Photodiagnosis and Photodynamic Therapy最新文献_第2页

Effects of laughter exercise on intraocular pressure, Schlemm’s canal and chorioretinal parameters in healthy adults 笑运动对健康成人眼压、施莱姆管和视网膜参数的影响。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2026-01-08 DOI: 10.1016/j.pdpdt.2026.105339

Yunkao Zeng , Kityee Ng , Wanni Chen, Yue Zhou, Yan Mao, Jinfei Lu, Junming Wang

Purpose

This study investigated the effects of laughter exercise on IOP, anterior and posterior segment parameters in healthy adults.

Methods

This study involved 23 healthy adults who underwent baseline and post-intervention measurements of IOP and ocular structures. Using swept-source OCT(SS-OCT), we quantified Schlemm’s canal area (SCAR) and trabecular meshwork thickness across four quadrants, and assessed posterior segment parameters with a 24 × 20 mm ultra-widefield protocol. Measurements were repeated at 1, 15, 30, and 60 min after a 5-minute standardized laughter exercise to analyze longitudinal changes and IOP correlations.

Results

IOP significantly decreased at 1, 15, and 30 min after laughter exercise (all p < 0.01), then recovered at 60 min(p = 0.131). The nasal SCAR significantly enlarged at 15 min(p < 0.001) and 30 min post-exercise(p = 0.004). Temporal SCAR only showed significant increase at 1 min post-exercise(p = 0.025). The superior SCAR significantly enlarged at 1 min(p = 0.008) and 30 min(p = 0.041) post-exercise. Inferior SCAR remained stable throughout the study period(p = 0.204). The trabecular meshwork thickness in all 4 quadrants only exhibited significant increase at 1 min post-exercise(all p < 0.01). No significant changes in chorioretinal parameters were noted (all p > 0.05). In the multivariate model, retinal superficial capillary plexus vessel density positively corelated with IOP (β=4.00, p = 0.009), whereas nasal SCAR demonstrated a negative correlation (β=-2.40, p = 0.003).

Conclusions

The anterior and posterior segment demonstrated distinct responses to a standardized laughter exercise. The IOP changes are associated with the expansion of Schlemm’s canal. Further research is warranted to determine the efficacy of laughter exercise as a non-pharmacological adjunct for IOP control.

目的：探讨大笑运动对健康成人IOP、前、后节参数的影响。方法：本研究涉及23名健康成人，他们接受了基线和干预后的IOP和眼部结构测量。使用扫描源OCT(SS-OCT)，我们量化了Schlemm管面积（SCAR）和四个象限的小梁网厚度，并使用24 × 20 mm超宽视场方案评估了后段参数。在5分钟的标准笑练习后的1分钟、15分钟、30分钟和60分钟重复测量，以分析纵向变化和眼内压相关性。结果：IOP在笑声运动后1、15、30分钟显著降低（均p0.05）。在多元模型中，视网膜浅毛细血管丛血管密度与IOP呈正相关（β=4.00, p=0.009），而鼻腔SCAR呈负相关（β=-2.40, p=0.003）。结论：前段和后段对标准化的笑练习表现出不同的反应。眼压变化与施勒姆氏管扩张有关。进一步的研究是有必要的，以确定笑运动作为一种非药物辅助控制眼内压的功效。

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引用次数: 0

Does metabolic dysfunction-associated steatotic liver disease affect the ocular circulation? 代谢功能障碍相关的脂肪变性肝病会影响眼循环吗？

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2026-01-08 DOI: 10.1016/j.pdpdt.2026.105334

Nihat Aydın , Mustafa Capraz , Burcu Akman , Seyma Nur Altınok , Melek Tufek , Caner Kara

Purpose

To evaluate the choroidal thickness (CT), central retinal artery (CRA), ophthalmic artery (OA), internal carotid artery (ICA) and common carotid artery (CCA) hemodynamic parameters and the carotid intima-media thickness (CIMT) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods

This prospective study included 98 MASLD patients and 30 healthy controls. MASLD patients were classified into three stages via liver ultrasonography.

