{"title":"Commentary on “Combination treatment with photodynamic therapy and antibiotic in refractory cutaneous nocardiosis: A case report”","authors":"Manizhe Khosravi , Salehoddin Bouya , Masoud Keikha","doi":"10.1016/j.pdpdt.2025.104501","DOIUrl":"10.1016/j.pdpdt.2025.104501","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104501"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-30DOI: 10.1016/j.pdpdt.2025.104507
Paulo Cezar de Moraes , Maria Lúcia Scroferneker , Alessandra Koehler , Letícia Maria Eidt , Cristiane Almeida Soares Cattani , Valeriano Antonio Corbellini
Leprosy is an infectious disease caused by the Mycobacterium leprae complex. Although the diagnosis of this disease is clinical, additional tests are often needed. One of the most common tests is intradermal smear bacilloscopy, which detects the patient's bacillary load. However, bacilloscopy is an invasive test and its results are subjective. The aim of this study was to propose a methodology based on Fourier transform infrared (FTIR) spectroscopy to predict the bacilloscopic index in the saliva of leprosy patients. A total of 88 saliva samples were included, and the bacilloscopic index of the patients was previously defined by intradermal smear bacilloscopy. The saliva samples were analyzed by attenuated total reflection (ATR)-FTIR; a supervised analysis with partial least squares regression (PLS), after orthogonal signal correction (OSC), was used to predict the bacilloscopic index. The PLS model with three latent variables and one OSC component obtained a coefficient of determination greater than 0.9999 in both the calibration and prediction sets. The model was able to predict the bacilloscopic indexes with a minimum error, demonstrating its robustness. Thus, modeling with ATR/FTIR and multivariate calibration using one OSC component showed high accuracy and reproducibility, overcoming the limitations of intradermal smear bacilloscopy and proving to be a promising method in the clinical management of patients with leprosy.
{"title":"Use of Fourier transform infrared spectroscopy and chemometric analysis to predict the bacilloscopic index in the saliva of leprosy patients","authors":"Paulo Cezar de Moraes , Maria Lúcia Scroferneker , Alessandra Koehler , Letícia Maria Eidt , Cristiane Almeida Soares Cattani , Valeriano Antonio Corbellini","doi":"10.1016/j.pdpdt.2025.104507","DOIUrl":"10.1016/j.pdpdt.2025.104507","url":null,"abstract":"<div><div>Leprosy is an infectious disease caused by the <em>Mycobacterium leprae</em> complex. Although the diagnosis of this disease is clinical, additional tests are often needed. One of the most common tests is intradermal smear bacilloscopy, which detects the patient's bacillary load. However, bacilloscopy is an invasive test and its results are subjective. The aim of this study was to propose a methodology based on Fourier transform infrared (FTIR) spectroscopy to predict the bacilloscopic index in the saliva of leprosy patients. A total of 88 saliva samples were included, and the bacilloscopic index of the patients was previously defined by intradermal smear bacilloscopy. The saliva samples were analyzed by attenuated total reflection (ATR)-FTIR; a supervised analysis with partial least squares regression (PLS), after orthogonal signal correction (OSC), was used to predict the bacilloscopic index. The PLS model with three latent variables and one OSC component obtained a coefficient of determination greater than 0.9999 in both the calibration and prediction sets. The model was able to predict the bacilloscopic indexes with a minimum error, demonstrating its robustness. Thus, modeling with ATR/FTIR and multivariate calibration using one OSC component showed high accuracy and reproducibility, overcoming the limitations of intradermal smear bacilloscopy and proving to be a promising method in the clinical management of patients with leprosy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104507"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-27DOI: 10.1016/j.pdpdt.2025.104498
Yugo Minegishi, Yasutomo Nomura
Introduction
The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent. In the PDT simulation, Upconversion nanoparticles-Quantum dots-Rose bengal (UCQR) which was a PDT agent with upconversion capabilities was used.
