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TO STUDY THE ETIOLOGICAL PROFILE OF SHORT STATURE AMONG CHILDREN ATTENDING TERTIARY CARE CENTRE 研究三级护理中心儿童身材矮小的病因概况
Pub Date : 2024-01-15 DOI: 10.36106/paripex/0603590
Thilagavathi Duraisamy, Gem Raghav Prashanth R, Karnam Ravikumar
Background Early detection and diagnosis of short stature decrease the effect of any underlying health condition andoptimizes final adult height.This study was done identify the etiological profile of short stature.Methodology This was aprospective observational study conducted in children aged 2 to 18 years with short stature. Children who fail tocomplete the etiological work up and those who are not fitting in definition for short stature were excluded. Results 80children were included .44 were females and 36 were males. Endocrinological cause was the commonest, 53%(N=42)among which Growth hormone deficiency was predominant (20%).24 children(30%) had non endocrine causes amongwhich syndromic causes were predominant(N=9).14 children had non pathological causes and familial shortstature(N=8) was predominant in them Conclusion Pathological short stature was predominat among which endocrinecauses were the commonest. Isolated Growth Hormone deficiency was the most common endocrine cause followed byhypopituitarism and hypothyroidism. There was statistically significant relationship between the presence ofdysmorphism (p< .01) and parental consanguinity (p < .05) separately with the etiology. Majority (40%)were agedbetween 11-18 years denoting fairly late referral for short stature . So general paediatricians could be made aware ofroutine growth monitoring in children & early referral to a tertiary centre.
研究方法 这是一项前瞻性观察研究,研究对象为 2 至 18 岁身材矮小的儿童。未完成病因学检查的儿童和不符合矮身材定义的儿童被排除在外。结果 共纳入 80 名儿童,其中女性 44 名,男性 36 名。内分泌原因最常见,占 53%(42 例),其中以生长激素缺乏为主(20%);24 例儿童(30%)为非内分泌原因,其中以综合征原因为主(9 例);14 例儿童为非病理原因,其中以家族性身材矮小为主(8 例)。孤立的生长激素缺乏症是最常见的内分泌原因,其次是垂体功能减退症和甲状腺功能减退症。在统计学上,畸形(p< .01)和父母血缘关系(p< .05)分别与病因有明显的关系。大多数患者(40%)的年龄在 11-18 岁之间,这说明身材矮小的转诊时间较晚。因此,普通儿科医生应注意对儿童进行常规生长监测,并及早转诊至三级中心。
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引用次数: 0
THE RANK AND RANKL NEXUS – MOLECULAR ASPECTS 等级与等级关系--分子方面
Pub Date : 2024-01-15 DOI: 10.36106/paripex/3703970
Javeria Khan, Devaratnamma Mv, Asma Naaz, Pooja Deshkar, Sahiti Soni, Sumanya Bandi
RANKL are the chemical mediators secreted by the resident cells of the connective tissue and in the mileau of periodontiumthey are released during the process of bone turnover either for bone remodelling during orthodontic tooth movement,normal masticatory force bearing, age related changes or for bone resorption due to pathological reasons where plaqueinfluences the cells of inflammation to release PGE2, IL-1 and TNF alpha. These RANKL act on the circulating pre osteoclastsor monocyte macrophage cells which under the influence of M-CSF will start to colacase to form multinucleated osteoclaststhat will resorb the bone. Thus, for these various changes to occur in the macrophages and preosteoclasts there will be aneed of transcription factors like NFK฀, NFATc1, cFos and others. To understand intracellular mechanisms when RANKLbinds onto the trimeric receptor RANK which leads to a better understanding of therapeutic management to deal withpathological bone destructive disease, so we have consolidated this narrative review.
