N. N. Brandt, E. Travkina, E. Mikhal'chik, A. Chikishev
Increasing interest in spectroscopic studies of human hair raises the question about the accuracy of measurement of their spectra and requires optimisation of experimental facilities. An original method of obtaining transverse hair sections without using a microtome and chemical influence is proposed. The results obtained by confocal Raman microspectroscopy of human hair differently oriented with respect to the optical axis of the measuring setup are compared. It is shown that, in addition to expected changes in the spectra measured at different distances from the hair periphery in the direction to its centre, the spectra measured in the case of hair excitation perpendicular and parallel to its axis are also considerably different.
{"title":"Influence of the measurement configuration on the results of Raman microspectroscopy of human hair","authors":"N. N. Brandt, E. Travkina, E. Mikhal'chik, A. Chikishev","doi":"10.1070/qel17973","DOIUrl":"https://doi.org/10.1070/qel17973","url":null,"abstract":"Increasing interest in spectroscopic studies of human hair raises the question about the accuracy of measurement of their spectra and requires optimisation of experimental facilities. An original method of obtaining transverse hair sections without using a microtome and chemical influence is proposed. The results obtained by confocal Raman microspectroscopy of human hair differently oriented with respect to the optical axis of the measuring setup are compared. It is shown that, in addition to expected changes in the spectra measured at different distances from the hair periphery in the direction to its centre, the spectra measured in the case of hair excitation perpendicular and parallel to its axis are also considerably different.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79869461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. V. Belikov, S. Smirnov, Yuriy Batov, A. B. Gubin, Yu. B. Pirozhkov, E. Boiko, M. Nemsitsveridze
Laser extraction of a model porcine eye cataract has been performed for the first time in an in vitro experiment using a 1.54-μm Yb, Er : glass laser generating bursts of microsecond pulses. We used effective pulse repetition rates from 36 to 75 Hz and average laser output powers from 3.9 to 5.25 W. The results demonstrate for the first time that, at an effective pulse repetition rate of 45 Hz, burst repetition rate of 15 Hz, three microsecond pulses per burst, and a burst energy from 260 to 265 mJ, the laser step duration in cataract extraction is 130 ± 10 s, which is comparable to the ultrasonic phacoemulsification and laser extraction time in the case of a Nd : YAG laser emitting at 1.44 μm. Acoustometry and high speed video recording of hydroacoustic processes accompanying interaction of water with 1.54-μm radiation from the Yb, Er : glass laser generating bursts of microsecond pulses have made it possible for the first time to detect overlap of hydroacoustic processes at the pulse spacing in bursts reduced to under 700 μs. In the case of overlap of hydroacoustic processes, despite the increase in average power and effective pulse repetition rate, acoustic wave generation is ineffective because pulses propagate through bubbles formed in the water. Laser cataract extraction is shown to be most effective at a lower average power, lower effective pulse repetition rate, and burst pulse spacing of 850 ± 10 μs.
