Pub Date : 2024-09-23DOI: 10.1016/j.psyneuen.2024.107194
Kaylin E. Hill , Emilia F. Cárdenas , Eileen Yu , Regina Hammond , Kathryn L. Humphreys , Autumn Kujawa
Peripartum depression is a global health concern, characterized by mood disturbances inclusive of pregnancy through up to 12-months postpartum. Hormones play a vital role in pregnancy maintenance, fetal development, and labor and delivery and change significantly as a function of pregnancy and childbirth. However, such life sustaining changes may have consequences related to risk for peripartum depression. To date, most studies that have examined hormones in relation to peripartum depression have focused on blood or saliva sampling approaches, though hair analysis offers unique information on trajectories of hormone concentrations over more sustained periods of time (i.e., over months). The aim of this systematic review was to provide a comprehensive review of the association between hair measures of hormones (i.e., cortisol, progesterone, estrogen, and testosterone) and depression during the peripartum period. Forty-one studies were identified for inclusion. A majority of studies reported statistically null associations. Between-person studies varied widely in reported direction and magnitude of hair hormone–depression associations, most likely attributable to a wide range of methodological approaches including timing of assessments and sample size. Studies using within-person approaches observed positive coupling of cortisol concentration and symptoms across time. Most studies focused exclusively on cortisol. We recommend future research consider both stress and reproductive hormones, prioritize within-person change in hormone levels given this is a period of dramatic change, and include contextual (e.g., social support, adverse and benevolent childhood experiences, physical and psychiatric conditions) features that may modify both changes in hormones and the association between hormone levels and depression in the peripartum period.
{"title":"A systematic review of associations between hormone levels in hair and peripartum depression","authors":"Kaylin E. Hill , Emilia F. Cárdenas , Eileen Yu , Regina Hammond , Kathryn L. Humphreys , Autumn Kujawa","doi":"10.1016/j.psyneuen.2024.107194","DOIUrl":"10.1016/j.psyneuen.2024.107194","url":null,"abstract":"<div><div>Peripartum depression is a global health concern, characterized by mood disturbances inclusive of pregnancy through up to 12-months postpartum. Hormones play a vital role in pregnancy maintenance, fetal development, and labor and delivery and change significantly as a function of pregnancy and childbirth. However, such life sustaining changes may have consequences related to risk for peripartum depression. To date, most studies that have examined hormones in relation to peripartum depression have focused on blood or saliva sampling approaches, though hair analysis offers unique information on trajectories of hormone concentrations over more sustained periods of time (i.e., over months). The aim of this systematic review was to provide a comprehensive review of the association between hair measures of hormones (i.e., cortisol, progesterone, estrogen, and testosterone) and depression during the peripartum period. Forty-one studies were identified for inclusion. A majority of studies reported statistically null associations. Between-person studies varied widely in reported direction and magnitude of hair hormone–depression associations, most likely attributable to a wide range of methodological approaches including timing of assessments and sample size. Studies using within-person approaches observed positive coupling of cortisol concentration and symptoms across time. Most studies focused exclusively on cortisol. We recommend future research consider both stress and reproductive hormones, prioritize within-person change in hormone levels given this is a period of dramatic change, and include contextual (e.g., social support, adverse and benevolent childhood experiences, physical and psychiatric conditions) features that may modify both changes in hormones and the association between hormone levels and depression in the peripartum period.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107194"},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1016/j.psyneuen.2024.107189
Stephanie M. Koning , Emma K. Adam , Amita Kapoor , Thomas W. McDade
Armed conflict, displacement, and related violence is escalating globally, concentrated among civilians and migrants in border areas, and poses grave harms to women and children. The current study investigates how women’s life-course experiences of conflict and displacement are linked to maternal stress and health outcomes after childbirth at the Thailand-Myanmar border, specifically stress, mental health, and cardiometabolic outcomes. Analyses are based on a cross-sectional population-based maternal and child health survey of 701 mothers, collected in 2017–18 in northern Thailand along the Myanmar border, including in camps, worksites, and residential homes. Results suggest that how conflict violence shapes contemporary stress and health depends on the outcome, level and timing of conflict violence exposure, and subsequent contextual threats and deprivation in displacement contexts. Past conflict violence was associated with symptoms of perceived stress (PS) and generalized anxiety disorder (GAD) but not depression. It was also associated with hypothalamic-pituitary-adrenal (HPA) axis activity (hair cortisol concentration) and adiposity (waist circumference and waist-to-hip ratio). Additionally, past conflict violence that began in childhood was particularly salient for PS, GAD, and adiposity; and level and timing of violence were salient jointly for HPA activity. Post-displacement factors also independently predicted higher blood pressure and played a potentially partial mediating role in the association between conflict exposure and both PS and GAD symptoms.
