Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104821
Lidan Zhang, Ping Diao, Xian Jiang
Significance
Subcutaneous high-flow port-wine stains pose a challenge in clinical treatment due to their rapid blood flow, which has resulted in poor therapeutic outcomes with hematoporphyrin-based photodynamic therapy in the past.
Approach
Before and after treatment, patients underwent skin lesion evaluation using Doppler ultrasound, VISIA imaging, and photography. All results were evaluated by three blinded dermatologists for clinical response(excellent ≥75%, good 50-74%, fair 25-49%) poor 1-24%, and no improvement).
Results
After two sessions of sclerotherapy, Doppler ultrasound evaluation indicated that the subcutaneous blood flow signals in the lesions had largely disappeared. Following HMME-PDT, the patient achieved highly satisfactory results, with a 25% reduction in lesion size and more than a 50% improvement in color fading.
Conclusions
The combination of sclerotherapy with HMME-PDT is a new option for high-flow signals PWSs.
{"title":"A combination of subcutaneous sclerotherapy and hematoporphyrin monomethyl ether photodynamic therapy: An exploration of treatment for subcutaneous high-flow port-wine stains","authors":"Lidan Zhang, Ping Diao, Xian Jiang","doi":"10.1016/j.pdpdt.2025.104821","DOIUrl":"10.1016/j.pdpdt.2025.104821","url":null,"abstract":"<div><h3>Significance</h3><div>Subcutaneous high-flow port-wine stains pose a challenge in clinical treatment due to their rapid blood flow, which has resulted in poor therapeutic outcomes with hematoporphyrin-based photodynamic therapy in the past.</div></div><div><h3>Approach</h3><div>Before and after treatment, patients underwent skin lesion evaluation using Doppler ultrasound, VISIA imaging, and photography. All results were evaluated by three blinded dermatologists for clinical response(excellent ≥75%, good 50-74%, fair 25-49%) poor 1-24%, and no improvement).</div></div><div><h3>Results</h3><div>After two sessions of sclerotherapy, Doppler ultrasound evaluation indicated that the subcutaneous blood flow signals in the lesions had largely disappeared. Following HMME-PDT, the patient achieved highly satisfactory results, with a 25% reduction in lesion size and more than a 50% improvement in color fading.</div></div><div><h3>Conclusions</h3><div>The combination of sclerotherapy with HMME-PDT is a new option for high-flow signals PWSs.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104821"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104824
Weibing Yang , Madelyn Johnson , Baozhu Lu , Hongjing Sun , Busch Theresa , Robert H. Hadfield , Brian C. Wilson , Timothy C. Zhu
Significance
Direct detection of singlet-state oxygen (¹O₂) is critical in type II photodynamic therapy (PDT) but remains challenging due to its short lifetime. Our cost-effective and user-friendly Multispectral Singlet Oxygen Dosimetry (MSOLD) system facilitates real-time detection of ¹O₂ with precision and ease, underscoring the importance of validating its accuracy against the established Singlet Oxygen Explicit Dosimetry (SOED) model.
Approach
A 690 nm laser excited benzoporphyrin derivative (2 - 6 mg/kg) in liquid phantom, Real-time ¹O₂ spectra were recorded for 900 seconds using an Avantes spectrometer. Ground-state oxygen, photosensitizer concentrations, and fluence rates were measured for SOED calculations.
Results
Both the MSOLD and SOED signals exhibit decay over the course of the PDT treatment. Instantaneous and cumulative ¹O₂ signals measured with MSOLD showed strong linear correlations with SOED results.
Conclusions
This study demonstrates that the ¹O₂ signal detected by MSOLD can be effectively utilized for PDT dosimetry, comparable to the capabilities of SOED.
