Kyle Farmer, Lauren R. Molaison, Kinzie Leblanc, Clint A. Bergeron, Charles E. Taylor
The creation of anatomical computer aided design (CAD) models in the effort to replicate in vivo tissue geometry has been used in order to further study the implications of diseases and flow conditions in the region of the aortic valve. With medical imaging data, (e.g. CT, MRI, ultrasound), it is possible to create a three-dimensional (3-D) anatomical model by using lofted surfaces to represent the anatomy. This method makes the model more compatible with the intended simulation and fabrication techniques. Utilizing additive manufacturing techniques, dissolvable molds were developed so that the resulting anatomical models could be cast from Sylgard 184 silicone. The custom housing for the model was developed to replicate the conditions in which the real-life version of the model would be exposed to, and create a viewing window in which this simulated model can be observed. A camera array system and LED based lighting solution has been used for the measurement of the models performance during in vitro testing. Use of MathWorks Computer System Vision Toolbox was employed to process the image data and calculate the displacement of the silicone models. A discourse on the method of creation of the model and the housing in which the model was tested will be provided. The data obtained from this simulated model will further understanding of the anatomy of biological structures and biomechanics while under the pathophysiological conditions that have resulted from the progression various diseases and surgical interventions.
{"title":"Development of a Parametric Aortic Valve CAD Model, Fabrication of Testing Samples, and Strategy for in vitro Measurement","authors":"Kyle Farmer, Lauren R. Molaison, Kinzie Leblanc, Clint A. Bergeron, Charles E. Taylor","doi":"10.1109/SBEC.2016.56","DOIUrl":"https://doi.org/10.1109/SBEC.2016.56","url":null,"abstract":"The creation of anatomical computer aided design (CAD) models in the effort to replicate in vivo tissue geometry has been used in order to further study the implications of diseases and flow conditions in the region of the aortic valve. With medical imaging data, (e.g. CT, MRI, ultrasound), it is possible to create a three-dimensional (3-D) anatomical model by using lofted surfaces to represent the anatomy. This method makes the model more compatible with the intended simulation and fabrication techniques. Utilizing additive manufacturing techniques, dissolvable molds were developed so that the resulting anatomical models could be cast from Sylgard 184 silicone. The custom housing for the model was developed to replicate the conditions in which the real-life version of the model would be exposed to, and create a viewing window in which this simulated model can be observed. A camera array system and LED based lighting solution has been used for the measurement of the models performance during in vitro testing. Use of MathWorks Computer System Vision Toolbox was employed to process the image data and calculate the displacement of the silicone models. A discourse on the method of creation of the model and the housing in which the model was tested will be provided. The data obtained from this simulated model will further understanding of the anatomy of biological structures and biomechanics while under the pathophysiological conditions that have resulted from the progression various diseases and surgical interventions.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122227827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer D. Thibodeaux, Ronnie W. Kisor, Jacob M. King, Charles E. Taylor
Summary form only given. The highly pulsatile flow conditions in the arch of aorta and the branching nature of this anatomy create a complex flow regime that catheter-based surgical devices and left heart medical devices may impact. Disturbance of flow to the carotid arteries, which lead to the brain, may result in hypoxic conditions or elevated blood pressure that may result in stroke. The severity of these issues necessitates a practical means of replicating the flow rate in the bifurcations of the aorta, within a mock circulatory system (MCS). In this research, this problem was addressed by analyzing the effects of precisely controlling a series of four pinch valves in order to replicate the blood flow in the branches of the aorta and into the brachial and carotid arteries. Following a verification and validation (V&V) methodology, a PID controlled, closed loop, hydraulic system was created using Simulink® SimscapeTM. Subsequently, empirical testing of this method was conducted in a benchtop hydraulic loop with a 3D printed arch of aorta. Utilizing this approach, the flow rate through the branching arteries were controlled, via a microcontroller. The pressure differential across each pinch valve was characterized with respect to the position of the pinch valve, providing data which allowed the flow rate to be determined in run time for both steady state settings, as well as time variant conditions. Empirical verification of the aortic bifurcation simulator's performance and validation of the control architecture support this methodology as an effective means of reproducing the complex dynamics of aortic flow.