{"title":"Echoes of conflict and displacement in maternal health: Life-course violence, timing, and maternal stress after childbirth at the northern Thailand-Myanmar border","authors":"Stephanie M. Koning , Emma K. Adam , Amita Kapoor , Thomas W. McDade","doi":"10.1016/j.psyneuen.2024.107189","DOIUrl":"10.1016/j.psyneuen.2024.107189","url":null,"abstract":"<div><div>Armed conflict, displacement, and related violence is escalating globally, concentrated among civilians and migrants in border areas, and poses grave harms to women and children. The current study investigates how women’s life-course experiences of conflict and displacement are linked to maternal stress and health outcomes after childbirth at the Thailand-Myanmar border, specifically stress, mental health, and cardiometabolic outcomes. Analyses are based on a cross-sectional population-based maternal and child health survey of 701 mothers, collected in 2017–18 in northern Thailand along the Myanmar border, including in camps, worksites, and residential homes. Results suggest that how conflict violence shapes contemporary stress and health depends on the outcome, level and timing of conflict violence exposure, and subsequent contextual threats and deprivation in displacement contexts. Past conflict violence was associated with symptoms of perceived stress (PS) and generalized anxiety disorder (GAD) but not depression. It was also associated with hypothalamic-pituitary-adrenal (HPA) axis activity (hair cortisol concentration) and adiposity (waist circumference and waist-to-hip ratio). Additionally, past conflict violence that began in childhood was particularly salient for PS, GAD, and adiposity; and level and timing of violence were salient jointly for HPA activity. Post-displacement factors also independently predicted higher blood pressure and played a potentially partial mediating role in the association between conflict exposure and both PS and GAD symptoms.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107189"},"PeriodicalIF":3.4,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1016/j.psyneuen.2024.107192
Benedict Herhaus , Martin Heni , Wilhelm Bloch , Katja Petrowski
The neurotrophic protein brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain function and is affected by acute and chronic stress. We here investigate the patterns of BDNF and cortisol stress reactivity and recovery under the standardized stress protocol of the TSST and the effect of perceived chronic stress on the basal BDNF levels in healthy young men. Twenty-nine lean young men underwent the Trier Social Stress Test (TSST) and a resting condition. Serum BDNF and cortisol were measured before and repeatedly after both conditions. The perception of chronic stress was assessed by the Trier Inventory for Chronic Stress (TICS). After the TSST, there was a significant increase over time for BDNF and cortisol. Stronger increase in cortisol in response to stress was linked to an accelerated BDNF decline after stress. Basal resting levels of BDNF was significantly predicted by chronic stress perception. The increased BDNF level following psychosocial stress suggest a stress-induced neuroprotective mechanism. The presumed interplay between BDNF and the HPA-axis indicates an antagonistic relationship of cortisol on BDNF recovery post-stress. Chronically elevated high cortisol levels, as present in chronic stress, could thereby contribute to reduced neurogenesis, and an increased risk of neurodegenerative conditions in persons suffering from chronic stress.
{"title":"Dynamic interplay of cortisol and BDNF in males under acute and chronic psychosocial stress – A randomized controlled study","authors":"Benedict Herhaus , Martin Heni , Wilhelm Bloch , Katja Petrowski","doi":"10.1016/j.psyneuen.2024.107192","DOIUrl":"10.1016/j.psyneuen.2024.107192","url":null,"abstract":"<div><div>The neurotrophic protein brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain function and is affected by acute and chronic stress. We here investigate the patterns of BDNF and cortisol stress reactivity and recovery under the standardized stress protocol of the TSST and the effect of perceived chronic stress on the basal BDNF levels in healthy young men. Twenty-nine lean young men underwent the Trier Social Stress Test (TSST) and a resting condition. Serum BDNF and cortisol were measured before and repeatedly after both conditions. The perception of chronic stress was assessed by the Trier Inventory for Chronic Stress (TICS). After the TSST, there was a significant increase over time for BDNF and cortisol. Stronger increase in cortisol in response to stress was linked to an accelerated BDNF decline after stress. Basal resting levels of BDNF was significantly predicted by chronic stress perception. The increased BDNF level following psychosocial stress suggest a stress-induced neuroprotective mechanism. The presumed interplay between BDNF and the HPA-axis indicates an antagonistic relationship of cortisol on BDNF recovery post-stress. Chronically elevated high cortisol levels, as present in chronic stress, could thereby contribute to reduced neurogenesis, and an increased risk of neurodegenerative conditions in persons suffering from chronic stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"170 ","pages":"Article 107192"},"PeriodicalIF":3.4,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1016/j.psyneuen.2024.107185
Thais Martins-Silva , Rafaela Costa Martins , Joseph Murray , Andressa Marques Carvalho , Letícia Neutzling Rickes , Beatriz de Freitas Corrêa , Brenda Barbon Fraga , Clarice Brinck Brum , Deise Farias Freitas , Fernando Diógenes Teixeira Meyer , Marina Xavier Carpena , Laura Moreira Goularte , Andrea Gonzalez , Isabel Oliveira de Oliveira , Luciana Tovo-Rodrigues
Summarising hair cortisol concentration (HCC) methodology may provide much-needed data toward protocol standardisation to maximise future comparability of findings across studies. We searched five electronic databases, reviewing 11,716 publications focused on protocols previously used to measure hair cortisol. Our aim was to determine the frequency with which each procedure was reported in the literature. We then conducted a meta-analysis of the HCC results and proposed a checklist for reporting methodological procedures related to HCC. Using pre-selected key terms, we searched for population-based, non-experimental studies reporting HCC outcomes published up to November 2023. Eighty-seven analytical samples were included in the qualitative analysis and 28 in the quantitative analysis. The analyzed studies predominantly included children (≤10 years; 45.4 %) and mainly involved participants from European populations (72.6 %). There was significant variation in hair sample collection procedures across the studies. Most used hair samples up to 3 cm in length (92 %), with around one-third employing either milled (33.3 %) or minced (29.9 %) as grinding methods. For quantification, LC-MS was the most common method (47.1 %), followed by ELISA (24.1 %). Meta-analysis showed significant variability in the mean HCC observed. Meta-regression showed no association between differences in methodology and HCC. In conclusion, the absence of a standardized protocol in HCC research may result in procedural variability, making it difficult to compare findings across studies. Many published studies lacked sufficient detail in describing their methods. To address this, we propose a checklist of reporting guidelines for measurement procedures related to HCC.
