Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Efficacy of toric intraocular lens implantation in individuals with cataracts and asymmetric corneal astigmatism","authors":"Jiezheng Xue ,&nbsp;Anpeng Pan ,&nbsp;Xu Shao ,&nbsp;Xu Xu","doi":"10.1016/j.pdpdt.2025.104515","DOIUrl":"10.1016/j.pdpdt.2025.104515","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to evaluate the efficacy and safety of toric intraocular lens (IOL) implantation in individuals with cataracts and asymmetric corneal astigmatism and to assess their postoperative visual quality.</div></div><div><h3>Methods</h3><div>In this prospective case series, 26 eyes of individuals with cataracts and corneal astigmatism &gt; 0.75 diopters (D) and asymmetric central astigmatism as identified through corneal topography were examined at the Eye Hospital of Wenzhou Medical University, China. All participants underwent toric IOL implantation surgery at the hospital. The primary outcome measures included uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), residual astigmatism, prediction error, and the degree of IOL rotation.</div></div><div><h3>Results</h3><div>Both postoperative UCVA and BCVA improved significantly, with UCVA increasing from 0.70 (0.40, 0.93) to 0.018 (0.05, 0.30) logMAR, and BCVA improving from 0.50 (0.38, 0.70) to 0.00 (0.0, 0.10) logMAR (P &lt; 0.001). A strong positive correlation was observed between the preoperative predicted spherical equivalent and the postoperative actual spherical equivalent (= 0.7682), with prediction errors for the spherical equivalent within ± 1.00 D in all cases. Postoperative residual astigmatism was ≤ 1.00 D in 25 eyes (96%), and the mean degree of toric IOL rotation was 2.46° ± 2.08°. Objective assessments of visual quality showed that patients with asymmetric corneal astigmatism achieved better postoperative visual quality under miotic conditions (pupil diameter: 2 mm), with a significant decrease in visual quality as pupil diameter increased.</div></div><div><h3>Conclusion</h3><div>The results of this study demonstrated that toric IOL implantation surgery is an effective and safe treatment for selected individuals with cataracts and asymmetric corneal astigmatism. Preoperative predictions for spherical equivalent and residual astigmatism in these patients proved accurate and reliable, resulting in favorable visual outcomes and enhanced visual quality post-surgery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104515"},"PeriodicalIF":3.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of additional points in the 24-2C visual field test in pre-perimetric glaucoma","authors":"Gökhan Çelik ,&nbsp;Tuncay Karaçocuk ,&nbsp;Furkan Çiftci","doi":"10.1016/j.pdpdt.2025.104513","DOIUrl":"10.1016/j.pdpdt.2025.104513","url":null,"abstract":"<div><h3>Background</h3><div>Early detection and prevention of glaucoma progression are critical. However, studies of early visual field (VF) changes, particularly those using the 24-2C VF test, are limited. Evaluation of additional points in 2C may help identify glaucoma at an early stage, enabling timely intervention. Pre-perimetric glaucoma (PPG) is characterised by structural damage without noticeable VF loss in standard tests. Assessments of changes in retinal nerve fibre layer (RNFL) and macular ganglion cell complex (mGCC) thickness are valuable, but exploring how these structural changes are related to functional deficits is crucial.</div></div><div><h3>Objective</h3><div>This study focused on the average of the additional points in the 24-2C test to understand their correlation with structural measures in the PPG.</div></div><div><h3>Material and method</h3><div>This study included 59 patients with PPG and 36 healthy individuals. All the patients underwent peripapillary and macular optical coherence tomography (OCT) (Nidek RS-3000 Advance; Nidek, Japan). RNFL thickness was evaluated using peripapillary OCT, and mGCC thickness was evaluated using the macular OCT glaucoma module. The mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI), and average of additional points in the 2C (AAP-2C) were evaluated using the 24-2C SITA Faster VF Humphrey Field Analyser III Model 850 (HFAIII; Zeiss Meditec, Dublin, CA, USA). The relationship between structural and functional parameters was statistically evaluated.</div></div><div><h3>Results</h3><div>The PPG group showed significantly lower RNFL and mGCC thickness values than the healthy group. The MD, PSD, and VFI did not differ significantly between the groups. For AAP-2C, the PPG group showed significantly lower sensitivity than healthy individuals. A statistically significant positive correlation between was observed between AAP-2C and mGCC thickness (<em>p</em> = 0.003, <em>r</em> = 0.385). However, the RNFL and mGCC thickness values showed no statistically significant correlations with the MD, PSD, and VFI.