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Quantification of age-related changes in the elastic texture of the human aortic wall by directional fractal curve 用定向分形曲线量化人主动脉壁弹性结构的年龄相关变化
C.F. Jiang, A. Avolio
A new fractal feature, the Directional Fractal Curve (DFC), defined over an are of 180/spl deg/ and composed of 90 fractal dimensions determined at intervals of arc of 2/spl deg/, was developed to account for the anisotropic property of a fractal texture. The DFC of images with directional preference shows a periodic pattern; while the DFC of images with no definite directional preference tends to be a horizontal line. The DFC of the elastic texture exhibits a single peak and can be characterized by a sinusoidal function. The DFC was applied to examine an age-related structural change in the elastin network of the aortic wall exposed by scanning electron microcopy. Aortic samples were obtained from 44 human subjects with age range of 3 months to 103 years. Results show that the DFCs of these subjects decay significantly as age increases. This suggests that the elastin network may be characterized in terms of DFC which can be used to quantify structural modifications due to physiological changes such as ageing.
为了解释分形织构的各向异性,提出了一种新的分形特征——定向分形曲线(Directional fractal Curve, DFC),它定义在180/spl°/的分形曲线上,由90个以2/spl°/的弧间隔确定的分形维数组成。具有方向偏好的图像的DFC呈现周期性模式;而没有明确方向偏好的图像的DFC趋向于一条水平线。弹性织构的DFC表现为单峰,可以用正弦函数表征。应用DFC检查扫描电镜显示的主动脉壁弹性蛋白网络中年龄相关的结构变化。从44名年龄从3个月到103岁的人类受试者中获得主动脉样本。结果表明,随着年龄的增长,这些受试者的dfc显著衰减。这表明弹性蛋白网络可以用DFC来表征,DFC可以用来量化由于衰老等生理变化引起的结构变化。
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引用次数: 1
Tissue segmentation of MRI of the head by means of a Kohonen map 基于Kohonen图的头部MRI组织分割
S. Congorto, S. D. Penna, S. Erne
The authors developed a new method in order to automatically segment magnetic resonance images (MRIs) of the head. The main tissues, such as scalp, brain and skull, are recognised. The method is based on a Kohonen self organising feature map which performs a cluster of the image areas into three main classes. The network, after being trained, is successfully operated on the test set. The network performances do not depend on the MRI apparatus producing the images set. The network classes are properly matched and processed in order to obtain slices containing the desired tissues. The proposed method has been developed in the frame of a project for the 3-dimensional reconstruction of selected surfaces.
提出了一种自动分割头部核磁共振图像的新方法。主要的组织,如头皮、大脑和头骨,是可以识别的。该方法基于Kohonen自组织特征映射,将图像区域聚类为三个主要类别。网络经过训练后,在测试集上运行成功。网络性能不依赖于产生图像集的MRI设备。适当地匹配和处理网络类,以获得包含所需组织的切片。所提出的方法是在一个项目的框架内开发的,用于选定曲面的三维重建。
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引用次数: 8
Novel all-silicon sensor structure with integrated poly-Si electrodes 集成多晶硅电极的新型全硅传感器结构
L. Montelius, T. Ling, J. Tegenfeldt
The interest in miniaturization of modern chemical and medical sensors is steadily increasing. However, when employing methods and fabrication procedures especially developed for microelectronics, one may encounter new and unpredictable problems for applications in aqueous media. For instance, in microelectronics often a dual metal layer system is employed for making electrical contacts. In a solution such a contact may result in galvanic reactions and/or may dissolve in the cleaning agents used for sterilization of medical devices. To address such issues the authors have employed an all-silicon based process technology for fabrication of sturdy and reliable devices with integrated poly-Silicon electrodes that tolerate most chemical environments. In this presentation the authors report on the first results using such electrodes. A comparative study between identical poly-Si and Aluminium electrodes was made in order to investigate the usefulness of poly-Si electrodes. The authors also demonstrate the nice possibility to use well-documented methods for surface modifications using silane coupling chemistry. The authors believe this added benefit for the silicon based electrodes of easy surface modification processes, as compared with metal electrodes, to be extremely valuable for the development of accurate and tailored sensor structures for specific applications.
