首页 > 最新文献

Proceedings of the Society for Experimental Biology and Medicine最新文献

英文 中文
INDOCYANINE GREEN-PLASMA HALF TIME CLEARANCE (T 1/2) IN NORMAL BEAGLES. 正常比格犬的吲哚菁绿-血浆半衰期清除率(t1 /2)。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30140
W J KRASAVAGE, S M MICHAELSON
Summary 1. The mean plasma clearance half time of indocyanine green (ICG) was found to be 5.6 ± 0,8§ minutes in male beagles, and 7.0 ± 1.48 in female beagles, 2. Female dogs in this study cleared ICG significantly more slowly than the males. 3. Plasma volume estimated using ICG is 3 7.7 ± 6.0 ml/kg. This figure agrees with 37.5 ± 6.1 ml/kg found using radioiron (Fe-59).
{"title":"INDOCYANINE GREEN-PLASMA HALF TIME CLEARANCE (T 1/2) IN NORMAL BEAGLES.","authors":"W J KRASAVAGE, S M MICHAELSON","doi":"10.3181/00379727-119-30140","DOIUrl":"https://doi.org/10.3181/00379727-119-30140","url":null,"abstract":"Summary 1. The mean plasma clearance half time of indocyanine green (ICG) was found to be 5.6 ± 0,8§ minutes in male beagles, and 7.0 ± 1.48 in female beagles, 2. Female dogs in this study cleared ICG significantly more slowly than the males. 3. Plasma volume estimated using ICG is 3 7.7 ± 6.0 ml/kg. This figure agrees with 37.5 ± 6.1 ml/kg found using radioiron (Fe-59).","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"215-8"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40796824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
CHROMOSOME CHANGES IN PPLO-INFECTED FL HUMAN AMNION CELLS. pplo感染人羊膜细胞的染色体变化。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30145
J FOGH, H FOGH
Summary Characteristic chromosome changes were observed in PPLO-infected FL human amnion cells. These changes included a gradual reduction in chromosome numbers, increase in chromosome aberrations, and the appearance of 3 new varieties. Although some of the aberrations appeared early after infection, most changes developed slowly, over a period of several months.
{"title":"CHROMOSOME CHANGES IN PPLO-INFECTED FL HUMAN AMNION CELLS.","authors":"J FOGH, H FOGH","doi":"10.3181/00379727-119-30145","DOIUrl":"https://doi.org/10.3181/00379727-119-30145","url":null,"abstract":"Summary Characteristic chromosome changes were observed in PPLO-infected FL human amnion cells. These changes included a gradual reduction in chromosome numbers, increase in chromosome aberrations, and the appearance of 3 new varieties. Although some of the aberrations appeared early after infection, most changes developed slowly, over a period of several months.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"233-8"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40796829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 102
SOME ENDOGENOUS PARATHYROID HORMONE EFFECTS MANIFESTED BY BONE IN VITRO. 一些内源性甲状旁腺激素的作用表现在骨的体外。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30104
C W COOPER, C W YATES, R V TALMAGE
Summary A system of bone incubation is described in which pooled rat serum was used for the incubation of femoral fragments. The following results were observed: 1. In vitro calcium and Ca45 equilibration studies on metaphyseal and diaphyseal femoral rat bone indicate that metaphyseal bone equilibrates at a higher level than does diaphyseal bone. 2. Incubated bone taken from parathyroid intact animals maintains higher calcium levels in vitro than bone from parathyroidectomized rats; this is also the case for Ca45 injected longer than 24 hours before sacrifice and subsequent incubation. If the Ca45 is injected less than 24 hours before sacrifice, the same amount of radioactivity is released into the medium for both intact and parathyroidectomized groups. Dead bone, however, always releases less radioactivity than live bone. 3. These studies indicate that endogenous parathyroid hormonal effects are detectable when bone is removed from parathyroid intact rats and incubated. These effects are exerted through an influence on cellular mediated processes; however, bone from parathyroidectomized rats also maintains media calcium levels partly through energy requiring processes. 4. Evidence presented illustrates 2 distinct processes of bone salt removal exist, one of which is influenced by endogenous parathyroid hormone. Data also imply that diaphyseal (compact) bone may be the primary site of parathyroid hormone influences on calcium homeostasis.