Results

CT was significantly decreased at all measured points in Stage 2 and Stage 3 MASLD patients versus controls and at subfoveal and nasal (500–1000-1500 µm) points in Stage 3 compared to Stage 1(all p < 0.05). A significant relationship was observed between CT and age, MASLD stage, and GGT levels. OA peak sistolik velocity (PSV), ICA PSV, enddiastolic velocity (EDV), and CCA EDV values were significantly lower in Stage 3 compared to the control group and Stage 1 while the ICA PSV and CCA EDV values were significantly lower in Stage 3 compared to Stage 2 (all p < 0.05). The CCA resistive index (RI) and pulsatile index (PI) were significantly higher in Stage 3 than in the control group and Stage 1 as with the CCA PI value in Stage 3 compared to Stage 2 (p = 0.026, p = 0.035, p = 0.011, p = 0.014, p = 0.022, respectively). CIMT was significantly higher in Stage 3 than in controls (p = 0.005).

Conclusions

MASLD affects ocular vascular structures and may be associated with an increased risk of ocular pathologies.

目的：评价代谢功能障碍相关性脂肪变性肝病（MASLD）患者脉络膜厚度（CT）、视网膜中央动脉（CRA）、眼动脉（OA）、颈内动脉（ICA）和颈总动脉（CCA）血流动力学参数及颈动脉内膜-中膜厚度（CIMT）。方法：本前瞻性研究包括98例MASLD患者和30例健康对照。通过肝脏超声检查将MASLD患者分为三个阶段。结果：与对照组相比，2期和3期MASLD患者的所有测点CT均显著降低，3期患者的中央凹下和鼻（500-1000-1500µm）测点CT与1期相比均显著降低（均p < 0.05）。CT与年龄、MASLD分期和GGT水平有显著关系。3期患者OA峰值静压速率（PSV）、ICA PSV、舒张末期速度（EDV）、CCA EDV值均显著低于对照组和1期，3期患者ICA PSV、CCA EDV值均显著低于2期（p < 0.05）。CCA电阻指数(RI)和搏动性指数(PI)在第三阶段明显高于对照组和第一阶段与CCAπ值相比,第三阶段第二阶段(p = 0.026,p = 0.035,p = 0.011,p = 0.014,p = 0.022,分别)。第三期患者CIMT显著高于对照组（p = 0.005）。结论：MASLD影响眼部血管结构，可能与眼部病变风险增加有关。

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引用次数: 0

Axial and choroidal changes as key predictors of myopia control in red-light therapy: Evidence from machine learning models 眼轴和脉络膜的变化是红光治疗中近视控制的关键预测因素：来自机器学习模型的证据。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2026-01-07 DOI: 10.1016/j.pdpdt.2026.105342

Xiaoxue Hu , Zixun Wang , Rui Li , Boxuan Sun , Dingkang Wang , Hui Zong , Xiaoling Zhang , Ruihua Wei , Hong Jie

Background

Repeated low-level red-light (RLRL) therapy has emerged as a promising non-invasive intervention for myopia control. However, the predictive factors underlying its efficacy remain insufficiently explored.

Methods

This multicenter cohort study included 538 pediatric patients who underwent RLRL treatment with a minimum follow-up of one year. Baseline ocular parameters and dynamic changes in axial length (AL) and choroidal thickness (ChT) over three months were collected. Multiple feature selection approaches—LASSO regression, Boruta, recursive elimination, and multivariate regression—were applied. Seven machine learning algorithms were trained, and their performance was evaluated using the area under the curve (AUC), sensitivity, specificity, and F1 score. SHAP and LIME analyses were utilized for interpretability.

Results

Logistic regression and gradient boosting models demonstrated the highest discriminative ability. XGBoost achieved optimal performance (AUC: 0.90–0.92; accuracy: 87.7–88.2 %; F1 score: 0.72–0.86). Across one- and two-year prediction models, six stable predictors were identified: age, baseline AL, anterior chamber depth (ACD), RNFL thickness at the temporal inferior quadrant (TI), ChangeAL, and ChangeChT. SHAP analysis revealed that ChangeAL was the dominant short-term predictor, whereas ChangeChT was most influential for long-term outcomes. Older age and greater choroidal thickening were consistently associated with a protective effect against myopia progression.

Conclusions

We developed and validated an interpretable machine learning model that accurately predicts short- and long-term outcomes of RLRL therapy in children. ChangeAL and ChangeChT serve as key dynamic biomarkers for treatment monitoring. These findings provide a foundation for personalized clinical decision-making in myopia management.