RANKL 是由结缔组织的常驻细胞分泌的化学介质,在牙周膜中,它们在骨转换过程中释放,或是在正畸牙齿移动、正常咀嚼受力、年龄相关变化时用于骨重塑,或是由于病理原因引起的骨吸收,即牙菌斑影响炎症细胞释放 PGE2、IL-1 和 TNF alpha。这些 RANKL 会作用于循环中的前破骨细胞或单核巨噬细胞,在 M-CSF 的影响下,这些细胞会开始钙化,形成多核破骨细胞,从而吸收骨质。因此,巨噬细胞和前破骨细胞要发生这些变化,就需要 NFK↪CN_E00↩、NFATc1、cFos 等转录因子的参与。为了了解当 RANKL 结合到三聚受体 RANK 上时的细胞内机制,从而更好地了解治疗方法,以应对病理性骨破坏性疾病,我们整理了这篇叙述性综述。
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引用次数: 0
A UNIQUE CASE OF MAXILLARY RHINOSPORIDIOSIS 一例独特的上颌骨鼻孢子虫病
Pub Date : 2024-01-15 DOI: 10.36106/paripex/1400945
Digvijay Singh
Rhinosporidiosis is a chronic granulomatous disease of nasal cavity. It is prevalent in few parts of India. Here we present acase which involved the maxillary sinus with its extension to choana and nasopharynx. Mass removed by lateralrhinotomy approach. Very few articles published on involvement of maxilla and different surgical approaches werementioned for its removal.
鼻孢子虫病是一种鼻腔慢性肉芽肿性疾病。该病在印度少数地区流行。我们在此介绍一例累及上颌窦并扩展至咽喉和鼻咽的病例。通过鼻外侧切开术切除了肿块。关于上颌窦受累的文章很少,也很少提到用不同的手术方法切除肿块。
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引用次数: 0
RELEVANCE OF INTERNATIONAL SOLAR ALLIANCE (ISA) AND ITS CHALLANGES 国际太阳能联盟(ISA)的现实意义及其挑战
Pub Date : 2024-01-15 DOI: 10.36106/paripex/5202875
Md. Asaad Raza
In the development of cost-effective and transformational solar energy solutions,International Solar Alliance (ISA) is theaction-oriented and mobilized efforts among various countries.ISA is a member-driven and collaborative platform andthere are more than 120 countries working under ISA Framework Agreement.India is one of the leading country and hasbeen reelected for ISA. The activity of the ISA is based on the four priory such as Analytics & Advocacy, CapacityBuilding, Programmatic Support and Readiness & enabling activities.The governance structure of the ISA is followed byISA Assembly as an apex decision-making body, Steering Committee for strategic guidance, Secretariat asadministrative arm and Head of ISA headed by the Director General.Due to immense demand to create and implementsolar energy, ISA is initiated with One Sun, One World, One Grid (OSOWOG) programme. Now a days, ISA has variouschallenges like funding, policy coordination, limited participation and implementation. In this regards India haslaunched the scheme named as Indian Technical and Economic Cooperation (ITEC). For its proper implementation toget fruitful results on the ground,the administration will play vital role.
