Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104466
Lulu Wang , Yahui Feng , Sisi Wang , Leyao Shi , Yong Ren , Zhiya Yang , Dongmei Shi
Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agents to successfully treat Candida infection. We present a case of cutaneous mass caused by Candida albicans (C.albicans) treated solely with 5-aminolevulinic acid (ALA)- PDT. A 21-year-old female presented with a cutaneous lesion on her right elbow,. characterized by erythema, nodules, and cysts that had persisted for 3 months after surgical excision. The diagnosis of infectious granulomas caused by C. albicans was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. During the 6-month follow-up, there were no signs of relapse. This case suggested that mono-ALA-PDT can be an effective treatment option for single lesion on the body surface caused by C. albicans deep infection.
{"title":"Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report","authors":"Lulu Wang , Yahui Feng , Sisi Wang , Leyao Shi , Yong Ren , Zhiya Yang , Dongmei Shi","doi":"10.1016/j.pdpdt.2024.104466","DOIUrl":"10.1016/j.pdpdt.2024.104466","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agents to successfully treat <em>Candida</em> infection. We present a case of cutaneous mass caused by <em>Candida albicans</em> (<em>C.albicans</em>) treated solely with 5-aminolevulinic acid (ALA)- PDT. A 21-year-old female presented with a cutaneous lesion on her right elbow,. characterized by erythema, nodules, and cysts that had persisted for 3 months after surgical excision. The diagnosis of infectious granulomas caused by <em>C. albicans</em> was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. During the 6-month follow-up, there were no signs of relapse. This case suggested that mono-ALA-PDT can be an effective treatment option for single lesion on the body surface caused by <em>C. albicans</em> deep infection.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104466"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2025.104479
Maria Zaharieva Mutafchieva , Milena Nenkova Draganova , Plamen Ivanov Zagorchev , Reem Hanna , Georgi Tomchev Tomov
Purpose
Oral lichen planus (OLP) is a chronic inflammatory disease, in which T-Lymphocytes induce apoptosis of basal keratinocytes, leading to the formation of symptomatic lesions. It is assumed that blocking the cell death program and enhancing cell proliferation would be crucial to the healing process. The aim of the study was to verify the efficacy of Photobiomodulation (PBM) in OLP management, by evaluating the effects of laser irradiation on the processes of apoptosis and cell proliferation.
Methods
Twenty patients with OLP underwent PBM with 810 nm diode laser (0.5 W, 30 s, 1.2 J/cm2), 3 times a week for one month. The size and clinical scores of the lesions and pain level were recorded and compared before and after therapy using Thongprasom sign scoring system and Visual Analogue Scale, respectively. Biopsies were taken before and after therapy and analyzed immunohistochemically for bcl-2 and Ki-67 expression. Tissue sections from 10 healthy volunteers were used as controls for the levels of these markers in normal oral mucosa.
Results
PBM significantly reduced patients’ pain intesity and improved the clinical signs of the lesions. OLP tissue sections demonstrated lower staining for bcl-2 and Ki-67 compared to healthy controls. After therapy the expression of bcl-2 increased significantly. An enhance in Ki-67 immunoreactivity was revealed predominantly in the atrophic-erosive epithelium.
Conclusion
PBM is an effective treatment modality for OLP patients. Erosive forms of the disease responded better to laser irradiation than keratotic subtypes. At the molecular level, PBM is likely to recover the impaired cell cycle mechanisms and keratinocyte proliferation.