背景：重复低水平红灯（RLRL）治疗已成为一种很有前途的非侵入性近视控制干预措施。然而，其有效性的预测因素仍未得到充分探讨。方法：这项多中心队列研究包括538例接受RLRL治疗的儿童患者，随访时间至少为1年。收集三个月的基线眼参数和眼轴长度（AL）和脉络膜厚度（ChT）的动态变化。采用lasso回归、Boruta回归、递归消除和多元回归等多种特征选择方法。对7种机器学习算法进行了训练，并使用曲线下面积（AUC）、灵敏度、特异性和F1评分来评估它们的性能。采用SHAP和LIME分析进行可解释性分析。结果：Logistic回归模型和梯度增强模型的判别能力最强。XGBoost获得了最佳性能（AUC: 0.90-0.92；准确率：87.7-88.2%；F1分数：0.72-0.86）。在1年和2年的预测模型中，确定了6个稳定的预测因子：年龄、基线AL、前房深度（ACD）、颞下象限RNFL厚度（TI）、ChangeAL和ChangeChT。SHAP分析显示，ChangeAL是主要的短期预测因子，而ChangeChT对长期结果影响最大。年龄越大和脉络膜增厚越大始终与防止近视进展的保护作用有关。结论：我们开发并验证了一个可解释的机器学习模型，该模型可以准确预测儿童RLRL治疗的短期和长期结果。ChangeAL和ChangeChT是治疗监测的关键动态生物标志物。这些发现为近视治疗的个性化临床决策提供了依据。

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引用次数: 0

The impact of BMI on myopia incidence in Chinese children BMI对中国儿童近视发生率的影响

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2026-01-07 DOI: 10.1016/j.pdpdt.2026.105343

Xueyang Yan , Liuliu Shi , Guiwen Si , Anran Gu , Yali Fan , Min Li

Purpose

This research explored the relationship between body mass index (BMI) and myopia in China.

Design

Retrospective cohort study.

Methods

This retrospective study included 9054 participants from Bengbu, China, from the years 2022 to 2024. The data included age, gender, spherical equivalent (SE), weight, height, body mass index (BMI), and the changes in these parameters measured between 2022 and 2024. Regression analysis was used to analyze the relationships between weight, height, BMI, and SE.

Results

The findings showed that the incidence of moderate and high myopia rises with age. Specifically, the measured prevalence rates across different years were: moderate myopia - 10.1% (2022), 10.7% (2023), 20.6% (2024); high myopia - 2.3% (2022), 2.4% (2023), 4.1% (2024). As height, weight, and BMI increase, the ratio of moderate and high myopia rises in 2022 to 2024 (P < 0.001). Participants with a height greater than 150 cm, a weight greater than 60 kg, and a BMI greater than 25.0 experienced a 12%, 32%, and 13% increased risk of myopia, respectively (OR 1.12; p = 0.013, OR 1.32; p = 0.028, OR 1.13; p = 0.021). The most significant factors negatively associated with SE were age (B = -0.303 in 2022, -0.312 in 2023, -0.321 in 2024, P < 0.001) and BMI (B = -0.204 in 2022, -0.194 in 2023, -0.291 in 2024, P < 0.001). The change in SE is associated with changes in height and BMI, but not with change in weight (P > 0.05).

Conclusions

The incidence of myopia and the severity of the condition in this group of Chinese children did increase annually between 2022 and 2024. Weight, height, and BMI are associated with the occurrence of myopia. Changes in height and BMI correlate with alterations in SE.

目的：探讨体质指数（BMI）与近视的关系。设计：回顾性队列研究。方法：本回顾性研究包括来自中国蚌埠的9,054名参与者，时间为2022年至2024年。这些数据包括年龄、性别、球形当量（SE）、体重、身高、身体质量指数（BMI），以及这些参数在2022年至2024年间的变化。采用回归分析方法分析体重、身高、BMI与SE之间的关系。结果：中、高度近视的发生率随年龄增长而上升。具体而言，不同年份的测量患病率为：中度近视- 10.1%（2022年），10.7%（2023年），20.6%（2024年）；高度近视,2.3%(2022),2.4%(2023),4.1%(2024)。随着身高、体重和BMI的增加，2022 ~ 2024年中度和高度近视的比例呈上升趋势（P < 0.05）。结论：在2022年至2024年期间，这组中国儿童的近视发病率和近视严重程度确实逐年增加。体重、身高和体重指数与近视的发生有关。身高和BMI的变化与SE的变化相关。

