Psychoneuroendocrinology最新文献_第9页

Glucocorticoid metabolism: A scientific lifetime in and beyond psychoneuroendocrinology 糖皮质激素代谢：精神神经内分泌学内外的科学生命。

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-07 DOI: 10.1016/j.psyneuen.2025.107681

Jonathan Seckl

引用次数: 0

How colorism gets “under the skin”: The role of ethnic-racial discrimination and diurnal cortisol in the physical health of African American and Latino young adults 肤色歧视是如何“深入人心”的：种族歧视和皮质醇在非裔美国人和拉丁裔年轻人身体健康中的作用

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-06 DOI: 10.1016/j.psyneuen.2025.107676

Antoinette M. Landor , Katharine H. Zeiders , Alaysia M. Brown , Kayla M. Osman , Evelyn D. Sarsar , Jasmine Godwin

Empirical research has identified ethnic-racial discrimination as a fundamental driver of health disparities and a key contributor to poorer physical health outcomes among African American and Latino populations. Colorism–bias that generally privileges lighter skin over darker skin–has also been linked to adverse health outcomes; however, little to no research has explored how the intersection of colorism and racism “gets under the skin” to influence physical health, particularly among young adults. Grounded in an intersectional framework, the present study recognizes that multiple systems of oppression—namely racism and colorism—do not operate independently but intersect to uniquely impact individuals based on their racialized and phenotypic identities. Using a sample of African American and Latino young adults, the current study examined whether skin tone may be indirectly associated with poorer physical health due to its association with ethnic-racial discrimination and diurnal cortisol patterns. Findings indicated that darker skin young adults experienced more ethnic-racial discrimination, which in turn, was associated with flatter diurnal cortisol slopes. Flatter diurnal slopes were also marginally related to poorer self-reported health over time. Taken together, these results underscore the importance of applying an intersectional lens to understanding health disparities, highlighting how the interwoven impacts of colorism and racism function as sociocultural stressors that become biologically embedded, ultimately influencing the physical health of racially and ethnically marginalized young adults.

实证研究已经确定，族裔和种族歧视是造成健康差异的一个根本因素，也是造成非裔美国人和拉丁裔人口身体健康状况较差的一个关键因素。肤色偏见——通常认为浅肤色比深肤色更受青睐——也与不利的健康结果有关；然而，很少有研究探索肤色歧视和种族主义的交集是如何“深入人心”影响身体健康的，尤其是在年轻人中。在交叉框架的基础上，本研究认识到多重压迫系统——即种族主义和肤色——并不是独立运作的，而是相互交叉，以独特的方式影响基于种族化和表型身份的个人。目前的研究使用了非裔美国人和拉丁裔年轻人的样本，研究肤色是否可能与较差的身体健康间接相关，因为肤色与种族歧视和昼夜皮质醇模式有关。研究结果表明，皮肤较黑的年轻人经历了更多的种族歧视，这反过来又与较平坦的皮质醇日斜率有关。随着时间的推移，较平坦的日斜率也与较差的自我报告健康状况略有相关。综上所述，这些结果强调了应用交叉视角来理解健康差异的重要性，强调了肤色主义和种族主义的交织影响如何作为社会文化压力因素发挥作用，这些压力因素在生物学上根深蒂固，最终影响种族和民族边缘化的年轻人的身体健康。

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引用次数: 0

First-generation college student status and minoritized race and ethnicity: Intersectional predictors of life stress exposure and lab-based cortisol reactivity 第一代大学生身份和少数民族种族：生活压力暴露和实验室皮质醇反应的交叉预测因子

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-06 DOI: 10.1016/j.psyneuen.2025.107677

Darha M. Ponder , Suzanne Vrshek-Schallhorn , Chelsea B. Crayton , Alexandra M. Cupito , Gabriela Livas , Michaeline Jensen , Anne Fletcher

