Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104849
Aleksandra Kawczyk-Krupka , Magdalena Krupka-Olek , Andrzej Bożek , Alicja Grzanka , Magdalena Czarnecka-Czapczyńska , Piotr Oleś , Grzegorz Cieślar , Małgorzata Kłósek , Zenon Czuba , Klaudia Dynarowicz , Dorota Bartusik-Aebisher , David Aebisher
Significance
The aim of the research was to determine the immunological profile of patients with selected inflammatory skin diseases (AD, PS) and the immunomodulatory effect of PDT conducted on skin cell lines.
Approach
A total of 139 patients with AD, 115 with PS, and 142 controls were included in the study. In this group the cytokines serum blood profiles was assessed. In vitro study was performed on the two human cell lines: HDFa and HEKa. Cell supernatants subjected to sublethal PDT were assessed to determine the interleukins concentrations using Bio-Plex system.
Results
Significant differences were observed in the concentration of assessed IL between patients with ADPS and those with AD or PS and controls The results of the in vitro study confirm the destructive and immunomodulatory effect of HY–PDT.
Conclusions
Our clinical study reveal differences of cytokines concentrations in AD, PS and ADPS patients. In vitro experiment has confirmed immunomodulatory effect of HY-PDT.
{"title":"The cytotoxic and immunomodulatory mechanisms of photodynamic therapy evaluated in in vitro studies on cultures of selected skin cell lines.”","authors":"Aleksandra Kawczyk-Krupka , Magdalena Krupka-Olek , Andrzej Bożek , Alicja Grzanka , Magdalena Czarnecka-Czapczyńska , Piotr Oleś , Grzegorz Cieślar , Małgorzata Kłósek , Zenon Czuba , Klaudia Dynarowicz , Dorota Bartusik-Aebisher , David Aebisher","doi":"10.1016/j.pdpdt.2025.104849","DOIUrl":"10.1016/j.pdpdt.2025.104849","url":null,"abstract":"<div><h3>Significance</h3><div>The aim of the research was to determine the immunological profile of patients with selected inflammatory skin diseases (AD, PS) and the immunomodulatory effect of PDT conducted on skin cell lines.</div></div><div><h3>Approach</h3><div>A total of 139 patients with AD, 115 with PS, and 142 controls were included in the study. In this group the cytokines serum blood profiles was assessed. <em>In vitro</em> study was performed on the two human cell lines: HDFa and HEKa. Cell supernatants subjected to sublethal PDT were assessed to determine the interleukins concentrations using Bio-Plex system.</div></div><div><h3>Results</h3><div>Significant differences were observed in the concentration of assessed IL between patients with ADPS and those with AD or PS and controls The results of the <em>in vitro</em> study confirm the destructive and immunomodulatory effect of HY–PDT.</div></div><div><h3>Conclusions</h3><div>Our clinical study reveal differences of cytokines concentrations in AD, PS and ADPS patients. <em>In vitro</em> experiment has confirmed immunomodulatory effect of HY-PDT.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104849"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104868
Ping Diao, H Chenhen, Xu Liu, Xian Jiang
Significance
This article shows that the therapy of 1064nm Nd: YAG laser combined with ALA-PDT in the treatment of giant phymatous rosacea has a good effect, and can be used as a supplementary treatment for refractory rosacea in clinical practice.
Approach
Physical examination found that the patient's nose had huge tissue hyperplasia, abundant sebaceous glands and thick blood vessels, with significant disfigurement. Taking into account the patient's age and poor basic condition, 1064nm Nd: YAG laser and ALA-PDT was planed in stages.
Results
After 3 sessions of 1064nm Nd:YAG laser and 3 sessions of ALA-PDT, the patient’ he patient's nose returned to normal shape basically, and the appearance was significantly improved.
Conclusions
1064nm Nd:YAG laser' cutting effect can reshape the shape of the nose, and the gasification and coagulation effect can reduce intraoperative bleeding. ALA-PDT can achieve the effect of atrophy of sebaceous glands and blood vessels.
