Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Increased choroidal stromal volume and altered choriocapillaris perfusion in neovascular AMD: An SS-OCTA association study","authors":"Xuelin Chen ,&nbsp;Xuenan Zhuang ,&nbsp;Guiqin He ,&nbsp;Miaoling Li ,&nbsp;Xiongze Zhang ,&nbsp;Jiaxin Pu ,&nbsp;Yuying Ji ,&nbsp;Yining Zhang ,&nbsp;Xinlei Hao ,&nbsp;Feng Wen","doi":"10.1016/j.pdpdt.2025.105327","DOIUrl":"10.1016/j.pdpdt.2025.105327","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to characterize quantitative choroidal metrics using swept-source optical coherence tomography angiography (SS-OCTA) across different stages associated with neovascular age-related macular degeneration (nAMD) and to identify structural and vascular associations.</div></div><div><h3>Methods</h3><div>This cross-sectional study utilized SS-OCTA to quantify 6.0 × 6.0 mm² macular choriocapillaris flow density (CCFD), choroidal volume (CV), choroidal stromal volume (CSV), and choroidal vascular volume (CVV), choroidal stromal index (CSI), choroidal vascularity index (CVI) and CSV/CVV ratio. Comparisons were conducted between each pair of three groups: control eyes from healthy participants, fellow eyes and nAMD affected eyes from the same unilateral nAMD patients (fellow eyes representing a potential preclinical stage).</div></div><div><h3>Results</h3><div>The study included 230 healthy control eyes from 116 age- and sex- matched participants, 110 unaffected fellow eyes and 104 nAMD affected eyes from 110 unilateral nAMD patients. Median CCFD was 45.33% (IQR: 4.82%) in controls, 46.50% (IQR: 2.35%) in fellow eyes and 44.41% (IQR: 6.68%) in nAMD eyes. Significant differences were found between controls and fellow eyes (Adjusted <em>P</em> = 0.003) and between fellow eyes and nAMD eyes (Adjusted <em>P</em> &lt; 0.001). Median CSV was significantly higher in both unaffected fellow eyes (5.92 mm³, IQR: 2.67 mm³; Adjusted <em>P</em> = 0.006) and nAMD affected eyes (6.12 mm³, IQR: 2.71 mm³; Adjusted <em>P</em> = 0.012) compared to controls (5.49 mm³, IQR: 2.00 mm³). Other absolute volumes also showed significant intergroup differences: CV differed between control and fellow eyes (Adjusted <em>P</em> = 0.033), while CVV differed significantly only between affected and fellow eyes (Adjusted <em>P</em> = 0.015). In contrast, normalized compositional metrics (CSI, CVI and CSV/CVV ratio) showed no significant intergroup differences (all Adjusted <em>P</em> &gt; 0.05). Multivariate regression analysis in nAMD affected eyes revealed an overall inverse correlation between CSV and CCFD, with this relationship reaching statistical significance the superior nasal, nasal, inferior temporal, inferior and inferior nasal quadrants (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This cross-sectional study demonstrated an association between increased CSV and the presence of nAMD, including in high-risk fellow eyes. The inverse correlation between CSV and CCFD in nAMD eyes suggested a potential interplay between stromal expansion and microvascular compromise. These findings highlighted increased CSV as a candidate biomarker that warranted investigation in future longitudinal studies to determine its prognostic value for nAMD development.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105327"},"PeriodicalIF":2.6,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of orthokeratology lenses on axial length, refractive power, and complications in myopic children under corneal curvature stratification","authors":"Feifei Shi,&nbsp;Feidi Li,&nbsp;Qunwu Tang,&nbsp;Huifeng Wu","doi":"10.1016/j.pdpdt.2025.105326","DOIUrl":"10.1016/j.pdpdt.2025.105326","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the long-term effects of orthokeratology lenses (OK lenses) on myopic children with different baseline corneal curvatures (CCs).</div></div><div><h3>Methods</h3><div>178 myopic children were categorized into three groups based on their CC: Axial Group (AG, CC ≤41.5D), Curvature Group (CG, CC ≥44D), and Mixed Group (MG, 41.5D ≤ CC ≤44D). The age range was from 6 to 15 years. The refractive error (RE), axial length (AL), CC, RE changes, axial elongation rate, changes in CC, corneal endothelial cell (CEC) parameters, and complications were compared among the three groups.