{"title":"Molecular evidence for the efficacy of PBM therapy in the treatment of oral lichen planus","authors":"Maria Zaharieva Mutafchieva , Milena Nenkova Draganova , Plamen Ivanov Zagorchev , Reem Hanna , Georgi Tomchev Tomov","doi":"10.1016/j.pdpdt.2025.104479","DOIUrl":"10.1016/j.pdpdt.2025.104479","url":null,"abstract":"<div><h3>Purpose</h3><div>Oral lichen planus (OLP) is a chronic inflammatory disease, in which T-Lymphocytes induce apoptosis of basal keratinocytes, leading to the formation of symptomatic lesions. It is assumed that blocking the cell death program and enhancing cell proliferation would be crucial to the healing process. The aim of the study was to verify the efficacy of Photobiomodulation (PBM) in OLP management, by evaluating the effects of laser irradiation on the processes of apoptosis and cell proliferation.</div></div><div><h3>Methods</h3><div>Twenty patients with OLP underwent PBM with 810 nm diode laser (0.5 W, 30 s, 1.2 J/cm<sup>2</sup>), 3 times a week for one month. The size and clinical scores of the lesions and pain level were recorded and compared before and after therapy using Thongprasom sign scoring system and Visual Analogue Scale, respectively. Biopsies were taken before and after therapy and analyzed immunohistochemically for bcl-2 and Ki-67 expression. Tissue sections from 10 healthy volunteers were used as controls for the levels of these markers in normal oral mucosa.</div></div><div><h3>Results</h3><div>PBM significantly reduced patients’ pain intesity and improved the clinical signs of the lesions. OLP tissue sections demonstrated lower staining for bcl-2 and Ki-67 compared to healthy controls. After therapy the expression of bcl-2 increased significantly. An enhance in Ki-67 immunoreactivity was revealed predominantly in the atrophic-erosive epithelium.</div></div><div><h3>Conclusion</h3><div>PBM is an effective treatment modality for OLP patients. Erosive forms of the disease responded better to laser irradiation than keratotic subtypes. At the molecular level, PBM is likely to recover the impaired cell cycle mechanisms and keratinocyte proliferation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104479"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104435
Rongrong Guan , Shuyan Qin , Yezhu Chi , Zhen Tang , Haiyang Liu
Objective
To study the changes in retinal and choroidal vessels in patients with coronary artery stenosis via optical coherence tomography angiography (OCTA).
Methods
A total of 100 subjects were enrolled in this study and divided into two groups: the observation group consisted of 50 patients with angina who were first diagnosed with coronary artery stenosis, and the control group consisted of 50 healthy adults without angina symptoms. All of the subjects underwent OCTA to investigate changes in retinochoroidal vessel density in patients with a first diagnosis of coronary artery stenosis. The parameters included superficial capillary plexus density (SCD), deep capillary plexus density (DCD), retinal peripapillary capillary plexus density(RPD), the choroidal vascular index (CVI), and the macular foveal avascular zone(FAZ area, perimeter, acircularity index, FD-300 vessel density).
Results
SCD and DCD in the coronary artery stenosis group were lower than those in the control group (P = 0.045 and P = 0.034, respectively), the CVI was lower than that in the control group (P = 0.029), the FAZ perimeter and acircularity index were greater than those in the control group (P = 0.003,P = 0.024). Logistic regression and ROC curve analysis revealed that FAZ perimeter was the most significant risk factor for predicting coronary artery stenosis (P = 0.005, AUC = 0.664), and the cut-off value for FAZ perimeter was 2.065 mm.
Conclusions
In patients with a first diagnosis of coronary artery stenosis, both retinal and choroidal blood flow are reduced. FAZ perimeter is a risk factor for predicting the occurrence of coronary artery stenosis.