{"title":"1064nm Nd: YAG laser combined with ALA-PDT for the treatment of a patient with giant phymatous rosacea","authors":"Ping Diao, H Chenhen, Xu Liu, Xian Jiang","doi":"10.1016/j.pdpdt.2025.104868","DOIUrl":"10.1016/j.pdpdt.2025.104868","url":null,"abstract":"<div><h3>Significance</h3><div>This article shows that the therapy of 1064nm Nd: YAG laser combined with ALA-PDT in the treatment of giant phymatous rosacea has a good effect, and can be used as a supplementary treatment for refractory rosacea in clinical practice.</div></div><div><h3>Approach</h3><div>Physical examination found that the patient's nose had huge tissue hyperplasia, abundant sebaceous glands and thick blood vessels, with significant disfigurement. Taking into account the patient's age and poor basic condition, 1064nm Nd: YAG laser and ALA-PDT was planed in stages.</div></div><div><h3>Results</h3><div>After 3 sessions of 1064nm Nd:YAG laser and 3 sessions of ALA-PDT, the patient’ he patient's nose returned to normal shape basically, and the appearance was significantly improved.</div></div><div><h3>Conclusions</h3><div>1064nm Nd:YAG laser' cutting effect can reshape the shape of the nose, and the gasification and coagulation effect can reduce intraoperative bleeding. ALA-PDT can achieve the effect of atrophy of sebaceous glands and blood vessels.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104868"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104886
Na Wang, Weiling He
The incidence and mortality rates of gastric cancer are high in our country, posing a significant threat to public health and imposing substantial economic burden and medical pressure. PDT (Photodynamic therapy) is still in the exploratory stage for treating gastric cancer. Although some progress has been made, demonstrating several irreplaceable advantages, there is still a need to improve its efficacy and study the specific mechanism of PDT-induced death in gastric cancer. PRKAA1 (protein kinase AMP-activated catalytic subunit α1), as a core factor in energy metabolism, plays a role in multiple biological processes involved in malignant tumor progression. This study aims to analyze the impact of PRKAA1 on PDT treatment for gastric cancer, explore the specific mechanism by which PDT promotes cell death through PRKAA1, and identify new targets and therapeutic strategies for treating this disease.
{"title":"Effect and Mechanism of Photodynamic Therapy on Pyroptosis of Gastric Cancer Cells via PRKAA1","authors":"Na Wang, Weiling He","doi":"10.1016/j.pdpdt.2025.104886","DOIUrl":"10.1016/j.pdpdt.2025.104886","url":null,"abstract":"<div><div>The incidence and mortality rates of gastric cancer are high in our country, posing a significant threat to public health and imposing substantial economic burden and medical pressure. PDT (Photodynamic therapy) is still in the exploratory stage for treating gastric cancer. Although some progress has been made, demonstrating several irreplaceable advantages, there is still a need to improve its efficacy and study the specific mechanism of PDT-induced death in gastric cancer. PRKAA1 (protein kinase AMP-activated catalytic subunit α1), as a core factor in energy metabolism, plays a role in multiple biological processes involved in malignant tumor progression. This study aims to analyze the impact of PRKAA1 on PDT treatment for gastric cancer, explore the specific mechanism by which PDT promotes cell death through PRKAA1, and identify new targets and therapeutic strategies for treating this disease.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104886"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104827
Nan Wang, Jiheng Zhang, Shaoshan Hu
Significance
Photodynamic therapy (PDT) is a promising adjunctive treatment for glioblastoma (GBM), but a comprehensive bibliometric analysis of this field has been lacking. This study provides an in-depth assessment of research trends, key contributors, and hotspots in PDT for GBM.
Approach
Bibliometric analysis of 799 documents from the Web of Science Core Collection 1993-2024 was conducted using CiteSpace software. Influential contributors and emerging research themes were identified through a 30 year analysis of publication trends, collaborative networks and keyword co-occurrence.
Results
Publications peaked in 2022, with the United States and China as leading contributors. Notable institutions included the University of California System and Centre National de la Recherche Scientifique. Research has progressed from photodynamic diagnostics to innovative strategies like nanotechnology and combination therapies, addressing tumor heterogeneity and drug resistance.
Conclusions
This study emphasizes the need for robust interdisciplinary research and clinical translation to enhance its therapeutic potential.