{"title":"Hair cortisol measurement: A systematic review of current practices and a proposed checklist for reporting standards","authors":"Thais Martins-Silva , Rafaela Costa Martins , Joseph Murray , Andressa Marques Carvalho , Letícia Neutzling Rickes , Beatriz de Freitas Corrêa , Brenda Barbon Fraga , Clarice Brinck Brum , Deise Farias Freitas , Fernando Diógenes Teixeira Meyer , Marina Xavier Carpena , Laura Moreira Goularte , Andrea Gonzalez , Isabel Oliveira de Oliveira , Luciana Tovo-Rodrigues","doi":"10.1016/j.psyneuen.2024.107185","DOIUrl":"10.1016/j.psyneuen.2024.107185","url":null,"abstract":"<div><div>Summarising hair cortisol concentration (HCC) methodology may provide much-needed data toward protocol standardisation to maximise future comparability of findings across studies. We searched five electronic databases, reviewing 11,716 publications focused on protocols previously used to measure hair cortisol. Our aim was to determine the frequency with which each procedure was reported in the literature. We then conducted a meta-analysis of the HCC results and proposed a checklist for reporting methodological procedures related to HCC. Using pre-selected key terms, we searched for population-based, non-experimental studies reporting HCC outcomes published up to November 2023. Eighty-seven analytical samples were included in the qualitative analysis and 28 in the quantitative analysis. The analyzed studies predominantly included children (≤10 years; 45.4 %) and mainly involved participants from European populations (72.6 %). There was significant variation in hair sample collection procedures across the studies. Most used hair samples up to 3 cm in length (92 %), with around one-third employing either milled (33.3 %) or minced (29.9 %) as grinding methods. For quantification, LC-MS was the most common method (47.1 %), followed by ELISA (24.1 %). Meta-analysis showed significant variability in the mean HCC observed. Meta-regression showed no association between differences in methodology and HCC. In conclusion, the absence of a standardized protocol in HCC research may result in procedural variability, making it difficult to compare findings across studies. Many published studies lacked sufficient detail in describing their methods. To address this, we propose a checklist of reporting guidelines for measurement procedures related to HCC.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107185"},"PeriodicalIF":3.4,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-20DOI: 10.1016/j.psyneuen.2024.107193
Thomas O’Toole , Christopher J. Armitage , Martie van Tongeren , Kimberly A. Dienes
Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association may be influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic load cross-sectionally and at a lag of four years, stratified by level of effort-reward imbalance.
The sample consisted of respondents from the English Longitudinal Study of Ageing (ELSA) who were in employment with hair cortisol measurements at baseline (wave 6), and allostatic load markers at baseline and follow-up (wave 8; n=411; 64 % female). Hair cortisol was used as a measure of total cortisol expression over the preceding two months. Allostatic load was modelled as a count-based index using nine markers; three per system, across the immune, metabolic and cardiovascular systems. This model was then grouped by a median-cut effort reward-imbalance scale (0.83) and regression pathways were compared between groups using a series of Chi-Squared tests of difference.
Results provide evidence that higher hair cortisol concentrations predict an increase in immune and cardiovascular allostatic load cross-sectionally, and a metabolic allostatic load at a lag of four years. These pathways were found in the high effort-reward imbalance group, but not in the low effort-reward imbalance group. There were also significant differences found between groups for hair cortisol concentration as a predictor of concurrent immune and cardiovascular allostatic load
Findings may indicate a novel temporality to the accumulation of an allostatic load, and that the “tipping point” between allostasis and allostatic load may lie within the ability of the HPA axis to regulate the cardiovascular system concurrently, with longitudinal consequences for metabolic syndrome indicators.