{"title":"Comparative Analysis of Multispectral Singlet Oxygen Dosimetry (MSOLD) and Singlet Oxygen Explicit Dosimetry (SOED) in Type II Photodynamic Therapy","authors":"Weibing Yang , Madelyn Johnson , Baozhu Lu , Hongjing Sun , Busch Theresa , Robert H. Hadfield , Brian C. Wilson , Timothy C. Zhu","doi":"10.1016/j.pdpdt.2025.104824","DOIUrl":"10.1016/j.pdpdt.2025.104824","url":null,"abstract":"<div><h3>Significance</h3><div>Direct detection of singlet-state oxygen (¹O₂) is critical in type II photodynamic therapy (PDT) but remains challenging due to its short lifetime. Our cost-effective and user-friendly Multispectral Singlet Oxygen Dosimetry (MSOLD) system facilitates real-time detection of ¹O₂ with precision and ease, underscoring the importance of validating its accuracy against the established Singlet Oxygen Explicit Dosimetry (SOED) model.</div></div><div><h3>Approach</h3><div>A 690 nm laser excited benzoporphyrin derivative (2 - 6 mg/kg) in liquid phantom, Real-time ¹O₂ spectra were recorded for 900 seconds using an Avantes spectrometer. Ground-state oxygen, photosensitizer concentrations, and fluence rates were measured for SOED calculations.</div></div><div><h3>Results</h3><div>Both the MSOLD and SOED signals exhibit decay over the course of the PDT treatment. Instantaneous and cumulative ¹O₂ signals measured with MSOLD showed strong linear correlations with SOED results.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that the ¹O₂ signal detected by MSOLD can be effectively utilized for PDT dosimetry, comparable to the capabilities of SOED.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104824"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104792
Zong Jie Cui, Xiao Bing Xie, Yu Shu, Wei Mei Huang, Peng Juan Li
UVA is known to elicit calcium oscillations in rodent mast cells, due to activation of NOX2. Different from multi-subunit NOX2, NOX5 is a single subunit NOX, therefore is chosen here to study. Human NOX5 is expressed in rodent cell line CHO-K1 and effect of UVA irradiation is examined by Fura-2 fluorescent calcium imaging. UVA (380 nm) is found to induce repetitive calcium spikes in NOX5-CHO-K1 cells, which are inhibited by NOX inhibitor DPI and blocked by 1O2 quencher Trolox-C. A brief pulse of photodynamic action with SALPC (675 nm) in NOX5-CHO-K1, or with miniSOG (450 nm) in miniSOG-NOX5-CHO-K1 cells, both induce persistent calcium oscillations, which are blocked by DPI and Trolox-C. These data together suggest that NOX5 can be activated permanently with a brief pulse of photodynamic action (UVA irradiation, blue or red light with exogenous photosensitizer miniSOG or SALPC); photodynamic activation might be similarly applied to other NOX enzymes.
{"title":"To activate NAD(P)H oxidase with a brief pulse of photodynamic action","authors":"Zong Jie Cui, Xiao Bing Xie, Yu Shu, Wei Mei Huang, Peng Juan Li","doi":"10.1016/j.pdpdt.2025.104792","DOIUrl":"10.1016/j.pdpdt.2025.104792","url":null,"abstract":"<div><div>UVA is known to elicit calcium oscillations in rodent mast cells, due to activation of NOX2. Different from multi-subunit NOX2, NOX5 is a single subunit NOX, therefore is chosen here to study. Human NOX5 is expressed in rodent cell line CHO-K1 and effect of UVA irradiation is examined by Fura-2 fluorescent calcium imaging. UVA (380 nm) is found to induce repetitive calcium spikes in NOX5-CHO-K1 cells, which are inhibited by NOX inhibitor DPI and blocked by 1O2 quencher Trolox-C. A brief pulse of photodynamic action with SALPC (675 nm) in NOX5-CHO-K1, or with miniSOG (450 nm) in miniSOG-NOX5-CHO-K1 cells, both induce persistent calcium oscillations, which are blocked by DPI and Trolox-C. These data together suggest that NOX5 can be activated permanently with a brief pulse of photodynamic action (UVA irradiation, blue or red light with exogenous photosensitizer miniSOG or SALPC); photodynamic activation might be similarly applied to other NOX enzymes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104792"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104794
Edagul Ulucay, Periklis Pantazis
Bioharmonophores are a new class of biodegradable optical imaging nanoprobes that generate a bright second harmonic (SHG) signal without blinking, bleaching, or saturation. They consist of polymer-encapsulated, self-assembling peptides that create this strong SHG signal by combining two photons to form a photon with twice the energy and half the wavelength.
Oesophageal cancer is the eighth most common cancer worldwide, yet the sixth leading cause of cancer death due to poor prognosis and high mortality rates. Survival rates have remained unsatisfactory; highlighting the need to improve current therapeutic approaches. Photodynamic therapy (PDT) is a non-invasive treatment for oesophageal adenocarcinoma (OAC).
This study enhanced PDT using bioharmonophores dual-conjugated with met-pep1 (targeting HGFR overexpressed in OAC) and protoporphyrin IX (PpIX). This conjugation increased bioharmonophore accumulation in OAC cells, enabling precise, targeted PDT. Upon two-photon illumination, OAC cells and organoids produced greater reactive oxygen species and experienced greater cell death, improving treatment efficacy.
