patients to carry the device during their daily activities so that they can naturally lengthen the training duration and conclude more effective clinical results eventually. We believe that the research will contribute to development a new generation of exoskeleton type of rehabilitation robotic device for upper limb. As a first step towards the proposed system, this paper presents the design of SPRED and the mirroring motion based self-tuning concept is illustrated. Its simulation result demonstrates its potential in upper limb rehabilitation.
{"title":"Design of Smart Portable Rehabilitation Exoskeletal Device for Upper Limb","authors":"Do Yeon Kim, Jong-Hoon Kim, M. Prabakar, YoungJin Jung","doi":"10.1109/SBEC.2016.97","DOIUrl":"https://doi.org/10.1109/SBEC.2016.97","url":null,"abstract":"Summary form only given. Due to raised incidences of stroke, paralysis, or other diseases along with dramatic increment of life expectancy, the number of patients with movement disability has been increasing continuously. Repetitive and intensive voluntary movements in physical therapy are important factors that facilitate significant improvement for motor-impaired patients. The emergence of rehabilitation robotic devices has stimulated the development of physical therapy. However, most of current robotic devices for upper limb are poor in user-friendly interface and bulky as well as assisting only limited part(s) of arm. We proposed Smart Portable Rehabilitation Exoskeletal Device (SPRED), which is a portable, tele-operatable, and effective exoskeleton type of upper limb rehabilitation robotic device controlled by multimodal signals with smart interfaces for both patients and therapists. The SPRED system supports full range of joint movements and assists disabled arms more naturally through highly accurate, adaptable, and fast responses based on muscle strength, brain activity, and motion tracking technology. The compact size and wireless device allows patients to carry the device during their daily activities so that they can naturally lengthen the training duration and conclude more effective clinical results eventually. We believe that the research will contribute to development a new generation of exoskeleton type of rehabilitation robotic device for upper limb. As a first step towards the proposed system, this paper presents the design of SPRED and the mirroring motion based self-tuning concept is illustrated. Its simulation result demonstrates its potential in upper limb rehabilitation.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130540080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.
{"title":"Subcutaneous Fibroblast Migration is Altered by Amino Acid Coated UHMW-PE Implants","authors":"K. Butler, H. Benghuzzi, M. Tucci, A. Puckett","doi":"10.1109/SBEC.2016.10","DOIUrl":"https://doi.org/10.1109/SBEC.2016.10","url":null,"abstract":"The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130023555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary form only given. Cardiovascular disease is the leading cause of death in the United States, killing at least 787,000 people every year. Similarly, more than 200 million people worldwide are affected by Peripheral Artery Disease (PAD), which causes atherosclerosis in the lowerextremity arteries. Atherosclerosis of the periphery is a problem that is very underdiagnosed and undertreated by the medical community. Currently, it is known that vascular interventional procedures, in particular stents, fail to treat PAD due to stent fracture caused by bending, torsion and axial forces of periphery arteries. Furthermore, the impact of these forces on regenerating cells and newer interventional procedures such as drug coated balloons and other non-stent platforms remains unknown. For this reason, the aim of this work was to design a bench-top bioreactor system to mimic the dynamic environment of peripheral arteries. A system compromised of motors and a holding chamber unit was developed to house freshly harvested arteries and expose the vessel to twisting and axial forces within a culture incubator. The developed bioreactor system will thus be used to study the impact of arterial mechanical deformation on current and next generation interventional devices.