在开发具有成本效益和变革性的太阳能解决方案方面,国际太阳能联盟(ISA)是一个以行动为导向、动员各国共同努力的平台。国际太阳能协会的活动以四个优先领域为基础,如分析与宣传、能力建设、计划支持以及准备与扶持活动。国际太阳能协会的治理结构包括:作为最高决策机构的国际太阳能协会大会、负责战略指导的指导委员会、作为行政机构的秘书处以及由总干事领导的国际太阳能协会负责人。由于创造和实施太阳能的巨大需求,国际太阳能协会启动了 "一个太阳、一个世界、一个电网"(OSOWOG)计划。如今,国际太阳能署面临着资金、政策协调、有限参与和实施等各种挑战。为此,印度推出了名为 "印度技术与经济合作"(ITEC)的计划。为使该计划在当地得到妥善实施并取得丰硕成果,行政部门将发挥至关重要的作用。
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引用次数: 0
EFFECTS OF THREE DIFFERENT TRAINING PROGRAMMES ON ABDOMINAL ADIPOSITY OF OVERWEIGHT COLLEGE GIRLS 三种不同训练计划对超重女大学生腹部脂肪含量的影响
Pub Date : 2024-01-15 DOI: 10.36106/paripex/0902606
D. Biswas
The World Health Organization (WHO) describes overweight as one of the today's most important public healthproblems, which is escalating as a global epidemic. The purpose of the present study was an endeavor to the bestmethod of handling overweight.Out of 96 selected participants from fluvio coastal zone of west Bengal,India on the basisof BMI,80 overweight girls (average age:20) were consider for the study.The subjects were divided into four groups (20for each group) randomly namely Weight Training Group (WTG), Aerobic Training Group (ATG), Graded CircuitTraining Group (GCTG) and Control Group (CG).Separately designed 12 weeks training programme for WTG,ATG andGCTG was applied on the subjects at morning between 8.00 am to 9.15am for three alternative days per week. Afterevery four weeks,total load was increased.Pre and post test on the groups were conducted to measure the training effecton Abdominal Adiposity of the subjects. The collected data were statistically analyzed by using the analysis of Covariance (p<0.05) to determine differences, the LSD test was applied as a post hoc test to find out the paired meandifferences. From the obtaining result, it was concluded that weight training, aerobics and graded circuit training arefound to be effective for reducing Abdominal Adiposity of overweight college girls.
世界卫生组织(WHO)将超重描述为当今最重要的公共卫生问题之一,它正日益成为一种全球性流行病。从印度西孟加拉邦弗卢维奥沿海地区根据体重指数选出的 96 名参与者中,有 80 名超重女孩(平均年龄:20 岁)被纳入研究。受试者被随机分为四组(每组 20 人),即体重训练组(WTG)、有氧训练组(ATG)、分级循环训练组(GCTG)和对照组(CG)。对各组进行了前后测试,以测量训练对受试者腹部脂肪的影响。收集的数据采用协方差分析法(P<0.05)进行统计分析,以确定差异,并采用 LSD 检验作为事后检验,以找出配对差异。结果表明,重量训练、有氧运动和分级循环训练对减少超重女大学生的腹部脂肪含量有效。
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引用次数: 0
THE IMPACT OF BUSINESS INTELLIGENCE AND COMPETITIVE INTELLIGENCE IN MANAGEMENT: A BIBLIOMETRIC ANALYSIS 商业情报和竞争情报对管理的影响:文献计量分析
Pub Date : 2024-01-15 DOI: 10.36106/paripex/2403035
Nicolae Alexandru Budeanu
The research in management field from the last decades showed that both knowledge and intelligence are considered assome of the most important assets which help business organizations achieve the competitive advantage in a certainmarket. In our current times, determined by uncertainty and ambiguity, leaders and managers are in a constant need ofvaluable and timely information that is required for taking the most desirable decision for the company. Given so,researchers and practitioners developed certain tools and activities in order to achieve the information necessary todecision making process, from both inside and outside the company, known as business intelligence and competitiveintelligence. Therefore, this article contains a literature review about the connections between business intelligence,competitive intelligence, on one hand, and management, on the other hand. Using the specialized software VOSviewer,this research presents the bibliometric analysis based on the co-occurrences of certain keywords, which demonstratesthe inter-correlation of some specific research fields. The data examined using VOSviewer was retrieved from Web ofScience core collection, the world`s largest bibliographic database for scientific research.