{"title":"In vitro study of cataract extraction by bursts of microsecond 1.54-μm laser pulses","authors":"A. V. Belikov, S. Smirnov, Yuriy Batov, A. B. Gubin, Yu. B. Pirozhkov, E. Boiko, M. Nemsitsveridze","doi":"10.1070/QEL17959","DOIUrl":"https://doi.org/10.1070/QEL17959","url":null,"abstract":"Laser extraction of a model porcine eye cataract has been performed for the first time in an in vitro experiment using a 1.54-μm Yb, Er : glass laser generating bursts of microsecond pulses. We used effective pulse repetition rates from 36 to 75 Hz and average laser output powers from 3.9 to 5.25 W. The results demonstrate for the first time that, at an effective pulse repetition rate of 45 Hz, burst repetition rate of 15 Hz, three microsecond pulses per burst, and a burst energy from 260 to 265 mJ, the laser step duration in cataract extraction is 130 ± 10 s, which is comparable to the ultrasonic phacoemulsification and laser extraction time in the case of a Nd : YAG laser emitting at 1.44 μm. Acoustometry and high speed video recording of hydroacoustic processes accompanying interaction of water with 1.54-μm radiation from the Yb, Er : glass laser generating bursts of microsecond pulses have made it possible for the first time to detect overlap of hydroacoustic processes at the pulse spacing in bursts reduced to under 700 μs. In the case of overlap of hydroacoustic processes, despite the increase in average power and effective pulse repetition rate, acoustic wave generation is ineffective because pulses propagate through bubbles formed in the water. Laser cataract extraction is shown to be most effective at a lower average power, lower effective pulse repetition rate, and burst pulse spacing of 850 ± 10 μs.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90057260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Ignat'eva, O. Zakharkina, A. Sviridov, K. V. Mazaishvili, A. Shekhter
Experiments modelling endovenous laser obliteration (EVLO) are performed. As a result, laser radiation powers P c at which collagen denaturation, tissue necrosis, and vasa vasorum destruction occur throughout the entire venous-wall thickness and, at the same time, the surrounding tissues are not subjected to unnecessary heating, are found. The main criterion for determining P c is the achievement of 100 % denaturation of venous-wall proteins, confirmed by morphological and calorimetric analysis. The P c values for laser wavelengths of 1.47, 1.56, and 1.68 μm are found to be 6.0 ± 0.2, 5.0 ± 0.2, and 6.0 ± 0.2 W, respectively. It is established for all wavelengths in use that the temperature of the external venous-wall surface reaches 91 ± 2 °C at the corresponding power P c. We relate the dependence of P c on the radiation wavelength to the formation of a coagulum on the optical fibre tip moving through a blood-filled vessel. The achievement of temperature necessary for coagulum formation is determined by the simultaneously occurring processes of energy absorption and its dissipation in the form of heat. These processes become more intense with an increase in the absorption coefficient of the medium. A mechanism is proposed to explain the relationship between the P c value and laser wavelength, based on the influence of the absorption coefficient of medium (blood) on the temperature near the fibre tip.
{"title":"Estimation of a minimum laser power with wavelengths of 1.47, 1.56, and 1.68 μm for efficient obliteration of varicose veins","authors":"N. Ignat'eva, O. Zakharkina, A. Sviridov, K. V. Mazaishvili, A. Shekhter","doi":"10.1070/qel17968","DOIUrl":"https://doi.org/10.1070/qel17968","url":null,"abstract":"Experiments modelling endovenous laser obliteration (EVLO) are performed. As a result, laser radiation powers P c at which collagen denaturation, tissue necrosis, and vasa vasorum destruction occur throughout the entire venous-wall thickness and, at the same time, the surrounding tissues are not subjected to unnecessary heating, are found. The main criterion for determining P c is the achievement of 100 % denaturation of venous-wall proteins, confirmed by morphological and calorimetric analysis. The P c values for laser wavelengths of 1.47, 1.56, and 1.68 μm are found to be 6.0 ± 0.2, 5.0 ± 0.2, and 6.0 ± 0.2 W, respectively. It is established for all wavelengths in use that the temperature of the external venous-wall surface reaches 91 ± 2 °C at the corresponding power P c. We relate the dependence of P c on the radiation wavelength to the formation of a coagulum on the optical fibre tip moving through a blood-filled vessel. The achievement of temperature necessary for coagulum formation is determined by the simultaneously occurring processes of energy absorption and its dissipation in the form of heat. These processes become more intense with an increase in the absorption coefficient of the medium. A mechanism is proposed to explain the relationship between the P c value and laser wavelength, based on the influence of the absorption coefficient of medium (blood) on the temperature near the fibre tip.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90059025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is shown that the image contrast in the air when using a microscope based on dielectric microparticles with a size of the order of wavelength can be significantly enhanced with the help microparticles that provide the formation of the radiation localisation region at an angle to the direction of radiation incidence (at an angle to the optical axis). For this purpose, a screen is placed in front of the particle, which blocks part of the incident beam, forming a photonic hook or a photonic jet (terajet) with oblique illumination in the near field.
