Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1603432
M. E. Özen, Mehmet Hamdi Örüm
OBJECTIVE: The available evidence suggests that the main pathological processes underlying Bipolar Disorder and the potential harmful effects of mood episodes are closely related to changes in disorder activity and mood status. Although there are several studies on the existence of a relationship, the results are contradictory. Inflammatory changes occur in various episodes of Bipolar Disorder (BD) Type 1. These changes can be considered as peripheral symptoms of the disorder. In this study, we aimed to compare the inflammatory biomarkers in the BD patients in the manic, depressive and euthymic period with the healthy controls. METHODS: Interleukins (IL) and tumour necrosis factor (TNF) values were measured and compared in 78 healthy controls with 108 patients with BD. RESULTS: There was a statistically significant difference between the patient and control groups in terms of age (p = .040) and educational status (p = .002). There were no statistically significant differences between the BD subgroups with regard to clinical variables such as the age of onset (p = .862), duration of disease (p = .389) and the age of hospitalization (p = .092). In the subgroup of mania, the rate of psychiatric hospitalization was higher than depression or other subgroups (p = .047). When the blood values of peripheral biomarkers (IL-2, IL-4, IL-8, IL-10 and TNFα) were compared, there was no statistically significant difference between the values of the peripheral biomarkers of all BD patients and the control group. The levels of IL10 were higher in the control group than in the BD group, but not statistically significant. CONCLUSIONS: As a result, there was no statistically significant difference between the two groups when comparing serum concentrations of basic IL and TNF in the BD group and control group. There was no difference in the comparison among the patient groups. IL-2 and IL-4 and manic episodes of IL-2 in manic episode were not significant. Therefore, in order to clarify the relationship between inflammatory biomarkers in BD and its possible association with pharmacological treatments, biomarker measurements are required in larger patient samples and ideally at different mood stages and even at different times of the same attack.
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"M. E. Özen, Mehmet Hamdi Örüm","doi":"10.1080/24750573.2019.1603432","DOIUrl":"https://doi.org/10.1080/24750573.2019.1603432","url":null,"abstract":"OBJECTIVE: The available evidence suggests that the main pathological processes underlying Bipolar Disorder and the potential harmful effects of mood episodes are closely related to changes in disorder activity and mood status. Although there are several studies on the existence of a relationship, the results are contradictory. Inflammatory changes occur in various episodes of Bipolar Disorder (BD) Type 1. These changes can be considered as peripheral symptoms of the disorder. In this study, we aimed to compare the inflammatory biomarkers in the BD patients in the manic, depressive and euthymic period with the healthy controls. METHODS: Interleukins (IL) and tumour necrosis factor (TNF) values were measured and compared in 78 healthy controls with 108 patients with BD. RESULTS: There was a statistically significant difference between the patient and control groups in terms of age (p = .040) and educational status (p = .002). There were no statistically significant differences between the BD subgroups with regard to clinical variables such as the age of onset (p = .862), duration of disease (p = .389) and the age of hospitalization (p = .092). In the subgroup of mania, the rate of psychiatric hospitalization was higher than depression or other subgroups (p = .047). When the blood values of peripheral biomarkers (IL-2, IL-4, IL-8, IL-10 and TNFα) were compared, there was no statistically significant difference between the values of the peripheral biomarkers of all BD patients and the control group. The levels of IL10 were higher in the control group than in the BD group, but not statistically significant. CONCLUSIONS: As a result, there was no statistically significant difference between the two groups when comparing serum concentrations of basic IL and TNF in the BD group and control group. There was no difference in the comparison among the patient groups. IL-2 and IL-4 and manic episodes of IL-2 in manic episode were not significant. Therefore, in order to clarify the relationship between inflammatory biomarkers in BD and its possible association with pharmacological treatments, biomarker measurements are required in larger patient samples and ideally at different mood stages and even at different times of the same attack.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"47 1","pages":"113 - 128"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82365095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1608692
B. Karakök, Baki Artık, Yusuf Karaer, V. Y. Kabak, Nilay Şahan, T. Çak, S. Uysal, E. Kültür
