Pub Date : 2025-08-28DOI: 10.1152/physrev.00002.2025
Lachlan D. Rash, Stephan Kellenberger
Physiological Reviews, Ahead of Print.
《生理评论》，出版前。
{"title":"Acid-sensing ion channels: structure, function, pharmacology and clinical significance","authors":"Lachlan D. Rash, Stephan Kellenberger","doi":"10.1152/physrev.00002.2025","DOIUrl":"https://doi.org/10.1152/physrev.00002.2025","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"57 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-28DOI: 10.1152/physrev.00052.2024
Wei R Tan, David A Long, Luigi Gnudi
Physiological Reviews, Ahead of Print.
《生理评论》，出版前。
{"title":"Neurite outgrowth inhibitor-B (Nogo-B) in physiology and disease.","authors":"Wei R Tan, David A Long, Luigi Gnudi","doi":"10.1152/physrev.00052.2024","DOIUrl":"https://doi.org/10.1152/physrev.00052.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"53 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-28DOI: 10.1152/physrev.00054.2024
Nicolas D. Lutz, Maximilian Harkotte, Jan Born
Physiological Reviews, Ahead of Print.
《生理评论》，出版前。
{"title":"Sleep‘s contribution to memory formation","authors":"Nicolas D. Lutz, Maximilian Harkotte, Jan Born","doi":"10.1152/physrev.00054.2024","DOIUrl":"https://doi.org/10.1152/physrev.00054.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"29 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.1152/physrev.00057.2024
Lærke S. Gasbjerg, Casper K. Nielsen, Malte P. Suppli, Magnus F. G. Grøendahl, Jens J. Holst, Filip K. Knop, Palle B. Jeppesen, Asger B. Lund
Physiological Reviews, Ahead of Print.
《生理评论》，出版前。
{"title":"Proglucagon-derived Peptides: Human Physiology and Therapeutic Potential","authors":"Lærke S. Gasbjerg, Casper K. Nielsen, Malte P. Suppli, Magnus F. G. Grøendahl, Jens J. Holst, Filip K. Knop, Palle B. Jeppesen, Asger B. Lund","doi":"10.1152/physrev.00057.2024","DOIUrl":"https://doi.org/10.1152/physrev.00057.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"26 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-23DOI: 10.1152/physrev.00046.2024
Alexander M Jordan,Rebecca J G Drake,Kairbaan M Hodivala-Dilke
The emergence of treatment resistance and metastasis are significant challenges that need to be addressed to improve cancer patient outcomes. Greater insight into the mechanisms regulating these processes is needed to identify novel targets for the development of effective treatments. The importance of blood vessel interactions, including endothelial angiocrine and pericyte pericrine signals, with surrounding tissues, has been well established in regulating several normal physiological functions, including angiogenesis, metabolism, wound healing and development. They have also been implicated in the mechanisms of cancer growth, metastatic dissemination, regulation of the immune microenvironment and therapeutic resistance. This review provides an overview of the angiocrine and pericrine processes that regulate cancer, the tumor microenvironment and therapy responses. It highlights that endothelial cells and pericytes are not only important in maintaining blood vessel structure in cancer, but that their signaling roles are a pivotal regulatory element harnessed by tumors, some of which could be targeted for alternative cancer treatment strategies. Here, we summarize current research targeting angiocrine and pericrine signaling in cancer and propose new approaches for thorough exploration of these networks to further disentangle the intricate mechanisms at play.