{"title":"Precise Photodynamic Therapy Of Oesophageal Cancer Using Bioharmonophores","authors":"Edagul Ulucay, Periklis Pantazis","doi":"10.1016/j.pdpdt.2025.104794","DOIUrl":"10.1016/j.pdpdt.2025.104794","url":null,"abstract":"<div><div>Bioharmonophores are a new class of biodegradable optical imaging nanoprobes that generate a bright second harmonic (SHG) signal without blinking, bleaching, or saturation. They consist of polymer-encapsulated, self-assembling peptides that create this strong SHG signal by combining two photons to form a photon with twice the energy and half the wavelength.</div><div>Oesophageal cancer is the eighth most common cancer worldwide, yet the sixth leading cause of cancer death due to poor prognosis and high mortality rates. Survival rates have remained unsatisfactory; highlighting the need to improve current therapeutic approaches. Photodynamic therapy (PDT) is a non-invasive treatment for oesophageal adenocarcinoma (OAC).</div><div>This study enhanced PDT using bioharmonophores dual-conjugated with met-pep1 (targeting HGFR overexpressed in OAC) and protoporphyrin IX (PpIX). This conjugation increased bioharmonophore accumulation in OAC cells, enabling precise, targeted PDT. Upon two-photon illumination, OAC cells and organoids produced greater reactive oxygen species and experienced greater cell death, improving treatment efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104794"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.105266
Fang Liu , Qian Wang , Ying Li , Wenwen Lin , Ruimin Zhang , Hui Huang , He Zhu , Luying Qiao , Weiguang Zhang , Ying Zheng , Xueying Cao , Yong Wang , Guangyan Cai , Xiangmei Chen , Zheyi Dong
Purpose
This study aimed to assess associations between macular thickness and pathologically confirmed diabetic nephropathy (DN).
Methods
This study included adult patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) who had undergone renal biopsy. Patients were classified based on pathological diagnosis, univariate and multivariable regression analyses were performed to evaluate associations between macular thickness and pathologically diagnosed DN.
Results
A total of 206 patients meeting the inclusion and exclusion criteria were finally included in the study. We classified the patients into three categories: Isolated DN (n = 55), Isolated non-diabetic renal disease (NDRD) (n = 94), and DN combined with NDRD (n = 57). The results indicated that patients with DN had significantly increased retinal thickness. Multivariate binary logistic regression showed that diabetes duration, smoking, diabetic retinopathy (DR), fibrinogen, low-density lipoprotein cholesterol (LDL-C), outer temporal macular thickness were independently associated with DN (P < 0.05). The relationship between outer temporal macular thickness and DN was significant regardless of whether the combined group was included in DN or NDRD, and the diagnostic efficiency of the model was improved when the combined group was excluded.
Conclusions
Retinal macular thickness is important for the rapid and non-invasive differentiation of DN from NDRD.
{"title":"Macular thickness is associated with pathologically confirmed diabetic nephropathy","authors":"Fang Liu , Qian Wang , Ying Li , Wenwen Lin , Ruimin Zhang , Hui Huang , He Zhu , Luying Qiao , Weiguang Zhang , Ying Zheng , Xueying Cao , Yong Wang , Guangyan Cai , Xiangmei Chen , Zheyi Dong","doi":"10.1016/j.pdpdt.2025.105266","DOIUrl":"10.1016/j.pdpdt.2025.105266","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to assess associations between macular thickness and pathologically confirmed diabetic nephropathy (DN).</div></div><div><h3>Methods</h3><div>This study included adult patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) who had undergone renal biopsy. Patients were classified based on pathological diagnosis, univariate and multivariable regression analyses were performed to evaluate associations between macular thickness and pathologically diagnosed DN.</div></div><div><h3>Results</h3><div>A total of 206 patients meeting the inclusion and exclusion criteria were finally included in the study. We classified the patients into three categories: Isolated DN (<em>n</em> = 55), Isolated non-diabetic renal disease (NDRD) (<em>n</em> = 94), and DN combined with NDRD (<em>n</em> = 57). The results indicated that patients with DN had significantly increased retinal thickness. Multivariate binary logistic regression showed that diabetes duration, smoking, diabetic retinopathy (DR), fibrinogen, low-density lipoprotein cholesterol (LDL-C), outer temporal macular thickness were independently associated with DN (<em>P</em> < 0.05). The relationship between outer temporal macular thickness and DN was significant regardless of whether the combined group was included in DN or NDRD, and the diagnostic efficiency of the model was improved when the combined group was excluded.</div></div><div><h3>Conclusions</h3><div>Retinal macular thickness is important for the rapid and non-invasive differentiation of DN from NDRD.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105266"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104876
Il Lae JUNG, Seul I KIM
Significance
The poor water solubility of the photosensitizer used in photodynamic therapy necessitates its dissolution in toxic organic solvents, resulting in severe side effects that hinder direct clinical applications.