{"title":"SOME ENDOGENOUS PARATHYROID HORMONE EFFECTS MANIFESTED BY BONE IN VITRO.","authors":"C W COOPER, C W YATES, R V TALMAGE","doi":"10.3181/00379727-119-30104","DOIUrl":"https://doi.org/10.3181/00379727-119-30104","url":null,"abstract":"Summary A system of bone incubation is described in which pooled rat serum was used for the incubation of femoral fragments. The following results were observed: 1. In vitro calcium and Ca45 equilibration studies on metaphyseal and diaphyseal femoral rat bone indicate that metaphyseal bone equilibrates at a higher level than does diaphyseal bone. 2. Incubated bone taken from parathyroid intact animals maintains higher calcium levels in vitro than bone from parathyroidectomized rats; this is also the case for Ca45 injected longer than 24 hours before sacrifice and subsequent incubation. If the Ca45 is injected less than 24 hours before sacrifice, the same amount of radioactivity is released into the medium for both intact and parathyroidectomized groups. Dead bone, however, always releases less radioactivity than live bone. 3. These studies indicate that endogenous parathyroid hormonal effects are detectable when bone is removed from parathyroid intact rats and incubated. These effects are exerted through an influence on cellular mediated processes; however, bone from parathyroidectomized rats also maintains media calcium levels partly through energy requiring processes. 4. Evidence presented illustrates 2 distinct processes of bone salt removal exist, one of which is influenced by endogenous parathyroid hormone. Data also imply that diaphyseal (compact) bone may be the primary site of parathyroid hormone influences on calcium homeostasis.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"81-8"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40798138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
INOTROPIC EFFECTS OF OUABAIN ON RABBIT LEFT ATRIA IN PRESENCE OF BETA-ADRENERGIC BLOCKING DRUGS. β -肾上腺素能阻断药物作用下乌阿拜对兔左心房的肌力作用。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30158
J V LEVY, V RICHARDS
Summary The positive inotropic effects of ouabain on electrically driven rabbit left atrial preparations was studied in the presence of 3 drugs known to be potent and specific beta-adrenergic receptor antagonists (pronethalol, propranolol and MJ-1999). Ouabain alone (6.9 × 10-7 M) produced a highly significant increase in contraction force compared to untreated controls. Pronethalol (3.76 × 10-6 M) and propranolol (1.35 × 10-6 M) were found to produce significant decreases in contraction force. The methanesulfonanilide substituted isopropylphenylethylamine (MJ-1999) had no significant effects on contraction force in a concentration of 1.3 × 10-5 M. Administering ouabain after pretreatment with and in the presence of either pronethalol, propranolol, or MJ-1999 failed to modify significantly the normal positive inotropic effect of the glycoside. Therefore, no evidence was found to indicate that beta-adrenergic receptor blockade could prevent the positive inotropic effect of ouabain on isolated rabbit left atria.