Objective: Attention-deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in school-age children. It is accepted that sensory-motor and attention functions are closely associated and up to two thirds of children with ADHD suffer motor skill problems that adversely affect their social adaptation, peer relations, and academic skills. Atomoxetine (ATX) and methylphenidate (MPH) are preferentially used drugs for treatment. MPH is a central nervous system stimulant, whereas ATX is a non-stimulant selective norepinephrine reuptake inhibitor that is used to treat ADHD. The impact of ATX and MPH on attention and ADHD symptoms is well documented. However, the effects of MPH on motor skills are less studied and no data are currently available on the effects of atomoxetine on motor skills. The aim of this study is to investigate the effects of MPH and ATX on gross and fine motor skills in school-aged children with ADHD. Methods: Participants were 36 right-handed boys with ADHD (aged between 6 and 10 years, mean 7.88 years). The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version was used to confirm the diagnosis and rule out other comorbid psychiatric disorders. Gross and fine motor skills were assessed with the Bruininks–Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Twenty-five boys were treated with ATX and 11 with methylphenidate. BOT-2 was applied to both groups before and after 8–12 weeks of treatment. Results: There were no statistically significant differences between the ATX and the MPH groups for all subtests of BOT-2 preand post-medication. When both groups were compared in terms of preand post-treatment gross and fine motor skills, the scores for fine manual control of 12 (48%) children in ATX group increased but did not reach statistical significance. The scores for fine manual control of 5 (45%) children in MPH group increased but did not reach statistical significance. Surprisingly, statistically significant decrease was found in running speed and agility, strength, and body coordination scores in the ATX group, and statistically significant decrease was found in body coordination score in the MPH group. Conclusion: Motor coordination is important in daily life and poor motor skills have a negative impact on a child’s daily living and academic performance. Furthermore, this problem may persist into adulthood with an increase in problems associated with psychosocial adjustment. Our preliminary results revealed that although there was an increase of fine motor control scores after treatment in both groups, statistically significant difference was not found between before and after treatment. Significant decrease in speed and agility and strength scores may be due to reduced impulsivity. While few studies have revealed an improvement on standardized evaluation of attention and motor skills in children taking MPH, more research is needed to gain an understanding of t
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"B. Karakök, Baki Artık, Yusuf Karaer, V. Y. Kabak, Nilay Şahan, T. Çak, S. Uysal, E. Kültür","doi":"10.1080/24750573.2019.1608692","DOIUrl":"https://doi.org/10.1080/24750573.2019.1608692","url":null,"abstract":"Objective: Attention-deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in school-age children. It is accepted that sensory-motor and attention functions are closely associated and up to two thirds of children with ADHD suffer motor skill problems that adversely affect their social adaptation, peer relations, and academic skills. Atomoxetine (ATX) and methylphenidate (MPH) are preferentially used drugs for treatment. MPH is a central nervous system stimulant, whereas ATX is a non-stimulant selective norepinephrine reuptake inhibitor that is used to treat ADHD. The impact of ATX and MPH on attention and ADHD symptoms is well documented. However, the effects of MPH on motor skills are less studied and no data are currently available on the effects of atomoxetine on motor skills. The aim of this study is to investigate the effects of MPH and ATX on gross and fine motor skills in school-aged children with ADHD. Methods: Participants were 36 right-handed boys with ADHD (aged between 6 and 10 years, mean 7.88 years). The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version was used to confirm the diagnosis and rule out other comorbid psychiatric disorders. Gross and fine motor skills were assessed with the Bruininks–Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Twenty-five boys were treated with ATX and 11 with methylphenidate. BOT-2 was applied to both groups before and after 8–12 weeks of treatment. Results: There were no statistically significant differences between the ATX and the MPH groups for all subtests of BOT-2 preand post-medication. When both groups were compared in terms of preand post-treatment gross and fine motor skills, the scores for fine manual control of 12 (48%) children in ATX group increased but did not reach statistical significance. The scores for fine manual control of 5 (45%) children in MPH group increased but did not reach statistical significance. Surprisingly, statistically significant decrease was found in running speed and agility, strength, and body coordination scores in the ATX group, and statistically significant decrease was found in body coordination score in the MPH group. Conclusion: Motor coordination is important in daily life and poor