Theory and evidence link first-generation college students and minoritized race/ethnicity with heightened life stress exposure and potentially alterations in biological stress reactivity as adversity gets “under the skin,” but more evidence and statistical tools are needed to understand how multiple minoritized identities influence health. In 171 emerging adults, we tested hypotheses that these intersecting identities increase life stress exposure, measured with the UCLA Life Stress Interview; we also probe properties of four statistical approaches to modeling intersectional identities’ influence. In a subset of n = 150, growth curve modeling tested the hypothesis that more minoritized identities intensify discrimination’s effect on blunted cortisol reactivity to an explicit negative evaluative variant (n = 77) versus a control variant (n = 73) of the Trier Social Stress Test. Results link both minoritized identities with elevated exposure to non-interpersonal chronic stress (t = 3.85, p < .001), and minoritized race/ethnicity with elevated interpersonal chronic stress (t = 2.743, p = .007). Of the statistical approaches examined, an identity cumulative risk score demonstrated high sensitivity, consistent with developmental research. Finally, cumulative minoritized identities moderated the relationship between self-reported discrimination and cortisol reactivity to negative evaluative lab-based stress (t = 2.12, p = 0.035), driven by a significant discrimination and cortisol blunting association in those with both minoritized identities. Taken together, we provide evidence to support modeling intersectional identities as a cumulative risk score with post-hoc tests, and evidence that first-generation student status and minoritized race/ethnicity cumulatively heighten stress exposure and intensify the effect of discrimination on a maladaptive marker of stress-responding.

理论和证据表明，第一代大学生和少数族裔/民族与生活压力暴露的增加以及逆境“深入皮肤”时生物应激反应的潜在改变有关，但需要更多的证据和统计工具来了解多个少数族裔身份如何影响健康。在171名初出期的成年人中，我们测试了这些交叉身份增加生活压力暴露的假设，通过加州大学洛杉矶分校的生活压力访谈进行测量；我们还探讨了四种统计方法的性质来建模交叉身份的影响。在n = 150的子集中，增长曲线模型验证了这样的假设：与Trier社会压力测试的控制变量（n = 73）相比，更少数化的身份强化了歧视对显式负面评估变量（n = 77）的皮质醇反应性减弱的影响。结果表明，少数族裔身份与非人际慢性应激暴露增加有关（t = 3.85,p <； ）。001)，少数族裔/民族的人际慢性压力升高（t = 2.743,p = .007）。在研究的统计方法中，身份累积风险评分显示出高敏感性，与发展研究一致。最后，累积的少数化身份调节了自我报告的歧视和皮质醇对负面评价实验室压力的反应性之间的关系（t = 2.12,p = 0.035），这是由具有两种少数化身份的人的显著歧视和皮质醇钝化关联驱动的。综上所述，我们提供的证据支持将交叉身份建模为事后测试的累积风险评分，并证明第一代学生身份和少数族裔/民族累积增加压力暴露，并加剧歧视对压力反应不良标记的影响。

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引用次数: 0

Hippocampal prolactin receptor long-form signaling contributes to prenatal stress-induced depression-like behavior 海马体催乳素受体长形信号有助于产前应激诱导的抑郁样行为。

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-06 DOI: 10.1016/j.psyneuen.2025.107683

Dan Yao , Jing Li , Yong Lu , A’lin Sun , Xinglong Pang , Qiqi Yi , Zhongliang Zhu , Dongli Song , Yushan Lu , Hui Li