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引用次数: 0

Enhanced in vitro photodynamic therapy for triple-negative breast cancer by pheophorbide a-encapsulated chitosan-tripolyphosphate nanoparticles 磷包封壳聚糖-三聚磷酸纳米颗粒增强三阴性乳腺癌的体外光动力治疗。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-24 DOI: 10.1016/j.pdpdt.2025.105332

Wen-Yao Yin , Zih-You Lin , Mei-Ying Wang , Dhivyabharathi Balakrishnan , Cheng-I Lee

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Current treatment strategies typically involve surgical resection and chemotherapy, both of which are often associated with significant adverse effects. As an alternative, photodynamic therapy (PDT) offers a minimally invasive approach to selectively target tumor cells. In this work, PDT was evaluated using pheophorbide a (Pa) as a photosensitizer. To enhance its therapeutic efficacy, Pa was encapsulated in ionically crosslinked chitosan/tripolyphosphate (TPP) nanoparticles. Furthermore, nanoparticles synthesized from chitosan subjected to various pre-treatments were compared in terms of their physicochemical properties. The optimized Pa-loaded chitosan/TPP nanoparticles (PaCNPs) exhibited enhanced singlet oxygen (¹O₂) generation upon photoactivation of Pa. Cellular uptake and intracellular distribution of Pa were extensively examined in MDA-MB-453 and MDA-MB-231 cell lines. Notably, nanoparticle encapsulation resulted in a fourfold reduction in IC₅₀ in MDA-MB-231 cells, whereas no significant change was observed in MDA-MB-453 cells. The distinct responses of these cell lines to PaCNPs-mediated PDT in are further discussed.

三阴性乳腺癌（TNBC）是一种高度侵袭性的乳腺癌亚型。目前的治疗策略通常包括手术切除和化疗，这两种方法通常都伴有明显的不良反应。作为替代方案，光动力疗法（PDT）提供了一种选择性靶向肿瘤细胞的微创方法。在这项工作中，PDT被评价使用磷化物a （Pa）作为光敏剂。为了提高其治疗效果，将Pa包被在离子交联壳聚糖/三聚磷酸（TPP）纳米颗粒中。此外，还比较了壳聚糖经不同预处理后合成的纳米颗粒的理化性质。优化后的负载Pa的壳聚糖/TPP纳米颗粒（PaCNPs）在Pa光活化下表现出增强的单线态氧（1O2）生成。在MDA-MB-453和MDA-MB-231细胞系中广泛检测了Pa的细胞摄取和细胞内分布。值得注意的是，纳米颗粒包封导致MDA-MB-231细胞的IC50降低了四倍，而MDA-MB-453细胞的IC50没有显著变化。进一步讨论了这些细胞系对pacnps介导的PDT的不同反应。

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引用次数: 0

Monte Carlo-based estimation of NIR-PDT efficacy with and without breast compression in early-stage breast cancer 基于蒙特卡罗的NIR-PDT在早期乳腺癌中有无乳房压迫的疗效评估。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-24 DOI: 10.1016/j.pdpdt.2025.105330

Yugo Minegishi, Yasutomo Nomura

Introduction

Near-infrared photodynamic therapy (NIR-PDT) for early-stage breast cancer has attracted attention and it suggests that the depth of the tumor from the skin surface significantly affects treatment efficacy, with shallower tumors responding more effectively to therapy. Therefore, compressing the breast, as is done during mammography, may improve therapeutic outcomes by reducing tumor depth. In this study, we investigated the effectiveness of breast compression in NIR-PDT for early-stage breast cancer using Monte Carlo simulations.

Methods

We evaluated the impact of breast compression on the effectiveness of NIR-PDT for early-stage breast cancer through Monte Carlo simulations. Sixty pairs of digital breast phantoms representing uncompressed and compressed states were generated, and spherical tumors with a 7 mm diameter were embedded under appropriate conditions in 15 of these pairs. The propagation of excitation light at an intensity of 330 mW/cm², a level considered safe for skin tissue, was then analyzed. Based on the computed excitation fluence, the corresponding amount of singlet oxygen produced was estimated to assess NIR-PDT efficacy.

Results

The simulations indicated that breast compression substantially reduced tumor depth, with an average decrease of 5 mm across the 15 pairs. Consequently, the number of irradiation sessions required for complete treatment was reduced by an average of 19. In 8 of the 15 phantoms, the number of treatment irradiation cycles was reduced to five or fewer, suggesting clinical feasibility.

