Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Age and gender-related changes in choroidal thickness: Insights from deep learning analysis of swept-source OCT images","authors":"Dan Song ,&nbsp;Guanzheng Wang ,&nbsp;Guangfeng Liu ,&nbsp;Chengxia Zhang ,&nbsp;Bin Lv ,&nbsp;Yuan Ni ,&nbsp;Guotong Xie","doi":"10.1016/j.pdpdt.2025.104511","DOIUrl":"10.1016/j.pdpdt.2025.104511","url":null,"abstract":"<div><h3>Background</h3><div>The choroid is a vital vascular layer of the eye, essential for maintaining ocular health. Understanding its structural variations, particularly choroidal thickness (CT), is crucial for the early detection of diseases, such as age-related macular degeneration (AMD), high myopia (HM), and diabetes mellitus (DM). Recent advancements in deep learning have significantly improved the segmentation and measurement of choroidal layers.</div></div><div><h3>Objective</h3><div>This study aims to investigate age- and gender-related changes in CT and its components through deep learning analysis of swept-source optical coherence tomography (SS-OCT) images.</div></div><div><h3>Methods</h3><div>A total of 262 participants (136 females and 126 males) were recruited from Peking University International Hospital. Exclusion criteria included ocular pathologies and systemic conditions. SS-OCT was utilized for CT, Sattler layer-choriocapillaris complex thickness (SLCCT), and Haller layer thickness (HLT) measurements. auto-measurement method, based on deep learning algorithms, ensured accuracy. Ethics approval and informed consent were obtained from all participants.</div></div><div><h3>Findings</h3><div>Significant thinning of CT and SLCCT was observed after the age of 60, with HLT declining after the age of 30. Females exhibited marked thinning between the ages of 40 and 50, while males began to show thinning at age 60.</div></div><div><h3>Conclusion and Implications</h3><div>This research highlights age-related changes in choroidal thickness, with a particular emphasis on gender differences. The findings suggest that females experience earlier thinning, potentially attributable to hormonal changes. Additionally, the study validates the efficiency of deep learning algorithms in measuring choroidal thickness, thereby enhancing the reliability of clinical practice.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104511"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy","authors":"Yuqing Wang ,&nbsp;Yiting Xu ,&nbsp;Yong Qu ,&nbsp;Yifang Jin ,&nbsp;Juanmei Cao ,&nbsp;Jinshan Zhan ,&nbsp;Zhuoxia Li ,&nbsp;Chuxing Chai ,&nbsp;Changzheng Huang ,&nbsp;Min Li","doi":"10.1016/j.pdpdt.2024.104463","DOIUrl":"10.1016/j.pdpdt.2024.104463","url":null,"abstract":"<div><div>Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies and exploration of immunotherapy represent additional strategies for tumor treatment. Photodynamic therapy (PDT) is a relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis. Ferroptosis, an iron-dependent type of programmed cell death characterized by accumulation of reactive oxygen species and lipid peroxidation products to lethal levels, has emerged as an attractive target trigger for tumor therapies. Recent research has revealed a close association between PDT and ferroptosis, suggesting that combining ferroptosis inducers with PDT could strengthen their synergistic anti-tumor efficiency. Here in this review, we discuss the rationale for combining PDT with ferroptosis inducers and highlight the progress of single-molecule photosensitizers to induce ferroptosis, as well as the applications of photosensitizers combined with other therapeutic drugs for collaborative therapy. Furthermore, given the current research dilemma, we propose potential therapeutic strategies to advance the combined usage of PDT and ferroptosis inducers, providing the basis and guidelines for prospective clinical translation and research directionality with regard to PDT.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104463"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anterior chamber depth measured by three different anterior segment analysis systems","authors":"Han Song ,&nbsp;Wei Yang ,&nbsp;Chunliu Yang ,&nbsp;Qing Sun","doi":"10.1016/j.pdpdt.2025.104471","DOIUrl":"10.1016/j.pdpdt.2025.104471","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to compare and evaluate the correlation and agreement among three distinct anterior segment analysis systems in measuring anterior chamber depth (ACD) in healthy myopic individuals.</div></div><div><h3>Methods</h3><div>Myopic patients who underwent preoperative assessments at our hospital's refractive surgery department from January 2021 to December 2023 were included in this investigation. ACD was measured using three anterior segment analysis systems: Pentacam, Sirius, and IOLMaster 700. Statistical analyses were performed using SPSS software. The Pearson method was utilized to analyze correlations between the measured values of the three groups. Bland-Altman scatter plots were generated using MedCalc software, with 95 % limits of agreement applied to assess consistency among the datasets.