Methods
The feasibility of breast cancer diagnosis and treatment using our proposed method is evaluated through Monte Carlo simulations of exact light transport through a realistic breast model in the prone position. Monte Carlo modeling in voxelized media was performed. Fluorescence propagation from the tumor and the amount of singlet oxygen produced within the tumor were estimated from the calculated fluence. Next, the effects of tumor diameter and depth from the skin surface on the simulation results were evaluated.
Results
The simulation results showed successful detection of tumors with diameters of 5–9 mm in the 15–25 mm depth region, where tumors are commonly found. Furthermore, simulations have estimated that those tumors can be completely treated by PDT with less than ten light irradiations.
Conclusion
This study suggests that fluorescent molecular imaging-guided photodynamic therapy may be a potential treatment for early-stage breast cancer. Our method would be more suitable than the conventional method for young women who are at higher risk of radiation exposure effects.
{"title":"Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations","authors":"Yugo Minegishi, Yasutomo Nomura","doi":"10.1016/j.pdpdt.2025.104498","DOIUrl":"10.1016/j.pdpdt.2025.104498","url":null,"abstract":"<div><h3>Introduction</h3><div>The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent. In the PDT simulation, Upconversion nanoparticles-Quantum dots-Rose bengal (UCQR) which was a PDT agent with upconversion capabilities was used.</div></div><div><h3>Methods</h3><div>The feasibility of breast cancer diagnosis and treatment using our proposed method is evaluated through Monte Carlo simulations of exact light transport through a realistic breast model in the prone position. Monte Carlo modeling in voxelized media was performed. Fluorescence propagation from the tumor and the amount of singlet oxygen produced within the tumor were estimated from the calculated fluence. Next, the effects of tumor diameter and depth from the skin surface on the simulation results were evaluated.</div></div><div><h3>Results</h3><div>The simulation results showed successful detection of tumors with diameters of 5–9 mm in the 15–25 mm depth region, where tumors are commonly found. Furthermore, simulations have estimated that those tumors can be completely treated by PDT with less than ten light irradiations.</div></div><div><h3>Conclusion</h3><div>This study suggests that fluorescent molecular imaging-guided photodynamic therapy may be a potential treatment for early-stage breast cancer. Our method would be more suitable than the conventional method for young women who are at higher risk of radiation exposure effects.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104498"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-27DOI: 10.1016/j.pdpdt.2025.104493
Yanyan Zhang , Yan Zhong , Wei Mao , Zhe Zhang , Yusheng Zhou , Hu Li , Jianing Ying , Quanyong Yi
Purpose
To evaluate the differences in fundus tessellation among various severities using multifocal visual electrophysiology (MfERG) and optical coherence tomography angiography (OCTA) for clinical grading and treatment.
Methods
This study included 52 patients totaling 87 eyes. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid division method was utilized to assess Grade of fundus tessellation. Data obtained via OCTA and ImageJ software included macular foveal thickness (MT), subfoveal choroidal thickness (SFCT), superficial retinal capillary layer vascular density (SVD), deep retinal capillary layer vascular density (DVD), and choroidal blood capillary layer blood flow density (CFD). Multifocal visual electrophysiology equipment provided latency and amplitude of N1 and P1 waves. Differences and changes among the four Grade of fundus tessellation grading were compared, and ROC curve analysis was performed to identify the optimal choroidal thickness indicators for predicting the grading of fundus tessellation.
Results
SFCT tends to decrease as the grade of fundus tessellation increases. and the amplitudes of N1 and P1 waves in multifocal electroretinography reduce, with an elongation in their latency periods. Correlation analysis showed that SFCT positively correlated with N1 and P1 amplitudes (r = 0.270, 0.246; P < 0.05) and negatively correlated with their latency periods (r=-0.219, -0.248; P < 0.05). The ROC curve results indicated the cutoff values for SFCT were 192.75 µm between Grade 1 and 2, 162 µm between Grade 2 and 3, and 130.75 µm between Grade 3 and 4.
Conclusion
Assessment in fundus tessellation using MfERG and OCTA contributes to objective grading of fundus tessellation and further help to clinical prediction and treatment.
Translational relevance
Assessment in fundus tessellation morphologically and functionally using MfERG and OCTA contributes to classification and clinical prediction of fundus tessellation.