{"title":"Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis","authors":"Rongrong Guan , Shuyan Qin , Yezhu Chi , Zhen Tang , Haiyang Liu","doi":"10.1016/j.pdpdt.2024.104435","DOIUrl":"10.1016/j.pdpdt.2024.104435","url":null,"abstract":"<div><h3>Objective</h3><div>To study the changes in retinal and choroidal vessels in patients with coronary artery stenosis via optical coherence tomography angiography (OCTA).</div></div><div><h3>Methods</h3><div>A total of 100 subjects were enrolled in this study and divided into two groups: the observation group consisted of 50 patients with angina who were first diagnosed with coronary artery stenosis, and the control group consisted of 50 healthy adults without angina symptoms. All of the subjects underwent OCTA to investigate changes in retinochoroidal vessel density in patients with a first diagnosis of coronary artery stenosis. The parameters included superficial capillary plexus density (SCD), deep capillary plexus density (DCD), retinal peripapillary capillary plexus density(RPD), the choroidal vascular index (CVI), and the macular foveal avascular zone(FAZ area, perimeter, acircularity index, FD-300 vessel density).</div></div><div><h3>Results</h3><div>SCD and DCD in the coronary artery stenosis group were lower than those in the control group (<em>P</em> = 0.045 and <em>P</em> = 0.034, respectively), the CVI was lower than that in the control group (<em>P</em> = 0.029), the FAZ perimeter and acircularity index were greater than those in the control group (<em>P</em> = 0.003,<em>P</em> = 0.024). Logistic regression and ROC curve analysis revealed that FAZ perimeter was the most significant risk factor for predicting coronary artery stenosis (<em>P</em> = 0.005, AUC = 0.664), and the cut-off value for FAZ perimeter was 2.065 mm.</div></div><div><h3>Conclusions</h3><div>In patients with a first diagnosis of coronary artery stenosis, both retinal and choroidal blood flow are reduced. FAZ perimeter is a risk factor for predicting the occurrence of coronary artery stenosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104435"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104448
Rong Luan, Jinzhi Zhao, Zeying Liu, Limin Zhu, Lingyao Kong, Xiaorong Li, Tingting Lin
We report a rare case of Saturday Night Retinopathy (SNR) following postoperative orbital compression bandaging, highlighting the value of multimodal imaging in diagnosis and management. A 24-year-old male underwent surgical repair of an inferior orbital wall fracture with an absorbable implant, followed by compression bandaging of the right eye for three days. Upon bandage removal, the patient experienced a significant drop in visual acuity (VA) from 20/20 to 20/200. Multimodal imaging, including diagnostic imaging and angiography, revealed retinal and choroidal ischemia without optic nerve compression, confirming the diagnosis of SNR. The patient received intravenous corticosteroids, which led to a gradual recovery of VA to 20/20 over several weeks. This case underscores the critical role of multimodal imaging in identifying ischemic changes and guiding timely treatment. It also highlights the risk of ischemic complications from postoperative bandaging. To our knowledge, this is the first case of SNR due to compression bandaging, emphasizing the need for cautious postoperative care and the utility of advanced imaging techniques in ophthalmology.
{"title":"A case of Saturday night retinopathy following postoperative orbital compression bandaging: Diagnosis and evaluation using multimodal imaging","authors":"Rong Luan, Jinzhi Zhao, Zeying Liu, Limin Zhu, Lingyao Kong, Xiaorong Li, Tingting Lin","doi":"10.1016/j.pdpdt.2024.104448","DOIUrl":"10.1016/j.pdpdt.2024.104448","url":null,"abstract":"<div><div>We report a rare case of Saturday Night Retinopathy (SNR) following postoperative orbital compression bandaging, highlighting the value of multimodal imaging in diagnosis and management. A 24-year-old male underwent surgical repair of an inferior orbital wall fracture with an absorbable implant, followed by compression bandaging of the right eye for three days. Upon bandage removal, the patient experienced a significant drop in visual acuity (VA) from 20/20 to 20/200. Multimodal imaging, including diagnostic imaging and angiography, revealed retinal and choroidal ischemia without optic nerve compression, confirming the diagnosis of SNR. The patient received intravenous corticosteroids, which led to a gradual recovery of VA to 20/20 over several weeks. This case underscores the critical role of multimodal imaging in identifying ischemic changes and guiding timely treatment. It also highlights the risk of ischemic complications from postoperative bandaging. To our knowledge, this is the first case of SNR due to compression bandaging, emphasizing the need for cautious postoperative care and the utility of advanced imaging techniques in ophthalmology.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104448"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104414
Xiaohan Liu , Yang Tan , Qionghui Cheng , Liang Wang , Jinyi Chen , Hong Liu , Wen Ding , Xia Lei
Background
Effective management of cutaneous nocardiosis is hampered by the lack of defined treatment recommendations and frequently requires prolonged antibiotic therapy.