光动力疗法（PDT）是一种很有前景的胶质母细胞瘤（GBM）辅助治疗方法，但目前还缺乏对该领域的全面文献计量学分析。本研究对PDT治疗GBM的研究趋势、主要贡献者和热点进行了深入的评估。方法利用CiteSpace软件对Web of Science Core Collection 1993-2024年的799篇文献进行文献计量学分析。通过对出版趋势、合作网络和关键词共现的30年分析，确定了有影响力的贡献者和新兴的研究主题。论文发表量在2022年达到顶峰，美国和中国是主要贡献者。著名的机构包括加州大学系统和国家科学研究中心。研究已经从光动力学诊断发展到创新策略，如纳米技术和联合治疗，解决肿瘤异质性和耐药性。结论本研究强调了加强跨学科研究和临床转化以增强其治疗潜力的必要性。
{"title":"Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric Analysis","authors":"Nan Wang, Jiheng Zhang, Shaoshan Hu","doi":"10.1016/j.pdpdt.2025.104827","DOIUrl":"10.1016/j.pdpdt.2025.104827","url":null,"abstract":"<div><h3>Significance</h3><div>Photodynamic therapy (PDT) is a promising adjunctive treatment for glioblastoma (GBM), but a comprehensive bibliometric analysis of this field has been lacking. This study provides an in-depth assessment of research trends, key contributors, and hotspots in PDT for GBM.</div></div><div><h3>Approach</h3><div>Bibliometric analysis of 799 documents from the Web of Science Core Collection 1993-2024 was conducted using CiteSpace software. Influential contributors and emerging research themes were identified through a 30 year analysis of publication trends, collaborative networks and keyword co-occurrence.</div></div><div><h3>Results</h3><div>Publications peaked in 2022, with the United States and China as leading contributors. Notable institutions included the University of California System and Centre National de la Recherche Scientifique. Research has progressed from photodynamic diagnostics to innovative strategies like nanotechnology and combination therapies, addressing tumor heterogeneity and drug resistance.</div></div><div><h3>Conclusions</h3><div>This study emphasizes the need for robust interdisciplinary research and clinical translation to enhance its therapeutic potential.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104827"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104859
Kun Yang
To assess the effectiveness of moist burn ointment in wound care following CO2 fractional laser treatment for superficial scars. The study involved 60 patients (randomly divided into two groups, each with 30 participants) treated at Shanghai Tongji University Stomatology Hospital from January 2023 to August 2024. The control group received dry wound care, while the test group was treated with moist burn ointment. Wound healing time, pain levels, scar improvement, adverse reactions, and nursing satisfaction were evaluated. The test group showed significantly shorter wound healing times, lower Visual Scar Scale (VSS) and Visual Analog Scale (VAS) scores, higher scar improvement rates (96.67% vs. 80.00%), fewer adverse reactions (6.67% vs. 30.00%), and greater nursing satisfaction (93.33% vs. 73.33%) compared to the control group (P<0.05). Moist burn ointment enhances wound healing, reduces scarring, alleviates pain, and improves patient satisfaction after CO2 laser treatment, making it a promising clinical option.
{"title":"Moist Burn Ointment in Wound Care after CO2 Fractional Laser Treatment for Superficial Scars","authors":"Kun Yang","doi":"10.1016/j.pdpdt.2025.104859","DOIUrl":"10.1016/j.pdpdt.2025.104859","url":null,"abstract":"<div><div>To assess the effectiveness of moist burn ointment in wound care following CO2 fractional laser treatment for superficial scars. The study involved 60 patients (randomly divided into two groups, each with 30 participants) treated at Shanghai Tongji University Stomatology Hospital from January 2023 to August 2024. The control group received dry wound care, while the test group was treated with moist burn ointment. Wound healing time, pain levels, scar improvement, adverse reactions, and nursing satisfaction were evaluated. The test group showed significantly shorter wound healing times, lower Visual Scar Scale (VSS) and Visual Analog Scale (VAS) scores, higher scar improvement rates (96.67% vs. 80.00%), fewer adverse reactions (6.67% vs. 30.00%), and greater nursing satisfaction (93.33% vs. 73.33%) compared to the control group (P<0.05). Moist burn ointment enhances wound healing, reduces scarring, alleviates pain, and improves patient satisfaction after CO2 laser treatment, making it a promising clinical option.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104859"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isotope treatment of port wine stains (PWS) may lead to skin damage and cancer. And Hemoporfin-PDT may be a potential treatment option for isotope-resistant PWS.
