Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-69-72
O. S. Olifirova, E. Bregadze, N. N. Trynov, A. A. Kozka, L. S. Krivoshlyk
The paper presents a clinical case of successful treatment for fourth-grade achalasia of cardia using video laparoscopic esophagocardiomyotomy with esophagocardiogastroplasty according to T.A. Suvorova. The surgery involves a peculiar process – the triangular-folded anterior wall of the stomach is sutured to the edges of the formed defect in the muscular layer of the esophagus and cardia. In the early and late postoperative period, patients did not have complications, dysphagia and regurgitation. In a year, contrast fluoroscopy of the esophagus and esophagoscopy revealed reduction in the esophagus length and width, free inflow of contrast into the stomach, absence of reflux esophagitis; the endoscope was freely moving throughout the esophagus.
{"title":"Video laparoscopic esophagocardiogastroplasty in cardiac achalasia","authors":"O. S. Olifirova, E. Bregadze, N. N. Trynov, A. A. Kozka, L. S. Krivoshlyk","doi":"10.34215/1609-1175-2023-2-69-72","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-69-72","url":null,"abstract":"The paper presents a clinical case of successful treatment for fourth-grade achalasia of cardia using video laparoscopic esophagocardiomyotomy with esophagocardiogastroplasty according to T.A. Suvorova. The surgery involves a peculiar process – the triangular-folded anterior wall of the stomach is sutured to the edges of the formed defect in the muscular layer of the esophagus and cardia. In the early and late postoperative period, patients did not have complications, dysphagia and regurgitation. In a year, contrast fluoroscopy of the esophagus and esophagoscopy revealed reduction in the esophagus length and width, free inflow of contrast into the stomach, absence of reflux esophagitis; the endoscope was freely moving throughout the esophagus.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90383070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-31-36
R. Kostiv, V. B. Shumatov, E. P. Kostiv, A. P. Prodan, S. L. Em, E. E. Kostivа, E. Kondratieva
Objective. To study the effectiveness of high tibial osteotomy (HTO) in the treatment for 2–3 stage osteoarthritis of the knee.Materials and methods. Over 2015–2022 period, 56 surgeries using HTO were performed in 49 patients with knee osteoarthritis of stages 2–3 at Vladivostok Clinical City Hospital No. 2. Biplanar osteotomy was performed above the tibial tuberosity. Locking compression plates were used for fixation. The results were assessed according to the Lysholm Knee Score and VAS.Results. The follow-up results in 37 patients were monitored up to 5 years. Deformity correction was revealed in each case. The study indicated a persistent reduction in the mean values of the VAS scale from 1.1 to 2.7, as well as a significant improvement in the clinical and functional characteristics of the knee joint according to the Lysholm Knee Score. In 5 years after the procedure, the survival rate comprised 100%.Conclusion. High tibial osteotomy is a complex procedure requiring long-term training and considerable experience of a surgeon, proper assessment of indications, meticulous preoperative planning, and adherence to surgical techniques. The HTO results demonstrate that a long-term delay in knee arthroplasty is feasible.
{"title":"High tibial osteotomy for 2–3 stage osteoarthritis as an alternative to knee arthroplasty","authors":"R. Kostiv, V. B. Shumatov, E. P. Kostiv, A. P. Prodan, S. L. Em, E. E. Kostivа, E. Kondratieva","doi":"10.34215/1609-1175-2023-2-31-36","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-31-36","url":null,"abstract":"Objective. To study the effectiveness of high tibial osteotomy (HTO) in the treatment for 2–3 stage osteoarthritis of the knee.Materials and methods. Over 2015–2022 period, 56 surgeries using HTO were performed in 49 patients with knee osteoarthritis of stages 2–3 at Vladivostok Clinical City Hospital No. 2. Biplanar osteotomy was performed above the tibial tuberosity. Locking compression plates were used for fixation. The results were assessed according to the Lysholm Knee Score and VAS.Results. The follow-up results in 37 patients were monitored up to 5 years. Deformity correction was revealed in each case. The study indicated a persistent reduction in the mean values of the VAS scale from 1.1 to 2.7, as well as a significant improvement in the clinical and functional characteristics of the knee joint according to the Lysholm Knee Score. In 5 years after the procedure, the survival rate comprised 100%.Conclusion. High tibial osteotomy is a complex procedure requiring long-term training and considerable experience of a surgeon, proper assessment of indications, meticulous preoperative planning, and adherence to surgical techniques. The HTO results demonstrate that a long-term delay in knee arthroplasty is feasible.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"281 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86578000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-73-76
P. V. Vasiliev, M. M. Skorobogatov, B. Z. Dzhafarova, N. G. Semkov, N. V. Klimovich
The paper presents a rare clinical case of a 36-year-old female patient with primary hyperparathyroidism (PHPT) and an ectopic parathyroid adenoma (EPA) in the mediastinum. Ectopic parathyroid adenoma in the mediastinum is found in 1–2% of cases. This is an extremely rare atypical localization as compared with many other possible uncommon locations. Thoracoscopic resection of the adenoma was performed. Pathohistological examination of the postoperative specimen confirmed the preliminary diagnosis. The specimen revealed typical parathyroid adenoma. On the seventh day after surgical treatment the patient was discharged in satisfactory condition.