</div></div><div><h3>Conclusion</h3><div>Although no glaucomatous change was observed in the VF in patients with PPG, these patients showed reduced sensitivity of the additional points. The reduced sensitivity of the additional points in the 24-2C VF test may reflect early macular functional alterations that correlate with structural damage during the pre-perimetric period.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104513"},"PeriodicalIF":3.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights on antibacterial mode of action of blue-light photoactivated berberine and curcumin-antibiotic combinations against Staphylococcus aureus","authors":"Ariana S.C. Gonçalves ,&nbsp;José R. Fernandes ,&nbsp;Maria José Saavedra ,&nbsp;Nuno M. Guimarães ,&nbsp;Cristiana Pereira ,&nbsp;Manuel Simões ,&nbsp;Anabela Borges","doi":"10.1016/j.pdpdt.2025.104514","DOIUrl":"10.1016/j.pdpdt.2025.104514","url":null,"abstract":"<div><div>Antimicrobial photodynamic inactivation (aPDI), using photosensitisers in combination with antibiotics, is a promising multi-target strategy to address antibiotic resistance, particularly in wound infections. This study aimed to elucidate the antibacterial mode of action of combinations of berberine (Ber) or curcumin (Cur) with selected antibiotics (Ber-Ab or Cur-Ab) under blue light irradiation (420 nm) against <em>Staphylococcus aureus</em>, including methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains. Multiple physiological parameters were assessed using complementary assays (fluorometry, epifluorescence microscopy, flame emission and atomic absorption spectroscopy, zeta potential, flow cytometry, and the plate agar method) to examine the effect on ROS production, membrane integrity, DNA damage, motility and virulence factors of <em>S. aureus</em>. Results indicated that blue light photoactivated Ber-Ab and Cur-Ab combinations led to substantial ROS generation, even at low concentrations, causing oxidative stress that severely impacted bacterial membrane integrity (approximately 90 % in MRSA and 40 % in MSSA). Membrane destabilization was further confirmed by elevated intercellular potassium release (≈ 2.00 and 2.40 µg/mL in MRSA and MSSA, respectively). Furthermore, significant DNA damage was observed in both strains (≈ 50 %). aPDI treatment with blue light also reduced <em>S. aureus</em> pathogenicity by impairing motility and inhibiting key virulence factors such as proteases, lipases, and gelatinases, all of which play key roles in the infectious process. Overall, Ber-Ab combinations demonstrated the highest efficacy across all parameters tested, highlighting for the first time the multi-target therapeutic potential of this phytochemical-based aPDI strategy to combat antibiotic-resistant <em>S. aureus</em> infections and improve wound infection treatment outcomes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104514"},"PeriodicalIF":3.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second harmonic generation-mediated Photodynamic Therapy for Staphylococcus aureus: A novel approach using Bismuth Ferrite-Protoporphyrin IX conjugates","authors":"Manu Kumar ,&nbsp;Avinash Jukanti ,&nbsp;Rivka Cahan ,&nbsp;Ariel Nause ,&nbsp;Refael Minnes","doi":"10.1016/j.pdpdt.2025.104512","DOIUrl":"10.1016/j.pdpdt.2025.104512","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a minimally invasive treatment modality that utilizes photosensitizing agents, light, and molecular oxygen to produce cytotoxic reactive oxygen species (ROS) to treat cancerous cells and bacterial infections. However, the effectiveness of PDT is often limited by the penetration depth of the light used to activate the photosensitizer (PS). We propose an effective method to address this challenge using Second Harmonic Generation (SHG), a nonlinear optical process in which two identical photons combine to form a new photon with double the frequency. This technique enables the utilization of longer wavelengths for enhanced tissue penetration, subsequently converting them into shorter wavelengths that align with the absorption characteristics of the photosensitizer. Thus, to achieve a highly effective production of SHG, we successfully synthesized the Harmonic Nanoparticle (HNP), Bismuth Ferrite (BFO). Subsequently, BFO was conjugated with Protoporphyrin IX (PPIX) to get BFO-PPIX conjugates for PDT treatment. These were exposed to Near Infrared (NIR) femtoseconds pulsed laser with a wavelength of 798 nm. PDT experiments using BFO-PPIX conjugates and an 8-minute irradiation by a 798 nm pulse laser reduced the survival rate of cultured Staphylococcus aureus (<em>S. aureus</em>) bacterial cells to 44.5 % ± 3.4 %. To the best of our knowledge, BFO and BFO-PPIX conjugates have not been used previously for advancing the conventional PDT treatment using SHG for deeper and precise treatment in <em>S. aureus.