{"title":"Clinical features evaluation of myopic fundus tessellation from OCTA and MfERG","authors":"Yanyan Zhang , Yan Zhong , Wei Mao , Zhe Zhang , Yusheng Zhou , Hu Li , Jianing Ying , Quanyong Yi","doi":"10.1016/j.pdpdt.2025.104493","DOIUrl":"10.1016/j.pdpdt.2025.104493","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the differences in fundus tessellation among various severities using multifocal visual electrophysiology (MfERG) and optical coherence tomography angiography (OCTA) for clinical grading and treatment.</div></div><div><h3>Methods</h3><div>This study included 52 patients totaling 87 eyes. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid division method was utilized to assess Grade of fundus tessellation. Data obtained via OCTA and ImageJ software included macular foveal thickness (MT), subfoveal choroidal thickness (SFCT), superficial retinal capillary layer vascular density (SVD), deep retinal capillary layer vascular density (DVD), and choroidal blood capillary layer blood flow density (CFD). Multifocal visual electrophysiology equipment provided latency and amplitude of N1 and P1 waves. Differences and changes among the four Grade of fundus tessellation grading were compared, and ROC curve analysis was performed to identify the optimal choroidal thickness indicators for predicting the grading of fundus tessellation.</div></div><div><h3>Results</h3><div>SFCT tends to decrease as the grade of fundus tessellation increases. and the amplitudes of N1 and P1 waves in multifocal electroretinography reduce, with an elongation in their latency periods. Correlation analysis showed that SFCT positively correlated with N1 and P1 amplitudes (<em>r</em> = 0.270, 0.246; <em>P</em> < 0.05) and negatively correlated with their latency periods (<em>r</em>=-0.219, -0.248; <em>P</em> < 0.05). The ROC curve results indicated the cutoff values for SFCT were 192.75 µm between Grade 1 and 2, 162 µm between Grade 2 and 3, and 130.75 µm between Grade 3 and 4.</div></div><div><h3>Conclusion</h3><div>Assessment in fundus tessellation using MfERG and OCTA contributes to objective grading of fundus tessellation and further help to clinical prediction and treatment.</div></div><div><h3>Translational relevance</h3><div>Assessment in fundus tessellation morphologically and functionally using MfERG and OCTA contributes to classification and clinical prediction of fundus tessellation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104493"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-26DOI: 10.1016/j.pdpdt.2025.104485
Shiyi Yin , Jinyuan Wang , Haihan Zhang , Xuan Yang , Jingting Luo , Wenbin Wei
Purpose
Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.
Methods
This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed.
Results
By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (P < 0.05), whereas differences between stages 2 and 3 were not statistically significant (P > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (P > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (P < 0.001). Multivariate regression analysis revealed that SVC-VD (P < 0.001), SVC-PA (P < 0.001) and choroid-PA (P = 0.030) were significantly associated with BCVA, while DVC-VD (P = 0.014), outer retinal thickness (P = 0.011), and CVI (P = 0.004) were significantly associated with visual field damage.
Conclusions
SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.
{"title":"Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy","authors":"Shiyi Yin , Jinyuan Wang , Haihan Zhang , Xuan Yang , Jingting Luo , Wenbin Wei","doi":"10.1016/j.pdpdt.2025.104485","DOIUrl":"10.1016/j.pdpdt.2025.104485","url":null,"abstract":"<div><h3>Purpose</h3><div>Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed.</div></div><div><h3>Results</h3><div>By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (<em>P</em> < 0.05), whereas differences between stages 2 and 3 were not statistically significant (<em>P</em> > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (<em>P</em> > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (<em>P</em> < 0.001). Multivariate regression analysis revealed that SVC-VD (<em>P</em> < 0.001), SVC-PA (<em>P</em> < 0.001) and choroid-PA (<em>P</em> = 0.030) were significantly associated with BCVA, while DVC-VD (<em>P</em> = 0.014), outer retinal thickness (<em>P</em> = 0.011), and CVI (<em>P</em> = 0.004) were significantly associated with visual field damage.</div></div><div><h3>Conclusions</h3><div>SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104485"},"PeriodicalIF":3.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, it was planned to compare the macular ganglion cell analysis (GCA) and peripapillary retinal nerve fiber layer (pRNFL) of the patients with preperimetric glaucoma (PPG), early stage glaucoma (EG) and the control group.