过去几十年在管理领域的研究表明,知识和智力被认为是帮助企业组织在特定市场中取得竞争优势的最重要资产之一。在当今这个充满不确定性和模糊性的时代,领导者和管理者不断需要有价值的、及时的信息,以便为公司做出最理想的决策。有鉴于此,研究人员和从业人员开发了一些工具和活动,以便从公司内部和外部获得决策过程所需的信息,这些工具和活动被称为商业情报和竞争情报。因此,本文对商业智能、竞争情报与管理之间的联系进行了文献综述。本研究使用专业软件 VOSviewer,根据某些关键词的共同出现情况进行了文献计量分析,从而证明了某些特定研究领域的相互关联性。使用 VOSviewer 检查的数据取自世界上最大的科学研究文献数据库 Web of Science 核心集。
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引用次数: 0
"FROM TREATMENT TO CHALLENGE: EXPLORING STEROID-INDUCED DIABETES MELLITUS – A COMPREHENSIVE CASE STUDY." "从治疗到挑战:探索类固醇诱发的糖尿病--综合案例研究"。
Pub Date : 2024-01-15 DOI: 10.36106/paripex/2303309
Krishna Upadhye, Uttam Kumar Aggarwal
Steroid-induced diabetes mellitus (SIDM) represents a significant clinical challenge, arising as a consequence ofglucocorticoid therapy commonly used in various medical conditions. Clinicians who want to reduce inflammationcaused by immune system reactions commonly prescribe steroids. However, one significant side effect of steroidtreatment is that patients' blood sugar levels rise. Long-term steroid use raises the risk of acquiring diabetes mellitus.Despite the widespread use of steroids for their anti-inflammatory and immunosuppressive properties,SIDM remains acommon and potentially harmful complication that necessitates careful consideration in clinical practice. Two of themost often given steroids, cortisone and prednisone, increase the liver's ability to produce glucose and reduce cells'sensitivity to Insulin. This case study underscores the need for early detection and effective management of SIDM,emphasizing the importance of individualized treatment strategies.Furthermore,it highlights the gaps in understandingthe impact of hyperglycemia associated with steroid use on clinical morbidity and mortality,urging for comprehensiveguidelines to prevent complications and optimize patient outcomes in the context of the hyperglycemic state. Thesubject of this case study is a 53-year-old woman who was prescribed injections of methylprednisolone after beingdiagnosed with nephrotic syndrome. Her blood sugar levels noticeably increased after taking this medicine, which isconsistent with the classic presentation of steroid-induced diabetes mellitus. This case study explores the complexrelationship between steroids and diabetes mellitus, elucidating the mechanisms underlying hyperglycemia inducedby glucocorticoids.
类固醇诱发的糖尿病(SIDM)是一项重大的临床挑战,它是糖皮质激素治疗的结果,常用于各种疾病。临床医生希望减轻免疫系统反应引起的炎症,通常会处方类固醇。然而,类固醇治疗的一个明显副作用是患者的血糖水平会升高。尽管类固醇具有抗炎和免疫抑制的作用,因此被广泛使用,但 SIDM 仍是一种常见且可能有害的并发症,临床实践中必须慎重考虑。可的松和泼尼松是最常用的两种类固醇,它们会增加肝脏产生葡萄糖的能力,降低细胞对胰岛素的敏感性。本病例研究强调了早期发现和有效管理 SIDM 的必要性,强调了个体化治疗策略的重要性。此外,本病例研究还强调了在了解与类固醇使用相关的高血糖对临床发病率和死亡率的影响方面存在的差距,敦促制定综合指南,以预防并发症并优化高血糖状态下的患者预后。本病例的研究对象是一名 53 岁的女性,在被诊断为肾病综合征后,她被处方注射甲基强的松龙。服药后,她的血糖水平明显升高,这符合类固醇诱发糖尿病的典型表现。本病例研究探讨了类固醇与糖尿病之间的复杂关系,阐明了糖皮质激素诱发高血糖的机制。
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引用次数: 0
RESILIENCE IN THE PRIMARY CAREGIVERS OF PATIENTS WITH SCHIZOPHRENIA, BIPOLAR AFFECTIVE DISORDER AND ALCOHOL DEPENDENCE SYNDROME 精神分裂症、双相情感障碍和酒精依赖综合征患者主要照顾者的复原力
Pub Date : 2024-01-15 DOI: 10.36106/paripex/3400223
Pranavi Reddy Gunamgari, Rajendhar Soorineedu, Raja shekar Reballi, Sivaprasad Kasimahanti