对现代化学和医学传感器小型化的兴趣正在稳步增长。然而,当采用专门为微电子开发的方法和制造程序时,在水介质中的应用可能会遇到新的和不可预测的问题。例如,在微电子学中,通常采用双金属层系统来制造电触点。在溶液中,这种接触可能导致电反应和/或溶解在用于医疗器械灭菌的清洗剂中。为了解决这些问题,作者采用了全硅基工艺技术来制造坚固可靠的设备,该设备具有集成的多晶硅电极,可以承受大多数化学环境。在这次演讲中,作者报告了使用这种电极的第一个结果。对相同的多晶硅电极和铝电极进行了对比研究,以考察多晶硅电极的实用性。作者还证明了很好的可能性,使用良好的记录方法,表面改性使用硅烷偶联化学。作者认为,与金属电极相比,硅基电极易于表面修饰过程的这一额外优势,对于开发用于特定应用的精确和定制传感器结构是非常有价值的。
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引用次数: 0
Low-cost active electrode improves the resolution in biopotential recordings 低成本的有源电极提高了生物电位记录的分辨率
A. C. MettingVanRijn, Anthony, Kuiper, Taco E. Dankers, Cees, Grimbergen
The accepted models of the origin of interference in body surface potential recordings predict that it would be advantageous to perform signal amplification on the electrode. A suitable circuit for a miniature biopotential amplifier to be manufactured in thick-film technology is described. A prototype series of active electrodes was produced and tested. The high immunity to interference resulted in ECG and EEG recordings of a very high quality.
体表电位记录干扰来源的公认模型预测,在电极上进行信号放大是有利的。介绍了一种适用于用厚膜技术制造的微型生物电位放大器的电路。制作并测试了一系列活性电极的原型。对干扰的高免疫力使心电图和脑电图记录的质量非常高。
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引用次数: 102
Validation of tissue segmentation based on 3D feature map in an animal model of a brain tumor 基于三维特征图的脑肿瘤动物模型组织分割方法的验证
S. Vinitski, F. Mohamed, K. Khalili, J. Gordon, M. Curtis, R. Knobler, C. Gonzalez, J. Mack
The purpose of this study was to validate our tissue segmentation technique by comparing its results with the composition of living biological tissues. A multispectral approach with three inputs was used. Volumetric MR images were obtained with steady state free procession, gradient echo, with RF spoiling and inversion recovery gradient echo techniques. The animal model used was brain tumors in hamsters. Immediately after imaging, animals were sacrificed and underwent thorough histological examination. Pre-segmentation image processing included our technique for correction of image non-uniformity, application of non-linear diffusion type filters, and, after collecting training points, cluster optimization. Finally, k-NN segmentation was used and a stack of color-coded segmented images was created. Results indicated that good quality of a small subject, such as a hamster brain MRI, can be obtained. Secondly, pre-processing steps vastly improved the results of segmentation-in particular, sharpness. We were able to identify up to eleven tissues. Most importantly, our findings were in full accord with histological exams.
本研究的目的是通过将其结果与活体生物组织的组成进行比较来验证我们的组织分割技术。采用了具有三个输入的多光谱方法。采用稳态自由处理、梯度回波、射频破坏和反演恢复梯度回波技术获得体磁共振图像。使用的动物模型是仓鼠的脑瘤。成像后立即处死动物并进行彻底的组织学检查。预分割图像处理包括我们的图像非均匀性校正技术,非线性扩散型滤波器的应用,以及收集训练点后的聚类优化。最后,使用k-NN分割,创建颜色编码的分割图像堆栈。结果表明,该方法可以获得高质量的小对象,如仓鼠脑MRI。其次,预处理步骤极大地改善了分割的结果,特别是清晰度。我们能够识别多达十一种组织。最重要的是,我们的发现与组织学检查完全一致。
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引用次数: 3
An efficient implementation of the PI subspace state-space system identification algorithm 一种有效实现PI子空间状态空间系统辨识的算法
D. Westwick, R. Kearney, M. Verhaegen
Subspace based methods for linear system identification are robust, require few a priori assumption's, and impose minimal restrictions on the type of input used to probe the system. However, due to their excessive computational and storage requirements, they have seen only limited application within biomedical engineering. In this paper, the authors develop a fast, low memory variant of an instrumental variable subspace method. Monte-Carlo simulations demonstrate the acceleration achieved by this new implementation.
基于子空间的线性系统辨识方法是鲁棒的,需要很少的先验假设,并且对用于探测系统的输入类型施加最小的限制。然而,由于它们对计算和存储的要求过高,它们在生物医学工程中的应用有限。在本文中,作者开发了一种快速、低内存的工具变量子空间方法的变体。蒙特卡洛仿真证明了这种新实现实现的加速效果。
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引用次数: 2
MRI feature extraction using genetic algorithms 基于遗传算法的MRI特征提取
R. Velthuizen, L. Hall, L. Clarke
Traditional machine vision techniques apply a feature extraction step before any classification, but this is not commonly done for magnetic resonance images. In this study the authors propose to discover optimal feature extractors for MRI to increase segmentation accuracy. Genetic algorithms are applied using a fitness function based on known class labels, and on a fitness function that can be applied to data without ground truth. Both fitness functions allow the discovery of good features, that can be applied outside the data that was used for the search. An increase in the tumor true positive rate for an MRI volume using fuzzy c-means (FCM) was found from 78.7% to 91.3% of all tumor pixels with constant false negative rate. This approach may lead to significantly improved MRI segmentation, which is needed in particular for multicenter trials for brain tumor treatment.