</div></div><div><h3>Results</h3><div>The mean anterior chamber depth (ACD) measured by the Pentacam, Sirius, and IOLMaster 700 was found to be 3.26 ± 0.26 mm, 3.30 ± 0.26 mm and 3.22 ± 0.25 mm, respectively. The mean ACD values obtained from these three devices exhibited statistically significant differences (<em>p</em> &lt; 0.05). Furthermore, the ACD measurements from all three devices demonstrated a strong positive correlation with each other, <em>p</em> &lt; 0.001, <em>r</em> = 0.965 (Pentacam and Sirius), <em>r</em> = 0.955 (Pentacam and IOLMaster 700), and <em>r</em> = 0.966 (Sirius and IOLMaster 700). The respective 95 % LoAs were -1.16 ∼ -0.73(Pentacam and Sirius);0.55 ∼ 1.05(Pentacam and IOLMaster 700);1.53 ∼ 1.96 (Sirius and IOLMaster 700).</div></div><div><h3>Conclusion</h3><div>There is a high positive correlation between the anterior chamber depth (ACD) measured by three different anterior segment analysis systems in healthy myopic eyes. However, the differences in the measurement of different optical devices should be considered in clinical work, and it is not recommended to interchange them.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104471"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting plaque regression based on plaque characteristics identified by optical coherence tomography: A retrospective study","authors":"Cheng-Hui Fan ,&nbsp;Lyu-fan Chen ,&nbsp;Jing Cheng ,&nbsp;Yi-Qiong Wang ,&nbsp;Ling-Hao Xu ,&nbsp;Ji-Ming Li","doi":"10.1016/j.pdpdt.2025.104473","DOIUrl":"10.1016/j.pdpdt.2025.104473","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerosis is a lipid-driven, systemic immune-inflammatory disease characterized by the accumulation of plaque within the arterial walls. Plaque regression can occur following appropriate treatment interventions. Optical coherence tomography (OCT), a high-resolution imaging modality, is frequently employed to assess plaque morphology. This study aims to explore the correlation between plaque characteristics identified using OCT, particularly macrophage infiltration, and subsequent plaque regression.</div></div><div><h3>Methods</h3><div>In this retrospective study, data from 112 individuals with coronary artery plaques, who underwent OCT imaging at our hospital, between June 2019 and June 2024, were evaluated. Plaques were classified as lipid-rich, fibrous, or calcified based on the initial OCT findings. Macrophage infiltration levels within each plaque type were quantified. After one year of follow-up, repeat OCT imaging was performed to evaluate plaque regression. Statistical analyses were conducted to assess the relationship between initial plaque characteristics and regression outcomes.</div></div><div><h3>Results</h3><div>Plaques that underwent regression were more commonly lipid-rich and exhibited higher levels of macrophage infiltration compared to those without regression. Multivariate analysis identified the histological inflammation score (HIS) as an independent factor influencing plaque regression.</div></div><div><h3>Conclusion</h3><div>Macrophage-rich plaques, as detected by OCT, are significant predictors of plaque regression. The identification of vulnerable plaque features through OCT can enhance the early diagnosis and treatment strategies for atherosclerotic cardiovascular disease.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104473"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent experience","authors":"Gennady Meerovich ,&nbsp;Evgeniya Kogan ,&nbsp;Igor Romanishkin ,&nbsp;Nikolay Zharkov ,&nbsp;Sofiya Avraamova ,&nbsp;Elena Shchelokova ,&nbsp;Ekaterina Akhlyustina ,&nbsp;Marina Strakhovskaya ,&nbsp;Irina Meerovich ,&nbsp;Sofya Demura ,&nbsp;Irina Tiganova ,&nbsp;Yulia Romanova ,&nbsp;Zhi-Long Chen ,&nbsp;Igor Reshetov","doi":"10.1016/j.pdpdt.2024.104447","DOIUrl":"10.1016/j.pdpdt.2024.104447","url":null,"abstract":"<div><div>The problem of treating cancer patients with lung cancer has become more difficult due to the SARS-CoV-2 viral infection and concomitant bacterial lesions. The analysis shows that the photodynamic effect of long-wavelength polycationic photosensitizers suppresses the tumor process (including the destruction of cancer stem cells), SARS-CoV-2 coronavirus infection, Gram-positive and Gram-negative bacteria, including those that can cause pneumonia. Therefore, the photodynamic approach using such photosensitizers is promising for the development of an effective treatment method for patients with lung cancer, including those with SARS-CoV-2 infection and bacterial complications.