motor skills have a negative impact on a child’s daily living and academic performance. Furthermore, this problem may persist into adulthood with an increase in problems associated with psychosocial adjustment. Our preliminary results revealed that although there was an increase of fine motor control scores after treatment in both groups, statistically significant difference was not found between before and after treatment. Significant decrease in speed and agility and strength scores may be due to reduced impulsivity. While few studies have revealed an improvement on standardized evaluation of attention and motor skills in children taking MPH, more research is needed to gain an understanding of t","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"60 1","pages":"264 - 310"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84885978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1648733
Ado-Baba Ahmed, A. A. Zubairu, A. Ahmed, Fatima Lamido, Mayowa Niyi
s 1 Optical coherence tomography findings in autism spectrum disorder and healthy controls Mahmut Zabit Kara and Mehmet Hamdi Örüm 1 Blood levels of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha and cognitive functions in patients with obsessive compulsive disorder Evrim Özkorumak Karagüzel, Filiz Civil Arslan, Demet Sağlam Aykut, Emel Uysal, Selim Demir, Mustafa Tat and Süleyman Caner Karahan 3 Relationship of self-mutilative behaviour with internet gaming disorder symptoms and emotion dysregulation among young adults Bilge Evren 5 Comparative evaluation of somatization and abnormal illness behaviors in fibromyalgia patients with diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) and diagnostic criteria for psychosomatic research (DCPR) Gizem Kara, Filiz Civil Arslan, Evrim Özkorumak Karagüzel and Demet Sağlam Aykut 5 Obsessive-compulsive disorder, genetic issues and internal health issues Şaban Karayağız 6 Platelet count and platelet lymphocyte ratio in patients with psychosis Hasan Korkmaz, Sevda Korkmaz, Sema Baykara, Dilek Ulukan, Ayşe Merve Denk and Sevler Yıldız 7 Evaluation of the correlation between smoking and sex life in a non-clinical sample Sevda Korkmaz, Sema Baykara and Hasan Korkmaz 7 Comparison of patients with mild and severe fibromyalgia syndrome in terms of coping ways Sema Baykara 8 Neuropsychiatric and sociodemographic features of centenarian people who live in rize Tuğba Uyar and Neslihan Deniz 9 Evaluation of impulsivity and the relationship between affective symptoms and impulsivity in patients with epilepsy Selen Işık Ulusoy and Bahriye Horasanlı 9 The determination of vitamin D, vitamin B12 and folic acid levels of patient in pychiatry clinic Faruk Kiliç, Cemile Aksoy, Arif Demirdaş and Ümit Işik 10 Investıgatıon of psychopathology and related varıables In adolescents wıth conversıon dısorders Serhat Kala, Ender Atabay, Dilşad Foto Özdemir and Ferhunde Öktem 11 Optimization of therapeutic tactics in patients with opioid addiction Vasila Abdullaeva 11 Cultural dependence of attitude towards psychotherapeutic treatment german compared to Turkish people in first and second generation Dilek Sahin 12 Evaluation of the clinical features of schizophrenia patients following psychosocial skills training in a community mental health center of a training and research hospital Esin Erdoğan and Dursun Hakan Delibaş 13 Sociodemographic and clinical characteristics of voluntary and involuntary psychiatric admissions in a foundation university hospital Buğra Çetin 13 The relationship between leptin receptor polymorphism and suicide in depressed adolescents Sadettin Burak Açıkel, Canan Eroğlu, Asiye Uğraş Dikmen and Ercan Kurar 14 The relationship between expressed emotion and treatment resistance in patients with major depression Fatih Baz, Erdoğdu Akça and Mesut Yıldız 15 Comparison of fetal and maternal attachment between peripartum anxiety disorder diagnosed and healthy women Buket Güngö
{"title":"Online Table of Contents","authors":"Ado-Baba Ahmed, A. A. Zubairu, A. Ahmed, Fatima Lamido, Mayowa Niyi","doi":"10.1080/24750573.2019.1648733","DOIUrl":"https://doi.org/10.1080/24750573.2019.1648733","url":null,"abstract":"s 1 Optical coherence tomography findings in autism spectrum disorder and healthy controls Mahmut Zabit Kara and Mehmet Hamdi Örüm 1 Blood levels of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha and cognitive functions in patients with obsessive compulsive disorder Evrim Özkorumak Karagüzel, Filiz Civil Arslan, Demet Sağlam Aykut, Emel Uysal, Selim Demir, Mustafa Tat and Süleyman Caner Karahan 3 Relationship of self-mutilative behaviour with internet gaming disorder symptoms and emotion dysregulation among young adults Bilge Evren 5 Comparative evaluation of somatization and abnormal illness behaviors in fibromyalgia patients with diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) and diagnostic criteria for psychosomatic research (DCPR) Gizem Kara, Filiz Civil Arslan, Evrim Özkorumak Karagüzel and Demet Sağlam Aykut 5 Obsessive-compulsive disorder, genetic issues and internal health issues Şaban Karayağız 6 Platelet count and platelet lymphocyte ratio in patients with psychosis Hasan Korkmaz, Sevda Korkmaz, Sema Baykara, Dilek Ulukan, Ayşe Merve Denk and