Prenatal stress (PS) is a well-established risk factor for depression-like behaviors in adolescent offspring. The prolactin receptor long-form (PRLR-LF), which has been implicated in depression pathogenesis, activates the downstream Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) signaling cascade. Immunoprecipitation assays demonstrated that nuclear STAT5 physically interacts with the glucocorticoid receptor (GR), forming a transcriptional repressor complex that attenuates GR-dependent gene expression. Given the critical role of hippocampal GR in stress responses and depression, we hypothesized that the PRLR-LF-JAK2/STAT5-GR pathway in the hippocampus mediates depression-like behavior in prenatally stressed offspring. We established a prenatal restraint stress model and assessed depression-like behavior using sucrose preference and forced swim tests. To establish causality, we genetically modulated PRLR-LF expression through hippocampal microinjection of AAV-mediated overexpression or knockdown constructs in 21-day-old offspring. The results show that PS significantly upregulated hippocampal PRLR-LF expression and JAK2/STAT5 phosphorylation while downregulating GR expression and nuclear translocation--effects observed exclusively in female offspring. PRLR-LF knockdown in PS-exposed females attenuated depression-like behavior, normalizing JAK2/STAT5 activation and GR dysfunction. Conversely, PRLR-LF overexpression in control females induced depression-like behavior and replicated GR suppression in the hippocampus. These results demonstrate that the hippocampal PRLR-LF-JAK2/STAT5-GR pathway drives sex-specific vulnerability to PS-induced depression in adolescent offspring, offering a mechanistic target for therapeutic intervention.

产前压力（PS）是青少年后代抑郁样行为的一个公认的危险因素。长型催乳素受体（PRLR-LF）激活下游Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 （STAT5）信号级联，与抑郁症的发病机制有关。免疫沉淀实验表明，核STAT5与糖皮质激素受体（GR）物理相互作用，形成转录抑制复合物，减弱GR依赖的基因表达。鉴于海马GR在应激反应和抑郁中的关键作用，我们假设海马PRLR-LF-JAK2/STAT5-GR通路介导了产前应激后代的抑郁样行为。我们建立了一个产前约束应激模型，并使用蔗糖偏好和强迫游泳测试来评估抑郁样行为。为了确定因果关系，我们通过在21日龄后代的海马中微量注射aav介导的过表达或敲低构建物，从基因上调节PRLR-LF的表达。结果表明，PS显著上调海马PRLR-LF表达和JAK2/STAT5磷酸化，下调GR表达和核易位，这些作用仅在雌性后代中观察到。暴露于ps的女性PRLR-LF敲低可减轻抑郁样行为，使JAK2/STAT5激活和GR功能障碍正常化。相反，对照组雌性PRLR-LF过表达诱导了抑郁样行为，并在海马中复制了GR抑制。这些结果表明，海马PRLR-LF-JAK2/STAT5-GR通路驱动青春期后代对ps诱导的抑郁的性别特异性易感性，为治疗干预提供了机制靶点。

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引用次数: 0

Stress-induced gene regulation in pregnant women: A systematic review and quantitative evidence synthesis 孕妇应激诱导的基因调控：系统综述和定量证据合成。

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-05 DOI: 10.1016/j.psyneuen.2025.107675

Monika Wójtowicz‑Marzec , Agnieszka Maria Berendt , Danuta Zarzycka , Jacek Bogucki , Janusz Kocki

Background

Prenatal psychosocial stress is linked to adverse maternal-infant outcomes, plausibly via stress-responsive endocrine pathways and epigenetic regulation. We examined associations between prenatal stress and maternal DNA methylation (DNAm) at key psychoneuroendocrine loci.

Methods

We conducted a PROSPERO-registered (CRD420251058768), PRISMA-aligned systematic review with quantitative evidence synthesis (QES). Searches (2014–2025) identified observational studies and one randomized trial sampling blood and saliva/buccal. Effects were standardized as Hedges’ g and pooled with random-effects only for like-for-like subsets (k ≥ 2). Dependence was handled with multilevel models and robust variance estimation; risk of bias and certainty used ROBINS-I/RoB 2 and GRADE.

Results

Findings for NR3C1 exon 1 F were heterogeneous across tissue, timing, and stress domain; outcomes were non-commensurable, so no single pooled estimate was computed. For FKBP5, intron 7 (k = 2) showed lower DNAm with greater trauma/PTSD burden (SMD = −0.36, 95 % CI −0.67 to −0.05; I² ≈ 0 %). Single-study contrasts suggested higher DNAm at intron 2 and lower DNAm at intron 5 with depressive symptoms. For OXTR (DNAm/mRNA), only single-study results were comparable; signals varied by phenotype/genotype. Absolute DNAm differences were typically < 1–3 %. Overall certainty was low to very low.