Approach
Six PWS patients, previously treated unsuccessfully with isotopes, enrolled in this study. After obtaining informed consent, they underwent mutiple Hemoporfin-PDT at our center. Baseline and 3-month post-treatment images were captured using high-definition photography, with additional imaging techniques (dermoscopy, high-frequency ultrasound, and VISIA photography) employed when possible.
Results
Hemoporfin-PDT successfully treated six PWS patients with suboptimal isotope therapy outcomes, alleviating significant physical and psychological distress. The treatment was well-tolerated, reducing lesion severity by at least 50% after 2-4 sessions with minimal side effects.
Conclusions
Hemoporfin-PDT may offer a safe and effective treatment option for patients with isotope-resistant port-wine stains who have experienced treatment failure and irreversible skin damage from previous modalities, such as isotope therapy.
{"title":"Efficacy of Hemoporfin-PDT in Treating Isotope-Resistant Port-Wine Stains: A Case Series","authors":"Chunzhi Qi, Jing Liu, Yawen Wang, Die Hu, Zhao Wang, Songmei Geng, Weihui Zeng","doi":"10.1016/j.pdpdt.2025.104806","DOIUrl":"10.1016/j.pdpdt.2025.104806","url":null,"abstract":"<div><h3>Significance</h3><div>Isotope treatment of port wine stains (PWS) may lead to skin damage and cancer. And Hemoporfin-PDT may be a potential treatment option for isotope-resistant PWS.</div></div><div><h3>Approach</h3><div>Six PWS patients, previously treated unsuccessfully with isotopes, enrolled in this study. After obtaining informed consent, they underwent mutiple Hemoporfin-PDT at our center. Baseline and 3-month post-treatment images were captured using high-definition photography, with additional imaging techniques (dermoscopy, high-frequency ultrasound, and VISIA photography) employed when possible.</div></div><div><h3>Results</h3><div>Hemoporfin-PDT successfully treated six PWS patients with suboptimal isotope therapy outcomes, alleviating significant physical and psychological distress. The treatment was well-tolerated, reducing lesion severity by at least 50% after 2-4 sessions with minimal side effects.</div></div><div><h3>Conclusions</h3><div>Hemoporfin-PDT may offer a safe and effective treatment option for patients with isotope-resistant port-wine stains who have experienced treatment failure and irreversible skin damage from previous modalities, such as isotope therapy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104806"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104831
Xiuwei Yan, Shaoshan Hu
Objective
Explore the effects of DHA combined with PDT on ferroptosis and ROS production in glioma cells.
Methods
The activity of tumor cells was detected by MTT assay. The invasion and proliferation ability of tumor cells were detected by scratch and transwell. ROS production was detected by confocal microscopy and flow cytometry. In vitro and in vivo experiments were conducted to verify the effect of the screening pathway on ferroptosis and ROS production in glioma.
Results
In vivo and in vitro experiments showed that combined therapy could produce a significant inhibitory effect on glioma. Through bioinformatics analysis, Nrf2 was selected as a gene related to ferroptosis for further study. DHA combined with PDT can induce ferroptosis and ROS production by inhibiting the Nrf2-Keap1 pathway.
Conclusion
DHA combined with PDT can induce ferroptosis and ROS production in glioma by inhibiting the Nrf2-Keap1 pathway, and inhibiting the invasion and proliferation of glioma.
{"title":"DHA induces ferroptosis to enhance the efficacy of the photodynamic treatment of glioma through inhibits the Nrf2-Keap1 pathway","authors":"Xiuwei Yan, Shaoshan Hu","doi":"10.1016/j.pdpdt.2025.104831","DOIUrl":"10.1016/j.pdpdt.2025.104831","url":null,"abstract":"<div><h3>Objective</h3><div>Explore the effects of DHA combined with PDT on ferroptosis and ROS production in glioma cells.</div></div><div><h3>Methods</h3><div>The activity of tumor cells was detected by MTT assay. The invasion and proliferation ability of tumor cells were detected by scratch and transwell. ROS production was detected by confocal microscopy and flow cytometry. In vitro and in vivo experiments were conducted to verify the effect of the screening pathway on ferroptosis and ROS production in glioma.</div></div><div><h3>Results</h3><div>In vivo and in vitro experiments showed that combined therapy could produce a significant inhibitory effect on glioma. Through bioinformatics analysis, Nrf2 was selected as a gene related to ferroptosis for further study. DHA combined with PDT can induce ferroptosis and ROS production by inhibiting the Nrf2-Keap1 pathway.</div></div><div><h3>Conclusion</h3><div>DHA combined with PDT can induce ferroptosis and ROS production in glioma by inhibiting the Nrf2-Keap1 pathway, and inhibiting the invasion and proliferation of glioma.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104831"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104837
Shanshan Li , Minzhi Wu , Yun Wu , Linlin Wu , Hongwei Wang , Xiuli Wang , Jingjing Li
Objective
To summarize the clinical efficacy and safety of Intense Pulsed Light Photodynamic Therapy (IPL-PDT) in the treatment of refractory rosacea.