</div></div><div><h3>Results</h3><div>After wearing glasses, the patients’ RE, CC, AL, and axial growth rate in all three groups were significantly improved compared to before wearing glasses (<em>P</em>&lt;0.05). The differences in AL increase at different time points after wearing glasses were not statistically significant (<em>F</em> = 10.20, <em>P</em> &gt; 0.05). The changes in CC in the AG were significantly different from those in the CG (<em>P</em> &lt; 0.05), and the AG showed a greater increase in AL after treatment compared to the CG and MG (<em>P</em> &lt; 0.05). For instance, the mean CC in the AG before wearing glasses was 41.82 ± 0.79D, which decreased to 38.17 ± 0.59D after two years of wearing glasses. In the CG, the mean CC before wearing glasses was 43.69 ± 1.57D, decreasing to 42.87 ± 1.08D after two years of wearing glasses. The differences in CEC density, mean cell area, coefficient of variation (COA), and hexagonal cell ratio (HCR) at various time points before and after wearing glasses and between the different groups were minimal (<em>P</em> &gt; 0.05). The complication rate was 58.62% in the AG, 41.82% in the CG, and 53.85% in the MG, with the CG showing the lowest complication rate after two years, which was significantly different from the other two groups (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>OK lenses demonstrate marked efficacy in controlling myopia, particularly in patients with higher CC, where the control of AL growth is notably effective. Additionally, CC is associated with the incidence of complications.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105326"},"PeriodicalIF":2.6,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a new type of visible light-based emission fluorescence microscope to identify the benign and malignant nature of thyroid tissue during the surgical process: Analysis of diagnostic results","authors":"Yu Miao ,&nbsp;Liu Xiaowei ,&nbsp;Li Muyang ,&nbsp;Gao Jian ,&nbsp;Chen Lu","doi":"10.1016/j.pdpdt.2025.105324","DOIUrl":"10.1016/j.pdpdt.2025.105324","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> This study evaluated the accuracy and reliability of a new type of visible light-based emission fluorescence microscope [the EndoSCell cell optical scanner (EndoSCell)] in identifying the pathological features of papillary thyroid carcinoma, the spread of lymph nodes in the neck, and the parathyroid glands.</div></div><div><h3>Method</h3><div><strong>:</strong> The thyroid papillary carcinoma tissue samples, lymph node tissue samples, and parathyroid tissue samples were diagnosed using EndoSCell images and frozen sections, and the detection times were recorded. The Hematoxylin and eosin (HE) staining results were used as the gold standard.</div></div><div><h3>Result</h3><div><strong>:</strong> EndoSCell boasts extremely high imaging clarity, enabling it to clearly distinguish the spatial distribution and morphological characteristics of stained cell nuclei and cytoplasm within the observed tissue samples (healthy tissues, lesion areas). The sensitivity, specificity and accuracy of using EndoSCell images to determine the benign or malignant nature of thyroid papilloma, the presence of cervical lymph node metastasis, and the status of parathyroid tissue were (96.43%, 100%, 97.22%), (92.6%, 92.3%, 92.5%), and (91.3%, 91.7%, 91.4%), respectively. The detection times for EndoSCell and frozen sections were 180.77 ± 45.03 s and 1835 ± 538.12 s respectively.</div></div><div><h3>Conclusion</h3><div><strong>:</strong> The diagnostic efficacy of EndoSCell is comparable to that of frozen sections, and the diagnostic results of EndoSCell are highly consistent with the pathological diagnosis of frozen sections. EndoSCell is expected to enable doctors to precisely and accurately remove cancerous tissues in real time while protecting important tissues such as the parathyroid glands and the recurrent laryngeal nerve.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105324"},"PeriodicalIF":2.