Conclusions

Prenatal stress is associated with detectable yet context-dependent epigenetic variation in peripheral tissues. No single CpG or region is ready for clinical use. Progress requires region- and tissue-matched replication, harmonized stress phenotyping with cell-type adjustment, and meta-analysis-friendly, open reporting.

背景：产前社会心理压力与不良母婴结局有关，可能通过应激反应性内分泌途径和表观遗传调控。我们研究了产前压力和母体DNA甲基化（DNAm）在关键精神神经内分泌位点之间的关系。方法：我们进行了一项普洛斯罗注册（CRD420251058768），与prisma对齐的定量证据合成（QES）系统评价。检索（2014-2025）确定了观察性研究和一项随机试验，取样血液和唾液/口腔。将效应标准化为对冲效应g，并仅对同类子集（k ≥ 2）与随机效应合并。采用多水平模型和稳健方差估计处理相关性；偏倚风险和确定性采用ROBINS-I/ rob2和GRADE。结果：NR3C1外显子1 F的发现在组织、时间和应激域具有异质性；结果是不可通约的，因此没有计算单一的汇总估计。对于FKBP5，内含子7 （k = 2）显示，DNAm越低，创伤/PTSD负担越大（SMD = -0.36, 95 % CI -0.67 ~ -0.05; I²≈0 %）。单项研究对比表明，内含子2较高的DNAm和内含子5较低的DNAm与抑郁症状有关。对于OXTR (DNAm/mRNA)，只有单一研究结果具有可比性；信号因表型/基因型而异。结论：产前应激与外周组织中可检测的但依赖于环境的表观遗传变异有关。没有单一的CpG或区域可以用于临床。进展需要区域和组织匹配的复制，协调应激表型与细胞类型调整，以及荟萃分析友好，开放的报告。

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引用次数: 0

Allostatic load and biological aging among middle aged adults 中年人的适应负荷与生物老化。

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-05 DOI: 10.1016/j.psyneuen.2025.107661

Henok M. Teferi , Rachel C. Shelton , Karen N. Conneely , Immaculata De Vivo , Pam Factor-Litvak , Katrina L. Kezios , Piera M. Cirillo , Barbara A. Cohn , Bruce G. Link , Shakira F. Suglia

引用次数: 0

Adverse childhood experiences patterns and biological aging in a representative sample of older Americans 不良童年经历模式和美国老年人代表性样本的生物老化。

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-05 DOI: 10.1016/j.psyneuen.2025.107682

Xiaoyan Zhang , Natalie Slopen , Ariel A. Binns , Adolfo G. Cuevas

Background

Adverse childhood experiences (ACEs) are common, co-occurring risk factors for poor long-term health. Emerging research links ACEs to accelerated biological aging, yet most studies rely on singular or cumulative indicators and often overlook differences by race, sex, and adversity type, potentially yielding imprecise estimates.

Objectives

To identify latent ACEs classes by race and sex using latent class analysis (LCA) and examine their associations with biological aging measured by DNA methylation-based epigenetic clocks.

Methods

We analyzed 3586 participants from the Health and Retirement Study, a nationally representative cohort of U.S. older adults. LCA identified ACEs classes based on nine indicators, including physical abuse, household substance use, and socioeconomic adversity. Biological aging was measured using GrimAge, PhenoAge, and DunedinPoAm clocks. Epigenetic age acceleration (EAA) was calculated as residuals of GrimAge/PhenoAge regressed on chronological age.

Results

Latent Low Adversity and Financial Adversity classes were identified among Black and White participants, and among Hispanic participants we identified Parental Low Education and Socioeconomic Adversity classes. Men exhibited higher GrimAge EAA than women across all groups. Among Black and White women, Financial Adversity was associated with elevated GrimAge EAA and a faster DunedinPoAm pace compared to the Low Adversity group. Among Hispanic women, Socioeconomic Adversity was linked to higher PhenoAge EAA and faster DunedinPoAm pace relative to those in the Parental Low Education group.