{"title":"Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing","authors":"Thomas O’Toole , Christopher J. Armitage , Martie van Tongeren , Kimberly A. Dienes","doi":"10.1016/j.psyneuen.2024.107193","DOIUrl":"10.1016/j.psyneuen.2024.107193","url":null,"abstract":"<div><div>Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association may be influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic load cross-sectionally and at a lag of four years, stratified by level of effort-reward imbalance.</div><div>The sample consisted of respondents from the English Longitudinal Study of Ageing (ELSA) who were in employment with hair cortisol measurements at baseline (wave 6), and allostatic load markers at baseline and follow-up (wave 8; n=411; 64 % female). Hair cortisol was used as a measure of total cortisol expression over the preceding two months. Allostatic load was modelled as a count-based index using nine markers; three per system, across the immune, metabolic and cardiovascular systems. This model was then grouped by a median-cut effort reward-imbalance scale (0.83) and regression pathways were compared between groups using a series of Chi-Squared tests of difference.</div><div>Results provide evidence that higher hair cortisol concentrations predict an increase in immune and cardiovascular allostatic load cross-sectionally, and a metabolic allostatic load at a lag of four years. These pathways were found in the high effort-reward imbalance group, but not in the low effort-reward imbalance group. There were also significant differences found between groups for hair cortisol concentration as a predictor of concurrent immune and cardiovascular allostatic load</div><div>Findings may indicate a novel temporality to the accumulation of an allostatic load, and that the “tipping point” between allostasis and allostatic load may lie within the ability of the HPA axis to regulate the cardiovascular system concurrently, with longitudinal consequences for metabolic syndrome indicators.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107193"},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1016/j.psyneuen.2024.107190
Merel van Andel , Natasja M. van Schoor , Nicole C. Korten , Annemieke C. Heijboer , Madeleine L. Drent
Background
Leptin and ghrelin have been linked to depressive symptoms in older adults. There is a large overlap between depression and anxiety in this group. It is unclear whether the same associations exist with anxiety. Adiponectin has an inverse association with anxiety in older adults. However, the association between the most biologically active isoform - high-molecular-weight (HMW) adiponectin - and anxiety has not been previously reported.
Methods
We analyzed the association between leptin, ghrelin and HMW adiponectin and general symptoms of anxiety (HADS-A score ≥ 7) at baseline and after three years of follow-up in a population based cohort of older adults in the Netherlands (n = 898) using multivariable logistic regression analyses.
Results
For leptin there was significant effect modification by sex. We found a positive association between leptin and general symptoms of anxiety in men at baseline and after three years of follow-up after adjusting for depressive symptoms, when comparing the third to the first leptin tertile (T3 vs T1 OR 3.40, 95 % CI 1.08 – 10.78).
We found no significant associations for ghrelin.
HMW adiponectin was associated with general symptoms of anxiety at follow up. We found a positive association both before and after adjustment for depressive symptoms (T3 vs T1 OR 3.26, 95 % CI 1.36 – 7.83).
Conclusions
Our results showed significant associations in men only between leptin and HMW adiponectin and general symptoms of anxiety after three years of follow up. Our findings contribute to further insight into the pathophysiology of anxiety in older adults. However, further research is necessary as we show associations.
背景瘦素和胃泌素与老年人的抑郁症状有关。在这一群体中，抑郁症和焦虑症有很大的重叠。目前还不清楚焦虑是否也与抑郁有同样的联系。在老年人中，脂肪连接蛋白与焦虑呈反向关系。方法我们使用多变量逻辑回归分析方法，分析了荷兰老年人群（n = 898）中瘦素、胃泌素和高分子量脂肪连通素在基线时和随访三年后与一般焦虑症状（HADS-A 评分≥ 7 分）之间的关系。在将瘦素三等分与瘦素一等分（T3 vs T1 OR 3.40, 95 % CI 1.08 - 10.78）进行比较后，我们发现在基线和三年随访后，瘦素与男性的一般焦虑症状呈正相关（T3 vs T1 OR 3.40, 95 % CI 1.08 - 10.78）。我们发现，在对抑郁症状进行调整之前和调整之后（T3 vs T1 OR 3.26，95 % CI 1.36 - 7.83），两者之间均存在正相关。我们的研究结果有助于进一步了解老年人焦虑的病理生理学。不过，由于我们的研究显示了相关性，因此有必要开展进一步的研究。
{"title":"Leptin, ghrelin and high-molecular-weight adiponectin in relation to anxiety in older adults","authors":"Merel van Andel , Natasja M. van Schoor , Nicole C. Korten , Annemieke C. Heijboer , Madeleine L. Drent","doi":"10.1016/j.psyneuen.2024.107190","DOIUrl":"10.1016/j.psyneuen.2024.107190","url":null,"abstract":"<div><h3>Background</h3><p>Leptin and ghrelin have been linked to depressive symptoms in older adults. There is a large overlap between depression and anxiety in this group. It is unclear whether the same associations exist with anxiety. Adiponectin has an inverse association with anxiety in older adults. However, the association between the most biologically active isoform - high-molecular-weight (HMW) adiponectin - and anxiety has not been previously reported.</p></div><div><h3>Methods</h3><p>We analyzed the association between leptin, ghrelin and HMW adiponectin and general symptoms of anxiety (HADS-A score ≥ 7) at baseline and after three years of follow-up in a population based cohort of older adults in the Netherlands (n = 898) using multivariable logistic regression analyses.</p></div><div><h3>Results</h3><p>For leptin there was significant effect modification by sex. We found a positive association between leptin and general symptoms of anxiety in men at baseline and after three years of follow-up after adjusting for depressive symptoms, when comparing the third to the first leptin tertile (T3 vs T1 OR 3.40, 95 % CI 1.08 – 10.78).</p><p>We found no significant associations for ghrelin.