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104447"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes","authors":"Yuanyuan Liu ,&nbsp;Xueli Yang ,&nbsp;Wei Zhou,&nbsp;Jinguo Yu,&nbsp;Song Chen,&nbsp;Tiangeng He,&nbsp;Caiyun You,&nbsp;Xiangda Meng,&nbsp;Mengyu Liao,&nbsp;Yi Lei,&nbsp;Hua Yan","doi":"10.1016/j.pdpdt.2024.104458","DOIUrl":"10.1016/j.pdpdt.2024.104458","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated the association between photoreceptor structural restoration and visual function outcomes in patients undergoing surgery for closed macular holes (MHs). Using adaptive optics scanning laser ophthalmoscopy (AOSLO) and microperimetry, we aimed to provide a more detailed understanding of photoreceptor recovery and visual improvement in closed MHs.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study of 31 eyes of 28 patients who underwent vitrectomy with internal limiting membrane (ILM) peeling to treat idiopathic MHs. Visual and structural outcomes were monitored 3 months to 2 years postoperatively: best-corrected visual acuity (BCVA), MH diameter and duration, optical coherence tomography (OCT) images, 4° retinal mean sensitivity (RMS), fixation rates, 68.2 % BCEA (binary contour ellipse area) of microperimetry, and cone density as measured by AOSLO. Based on the OCT findings, the patients were categorized into two groups: type 1 (closed MH with no neurosensory defect at the fovea) and type 2 (closed MH with a foveal neurosensory defect).</div></div><div><h3>Results</h3><div>The analysis revealed that type 1 closures resulted in significantly better photoreceptor recovery, with cone cells migrating toward the fovea and forming dense islets, consistent with the integrity of the inner segment/outer segment layer on OCT. These patients also had better postoperative BCVA and higher RMS rather than fixation improvement, aligning with the improved cone density. In contrast, type 2 closures exhibited sparse cone distribution and a prevalence of large, high-density cells, possibly indicating glial cell proliferation and exposed retinal pigment epithelium (RPE). MH size, rather than duration or preoperative BCVA, was a key determinant of type 1 closure outcomes.</div></div><div><h3>Conclusion</h3><div>AOSLO is a valuable tool for evaluating microstructural healing in MHs and reveals that type 1 closure, characterized by cone migration, leads to greater neuroretinal repair and improved BCVA and retinal sensitivity. Meanwhile, type 2 closures, marked by less photoreceptor recovery and higher glial proliferation, correspond to poorer visual function outcomes. This study highlights the role of photoreceptor density and migration in achieving optimal visual function post-surgery for MH closure.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104458"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzo-pyrrolidinyl substituted silicon phthalocyanines: A novel two-photon lysosomal nanoprobe for in vitro photodynamic therapy","authors":"Xiuqin Chen ,&nbsp;Guizhi Chen ,&nbsp;Sitong Cao ,&nbsp;Ruoxin Ye ,&nbsp;Ruoyi Qiu ,&nbsp;Xiangyu Yang ,&nbsp;Yiru Peng ,&nbsp;Hong Sun","doi":"10.1016/j.pdpdt.2024.104431","DOIUrl":"10.1016/j.pdpdt.2024.104431","url":null,"abstract":"<div><div>Lysosomes are pivotal in diverse physiological phenomena, encompassing autophagy, apoptosis, and cellular senescence. The demand for precise tumors treatment has led to the development of specific lysosome-targeting probes capable of elucidating lysosomal dynamics and facilitating targeted cell death. In this research, we report the synthesis and characterization of a novel benzopyrrolidinyl-substituted silicon phthalocyanine (Py-SiPc), designed for selective lysosome labeling and Fluorescence imaging-guided in vitro photodynamic therapy. Furthermore, we encapsulated Py-SiPc within a biocompatible nanocarrier, dipalmitoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE), to create water-soluble nanoparticles (DSPE@Py-SiPc). These nanoparticles exhibit exceptional lysosome labeling capabilities, as evidenced by bioimaging techniques. Upon exposure to laser irradiation, DSPE@Py-SiPc efficiently induces the production of reactive oxygen species, impairing lysosomal function and triggering lysosomal-mediated cell death. The DSPE@Py-SiPc system emerges as a promising photosensitizer.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104431"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro photodynamic therapy of Candida albicans, the cause of vulvovaginal candidiasis, is enhanced by Bacillus and Enterococcus probiotics","authors":"Zeinab Ghanbari,&nbsp;Ali Makhdoumi","doi":"10.1016/j.pdpdt.2025.104483","DOIUrl":"10.1016/j.pdpdt.2025.104483","url":null,"abstract":"<div><h3>Background</h3><div><em>Candida albicans</em> is the primary cause of vulvovaginal candidiasis, a worldwide health concern for women. The use of supplemental methods, such as antimicrobial photodynamic therapy (aPDT) and probiotics, was promoted by the ineffectiveness of the existing antifungal drugs.</div></div><div><h3>Methods</h3><div>This study examines the combined effects of probiotics (<em>Bacillus</em> and <em>Enterococcus</em> isolated from the fermented pickles) and PDT (using red laser (655 nm, 18 J/cm²) as a light source and methylene blue dye (30 mg/mL) as a photosensitizer) on the <em>in vitro</em> virulence activity of <em>C. albicans</em> including growth, biofilm formation, antifungal resistance, biofilm elimination, and biofilm dispersion.