{"title":"Surgical treatment of primary hyperparathyroidism with ectopic parathyroid adenoma in the mediastinum","authors":"P. V. Vasiliev, M. M. Skorobogatov, B. Z. Dzhafarova, N. G. Semkov, N. V. Klimovich","doi":"10.34215/1609-1175-2023-2-73-76","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-73-76","url":null,"abstract":"The paper presents a rare clinical case of a 36-year-old female patient with primary hyperparathyroidism (PHPT) and an ectopic parathyroid adenoma (EPA) in the mediastinum. Ectopic parathyroid adenoma in the mediastinum is found in 1–2% of cases. This is an extremely rare atypical localization as compared with many other possible uncommon locations. Thoracoscopic resection of the adenoma was performed. Pathohistological examination of the postoperative specimen confirmed the preliminary diagnosis. The specimen revealed typical parathyroid adenoma. On the seventh day after surgical treatment the patient was discharged in satisfactory condition.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75618608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-25-30
D. E. Vasiliev
The paper focuses on the assessment of factors affecting the health of medical personnel in forensic and pathology departments. Sanitary and hygienic working conditions in forensic medical institutions have specific features associated with microbial contamination, temperature and lighting conditions, air environment and other factors. Medical personnel was revealed to have high morbidity rate, caused by direct contacts with infected material. The paper summarizes current information on the disinfection, sanitary-hygienic and epidemic control measures as well as on the personnel infectious safety.
{"title":"Biological risk factors and methods to ensure the infectious safety of personnel in forensic and pathology departments","authors":"D. E. Vasiliev","doi":"10.34215/1609-1175-2023-2-25-30","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-25-30","url":null,"abstract":"The paper focuses on the assessment of factors affecting the health of medical personnel in forensic and pathology departments. Sanitary and hygienic working conditions in forensic medical institutions have specific features associated with microbial contamination, temperature and lighting conditions, air environment and other factors. Medical personnel was revealed to have high morbidity rate, caused by direct contacts with infected material. The paper summarizes current information on the disinfection, sanitary-hygienic and epidemic control measures as well as on the personnel infectious safety.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75012656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-20-24
V. M. Koldaev, A. Kropotov, O. Li
Betalains are plant pigments synthesized in the cells of Caryophyllales (red beets, opuntia, etc.). They are involved in the inactivation of reactive oxygen species and free radicals. The paper summarizes the data on the physical-chemical and pharmacological properties of betalains. Betalains eliminate the consequences of oxidative stress, effectively correct metabolic disorders in diabetes mellitus and abdominal obesity, and reduce the risk of cardiovascular diseases. A betalain-enriched diet has a wide range of anticancer effects. Betalains protect brain dopaminergic neurons from oxidative damage and reduce the severity of neurodegenerative disorders in Alzheimer’s and Parkinson’s disease. However, betalains are not stable enough to resist degradation during processing and storage of plant raw materials. Therefore, developing non-damaging technologies for betalain-containing treatment is highly relevant.