</p><p>HMW adiponectin was associated with general symptoms of anxiety at follow up. We found a positive association both before and after adjustment for depressive symptoms (T3 vs T1 OR 3.26, 95 % CI 1.36 – 7.83).</p></div><div><h3>Conclusions</h3><p>Our results showed significant associations in men only between leptin and HMW adiponectin and general symptoms of anxiety after three years of follow up. Our findings contribute to further insight into the pathophysiology of anxiety in older adults. However, further research is necessary as we show associations.</p></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"170 ","pages":"Article 107190"},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S030645302400235X/pdfft?md5=ac342c14816a6e2a64b9aaaa98dde914&pid=1-s2.0-S030645302400235X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1016/j.psyneuen.2024.107186
Grant S. Shields, Colton L. Hunter, Zach Buckner , Mikayla D.M. Tolliver, Anastasia Makhanova
Although coming down with an illness or receiving a vaccine are both common experiences, the influence of such acute immune system activations on cognitive processes, such as inhibitory control, has received relatively little attention. We addressed that issue by assessing the effects of acute immune system activation on inhibitory control in a randomized controlled experiment, and by conducting a meta-analysis of similar studies in humans. In our experiment, we found—somewhat surprisingly—that influenza vaccination improved performance on both of our inhibitory control outcomes (i.e., stop-signal reaction times and flanker interference effects). At the meta-analytic level, we found that at a short delay (1.5–4 hours post-injection) between immune activation and inhibitory control assessment, such activation impaired multiple forms of inhibitory control, whereas after a longer delay (e.g., > 18 hours post-injection), such activation improved inhibitory control—consistent with our experiment. Moreover, proinflammatory cytokine activity predicted poorer interference control but better response inhibition, even with a long delay between injection and testing. Together, these results highlight nuanced, time-dependent, and—perhaps—multiple-mechanism-driven effects of acute immune system activity on inhibitory control.
{"title":"Acute immune system activation exerts time-dependent effects on inhibitory control: Results of both a randomized controlled experiment of influenza vaccination and a systematic review and meta-analysis – ISPNE 2024 Dirk Hellhammer Award","authors":"Grant S. Shields, Colton L. Hunter, Zach Buckner , Mikayla D.M. Tolliver, Anastasia Makhanova","doi":"10.1016/j.psyneuen.2024.107186","DOIUrl":"10.1016/j.psyneuen.2024.107186","url":null,"abstract":"<div><div>Although coming down with an illness or receiving a vaccine are both common experiences, the influence of such acute immune system activations on cognitive processes, such as inhibitory control, has received relatively little attention. We addressed that issue by assessing the effects of acute immune system activation on inhibitory control in a randomized controlled experiment, and by conducting a meta-analysis of similar studies in humans. In our experiment, we found—somewhat surprisingly—that influenza vaccination improved performance on both of our inhibitory control outcomes (i.e., stop-signal reaction times and flanker interference effects). At the meta-analytic level, we found that at a short delay (1.5–4 hours post-injection) between immune activation and inhibitory control assessment, such activation impaired multiple forms of inhibitory control, whereas after a longer delay (e.g., > 18 hours post-injection), such activation improved inhibitory control—consistent with our experiment. Moreover, proinflammatory cytokine activity predicted poorer interference control but better response inhibition, even with a long delay between injection and testing. Together, these results highlight nuanced, time-dependent, and—perhaps—multiple-mechanism-driven effects of acute immune system activity on inhibitory control.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107186"},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1016/j.psyneuen.2024.107188
Ruby S.M. Tsang , Nicholas J. Timpson , Golam M. Khandaker
Psychotic disorder is associated with altered levels of various inflammatory markers in blood, but existing studies have typically focused on a few selected biomarkers, have not examined specific symptom domains notably negative symptoms, and are based on individuals with established/chronic illness. Based on data from young people aged 24 years from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK birth cohort, we have examined the associations of 67 plasma immune/inflammatory proteins assayed using the Olink Target 96 Inflammation panel with psychotic disorder, positive (any psychotic experiences and definite psychotic experiences) and negative symptoms, using linear models with empirical Bayes estimation. The analyses included between 2317 and 2854 individuals. After adjustment for age, sex, body mass index and smoking and correction for multiple testing, positive symptoms and psychotic disorder were consistently associated with upregulation of CDCP1 and IL-6, and psychotic disorder was additionally associated with upregulation of MMP-10. Negative symptoms were associated with upregulation of CDCP1 and TRAIL. CDCP1 and MMP-10 are novel markers of psychosis identified in this study, and are involved in immune regulation, immune cell activation/migration, blood-brain barrier disruption, and extracellular matrix abnormalities. Our findings highlight psychosis symptom domains have overlapping and distinct immune associations, and support a role of inflammation and immune dysfunction in the pathogenesis of psychosis.