Methods
Patients with refractory rosacea presenting with erythema, papules and pustules accompanied by discomfort such as burning and pruritus treated with IPL-PDT using ALA (aminolevulinic acid) in our department and the institute of photomedicine of Shanghai Skin Disease Hospital from April 2024 to April 2025 were collected. The clinical efficacy and safety were retrospectively analyzed.
Results
30 female patients with refractory rosacea were included, with an age of (33±4.8) years. All of them were treated with three to five sessions of IPL-PDT. After the treatment, the facial skin lesions improved significantly. The pruritus was significantly relieved after the second session of IPL-PDT, and the erythema significantly subsided and the papules decreased after the treatment of PDT. The red areas detected by VISIA skin analyzer were significantly improved compared with those before treatment, and the difference was statistically significant (P<0.05). The patients were all satisfied with the improvement of facial skin lesions. After the treatment, the patient suffered from transient adverse reactions such as erythema papules, mild edema, dryness and pruritus, which could subside within one week.
Conclusion
IPL-PDT shows excellent clinical efficacy in the treatment of rosacea, with mild adverse reactions and high patients’ satisfaction. It can be considered as one of the treatment options for refractory rosacea.
{"title":"Intense Pulsed Light Photodynamic Therapy (IPL-PDT) successfully treated Refractory Rosacea: A retrospective case series","authors":"Shanshan Li , Minzhi Wu , Yun Wu , Linlin Wu , Hongwei Wang , Xiuli Wang , Jingjing Li","doi":"10.1016/j.pdpdt.2025.104837","DOIUrl":"10.1016/j.pdpdt.2025.104837","url":null,"abstract":"<div><h3>Objective</h3><div>To summarize the clinical efficacy and safety of Intense Pulsed Light Photodynamic Therapy (IPL-PDT) in the treatment of refractory rosacea.</div></div><div><h3>Methods</h3><div>Patients with refractory rosacea presenting with erythema, papules and pustules accompanied by discomfort such as burning and pruritus treated with IPL-PDT using ALA (aminolevulinic acid) in our department and the institute of photomedicine of Shanghai Skin Disease Hospital from April 2024 to April 2025 were collected. The clinical efficacy and safety were retrospectively analyzed.</div></div><div><h3>Results</h3><div>30 female patients with refractory rosacea were included, with an age of (33±4.8) years. All of them were treated with three to five sessions of IPL-PDT. After the treatment, the facial skin lesions improved significantly. The pruritus was significantly relieved after the second session of IPL-PDT, and the erythema significantly subsided and the papules decreased after the treatment of PDT. The red areas detected by VISIA skin analyzer were significantly improved compared with those before treatment, and the difference was statistically significant (P<0.05). The patients were all satisfied with the improvement of facial skin lesions. After the treatment, the patient suffered from transient adverse reactions such as erythema papules, mild edema, dryness and pruritus, which could subside within one week.</div></div><div><h3>Conclusion</h3><div>IPL-PDT shows excellent clinical efficacy in the treatment of rosacea, with mild adverse reactions and high patients’ satisfaction. It can be considered as one of the treatment options for refractory rosacea.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104837"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104813
Yawen Wang , Jing Liu , Jun Xia , Youbao Li , Rongrui Zhang , Songmei Geng , Weihui Zeng
Significance
Although PDL is traditional therapy for PWS, it has limitation of relatively low treatment rate. Hemoporfin-PDT, which has satisfactory efficacy, can only be used in patients over 1-year-old. In view of early treatment could result in greater effectiveness, we confirmed the safety and efficacy of sequential therapy with PDL before one year old and Hemoporfin-PDT after one year old for treating PWS.
Approach
The lesions of two 6-month-old children were categorized into the Sequential side and the Hemoporfin-PDT side.