{"title":"INOTROPIC EFFECTS OF OUABAIN ON RABBIT LEFT ATRIA IN PRESENCE OF BETA-ADRENERGIC BLOCKING DRUGS.","authors":"J V LEVY, V RICHARDS","doi":"10.3181/00379727-119-30158","DOIUrl":"https://doi.org/10.3181/00379727-119-30158","url":null,"abstract":"Summary The positive inotropic effects of ouabain on electrically driven rabbit left atrial preparations was studied in the presence of 3 drugs known to be potent and specific beta-adrenergic receptor antagonists (pronethalol, propranolol and MJ-1999). Ouabain alone (6.9 × 10-7 M) produced a highly significant increase in contraction force compared to untreated controls. Pronethalol (3.76 × 10-6 M) and propranolol (1.35 × 10-6 M) were found to produce significant decreases in contraction force. The methanesulfonanilide substituted isopropylphenylethylamine (MJ-1999) had no significant effects on contraction force in a concentration of 1.3 × 10-5 M. Administering ouabain after pretreatment with and in the presence of either pronethalol, propranolol, or MJ-1999 failed to modify significantly the normal positive inotropic effect of the glycoside. Therefore, no evidence was found to indicate that beta-adrenergic receptor blockade could prevent the positive inotropic effect of ouabain on isolated rabbit left atria.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"278-81"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40796562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
SURVIVAL OF TYPE 1 AND TYPE 3 POLIO VACCINE VIRUS IN BLOWFLIES. (PHAENICIA SERICATA) AT 40 DEGREE C. 1型和3型脊髓灰质炎疫苗病毒在苍蝇体内的存活率。(绢茧蜂属)在摄氏40度。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30114
K H DAVE, R C WALLIS
Discussion and summary Interest in the behavior of polioviruses in flies stems from two factors: (1) the potential importance of these insects as vectors of the virus under certain circumstances; and (2) the possibility that if polioviruses multiply in flies, they may undergo mutation during the process. Investigations of the genetic stability of polioviruses have been carried out largely in connection with the use of attenuated vaccine strains as immunizing agents for humans. It is apparent that wild virulent strains multiply readily at 40°C, while attenuated strains, either naturally occurring or laboratory manipulated vaccine strains, do not. In tropical areas, and in temperate climates during the summer, flies are exposed to high environmental temperatures at least for some time during the day. If this occurs while they are hosts of polioviruses, and if polioviruses undergo multiplication in flies, it is possible that attenuated strains might undergo changes in their genetic characters, with a shift toward the pattern of greater virulence. The results of the present investigation, which was undertaken to explore this possibility, indicate that under the conditions tested there was no evidence of multiplication in type 1 or type 3 attenuated vaccine strains (Sabin) in the fly species Phaenicia sericata. Poliovirus was recovered in gradually diminishing quantities for as long as 15 days from flies which had been fed type 1 virus and for at least 13 days from those which had received type 3. When certain genetic characters of the virus strains isolated from 2 to 15 days after virus feeding were compared with those of the type 1 and 3 vaccine strains, they were found to be identical; all isolates tested proved to be rct/40°C negative and vaccine-like in the intratypic serodifferentiation test of McBride. Thus the results do not provide quantitative evidence for poliovirus multiplication in the fly Phaenicia sericata, nor was it possible to demonstrate any shift in genetic characters suggesting changes toward a pattern of more virulent strains of virus.
{"title":"SURVIVAL OF TYPE 1 AND TYPE 3 POLIO VACCINE VIRUS IN BLOWFLIES. (PHAENICIA SERICATA) AT 40 DEGREE C.","authors":"K H DAVE, R C WALLIS","doi":"10.3181/00379727-119-30114","DOIUrl":"https://doi.org/10.3181/00379727-119-30114","url":null,"abstract":"Discussion and summary Interest in the behavior of polioviruses in flies stems from two factors: (1) the potential importance of these insects as vectors of the virus under certain circumstances; and (2) the possibility that if polioviruses multiply in flies, they may undergo mutation during the process. Investigations of the genetic stability of polioviruses have been carried out largely in connection with the use of attenuated vaccine strains as immunizing agents for humans. It is apparent that wild virulent strains multiply readily at 40°C, while attenuated strains, either naturally occurring or laboratory manipulated vaccine strains, do not. In tropical areas, and in temperate climates during the summer, flies are exposed to high environmental temperatures at least for some time during the day. If this occurs while they are hosts of polioviruses, and if polioviruses undergo multiplication in flies, it is possible that attenuated strains might undergo changes in their genetic characters, with a shift toward the pattern of greater virulence. The results of the present investigation, which was undertaken to explore this possibility, indicate that under the conditions tested there was no evidence of multiplication in type 1 or type 3 attenuated vaccine strains (Sabin) in the fly species Phaenicia sericata. Poliovirus was recovered in gradually diminishing quantities for as long as 15 days from flies which had been fed type 1 virus and for at least 13 days from those which had received type 3. When certain genetic characters of the virus strains isolated from 2 to 15 days after virus feeding were compared with those of the type 1 and 3 vaccine strains, they were found to be identical; all isolates tested proved to be rct/40°C negative and vaccine-like in the intratypic serodifferentiation test of McBride. Thus the results do not provide quantitative evidence for poliovirus multiplication in the fly Phaenicia sericata, nor was it possible to demonstrate any shift in genetic characters suggesting changes toward a pattern of more virulent strains of virus.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"121-4"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40799769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
INFLUENCE OF PERITONEAL INFLAMMATORY EXUDATE ON DEVELOPMENT OF A TRANSPLANTABLE MOUSE ASCITES TUMOR. 腹膜炎性渗出物对可移植小鼠腹水肿瘤发展的影响。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30111
G BARSKI, J BELEHRADEK, J KAWAMATA
Summary Three daily peritoneal injections of 1:1000 glycogen solution induced in mice, during at least 10 days, a state of relative resistance to intraperitoneal but not subcutaneous inoculation of homotransplantable dL-46 ascites tumor cells. Removal of excess macrophages by peritoneal washing or their transfer to untreated mice did not influence the development of dL-46 ascites. Furthermore, elaboration of specific immune reaction by intraperitoneal inoculation of irradiated cells was not enhanced in glycogen treated mice.