{"title":"Terahertz microscope with oblique subwavelength illumination: design principle","authors":"O. Minin, I. Minin","doi":"10.1070/qel17958","DOIUrl":"https://doi.org/10.1070/qel17958","url":null,"abstract":"It is shown that the image contrast in the air when using a microscope based on dielectric microparticles with a size of the order of wavelength can be significantly enhanced with the help microparticles that provide the formation of the radiation localisation region at an angle to the direction of radiation incidence (at an angle to the optical axis). For this purpose, a screen is placed in front of the particle, which blocks part of the incident beam, forming a photonic hook or a photonic jet (terajet) with oblique illumination in the near field.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83771131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. A. Zyuryukina, M. E. Shvachkina, V. Kochubey, Y. Sinichkin, D. Yakovlev
Using optical coherence tomography, the scattering coefficients of collagen bundles are estimated at different levels of tissue hydration. We test the validity of a simple theoretical model of dehydration changes in the optical characteristics of a collagen bundle, which is considered as a system of parallel cylinders that model the collagen fibrils forming the bundle. The characteristics of scattering by individual scatterers are calculated using the Mie theory. To take into account the cooperative effects caused by the close packing of the scatterers, use is made of the standard packing function for a system of identical cylinders. The theoretical model also relies on a certain empirical law of changes in the hydration level of fibrils with a change in the water content in the tissue, which predetermines changes in the diameter and refractive index of fibrils during dehydration and rehydration of the tissue. It is shown that the theoretical estimates obtained using this model are in good agreement with the experimental data, which makes it possible to consider this model as reliable.
{"title":"Testing the adequacy of a simple theoretical model of dehydration optical clearing of collagen bundles: OCT measurements","authors":"O. A. Zyuryukina, M. E. Shvachkina, V. Kochubey, Y. Sinichkin, D. Yakovlev","doi":"10.1070/QEL17965","DOIUrl":"https://doi.org/10.1070/QEL17965","url":null,"abstract":"Using optical coherence tomography, the scattering coefficients of collagen bundles are estimated at different levels of tissue hydration. We test the validity of a simple theoretical model of dehydration changes in the optical characteristics of a collagen bundle, which is considered as a system of parallel cylinders that model the collagen fibrils forming the bundle. The characteristics of scattering by individual scatterers are calculated using the Mie theory. To take into account the cooperative effects caused by the close packing of the scatterers, use is made of the standard packing function for a system of identical cylinders. The theoretical model also relies on a certain empirical law of changes in the hydration level of fibrils with a change in the water content in the tissue, which predetermines changes in the diameter and refractive index of fibrils during dehydration and rehydration of the tissue. It is shown that the theoretical estimates obtained using this model are in good agreement with the experimental data, which makes it possible to consider this model as reliable.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73872991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Zhang, M. Singh, Fernando Zvietcovich, K. Larin, S. Aglyamov
The viscoelastic properties of the young and mature rabbit lenses in situ are evaluated using wave-based optical coherence elastography (OCE). Surface waves in the crystalline lens are generated using acoustic radiation force (ARF) focused inside the eyeball. Surface-wave dispersion is measured with a phase-stabilised optical coherence tomography (OCT) system. The Young's modulus and shear viscosity coefficient are quantified based on a Scholte wave model. The results show that both elasticity and viscosity are significantly different between the young and mature lenses. The Young's modulus of the lenses increased with age from 7.74 ± 1.56 kPa (young) to 15.15 ± 4.52 kPa (mature), and the shear viscosity coefficient increased from 0.55 ± 0.04 Pa s (young) and 0.86 ± 0.13 Pa s (mature). It is shown that the combination of ARF excitation, OCE imaging, and dispersion analysis enables nondestructive quantification of lenticular viscoelasticity in situ and shows promise for in vivo applications.