Results
Efficacy of PDL combined with Hemoporfin-PDT sequential therapy is superior to merely Hemoporfin-PDT for treating PWS. The Sequential side were nearly completely resolved, while the Hemoporfin-PDT side only partially reduced. No significant differences in adverse effects between two sides.
Conclusions
PDL before one year old combined with subsequent Hemoporfin-PDT sequential therapy is a safe treatment strategy on PWS, which is more effective than merely Hemoporfin-PDT after one year old.
{"title":"The Safety and Efficacy of PDL Combined with Hemoporfin-PDT Sequential Therapy for Treating PWS: Two Case Reports","authors":"Yawen Wang , Jing Liu , Jun Xia , Youbao Li , Rongrui Zhang , Songmei Geng , Weihui Zeng","doi":"10.1016/j.pdpdt.2025.104813","DOIUrl":"10.1016/j.pdpdt.2025.104813","url":null,"abstract":"<div><h3>Significance</h3><div>Although PDL is traditional therapy for PWS, it has limitation of relatively low treatment rate. Hemoporfin-PDT, which has satisfactory efficacy, can only be used in patients over 1-year-old. In view of early treatment could result in greater effectiveness, we confirmed the safety and efficacy of sequential therapy with PDL before one year old and Hemoporfin-PDT after one year old for treating PWS.</div></div><div><h3>Approach</h3><div>The lesions of two 6-month-old children were categorized into the Sequential side and the Hemoporfin-PDT side.</div></div><div><h3>Results</h3><div>Efficacy of PDL combined with Hemoporfin-PDT sequential therapy is superior to merely Hemoporfin-PDT for treating PWS. The Sequential side were nearly completely resolved, while the Hemoporfin-PDT side only partially reduced. No significant differences in adverse effects between two sides.</div></div><div><h3>Conclusions</h3><div>PDL before one year old combined with subsequent Hemoporfin-PDT sequential therapy is a safe treatment strategy on PWS, which is more effective than merely Hemoporfin-PDT after one year old.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104813"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.pdpdt.2025.104818
Lan Chen , Kai Chen
Significance
To assess the association between PDT and dermatitis, and the mechanism of PDT-triggered dermatitis in PWS patients.
Approach
Clinical images were used to calculate the percentage of dermatitis. The arithmetic mean roughness (Ra), the average depth of roughness (Rz) and the mean square roughness (Rq) were used to assess the change of surface roughness. Transepidermal water loss (TEWL), stratum corneum hydration (SCH) and total lipid content (TLC) were used to analyze the skin barrier function.
Results
After treatment, we found that the percentage of dermatitis was closely related to the treatment times and age. Moreover, the skin surface roughness of Ra, Rz, Rq and the skin barrier function of TEWL and TLC of these treated areas all were increased (p<0.05), and the SCH was decreased (p<0.05).
Conclusions
PDT caused skin barrier damage in treated area, which may lead to increased epidermal permeability and trigger dermatitis in PWS patients.
{"title":"Hemoporfin-mediated photodynamic therapy-caused skin barrier damage and triggered dermatitis in Port-Wine Stains","authors":"Lan Chen , Kai Chen","doi":"10.1016/j.pdpdt.2025.104818","DOIUrl":"10.1016/j.pdpdt.2025.104818","url":null,"abstract":"<div><h3>Significance</h3><div>To assess the association between PDT and dermatitis, and the mechanism of PDT-triggered dermatitis in PWS patients.</div></div><div><h3>Approach</h3><div>Clinical images were used to calculate the percentage of dermatitis. The arithmetic mean roughness (Ra), the average depth of roughness (Rz) and the mean square roughness (Rq) were used to assess the change of surface roughness. Transepidermal water loss (TEWL), stratum corneum hydration (SCH) and total lipid content (TLC) were used to analyze the skin barrier function.</div></div><div><h3>Results</h3><div>After treatment, we found that the percentage of dermatitis was closely related to the treatment times and age. Moreover, the skin surface roughness of Ra, Rz, Rq and the skin barrier function of TEWL and TLC of these treated areas all were increased (p<0.05), and the SCH was decreased (p<0.05).</div></div><div><h3>Conclusions</h3><div>PDT caused skin barrier damage in treated area, which may lead to increased epidermal permeability and trigger dermatitis in PWS patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104818"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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