传统的机器视觉技术在任何分类之前应用特征提取步骤,但这通常不用于磁共振图像。在这项研究中,作者提出了寻找最佳的MRI特征提取器,以提高分割精度。遗传算法使用基于已知类标签的适应度函数,以及可以应用于没有基础真理的数据的适应度函数来应用。这两个适应度函数都允许发现好的特征,这些特征可以应用于用于搜索的数据之外。在假阴性率恒定的情况下,使用模糊c均值(FCM)的MRI体积的肿瘤真阳性率从78.7%增加到91.3%。这种方法可能会显著改善MRI分割,这在脑肿瘤治疗的多中心试验中尤其需要。
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引用次数: 13
Development of virtual reality (VR) system to evaluate human 3D spatial cognition [eye movements analysis] 评估人类三维空间认知的虚拟现实(VR)系统开发[眼动分析]
H. Nakamura, T. Aoki, F. Okuyama, H. Tanaka
Human 3D spatial cognition is the most crucial factor to evaluate Virtual Reality (VR) environments. In order to evaluate this property the authors observed an eye-movement to clarify the difference between a real environment and a virtual one (VR). The authors conducted a psychophysical experiment using three real objects (cube, wedge and pyramid). The task for a subject is to determine the kind of object which is presented in front of him. The latency and trajectory of eye-movement until the subject realized the object shape were measured by an Eye Mark Recorder (EMR 600 by NAC Co.). The shortest response time was observed in the case of the cubic object. Characteristics for the trajectory of eye-movement were as follows: (1) Scanning areas were not spread uniformly over the object. (2) Trajectories of eye-movement were rather concentrated on specific areas of the object such as edges and corners.
人的三维空间认知能力是评价虚拟现实(VR)环境的最关键因素。为了评估这一特性,作者观察了眼球运动,以澄清真实环境和虚拟环境(VR)之间的区别。作者用三种实物(立方体、楔形和金字塔)进行了心理物理实验。受试者的任务是确定呈现在他面前的物体的种类。用NAC公司的emr600眼痕记录仪测量被试在意识到物体形状之前的眼动潜伏期和轨迹。在立方体物体的情况下,观察到最短的响应时间。眼动轨迹的特点是:(1)扫描区域在物体上分布不均匀。(2)眼球运动轨迹集中在物体的特定区域,如边缘和角落。
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引用次数: 0
Fiber-optic polarimetric temperature sensor for characterizing a 900 MHz TEM cell used in bioeffects dosimetry studies 用于表征生物效应剂量学研究中使用的900 MHz TEM细胞的光纤偏振温度传感器
J. Rasmussen, B. Scholl, T. Gellekum, H. Schmitt
The primary goal in the development of an exposition chamber for bioeffects dosimetry studies is the exact knowledge of the electromagnetic field components inside the biological sample. Measuring is not possible using metallic field probes. This paper describes a transversal electromagnetic (TEM) cell suitable for bioeffects dosimetry studies at 900 MHz and the design of a fiber-optic polarimetric temperature sensor which is used to measure the specific absorption rate (SAR). Using this sensor a temperature change lower than 0.003/spl deg/C is detectable. By simulating the whole TEM cell and comparing; the results with the measured SAR at certain points inside the liquid biological sample one is able to determine the electromagnetic field components.
开发用于生物效应剂量学研究的暴露室的主要目标是准确了解生物样品内的电磁场成分。使用金属场探头测量是不可能的。本文介绍了一种适用于900兆赫生物效应剂量学研究的横向电磁(TEM)细胞和一种用于测量比吸收率(SAR)的光纤偏振温度传感器的设计。使用该传感器可以检测到低于0.003/spl℃的温度变化。通过对整个TEM细胞的模拟和比较;利用液体生物样品内某一点的SAR测量结果,可以确定电磁场的分量。
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引用次数: 2
A medical devices database on CD-ROM 光盘上的医疗设备数据库
C. van Nimwegen, C. Zeelenberg, W. Cavens
A medical devices database is described, which is aimed to support clinical engineers and others involved in medical instrumentation in purchasing medical devices and in solving application problems. The database comprises information about the local market supply, characteristics and features, evaluation and hazard reports, standards etc. concerning medical devices. The database is published on CD-ROM under the name MedPro by TNO Prevention and Health in The Netherlands. Present users appreciate the very friendly user interface and the clear presentation of data.
描述了一个医疗设备数据库,其目的是支持临床工程师和其他涉及医疗仪器的人员购买医疗设备和解决应用问题。该数据库包括有关医疗器械的本地市场供应、特点和特点、评估和危害报告、标准等信息。该数据库由荷兰TNO预防和卫生组织以MedPro的名义以光盘出版。当前用户喜欢非常友好的用户界面和清晰的数据表示。
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引用次数: 0
期刊
Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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