Photodiagnosis and Photodynamic Therapy最新文献_第4页

Prediction model for the risk of vitreous haemorrhage after vitrectomy combined with intraocular injection for the treatment of proliferative diabetic retinopathy 玻璃体切除术联合眼内注射治疗增殖性糖尿病视网膜病变后玻璃体出血风险预测模型。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-09 DOI: 10.1016/j.pdpdt.2025.105313

Shasha Yao, Chunfang Gan, Rugang Pan

Objective

The purpose of this study was to develop a lightweight multimodal deep learning model for accurately predicting the risk of postoperative vitreous cavity haemorrhage (POVCH) following vitrectomy with intraocular pharmacotherapy in patients with proliferative diabetic retinopathy (PDR).

Methods

This retrospective study included patients with PDR who underwent vitrectomy combined with intraocular medication for the first time. After applying the exclusion criteria, 1318 eyes from 968 patients were analysed. A lightweight multimodal deep learning model was developed by integrating ultra-widefield fluorescein angiography images, processed using an EfficientNet-V2 backbone, using clinical data from a multilayer perceptron. The model was trained and evaluated using a stratified four-fold cross-validation approach, and an independent external test set comprising 264 eyes was used to assess generalisability.

Results

On the external test set, the model achieved an area under the receiver operating characteristic curve (AUROC) of 0.978 (95 % CI: 0.952–0.994) and an area under the precision-recall curve of 0.957. Accuracy was 0.914, with a Brier score of 0.056. The model demonstrated excellent calibration (slope: 0.97; intercept: −0.03). Decision curve analysis indicated a net benefit increase of 0.031 at a 25 % risk threshold. Interpretability analyses revealed that the model’s focus, via Gradient-weighted Class Activation Mapping Plus, aligned with clinical areas of neovascularisation and retinal ischaemia. SHapley Additive exPlanations analysis identified the ischaemia index, leakage index and neovascularisation area as key predictors. The model outperformed the best traditional CatBoost model, with an absolute AUROC improvement of 0.09.

Conclusion

The lightweight multimodal deep learning model integrating ultra-widefield fluorescein angiography images and clinical data demonstrated advantages in predicting the risk of POVCH after PDR surgery, with high accuracy, good calibration, excellent clinical utility and interpretability and low resource requirements.

目的：本研究的目的是建立一个轻量级的多模态深度学习模型，以准确预测增殖性糖尿病视网膜病变（PDR）患者玻璃体切除术合并眼内药物治疗后玻璃体腔出血（POVCH）的风险。方法：对首次行玻璃体切除联合眼内药物治疗的PDR患者进行回顾性研究。应用排除标准后，对968例患者的1318只眼睛进行了分析。通过整合超宽视场荧光素血管造影图像，使用高效网络- v2主干处理，并使用多层感知器的临床数据，开发了一个轻量级的多模态深度学习模型。使用分层四重交叉验证方法对模型进行训练和评估，并使用包含264只眼睛的独立外部测试集来评估通用性。结果：在外部测试集上，该模型的受试者工作特征曲线下面积（AUROC）为0.978 (95% CI: 0.952-0.994)，精密度-召回率曲线下面积为0.957。准确率为0.914，Brier评分为0.056。该模型具有良好的校准效果（斜率：0.97；截距：-0.03）。决策曲线分析表明，在25%的风险阈值下，净收益增加0.031。可解释性分析显示，通过梯度加权类激活映射Plus Plus，该模型的焦点与新生血管和视网膜缺血的临床区域一致。SHapley加性解释分析确定了缺血指数、渗漏指数和新生血管面积是关键的预测因子。该模型优于传统的最佳CatBoost模型，AUROC绝对提高了0.09。结论：整合超宽视场荧光素血管造影图像和临床数据的轻量级多模态深度学习模型在预测PDR术后POVCH风险方面具有优势，具有准确性高、校准性好、临床实用性和可解释性好、资源需求低等特点。

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引用次数: 0

Repeated visual perceptual micro-training enhances neural microplasticity in children with ametropic amblyopia: A clinical observation 反复视知觉微训练增强儿童屈光性弱视神经微可塑性的临床观察。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-09 DOI: 10.1016/j.pdpdt.2025.105311

Fang-Fang Lan, Wu-Xiao Zhao, Lu Gan, Yan Luo, Zhi-Chao Li

Objective

The aim of this study was to evaluate the effects of repeated visual-perceptual micro training on neural microplasticity in children diagnosed with ametropic amblyopia, with a focus on changes in best-corrected visual acuity (BCVA), binocular visual function, and suppression.