</em></div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104512"},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of retinal curvature with ocular biometry in patients with myopia","authors":"Guo-Ren Xu ,&nbsp;Ming Yan ,&nbsp;Zhen Huang ,&nbsp;Ya Ye ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2025.104505","DOIUrl":"10.1016/j.pdpdt.2025.104505","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the relationship between retinal curvature (RC) and ocular biometry in patients with myopia.</div></div><div><h3>Method</h3><div>The clinical data of 74 patients with myopia (148 eyes) were retrospectively analyzed. Macular 24×20 mm optical coherence tomography (OCT) scans were acquired using an ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) system. The software then identified the Bruch's membrane and integrated it with the axial length (AL) for morphological correction, yielding a fitted three-dimensional retinal model. From this model, an RC map was generated, detailing the Gaussian curvature at each point. The maximum retinal curvature (RCmax) and central macular retinal curvature (RCc) were analyzed.</div></div><div><h3>Results</h3><div>A total of 148 eyes were analyzed. The analysis revealed that RCmax was negatively correlated with AL (<em>r</em>=-0.266, <em>P</em> &lt; 0.05) and positively correlated with mean keratometry (Km) (<em>r</em> = 0.285, <em>P</em> &lt; 0.05). RCc was also positively correlated with Km (<em>r</em> = 0.167, <em>P</em> &lt; 0.05), whereas RCmax and RCc were positively correlated with each other (<em>r</em> = 0.450, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>In eyes with large innate eyeballs (characterized by a smaller Km), the RCmax was smaller, and acquired axial elongation (characterized by a larger AL) led to a reduction in RCmax, and vice versa. Eyes with large innate eyeballs also showed a smaller RCc, and vice versa.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104505"},"PeriodicalIF":3.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of retinal displacement after macular hole surgery and its correlation with postoperative visual function","authors":"Naxin Duan ,&nbsp;Lin Liu ,&nbsp;Song Lin,&nbsp;Zetong Nie,&nbsp;Siqiong Bai,&nbsp;Boshi Liu,&nbsp;Xiaorong Li,&nbsp;Wenbo Li ,&nbsp;Bojie Hu","doi":"10.1016/j.pdpdt.2025.104503","DOIUrl":"10.1016/j.pdpdt.2025.104503","url":null,"abstract":"<div><h3>Purpose</h3><div>To observe retinal displacement following macular hole surgery using a three-dimensional barycenter localization algorithm and to evaluate its relationship with postoperative visual function.</div></div><div><h3>Methods</h3><div>This prospective study included 28 eyes of 27 patients with idiopathic macular holes. A customized algorithm takes a weighted sum to locate the perimacular area (PMA) barycenter based on the magnitude of the distance between the barycenter and the intersection of retinal vessels. Retinal displacement distance, angle, and the rate of change in the PMA were calculated by comparing the barycenters in preoperative and postoperative photographs. Correlations between retinal displacement and various clinical parameters were also analyzed.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcomes included retinal displacement characteristics (distance, angle, and rate of change in the PMA). Secondary outcomes were postoperative visual function, including best-corrected visual acuity, mean retinal sensitivity, and fixation stability.</div></div><div><h3>Results</h3><div>A significant \"rebound\" phenomenon, characterized by PMA wrinkling and extension, was observed in 11 cases (39.3 %). The PMA was lower at 1 month postoperatively compared to that preoperatively (<em>t</em> = 1.876, <em>p</em> = 0.025). The mean displacement distance at 1 and 3 months postoperatively was 7.725 ± 0.097 and 6.187 ± 0.827, respectively. Mean retinal sensitivity at 3 months postoperatively improved compared to preoperative values (<em>t</em> = -2.171, <em>p</em> = 0.039) and was significantly correlated with the rate of change in PMA at 3 months postoperatively (<em>t</em> = -2.162, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The three-dimensional barycenter localization algorithm effectively visualized retinal displacement. The PMA was shown to be associated with postoperative visual function in this analysis. The change trend of PMA and mean retinal sensitivity is consistent.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104503"},"PeriodicalIF":3.