{"title":"Design of a Bench-Top Bioreactor System to Mimic the Dynamic Environment of Peripheral Arteries","authors":"Jesus Estaba, S. Yazdani","doi":"10.1109/SBEC.2016.35","DOIUrl":"https://doi.org/10.1109/SBEC.2016.35","url":null,"abstract":"Summary form only given. Cardiovascular disease is the leading cause of death in the United States, killing at least 787,000 people every year. Similarly, more than 200 million people worldwide are affected by Peripheral Artery Disease (PAD), which causes atherosclerosis in the lowerextremity arteries. Atherosclerosis of the periphery is a problem that is very underdiagnosed and undertreated by the medical community. Currently, it is known that vascular interventional procedures, in particular stents, fail to treat PAD due to stent fracture caused by bending, torsion and axial forces of periphery arteries. Furthermore, the impact of these forces on regenerating cells and newer interventional procedures such as drug coated balloons and other non-stent platforms remains unknown. For this reason, the aim of this work was to design a bench-top bioreactor system to mimic the dynamic environment of peripheral arteries. A system compromised of motors and a holding chamber unit was developed to house freshly harvested arteries and expose the vessel to twisting and axial forces within a culture incubator. The developed bioreactor system will thus be used to study the impact of arterial mechanical deformation on current and next generation interventional devices.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130980071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the blood-brain barrier (BBB). The main functions of this barrier are maintenance of brain homeostasis, regulation of influx and efflux transport, and protection from harmful circulating endogenous and exogenous neurotoxins. These functions are determined by the BBB specialized multicellular structure. Every constituent cell type makes an indispensable contribution to the BBB integrity. Several reports indicated that the BBB is compromised in Alzheimer's disease (AD) which affects its integrity and functional activity. Furthermore, these changes in the BBB correlated well with dysfunction in the clearance of Aß across the BBB and formation of Aß plaques. Several hit compounds that were able to enhance the BBB integrity were identified from the high-throughput screening assay developed in our laboratory. Among these compounds etodolac, an NSAID drug, has shown to enhance the BBB model integrity measured by its ability to decrease the paracellular permeability markers Lucifer Yellow and inulin. Moreover, our data suggested that etodolac enhanced the active transport of amyloid-beta (Aß42) across the BBB model. In conclusion, the NSAID etodolac could be a promising drug for the treatment of Alzheimer's disease. In vivo studies are in progress to investigate etodolac effect in AD mouse model.
{"title":"Etodolac Enhances the Blood-Brain Barrier Integrity and Clearance of Amyloid-Beta","authors":"Khaled H. Elfakhri, J. Keller, A. Kaddoumi","doi":"10.1109/SBEC.2016.74","DOIUrl":"https://doi.org/10.1109/SBEC.2016.74","url":null,"abstract":"The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the blood-brain barrier (BBB). The main functions of this barrier are maintenance of brain homeostasis, regulation of influx and efflux transport, and protection from harmful circulating endogenous and exogenous neurotoxins. These functions are determined by the BBB specialized multicellular structure. Every constituent cell type makes an indispensable contribution to the BBB integrity. Several reports indicated that the BBB is compromised in Alzheimer's disease (AD) which affects its integrity and functional activity. Furthermore, these changes in the BBB correlated well with dysfunction in the clearance of Aß across the BBB and formation of Aß plaques. Several hit compounds that were able to enhance the BBB integrity were identified from the high-throughput screening assay developed in our laboratory. Among these compounds etodolac, an NSAID drug, has shown to enhance the BBB model integrity measured by its ability to decrease the paracellular permeability markers Lucifer Yellow and inulin. Moreover, our data suggested that etodolac enhanced the active transport of amyloid-beta (Aß42) across the BBB model. In conclusion, the NSAID etodolac could be a promising drug for the treatment of Alzheimer's disease. In vivo studies are in progress to investigate etodolac effect in AD mouse model.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133663302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Richard, Ryan Jeansonne, J. Hebert, G. Stoute, Jacob M. King, Charles E. Taylor
Typical in vitro analysis of medical device performance occurs at room temperature (~70 degrees Fahrenheit). Effective evaluation requires at temperature studies for blood contacting medical devices for the following purposes: wear characteristics, thermal expansion, and temperature effects on sensors in the design. The task was to control the fluid within an ISO5198 hydraulic loop used to evaluate left ventricular assist devices at a given temperature between 95F and 105F. The design was to function within one degree Fahrenheit. This task was accomplished utilizing a microcontroller, the PowerSwitch Tail II, a DS18B20 waterproof temperature sensor, and an immersion heater. To manage heat loss from the piping section of the loop foam piping insulation was installed to all non-testing sections. The group was able to successfully thermally regulate temperature in the loop for a range of flow rates (2-10 LPM). The team utilized a pulsing control architecture to keep overshoot within the system to a minimum. The system takes approximately 6 mins to come to temperature with approximately a one degree overshoot. The longest recorded success of controlling the loop within a plus or minus one degree accuracy is approximately 2 hours. A computational model of the system was made using the thermofluid blocks of the Simulink Simscape foundation library. Approximated heat loss is roughly 70 W for the entire circuit, which equates to one degree Fahrenheit drop for every five minutes without heat input. The result of this design is a cost effective means of producing reflective in vivo thermal conditions.