Methods

A total of 35 children with ametropic amblyopia (mean age: 6.80 years) underwent intervention using a binocular visual perceptual neural plasticity training system. The training protocol consisted of 20 sessions, administered five times per week, each lasting 40 min. BCVA, suppression status, and stereopsis were assessed at baseline (T0), after five sessions (T1), after ten sessions (T2), and 4 weeks post-intervention (T3).

Results

Following ten training sessions, the mean BCVA improved from 0.72 to 0.88 in the right eye and from 0.70 to 0.90 in the left eye (p < 0.001). The prevalence of foveal suppression decreased from 51.43 % to 14.29 %, while the proportion of participants without suppression increased from 34.29 % to 57.14 % (p = 0.025). Significant improvements in fine stereopsis were observed at both 0.8 m and 1.5 m distances, with the proportion of individuals reaching grade 3–4 increasing to 82.86 % and 71.43 %, respectively (p < 0.01). The observed therapeutic effects remained stable throughout the follow-up period.

Conclusion

Repeated visual perceptual micro-training demonstrated significant improvements in BCVA, binocular visual function, and suppression in children with ametropic amblyopia. These effects followed a cumulative enhancement pattern and remained stable during the 4-week post-training follow-up period, suggesting potential clinical applicability in amblyopia rehabilitation while highlighting the need for longer-term evaluation.

目的：本研究旨在评估反复视知觉微训练对屈光性弱视儿童神经微可塑性的影响，重点关注最佳矫正视力（BCVA）、双眼视功能和抑制的变化。方法：采用双眼视觉知觉神经可塑性训练系统对35例屈光性弱视儿童（平均年龄6.80岁）进行干预。训练方案包括20次训练，每周五次，每次持续40分钟。分别在基线（T0）、5个疗程（T1）、10个疗程（T2）和干预后4周（T3）评估BCVA、抑制状态和立体视觉。结果：经过10次训练，右眼平均BCVA从0.72提高到0.88，左眼从0.70提高到0.90 （p < 0.001）。中央凹抑制的患病率从51.43%下降到14.29%，而未抑制的参与者比例从34.29%上升到57.14% （p = 0.025）。在0.8m和1.5m处，精细立体视觉均有显著改善，达到3-4级的个体比例分别增加到82.86%和71.43% （p < 0.01）。观察到的治疗效果在整个随访期间保持稳定。结论：反复视觉知觉微训练对屈光性弱视儿童的BCVA、双眼视功能及抑制均有显著改善。这些效果呈累积增强模式，并在训练后4周的随访期间保持稳定，提示在弱视康复中潜在的临床适用性，同时强调需要进行长期评估。

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引用次数: 0

OCT-based retinal biomarkers forecast central nervous system structural decline in Parkinson’s disease: A longitudinal multimodal study within the Persian Cohort 基于oct的视网膜生物标志物预测帕金森病中枢神经系统结构衰退：波斯队列的纵向多模式研究

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-08 DOI: 10.1016/j.pdpdt.2025.105310

Farzane Nikparast , Nooshin Akbari-Sharak , Zohreh Ganji , Ali Shoeibi , Naser Shoeibi , Hoda Zare

Background and Objective

Parkinson's disease (PD) is among the most prevalent progressive neurodegenerative disorders, impacting both the central and peripheral nervous systems.This longitudinal study investigates whether structural changes in the retina, due to its developmental and structural similarities with the brain, can act as early indicators of brain alterations in patients with PD.

Methods

Data from 29 PD patients and 25 healthy controls were analyzed. After a mean interval of 2.7 years after retina imaging, all participants underwent a 1.5T magnetic resonance imaging (MRI) Scan. Image processing was performed using 3D Slicer and the CAT12 toolbox, while statistical analyses were conducted with R software.

Results

In healthy controls, a significant positive correlation was observed between gray and white matter volumes and peripapillary retinal nerve fiber layer (pRNFL) thickness (r = 0.5, p < 0.05) and (r = 0.4, p < 0.05). In contrast, PD patients showed a significant association between increased CSF volume and reduced pRNFL thickness and optic nerve rim volume (r = -0.50 to -0.40; p < 0.05) and (r = -0.50; p < 0.05), respectively. Moreover, neuromelanin signal intensity in the substantia nigra correlated positively and significantly with pRNFL thickness in nasal and superior sectors exclusively in the PD group (r = 0.40 to 0.60; p < 0.05).

Conclusion

Retinal alterations in PD are closely aligned with concurrent brain neurodegeneration and may serve as predictive biomarkers. These findings suggest that OCT, when combined with MRI, may support a non-invasive strategy for early risk stratification and longitudinal monitoring of PD.