Sevler Yıldız 7 Evaluation of the correlation between smoking and sex life in a non-clinical sample Sevda Korkmaz, Sema Baykara and Hasan Korkmaz 7 Comparison of patients with mild and severe fibromyalgia syndrome in terms of coping ways Sema Baykara 8 Neuropsychiatric and sociodemographic features of centenarian people who live in rize Tuğba Uyar and Neslihan Deniz 9 Evaluation of impulsivity and the relationship between affective symptoms and impulsivity in patients with epilepsy Selen Işık Ulusoy and Bahriye Horasanlı 9 The determination of vitamin D, vitamin B12 and folic acid levels of patient in pychiatry clinic Faruk Kiliç, Cemile Aksoy, Arif Demirdaş and Ümit Işik 10 Investıgatıon of psychopathology and related varıables In adolescents wıth conversıon dısorders Serhat Kala, Ender Atabay, Dilşad Foto Özdemir and Ferhunde Öktem 11 Optimization of therapeutic tactics in patients with opioid addiction Vasila Abdullaeva 11 Cultural dependence of attitude towards psychotherapeutic treatment german compared to Turkish people in first and second generation Dilek Sahin 12 Evaluation of the clinical features of schizophrenia patients following psychosocial skills training in a community mental health center of a training and research hospital Esin Erdoğan and Dursun Hakan Delibaş 13 Sociodemographic and clinical characteristics of voluntary and involuntary psychiatric admissions in a foundation university hospital Buğra Çetin 13 The relationship between leptin receptor polymorphism and suicide in depressed adolescents Sadettin Burak Açıkel, Canan Eroğlu, Asiye Uğraş Dikmen and Ercan Kurar 14 The relationship between expressed emotion and treatment resistance in patients with major depression Fatih Baz, Erdoğdu Akça and Mesut Yıldız 15 Comparison of fetal and maternal attachment between peripartum anxiety disorder diagnosed and healthy women Buket Güngö","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"26 1","pages":"i - xxvi"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78991243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1608065
E. Atabay, A. Arman
Atypical antipsychotics (SGA) are used as first choice but this group of drugs may cause relatively more metabolic problems. Diabetic ketoacidosis (DCA) known as an acute, life-threatening complication of diabetes, can be triggered by use of SGA. In this presentation, we present a 17year-old male patient who had DCA that thought to be triggered by olanzapine treatment. Case presentation: E. has been followed up and treated for about 6 years in child and adolescent psychiatry outpatient clinic. He had no history of smoking, alcohol or substance abuse in any period of his life. There was no history of psychiatric disease in the family. His aunt has a history of type 2 diabetes. The first time he consulted us was about 2 years agowith the complaint of irritability, harm to his family and sleep problems. In this interview, we learned that she had been treated with risperidone 2 mg/day but had no benefit. Mental status examination revealed any hypomanic, manic, psychotic symptoms and signs. Aripiprazole 5 mg/day treatment was arranged and he benefited from drug. Patient was admitted again after 2.5 months and family had complaints of “inability to sleep, fears, biting himself, talking to himself”. Avolition, dirtiness obsessions and cleaning compulsions, visual, auditory and auditory hallucinations were determined in the examination. Patient was referred to child neurology and psychiatric hospitalization was recommended. However family did not want hospitalization and no pathology was found in her neurological examination. Patient was planned to have olanzapine 5 mg, 2 times a day. Approximately 1.5 months later, the patient re-admitted to us, he was so irritable, anxious, unsleeping and suggested to continuation of olanzapine in morning 5 mg and evening 10 mg. In third week of treatment, patient was admitted to the emergency room with nausea, vomiting, abdominal pain and blurred consciousness. In the evaluation; blood glucose 434 mg/dl, urine glucose 3+, protein 2+, ketone 3+, pH 6.0; The blood gas pH was found to be 7.146 and it was accepted to the pediatric intensive care unit with diagnosis of diabetic ketoacidosis. Olanzapine treatment was discontinued and he was discharged with insulin therapy. The patient is still followed up with aripiprazole 15 mg/day treatment. How SGA lead to hyperglycemia remains unclear. Due to the weight gain effects of olanzapine, increasing peripheral and hepatic insulin resistance and stimulating X receptor are most known factors contributing to this effect. This mechanism does not seem possible to explain the rapid onset of diabetes. Some clinical trials with olanzapine have shown biphasic changes in insulin secretion in patients. Olanzapine acts on direct beta cells in the early period of treatment and that insulin secretion decreases significantly may accompany this metabolic condition. As in our patient, it is stated that this possibility increases in case of genetic predisposition. Particular attention should be