{"title":"Betalains in practical medicine","authors":"V. M. Koldaev, A. Kropotov, O. Li","doi":"10.34215/1609-1175-2023-2-20-24","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-20-24","url":null,"abstract":"Betalains are plant pigments synthesized in the cells of Caryophyllales (red beets, opuntia, etc.). They are involved in the inactivation of reactive oxygen species and free radicals. The paper summarizes the data on the physical-chemical and pharmacological properties of betalains. Betalains eliminate the consequences of oxidative stress, effectively correct metabolic disorders in diabetes mellitus and abdominal obesity, and reduce the risk of cardiovascular diseases. A betalain-enriched diet has a wide range of anticancer effects. Betalains protect brain dopaminergic neurons from oxidative damage and reduce the severity of neurodegenerative disorders in Alzheimer’s and Parkinson’s disease. However, betalains are not stable enough to resist degradation during processing and storage of plant raw materials. Therefore, developing non-damaging technologies for betalain-containing treatment is highly relevant.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72864640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-65-68
A. N. Zhekotov, V. N. Kotelnikov, B. Geltser, A. Popov
Aim. To investigate specific features of regional blood flow in the liver of young people with vitamin B12 deficiency anemia (VBDA).Materials and methods. A total of 64 patients diagnosed with VBDA with the median age of 38 years and 95% confidence interval [26; 49] were examined. Hemodynamic parameters of the liver and central circulation were assessed using pulsedwave Doppler ultrasound with color and power imaging. Statistical data was processed by Statistica 25.0.Results. At the onset of VBDA, the revealed hemodynamic disorders are primarily associated with a 13.8% decrease in the ratio of the linear velocity of the portal flow and the diameter of the portal vein, which leads to liver blood stagnation. A long medical history of VBDA is associated with the venous collector of hepatic hemodynamics and a decrease in the volume values (16.8%) against the background of increased peripheral vascular tone of hepatic vessels (23.5%). A correlation between the indicators of regional blood flow in the liver and the type of central hemodynamics was revealed, being most pronounced in severe VBDA and the hypokinetic hemodynamics type.Conclusion. Assessment of the regional blood flow of the liver was found to be an effective method for diagnosing the state of target organs in VBDA and for verifying the predictors of VBDA severity.
{"title":"Features of regional blood flow in young people with vitamin B12 deficiency anemia","authors":"A. N. Zhekotov, V. N. Kotelnikov, B. Geltser, A. Popov","doi":"10.34215/1609-1175-2023-2-65-68","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-65-68","url":null,"abstract":"Aim. To investigate specific features of regional blood flow in the liver of young people with vitamin B12 deficiency anemia (VBDA).Materials and methods. A total of 64 patients diagnosed with VBDA with the median age of 38 years and 95% confidence interval [26; 49] were examined. Hemodynamic parameters of the liver and central circulation were assessed using pulsedwave Doppler ultrasound with color and power imaging. Statistical data was processed by Statistica 25.0.Results. At the onset of VBDA, the revealed hemodynamic disorders are primarily associated with a 13.8% decrease in the ratio of the linear velocity of the portal flow and the diameter of the portal vein, which leads to liver blood stagnation. A long medical history of VBDA is associated with the venous collector of hepatic hemodynamics and a decrease in the volume values (16.8%) against the background of increased peripheral vascular tone of hepatic vessels (23.5%). A correlation between the indicators of regional blood flow in the liver and the type of central hemodynamics was revealed, being most pronounced in severe VBDA and the hypokinetic hemodynamics type.Conclusion. Assessment of the regional blood flow of the liver was found to be an effective method for diagnosing the state of target organs in VBDA and for verifying the predictors of VBDA severity.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73926277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-54-59
V. Ivanis, A. Popov
Objective. To assess factors in COVID-19-associated lethal outcomes and to identify gaps in the quality of inpatient medical care.Materials and methods. An analysis of expert opinions (reports of medical care quality) was carried out using a random sample of 116 medical histories of COVID-19-associated lethal outcomes from various hospitals in Primorsky Krai for the period from June 2020 to August 2021.Results. The highest mortality was observed among patients aged 60–79 (53.4%) and 80–96 (30.2%). The lethal outcome occurred, on average, on the 12.8 ± 1.3 day of illness. Concomitant chronic pathologies of various organs and systems was observed in 96.5% of the deceased, with the majority of such patients having had comorbidities of three or more body systems (55.2%). Discrepancies in clinical and pathoanatomic diagnoses were noted in nine cases (7.8%) and were related to the structure of the clinical diagnosis and the reassessment of COVID-19 complications. The immediate cause of death in 84.5% of patients was acute respiratory distress syndrome.Conclusion. Elderly and senile patients with comorbid diseases are at highest risk of severe and lethal COVID-19 outcome. The difficulty of managing such patients is associated with the complexity of diagnosis, interpretation of critical conditions, and selection of appropriate therapy.