背景与目的：帕金森病（PD）是最常见的进行性神经退行性疾病之一，影响中枢和周围神经系统。这项纵向研究调查了视网膜的结构变化是否可以作为PD患者大脑改变的早期指标，因为视网膜的发育和结构与大脑相似。方法：分析29例PD患者和25例健康对照者的资料。在视网膜成像平均间隔2.7年后，所有参与者都进行了1.5T磁共振成像（MRI）扫描。使用3D Slicer和CAT12工具箱进行图像处理，使用R软件进行统计分析。结果：在健康对照组中，灰质和白质体积与乳头周围视网膜神经纤维层（pRNFL）厚度呈显著正相关（r = 0.5,p < 0.05）和（r = 0.4,p < 0.05）。相比之下，PD患者脑脊液体积的增加与pRNFL厚度和视神经边缘体积的减少之间存在显著相关性（r = -0.50 ~ -0.40,p < 0.05）和（r = -0.50,p < 0.05）。PD组黑质神经黑色素信号强度与鼻部及上段pRNFL厚度呈正相关（r = 0.40 ~ 0.60;p < 0.05）。结论：PD患者视网膜病变与并发脑神经退行性变密切相关，可作为预测性生物标志物。这些发现表明，当OCT与MRI相结合时，可能支持一种无创的PD早期风险分层和纵向监测策略。

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引用次数: 0

Comparative efficacy of photodynamic therapy versus conventional therapies for actinic keratosis: A systematic review and meta-analysis 光动力疗法与传统疗法治疗光化性角化病的比较疗效：系统综述和荟萃分析。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-06 DOI: 10.1016/j.pdpdt.2025.105308

ALA'A Suwait Deeb AL Suwait , Rongyi Chen , Ziad Fayez Mohammad Alkouz , Jiaxi Lai , Kaixin Li , Xiaoshuang Liang , Siqi Li , Rehab Alhejairi , Ashraf Suwait Deeb AL Suwait , Yongfeng Chen

Background

Photodynamic therapy (PDT) is widely used for actinic keratosis (AK), but its comparative effectiveness versus conventional therapies remains unclear.

Objective

To systematically evaluate PDT efficacy compared with cryotherapy, 5-fluorouracil, and imiquimod for AK treatment through meta-analysis.

Methods

We conducted a systematic review and meta-analysis, searching PubMed, Embase, Cochrane, and Web of Science databases through June 2025 for randomized controlled trials comparing PDT with active treatments. Primary outcome was complete clearance rate. Risk ratios (RR) with 95 % confidence intervals (CI) were calculated using random-effects models.

Results

Thirteen studies (n = 1841) were included. 5-Fluorouracil demonstrated superior efficacy versus PDT at 12 months (74.7 % vs 37.7 %; RR 0.50, 95 % CI 0.40–0.64, P < 0.001). PDT showed comparable efficacy to cryotherapy overall (63.5 % vs 52.4 %, P = 0.154) but was superior for Grade III lesions (56.9 % vs 13.4 %, P = 0.021). Against imiquimod, results varied by population: imiquimod was more effective in immunocompetent patients (53.9 % vs 37.7 %, P = 0.006), while PDT was superior in organ transplant recipients (78 % vs 61 %, P < 0.001). Combination 5-FU pretreatment enhanced PDT efficacy (87 % vs 74 %, P < 0.0001). PDT achieved better cosmetic outcomes than cryotherapy (hypopigmentation: 0–3 % vs 31 %, P < 0.001) and higher patient satisfaction than imiquimod (90 % vs 61 %, P < 0.003).

Conclusions

While 5-fluorouracil monotherapy shows superior efficacy, PDT offers advantages for specific populations and Grade III lesions. Combination approaches optimize outcomes while maintaining PDT’s favorable cosmetic and tolerability profile.

背景：光动力疗法（PDT）广泛用于光化性角化病（AK），但其与传统疗法的比较效果尚不清楚。目的：通过meta分析，系统评价PDT与冷冻疗法、5-氟尿嘧啶、咪喹莫特治疗AK的疗效。方法：我们进行了系统回顾和荟萃分析，检索PubMed、Embase、Cochrane和Web of Science数据库，检索截至2025年6月的随机对照试验，比较PDT与积极治疗。主要终点为完全清除率。使用随机效应模型计算95%置信区间（CI）的风险比（RR）。结果：纳入13项研究（n=1,841）。5-氟尿嘧啶在12个月时的疗效优于PDT （74.7% vs 37.7%; RR 0.50, 95% CI 0.40-0.64, P < 0.001）。PDT的总体疗效与冷冻疗法相当（63.5% vs 52.4%, P = 0.154），但对III级病变的疗效更好（56.9% vs 13.4%, P = 0.021）。对于咪喹莫特，结果因人群而异：咪喹莫特对免疫功能正常的患者更有效（53.9%比37.7%,P = 0.006），而PDT对器官移植受体更有效（78%比61%，P < 0.001）。联合5-FU预处理可提高PDT疗效（87% vs 74%, P < 0.0001）。PDT的美容效果优于冷冻疗法（色素沉着：0-3% vs 31%， P < 0.001），患者满意度高于咪喹莫特（90% vs 61%, P < 0.003）。结论：虽然5-氟尿嘧啶单药治疗疗效优越，但PDT治疗对特定人群和III级病变具有优势。联合方法优化结果，同时保持PDT良好的外观和耐受性。