Caregivers who possess resilience are better able to manage and overcome adversity that comes with caring for a familymember diagnosed with major mental illnesses like Schizophrenia,Bipolar Affective Disorder and Alcohol DependenceSyndrome.Family plays a key role in the care of patients with mental illnesses especially in India owing to the tradition ofinterdependence and the lack of sufficient mental health facilities making it important to understand the resilience of thecaregiver in caring for the mentally ill. Aim:The aim of the present study is to study the resilience in primary caregiversof patients with Schizophrenia, Bipolar Affective Disorder and Alcohol dependence syndrome. Methods: The crosssectional comparative study included 90 primary caregivers of patients, 30 from each group. The diagnoses of thepatients were confirmed with the MINI screen scale.A semi-structured interview was used to obtain demographic dataand resilience in the caregivers was measured using the Connor Davidson Resilience Scale. Results: Resilience wasfound to be higher in males, mostly children of the patients hailing from higher income groups and carers with sharedburden. Caregivers of the patients with schizophrenia were found to have higher resilience than those of the other 2groups. Conclusion: Gender, age, socioeconomic status, family support and diagnosis were all factors found to beinfluencing resilience in a caregiver.
家庭在照顾精神疾病患者的过程中扮演着关键的角色,尤其是在印度,由于传统上的相互依赖以及缺乏足够的精神健康设施,因此了解照顾者在照顾精神疾病患者过程中的抗逆力就显得尤为重要。目的:本研究旨在了解精神分裂症、双相情感障碍和酒精依赖综合症患者的主要护理者的适应能力。研究方法这项横断面比较研究包括 90 名患者的主要照顾者,每组 30 人。采用半结构式访谈获取人口统计学数据,并使用康纳-戴维森复原力量表测量照顾者的复原力。结果显示结果发现,男性的抗逆力较高,主要是来自高收入群体的患者子女和分担负担的照护者。精神分裂症患者照护者的复原力高于其他两组照护者。结论性别、年龄、社会经济地位、家庭支持和诊断都是影响照顾者复原力的因素。
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引用次数: 0
EFFICACY OF VIDEO-ASSISTED THORACOSCOPIC SURGERY (VATS) IN CHILDREN WITH EARLY EMPYEMA THORACIS IN COMPARISON TO OPEN THORACOTOMY 视频辅助胸腔镜手术(Vats)对早期胸腔积液儿童的疗效与开胸手术的比较
Pub Date : 2024-01-15 DOI: 10.36106/paripex/2500754
C. B. Rao, M. Rajesh, D. Swetha, G. M. Irfan, P. S. Reddy
Background/Purpose: VATS is more effective in early empyema which includes exudative and earlyfibrinopurulent phase.This study evaluates the role of VATS and compares the results with open decorticationcases done during the same period for early empyema thoracis. Method: A prospective study was done onchildren with empyema thoracis who underwent VATS from March 2017 to March 2020 in a single large center. Thecollected data included age, clinical presentation, radiological investigation, pleural fluid analysis, intraoperativefindings,histopathological findings and post operative course.The length of stay and the post-operative time taken forclinical and radiological lung expansion was compared with cases of open decortication done for early empyemaduring the same period of study Results: Of the198 cases of empyema, 54 cases underwent VATS and opendecortication was done in 130 children.Postoperatively patients became afebrile in 2 ± 1.2 days in VATS and 7 ± 3.2 daysin open decortication.Clinical and radiological expansion was earlier in VATS with 3 ± 2.1 and 6 ± 2.2 days respectively.Conclusions: The prospective study concludes that VATS is more effective and less invasive than open thoracotomy forearly empyema thoracis in decreasing the morbidity and has better cosmesis.