{"title":"Flow Control Device for Branching Arteries of the Aortic Arch in a Mock Circulatory Loop","authors":"Jennifer D. Thibodeaux, Ronnie W. Kisor, Jacob M. King, Charles E. Taylor","doi":"10.1109/SBEC.2016.51","DOIUrl":"https://doi.org/10.1109/SBEC.2016.51","url":null,"abstract":"Summary form only given. The highly pulsatile flow conditions in the arch of aorta and the branching nature of this anatomy create a complex flow regime that catheter-based surgical devices and left heart medical devices may impact. Disturbance of flow to the carotid arteries, which lead to the brain, may result in hypoxic conditions or elevated blood pressure that may result in stroke. The severity of these issues necessitates a practical means of replicating the flow rate in the bifurcations of the aorta, within a mock circulatory system (MCS). In this research, this problem was addressed by analyzing the effects of precisely controlling a series of four pinch valves in order to replicate the blood flow in the branches of the aorta and into the brachial and carotid arteries. Following a verification and validation (V&V) methodology, a PID controlled, closed loop, hydraulic system was created using Simulink® SimscapeTM. Subsequently, empirical testing of this method was conducted in a benchtop hydraulic loop with a 3D printed arch of aorta. Utilizing this approach, the flow rate through the branching arteries were controlled, via a microcontroller. The pressure differential across each pinch valve was characterized with respect to the position of the pinch valve, providing data which allowed the flow rate to be determined in run time for both steady state settings, as well as time variant conditions. Empirical verification of the aortic bifurcation simulator's performance and validation of the control architecture support this methodology as an effective means of reproducing the complex dynamics of aortic flow.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128933055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Applications of Medical imaging in clinical diagnostics and image-guided surgery have been increasing at rapid rates. This contributes greater demand for BME graduates including the ones at undergraduate level. It appears medical imaging is not taught at the undergraduate level at many BME programs, thus triggering the need to consider developing an appropriate undergraduate medical imaging and optics course. Teaching undergraduate level medical imaging and optics is more challenging compared to the one at the graduate level due to unavailability of proper level textbooks, lab modules and equipment accessibility. This paper features the theoretical segments taught in such a course and highlights the pedagogy and techniques used to teach a medical imaging and optics course in undergraduate BME programs, as well as the interesting projects and other course requirements associated with it.
{"title":"Introducing Medical Imaging and Optics Course in Undergraduate BME Program","authors":"J. Shahbazian, K. Shankar","doi":"10.1109/SBEC.2016.18","DOIUrl":"https://doi.org/10.1109/SBEC.2016.18","url":null,"abstract":"Applications of Medical imaging in clinical diagnostics and image-guided surgery have been increasing at rapid rates. This contributes greater demand for BME graduates including the ones at undergraduate level. It appears medical imaging is not taught at the undergraduate level at many BME programs, thus triggering the need to consider developing an appropriate undergraduate medical imaging and optics course. Teaching undergraduate level medical imaging and optics is more challenging compared to the one at the graduate level due to unavailability of proper level textbooks, lab modules and equipment accessibility. This paper features the theoretical segments taught in such a course and highlights the pedagogy and techniques used to teach a medical imaging and optics course in undergraduate BME programs, as well as the interesting projects and other course requirements associated with it.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124194341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasan Siddiqui, J. Jimenez-shahed, A. Viswanathan, N. Ince
Deep brain stimulation (DBS) surgery involves placing an electrode in the subthalamic nucleus to suppress the motor symptoms, such as tremor, of patients with Parkinson's disease (PD). Currently physicians use the standard Unified Parkinson's Disease Rating Scale (UPDRS) to describe the tremor intraoperatively and post operatively. This scale involves subjective anchor-based observations by the clinical expert. In this study, a wireless accelerometer system is presented that was built from off the shelf components to objectively quantify tremor scores. The system consists of a Teensy 3.1 microcontroller and two 3-axis accelerometers. It wirelessly transmits the readings through a Bluetooth module. The data is received by a custom C++ program that parses and transmits the data. The system is used to record data from patients with PD during and after DBS surgery. We show example data recorded from several PD patients and study the correlation of sensor readings with the DBS ON and OFF states. We provide initial data showing that such a system can be effectively used in the clinic for the objective quantification of motor symptoms of PD patients.