Methods
This retrospective study included a total of 103 eyes: 38 from EG patients, 30 from PPG patients, and 35 from healthy individuals at Ankara Bilkent City Hospital Glaucoma Unit between January 2018 and September 2021. Eyes were categorized into control, PPG, and EG groups based on visual field (VF) classification. Topcon DRI Optical Coherence Tomography (OCT)-1, a Swept−Source OCT (SS-OCT), measured optic nerve head parameters, pRNFL, gangliyon cell inner plexiform layer (GCIPL), and ganglion cell complex (GCC) thickness. Glaucomatous defects were identified using also the SS-OCT SuperPixel map. Diagnostic efficacy of OCT parameters was assessed through area under the curve (AUC) values.
Results
All pRNFL and ganglion cell parameters in OCT showed significant differences between the control-PPG and control-EG groups (p < 0.05). GCIPL, GCC, and pRNFL thicknesses in the PPG and EG groups were significantly lower than those in the control group (p < 0.05). The mean pRNFL thickness emerged as the most valuable diagnostic parameter for distinguishing between the control and EG groups (p < 0.05). In the wide-field SuperPixel map, the frequency of glaucomatous defect detection was higher in the EG group than in the PPG group (p < 0.05). Mean pRNFL and mean GCIPL thicknesses exhibited the highest sensitivity and specificity for differentiating glaucoma groups from controls.
Conclusion
OCT parameters were not significantly superior to each other in control-PPG and control-EG. The evaluation of pRNFL and GCA together is still considered to be the most valid diagnostic method.
{"title":"Evaluation of macula ganglion cell analysis and retinal nerve fiber layer thickness in preperimetric glaucoma, early stage glaucoma and healthy individuals","authors":"Ozlem AKTAS OZALTUN , Ozlem GURBUZ KOZ , Ahmet Alper YARANGUMELI","doi":"10.1016/j.pdpdt.2025.104495","DOIUrl":"10.1016/j.pdpdt.2025.104495","url":null,"abstract":"<div><h3>Purpose</h3><div>In this study, it was planned to compare the macular ganglion cell analysis (GCA) and peripapillary retinal nerve fiber layer (pRNFL) of the patients with preperimetric glaucoma (PPG), early stage glaucoma (EG) and the control group.</div></div><div><h3>Methods</h3><div>This retrospective study included a total of 103 eyes: 38 from EG patients, 30 from PPG patients, and 35 from healthy individuals at Ankara Bilkent City Hospital Glaucoma Unit between January 2018 and September 2021. Eyes were categorized into control, PPG, and EG groups based on visual field (VF) classification. Topcon DRI Optical Coherence Tomography (OCT)-1, a Swept−Source OCT (SS-OCT), measured optic nerve head parameters, pRNFL, gangliyon cell inner plexiform layer (GCIPL), and ganglion cell complex (GCC) thickness. Glaucomatous defects were identified using also the SS-OCT SuperPixel map. Diagnostic efficacy of OCT parameters was assessed through area under the curve (AUC) values.</div></div><div><h3>Results</h3><div>All pRNFL and ganglion cell parameters in OCT showed significant differences between the control-PPG and control-EG groups (<em>p</em> < 0.05). GCIPL, GCC, and pRNFL thicknesses in the PPG and EG groups were significantly lower than those in the control group (<em>p</em> < 0.05). The mean pRNFL thickness emerged as the most valuable diagnostic parameter for distinguishing between the control and EG groups (<em>p</em> < 0.05). In the wide-field SuperPixel map, the frequency of glaucomatous defect detection was higher in the EG group than in the PPG group (<em>p</em> < 0.05). Mean pRNFL and mean GCIPL thicknesses exhibited the highest sensitivity and specificity for differentiating glaucoma groups from controls.</div></div><div><h3>Conclusion</h3><div>OCT parameters were not significantly superior to each other in control-PPG and control-EG. The evaluation of pRNFL and GCA together is still considered to be the most valid diagnostic method.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104495"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-23DOI: 10.1016/j.pdpdt.2025.104497
Min Li , Yuhao Shao , Lin Liu, Yuehui Shi, Lina Sun, Hua Li, Jun Zou
Purpose
This retrospective study aimed to investigate the subjective and objective visual outcomes following Small Incision Lenticule Extraction (SMILE) surgery in high myopic patients with varying axial lengths (AL).