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agent-specific differences in sustained intraoperative hypotension during oral 5-Aminolevulinic acid-guided transurethral resection of bladder tumor: A retrospective observational study","authors":"Yoshifumi Katsumata ,&nbsp;Shinkuro Yamamoto ,&nbsp;Hideki Iwata ,&nbsp;Hajime Kuroiwa ,&nbsp;Hideo Fukuhara ,&nbsp;Satoshi Fukata ,&nbsp;Keiji Inoue ,&nbsp;Takashi Kawano","doi":"10.1016/j.pdpdt.2025.105319","DOIUrl":"10.1016/j.pdpdt.2025.105319","url":null,"abstract":"<div><h3>Objectives</h3><div>Severe intraoperative hypotension is frequently reported during transurethral resection of bladder tumor (TURBT) using orally administered 5-aminolevulinic acid hydrochloride (5-ALA); however, the influence of anesthetic technique on prolonged hypotensive episodes remains unclear.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 423 consecutive patients who underwent oral 5-ALA-guided TURBT between 2018 and 2024. Sustained hypotension was defined as mean arterial pressure &lt;65 mmHg lasting ≥30 min. Baseline characteristics, anesthetic variables, and hemodynamic parameters were compared between patients with and without sustained hypotension. Multivariable logistic regression was used to identify independent predictors.</div></div><div><h3>Results</h3><div>Among patients receiving general anesthesia (n=274), the incidence of sustained hypotension varied significantly depending on the anesthetic agent (p=0.02). In multivariable logistic regression, remimazolam was independently associated with a significantly lower risk of sustained hypotension compared with sevoflurane (adjusted OR 0.35, 95% CI 0.14–0.83, p=0.02).</div></div><div><h3>Conclusions</h3><div>Approximately one-fourth of patients undergoing oral 5-ALA–guided TURBT experienced sustained intraoperative hypotension, with spinal anesthesia showing a lower incidence than general anesthesia. Longer anesthesia and surgical durations increased the risk. The choice of anesthetic agents under general anesthesia also appeared to affect the risk of sustained hypotension. These findings highlight the importance of individualized anesthetic management to maintain hemodynamic stability during this procedure.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105319"},"PeriodicalIF":2.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world data of verteporfin-related ocular adverse events: A disproportionality analysis","authors":"Nesrin Caglayan Duman ,&nbsp;Aslihan Uzun","doi":"10.1016/j.pdpdt.2025.105322","DOIUrl":"10.1016/j.pdpdt.2025.105322","url":null,"abstract":"<div><h3>Aim/Background</h3><div>To investigate verteporfin-induced ocular adverse events (AEs) by analysing real-world data reported in the US Food and Drug Administration's Adverse Event Reporting System (FAERS) database.</div></div><div><h3>Methods</h3><div>The OpenVigil 2.1-MedDRA-v24 disproportionality analysis software package, including the Reporting Odds Ratio (ROR) and Proportional Reporting Ratio (PRR) algorithms, was used to detect potential ocular AEs associated with verteporfin and to determine signal intensity. AE reports related to verteporfin as the primary suspect in the FAERS database between 01 January 2004 and 31 December 2024 were included in the study. The signal strengths were classified as low, medium and strong according to the ROR and PRR values.</div></div><div><h3>Results</h3><div>The most reported preferred terms (PTs) were ‘visual acuity reduced’ (<em>n</em> = 212), ‘retinal haemorrhage’ (<em>n</em> = 100), and ‘choroidal neovascularization’ (<em>n</em> = 77). However ‘polypoidal choroidal vasculopathy’ (ROR=3538.345, PRR=3420.433), ‘subretinal fibrosis’ (ROR=3376.777, PRR=3283.005) and ‘macular scar’ (ROR=2458.542, PRR=2414.169) had the highest signal strength. The results of disproportionality analysis of PTs with 3 or more ‘eye disorder’ reports associated with verteporfin (<em>n</em> = 52), revealed 40 strong, 7 moderate, and 5 weak signal intensities.