{"title":"A Wireless Sensor Interface for the Quantification of Tremor Using Off the Shelf Components","authors":"Hasan Siddiqui, J. Jimenez-shahed, A. Viswanathan, N. Ince","doi":"10.1109/SBEC.2016.63","DOIUrl":"https://doi.org/10.1109/SBEC.2016.63","url":null,"abstract":"Deep brain stimulation (DBS) surgery involves placing an electrode in the subthalamic nucleus to suppress the motor symptoms, such as tremor, of patients with Parkinson's disease (PD). Currently physicians use the standard Unified Parkinson's Disease Rating Scale (UPDRS) to describe the tremor intraoperatively and post operatively. This scale involves subjective anchor-based observations by the clinical expert. In this study, a wireless accelerometer system is presented that was built from off the shelf components to objectively quantify tremor scores. The system consists of a Teensy 3.1 microcontroller and two 3-axis accelerometers. It wirelessly transmits the readings through a Bluetooth module. The data is received by a custom C++ program that parses and transmits the data. The system is used to record data from patients with PD during and after DBS surgery. We show example data recorded from several PD patients and study the correlation of sensor readings with the DBS ON and OFF states. We provide initial data showing that such a system can be effectively used in the clinic for the objective quantification of motor symptoms of PD patients.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127217755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.
{"title":"Subcutaneous Fibroblast Migration is Altered by Amino Acid Coated UHMW-PE Implants","authors":"K. Butler, H. Benghuzzi, M. Tucci, A. Puckett","doi":"10.1109/SBEC.2016.10","DOIUrl":"https://doi.org/10.1109/SBEC.2016.10","url":null,"abstract":"The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130023555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary form only given. Cardiovascular disease is the leading cause of death in the United States, killing at least 787,000 people every year. Similarly, more than 200 million people worldwide are affected by Peripheral Artery Disease (PAD), which causes atherosclerosis in the lowerextremity arteries. Atherosclerosis of the periphery is a problem that is very underdiagnosed and undertreated by the medical community. Currently, it is known that vascular interventional procedures, in particular stents, fail to treat PAD due to stent fracture caused by bending, torsion and axial forces of periphery arteries. Furthermore, the impact of these forces on regenerating cells and newer interventional procedures such as drug coated balloons and other non-stent platforms remains unknown. For this reason, the aim of this work was to design a bench-top bioreactor system to mimic the dynamic environment of peripheral arteries. A system compromised of motors and a holding chamber unit was developed to house freshly harvested arteries and expose the vessel to twisting and axial forces within a culture incubator. The developed bioreactor system will thus be used to study the impact of arterial mechanical deformation on current and next generation interventional devices.