{"title":"Inflammation proteomic profiling of psychosis in young adults: Findings from the ALSPAC birth cohort","authors":"Ruby S.M. Tsang , Nicholas J. Timpson , Golam M. Khandaker","doi":"10.1016/j.psyneuen.2024.107188","DOIUrl":"10.1016/j.psyneuen.2024.107188","url":null,"abstract":"<div><div>Psychotic disorder is associated with altered levels of various inflammatory markers in blood, but existing studies have typically focused on a few selected biomarkers, have not examined specific symptom domains notably negative symptoms, and are based on individuals with established/chronic illness. Based on data from young people aged 24 years from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK birth cohort, we have examined the associations of 67 plasma immune/inflammatory proteins assayed using the Olink Target 96 Inflammation panel with psychotic disorder, positive (any psychotic experiences and definite psychotic experiences) and negative symptoms, using linear models with empirical Bayes estimation. The analyses included between 2317 and 2854 individuals. After adjustment for age, sex, body mass index and smoking and correction for multiple testing, positive symptoms and psychotic disorder were consistently associated with upregulation of CDCP1 and IL-6, and psychotic disorder was additionally associated with upregulation of MMP-10. Negative symptoms were associated with upregulation of CDCP1 and TRAIL. CDCP1 and MMP-10 are novel markers of psychosis identified in this study, and are involved in immune regulation, immune cell activation/migration, blood-brain barrier disruption, and extracellular matrix abnormalities. Our findings highlight psychosis symptom domains have overlapping and distinct immune associations, and support a role of inflammation and immune dysfunction in the pathogenesis of psychosis.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107188"},"PeriodicalIF":3.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1016/j.psyneuen.2024.107184
Avery M. Anderson , Jessica Sherman , Margaret M. Fitzpatrick , Christopher Browning , Darlene A. Kertes , Amy Mackos , Rita H. Pickler , Lindsay Smith , Jodi L. Ford
Introduction
Adolescents experience high levels of loneliness, which is linked to poor health in adulthood. Loneliness may contribute to poor health through chronic dysregulation of the hypothalamic-pituitary-adrenal axis. In this analysis, we examined the associations between survey- and ecological momentary assessment (EMA)-based measures of loneliness and hair cortisol concentrations (HCC) in a sample of 1102 adolescents and assessed sex differences in this relationship.
Methods
Data came from wave 1 of the Adolescent Health and Development in Context study. We conducted a series of multivariable linear regression models to examine the associations between loneliness and HCC. Models were adjusted for adolescent and caregiver demographics, adolescent clinical factors, adolescent hair care practices, and adolescent lifetime mental health diagnosis and current psychotropic medication use. An interaction term between sex and loneliness was added to assess for effect moderation.
Results
In our sample, the mean HCC was 1.35 pg/mg (SD=1.1). The mean for the unstandardized survey loneliness measure was 1.79 (SD=0.79) for the total analytic sample. The unstandardized mean for the EMA loneliness measure was - 0.02 (SD=2.1) for the total analytic sample. In model one testing the bivariate linear relationship between loneliness and HCC, higher loneliness via survey and EMA measures was associated with lower HCC (Survey: b= - 0.10, SE=0.03, p=.004; EMA: b= - 0.09, SE=0.03, p=.005). In model two, higher loneliness remained significantly associated with lower HCC (Survey: b= - 0.07, SE=0.03, p=.023; EMA: b= - 0.07, SE=0.03, p=.037), after controlling for the following covariates: sociodemographic factors, pubertal development and BMI, corticosteroid use, hair care practices, season of collection and assayed hair length. In model 3, youth lifetime mental health diagnosis and current psychotropic medication use were added into the regression model, and higher loneliness remained significantly associated with lower HCC (Survey: b= - 0.07, SE=0.03, p=.029; EMA: b= - 0.07, SE=0.03, p=.039). There was no effect modification by sex (Survey: b=0.04, SE=0.06, p=.552; EMA: b= - 0.01, SE=0.06, p=.843).
Conclusions
In our analysis, both survey- and EMA-reported loneliness measures were associated with lower HCC. No evidence of an interaction between sex and loneliness was observed. Future research is needed to validate these findings and investigate longitudinal relationships among adolescent loneliness, stress physiology, and downstream health sequelae.