</div></div><div><h3>Conclusion</h3><div>The most common verteporfin-related ocular AEs (reduced visual acuity, retinal haemorrhage and choroidal neovascularization) were consistent with the drug label. However dozens of new potential ocular AEs with strong signal strengths that were not listed in the drug label, were identified. It should be noted that the proportional data in the study cannot provide information about other drugs used for the same indications as verteporfin. A fully-comprehension of these AEs will be highly beneficial in deciding which patients should be closely monitored for verteporfin-related ocular AEs. However, we emphasis our view that this study should be supported by prospective, clinically conducted research, as data on verteporfin's therapeutic indications and dosage are unavailable in this study.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105322"},"PeriodicalIF":2.6,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal microvascular alterations in affected and contralateral eyes of individuals with unilateral central retinal artery occlusion","authors":"Jie Gao ,&nbsp;Huiwen Pang ,&nbsp;Weijie Zhang ,&nbsp;Yao Ge ,&nbsp;Maojuan Feng ,&nbsp;Jing Cao ,&nbsp;Tao Wang","doi":"10.1016/j.pdpdt.2025.105320","DOIUrl":"10.1016/j.pdpdt.2025.105320","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to evaluate retinal microvascular characteristics in affected and contralateral healthy eyes of patients diagnosed with central retinal artery occlusion (CRAO), and to determine the presence of subclinical microvascular alterations in the contralateral eye.</div></div><div><h3>Methods</h3><div>30 patients with unilateral CRAO were enrolled, with affected eyes designated as Group A and contralateral healthy eyes as Group B. An age-matched control group of 30 healthy individuals was included as Group C. All participants underwent assessment of best-corrected visual acuity (BCVA), intraocular pressure measurement, optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), and neck ultrasonography. Retinal microvascular parameters, including central retinal thickness (CRT), foveal avascular zone (FAZ), and vascular density (VD), were measured and statistically analyzed to identify subclinical alterations in contralateral eyes.</div></div><div><h3>Results</h3><div>Central retinal thickness (CRT) was higher in Group A (327.77±35.85 μm) than in Group C (251.17±7.02 μm, <em>p</em> &lt; 0.05) and lower in Group B (240.30±5.19 μm) than in Group C (<em>p</em> &lt; 0.05). The foveal avascular zone (FAZ) area differed significantly across all groups (A: 0.40±0.017 mm², B: 0.34±0.014 mm², C: 0.31±0.005 mm², <em>p</em> &lt; 0.05). Superficial capillary plexus vascular density (SCP-VD) was reduced in Group A (40.21 %±2.97 %) compared with Group B (45.78 %±3.16 %) and Group C (46.97 %±2.60 %, <em>p</em> &lt; 0.05), with no significant difference between Groups B and C. Deep Capillary Plexus (DCP-VD) and Radial Peripapillary Capillary (RPC-VD) densities differed significantly among all groups (<em>p</em> &lt; 0.05). CRT in Group B demonstrated a correlation with SCP-VD (<em>p</em> = 0.016).</div></div><div><h3>Conclusion</h3><div>Subclinical microvascular alterations may be present in the contralateral healthy eyes of patients with CRAO, indicating a potential association between CRAO and systemic vascular changes. These findings underscore the importance of early evaluation of both eyes. OCTA serves as a valuable tool for visualizing retinal vascular structures, and supports early detection and management of retinal vascular abnormalities associated with CRAO.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105320"},"PeriodicalIF":2.6,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of 5-aminolevulenic acid fluorescence for diagnostic guidance in intracranial lymphoma surgery: A case series and systematic review of 170 patients","authors":"Dong-Won Shin,&nbsp;Joon-Hyuk Jeong,&nbsp;Gi-Taek Yee","doi":"10.1016/j.pdpdt.2025.105318","DOIUrl":"10.1016/j.pdpdt.2025.105318","url":null,"abstract":"<div><h3>Background</h3><div>Intracranial lymphomas are rare tumors of the central nervous system, predominantly affecting elderly patients. While 5-aminolevulinic acid (5-ALA) fluorescence is well established in glioma surgery, its diagnostic role in intracranial lymphoma remains unclear, particularly regarding the effect of corticosteroid use. This study evaluated the diagnostic performance of 5-ALA-guided biopsy and its relationship with corticosteroid exposure.