Case presentation
This report describes a case of cutaneous nocardiosis who was effectively treated in a brief amount of time with three sessions of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in conjunction with antibiotics.
Conclusion
ALA-PDT combined with antibiotics may effectively treat refractory cutaneous nocardiosis.
{"title":"Combination treatment with photodynamic therapy and antibiotic in refractory cutaneous nocardiosis: A case report","authors":"Xiaohan Liu , Yang Tan , Qionghui Cheng , Liang Wang , Jinyi Chen , Hong Liu , Wen Ding , Xia Lei","doi":"10.1016/j.pdpdt.2024.104414","DOIUrl":"10.1016/j.pdpdt.2024.104414","url":null,"abstract":"<div><h3>Background</h3><div>Effective management of cutaneous nocardiosis is hampered by the lack of defined treatment recommendations and frequently requires prolonged antibiotic therapy.</div></div><div><h3>Case presentation</h3><div>This report describes a case of cutaneous nocardiosis who was effectively treated in a brief amount of time with three sessions of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in conjunction with antibiotics.</div></div><div><h3>Conclusion</h3><div>ALA-PDT combined with antibiotics may effectively treat refractory cutaneous nocardiosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104414"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Photodynamic diagnosis-assisted transurethral resection of bladder tumor (PDD-TURBT) is an important and useful intervention used for removing non-invasive bladder cancer (NMIBC). Several PDD devices can be used in clinical practice, but few reports have compared them.In this study, we examined the differences in detected fluorescence intensity for each PDD device.
Methods
The PDD device was used from OLYMPUS, Richard Wolf, and Karl Storz. Light power and illuminance from endoscope were measured. For each PDD device, fluorescence intensity was measured at 3 cm and 8 cm distance from the protoporphyrin IX (PpIX) phantom to the cystoscope.
Results
The variation of excitation light power with observation distance were 35.0 %, 27.0 %, and 28.2 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively. The variation of fluorescence intensity with observation distance were 132.8 %, 120.5 %, and 49.8 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively.
Conclusions
PDD devices used in clinical practice show both some performance differences between the PDD systems themselves, and also differences in observed fluorescence intensity.
{"title":"Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems","authors":"Hideo Fukuhara , Takahiro Nishimura , Yu Shimojo , Keiji Inoue","doi":"10.1016/j.pdpdt.2024.104425","DOIUrl":"10.1016/j.pdpdt.2024.104425","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic diagnosis-assisted transurethral resection of bladder tumor (PDD-TURBT) is an important and useful intervention used for removing non-invasive bladder cancer (NMIBC). Several PDD devices can be used in clinical practice, but few reports have compared them.In this study, we examined the differences in detected fluorescence intensity for each PDD device.</div></div><div><h3>Methods</h3><div>The PDD device was used from OLYMPUS, Richard Wolf, and Karl Storz. Light power and illuminance from endoscope were measured. For each PDD device, fluorescence intensity was measured at 3 cm and 8 cm distance from the protoporphyrin IX (PpIX) phantom to the cystoscope.</div></div><div><h3>Results</h3><div>The variation of excitation light power with observation distance were 35.0 %, 27.0 %, and 28.2 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively. The variation of fluorescence intensity with observation distance were 132.8 %, 120.5 %, and 49.8 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively.</div></div><div><h3>Conclusions</h3><div>PDD devices used in clinical practice show both some performance differences between the PDD systems themselves, and also differences in observed fluorescence intensity.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104425"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104441
Juan Felipe Ramirez Giraldo, Jorge Enrique Gomez Marin
Protozoa present in water for human consumption represent a significant public health risk to a greater extent in the most vulnerable populations. Identifying protozoa in a traditional way through microscopy or with more advanced technologies such as molecular biology may present limitations in sensitivity, specificity, time, and costs. Fourier Transform Infrared (FTIR) spectroscopy have potential as an alternative for the detection of protozoa in water used for human consumption. An exhaustive search was carried out in the databases, SCIELO, PubMed, SCOPUS and Google Scholar, with the search terms “protozoa,” “protozoan,” “parasite,” “FTIR,” “infrared spectroscopy.” Only six articles met the inclusion criteria. FTIR spectroscopy can detect changes in biochemical composition but has not been used for the identification of parasites in human clinical or environmental samples. The present systematic review identified a lack of studies in this area and the need to conduct research aimed at developing standardized methods and creating spectral database banks of protozoan species that will allow for the precise identification of protozoa such as Cryptosporidium spp. and Giardia spp. in water for human consumption.