{"title":"Comparative efficacy of photodynamic therapy versus conventional therapies for actinic keratosis: A systematic review and meta-analysis","authors":"ALA'A Suwait Deeb AL Suwait , Rongyi Chen , Ziad Fayez Mohammad Alkouz , Jiaxi Lai , Kaixin Li , Xiaoshuang Liang , Siqi Li , Rehab Alhejairi , Ashraf Suwait Deeb AL Suwait , Yongfeng Chen","doi":"10.1016/j.pdpdt.2025.105308","DOIUrl":"10.1016/j.pdpdt.2025.105308","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) is widely used for actinic keratosis (AK), but its comparative effectiveness versus conventional therapies remains unclear.</div></div><div><h3>Objective</h3><div>To systematically evaluate PDT efficacy compared with cryotherapy, 5-fluorouracil, and imiquimod for AK treatment through meta-analysis.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis, searching PubMed, Embase, Cochrane, and Web of Science databases through June 2025 for randomized controlled trials comparing PDT with active treatments. Primary outcome was complete clearance rate. Risk ratios (RR) with 95 % confidence intervals (CI) were calculated using random-effects models.</div></div><div><h3>Results</h3><div>Thirteen studies (<em>n</em> = 1841) were included. 5-Fluorouracil demonstrated superior efficacy versus PDT at 12 months (74.7 % vs 37.7 %; RR 0.50, 95 % CI 0.40–0.64, <em>P</em> < 0.001). PDT showed comparable efficacy to cryotherapy overall (63.5 % vs 52.4 %, <em>P =</em> 0.154) but was superior for Grade III lesions (56.9 % vs 13.4 %, <em>P</em> = 0.021). Against imiquimod, results varied by population: imiquimod was more effective in immunocompetent patients (53.9 % vs 37.7 %, <em>P =</em> 0.006), while PDT was superior in organ transplant recipients (78 % vs 61 %, <em>P</em> < 0.001). Combination 5-FU pretreatment enhanced PDT efficacy (87 % vs 74 %, <em>P</em> < 0.0001). PDT achieved better cosmetic outcomes than cryotherapy (hypopigmentation: 0–3 % vs 31 %, <em>P</em> < 0.001) and higher patient satisfaction than imiquimod (90 % vs 61 %, <em>P</em> < 0.003).</div></div><div><h3>Conclusions</h3><div>While 5-fluorouracil monotherapy shows superior efficacy, PDT offers advantages for specific populations and Grade III lesions. Combination approaches optimize outcomes while maintaining PDT’s favorable cosmetic and tolerability profile.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105308"},"PeriodicalIF":2.6,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of magnesium-conditioned chitosan hydrogels and photobiomodulation on MC3T3-E1 preosteoblast function 镁调壳聚糖水凝胶和光生物调节对MC3T3-E1成骨前细胞功能的协同作用。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-05 DOI: 10.1016/j.pdpdt.2025.105307

Hao-Hsuan Chiu , Pei-Chun Wong , Ying-Chun Chen

Background

Magnesium (Mg) and photobiomodulation (PBM) have independently been reported to promote osteogenesis, but their combined effects remain unclear.

Methods

Mg-conditioned chitosan hygrogels (0,20, and 50 mol%) were prepared, and conditioned media were applied to MC3T3-E1 preosteoblasts with or without near-infrared PBM (830 nm, 5 J/cm²). Cell viability, migration, and calcium deposition were assessed (n = 3 biological replicates per group).

Results

High Mg reduced cell migration and mineralization, whereas PBM significantly enhanced calcium deposition and partially restored viability at early time points (p < 0.05). A notable synergistic effect was observed at 20 mol% Mg combined with PBM, particularly at specific time points, indicating a condition-dependent rather than uniformly optimal response.

Conclusion

The combination of Mg-conditioned hydrogels and PBM enhanced osteogenic responses in MC3T3-E1 preosteoblasts. This dual-modality strategy may inform scaffold design in bone tissue engineering.