{"title":"Associations between adolescent perceived loneliness and hair cortisol concentration","authors":"Avery M. Anderson , Jessica Sherman , Margaret M. Fitzpatrick , Christopher Browning , Darlene A. Kertes , Amy Mackos , Rita H. Pickler , Lindsay Smith , Jodi L. Ford","doi":"10.1016/j.psyneuen.2024.107184","DOIUrl":"10.1016/j.psyneuen.2024.107184","url":null,"abstract":"<div><h3>Introduction</h3><div>Adolescents experience high levels of loneliness, which is linked to poor health in adulthood. Loneliness may contribute to poor health through chronic dysregulation of the hypothalamic-pituitary-adrenal axis. In this analysis, we examined the associations between survey- and ecological momentary assessment (EMA)-based measures of loneliness and hair cortisol concentrations (HCC) in a sample of 1102 adolescents and assessed sex differences in this relationship.</div></div><div><h3>Methods</h3><div>Data came from wave 1 of the Adolescent Health and Development in Context study. We conducted a series of multivariable linear regression models to examine the associations between loneliness and HCC. Models were adjusted for adolescent and caregiver demographics, adolescent clinical factors, adolescent hair care practices, and adolescent lifetime mental health diagnosis and current psychotropic medication use. An interaction term between sex and loneliness was added to assess for effect moderation.</div></div><div><h3>Results</h3><div>In our sample, the mean HCC was 1.35 pg/mg (SD=1.1). The mean for the <em>unstandardized</em> survey loneliness measure was 1.79 (<em>SD</em>=0.79) for the total analytic sample. The <em>unstandardized</em> mean for the EMA loneliness measure was - 0.02 (<em>SD</em>=2.1) for the total analytic sample. In model one testing the bivariate linear relationship between loneliness and HCC, higher loneliness via survey and EMA measures was associated with lower HCC (<em>Survey</em>: <em>b</em>= - 0.10, SE=0.03, <em>p</em>=.004; <em>EMA</em>: <em>b</em>= - 0.09, SE=0.03, <em>p</em>=.005). In model two, higher loneliness remained significantly associated with lower HCC (<em>Survey</em>: <em>b</em>= - 0.07, SE=0.03, <em>p</em>=.023; <em>EMA</em>: <em>b</em>= - 0.07, SE=0.03, <em>p</em>=.037), after controlling for the following covariates: sociodemographic factors, pubertal development and BMI, corticosteroid use, hair care practices, season of collection and assayed hair length. In model 3, youth lifetime mental health diagnosis and current psychotropic medication use were added into the regression model, and higher loneliness remained significantly associated with lower HCC (<em>Survey</em>: <em>b</em>= - 0.07, SE=0.03, <em>p</em>=.029; <em>EMA</em>: <em>b</em>= - 0.07, SE=0.03, <em>p</em>=.039). There was no effect modification by sex (<em>Survey</em>: <em>b</em>=0.04, SE=0.06, <em>p</em>=.552; <em>EMA</em>: <em>b</em>= - 0.01, SE=0.06, <em>p</em>=.843).</div></div><div><h3>Conclusions</h3><div>In our analysis, both survey- and EMA-reported loneliness measures were associated with lower HCC. No evidence of an interaction between sex and loneliness was observed. Future research is needed to validate these findings and investigate longitudinal relationships among adolescent loneliness, stress physiology, and downstream health sequelae.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"170 ","pages":"Article 107184"},"PeriodicalIF":3.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142324198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-14DOI: 10.1016/j.psyneuen.2024.107181
Stephanie M. Koning , Courtenay L. Kessler , Turhan Canli , Elif A. Duman , Emma K. Adam , Richard Zinbarg , Michelle G. Craske , Jacquelyn E. Stephens , Suzanne Vrshek-Schallhorn
Background
Epigenetic modifications, including DNA methylation (DNAm), can play a role in the biological embedding of early-life adversity (ELA) through serotonergic mechanisms. The current study examines methylation of the CpG island in the promoter region of the stress-responsive serotonin transporter gene (SLC6A4) and is the first to jointly assess how it is influenced by ELA severity, timing, and type—specifically, deprivation and threat.
Methods
We use data from 627 Youth Emotion Project study participants, recruited from two US high schools. Using adjusted linear regressions, we analyze DNA collected in early adulthood from 410 participants and ELA based on interviewer-rated responses from concurrent Childhood Trauma Interviews, adjusting for survey-measured covariates.
Results
ELA robustly predicted mean CpG island SLC6A4 DNAm percent across 71 CpG sites. Each additional major-severity ELA event was associated with a 0.121-percentage-point increase (p<0.001), equating to a 0.177 standard deviation (sd) higher DNAm level (95 % CI: 0.080, 0.274) with each 1-sd higher adversity score. When modeled separately, both childhood and adolescent ELA predicted SLC6A4 DNAm. When modeled jointly, adolescent ELA was most strongly predictive, and child adversity remained significantly associated with DNAm through indirect associations via adolescent adversity. Additionally, the ELA-SLC6A4 DNAm association may vary by adversity type. Across separate models for childhood and adolescent exposures, deprivation coefficients are positive and statistically significant. Meanwhile, threat coefficients are positive and not significantly significant but do not statistically differ from deprivation coefficients. In models including all ELA dimensions, one major adolescent deprivation event is associated with a 0.222-percentage-point increased SLC6A4 DNAm (p<0.05), or a 1-sd higher deprivation score with a 0.157-sd increased DNAm.