Approach
To address this challenge, a two-step strategy was employed:
1.
Solubilization Buffer Development: A novel solubilization buffer comprising low-concentration Dimethyl Sulfoxide (DMSO) and Hydrochloric Acid (HCl) was developed.
2.
Exosome Loading Method: The solubilized photosensitizer was loaded into exosomes.
Results
The outcome revealed that approximately 30% of the photosensitizer, MPP100, was effectively loaded into the exosomes. Furthermore, when these exosomes were exposed to light in the presence of lung cancer cells, they demonstrated excellent photodynamic therapeutic effects without any observed toxicity issues.
Conclusions
The development of this novel solubilization buffer and efficient loading method could significantly enhance the safety and efficacy of photodynamic therapy, paving the way for more effective treatment strategies against human diseases.
{"title":"A non-toxic, exosome-loaded photosensitizer demonstrates effective anticancer efficacy","authors":"Il Lae JUNG, Seul I KIM","doi":"10.1016/j.pdpdt.2025.104876","DOIUrl":"10.1016/j.pdpdt.2025.104876","url":null,"abstract":"<div><h3>Significance</h3><div>The poor water solubility of the photosensitizer used in photodynamic therapy necessitates its dissolution in toxic organic solvents, resulting in severe side effects that hinder direct clinical applications.</div></div><div><h3>Approach</h3><div>To address this challenge, a two-step strategy was employed:<ul><li><span>1.</span><span><div>Solubilization Buffer Development: A novel solubilization buffer comprising low-concentration Dimethyl Sulfoxide (DMSO) and Hydrochloric Acid (HCl) was developed.</div></span></li><li><span>2.</span><span><div>Exosome Loading Method: The solubilized photosensitizer was loaded into exosomes.</div></span></li></ul></div></div><div><h3>Results</h3><div>The outcome revealed that approximately 30% of the photosensitizer, MPP100, was effectively loaded into the exosomes. Furthermore, when these exosomes were exposed to light in the presence of lung cancer cells, they demonstrated excellent photodynamic therapeutic effects without any observed toxicity issues.</div></div><div><h3>Conclusions</h3><div>The development of this novel solubilization buffer and efficient loading method could significantly enhance the safety and efficacy of photodynamic therapy, paving the way for more effective treatment strategies against human diseases.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104876"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104884
Natalia Mayumi Inada , Flavia Langellotti Silva , Laura Marchetti , Mariana Pasqualotti Sena , Mirian Denise Stringasci , Welington Lombardi , Cynthia Aparecida de Castro , Vanderlei Salvador Bagnato
Significance
Cervical Intraepithelial Neoplasia (CIN) is the precursor of cervical cancer, the fourth most common cancer in women globally. Excisional techniques such as high-frequency surgery are recommended but can carry risk to woman and a future pregnancy.
Approach
This clinical trial offers an individualized treatment with Photodynamic Therapy (PDT), starting with two PDT sessions, 21 days apart and performing colposcopy and hybrid capture 90 days after the 1st session. The patient will continue with two other sessions of PDT if the viral load of high-risk HPV has decreased by at least 50%.
Results
The most promising protocol in a previously clinical trial presents benefits with two PDT sessions twenty-one days apart. The results will now be complemented with PCR, p16 and Ki-67.
Conclusions
Two PDT sessions with a 21-day interval have shown promise for colposcopic findings favorable to cure, as well as for reducing viral load by more than 50%.