</div></div><div><h3>Results</h3><div>The probiotic strains demonstrated a higher resistance to PDT compared to the fungal cell. <em>Bacillus</em> and <em>Enterococcus</em> enhanced the antifungal effects of PDT on planktonic <em>Candida</em> cells in both pre-PDT and post-PDT interactions. The inhibition of biofilm formation by PDT was improved upon interaction with <em>Bacillus</em> (70 %) and <em>Enterococcus</em> (58 %). The eradication of <em>Candida</em> biofilm using PDT was increased after a combination with <em>Bacillus</em> (67 %) and <em>Enterococcus</em> (46 %). The nystatin resistance of the fungal biofilm following PDT treatment was decreased from (µg/ml) 25 to 6.25 due to the interaction with both probiotic strains. Fungal cell dispersion from the biofilm after PDT treatment diminished by 18 % and 25 % in the presence of <em>Bacillus</em> and <em>Enterococcus</em> strains. <em>Galleria mellonella</em> mortality was significantly changed following the PDT of the fungi/probiotic-injected larvae.</div></div><div><h3>Conclusions</h3><div>This synergistic activity suggests the use of probiotics/PDT as a supplemental treatment for vulvovaginal candidiasis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104483"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of platelet-rich fibrin and photobiomodulation on bone regeneration in MC3T3-E1 Preosteoblasts","authors":"Ling-Hung Chou ,&nbsp;Tzu-Sen Yang ,&nbsp;Pei-Chun Wong ,&nbsp;Ying-Chun Chen","doi":"10.1016/j.pdpdt.2024.104436","DOIUrl":"10.1016/j.pdpdt.2024.104436","url":null,"abstract":"<div><h3>Background</h3><div>Platelet-rich fibrin (PRF) and Photobiomodulation (PBM) are established methods for promoting bone healing. PRF enhances cell proliferation and migration due to its rich concentration of growth factors, while PBM stimulates tissue repair through mitochondrial activation. Despite their efficacies, no in-depth studies have explored the synergistic effects of combining PRF and PBM.</div></div><div><h3>Methods</h3><div>PRF was prepared at 50 % and 100 % concentrations, and PBM was applied using an 830 nm near-infrared laser at a dose of 5 J/cm². Cell viability, migration, and calcium deposition were assessed over seven and fourteen days.</div></div><div><h3>Results</h3><div>The combination of PRF and PBM significantly improved cell viability, migration, and calcium deposition, with the most notable effects observed after seven and fourteen days. However, a slight decrease in calcium deposition was noted in the 100 % PRF combined with the PBM group, suggesting a potential feedback mechanism at higher PRF concentrations.</div></div><div><h3>Conclusions</h3><div>This study explores the synergistic effects of PRF and PBM, offering new insights into optimizing bone tissue engineering strategies. The findings highlight the potential of this combined approach in enhancing bone regeneration, although further research is needed to refine the optimal conditions for these therapies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104436"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus","authors":"Weiwei Shi ,&nbsp;Fang Wang ,&nbsp;Liangliang Chen ,&nbsp;Ruzhi Zhang","doi":"10.1016/j.pdpdt.2024.104439","DOIUrl":"10.1016/j.pdpdt.2024.104439","url":null,"abstract":"<div><h3>Background</h3><div>Genital lichen sclerosus (GLS) is a chronic inflammatory skin disease affecting the genital and anal areas. Treatment of refractory remains a challenge in clinical practice.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for refractory GLS.</div></div><div><h3>Methods</h3><div>Thirty-five patients with histopathologically confirmed GLS (including 32 females and 3 males) were treated with 5-ALA PDT. Lesion pretreatment was performed to enhance photosensitizer penetration, and fluorescence diagnosis was used for precise point-to-point treatment. Efficacy and safety were systematically evaluated by assessing treatment outcomes, symptom improvement, side effects and maintenance of efficacy over a 6-month follow-up period.</div></div><div><h3>Results</h3><div>After treatment, most patients experienced significant relief of pruritus, improved skin elasticity and color, and reduced lesion area. After 6 treatment sessions, 11 patients (31.43 %) achieved complete resolution of pruritus, with 3 patients (8.57 %) achieving complete remission after 3 sessions. Cattaneo scores decreased significantly after treatment and during follow-up (<em>P</em> &lt; 0.05). Adverse reactions were mainly mild pain, which could be relieved by ice compression or oral analgesics.</div></div><div><h3>Conclusions</h3><div>5-ALA PDT shows significant efficacy and good safety for refractory GLS, improving the clinical symptoms and signs of patients, and warrants wider clinical application.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104439"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}