人类饮用水中的原生动物对公共健康构成重大威胁，对最脆弱人群的影响更大。通过显微镜等传统方法或分子生物学等更先进的技术来识别原生动物，可能会在灵敏度、特异性、时间和成本等方面受到限制。傅立叶变换红外（FTIR）光谱法有可能成为检测人类饮用水中原生动物的替代方法。我们在 SCIELO、PubMed、SCOPUS 和 Google Scholar 等数据库中以 "原生动物"、"原生动物"、"寄生虫"、"傅立叶变换红外光谱"、"红外光谱 "为检索词进行了详尽的搜索。只有六篇文章符合纳入标准。傅立叶红外光谱法可检测生化成分的变化，但尚未用于人类临床或环境样本中寄生虫的鉴定。本系统综述发现该领域缺乏研究，因此有必要开展研究，以开发标准化方法，建立原生动物物种光谱数据库，从而精确鉴定人类饮用水中的隐孢子虫属和贾第鞭毛虫属等原生动物。
{"title":"Application of Fourier transform infrared spectroscopy (FTIR) for protozoan analysis: A systematic review","authors":"Juan Felipe Ramirez Giraldo, Jorge Enrique Gomez Marin","doi":"10.1016/j.pdpdt.2024.104441","DOIUrl":"10.1016/j.pdpdt.2024.104441","url":null,"abstract":"<div><div>Protozoa present in water for human consumption represent a significant public health risk to a greater extent in the most vulnerable populations. Identifying protozoa in a traditional way through microscopy or with more advanced technologies such as molecular biology may present limitations in sensitivity, specificity, time, and costs. Fourier Transform Infrared (FTIR) spectroscopy have potential as an alternative for the detection of protozoa in water used for human consumption. An exhaustive search was carried out in the databases, SCIELO, PubMed, SCOPUS and Google Scholar, with the search terms “protozoa,” “protozoan,” “parasite,” “FTIR,” “infrared spectroscopy.” Only six articles met the inclusion criteria. FTIR spectroscopy can detect changes in biochemical composition but has not been used for the identification of parasites in human clinical or environmental samples. The present systematic review identified a lack of studies in this area and the need to conduct research aimed at developing standardized methods and creating spectral database banks of protozoan species that will allow for the precise identification of protozoa such as <em>Cryptosporidium spp</em>. and <em>Giardia spp.</em> in water for human consumption.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104441"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104446
Chunwei Xu, Xinhua Cui, Jiafei Che, Xiaojing Shen, Dingchao Chen
Objective
This study aimed to evaluate the effectiveness and safety of fluorescence navigation combined with three-dimensional imaging (FN&3DI) technology in precise liver resection.
Methods
A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for all English-language publications on fluorescence-guided navigation combined with three-dimensional (3D) imaging technology–assisted precise liver resection, with a cutoff date of July 2024. After assessing the quality of the included studies and extracting relevant data, a meta-analysis was performed using Stata 12.0 software.