Conclusion

Women in the adversity classes demonstrated more accelerated biological aging than those in low adversity classes. Findings underscore the value of intersectional, person-centered approaches to understanding adversity’s role in biological aging and the need for targeted health interventions.

背景：不良童年经历（ace）是常见的，共同发生的不良长期健康的危险因素。新兴研究将ace与加速的生物衰老联系起来，但大多数研究依赖于单一或累积的指标，往往忽略了种族、性别和逆境类型的差异，可能会产生不精确的估计。目的：利用潜在类分析（LCA）按种族和性别识别潜在ace类，并通过基于DNA甲基化的表观遗传时钟检测其与生物衰老的关系。方法：我们分析了来自健康与退休研究的3586名参与者，这是一个具有全国代表性的美国老年人队列。LCA根据九项指标确定了ace类别，包括身体虐待、家庭物质使用和社会经济逆境。使用GrimAge、PhenoAge和DunedinPoAm时钟测量生物衰老。表观遗传年龄加速（EAA）计算为GrimAge/PhenoAge随实足年龄回归的残差。结果：在黑人和白人参与者中发现了潜在的低逆境和财务逆境，在西班牙裔参与者中，我们发现了父母低教育和社会经济逆境。在所有组中，男性的GrimAge EAA都高于女性。在黑人和白人女性中，与低逆境组相比，财务逆境组的GrimAge EAA升高，DunedinPoAm速度加快。在西班牙裔女性中，与父母受教育程度低的群体相比，社会经济逆境与更高的表型EAA和更快的DunedinPoAm速度有关。结论：逆境组的女性比低逆境组的女性表现出更快的生物衰老。研究结果强调了交叉的价值，以人为本的方法来理解逆境在生物衰老中的作用和有针对性的健康干预的必要性。

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引用次数: 0

Early life adversity and physical health implications in adulthood: The Multi-Ethnic Study of Atherosclerosis 早期生活逆境和成年后身体健康的影响：动脉粥样硬化的多民族研究。

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-04 DOI: 10.1016/j.psyneuen.2025.107674

Sharon Stein Merkin , Margaret A. Sheridan , Daniela Markovic , Bonnie C. Sachs , Teresa E. Seeman

Introduction

Several biological processes have been implicated in explaining the association between exposure to early life adversity (ELA) and poor health outcomes later in life, but most studies have classified ELA in terms of a simple count of adverse childhood events (ACEs). Few studies have also considered how race/ethnicity might modify these associations.

Objectives

To determine to what extent different dimensions of ELA (threat and deprivation) influence cardiometabolic and inflammatory dysregulation in adulthood by race/ethnic groups.

Methods

Participants in MESA, ages 45–84, were recruited from 2000 to 2002. Information regarding ELA was collected at the 2020 follow up call. Measures of inflammation (C-Reactive Protein, CRP) and cardiometabolic dysfunction (index of risk and prevalence of metabolic syndrome) were assessed at the MESA baseline exam (mid- to later life for participants); cardiovascular disease events were ascertained throughout the 20 year follow-up period. Logistic and linear regression models were fit for the relevant outcomes and adjusted for age, sex, nativity, MESA site, parental education, education, income, levels of optimism and pessimism.

Results

These findings suggest some modest associations between reported experiences of ELA related to threat and deprivation and elevated CRP, metabolic dysfunction and increased risk of CVD, however these associations varied by type of ELA and by race/ethnic groups. Unexpectedly, we also found some indirect associations between reported types of ELA and lower risk of those same health outcomes.

Conclusions

The inconsistent trends across race/ethnic groups, ELA dimensions and health outcomes highlight the need for a dimensional approach in classifying experiences of ELA, and suggest potential cultural differences in reporting ELA in adulthood.