{"title":"An analysis of COVID-19-associated deaths in Primorsky Krai","authors":"V. Ivanis, A. Popov","doi":"10.34215/1609-1175-2023-2-54-59","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-54-59","url":null,"abstract":"Objective. To assess factors in COVID-19-associated lethal outcomes and to identify gaps in the quality of inpatient medical care.Materials and methods. An analysis of expert opinions (reports of medical care quality) was carried out using a random sample of 116 medical histories of COVID-19-associated lethal outcomes from various hospitals in Primorsky Krai for the period from June 2020 to August 2021.Results. The highest mortality was observed among patients aged 60–79 (53.4%) and 80–96 (30.2%). The lethal outcome occurred, on average, on the 12.8 ± 1.3 day of illness. Concomitant chronic pathologies of various organs and systems was observed in 96.5% of the deceased, with the majority of such patients having had comorbidities of three or more body systems (55.2%). Discrepancies in clinical and pathoanatomic diagnoses were noted in nine cases (7.8%) and were related to the structure of the clinical diagnosis and the reassessment of COVID-19 complications. The immediate cause of death in 84.5% of patients was acute respiratory distress syndrome.Conclusion. Elderly and senile patients with comorbid diseases are at highest risk of severe and lethal COVID-19 outcome. The difficulty of managing such patients is associated with the complexity of diagnosis, interpretation of critical conditions, and selection of appropriate therapy.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79444165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.34215/1609-1175-2023-2-5-8
A. Antonov, V. Volovik, S. N. Berezuckii, E. P. Kostiv
The paper proposes and substantiates an arthroscopic classification of pathological processes in the hip joint associated with avascular necrosis of the femoral head (ANFH). In 2018–2022, the authors developed and advanced to the clinic “Method of minimally invasive two-stage decompression with bone alloplasty” (RF patent No. 2691543), which involved diagnostic and therapeutic arthroscopy of the hip joint as its first stage. The international ARCO classification (Association Research Circulation Osseous classification) was chosen as the prototype for the invention. The endoscopic view was recorded and compared with the data of radiological research methods (radiography, spiral CT and MRI). The revealed changes are characterized by the absence of pronounced pathological signs at stages 0, I according to ARCO, which testifies to the possibility of arthroscopic intervention only for the purpose of joint cavity drainage. Further development of necrosis is accompanied by the formation of cartilage flaps, cartilage defects, acetabular labrum tears, lysis of the ligament of the femoral head with the subsequent development of arthrosis, and, therefore, requires a combined approach.
{"title":"Arthroscopic classification in comprehensive diagnosis of avascular necrosis of femoral head","authors":"A. Antonov, V. Volovik, S. N. Berezuckii, E. P. Kostiv","doi":"10.34215/1609-1175-2023-2-5-8","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-5-8","url":null,"abstract":"The paper proposes and substantiates an arthroscopic classification of pathological processes in the hip joint associated with avascular necrosis of the femoral head (ANFH). In 2018–2022, the authors developed and advanced to the clinic “Method of minimally invasive two-stage decompression with bone alloplasty” (RF patent No. 2691543), which involved diagnostic and therapeutic arthroscopy of the hip joint as its first stage. The international ARCO classification (Association Research Circulation Osseous classification) was chosen as the prototype for the invention. The endoscopic view was recorded and compared with the data of radiological research methods (radiography, spiral CT and MRI). The revealed changes are characterized by the absence of pronounced pathological signs at stages 0, I according to ARCO, which testifies to the possibility of arthroscopic intervention only for the purpose of joint cavity drainage. Further development of necrosis is accompanied by the formation of cartilage flaps, cartilage defects, acetabular labrum tears, lysis of the ligament of the femoral head with the subsequent development of arthrosis, and, therefore, requires a combined approach.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91551803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.34215/1609-1175-2023-2-9-14
E. Skryabin, D. Romanenko, Yu. V. Evstropova, A. Nazarova
Pain in patients with transitional lumbosacral vertebrae is managed with surgical and non-surgical treatment. The non-surgical treatment involves techniques of traditional oriental medicine, manual therapy, physiotherapeutic procedures, and pharmacological blockade. Surgical interventions include resection of the pseudarthrosis, minimally invasive endoscopic surgery, radiofrequency ablation, and interbody fusion. The paper presents immediate and, in some cases, long-term outcomes, the causes of unsatisfactory outcomes and complications. The relevance of the study stems from the high prevalence of lumbosacral transitional vertebrae in the population, and, moreover, the lack of unified, generally accepted algorithms in choosing individual treatment, based on the history of patients, their age, as well as concomitant dystrophic changes of the superior spinal motion segments.