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"E. Atabay, A. Arman","doi":"10.1080/24750573.2019.1608065","DOIUrl":"https://doi.org/10.1080/24750573.2019.1608065","url":null,"abstract":"Atypical antipsychotics (SGA) are used as first choice but this group of drugs may cause relatively more metabolic problems. Diabetic ketoacidosis (DCA) known as an acute, life-threatening complication of diabetes, can be triggered by use of SGA. In this presentation, we present a 17year-old male patient who had DCA that thought to be triggered by olanzapine treatment. Case presentation: E. has been followed up and treated for about 6 years in child and adolescent psychiatry outpatient clinic. He had no history of smoking, alcohol or substance abuse in any period of his life. There was no history of psychiatric disease in the family. His aunt has a history of type 2 diabetes. The first time he consulted us was about 2 years agowith the complaint of irritability, harm to his family and sleep problems. In this interview, we learned that she had been treated with risperidone 2 mg/day but had no benefit. Mental status examination revealed any hypomanic, manic, psychotic symptoms and signs. Aripiprazole 5 mg/day treatment was arranged and he benefited from drug. Patient was admitted again after 2.5 months and family had complaints of “inability to sleep, fears, biting himself, talking to himself”. Avolition, dirtiness obsessions and cleaning compulsions, visual, auditory and auditory hallucinations were determined in the examination. Patient was referred to child neurology and psychiatric hospitalization was recommended. However family did not want hospitalization and no pathology was found in her neurological examination. Patient was planned to have olanzapine 5 mg, 2 times a day. Approximately 1.5 months later, the patient re-admitted to us, he was so irritable, anxious, unsleeping and suggested to continuation of olanzapine in morning 5 mg and evening 10 mg. In third week of treatment, patient was admitted to the emergency room with nausea, vomiting, abdominal pain and blurred consciousness. In the evaluation; blood glucose 434 mg/dl, urine glucose 3+, protein 2+, ketone 3+, pH 6.0; The blood gas pH was found to be 7.146 and it was accepted to the pediatric intensive care unit with diagnosis of diabetic ketoacidosis. Olanzapine treatment was discontinued and he was discharged with insulin therapy. The patient is still followed up with aripiprazole 15 mg/day treatment. How SGA lead to hyperglycemia remains unclear. Due to the weight gain effects of olanzapine, increasing peripheral and hepatic insulin resistance and stimulating X receptor are most known factors contributing to this effect. This mechanism does not seem possible to explain the rapid onset of diabetes. Some clinical trials with olanzapine have shown biphasic changes in insulin secretion in patients. Olanzapine acts on direct beta cells in the early period of treatment and that insulin secretion decreases significantly may accompany this metabolic condition. As in our patient, it is stated that this possibility increases in case of genetic predisposition. Particular attention should be ","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"19 1","pages":"129 - 263"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89460023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1603000
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"","doi":"10.1080/24750573.2019.1603000","DOIUrl":"https://doi.org/10.1080/24750573.2019.1603000","url":null,"abstract":"","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"22 1","pages":"1 - 112"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85055633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-22DOI: 10.1080/24750573.2019.1636483
Ayşegül Kart, H. Türkçapar
ABSTRACT OBJECTIVE: The purpose of this study was to evaluate the relationship between childhood traumas (CTs) and severity and symptom dimensions of Obsessive Compulsive Disorder (OCD). METHOD: One hundred and sixty (160) patients diagnosed with OCD were included. The Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Childhood Trauma Questionnaire (CTQ), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI) were applied to the participants. RESULTS: According to a cut-off score of > 35 for CTQ total score, 71 (44.4%) OCD patients had no CT history and 89 (55.6%) OCD patients had CTs history. There were no significant difference between the two groups with regard to YBOCS total score or to obsessions and compulsions except aggressive obsessions. The associations between aggressive obsessions, BDI total score, BAI total score and emotional abuse were statistically significant, but the correlation between aggressive obsessions and emotional abuse was no longer significant after controlling for BDI and BAI total scores. In the parallel multiple mediator model analysis, there were not statistically significant mediator effects of depression and anxiety variables in the relationship between emotional abuse and aggressive obsessions. Mobility in childhood was significantly correlated with physical abuse, and this correlation was still significant after controlling for BDI and BAI total scores. BDI total score was significantly associated with sexual abuse. CONCLUSION: The relationship between CTs and OCD should be reconsidered in light of other contributing factors such as comorbidity.