{"title":"Design of a Bench-Top Bioreactor System to Mimic the Dynamic Environment of Peripheral Arteries","authors":"Jesus Estaba, S. Yazdani","doi":"10.1109/SBEC.2016.35","DOIUrl":"https://doi.org/10.1109/SBEC.2016.35","url":null,"abstract":"Summary form only given. Cardiovascular disease is the leading cause of death in the United States, killing at least 787,000 people every year. Similarly, more than 200 million people worldwide are affected by Peripheral Artery Disease (PAD), which causes atherosclerosis in the lowerextremity arteries. Atherosclerosis of the periphery is a problem that is very underdiagnosed and undertreated by the medical community. Currently, it is known that vascular interventional procedures, in particular stents, fail to treat PAD due to stent fracture caused by bending, torsion and axial forces of periphery arteries. Furthermore, the impact of these forces on regenerating cells and newer interventional procedures such as drug coated balloons and other non-stent platforms remains unknown. For this reason, the aim of this work was to design a bench-top bioreactor system to mimic the dynamic environment of peripheral arteries. A system compromised of motors and a holding chamber unit was developed to house freshly harvested arteries and expose the vessel to twisting and axial forces within a culture incubator. The developed bioreactor system will thus be used to study the impact of arterial mechanical deformation on current and next generation interventional devices.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130980071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the blood-brain barrier (BBB). The main functions of this barrier are maintenance of brain homeostasis, regulation of influx and efflux transport, and protection from harmful circulating endogenous and exogenous neurotoxins. These functions are determined by the BBB specialized multicellular structure. Every constituent cell type makes an indispensable contribution to the BBB integrity. Several reports indicated that the BBB is compromised in Alzheimer's disease (AD) which affects its integrity and functional activity. Furthermore, these changes in the BBB correlated well with dysfunction in the clearance of Aß across the BBB and formation of Aß plaques. Several hit compounds that were able to enhance the BBB integrity were identified from the high-throughput screening assay developed in our laboratory. Among these compounds etodolac, an NSAID drug, has shown to enhance the BBB model integrity measured by its ability to decrease the paracellular permeability markers Lucifer Yellow and inulin. Moreover, our data suggested that etodolac enhanced the active transport of amyloid-beta (Aß42) across the BBB model. In conclusion, the NSAID etodolac could be a promising drug for the treatment of Alzheimer's disease. In vivo studies are in progress to investigate etodolac effect in AD mouse model.
{"title":"Etodolac Enhances the Blood-Brain Barrier Integrity and Clearance of Amyloid-Beta","authors":"Khaled H. Elfakhri, J. Keller, A. Kaddoumi","doi":"10.1109/SBEC.2016.74","DOIUrl":"https://doi.org/10.1109/SBEC.2016.74","url":null,"abstract":"The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the blood-brain barrier (BBB). The main functions of this barrier are maintenance of brain homeostasis, regulation of influx and efflux transport, and protection from harmful circulating endogenous and exogenous neurotoxins. These functions are determined by the BBB specialized multicellular structure. Every constituent cell type makes an indispensable contribution to the BBB integrity. Several reports indicated that the BBB is compromised in Alzheimer's disease (AD) which affects its integrity and functional activity. Furthermore, these changes in the BBB correlated well with dysfunction in the clearance of Aß across the BBB and formation of Aß plaques. Several hit compounds that were able to enhance the BBB integrity were identified from the high-throughput screening assay developed in our laboratory. Among these compounds etodolac, an NSAID drug, has shown to enhance the BBB model integrity measured by its ability to decrease the paracellular permeability markers Lucifer Yellow and inulin. Moreover, our data suggested that etodolac enhanced the active transport of amyloid-beta (Aß42) across the BBB model. In conclusion, the NSAID etodolac could be a promising drug for the treatment of Alzheimer's disease. In vivo studies are in progress to investigate etodolac effect in AD mouse model.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133663302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Richard, Ryan Jeansonne, J. Hebert, G. Stoute, Jacob M. King, Charles E. Taylor
Typical in vitro analysis of medical device performance occurs at room temperature (~70 degrees Fahrenheit). Effective evaluation requires at temperature studies for blood contacting medical devices for the following purposes: wear characteristics, thermal expansion, and temperature effects on sensors in the design. The task was to control the fluid within an ISO5198 hydraulic loop used to evaluate left ventricular assist devices at a given temperature between 95F and 105F. The design was to function within one degree Fahrenheit. This task was accomplished utilizing a microcontroller, the PowerSwitch Tail II, a DS18B20 waterproof temperature sensor, and an immersion heater. To manage heat loss from the piping section of the loop foam piping insulation was installed to all non-testing sections. The group was able to successfully thermally regulate temperature in the loop for a range of flow rates (2-10 LPM). The team utilized a pulsing control architecture to keep overshoot within the system to a minimum. The system takes approximately 6 mins to come to temperature with approximately a one degree overshoot. The longest recorded success of controlling the loop within a plus or minus one degree accuracy is approximately 2 hours. A computational model of the system was made using the thermofluid blocks of the Simulink Simscape foundation library. Approximated heat loss is roughly 70 W for the entire circuit, which equates to one degree Fahrenheit drop for every five minutes without heat input. The result of this design is a cost effective means of producing reflective in vivo thermal conditions.