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case series and a systematic review. Adult patients who underwent stereotactic or open biopsy with 5-ALA guidance for radiologically suspected intracranial lymphoma at Gachon University Gil Medical Center (2022–2025) were analyzed. A comprehensive literature search (MEDLINE, EMBASE, Web of Science, Cochrane Library) through May 2025 identified studies reporting 5-ALA use in intracranial lymphoma biopsy. Diagnostic yield, fluorescence patterns, and corticosteroid effects were assessed.</div></div><div><h3>Results</h3><div>Five patients were included in the institutional series: strong fluorescence was observed in four and vague in one, with an overall positive predictive value of 80 %. Across 18 studies (170 patients), 5-ALA fluorescence was detected in 77.6 %, with 78 % pooled sensitivity and 22 % false-negative rate. Among 12 patients with documented corticosteroid use, discontinuation ≥7 days before biopsy correlated with higher fluorescence positivity, though not consistently with diagnostic success.</div></div><div><h3>Conclusions</h3><div>5-ALA fluorescence serves as a useful adjunct for intracranial lymphoma biopsy, enhancing sampling efficiency and procedural safety. However, fluorescence alone cannot ensure diagnostic adequacy, and frozen section confirmation remains necessary. Corticosteroid use does not uniformly suppress fluorescence but may influence diagnostic reliability.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105318"},"PeriodicalIF":2.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional retinal curvature remodeling and choroidal changes following posterior scleral reinforcement in high myopia: A quantitative multimodal imaging study","authors":"Xiaoxiao Wu ,&nbsp;Xiyue Tan ,&nbsp;Yingying Nie ,&nbsp;Yining Zeng ,&nbsp;Youruo Zhang ,&nbsp;Mingxue Gao ,&nbsp;Qiulin Mi ,&nbsp;Xue Zhou ,&nbsp;Junguo Duan","doi":"10.1016/j.pdpdt.2025.105317","DOIUrl":"10.1016/j.pdpdt.2025.105317","url":null,"abstract":"<div><h3>Purpose</h3><div>To quantitatively assess retinal curvature and microvascular changes following posterior scleral reinforcement (PSR) using the BM-400 K SS-OCTA system.</div></div><div><h3>Methods</h3><div>This pilot study enrolled 21 highly myopic eyes undergoing PSR. Baseline and postoperative (1/3/6 months) assessments included best-corrected visual acuity (BCVA), spherical equivalent (SE), and axial length (AL). The BM-400 K system measured retinal curvature (RC), choroidal thickness (ChT), superficial/deep capillary plexus density (SCP/DCP), and choroidal vascular index (CVI).</div></div><div><h3>Results</h3><div>Significant axial shortening occurred, peaking at 3 months (median AL: 27.98 mm vs. baseline 28.61 mm, <em>P</em> &lt; 0.01). Progressive retinal flattening was observed (RC: 0.48 D/mm at 6 months vs. 0.77 D/mm baseline, <em>P</em> = 0.004). Strong correlations emerged between curvature changes (∆RC) and AL reduction (e.g., ∆RC3 vs. ∆AL at 6 months, <em>rₛ</em>=0.861, FDR-adj. <em>P</em> = 0.010). Notably, ∆RC correlated negatively with profound capillary density changes in specific regions (e.g., ∆RC4 vs. ∆DCP4, <em>r</em>ₛ= −0.756, FDR-adj. <em>P</em> = 0.021).</div></div><div><h3>Conclusion</h3><div>BM-400K-based quantitative RC analysis demonstrates that PSR induces significant retinal flattening, which is linked to axial shortening and microvascular remodeling. This novel optical evaluation provides critical structural and hemodynamic insights for PSR outcome assessment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105317"},"PeriodicalIF":2.6,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined fluorescein sodium and intraoperative ultrasound enhance resection and functional outcomes in high-grade glioma surgery","authors":"Xin Tian ,&nbsp;Boyu Sun ,&nbsp;Hongbo Cheng ,&nbsp;Xiaohui Hao ,&nbsp;Guozhu Sun ,&nbsp;Jinmin Hao ,&nbsp;Ling Chen","doi":"10.1016/j.pdpdt.2025.105316","DOIUrl":"10.1016/j.pdpdt.2025.105316","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the clinical efficacy of combining fluorescein sodium with intraoperative ultrasound (ioUS) for microsurgical resection of high-grade gliomas (HGGs).