Results
A total of 6 studies involving 451 patients were included in this study, with 207 patients in the FN&3DI group and 244 patients in the conventional surgery (CS) group. The meta-analysis results showed that the FN&3DI group exhibited significantly lower values than the CS group in terms of intraoperative blood loss [mean difference (MD) = –97.90, 95 % confidence intervals (CI) = –151.15 to –44.66, P = 0.000], intraoperative blood transfusion rates [odds ratios (OR) = 2.96, 95 % CI = 1.71–5.10, P = 0.000], hospital stay (MD = –0.91, 95 % CI = –1.78 to –0.04, P = 0.041), and overall postoperative complications (OR = 1.68, 95 % CI = 1.11 to 2.53, P = 0.014). However, the FN&3DI group exhibited significantly longer surgery time (MD = 57.36, 95 % CI = 13.31–101.40, P = 0.011), but no statistically significant difference was noted in conversion rate, R0 resection margins, and postoperative recurrence between the two groups.
Conclusion
Fluorescence navigation combined with 3D imaging technology is safe and feasible for guiding precise liver resection.
目的：评价荧光导航联合三维成像（FN&3DI）技术在肝脏精密切除术中的有效性和安全性。方法：系统检索PubMed、Web of Science、Embase和Cochrane Library数据库中关于荧光引导导航结合三维成像技术辅助精确肝脏切除术的所有英文出版物，截止日期为2024年9月。在评估纳入研究的质量并提取相关数据后，使用Stata 12.0软件进行meta分析。结果：本研究共纳入6项研究，共纳入451例患者，其中FN&3DI组207例，常规手术（CS）组244例。荟萃分析结果表明FN&3DI组表现出显著值低于c组在术中失血(平均差(MD) = -97.90,95%可信区间(CI) = -151.15至-44.66,P = 0.000],术中输血率(优势比(或) = 2.96,95% CI = 1.71 - -5.10,P = 0.000),住院(MD = -0.91,95% CI = -1.78到-0.04,P = 0.041),和整体术后并发症(MD = -0.91,95% CI = -1.78到-0.04,P = 0.041)。FN&3DI组手术时间明显长于前者（MD = 57.36,95% CI = 13.31-101.40,P = 0.011），但两组在转换率、R0切除边缘、术后复发率方面差异无统计学意义。结论：荧光导航结合三维成像技术指导肝脏精确切除安全可行。
{"title":"Efficacy and safety of fluorescence navigation combined with 3D imaging in precise liver resection: A systematic review and meta-analysis","authors":"Chunwei Xu, Xinhua Cui, Jiafei Che, Xiaojing Shen, Dingchao Chen","doi":"10.1016/j.pdpdt.2024.104446","DOIUrl":"10.1016/j.pdpdt.2024.104446","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effectiveness and safety of fluorescence navigation combined with three-dimensional imaging (FN&3DI) technology in precise liver resection.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for all English-language publications on fluorescence-guided navigation combined with three-dimensional (3D) imaging technology–assisted precise liver resection, with a cutoff date of July 2024. After assessing the quality of the included studies and extracting relevant data, a meta-analysis was performed using Stata 12.0 software.</div></div><div><h3>Results</h3><div>A total of 6 studies involving 451 patients were included in this study, with 207 patients in the FN&3DI group and 244 patients in the conventional surgery (CS) group. The meta-analysis results showed that the FN&3DI group exhibited significantly lower values than the CS group in terms of intraoperative blood loss [mean difference (MD) = –97.90, 95 % confidence intervals (CI) = –151.15 to –44.66, <em>P</em> = 0.000], intraoperative blood transfusion rates [odds ratios (OR) = 2.96, 95 % CI = 1.71–5.10, <em>P</em> = 0.000], hospital stay (MD = –0.91, 95 % CI = –1.78 to –0.04, <em>P</em> = 0.041), and overall postoperative complications (OR = 1.68, 95 % CI = 1.11 to 2.53, <em>P</em> = 0.014). However, the FN&3DI group exhibited significantly longer surgery time (MD = 57.36, 95 % CI = 13.31–101.40, <em>P</em> = 0.011), but no statistically significant difference was noted in conversion rate, R0 resection margins, and postoperative recurrence between the two groups.</div></div><div><h3>Conclusion</h3><div>Fluorescence navigation combined with 3D imaging technology is safe and feasible for guiding precise liver resection.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104446"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2025.104475
Qing wang , Lin-Bo He , Sha Li , Hong-Ling Liu , Yong Liu
Purpose
Utilizing Swept source optical coherence tomography angiography (SS-OCTA) investigates the changes in the vascular characteristics of the choriocapillaris and larger vascular layers, including Sattler's and Haller's layers, in the macular region of young myopia patients, in order to Enhance our comprehension of the underlying mechanisms of the pathogenesis of myopia.