{"title":"Angiocrine and Pericrine Signaling: How Endothelial Cells and Pericytes Drive Cancer Progression and Therapy Resistance.","authors":"Alexander M Jordan,Rebecca J G Drake,Kairbaan M Hodivala-Dilke","doi":"10.1152/physrev.00046.2024","DOIUrl":"https://doi.org/10.1152/physrev.00046.2024","url":null,"abstract":"The emergence of treatment resistance and metastasis are significant challenges that need to be addressed to improve cancer patient outcomes. Greater insight into the mechanisms regulating these processes is needed to identify novel targets for the development of effective treatments. The importance of blood vessel interactions, including endothelial angiocrine and pericyte pericrine signals, with surrounding tissues, has been well established in regulating several normal physiological functions, including angiogenesis, metabolism, wound healing and development. They have also been implicated in the mechanisms of cancer growth, metastatic dissemination, regulation of the immune microenvironment and therapeutic resistance. This review provides an overview of the angiocrine and pericrine processes that regulate cancer, the tumor microenvironment and therapy responses. It highlights that endothelial cells and pericytes are not only important in maintaining blood vessel structure in cancer, but that their signaling roles are a pivotal regulatory element harnessed by tumors, some of which could be targeted for alternative cancer treatment strategies. Here, we summarize current research targeting angiocrine and pericrine signaling in cancer and propose new approaches for thorough exploration of these networks to further disentangle the intricate mechanisms at play.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"14 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-16DOI: 10.1152/physrev.00022.2024
István Vadász, Eoin P Cummins, Deborah H. Brotherton, S Marina Casalino Matsuda, Laura A. Dada, Ori Green, Dustin T. King, Vitalii Kryvenko, Masahiko Shigemura, Peter H. S. Sporn, Moritz J. Strowitzki, Martin J. Cann, Jacob I. Sznajder
Physiological Reviews, Ahead of Print.
《生理评论》，出版前。
{"title":"Sensing molecular carbon dioxide - a translational focus for respiratory disease","authors":"István Vadász, Eoin P Cummins, Deborah H. Brotherton, S Marina Casalino Matsuda, Laura A. Dada, Ori Green, Dustin T. King, Vitalii Kryvenko, Masahiko Shigemura, Peter H. S. Sporn, Moritz J. Strowitzki, Martin J. Cann, Jacob I. Sznajder","doi":"10.1152/physrev.00022.2024","DOIUrl":"https://doi.org/10.1152/physrev.00022.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"267 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-11DOI: 10.1152/physrev.00043.2024
Gary C Sieck,Matthew J Fogarty
In mammals, breathing requires an inspiratory pump to generate a negative intrathoracic pressure and thus pull air into the lungs for gas exchange. Exclusively in mammals, the diaphragm muscle (DIAm) is the major inspiratory pump, which separates the thoracic and abdominal cavities. With DIAm contraction a negative intrathoracic and positive abdominal pressure are generated (i.e., transdiaphragmatic pressure (Pdi). During breathing,the DIAm is very active, with a duty cycle (time active vs inactive) similar to that of the heart. Like the heart, this is a pump that cannot fail! Thus, in controlling breathing, the nervous system must activate DIAm to accomplish pump function while avoiding fatigue. The timing of DIAm activations must also be coordinated with activation of the upper airway muscles (the pipes) to avoid airway occlusion and aspiration, the intercostal and abdominal muscles to appropriately stiffen the body cavities. Similarly, neural control and coordination of the DIAm in non-ventilatory behaviors (airway protection, swallowing, vocalization and voiding) is equally complex, with coordinated activation of the DIAm and abdominal muscles. It is becoming increasingly clear that impaired non-ventilatory functions underlie the pathophysiology of a variety of medical conditions. In this review, we will delve into the detailed mechanistic underpinnings of the neural control of the DIAm and the symphonic coordination of its activation during breathing and other behaviors. We will attempt to move the field from considering the DIAm only as an inspiratory pump, emphasising neural control of airway, intercostal and abdominal muscles that must be coordinated with DIAm activation.