利用基于波的光学相干弹性成像(OCE)对原位幼兔和成熟兔晶状体的粘弹性特性进行了评价。晶状体中的表面波是利用聚焦在眼球内部的声辐射力(ARF)产生的。用相位稳定光学相干层析成像(OCT)系统测量了表面波色散。杨氏模量和剪切粘滞系数是基于一个Scholte波模型的量化。结果表明，新生晶状体和成熟晶状体的弹性和黏度均有显著差异。晶状体的杨氏模量从7.74±1.56 kPa(年轻)增加到15.15±4.52 kPa(成熟)，剪切黏度系数从0.55±0.04 Pa s(年轻)增加到0.86±0.13 Pa s(成熟)。研究表明，结合ARF激发、OCE成像和色散分析，可以对透镜体的原位粘弹性进行无损量化，并有望在体内应用。
{"title":"Age-related changes in the viscoelasticity of rabbit lens characterised by surface wave dispersion analysis","authors":"H. Zhang, M. Singh, Fernando Zvietcovich, K. Larin, S. Aglyamov","doi":"10.1070/qel17964","DOIUrl":"https://doi.org/10.1070/qel17964","url":null,"abstract":"The viscoelastic properties of the young and mature rabbit lenses in situ are evaluated using wave-based optical coherence elastography (OCE). Surface waves in the crystalline lens are generated using acoustic radiation force (ARF) focused inside the eyeball. Surface-wave dispersion is measured with a phase-stabilised optical coherence tomography (OCT) system. The Young's modulus and shear viscosity coefficient are quantified based on a Scholte wave model. The results show that both elasticity and viscosity are significantly different between the young and mature lenses. The Young's modulus of the lenses increased with age from 7.74 ± 1.56 kPa (young) to 15.15 ± 4.52 kPa (mature), and the shear viscosity coefficient increased from 0.55 ± 0.04 Pa s (young) and 0.86 ± 0.13 Pa s (mature). It is shown that the combination of ARF excitation, OCE imaging, and dispersion analysis enables nondestructive quantification of lenticular viscoelasticity in situ and shows promise for in vivo applications.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81004288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Konnikova, O. Cherkasova, T.A. Geints, E. Dizer, A. A. Man'kova, I. S. Vasilievskii, A. Butylin, Y. Kistenev, V. Tuchin, A. Shkurinov
Adhesion of the spike protein of the SARS-CoV-2 virus is studied by vibrational spectroscopy using terahertz metamaterials. The features of metastructure absorption upon the deposition of histidine, albumin, and the receptor-binding domain of the spike protein films are investigated. An original technique for quantitative assessment of the efficiency of virus adhesion on the metamaterial surfaces are proposed and experimentally tested.
{"title":"Study of adsorption of the SARS-CoV-2 virus spike protein by vibrational spectroscopy using terahertz metamaterials","authors":"M. Konnikova, O. Cherkasova, T.A. Geints, E. Dizer, A. A. Man'kova, I. S. Vasilievskii, A. Butylin, Y. Kistenev, V. Tuchin, A. Shkurinov","doi":"10.1070/qel17960","DOIUrl":"https://doi.org/10.1070/qel17960","url":null,"abstract":"Adhesion of the spike protein of the SARS-CoV-2 virus is studied by vibrational spectroscopy using terahertz metamaterials. The features of metastructure absorption upon the deposition of histidine, albumin, and the receptor-binding domain of the spike protein films are investigated. An original technique for quantitative assessment of the efficiency of virus adhesion on the metamaterial surfaces are proposed and experimentally tested.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90623836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Richter, M. Rank, A. Heinrich, H. Schneckenburger
Microscopy methods for 3D live cell imaging, including various techniques, challenges and restrictions, are described. Novel devices for application of these methods in combination with 3D printed optics are presented and discussed.