Conclusion

These results demonstrate that applying appropriate breast compression can enhance the therapeutic performance of NIR-PDT for early-stage breast cancer.

导读：近红外光动力治疗（NIR-PDT）对早期乳腺癌的治疗引起了人们的关注，研究表明肿瘤距离皮肤表面的深度显著影响治疗效果，较浅的肿瘤对治疗的反应更有效。因此，在乳房x光检查中压迫乳房可以通过减少肿瘤深度来改善治疗效果。在这项研究中，我们使用蒙特卡罗模拟研究了乳房压迫在NIR-PDT治疗早期乳腺癌中的有效性。方法：我们通过蒙特卡罗模拟评估乳房压迫对NIR-PDT治疗早期乳腺癌有效性的影响。生成60对代表未压缩和压缩状态的数字乳房幻象，并在适当条件下在其中15对中嵌入直径为7 mm的球形肿瘤。然后分析了激发光在330 mW/cm²强度下的传播，该强度被认为对皮肤组织是安全的。根据计算的激发通量，估计相应的单线态氧产生量，以评估NIR-PDT的有效性。结果：模拟表明，乳房压缩大大减少了肿瘤深度，在15对中平均减少了5mm。因此，完成治疗所需的照射次数平均减少了19次。在15例幻影中，有8例治疗照射周期减少到5次或更少，表明临床可行性。结论：适当的乳腺压迫可提高NIR-PDT对早期乳腺癌的治疗效果。

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引用次数: 0

Enhanced reactive oxygen species generation using photonic platforms containing polyethylene glycol hydrogel doped with a photosensitizer for photodynamic therapy 利用掺杂光敏剂的聚乙二醇水凝胶光子平台增强活性氧的生成。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-24 DOI: 10.1016/j.pdpdt.2025.105331

H. Rahimi

This work presents the design and analysis of a symmetric one-dimensional photonic crystal incorporating a polyethylene glycol hydrogel doped with porphyrin derivatives (TBPP, TMPP, TPP, TCPP, and TAPP) for enhancing reactive oxygen species generation in photodynamic therapy. The photonic structure is engineered such that the defect resonance mode overlaps the absorption Q-band of porphyrins. Simulation results show that increasing the intrinsic refractive index of porphyrin systematically red-shifts the resonance wavelength from 715.27 nm (TBPP) to 716.58 nm (TAPP). Among all derivatives, TCPP and TAPP show the best optical metrics such as the quality factor, detection limit, and figure of merit. Also, the electric field distribution analysis reveals intense light localization, up to 150-fold enhancement within the defect region. The supposed biosensor exhibit high quality factors (nearly 4700), narrow linewidths (Δλ_FWHM=0.152 nm), high sensitivity (83–88 nm·RIU⁻¹), low detection limits (1.8×10⁻³ RIU), and large figures of merit (546–580). Our study introduces a photonic platform that acts as an optical booster which concentrates light to enhance the activation efficiency of photosensitizers at the defect site.

本研究提出了一种对称一维光子晶体的设计和分析，该晶体采用掺有卟啉衍生物（TBPP、TMPP、TPP、TCPP和TAPP）的聚乙二醇水凝胶，以增强光动力治疗中活性氧的产生。设计的光子结构使得缺陷共振模式与卟啉的吸收q带重叠。仿真结果表明，增加卟啉的本征折射率可以使共振波长从715.27 nm （TBPP）红移到716.58 nm （TAPP）。在所有衍生品中，TCPP和TAPP表现出最好的光学指标，如质量因子、检测限和优点值。此外，电场分布分析显示了强光局部化，在缺陷区域内增强高达150倍。假定的生物传感器具有高质量因子（近4700），窄线宽（ΔλFWHM=0.152 nm），高灵敏度（83-88 nm·RIU⁻），低检测限（1.8×10⁻³RIU）和大优点（546-580）。我们的研究引入了一种光子平台，它可以作为光学助推器，在缺陷部位集中光以提高光敏剂的激活效率。

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引用次数: 0

Association between ABO and Rh blood groups and choroidal structural parameters in adult population ABO和Rh血型与成人脉络膜结构参数的关系

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-23 DOI: 10.1016/j.pdpdt.2025.105328

Özkan Kocamış, Tülay Karacan Erşekerci, Kemal Örnek

Background

The ABO and Rh blood group systems have been associated with various systemic and ocular diseases. The choroid, as the most vascularized ocular structure, plays a critical role in retinal health. The choroidal vascularity index (CVI) has emerged as arobust metric for evaluating choroidal structure. This study aimed to investigate the association between ABO and Rh blood groups and choroidal structural parameters, including CVI, in a healthy adult population.