Methods
The study enrolled 113 highly myopic patients (202 eyes) who underwent SMILE surgery at Shanghai's Tenth People's Hospital from July 2021 to September 2023. Patients were classified into three groups based on the axial length before surgery: Group A (AL < 26 mm, 62 eyes), Group B (26 mm ≤ AL < 27 mm, 88 eyes), and Group C (AL ≥ 27 mm, 52 eyes). Preoperative and postoperative evaluations included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), equivalent spherical error, and ocular higher-order aberrations. Subjective visual quality was assessed using the Quality of Vision (QoV) questionnaire.
Results
One year postoperatively, there were no notable differences found in safety, efficacy, or stability among the groups (P > 0.05). Postoperative spherical aberration, horizontal, and vertical coma increased compared to preoperative values and showed a positive association with axial length (P < 0.05). Horizontal and vertical trefoil remained stable at all follow-up points without any significant inter-group variances (P > 0.05). Postoperative QoV scores were obviously higher in Groups A (45.45 ± 5.49) and B (46.34 ± 3.25) compared to Group C (49.15 ± 7.89). There was no correlation between QoV scores and axial length observed. The induced horizontal trefoil showed a positive correlation with changes in lens thickness (LT) one year after SMILE (r = 0.22, p = 0.03).
Conclusions
SMILE surgery is a safe and effective approach for correcting high myopia, exhibiting a significant correlation observed between ocular high-order aberrations and axial length.
{"title":"The influence of axial length on visual quality following SMILE surgery in patients with high myopia","authors":"Min Li , Yuhao Shao , Lin Liu, Yuehui Shi, Lina Sun, Hua Li, Jun Zou","doi":"10.1016/j.pdpdt.2025.104497","DOIUrl":"10.1016/j.pdpdt.2025.104497","url":null,"abstract":"<div><h3>Purpose</h3><div>This retrospective study aimed to investigate the subjective and objective visual outcomes following Small Incision Lenticule Extraction (SMILE) surgery in high myopic patients with varying axial lengths (AL).</div></div><div><h3>Methods</h3><div>The study enrolled 113 highly myopic patients (202 eyes) who underwent SMILE surgery at Shanghai's Tenth People's Hospital from July 2021 to September 2023. Patients were classified into three groups based on the axial length before surgery: Group A (AL < 26 mm, 62 eyes), Group B (26 mm ≤ AL < 27 mm, 88 eyes), and Group C (AL ≥ 27 mm, 52 eyes). Preoperative and postoperative evaluations included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), equivalent spherical error, and ocular higher-order aberrations. Subjective visual quality was assessed using the Quality of Vision (QoV) questionnaire.</div></div><div><h3>Results</h3><div>One year postoperatively, there were no notable differences found in safety, efficacy, or stability among the groups (<em>P</em> > 0.05). Postoperative spherical aberration, horizontal, and vertical coma increased compared to preoperative values and showed a positive association with axial length (<em>P</em> < 0.05). Horizontal and vertical trefoil remained stable at all follow-up points without any significant inter-group variances (<em>P</em> > 0.05). Postoperative QoV scores were obviously higher in Groups A (45.45 ± 5.49) and B (46.34 ± 3.25) compared to Group C (49.15 ± 7.89). There was no correlation between QoV scores and axial length observed. The induced horizontal trefoil showed a positive correlation with changes in lens thickness (LT) one year after SMILE (<em>r</em> = 0.22, <em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>SMILE surgery is a safe and effective approach for correcting high myopia, exhibiting a significant correlation observed between ocular high-order aberrations and axial length.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104497"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent years have seen the use of photodynamic technologies concerning the detection and therapy of bladder cancer (BC) due to their rapid development and well-established therapeutic impact. However, a thorough analysis and bibliometric assessment of photodynamic technologies publishing trends in BC has not been completed yet.