{"title":"Review of current pain management in patients with lumbosacral transitional vertebrae","authors":"E. Skryabin, D. Romanenko, Yu. V. Evstropova, A. Nazarova","doi":"10.34215/1609-1175-2023-2-9-14","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-9-14","url":null,"abstract":"Pain in patients with transitional lumbosacral vertebrae is managed with surgical and non-surgical treatment. The non-surgical treatment involves techniques of traditional oriental medicine, manual therapy, physiotherapeutic procedures, and pharmacological blockade. Surgical interventions include resection of the pseudarthrosis, minimally invasive endoscopic surgery, radiofrequency ablation, and interbody fusion. The paper presents immediate and, in some cases, long-term outcomes, the causes of unsatisfactory outcomes and complications. The relevance of the study stems from the high prevalence of lumbosacral transitional vertebrae in the population, and, moreover, the lack of unified, generally accepted algorithms in choosing individual treatment, based on the history of patients, their age, as well as concomitant dystrophic changes of the superior spinal motion segments.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72753603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-14DOI: 10.34215/1609-1175-2023-1-75-80
T. S. Komenkova, E. Zaitseva
Aim. To conduct comprehensive evaluation of microbiological properties of Enterococcus faecalis, isolated from urine in children with urinary system infections (UTI), to determine their etiological significance.Materials and methods. The study employed clinical isolates E. faecalis (n = 51) from the urine of children aged 3 days to 17 years who were treated for urinary tract infection between 2013 and 2017. The biological properties of enterococci were evaluated by means of classical microbiological and up-to-date molecular genetic methods. Statistical processing of digital data was carried out using non-parametric methods.Results. Phenotypic and genetic heterogeneity of microbiological properties of the studied urinary enterococci isolates was revealed. Using statistical methods of analysis, the authors established significant correlations between pathogenicity genes, antibiotic resistance and phenotypic manifestations of biological properties in urinary isolates E. faecalis. The results of evaluating the phenotypic manifestations of biological properties and the presence of certain genes enabled the enterococci to be classified into groups that correlated with certain sequence types (ST). Based on the revealed relationships of some biological properties of urinary isolates E. faecalis with certain sequence types, the authors developed an algorithm for assessing etiologically significant and highly virulent E. faecalis isolated from the urine of children with UTI.Conclusions. A comprehensive determination of some, potentially relevant biological properties, of the pathogen – enzymatic activity associated with pathogenicity and biochemical activities, antibiotic resistance (not only at the phenotypic, but also at the genetic level) – allows for assessing the diagnostic value of urostams E. faecalis, isolated from the urine of children with UTI, which will contribute to a personalized approach to treatment of these patients.
{"title":"Evaluating etiological significance of Enterococcus faecalis isolated from children with urinary tract infection","authors":"T. S. Komenkova, E. Zaitseva","doi":"10.34215/1609-1175-2023-1-75-80","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-1-75-80","url":null,"abstract":"Aim. To conduct comprehensive evaluation of microbiological properties of Enterococcus faecalis, isolated from urine in children with urinary system infections (UTI), to determine their etiological significance.Materials and methods. The study employed clinical isolates E. faecalis (n = 51) from the urine of children aged 3 days to 17 years who were treated for urinary tract infection between 2013 and 2017. The biological properties of enterococci were evaluated by means of classical microbiological and up-to-date molecular genetic methods. Statistical processing of digital data was carried out using non-parametric methods.Results. Phenotypic and genetic heterogeneity of microbiological properties of the studied urinary enterococci isolates was revealed. Using statistical methods of analysis, the authors established significant correlations between pathogenicity genes, antibiotic resistance and phenotypic manifestations of biological properties in urinary isolates E. faecalis. The results of evaluating the phenotypic manifestations of biological properties and the presence of certain genes enabled the enterococci to be classified into groups that correlated with certain sequence types (ST). Based on the revealed relationships of some biological properties of urinary isolates E. faecalis with certain sequence types, the authors developed an algorithm for assessing etiologically significant and highly virulent E. faecalis isolated from the urine of children with UTI.Conclusions. A comprehensive determination of some, potentially relevant biological properties, of the pathogen – enzymatic activity associated with pathogenicity and biochemical activities, antibiotic resistance (not only at the phenotypic, but also at the genetic level) – allows for assessing the diagnostic value of urostams E. faecalis, isolated from the urine of children with UTI, which will contribute to a personalized approach to treatment of these patients.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77733382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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