Methods

This prospective study included 164 healthy participants who underwent comprehensive ophthalmologic examination, including enhanced depth imaging optical coherence tomography (EDI-OCT). Subfoveal choroidal parameters—stromal area (SA), luminal area (LA), total choroidal area (TCA), and CVI—were measured using Image-J software. Participants were grouped according to ABO and Rh blood types. Statistical comparisons were conducted using Kruskal-Wallis, Mann-Whitney U, Chi- Square, and Spearman correlation tests.

Results

Among the 164 participants (55.5% female), blood type distributions were: A (36.6%), B (20.1%), AB (15.9%), and O (27.4%). Statistically significant differences were found between ABO blood groups for SA, LA, and TCA (p < 0.05). Blood group B exhibited significantly higher SA, LA, and TCA compared to other groups. However, CVI did not differ significantly among ABO or Rh groups (p > 0.05). No correlations were observed between age or axial length and choroidal parameters.

Conclusion

While SA, LA, and TCA values vary across ABO blood groups—particularly elevated in blood group B—CVI remains stable, suggesting a proportional expansion of stromal and vascular components. These findings imply a potential genetic influence of blood group antigens on choroidal morphology without affecting vascular density. Further large-scale, multiethnic studies are warranted to validate these associations.

背景：ABO和Rh血型系统与各种全身和眼部疾病有关。脉络膜作为血管最丰富的眼部结构，在视网膜健康中起着至关重要的作用。脉络膜血管指数（CVI）已成为评价脉络膜结构的重要指标。本研究旨在探讨健康成人人群中ABO和Rh血型与脉络膜结构参数（包括CVI）之间的关系。方法：本前瞻性研究纳入164名健康参与者，他们接受了全面的眼科检查，包括增强深度成像光学相干断层扫描（EDI-OCT）。使用Image-J软件测量中央凹下脉络膜参数-基质面积（SA）、腔面积（LA）、总脉络膜面积（TCA）和cvi。参与者根据ABO血型和Rh血型分组。采用Kruskal-Wallis、Mann-Whitney U、卡方检验和Spearman相关检验进行统计学比较。结果：164名参与者中，女性占55.5%，血型分布为：A型（36.6%）、B型（20.1%）、AB型（15.9%）、O型（27.4%）。SA、LA、TCA的ABO血型间差异有统计学意义（p < 0.05）。与其他组相比，B组的SA、LA和TCA明显升高。而CVI在ABO组和Rh组间差异无统计学意义（p < 0.05）。年龄或轴向长度与脉络膜参数之间没有相关性。结论：虽然SA、LA和TCA值在不同ABO血型之间存在差异，尤其是在b血型中升高，但cvi保持稳定，表明基质和血管成分呈比例扩张。这些发现暗示了血型抗原对脉络膜形态的潜在遗传影响，而不影响血管密度。进一步的大规模、多民族研究有必要验证这些关联。

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引用次数: 0

Photodynamic therapy used as an adjunct to endodontic retreatment 作为牙髓再治疗辅助手段的光动力疗法。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-23 DOI: 10.1016/j.pdpdt.2025.105333

Mariana Souza d'Afonseca , Carlos Wesley Lopes Brasil da Silva , Ana Luiza Gonzaga Zonca , Henrico Badaoui Strazzi-Sahyon , Luciano Tavares Angelo Cintra , Gustavo Sivieri-Araújo

引用次数: 0

Differences in epiretinal macrophage-like cells and associated retinochoroidal changes between multifocal choroiditis and punctate inner choroidopathy observed using widefield optical coherence tomography angiography 广角光学相干断层血管造影观察多灶性脉络膜炎和点状内脉络膜病视网膜外巨噬细胞样细胞及相关视网膜脉络膜改变的差异。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy

Pub Date : 2025-12-20 DOI: 10.1016/j.pdpdt.2025.105325

Ruijun Yang, Xiongze Zhang, Miaoling Li, Feng Wen

Purpose

To investigate the features of epiretinal macrophage-like cells (eMLC) and retinochoroidal parameters in multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC) by using widefield optical coherence tomography angiography (WF-OCTA).