{"title":"Thermal Management System for In Vitro Evalution of Circulatory Assist Devices at In Vivo Temperatures","authors":"J. Richard, Ryan Jeansonne, J. Hebert, G. Stoute, Jacob M. King, Charles E. Taylor","doi":"10.1109/SBEC.2016.85","DOIUrl":"https://doi.org/10.1109/SBEC.2016.85","url":null,"abstract":"Typical in vitro analysis of medical device performance occurs at room temperature (~70 degrees Fahrenheit). Effective evaluation requires at temperature studies for blood contacting medical devices for the following purposes: wear characteristics, thermal expansion, and temperature effects on sensors in the design. The task was to control the fluid within an ISO5198 hydraulic loop used to evaluate left ventricular assist devices at a given temperature between 95F and 105F. The design was to function within one degree Fahrenheit. This task was accomplished utilizing a microcontroller, the PowerSwitch Tail II, a DS18B20 waterproof temperature sensor, and an immersion heater. To manage heat loss from the piping section of the loop foam piping insulation was installed to all non-testing sections. The group was able to successfully thermally regulate temperature in the loop for a range of flow rates (2-10 LPM). The team utilized a pulsing control architecture to keep overshoot within the system to a minimum. The system takes approximately 6 mins to come to temperature with approximately a one degree overshoot. The longest recorded success of controlling the loop within a plus or minus one degree accuracy is approximately 2 hours. A computational model of the system was made using the thermofluid blocks of the Simulink Simscape foundation library. Approximated heat loss is roughly 70 W for the entire circuit, which equates to one degree Fahrenheit drop for every five minutes without heat input. The result of this design is a cost effective means of producing reflective in vivo thermal conditions.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114326757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previous experiments have documented the discovery of novel high-aspect ratio structures (HARS) composed of cystine and copper synthesized in a physiological environment. These HARS scale in size from nano to micro dimensions and have favorable properties such as biocompatibility, long-term stability, and non-agglomerating properties. Here we tested for: optimal synthesis conditions, stability limits, and their application to uniformly coat films. Because the HARS have an amino acid component, functionalization using layer-by-layer techniques may provide strategies for improved imaging, masking, and ordering the structures for controlled interaction with cells in 2d and 3d spaces.
{"title":"Synthesis and Post-Synthesis Optimization of Novel Copper Biocomposites and Exploration of Potential Applications","authors":"David L. Milam, S. Deodhar, M. DeCoster","doi":"10.1109/SBEC.2016.76","DOIUrl":"https://doi.org/10.1109/SBEC.2016.76","url":null,"abstract":"Previous experiments have documented the discovery of novel high-aspect ratio structures (HARS) composed of cystine and copper synthesized in a physiological environment. These HARS scale in size from nano to micro dimensions and have favorable properties such as biocompatibility, long-term stability, and non-agglomerating properties. Here we tested for: optimal synthesis conditions, stability limits, and their application to uniformly coat films. Because the HARS have an amino acid component, functionalization using layer-by-layer techniques may provide strategies for improved imaging, masking, and ordering the structures for controlled interaction with cells in 2d and 3d spaces.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124620975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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