背景：镁（Mg）和光生物调节（PBM）分别被报道促进骨生成，但它们的联合作用尚不清楚。方法：制备mg条件下的壳聚糖水凝胶（0、20、50 mol%），分别在近红外PBM （830 nm, 5 J/cm²）和不含PBM的MC3T3-E1成骨前细胞中应用条件培养基。评估细胞活力、迁移和钙沉积（每组n=3个生物重复）。结果：高Mg降低了细胞迁移和矿化，而PBM显著增强了钙沉积，在早期时间点部分恢复了细胞活力（p < 0.05）。在20 mol% Mg与PBM联合时，观察到显著的协同效应，特别是在特定的时间点，表明条件依赖而不是统一的最佳反应。结论：mg条件水凝胶与PBM联合作用可增强MC3T3-E1成骨前细胞的成骨反应。这种双模态策略可以为骨组织工程中的支架设计提供信息。

{"title":"Synergistic effects of magnesium-conditioned chitosan hydrogels and photobiomodulation on MC3T3-E1 preosteoblast function","authors":"Hao-Hsuan Chiu , Pei-Chun Wong , Ying-Chun Chen","doi":"10.1016/j.pdpdt.2025.105307","DOIUrl":"10.1016/j.pdpdt.2025.105307","url":null,"abstract":"<div><h3>Background</h3><div>Magnesium (Mg) and photobiomodulation (PBM) have independently been reported to promote osteogenesis, but their combined effects remain unclear.</div></div><div><h3>Methods</h3><div>Mg-conditioned chitosan hygrogels (0,20, and 50 mol%) were prepared, and conditioned media were applied to MC3T3-E1 preosteoblasts with or without near-infrared PBM (830 nm, 5 J/cm²). Cell viability, migration, and calcium deposition were assessed (<em>n</em> = 3 biological replicates per group).</div></div><div><h3>Results</h3><div>High Mg reduced cell migration and mineralization, whereas PBM significantly enhanced calcium deposition and partially restored viability at early time points (<em>p</em> < 0.05). A notable synergistic effect was observed at 20 mol% Mg combined with PBM, particularly at specific time points, indicating a condition-dependent rather than uniformly optimal response.</div></div><div><h3>Conclusion</h3><div>The combination of Mg-conditioned hydrogels and PBM enhanced osteogenic responses in MC3T3-E1 preosteoblasts. This dual-modality strategy may inform scaffold design in bone tissue engineering.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105307"},"PeriodicalIF":2.6,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-targeted photodynamic therapy: A patented drug delivery system for total urethral condylomata acuminata 深度靶向光动力疗法：全尿道尖锐湿疣的专利给药系统。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-05 DOI: 10.1016/j.pdpdt.2025.105306

Junpeng Li , Jing Shen , Hui Liu , Shujiao Li , Xiaoming Peng , Yang Yang , Meinian Xu , Kang Zeng

Background

Treating total urethral condyloma acuminata (CA) remains challenging. Although 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) is a recommended first-line treatment for mucosal CA, conventional drug delivery fails to cover deep urethral lesions, often leading to recurrence.

Objective

To evaluate a novel self-developed drug delivery system designed to improve deep drug administration for 5-ALA-PDT in total urethral CA, aiming to enhance efficacy and reduce recurrence.

Methods

The system utilizes a specialized design to deliver 5-ALA to deep urethral areas. A representative case involved a patient with recurrent urethral CA (12 cm from meatus) after multiple laser and traditional PDT treatments. He received eight 5-ALA-PDT sessions with the new system.

Results

The system effectively delivered 5-ALA to deep lesions. The patient achieved virological clearance (undetectable HPV DNA) at 6 months, sustained through 8-month follow-up, with significant symptom improvement.

Conclusion

This novel delivery system enables precise 5-ALA administration to deep urethral lesions and latent HPV zones, improving treatment completeness and clinical outcomes for total urethral CA.