Methods
A retrospective analysis was performed on 103 young adults (154 eyes) that underwent SS-OCTA. Axial lengths (AL) were measured, 64 eyes with AL < 26.5 mm as non-high myopia (NHM) and 90 eyes with AL ≥ 26.5 mm as high myopia (HM). Macular superficial capillary plexuses (SCP), deep capillary plexuses (DCP), choriocapillaris (CC) density, choroidal Sattler's and Haller's layers (CSHL) density, foveal avascular zone area (FAZ area), and subfoveal choroidal thickness (SFCT) were assessed. Multivariate regression analysis was employed to assess the effect of age,spherical equivalent(SE), axial length(AL),and SFCT on OCTA parameters.
Results
SCP and DCP densities in the foveal retina of NHM group were significantly lower than those in HM group(SCP 20.09 ± 4.30 vs. 21.54 ± 4.52, p = 0.043;DCP14.73 ± 3.93 vs. 16.21 ± 4.07, p = 0.024). Also, CC density subfoveal was significantly lower in NHM group compared to HM group(55.02 ± 2.39 vs. 56.37 ± 2.76, p = 0.0001); CSHL density subfoveal and parafoveal temporal were also significantly lower in NHM than HM(subfoveal 55.78 ± 4.67 vs. 58.17 ± 4.41, p = 0.002;parafoveal temporal 52.10 ± 3.48 vs. 54.06 ± 4.12, p = 0.002). In the multiple linear regression analysis, density of SCP in the foveal retina was increased with higher myopia(sβ=0.226, p = 0.047)and decreased with aging(sβ=-0.304, p = 0.001). Moreover, gradual decrease of the DCP was observed with aging(sβ=-0.227, p = 0.004). CSHL density subfoveal increased with the increase in AL(sβ=0.318, p = 0.007).
Conclusion
Age primarily influenced retinal vessel density, whereas axial length significantly affected Sattler's and Haller's layers. This also indicates that the subfoveal and parafoveal temporal CSHL densities are crucial for monitoring changes during myopia progression. Additionally, there appears to be a compensatory mechanism for high myopia to sustain visual function.
目的：利用扫源光学相干断层血管造影（SS-OCTA）研究青少年近视患者黄斑区毛膜毛细血管及大血管层（包括Sattler层和Haller层）血管特征的变化，以加深对近视发病机制的认识。方法：对103例青年人（154眼）行SS-OCTA手术进行回顾性分析。测量眼轴长度（AL）， AL < 26.5mm为非高度近视（NHM） 64眼，AL≥26.5mm为高度近视（HM） 90眼。评估黄斑浅毛细血管丛（SCP）、深毛细血管丛（DCP）、绒毛膜毛细血管丛（CC）密度、脉络膜Sattler’s和Haller’s层（CSHL）密度、中央凹无血管区面积（FAZ）和中央凹下脉络膜厚度（SFCT）。采用多元回归分析评估年龄、球等效（SE）、轴向长度（AL）和SFCT对OCTA参数的影响。结果：NHM组中央窝视网膜SCP、DCP密度显著低于HM组（SCP 20.09±4.30 vs. 21.54±4.52,p =0.043;DCP14.73±3.93 vs. 16.21±4.07,p =0.024）。NHM组中央凹下CC密度显著低于HM组（55.02±2.39 vs. 56.37±2.76,p =0.0001）；NHM组的CSHL密度也明显低于HM组（中央凹下55.78±4.67∶58.17±4.41,p =0.002；颞中央凹旁52.10±3.48∶54.06±4.12,p =0.002）。多元线性回归分析结果显示，近视程度越高，中央凹视网膜内SCP密度越高（sβ=0.226, p=0.047），年龄越大，SCP密度越低（sβ=-0.304, p=0.001）。随着年龄的增长，DCP逐渐降低（sβ=-0.227, p=0.004）。CSHL密度随AL的增加而增加（sβ=0.318, p=0.007）。结论：年龄主要影响视网膜血管密度，而轴向长度显著影响Sattler和Haller层。这也表明，中央凹下和中央凹旁颞部CSHL密度对于监测近视进展过程中的变化至关重要。此外，高度近视似乎有一种代偿机制来维持视觉功能。