在解释早期生活逆境（ELA）暴露与生命后期不良健康结果之间的关系时，涉及了几个生物学过程，但大多数研究都根据童年不良事件（ace）的简单计数将ELA分类。很少有研究也考虑了种族/民族如何改变这些联系。目的：确定ELA的不同维度（威胁和剥夺）在多大程度上影响种族/民族群体的成人心脏代谢和炎症失调。方法：从2000年到2002年招募MESA参与者，年龄45-84岁。有关ELA的信息是在2020年随访电话中收集的。在MESA基线检查中评估炎症（c -反应蛋白，CRP）和心脏代谢功能障碍（代谢综合征风险和患病率指数）的测量（参与者的中老年生活）；在整个20年的随访期间确定心血管疾病事件。Logistic和线性回归模型拟合相关结果，并调整年龄、性别、出生、MESA地点、父母教育程度、教育程度、收入、乐观和悲观水平。结果：这些发现表明，与威胁和剥夺相关的ELA报告经历与CRP升高、代谢功能障碍和CVD风险增加之间存在一定的关联，然而这些关联因ELA类型和种族/民族而异。出乎意料的是，我们还发现报告的ELA类型与相同健康结果的较低风险之间存在一些间接关联。结论：不同种族/民族群体、ELA维度和健康结果的不一致趋势突出了ELA经历分类的维度方法的必要性，并提示在成年期报告ELA时可能存在文化差异。

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引用次数: 0

Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders 展示了非靶向头发蛋白质组学在压力相关疾病中个性化生物标志物的潜力

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-04 DOI: 10.1016/j.psyneuen.2025.107684

Maurizio Sicorello , Jeanne-Carla Sprenger , Lisa M Störkel , Bettina Sarg , Leopold Kremser , Christian Schmahl , Inga Niedtfeld , Alexander Karabatsiakis

Biomarker research in psychopathology increasingly employs high-dimensional Omics approaches. Yet, proteomics based on human hair remain largely unexplored, despite its potential to efficiently capture stable biological signals accumulated over weeks to months. This study leveraged machine learning to investigate the potential of the hair proteome—all detectable peptides and proteins—as a biomarker source for stress-associated psychopathology. We analyzed protein profiles from hair segments of women with non-suicidal self-injury disorder and healthy controls (N = 68). Of 1114 identified proteins, 611 were sufficiently abundant for analyses. Partial Least Squares Discriminant Analysis achieved stable 84.4 % cross-validated accuracy for classification of clinical groups (p < .001), outperforming models based on data-derived clusters (60 %), stress-related proteins (73 %), and simulated hair cortisol from meta-analytic effect sizes (53–59 %). Predicted class probabilities strongly correlated with clinical symptoms and well-being (r > .60). Key predictive proteins were linked to pain perception, oxidative stress, and cholesterol homeostasis. Approximately 15 % of proteins differed significantly between groups, with the strongest candidates related to ribosomal function—an emerging target in depression. These findings establish hair proteomics as a promising, non-invasive biomarker source for psychiatric research with potential clinical applications in risk assessment and personalized interventions.

精神病理学中的生物标志物研究越来越多地采用高维组学方法。然而，基于人类头发的蛋白质组学在很大程度上仍未被探索，尽管它有可能有效地捕获几周到几个月积累的稳定生物信号。这项研究利用机器学习来研究头发蛋白质组的潜力——所有可检测的肽和蛋白质——作为压力相关精神病理学的生物标志物来源。我们分析了非自杀性自残障碍女性和健康对照者头发片段的蛋白质谱（N = 68）。在鉴定的1114个蛋白中，611个蛋白的丰度足以用于分析。偏最小二乘判别分析在临床分组分类中获得了稳定的84.4%交叉验证准确率（p <； ）。001)，优于基于数据衍生聚类（60%）、压力相关蛋白（73%）和模拟毛发皮质醇的meta分析效应大小模型（53 - 59%）。预测分类概率与临床症状和幸福感密切相关（r >； .60）。关键的预测蛋白与疼痛感知、氧化应激和胆固醇稳态有关。大约15%的蛋白质在两组之间存在显著差异，其中最强的候选蛋白与核糖体功能有关——这是抑郁症的一个新兴靶点。这些发现确立了头发蛋白质组学作为一种有前景的、非侵入性的精神病学研究生物标志物来源，在风险评估和个性化干预方面具有潜在的临床应用。