背景/目的:VATS 对早期肺水肿(包括渗出期和早期纤维蛋白化脓期)更有效。本研究评估了 VATS 的作用,并将其结果与同期针对早期胸腔积液进行的开胸去栓术进行了比较。方法:一项前瞻性研究针对2017年3月至2020年3月在一家大型中心接受VATS手术的胸腔积液患儿。收集的数据包括年龄、临床表现、放射学检查、胸腔积液分析、术中发现、组织病理学结果和术后病程。将住院时间、术后临床和放射学肺扩张所需的时间与同期为早期肺水肿进行开胸去痰术的病例进行比较 结果:在198例肺水肿病例中,有54例接受了VATS手术,130名儿童接受了开胸手术。术后患者转为无热的时间,VATS手术为2±1.2天,开胸手术为7±3.2天:这项前瞻性研究得出结论,与开胸切除术相比,VATS术在降低早期胸腔积液的发病率方面更有效、创伤更小,而且术后效果更好。
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引用次数: 0
COMPARISON OF ULTRASOUND GUIDED FEMORAL NERVE BLOCK AND SYSTEMIC INTRAVENOUS ANALGESIA FOR PAIN RELIEF IN TRAUMATIC SHAFT FEMUR FRACTURES 比较超声引导下股神经阻滞和全身静脉镇痛在股骨创伤性骨折中的镇痛效果
Pub Date : 2024-01-15 DOI: 10.36106/paripex/8900413
Akanksha Monil Parsana, Ajay Kumar Verma, Roshni Gupta
Background: Aims and USG guided femoral nerve block is useful technique for pain relief in fracture shaft femur.Objective: 1) To study whether USG guided femoral nerve block is more effective in pain management of femoral shaftfractures than systemic intravenous analgesia. 2) To study the duration of action of femoral nerve block for pain relief infemoral shaft fractures. 100 patients of ASA I and II, aged 20-50 years, with traumatic fracture Materials and Methods:femur were randomly allocated to group FNB (n-50, USG guided femoral nerve block using 10 ml 0.75% Ropicvacaine)and group DICLO (n-50, systemic analgesia using Inj. Diclofenac 75 mg.) Each case was subsequently followed up foronset and total duration of analgesia till 6 hours postoperatively. Efficacy in both groups was assessed by visual analoguescale. There is no significant difference in onset of action between both the groups. The duration Results and Summary:of action in group FNB was more (5.58±1.08 hrs) than group DICLO (3.40±1.20 hrs). Visual analogue score showedsignificant pain reduction in group FNB after 15 minutes and also at 6hr(p=0.001) in comparison with group DICLO.Conclusion: Femoral nerve block is safe, simple and more efficacious procedure in comparison to systemic IVanalgesia for acute pain management in patients with fracture shaft femur.
背景目的:1)研究 USG 引导下的股神经阻滞在股骨干骨折的疼痛治疗中是否比全身静脉镇痛更有效。2)研究股神经阻滞缓解股骨干骨折疼痛的作用时间。材料和方法:将 100 名 ASA I 级和 II 级、年龄在 20-50 岁之间的创伤性骨折患者随机分配到 FNB 组(n-50,USG 引导下的股神经阻滞,使用 10 毫升 0.75% Ropicvacaine)和 DICLO 组(n-50,全身镇痛,使用注射用双氯芬酸 75 毫克。两组的疗效均通过视觉类比量表进行评估。两组的起效时间无明显差异。结果与总结:FNB 组的作用持续时间(5.58±1.08 小时)长于 DICLO 组(3.40±1.20 小时)。视觉模拟评分显示,与 DICLO 组相比,FNB 组在 15 分钟后和 6 小时后疼痛明显减轻(P=0.001):结论:与全身静脉镇痛相比,股神经阻滞术在股骨骨折患者的急性疼痛治疗中安全、简单、有效。
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