{"title":"INFLUENCE OF PERITONEAL INFLAMMATORY EXUDATE ON DEVELOPMENT OF A TRANSPLANTABLE MOUSE ASCITES TUMOR.","authors":"G BARSKI, J BELEHRADEK, J KAWAMATA","doi":"10.3181/00379727-119-30111","DOIUrl":"https://doi.org/10.3181/00379727-119-30111","url":null,"abstract":"Summary Three daily peritoneal injections of 1:1000 glycogen solution induced in mice, during at least 10 days, a state of relative resistance to intraperitoneal but not subcutaneous inoculation of homotransplantable dL-46 ascites tumor cells. Removal of excess macrophages by peritoneal washing or their transfer to untreated mice did not influence the development of dL-46 ascites. Furthermore, elaboration of specific immune reaction by intraperitoneal inoculation of irradiated cells was not enhanced in glycogen treated mice.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40885492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
VINBLASTINE EFFECT ON NUCLEIC ACIDS AND RIBONUCLEASE OF LUMPHOID TISSUE. 长春碱对瘤样组织核酸及核糖核酸酶的影响。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30113
P H WIERNIK, R M MACLEOD
Summary The RNA concentration and ribonuclease activity in rat thymus were decreased by injection of vinblastine. The same results were noted in both the corticoid sensitive and resistant strains of mouse lymphosarcoma P1798. An apparent increase in DNA concentration was noted in rat thymus and corticoid-sensitive P1798. No change in DNA concentration was noted in the corti-coid-resistant tumor.
{"title":"VINBLASTINE EFFECT ON NUCLEIC ACIDS AND RIBONUCLEASE OF LUMPHOID TISSUE.","authors":"P H WIERNIK, R M MACLEOD","doi":"10.3181/00379727-119-30113","DOIUrl":"https://doi.org/10.3181/00379727-119-30113","url":null,"abstract":"Summary The RNA concentration and ribonuclease activity in rat thymus were decreased by injection of vinblastine. The same results were noted in both the corticoid sensitive and resistant strains of mouse lymphosarcoma P1798. An apparent increase in DNA concentration was noted in rat thymus and corticoid-sensitive P1798. No change in DNA concentration was noted in the corti-coid-resistant tumor.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"118-20"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40885494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
PRELIMINARY COMMUNICATION ON THE SURVIVAL, THE SITES HARBORING VIRUS AND GENETIC STABILITY OF POLIOVIRUS IN COCKROACHES. 关于小儿麻痹症病毒在蜚蠊中的生存、病毒窝点及遗传稳定性的初步通讯。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30115
K H DAVE, R C WALLIS
Summary Sabin's attenuated strain of poliovirus type 3 persisted in cockroaches (Blaberus discoidalis) after experimental infection for as long as 51 days. No evidence was obtained indicating multiplication of the virus. Rather, the pattern was one of mechanical carriage of the virus with a gradual decline in titre. It was possible to recover virus only from the gastrointestinal tract of roaches dissected 27 days after infection but not from nerve trunk or other parts of the body of the roaches.