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引用次数: 0

Everyday discrimination frequency, intersectional attributions, and C-reactive Protein for Black midlife women who experience discrimination 黑人中年妇女遭受歧视的日常歧视频率、交叉归因和c反应蛋白

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology

Pub Date : 2025-11-04 DOI: 10.1016/j.psyneuen.2025.107680

Vanessa V. Volpe , Sasha C. Mejía-Bradford , Abbey N. Collins

Discrimination is a chronic psychosocial stressor that elevates the inflammation response. If chronically activated, this elevation may contribute to health risks such as cardiovascular disease and obesity among Black women, who disproportionately experience discrimination at the intersection of racism and sexism. We used cross-sectional data from the Study of Women’s Health Across the Nation to examine how both discrimination frequency and discrimination attributions (single gender, single race, or the intersection of gender and race) relate to levels of the inflammatory biomarker C-reactive protein (CRP) among Black midlife women (n = 209, M_age = 52.67). Midlife represents a critical period for the emergence of cardiometabolic disease, making it an important developmental stage for understanding how discrimination shapes inflammation and health. Participants reported experiencing relatively frequent discrimination during one visit of the study. CRP levels were assayed from blood samples. Using the Detroit Area Study Everyday Discrimination Scale, women reported the frequency with which they experienced discrimination and selected all attributions for that experience from a list of potential social identity statuses. From these responses, we derived single-race, single-gender, and intersectional race-and-gender attribution categories. Linear regression analyses revealed that discrimination frequency was not significantly associated with CRP (p = .424). There was no difference in CRP levels between those who made a single race attribution and those who made an intersectional attribution. Black women who made a single attribution to gender had higher CRP levels compared to those who made an intersectional attribution (β =.14, 95 % CI [.21, 7.01], p = .038). Attributions of discrimination to gender but not, at least in some part, to race may increase health risks for Black midlife women if inflammation is chronically elevated. More research on the content of intersectional attributions of discrimination, above and beyond the frequency of exposure, is needed.

歧视是一种慢性社会心理压力源，可提高炎症反应。如果长期激活，这种升高可能会增加黑人妇女的健康风险，如心血管疾病和肥胖，她们在种族主义和性别歧视的交叉点受到不成比例的歧视。我们使用来自全国妇女健康研究的横断面数据来检查黑人中年妇女中歧视频率和歧视归因（单性别、单种族或性别和种族交叉）与炎症生物标志物c反应蛋白（CRP）水平的关系（n = 209,Mage = 52.67）。中年代表了心脏代谢疾病出现的关键时期，使其成为理解歧视如何影响炎症和健康的重要发展阶段。参与者报告说，在研究的一次访问中，他们经历了相对频繁的歧视。从血液样本中检测CRP水平。使用底特律地区研究日常歧视量表，女性报告了她们遭受歧视的频率，并从潜在的社会身份状态列表中选择了该经历的所有归因。从这些反应中，我们得出了单一种族、单一性别和交叉种族和性别归因类别。线性回归分析显示，辨别率与CRP无显著相关性（p = .424）。在单一种族归因者和交叉种族归因者之间，CRP水平没有差异。单一性别归因的黑人妇女CRP水平高于交叉归因的黑人妇女(β = 0.14, 95 % CI[。[21,7.01], p = .038)。如果炎症长期升高，将歧视归咎于性别，而不是至少在某种程度上归咎于种族，可能会增加黑人中年妇女的健康风险。除了暴露频率之外，还需要对交叉归因歧视的内容进行更多的研究。

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引用次数: 0