Methods
Retrieving bibliographies from the Web of Science Core Collection limited the publication date to December 31, 2023, from January 1, 2004. We used VOSviewer (Version 1.6.19) and CiteSpace (Version 6.4 R1) for both statistical and visualization analysis.
Results
We selected a total of 870 documents for analysis. The yearly publication findings show notable upward patterns over the last two decades. The Kochi Medical School in Japan was the most productive school, while the USA was the most productive nation. Japanese researcher Inoue Keiji published the highest number of photodynamic -related articles in BC. The most quoted and prolific journals were the Photodynamic Therapy and Photodiagnosis. According to the keyword analysis, the terms "cystoscopy," "carcinoma in situ," "drug delivery," "follow-up," "hexaminolevulinate," and "impact" are all relatively recent and hot field.
Conclusions
Our investigation produced a bibliometric outcome for the field, potentially opening up new research opportunities. We suggest that future research concentrate on in-situ carcinoma identification, photosensitizer invention, medication delivery enhancement, and photodynamic technology follow-up in BC.
{"title":"Bibliometric analysis of photodynamic research in bladder cancer: Trends and future directions","authors":"Xi Xu , Jinshan Xu , Hongliang Gao , Zhaoyang Sheng , Yang Xu , Shuxiong Zeng , Guanghua Chen , Zhensheng Zhang","doi":"10.1016/j.pdpdt.2025.104494","DOIUrl":"10.1016/j.pdpdt.2025.104494","url":null,"abstract":"<div><h3>Background</h3><div>Recent years have seen the use of photodynamic technologies concerning the detection and therapy of bladder cancer (BC) due to their rapid development and well-established therapeutic impact. However, a thorough analysis and bibliometric assessment of photodynamic technologies publishing trends in BC has not been completed yet.</div></div><div><h3>Methods</h3><div>Retrieving bibliographies from the Web of Science Core Collection limited the publication date to December 31, 2023, from January 1, 2004. We used VOSviewer (Version 1.6.19) and CiteSpace (Version 6.4 R1) for both statistical and visualization analysis.</div></div><div><h3>Results</h3><div>We selected a total of 870 documents for analysis. The yearly publication findings show notable upward patterns over the last two decades. The Kochi Medical School in Japan was the most productive school, while the USA was the most productive nation. Japanese researcher Inoue Keiji published the highest number of photodynamic -related articles in BC. The most quoted and prolific journals were the <em>Photodynamic Therapy and Photodiagnosis</em>. According to the keyword analysis, the terms \"cystoscopy,\" \"carcinoma in situ,\" \"drug delivery,\" \"follow-up,\" \"hexaminolevulinate,\" and \"impact\" are all relatively recent and hot field.</div></div><div><h3>Conclusions</h3><div>Our investigation produced a bibliometric outcome for the field, potentially opening up new research opportunities. We suggest that future research concentrate on in-situ carcinoma identification, photosensitizer invention, medication delivery enhancement, and photodynamic technology follow-up in BC.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104494"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.pdpdt.2025.104496
Cheng Li, Xuanhui Wang, Qiulin Cui, Mian He, Ming Chen
Background
Non-invasive treatments, such as 5-Aminolevulinic acid photodynamic therapy (5-ALA-PDT), has gained increasing attention among women with cervical intraepithelial neoplasia grade 2 (CIN2) who have fertility requirements. To compare the effectiveness of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in patients with CIN2, we conducted this prospective cohort study in Chinese patients with CIN2.
Methods
229 patients with CIN2 were enrolled. They were divided into the PDT Group (n=94) and LEEP Group (n=135) according to the patient's willingness. Patients were evaluated at the 3-, 6-, 12- and 18-month follow-up periods, using cytology, HPV testing, and colposcopy examination.