背景：治疗全尿道尖锐湿疣（CA）仍然具有挑战性。虽然5-氨基乙酰丙酸光动力疗法（5-ALA-PDT）是粘膜CA的一线推荐治疗方法，但传统的药物传递不能覆盖尿道深部病变，经常导致复发。目的：评价自主研发的新型给药系统，改善全尿道CA 5-ALA-PDT的深部给药，提高疗效，减少复发。方法：该系统采用特殊设计将5-ALA输送至尿道深部。一例典型病例是在多次激光和传统PDT治疗后复发性尿道CA（距离尿道道12cm）。他接受了8次新系统的5-ALA-PDT治疗。结果：该系统有效地将5-ALA输送到深部病变。患者在6个月时达到病毒学清除（未检测到HPV DNA），持续8个月的随访，症状明显改善。结论：这种新型的给药系统能够将5-ALA精确给药到尿道深部病变和HPV潜伏区，提高了全尿道CA的治疗完整性和临床效果。

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引用次数: 0

The Long-term observation of the quick contrast sensitivity and its influencing factors after SMILE SMILE术后快速对比灵敏度的长期观察及其影响因素。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-05 DOI: 10.1016/j.pdpdt.2025.105309

Weijung Ten , Yangyi Huang , Yiyong Xian , Yuhao Ye , Xingtao Zhou , Jing Zhao

Purpose

This study investigates the long-term impact of Small Incision Lenticule Extraction (SMILE) on quantitative contrast sensitivity (qCSF) and its determinants.

Materials and Methods

The research involved 80 eyes (mean spherical equivalent -6.10±1.95 D), including 40 highly myopic eyes. Seven years post-surgery, assessments included manifest refraction, axial length, corneal topography, and qCSF. Tangential curvature difference maps measured decentration and effective optical zone (EOZ). Statistical analysis explored correlations between qCSF metrics and ocular parameters.

Results

SMILE surgeries were uncomplicated. Safety and efficacy indices were 0.89±0.21 and 1.11±0.11, respectively. Significant correlations existed between cylindrical refraction (CR), residual CR, and qCSF [CR: AULCSF (r=0.061, p=0.010), CSF acuity (r=1.717, p=0.010); residual CR: AULCSF (r=-0.174, p=0.004), CSF acuity (r=-6.271, p<0.001)]. Subgroup analysis showed enhanced contrast sensitivity with lower ablation. Higher initial CR and lower residual CR correlated with superior qCSF. Long-term decentration negatively impacted qCSF in high myopia. EOZ in low-middle myopia differed significantly in qCSF metrics.

Conclusion

SMILE demonstrated excellent 7-year outcomes. In the low-to-moderate myopia group, all eyes (100 %) achieved UDVA of 20/25 or better, and postoperative astigmatism was within ±0.50 D. In the high myopia group, 72.5 % achieved UDVA ≥20/25. Greater preservation of corneal thickness was associated with better postoperative contrast sensitivity and visual quality, whereas residual astigmatism and minor decentration were linked to slightly reduced long-term outcomes

目的：探讨小切口透镜提取术（SMILE）对定量对比灵敏度（qCSF）的长期影响及其影响因素。材料与方法：研究对象为80只眼（平均球面等效-6.10±1.95 D），其中高度近视眼40只。术后7年，评估包括明显屈光、眼轴长度、角膜地形图和qCSF。切向曲率差映射测量的分散和有效光学区（EOZ）。统计分析探讨了qCSF指标与眼部参数之间的相关性。结果：SMILE手术操作简单。安全性和有效性指标分别为0.89±0.21和1.11±0.11。柱形折射（CR）、残差CR与qCSF [CR: AULCSF （r=0.061, p=0.010）、CSF敏锐度（r=1.717, p=0.010）存在显著相关性；剩余CR: AULCSF (r=-0.174, p=0.004)， CSF敏锐度（r=-6.271, p）。结论：SMILE具有良好的7年预后。低中度近视组所有眼（100%）UDVA达到20/25及以上，术后散光在±0.50 d以内。高度近视组72.5%的眼UDVA≥20/25。更好的角膜厚度保存与更好的术后对比敏感度和视觉质量相关，而残留的散光和轻微的分散与稍微降低的长期预后相关。

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引用次数: 0

SS-OCTA versus ICGA: a comparison of detection efficiency for large choroidal vein patterns in AMD patients SS-OCTA与ICGA：对AMD患者大脉络膜静脉形态检测效率的比较。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-04 DOI: 10.1016/j.pdpdt.2025.105303

Nianjia Wang , Xindi Liu , Jiayi Wu , Xintong Xiang , Yujia Gao , Liang Yao , Xin Wang

Purpose

To compare the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) and indocyanine green angiography (ICGA) in visualizing and classifying large choroidal vein topography, and to evaluate the association between specific venous patterns and pachychoroid spectrum disease (PSD)-associated macular neovascularization (MNV).

Methods

This retrospective cross-sectional study included 222 eyes from 160 patients with neovascular age-related macular degeneration (nAMD). All participants underwent both SS-OCTA and ICGA imaging. Choroidal venous patterns were classified into four types based on ICGA venous phase images: watershed, anastomotic, upper thicker, and lower thicker. SS-OCTA images were processed and analyzed using Fiji software. Diagnostic agreement between modalities was assessed using Cohen’s Kappa. Logistic regression was used to evaluate the association between venous patterns and disease subtypes.