Methods

This retrospective cross-sectional study included 16 eyes from 11 patients with MFC, 16 eyes from 13 patients with PIC, and 16 eyes from 16 matched healthy controls. The eMLC was semi-automatically segmented and quantified on en face optical coherence tomography (OCT) images, derived from a 3-μm slab on the inner limiting membrane. From the corresponding 24 × 20 mm retina scan area, retinochoroidal parameters were measured using WF-OCTA.

Results

Eyes with MFC exhibited a significantly greater number and density of eMLC compared with both eyes with PIC and healthy control eyes (all P < 0.05). Furthermore, compared to the PIC eyes, the MFC eyes demonstrated significantly greater thickness of the inner retinal layer, outer retinal layer, total retina, and choroid (all P < 0.05). Choroidal structural analysis revealed that both choroidal capillary density (CCD) and choroidal vessel volume (CVV) were also significantly higher in MFC eyes than in PIC and control eyes (all P < 0.05). In contrast, no significant differences were observed in any of the measured retinochoroidal parameters between the PIC and control eyes. While there was no significant difference in retinal thickness of typical lesion between the MFC and PIC groups, the choroidal thickness of typical lesion was markedly greater in patients with MFC (P < 0.05). Furthermore, a significant positive correlation was identified between eMLC density and RT within the MFC group. A subgroup analysis focusing on disease activity demonstrated that MFC eyes with active leakage on fundus fluorescein angiography (FFA) had significantly higher eMLC density, inner retinal thickness, total retinal thickness, choroidal thickness, and CVV than eyes without FFA leakage (P < 0.05 for all).

Conclusion

The MFC group demonstrated a significantly greater eMLC density, increased retinochoroidal thickness, and higher density of the choroidal vasculature compared to both the PIC and control groups, between which there were no significant differences. These findings indicate that MFC represents a diffuse, full-thickness retinochoroidal inflammatory process, in contrast to the more localized inflammation characteristic of PIC. Besides, the eMLC may serve as a non-invasive indicator for assessing the severity of fluorescein leakage and retinal inflammation in MFC, offering an objective tool for longitudinal monitoring.

目的：应用广角光学相干断层血管造影（WF-OCTA）研究多灶性脉络膜炎（MFC）和点状内脉络膜病（PIC）的视网膜前巨噬细胞样细胞（eMLC）特征和视网膜脉络膜参数。方法：本回顾性横断面研究包括来自11例MFC患者的16只眼睛，来自13例PIC患者的16只眼睛，以及来自16名匹配健康对照的16只眼睛。eMLC在表面光学相干断层扫描（OCT）图像上进行半自动分割和定量，该图像来自于内限定膜上的3 μm板。在相应的24 × 20 mm视网膜扫描区域，使用WF-OCTA测量视网膜脉络膜参数。结果：MFC组eMLC的数量和密度明显高于PIC组和健康对照组（P < 0.05）。此外，与PIC眼相比，MFC眼的视网膜内层厚度、视网膜外层厚度、视网膜总厚度和脉络膜厚度均显著增加（P < 0.05）。脉络膜结构分析显示，MFC眼脉络膜毛细血管密度（CCD）和脉络膜血管体积（CVV）均显著高于PIC眼（P < 0.05）。相比之下，在PIC和对照眼之间没有观察到任何测量的视网膜脉络膜参数的显着差异。MFC组与PIC组典型病变视网膜厚度差异无统计学意义，但MFC组典型病变脉络膜厚度明显大于PIC组（P < 0.05）。此外，在MFC组中，eMLC密度与RT之间存在显著的正相关。一项关注疾病活动性的亚组分析显示，眼底荧光素血管造影（FFA）显示活动性渗漏的MFC眼的eMLC密度、视网膜内厚度、视网膜总厚度、脉络膜厚度和CVV显著高于无FFA渗漏的眼（P < 0.05）。结论：与PIC组和对照组相比，MFC组eMLC密度显著增加，视网膜脉络膜厚度增加，脉络膜血管密度更高，两者之间无显著差异。这些结果表明，MFC是一种弥漫性的全层视网膜脉络膜炎症过程，而PIC的炎症特征更局限。此外，eMLC可作为评估MFC荧光素泄漏和视网膜炎症严重程度的无创指标，为纵向监测提供客观工具。

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