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study","authors":"Shuhei Suzuki ,&nbsp;Yoshiyuki Nagumo ,&nbsp;Kosuke Kojo ,&nbsp;Atsushi Ikeda ,&nbsp;Bunpei Isoda ,&nbsp;Akane Yamaguchi ,&nbsp;Kozaburo Tanuma ,&nbsp;Satoshi Nitta ,&nbsp;Masanobu Shiga ,&nbsp;Takashi Kawahara ,&nbsp;Shuya Kandori ,&nbsp;Akio Hoshi ,&nbsp;Hiromitsu Negoro ,&nbsp;Bryan J. Mathis ,&nbsp;Hiroyuki Nishiyama","doi":"10.1016/j.pdpdt.2024.104429","DOIUrl":"10.1016/j.pdpdt.2024.104429","url":null,"abstract":"<div><h3>Background</h3><div>To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience.</div></div><div><h3>Methods</h3><div>Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral resection of bladder tumors (TURBT) with orally 5-amibolevulinic acid at our institute. Surgical experience was categorized by urological experience (first-year and second-year) and PDD experience (&lt;10, 10–19, and ≥20 cases). Sensitivity, specificity, and accuracy rates were calculated based on PDD or white light (WL) findings and pathologic diagnosis. The bladder neck, trigone, and prostatic urethra were defined as areas with a high probability of tangential effect.</div></div><div><h3>Results</h3><div>A total of 108 patients and 343 specimens were extracted. The second-year surgeons had significantly higher accuracy rates than first-year surgeons (81.5 % vs. 69.0 %, <em>p</em> = 0.013), while PDD experience did not significantly affect accuracy rates (76.5, 75.5, and 69.0 %). In addition, the accuracy rate was also significantly lower in tangential effect areas (59.6 % vs. 80.8 %). Multivariate analysis identified urological experience as a significant factor improving accuracy rate (odds ratio [OR] 2.14) while tangential effects substantially reduced accuracy rate (OR 0.37). Notably, combining both PDD and WL resulted in a sensitivity exceeding 94 %, even in first-year urology residents and tangential effect areas.</div></div><div><h3>Conclusions</h3><div>Urological experience had a greater impact on diagnostic performance of PDD compared to PDD experience. The combination of PDD and WL findings may improve sensitivity and reduce the possibility of missed diagnoses for less experienced urology residents.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104429"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts","authors":"Jiaoquan Chen ,&nbsp;Xinyi Xie ,&nbsp;Yingxue Liu,&nbsp;Fengyi Chen,&nbsp;Yeqing Gong,&nbsp;Bihua Liang,&nbsp;Yiling Wu,&nbsp;Shiqi He,&nbsp;Yueming Li,&nbsp;Huilan Zhu,&nbsp;Shaoyin Ma","doi":"10.1016/j.pdpdt.2024.104407","DOIUrl":"10.1016/j.pdpdt.2024.104407","url":null,"abstract":"<div><h3>Significance</h3><div>Plantar warts, benign lesions on the soles of the feet, are caused by the human papillomavirus (HPV) infecting keratinocytes. Complete eradication of these warts is challenging, often leading to recurrences. This study evaluates the combined clinical efficacy of topical 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) and fractional carbon dioxide (CO₂) laser treatment for recalcitrant plantar warts.</div></div><div><h3>Approach</h3><div>Data from 10 patients with recalcitrant plantar warts were analyzed. Initially, thickened hyperkeratotic tissue was removed using a super-pulsed CO₂ laser. This was followed by fractional laser application, after which a 20 % 5-ALA cream was applied occlusively for 4 h. Patients then received He-Ne laser irradiation for 30 min at an energy density of 100 mW/cm², with treatments spaced 4 weeks apart.</div></div><div><h3>Results</h3><div>The study included 10 participants aged 24 to 53 years (mean age: 33.4 ± 8.09 years). In total, 40 lesions were treated across 1 to 9 PDT sessions, with an average of 5.2 ± 2.86 sessions per patient. Complete clearance was achieved in 3 patients (30 %), 4 patients (40 %) showed an excellent response (≥80 % improvement), while 2 patients had a partial response. One patient (10 %) showed &lt;50 % improvement. The overall clearance rate was 70 % (28 out of 40 lesions). Aside from temporary pain during the procedure and mild erythema post-treatment, one patient developed localized proliferative scarring. After a one-year follow-up, only one patient experienced recurrence.</div></div><div><h3>Conclusions</h3><div>The combination of 5-ALA PDT and fractional CO₂ laser therapy shows promise as an effective and safe alternative for treating persistent plantar warts.