Results
At the 3-month follow-up, the rates of disease regression to normal or CIN1 in the PDT group were 76.6% (72/94) and 13.8% (13/94), respectively, whereas in the LEEP group, they were 80.7% (109/135) and 11.1% (15/135), respectively. Logistic regression analysis revealed that the transformation zone type 3 was the only risk factor for both the PDT (OR=3.68; 95% CI, 2.43-5.26; P=0.008) and LEEP groups (OR=2.34; 95% CI, 1.84-4.53; P=0.02). The treatment efficacy in the PDT group increased gradually and peaked at the 18-month follow-up point with disease disappearance and regression rates of 90.4% and 8.5%, respectively. The disease disappearance and regression rates in the LEEP group were highest at the first half year posttreatment, with disease disappearance and regression rates of 87.4% and 12.6%, respectively. The hrHPV-negative rates in the PDT group and LEEP group were the highest at the 18-month follow-up (78.7% and 74.8%). There was no significant difference in the disappearance or regression rates between the two groups at the follow-up points (P > 0.05).
Conclusions
Our study revealed that both 5-ALA PDT therapy and LEEP were highly effective at treating CIN2. 5-ALA-PDT, as a non-invasive treatment, could be an effective option for CIN2 patients with fertility preservation needs.
{"title":"Comparison of photodynamic therapy and LEEP in women of reproductive age with cervical squamous intraepithelial neoplasia 2 (CIN2): A prospective observational study in China","authors":"Cheng Li, Xuanhui Wang, Qiulin Cui, Mian He, Ming Chen","doi":"10.1016/j.pdpdt.2025.104496","DOIUrl":"10.1016/j.pdpdt.2025.104496","url":null,"abstract":"<div><h3>Background</h3><div>Non-invasive treatments, such as 5-Aminolevulinic acid photodynamic therapy (5-ALA-PDT), has gained increasing attention among women with cervical intraepithelial neoplasia grade 2 (CIN2) who have fertility requirements. To compare the effectiveness of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in patients with CIN2, we conducted this prospective cohort study in Chinese patients with CIN2.</div></div><div><h3>Methods</h3><div>229 patients with CIN2 were enrolled. They were divided into the PDT Group (n=94) and LEEP Group (n=135) according to the patient's willingness. Patients were evaluated at the 3-, 6-, 12- and 18-month follow-up periods, using cytology, HPV testing, and colposcopy examination.</div></div><div><h3>Results</h3><div>At the 3-month follow-up, the rates of disease regression to normal or CIN1 in the PDT group were 76.6% (72/94) and 13.8% (13/94), respectively, whereas in the LEEP group, they were 80.7% (109/135) and 11.1% (15/135), respectively. Logistic regression analysis revealed that the transformation zone type 3 was the only risk factor for both the PDT (OR=3.68; 95% CI, 2.43-5.26; P=0.008) and LEEP groups (OR=2.34; 95% CI, 1.84-4.53; P=0.02). The treatment efficacy in the PDT group increased gradually and peaked at the 18-month follow-up point with disease disappearance and regression rates of 90.4% and 8.5%, respectively. The disease disappearance and regression rates in the LEEP group were highest at the first half year posttreatment, with disease disappearance and regression rates of 87.4% and 12.6%, respectively. The hrHPV-negative rates in the PDT group and LEEP group were the highest at the 18-month follow-up (78.7% and 74.8%). There was no significant difference in the disappearance or regression rates between the two groups at the follow-up points (<em>P</em> > 0.05).</div></div><div><h3>Conclusions</h3><div>Our study revealed that both 5-ALA PDT therapy and LEEP were highly effective at treating CIN2. 5-ALA-PDT, as a non-invasive treatment, could be an effective option for CIN2 patients with fertility preservation needs.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104496"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-18DOI: 10.1016/j.pdpdt.2025.104490
Abdulaziz Alsahhaf
Aim
To investigate the effectiveness of unconventional post space disinfection techniques, specifically Er:YAG laser, Temoporfin, and Carbon Nanoparticles (CNPs), in improving Martens hardness (MH), eliminating the smear layer (SL), and enhancing the push-out bond strength (PBS) of glass fiber posts in canal dentin.