Conclusion
Results further implicate epigenetic modification on serotonergic neurotransmission via DNAm in the downstream sequelae of ELA—particularly adolescent deprivation—and support preventive interventions in adolescence to mitigate biological embedding.
背景包括DNA甲基化（DNAm）在内的表观遗传修饰可通过血清素能机制在早期生活逆境（ELA）的生物嵌入中发挥作用。本研究考察了应激反应型血清素转运体基因（SLC6A4）启动子区域CpG岛的甲基化情况，并首次联合评估了ELA的严重程度、时间和类型（特别是剥夺和威胁）对甲基化的影响。通过调整线性回归，我们分析了从 410 名参与者成年早期收集的 DNA 以及基于同时进行的童年创伤访谈中访谈者评分的 ELA，并对调查测量的协变量进行了调整。每增加一个严重的ELA事件，DNAm水平就会增加0.121个百分点（p<0.001），相当于逆境得分每增加1个百分点，DNAm水平就会增加0.177个标准差（sd）（95 % CI：0.080, 0.274）。如果单独建模，童年和青少年 ELA 都能预测 SLC6A4 DNAm。当联合建模时，青少年 ELA 的预测作用最强，而儿童逆境仍通过青少年逆境的间接关联与 DNAm 显著相关。此外，ELA-SLC6A4 DNAm 的关联可能因逆境类型而异。在儿童和青少年暴露的不同模型中，匮乏系数为正且具有统计意义。同时，威胁系数为正且不显著，但在统计上与匮乏系数没有差异。在包括所有 ELA 维度的模型中，一次重大的青少年剥夺事件与 SLC6A4 DNAm 上升 0.222 个百分点相关（p<0.05），或者剥夺得分高 1 个百分点，DNAm 上升 0.157 个百分点。
{"title":"Early-life adversity severity, timing, and context type are associated with SLC6A4 methylation in emerging adults: Results from a prospective cohort study","authors":"Stephanie M. Koning , Courtenay L. Kessler , Turhan Canli , Elif A. Duman , Emma K. Adam , Richard Zinbarg , Michelle G. Craske , Jacquelyn E. Stephens , Suzanne Vrshek-Schallhorn","doi":"10.1016/j.psyneuen.2024.107181","DOIUrl":"10.1016/j.psyneuen.2024.107181","url":null,"abstract":"<div><h3>Background</h3><p>Epigenetic modifications, including DNA methylation (DNAm), can play a role in the biological embedding of early-life adversity (ELA) through serotonergic mechanisms. The current study examines methylation of the CpG island in the promoter region of the stress-responsive serotonin transporter gene (<em>SLC6A4</em>) and is the first to jointly assess how it is influenced by ELA severity, timing, and type—specifically, deprivation and threat.</p></div><div><h3>Methods</h3><p>We use data from 627 Youth Emotion Project study participants, recruited from two US high schools. Using adjusted linear regressions, we analyze DNA collected in early adulthood from 410 participants and ELA based on interviewer-rated responses from concurrent Childhood Trauma Interviews, adjusting for survey-measured covariates.</p></div><div><h3>Results</h3><p>ELA robustly predicted mean CpG island <em>SLC6A4</em> DNAm percent across 71 CpG sites. Each additional major-severity ELA event was associated with a 0.121-percentage-point increase (<em>p</em><0.001), equating to a 0.177 standard deviation (sd) higher DNAm level (95 % CI: 0.080, 0.274) with each 1-sd higher adversity score. When modeled separately, both childhood and adolescent ELA predicted <em>SLC6A4</em> DNAm. When modeled jointly, adolescent ELA was most strongly predictive, and child adversity remained significantly associated with DNAm through indirect associations via adolescent adversity. Additionally, the ELA-<em>SLC6A4</em> DNAm association may vary by adversity type. Across separate models for childhood and adolescent exposures, deprivation coefficients are positive and statistically significant. Meanwhile, threat coefficients are positive and not significantly significant but do not statistically differ from deprivation coefficients. In models including all ELA dimensions, one major adolescent deprivation event is associated with a 0.222-percentage-point increased <em>SLC6A4</em> DNAm (<em>p</em><0.05), or a 1-sd higher deprivation score with a 0.157-sd increased DNAm.</p></div><div><h3>Conclusion</h3><p>Results further implicate epigenetic modification on serotonergic neurotransmission via DNAm in the downstream sequelae of ELA—particularly adolescent deprivation—and support preventive interventions in adolescence to mitigate biological embedding.</p></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"170 ","pages":"Article 107181"},"PeriodicalIF":3.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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