{"title":"PRELIMINARY COMMUNICATION ON THE SURVIVAL, THE SITES HARBORING VIRUS AND GENETIC STABILITY OF POLIOVIRUS IN COCKROACHES.","authors":"K H DAVE, R C WALLIS","doi":"10.3181/00379727-119-30115","DOIUrl":"https://doi.org/10.3181/00379727-119-30115","url":null,"abstract":"Summary Sabin's attenuated strain of poliovirus type 3 persisted in cockroaches (Blaberus discoidalis) after experimental infection for as long as 51 days. No evidence was obtained indicating multiplication of the virus. Rather, the pattern was one of mechanical carriage of the virus with a gradual decline in titre. It was possible to recover virus only from the gastrointestinal tract of roaches dissected 27 days after infection but not from nerve trunk or other parts of the body of the roaches.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"124-6"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40885495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
TRANSFER OF GAMMA GLOBULIN FROM MOTHER TO OFFSPRING IN MINK. 水貂的γ球蛋白从母体传给后代。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30117
D D PORTER
Summary Newborn mink have no detectable gamma globulin, and acquire gamma globulin from the mother via the colostrum and milk. Gamma globulin concentration in the colostrum was less than that of the maternal serum.
{"title":"TRANSFER OF GAMMA GLOBULIN FROM MOTHER TO OFFSPRING IN MINK.","authors":"D D PORTER","doi":"10.3181/00379727-119-30117","DOIUrl":"https://doi.org/10.3181/00379727-119-30117","url":null,"abstract":"Summary Newborn mink have no detectable gamma globulin, and acquire gamma globulin from the mother via the colostrum and milk. Gamma globulin concentration in the colostrum was less than that of the maternal serum.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"131-3"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40885498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
BODY AND MUSCLE WEIGHT DEPRESSING EFFECTS AND THYMOLYTIC POTENCIES OF GLUCOCORTICOIDS IN THE RAT. 糖皮质激素对大鼠身体和肌肉重量的抑制作用和胸腺溶解作用。
Pub Date : 1965-05-01 DOI: 10.3181/00379727-119-30120
G TONELLI, R PARTRIDGE, I RINGLER
Summary The effects of hydrocortisone, prednisolone, methylprednisolone, dexamethasone or triamcinolone on body weights, the weights of the rectus femoris, triceps brachialis and gastrocnemius muscles and food consumption were studied in normal male rats, weighing 87–111 g. Subcutaneous administration of the aforementioned glucocorticoids, once a day for 10 consecutive days, elicited a reduction in body weights, muscle weights and food consumption which appeared roughly proportional to the relative thymolytic potency of each glucocorticoid. From pair-feeding experiments, it was apparent that the reduction in food consumption accounted for 53–65% of the total body weight losses. Muscle weight losses were similarly affected. It was concluded that glucocorticoids have similar quantitative effects on body and muscle weights of the rat if administered at equipotent thymolytic doses.
{"title":"BODY AND MUSCLE WEIGHT DEPRESSING EFFECTS AND THYMOLYTIC POTENCIES OF GLUCOCORTICOIDS IN THE RAT.","authors":"G TONELLI, R PARTRIDGE, I RINGLER","doi":"10.3181/00379727-119-30120","DOIUrl":"https://doi.org/10.3181/00379727-119-30120","url":null,"abstract":"Summary The effects of hydrocortisone, prednisolone, methylprednisolone, dexamethasone or triamcinolone on body weights, the weights of the rectus femoris, triceps brachialis and gastrocnemius muscles and food consumption were studied in normal male rats, weighing 87–111 g. Subcutaneous administration of the aforementioned glucocorticoids, once a day for 10 consecutive days, elicited a reduction in body weights, muscle weights and food consumption which appeared roughly proportional to the relative thymolytic potency of each glucocorticoid. From pair-feeding experiments, it was apparent that the reduction in food consumption accounted for 53–65% of the total body weight losses. Muscle weight losses were similarly affected. It was concluded that glucocorticoids have similar quantitative effects on body and muscle weights of the rat if administered at equipotent thymolytic doses.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"136-42"},"PeriodicalIF":0.0,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40885501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
期刊
Proceedings of the Society for Experimental Biology and Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1