{"title":"Diaphragm Muscle: A Pump That Can Not Fail.","authors":"Gary C Sieck,Matthew J Fogarty","doi":"10.1152/physrev.00043.2024","DOIUrl":"https://doi.org/10.1152/physrev.00043.2024","url":null,"abstract":"In mammals, breathing requires an inspiratory pump to generate a negative intrathoracic pressure and thus pull air into the lungs for gas exchange. Exclusively in mammals, the diaphragm muscle (DIAm) is the major inspiratory pump, which separates the thoracic and abdominal cavities. With DIAm contraction a negative intrathoracic and positive abdominal pressure are generated (i.e., transdiaphragmatic pressure (Pdi). During breathing,the DIAm is very active, with a duty cycle (time active vs inactive) similar to that of the heart. Like the heart, this is a pump that cannot fail! Thus, in controlling breathing, the nervous system must activate DIAm to accomplish pump function while avoiding fatigue. The timing of DIAm activations must also be coordinated with activation of the upper airway muscles (the pipes) to avoid airway occlusion and aspiration, the intercostal and abdominal muscles to appropriately stiffen the body cavities. Similarly, neural control and coordination of the DIAm in non-ventilatory behaviors (airway protection, swallowing, vocalization and voiding) is equally complex, with coordinated activation of the DIAm and abdominal muscles. It is becoming increasingly clear that impaired non-ventilatory functions underlie the pathophysiology of a variety of medical conditions. In this review, we will delve into the detailed mechanistic underpinnings of the neural control of the DIAm and the symphonic coordination of its activation during breathing and other behaviors. We will attempt to move the field from considering the DIAm only as an inspiratory pump, emphasising neural control of airway, intercostal and abdominal muscles that must be coordinated with DIAm activation.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"4 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-10DOI: 10.1152/physrev.00053.2024
Modan R Goldman,Mariel Molina-Castro,Jumar C Etkins,Theodore L Koide,Vijay A Ramchandani,Martin H Plawecki,Julie A Mennella,Marta Yanina Pepino
Globally, alcohol is the most widely used psychoactive drug and a leading cause of premature death among individuals aged 15-49 years. Understanding the absorption, distribution, metabolism, and excretion of alcohol in the human body, otherwise known as alcohol pharmacokinetics, is essential for predicting its behavioral effects and toxic consequences. This review examines the evolutionary origins of alcohol consumption and metabolism, focusing on the activity of alcohol dehydrogenase enzymes across species, which serve as key catalysts in alcohol oxidation. It also highlights recent advances in understanding central alcohol metabolism and updates on the potential clinical significance of non-oxidative pathways of alcohol metabolism and endogenous alcohol production, particularly in the context of liver disease. In addition, the review inspects factors that modulate alcohol metabolism, including genetic polymorphisms, biological sex, food intake, women's reproductive status, and clinical interventions such as medications and metabolic surgeries. Understanding these sources of variability in alcohol metabolism is crucial for identifying individual risk factors and tailoring strategies to reduce alcohol-related harm. This comprehensive review offers a current perspective on alcohol pharmacokinetics, valuable insights into its implications for health, behavior, and potential innovative therapeutic targets.
{"title":"Recent advances in alcohol metabolism: from the gut to the brain.","authors":"Modan R Goldman,Mariel Molina-Castro,Jumar C Etkins,Theodore L Koide,Vijay A Ramchandani,Martin H Plawecki,Julie A Mennella,Marta Yanina Pepino","doi":"10.1152/physrev.00053.2024","DOIUrl":"https://doi.org/10.1152/physrev.00053.2024","url":null,"abstract":"Globally, alcohol is the most widely used psychoactive drug and a leading cause of premature death among individuals aged 15-49 years. Understanding the absorption, distribution, metabolism, and excretion of alcohol in the human body, otherwise known as alcohol pharmacokinetics, is essential for predicting its behavioral effects and toxic consequences. This review examines the evolutionary origins of alcohol consumption and metabolism, focusing on the activity of alcohol dehydrogenase enzymes across species, which serve as key catalysts in alcohol oxidation. It also highlights recent advances in understanding central alcohol metabolism and updates on the potential clinical significance of non-oxidative pathways of alcohol metabolism and endogenous alcohol production, particularly in the context of liver disease. In addition, the review inspects factors that modulate alcohol metabolism, including genetic polymorphisms, biological sex, food intake, women's reproductive status, and clinical interventions such as medications and metabolic surgeries. Understanding these sources of variability in alcohol metabolism is crucial for identifying individual risk factors and tailoring strategies to reduce alcohol-related harm. This comprehensive review offers a current perspective on alcohol pharmacokinetics, valuable insights into its implications for health, behavior, and potential innovative therapeutic targets.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"147 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：