{"title":"Personalized high-grade CIN treatment with photodynamic therapy and preventing cervical cancer","authors":"Natalia Mayumi Inada , Flavia Langellotti Silva , Laura Marchetti , Mariana Pasqualotti Sena , Mirian Denise Stringasci , Welington Lombardi , Cynthia Aparecida de Castro , Vanderlei Salvador Bagnato","doi":"10.1016/j.pdpdt.2025.104884","DOIUrl":"10.1016/j.pdpdt.2025.104884","url":null,"abstract":"<div><h3>Significance</h3><div>Cervical Intraepithelial Neoplasia (CIN) is the precursor of cervical cancer, the fourth most common cancer in women globally. Excisional techniques such as high-frequency surgery are recommended but can carry risk to woman and a future pregnancy.</div></div><div><h3>Approach</h3><div>This clinical trial offers an individualized treatment with Photodynamic Therapy (PDT), starting with two PDT sessions, 21 days apart and performing colposcopy and hybrid capture 90 days after the 1st session. The patient will continue with two other sessions of PDT if the viral load of high-risk HPV has decreased by at least 50%.</div></div><div><h3>Results</h3><div>The most promising protocol in a previously clinical trial presents benefits with two PDT sessions twenty-one days apart. The results will now be complemented with PCR, p16 and Ki-67.</div></div><div><h3>Conclusions</h3><div>Two PDT sessions with a 21-day interval have shown promise for colposcopic findings favorable to cure, as well as for reducing viral load by more than 50%.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104884"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104855
Di Zhang, Xiang Nong, Shuangyun Xu, Lunrong Nie
Queyrat erythroplasia (EQ) is a rare form of squamous cell carcinoma (SCC) in situ, commonly found on the glans, penis, and coronary sulcus, and clinically presenting as one or more well-marginated erythematous velvety plaques. EQ can transform into invasive SCC and requires early diagnosis and treatment. Photodynamic diagnosis (PDD) is a fluorescence imaging technique that can be used for a wide range of non-pigmented skin tumours, helping us to diagnose skin tumours and monitor efficacy. Here, we report a case of EQ successfully treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) assisted by PDD technology, suggesting that PDD technology has a role in the treatment and diagnosis of patients with EQ.
{"title":"Photodynamic diagnosis-guided treatment of Erythroplasia of Queyrat with ALA-PDT: A case report","authors":"Di Zhang, Xiang Nong, Shuangyun Xu, Lunrong Nie","doi":"10.1016/j.pdpdt.2025.104855","DOIUrl":"10.1016/j.pdpdt.2025.104855","url":null,"abstract":"<div><div>Queyrat erythroplasia (EQ) is a rare form of squamous cell carcinoma (SCC) in situ, commonly found on the glans, penis, and coronary sulcus, and clinically presenting as one or more well-marginated erythematous velvety plaques. EQ can transform into invasive SCC and requires early diagnosis and treatment. Photodynamic diagnosis (PDD) is a fluorescence imaging technique that can be used for a wide range of non-pigmented skin tumours, helping us to diagnose skin tumours and monitor efficacy. Here, we report a case of EQ successfully treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) assisted by PDD technology, suggesting that PDD technology has a role in the treatment and diagnosis of patients with EQ.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104855"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104863
Lu Zhang, Qing Cong
Objectives
To explore the value of CO2 laser, photodynamic therapy, and follow-up observationin the management of cervical low-grade squamous intraepithelial lesions (LSIL).
Methods
Women diagnosed with cervical LSIL and high risk human papillomavirus(HR-HPV) infection were collected and the complete remission rate(CRR) and HR-HPV clearance rate were compared during the 6-12 month follow-up.
Results
At the 6-12 month follow-up, the CRR was 89.7% in the laser group, slightly higher than the 86.9% in the photodynamic group, P=0.523. However, both were significantly higher than the 64.4% in the follow-up group. The HR-HPV clearance rates in the laser and photodynamic groups were 73.8% and 68.2%, respectively, both significantly higher than the 32.7% in the follow-up group, with no statistical difference between the laser and photodynamic groups, P=0.366.
Conclusions
CO2 laser and photodynamic therapy are effective treatments for cervical LSIL, significantly superior to follow-up observation in terms of CRR and HPV clearance rates.
{"title":"Value of laser, photodynamic therapy, and follow-up observation in the management of cervical low-grade squamous intraepithelial lesions: a prospective cohort study","authors":"Lu Zhang, Qing Cong","doi":"10.1016/j.pdpdt.2025.104863","DOIUrl":"10.1016/j.pdpdt.2025.104863","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore the value of CO2 laser, photodynamic therapy, and follow-up observationin the management of cervical low-grade squamous intraepithelial lesions (LSIL).</div></div><div><h3>Methods</h3><div>Women diagnosed with cervical LSIL and high risk human papillomavirus(HR-HPV) infection were collected and the complete remission rate(CRR) and HR-HPV clearance rate were compared during the 6-12 month follow-up.</div></div><div><h3>Results</h3><div>At the 6-12 month follow-up, the CRR was 89.7% in the laser group, slightly higher than the 86.9% in the photodynamic group, P=0.523. However, both were significantly higher than the 64.4% in the follow-up group. The HR-HPV clearance rates in the laser and photodynamic groups were 73.8% and 68.2%, respectively, both significantly higher than the 32.7% in the follow-up group, with no statistical difference between the laser and photodynamic groups, P=0.366.</div></div><div><h3>Conclusions</h3><div>CO2 laser and photodynamic therapy are effective treatments for cervical LSIL, significantly superior to follow-up observation in terms of CRR and HPV clearance rates.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104863"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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