{"title":"Evaluating choroidal vascular changes in young adults with high myopia utilizing swept source optical coherence tomography angiography","authors":"Qing wang , Lin-Bo He , Sha Li , Hong-Ling Liu , Yong Liu","doi":"10.1016/j.pdpdt.2025.104475","DOIUrl":"10.1016/j.pdpdt.2025.104475","url":null,"abstract":"<div><h3>Purpose</h3><div>Utilizing Swept source optical coherence tomography angiography (SS-OCTA) investigates the changes in the vascular characteristics of the choriocapillaris and larger vascular layers, including Sattler's and Haller's layers, in the macular region of young myopia patients, in order to Enhance our comprehension of the underlying mechanisms of the pathogenesis of myopia.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 103 young adults (154 eyes) that underwent SS-OCTA. Axial lengths (AL) were measured, 64 eyes with AL < 26.5 mm as non-high myopia (NHM) and 90 eyes with AL ≥ 26.5 mm as high myopia (HM). Macular superficial capillary plexuses (SCP), deep capillary plexuses (DCP), choriocapillaris (CC) density, choroidal Sattler's and Haller's layers (CSHL) density, foveal avascular zone area (FAZ area), and subfoveal choroidal thickness (SFCT) were assessed. Multivariate regression analysis was employed to assess the effect of age,spherical equivalent(SE), axial length(AL),and SFCT on OCTA parameters.</div></div><div><h3>Results</h3><div>SCP and DCP densities in the foveal retina of NHM group were significantly lower than those in HM group(SCP 20.09 ± 4.30 vs. 21.54 ± 4.52, <em>p</em> = 0.043;DCP14.73 ± 3.93 vs. 16.21 ± 4.07, <em>p</em> = 0.024). Also, CC density subfoveal was significantly lower in NHM group compared to HM group(55.02 ± 2.39 vs. 56.37 ± 2.76, <em>p</em> = 0.0001); CSHL density subfoveal and parafoveal temporal were also significantly lower in NHM than HM(subfoveal 55.78 ± 4.67 vs. 58.17 ± 4.41, <em>p</em> = 0.002;parafoveal temporal 52.10 ± 3.48 vs. 54.06 ± 4.12, <em>p</em> = 0.002). In the multiple linear regression analysis, density of SCP in the foveal retina was increased with higher myopia(sβ=0.226, <em>p</em> = 0.047)and decreased with aging(sβ=-0.304, <em>p</em> = 0.001). Moreover, gradual decrease of the DCP was observed with aging(sβ=-0.227, <em>p</em> = 0.004). CSHL density subfoveal increased with the increase in AL(sβ=0.318, <em>p</em> = 0.007).</div></div><div><h3>Conclusion</h3><div>Age primarily influenced retinal vessel density, whereas axial length significantly affected Sattler's and Haller's layers. This also indicates that the subfoveal and parafoveal temporal CSHL densities are crucial for monitoring changes during myopia progression. Additionally, there appears to be a compensatory mechanism for high myopia to sustain visual function.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104475"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pdpdt.2024.104423
Isabella Pellegrino, Mariagrazia Avella
{"title":"Choroidal vascular parameters in patients with type 2 diabetes mellitus","authors":"Isabella Pellegrino, Mariagrazia Avella","doi":"10.1016/j.pdpdt.2024.104423","DOIUrl":"10.1016/j.pdpdt.2024.104423","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104423"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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