{"title":"Thermal Management System for In Vitro Evalution of Circulatory Assist Devices at In Vivo Temperatures","authors":"J. Richard, Ryan Jeansonne, J. Hebert, G. Stoute, Jacob M. King, Charles E. Taylor","doi":"10.1109/SBEC.2016.85","DOIUrl":"https://doi.org/10.1109/SBEC.2016.85","url":null,"abstract":"Typical in vitro analysis of medical device performance occurs at room temperature (~70 degrees Fahrenheit). Effective evaluation requires at temperature studies for blood contacting medical devices for the following purposes: wear characteristics, thermal expansion, and temperature effects on sensors in the design. The task was to control the fluid within an ISO5198 hydraulic loop used to evaluate left ventricular assist devices at a given temperature between 95F and 105F. The design was to function within one degree Fahrenheit. This task was accomplished utilizing a microcontroller, the PowerSwitch Tail II, a DS18B20 waterproof temperature sensor, and an immersion heater. To manage heat loss from the piping section of the loop foam piping insulation was installed to all non-testing sections. The group was able to successfully thermally regulate temperature in the loop for a range of flow rates (2-10 LPM). The team utilized a pulsing control architecture to keep overshoot within the system to a minimum. The system takes approximately 6 mins to come to temperature with approximately a one degree overshoot. The longest recorded success of controlling the loop within a plus or minus one degree accuracy is approximately 2 hours. A computational model of the system was made using the thermofluid blocks of the Simulink Simscape foundation library. Approximated heat loss is roughly 70 W for the entire circuit, which equates to one degree Fahrenheit drop for every five minutes without heat input. The result of this design is a cost effective means of producing reflective in vivo thermal conditions.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114326757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previous experiments have documented the discovery of novel high-aspect ratio structures (HARS) composed of cystine and copper synthesized in a physiological environment. These HARS scale in size from nano to micro dimensions and have favorable properties such as biocompatibility, long-term stability, and non-agglomerating properties. Here we tested for: optimal synthesis conditions, stability limits, and their application to uniformly coat films. Because the HARS have an amino acid component, functionalization using layer-by-layer techniques may provide strategies for improved imaging, masking, and ordering the structures for controlled interaction with cells in 2d and 3d spaces.
{"title":"Synthesis and Post-Synthesis Optimization of Novel Copper Biocomposites and Exploration of Potential Applications","authors":"David L. Milam, S. Deodhar, M. DeCoster","doi":"10.1109/SBEC.2016.76","DOIUrl":"https://doi.org/10.1109/SBEC.2016.76","url":null,"abstract":"Previous experiments have documented the discovery of novel high-aspect ratio structures (HARS) composed of cystine and copper synthesized in a physiological environment. These HARS scale in size from nano to micro dimensions and have favorable properties such as biocompatibility, long-term stability, and non-agglomerating properties. Here we tested for: optimal synthesis conditions, stability limits, and their application to uniformly coat films. Because the HARS have an amino acid component, functionalization using layer-by-layer techniques may provide strategies for improved imaging, masking, and ordering the structures for controlled interaction with cells in 2d and 3d spaces.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124620975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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