</div></div><div><h3>Methods</h3><div>In this multicenter retrospective cohort study, 228 patients with HGG were grouped based on the surgical approach: 122 underwent fluorescein sodium + ioUS-guided resection, whereas single-centre 106 received conventional microsurgery (control). Outcomes included gross total resection (GTR) rates, tumour recurrence at 3–6 months, postoperative Karnofsky Performance Status (KPS) scores, intraoperative haemorrhage value and operation time, length of hospital stay and complications.</div></div><div><h3>Results</h3><div>The fluorescein sodium + ioUS group achieved significantly higher GTR rates (91.0 %¦vs 74.5 %; P &lt; 0.001) and lower recurrence rates at both 3 months (4.1 %¦vs 12.3 %; P = 0.027) and 6 months (9.0 %¦vs 23.6 %; P = 0.002) than the control group. Functional recovery (the KPS) improved more substantially in the fluorescein sodium + ioUS group at 1 month (85.9 vs 77.6; P &lt; 0.001) and 6 months (90.9 vs 82.5; P &lt; 0.001) postoperatively. Intraoperative haemorrhage (255.9 vs 338.5 mL), operation time (2.6 vs 3.4 h) and hospital stay (14.8 vs 20.4 days) were significantly reduced (P &lt; 0.001 for all) in the fluorescein sodium + ioUS group compared with the control group. Complication rates did not differ significantly between the groups (P = 0.104).</div></div><div><h3>Conclusion</h3><div>This retrospective study suggests that the combination of fluorescein sodium and ioUS may improve GTR, reduce early recurrence, enhance functional recovery and optimise surgical efficiency in HGG resection. Prospective studies are warranted to confirm these results.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105316"},"PeriodicalIF":2.6,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the combination of trephination abrasion with 5-aminolevulinic acid photodynamic therapy for verruca plana: A retrospective study","authors":"Li-chao Zhang ,&nbsp;Hai-feng Huang ,&nbsp;Xian-fei Guo","doi":"10.1016/j.pdpdt.2025.105314","DOIUrl":"10.1016/j.pdpdt.2025.105314","url":null,"abstract":"<div><h3>Background</h3><div>Studies have shown that photodynamic therapy (PDT) is an effective and non-invasive technique for treating verruca plana. However, due to the limited penetration depth of photosensitizers and light sources, the efficacy of PDT for patients with verruca plana is still limited. Herein, we adopted trephination abrasion combined with 5-aminolevulinic acid (ALA) PDT for verruca plana.</div></div><div><h3>Methods</h3><div>A retrospective study of trephination abrasion combined with ALA-PDT for verruca plana was conducted. After the warts were superficially abraded by a disposable biopsy punch as trephine, ALA-PDT was performed. The effective rate was calculated with the cured and excellent response rates.</div></div><div><h3>Results</h3><div>A total of 50 patients were reported in this study. At the second week, 25 (50.0 %) patients showed complete response and 10 (20.0 %) patients showed excellent response, resulting in a total effectiveness rate of 70.0 %. At the fourth week, 47 (94.0 %) patients showed complete response and one (2.0 %) patient showed excellent response, resulting in a total effectiveness rate of 96.0 %. At the sixth week, 49 (98.0 %) patients showed complete response and one (2.0 %) patient showed excellent response, resulting in a total effectiveness rate of 100.0 %. Two (4.1 %) patients experienced recurrence at the 24th week, resulting in a total effectiveness rate of 96.0 %. At the 6-month follow-up, no hyperpigmentation was observed.</div></div><div><h3>Conclusions</h3><div>A combination of trephination abrasion with ALA-PDT was safe, economical and effective in treatment for verruca plana.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105314"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}