Results

SS-OCTA and ICGA showed almost perfect agreement in classifying choroidal venous patterns in discernible cases (unweighted Kappa = 0.978). Among 77 eyes where ICGA failed to provide a clear classification, SS-OCTA achieved a definitive diagnosis in 87.0 % (P < 0.001), with the anastomotic type being the most common. Furthermore, the watershed pattern was significantly more prevalent in non-PCV nAMD compared to PCV (29.8 % vs. 12.1 %, p = 0.002), suggesting distinct choroidal venous backgrounds between these subtypes.

Conclusion

SS-OCTA provides a reliable, non-invasive alternative to ICGA for visualizing and classifying large choroidal veins, with superior performance in cases obscured by hemorrhage or leakage. The distinct distribution of venous patterns across nAMD subtypes highlights the potential role of choroidal venous architecture in disease phenotyping and pathogenesis.

目的：比较扫描源光学相干断层血管造影（SS-OCTA）和吲哚菁绿血管造影（ICGA）对大脉络膜静脉形态的可视化和分类效果，并评价特定静脉形态与厚脉络膜谱病（PSD）相关黄斑新生血管（MNV）的关系。方法：回顾性横断面研究纳入160例新生血管性年龄相关性黄斑变性（nAMD）患者222只眼。所有参与者均行SS-OCTA和ICGA成像。基于ICGA静脉相图像将脉络膜静脉形态分为分水岭型、吻合口型、上厚型和下厚型四种。使用Fiji软件对SS-OCTA图像进行处理和分析。采用Cohen’s Kappa评估不同诊断模式的一致性。采用Logistic回归评估静脉形态与疾病亚型之间的关系。结果：SS-OCTA与ICGA对可识别病例脉络膜静脉形态的分类几乎完全一致（未加权Kappa = 0.978）。在ICGA不能提供明确分类的77只眼中，SS-OCTA获得明确诊断的比例为87.0% (P < 0.001)，其中吻合型最常见。此外，与PCV相比，分水岭模式在非PCV nAMD中更为普遍（29.8% vs. 12.1%, p = 0.002），表明这些亚型之间脉络膜静脉背景不同。结论：SS-OCTA为大脉络膜静脉的显像和分类提供了一种可靠的、无创的替代方法，在出血或渗漏模糊的情况下具有更好的表现。静脉模式在nAMD亚型中的独特分布突出了脉络膜静脉结构在疾病表型和发病机制中的潜在作用。

{"title":"SS-OCTA versus ICGA: a comparison of detection efficiency for large choroidal vein patterns in AMD patients","authors":"Nianjia Wang , Xindi Liu , Jiayi Wu , Xintong Xiang , Yujia Gao , Liang Yao , Xin Wang","doi":"10.1016/j.pdpdt.2025.105303","DOIUrl":"10.1016/j.pdpdt.2025.105303","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) and indocyanine green angiography (ICGA) in visualizing and classifying large choroidal vein topography, and to evaluate the association between specific venous patterns and pachychoroid spectrum disease (PSD)-associated macular neovascularization (MNV).</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study included 222 eyes from 160 patients with neovascular age-related macular degeneration (nAMD). All participants underwent both SS-OCTA and ICGA imaging. Choroidal venous patterns were classified into four types based on ICGA venous phase images: watershed, anastomotic, upper thicker, and lower thicker. SS-OCTA images were processed and analyzed using Fiji software. Diagnostic agreement between modalities was assessed using Cohen’s Kappa. Logistic regression was used to evaluate the association between venous patterns and disease subtypes.</div></div><div><h3>Results</h3><div>SS-OCTA and ICGA showed almost perfect agreement in classifying choroidal venous patterns in discernible cases (unweighted Kappa = 0.978). Among 77 eyes where ICGA failed to provide a clear classification, SS-OCTA achieved a definitive diagnosis in 87.0 % (P < 0.001), with the anastomotic type being the most common. Furthermore, the watershed pattern was significantly more prevalent in non-PCV nAMD compared to PCV (29.8 % vs. 12.1 %, p = 0.002), suggesting distinct choroidal venous backgrounds between these subtypes.</div></div><div><h3>Conclusion</h3><div>SS-OCTA provides a reliable, non-invasive alternative to ICGA for visualizing and classifying large choroidal veins, with superior performance in cases obscured by hemorrhage or leakage. The distinct distribution of venous patterns across nAMD subtypes highlights the potential role of choroidal venous architecture in disease phenotyping and pathogenesis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105303"},"PeriodicalIF":2.6,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjunctive laser-based antimicrobial photodynamic therapy using methylene blue for refractory feline sporotrichosis 亚甲蓝辅助激光抗菌光动力治疗难治性猫孢子菌病。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-04 DOI: 10.1016/j.pdpdt.2025.105304