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104407"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The disinfectant effects of portable ultraviolet light devices and their application to dentures","authors":"Kae Harada ,&nbsp;Reiya Horinouchi ,&nbsp;Mamoru Murakami ,&nbsp;Masakazu Isii ,&nbsp;Yuji Kamashita ,&nbsp;Naohiro Shimotahira ,&nbsp;Fumio Suehiro ,&nbsp;Yasuhiro Nishi ,&nbsp;Hiroshi Murata ,&nbsp;Masahiro Nishimura","doi":"10.1016/j.pdpdt.2024.104434","DOIUrl":"10.1016/j.pdpdt.2024.104434","url":null,"abstract":"<div><div>Interest in ultraviolet (UV) light devices for disinfection has increased due to pandemic concerns, but their efficacy in denture disinfection is underexplored. This study evaluated seven-enclosed type portable UV irradiation devices (devices A–G). Among these, devices A, B, and C used bulb light sources, while devices D, E, F, and G utilized LED (light-emitting diode) light sources. All devices were assessed in agar plate assay, and <em>Candida albicans</em> and <em>Staphylococcus aureus</em> spread on agar plates and irradiated under two conditions: inoculated surface facing upward and downward. Colony counts were recorded. Devices A and D were tested on <em>C. albicans</em>-contaminated dentures immersed in <em>C. albicans</em> medium, with samples collected before and after irradiation on the mucosal surfaces of the dentures. Device A was tested on denture-wearing patients in a clinical study, with samples collected from mucosal surfaces before and after irradiation to assess microbial CFUs (colony forming units). Devices A, C, and D significantly reduced <em>C. albicans</em> and <em>S. aureus</em> on plates with the inoculated surface facing upward, while device F showed a slight reduction when the inoculated surfaces were facing downward. Devices A and D eliminated <em>C. albicans</em> on contaminated dentures in vitro. Device A reduced all microorganism CFUs on denture surfaces in clinical studies. This study demonstrates that some portable UV light devices effectively reduce microbial contamination on denture surfaces, suggesting their potential as valuable tools for improving denture hygiene in the future.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104434"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of retinal vascular abnormalities in the fellow eyes of children with Coats’ disease and normal subjects using ultra-widefield fundus fluorescein angiography","authors":"Shenshen Yan ,&nbsp;Haixia Ji ,&nbsp;Yuzhu Liu ,&nbsp;Haicheng She ,&nbsp;Haiying Zhou","doi":"10.1016/j.pdpdt.2024.104455","DOIUrl":"10.1016/j.pdpdt.2024.104455","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate retinal vascular abnormalities in the affected and fellow eyes of children with Coats’ disease using Optos® ultra-widefield fundus fluorescein angiography (UWFFA) and compare the peripheral vascular abnormalities between fellow eyes and normal control eyes.</div></div><div><h3>Methods</h3><div>Children diagnosed with Coats’ disease who underwent UWFFA were retrospectively reviewed. Healthy eyes with complete UWFFA data were selected as controls. Retinal vascular abnormalities of the primary affected, fellow eyes and normal control eyes were recorded by investigating the UWFFA images.</div></div><div><h3>Results</h3><div>Among the 190 eyes of 95 patients with unilateral Coats’ disease, 83 (87.4%) were male, and the median age was 9.00 (7.00, 12.25) years (4–18 years). 93 (97.9%) fellow eyes had peripheral capillary telangiectasia that most commonly located in the temporal periphery. 59 (62.1%) fellow eyes had microaneurysms and 19 (20.0%) had vascular leakage; 29 (30.5%) fellow eyes had peripheral vascular tortuosity and 86 (90.5%) eyes had peripheral right-angle vessels. Peripheral capillary non-perfusion (CNP) were found in 31.6% (30/95) fellow eyes. We also found that the terminal vascular patterns in the fellow eyes were mainly loop pattern, accounting for 90.5%. The incidence of capillary bed abnormalities, vascular leakage, right-angle vessels and CNP were significantly higher in fellow eyes of Coats’ disease than control eyes (p&lt;0.001, p=0.044, p&lt;0.001, p=0.001, respectively). Regarding the terminal vascular patterns, the proportion of loop pattern in fellow eye group was significantly higher than that in control eye group (p&lt;0.001). A total of 21 Coats’ patients had follow-up UWFFA data. The average follow-up time was 13.19±10.09 (3–35) months. There was no significant change in peripheral retinal vascular abnormalities in the fellow eye of all patients between the first and last visit.</div></div><div><h3>Conclusions</h3><div>Because Optos® UWFFA device is able to quickly take panoramic fundus images using mild excitation light without contacting the cornea, it allows the detection of peripheral vascular changes in the fellow eyes of children with Coats’ disease. Contrary to the previous belief that Coats’ disease is a “unilateral condition”, our finding shows that Coats’ disease appears to be a highly asymmetric bilateral disease, and the peripheral vascular abnormalities in the fellow eye remains stable in short term.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104455"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}