Methods
An in vitro study was conducted utilizing 80 single-rooted extracted human teeth, which were decoronated and subjected to standardized root canal preparation. The teeth were equally distributed into four experimental groups: Group 1 (NaOCl + EDTA), Group 2 (Er: YAG laser + EDTA), Group 3 (Temoporfin + EDTA), and Group 4 (CNPs + EDTA). Each group underwent disinfection protocols followed by assessment of Martens hardness (MH) using nanoindentation testing, SL evaluation via scanning electron microscopy, and bond strength testing using a universal testing machine (UTM). Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test to determine the level of significance among the groups. A significant level of p<0.05 was established.
Results
Group 4 (CNPs+17 % EDTA) showed a high MH value of (0.25 ± 0.02 GPa), significantly outperforming Groups 1 (0.13 ± 0.02 GPa) and 3 (0.10 ± 0.03 GPa). Group 2 (Er: YAG laser + 17 % EDTA) demonstrated superior smear layer removal across all sections, particularly in the apical third (1.94 ± 0.38). Push-out bond strength was highest in Group 2 (9.98 ± 0.14 MPa at the cervical level) and Group 4 (10.08 ± 0.21 MPa), while Group 1 showed a decrease in apical bond strength of (5.11 ± 0.19 MPa)
Conclusion
CNPs and Er:YAG laser treatments, in comparison to Temoporfin and NaOCl, significantly increase dentin hardness and bond strength while reducing SL. This finding suggests that the incorporation of these innovative disinfection methods into endodontic procedures may enhance the durability and success of glass fiber post restorations.
{"title":"Efficacy of canal disinfectants Temoporfin, carbon nanoparticles, and Er: YAG laser on martens hardness, smear layer removal, and bond strength of glass fiber posts to canal dentin","authors":"Abdulaziz Alsahhaf","doi":"10.1016/j.pdpdt.2025.104490","DOIUrl":"10.1016/j.pdpdt.2025.104490","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the effectiveness of unconventional post space disinfection techniques, specifically Er:YAG laser, Temoporfin, and Carbon Nanoparticles (CNPs), in improving Martens hardness (MH), eliminating the smear layer (SL), and enhancing the push-out bond strength (PBS) of glass fiber posts in canal dentin.</div></div><div><h3>Methods</h3><div>An in vitro study was conducted utilizing 80 single-rooted extracted human teeth, which were decoronated and subjected to standardized root canal preparation. The teeth were equally distributed into four experimental groups: Group 1 (NaOCl + EDTA), Group 2 (Er: YAG laser + EDTA), Group 3 (Temoporfin + EDTA), and Group 4 (CNPs + EDTA). Each group underwent disinfection protocols followed by assessment of Martens hardness (MH) using nanoindentation testing, SL evaluation via scanning electron microscopy, and bond strength testing using a universal testing machine (UTM). Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test to determine the level of significance among the groups. A significant level of <em>p</em> <em><</em> <em>0.05</em> was established.</div></div><div><h3>Results</h3><div>Group 4 (CNPs+17 % EDTA) showed a high MH value of (0.25 ± 0.02 GPa), significantly outperforming Groups 1 (0.13 ± 0.02 GPa) and 3 (0.10 ± 0.03 GPa). Group 2 (Er: YAG laser + 17 % EDTA) demonstrated superior smear layer removal across all sections, particularly in the apical third (1.94 ± 0.38). Push-out bond strength was highest in Group 2 (9.98 ± 0.14 MPa at the cervical level) and Group 4 (10.08 ± 0.21 MPa), while Group 1 showed a decrease in apical bond strength of (5.11 ± 0.19 MPa)</div></div><div><h3>Conclusion</h3><div>CNPs and Er:YAG laser treatments, in comparison to Temoporfin and NaOCl, significantly increase dentin hardness and bond strength while reducing SL. This finding suggests that the incorporation of these innovative disinfection methods into endodontic procedures may enhance the durability and success of glass fiber post restorations.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104490"},"PeriodicalIF":3.1,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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