Mariana Lucy Mesquita Ramos , Anna Barreto Fernandes Figueiredo , Bruna Martins de França , Sandro Antonio Pereira , Marcel Guimarães Martins , Isabella Dib Ferreira Gremião

Feline sporotrichosis, a potentially zoonotic fungal infection caused by Sporothrix spp., represents a therapeutic challenge, especially in refractory cases. This report describes two cases that presented with refractory cutaneous lesions to conventional systemic treatment. Both cats were initially treated with a combination of itraconazole and potassium iodide for a prolonged period, resulting only in partial improvement and persistence of cutaneous lesions. Due to the lack of complete response, antimicrobial photodynamic therapy (aPDT) was introduced as an adjuvant treatment. The protocol involved multiple sessions of aPDT using methylene blue as photosensitizer, while conventional therapy was maintained. The first cat achieved complete clinical cure after 11 sessions and the second after 10 sessions. The successful outcome in these cases demonstrates the potential of aPDT as a promising adjuvant technique in the treatment of refractory feline sporotrichosis.

猫孢子菌病是由孢子丝杆菌引起的一种潜在的人畜共患真菌感染，是一种治疗挑战，特别是在难治性病例中。本报告描述了两例难治性皮肤病变的常规全身治疗。两只猫最初使用伊曲康唑和碘化钾长期联合治疗，结果仅部分改善，皮肤病变持续存在。由于缺乏完全缓解，抗菌光动力疗法（aPDT）被引入作为辅助治疗。该方案包括多次使用亚甲基蓝作为光敏剂的aPDT，同时维持常规治疗。第一只猫在11次治疗后获得了完全的临床治愈，第二只猫在10次治疗后获得了完全的临床治愈。这些病例的成功结果表明，aPDT作为治疗难治性猫孢子虫病的一种有前途的辅助技术的潜力。

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引用次数: 0

Multimodal and 3D imaging presentation of the evolution of pressure-related CNV 压力相关CNV演变的多模态和三维成像表现。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-04 DOI: 10.1016/j.pdpdt.2025.105305

Nianjia Wang , Xindi Liu , Jiayi Wu , Xintong Xiang , Yujia Gao , Liang Yao , Shaobo Zhang

This study reports a unique case that visually demonstrates the six-year evolution of a pressure-related choroidal neovascularization (CNV) using multimodal image registration and three-dimensional (3D) reconstruction. A 65-year-old female with neovascular age-related macular degeneration received 33 anti-VEGF injections over six years but experienced continued vision decline. Through precise registration of indocyanine green angiography, and optical coherence tomography angiography images, combined with 3D modeling of swept-source OCTA volume data. We found that the main trunk of this large, tree-like type II CNV originated from an abnormally dilated great vein, which exhibited an anastomosis with an accompanying great vein. Furthermore, the 3D reconstruction viewed from the scleral side revealed that this vein was closely opposed to and shared a shunt branch with an underlying choroidal great artery. The CNV appeared to function as a "pressure-relief valve," sprouting from the venous trunk to alleviate pressure. This case underscores the critical role of deep multimodal imaging integration in tracing CNV origins and reveals that some anti-VEGF-resistant CNVs may represent hemodynamic compensatory disorders secondary to pre-existing large vessel structural abnormalities, rather than purely neovascular diseases.

本研究报告了一个独特的病例，使用多模态图像配准和三维（3D）重建，直观地展示了压力相关脉络膜新生血管（CNV）的六年演变。一名患有新生血管性年龄相关性黄斑变性的65岁女性患者在6年内接受了33次抗vegf注射，但视力持续下降。通过对吲哚菁绿血管造影、光学相干断层成像血管造影图像进行精确配准，结合三维建模得到扫描源OCTA体数据。我们发现这个大的树状II型CNV的主干起源于一个异常扩张的大静脉，它与伴随的大静脉吻合。此外，从巩膜侧的3D重建显示，该静脉与脉络膜大动脉紧密相对，并与其下的脉络膜大动脉共用一条分流分支。CNV似乎起着“减压阀”的作用，从静脉主干萌发以减轻压力。该病例强调了深度多模态成像整合在追踪CNV起源中的关键作用，并揭示了一些抗vegf -resistant CNV可能代表继发于先前存在的大血管结构异常的血流动力学代偿障碍，而不是纯粹的新生血管疾病。

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引用次数: 0