{"title":"Novel approaches in 3D live cell microscopy","authors":"V. Richter, M. Rank, A. Heinrich, H. Schneckenburger","doi":"10.1070/qel17961","DOIUrl":"https://doi.org/10.1070/qel17961","url":null,"abstract":"Microscopy methods for 3D live cell imaging, including various techniques, challenges and restrictions, are described. Novel devices for application of these methods in combination with 3D printed optics are presented and discussed.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78014883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Zavestovskaya, V. Gushchin, L. I. Russu, E. Cheshev, A. Koromyslov, I. Tupitsyn, A. A. Fronya, M. S. Grigor'eva
We report the results of the development of an experimental stand based on UVA light-emitting diodes (UVA LEDs) with radiation wavelengths of 385 and 395 nm for studying experimentally the inactivation of viruses of the coronavirus family, including SARS-CoV-2. Methodological grounds are presented for determining the inactivation dose that provides a predetermined decrease in the virus titre under the impact of UVA radiation. The effect of the diode radiation divergence on the virus photoinactivation process is investigated. It is shown that UVA LEDs can be used to reduce the virus titre by 4 orders of magnitude.
{"title":"Inactivation of coronaviruses under irradiation by UVA-range light-emitting diodes","authors":"I. Zavestovskaya, V. Gushchin, L. I. Russu, E. Cheshev, A. Koromyslov, I. Tupitsyn, A. A. Fronya, M. S. Grigor'eva","doi":"10.1070/qel17969","DOIUrl":"https://doi.org/10.1070/qel17969","url":null,"abstract":"We report the results of the development of an experimental stand based on UVA light-emitting diodes (UVA LEDs) with radiation wavelengths of 385 and 395 nm for studying experimentally the inactivation of viruses of the coronavirus family, including SARS-CoV-2. Methodological grounds are presented for determining the inactivation dose that provides a predetermined decrease in the virus titre under the impact of UVA radiation. The effect of the diode radiation divergence on the virus photoinactivation process is investigated. It is shown that UVA LEDs can be used to reduce the virus titre by 4 orders of magnitude.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82358861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Shilov, A. S. Gorshkova, A. Ivanov, V. Rumyantseva, G. Danielyan, V. Kashin
We report the results of developing a technique for theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy (PDT) in the absorption band of porphyrin. It is shown that the therapeutic effect is achieved exclusively due to PDT, without the participation of the hyperthermia process, which occurs at temperatures above 42°C. The Fluroscan gel [based on the dipotassium salt of the ytterbium complex of 2,4-di-(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP)] is used as a preparation for theranostics. The main photophysical properties and possible mechanisms of accumulation of nanosized low-toxic photosensitisers based on this compound are studied. It is shown that the Yb-DMDP compound in a DMSO solution (30 % aqueous DMSO) enhances photophysical characteristics (luminescence lifetime 5 – 10 μs, luminescence quantum yield up to 1 %, extinction coefficient ∼1.96 × 105 M−1 cm−1 at a wavelength of 398 nm). Experimental animals are used to test the proposed technique for theranostics of tumours using the Fluroscan gel and a fibre-optic laser fluorimeter.
{"title":"Theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy in the absorption band of porphyrin","authors":"I. Shilov, A. S. Gorshkova, A. Ivanov, V. Rumyantseva, G. Danielyan, V. Kashin","doi":"10.1070/QEL17966","DOIUrl":"https://doi.org/10.1070/QEL17966","url":null,"abstract":"We report the results of developing a technique for theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy (PDT) in the absorption band of porphyrin. It is shown that the therapeutic effect is achieved exclusively due to PDT, without the participation of the hyperthermia process, which occurs at temperatures above 42°C. The Fluroscan gel [based on the dipotassium salt of the ytterbium complex of 2,4-di-(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP)] is used as a preparation for theranostics. The main photophysical properties and possible mechanisms of accumulation of nanosized low-toxic photosensitisers based on this compound are studied. It is shown that the Yb-DMDP compound in a DMSO solution (30 % aqueous DMSO) enhances photophysical characteristics (luminescence lifetime 5 – 10 μs, luminescence quantum yield up to 1 %, extinction coefficient ∼1.96 × 105 M−1 cm−1 at a wavelength of 398 nm). Experimental animals are used to test the proposed technique for theranostics of tumours using the Fluroscan gel and a fibre-optic laser fluorimeter.","PeriodicalId":20775,"journal":{"name":"Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90242783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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