{"title":"The effects of childhood emotional abuse on aggressive obsessions among patients with obsessive compulsive disorder may be mediated by symptoms of depression and anxiety","authors":"Ayşegül Kart, H. Türkçapar","doi":"10.1080/24750573.2019.1636483","DOIUrl":"https://doi.org/10.1080/24750573.2019.1636483","url":null,"abstract":"ABSTRACT OBJECTIVE: The purpose of this study was to evaluate the relationship between childhood traumas (CTs) and severity and symptom dimensions of Obsessive Compulsive Disorder (OCD). METHOD: One hundred and sixty (160) patients diagnosed with OCD were included. The Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Childhood Trauma Questionnaire (CTQ), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI) were applied to the participants. RESULTS: According to a cut-off score of > 35 for CTQ total score, 71 (44.4%) OCD patients had no CT history and 89 (55.6%) OCD patients had CTs history. There were no significant difference between the two groups with regard to YBOCS total score or to obsessions and compulsions except aggressive obsessions. The associations between aggressive obsessions, BDI total score, BAI total score and emotional abuse were statistically significant, but the correlation between aggressive obsessions and emotional abuse was no longer significant after controlling for BDI and BAI total scores. In the parallel multiple mediator model analysis, there were not statistically significant mediator effects of depression and anxiety variables in the relationship between emotional abuse and aggressive obsessions. Mobility in childhood was significantly correlated with physical abuse, and this correlation was still significant after controlling for BDI and BAI total scores. BDI total score was significantly associated with sexual abuse. CONCLUSION: The relationship between CTs and OCD should be reconsidered in light of other contributing factors such as comorbidity.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"17 1","pages":"411 - 417"},"PeriodicalIF":0.7,"publicationDate":"2019-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83219755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-11DOI: 10.1080/24750573.2019.1637326
Börte Gürbüz Özgür, H. Aksu, E. Eser
ABSTRACT Objective: The aim of this study is to present the psychometric properties of the Turkish version of the knowledge about childhood autism among health workers (KCAHW) questionnaire. Methods: Three hundred fifteen primary health care facility workers and 28 child and adolescent mental health professionals were enrolled in this study. Participants filled out socio-demographic data forms and the KCAHW. Reliability analyses consisted of internal consistency and test–retest reliability. For validity analysis, construct validity (confirmatory factor analysis -CFA) and criterion validity were used. Results: The mean KCAHW questionnaire score was 13.83 ± 2.55. The floor effects in all domains were below 15%, the ceiling effects were over 15% in overall score and in Domain 4. Intraclass correlation coefficient and the Kuder Richardson 21 values were 0.83 and 0.683, respectively; All goodness of fit indices generated by CFA were found satisfactory (Comparative fit index = 0.79; Root mean square error of approximation = 0.056, and chi-square/degree of freedom = 1.91). Being a physician, being a CAMH specialist, having mental health clinic experience, having done a child psychiatry internship, knowing someone diagnosed with autism, follow-up experience of a patient with autism, having previous autism training, and the perception of adequate knowledge about autism, significantly increased the KCAHW scores (p < 0.001). Conclusion: The Turkish version of the KCAHW questionnaire is reliable (in terms of test-retest and internal consistency) and valid (sensitive some known/expected external criteria). Due to the insufficient internal consistency in Domain 4, the scores received from Domain 4 should be evaluated with caution.
{"title":"Validity and reliability of the Turkish version of the knowledge about childhood autism among health workers questionnaire","authors":"Börte Gürbüz Özgür, H. Aksu, E. Eser","doi":"10.1080/24750573.2019.1637326","DOIUrl":"https://doi.org/10.1080/24750573.2019.1637326","url":null,"abstract":"ABSTRACT Objective: The aim of this study is to present the psychometric properties of the Turkish version of the knowledge about childhood autism among health workers (KCAHW) questionnaire. Methods: Three hundred fifteen primary health care facility workers and 28 child and adolescent mental health professionals were enrolled in this study. Participants filled out socio-demographic data forms and the KCAHW. Reliability analyses consisted of internal consistency and test–retest reliability. For validity analysis, construct validity (confirmatory factor analysis -CFA) and criterion validity were used. Results: The mean KCAHW questionnaire score was 13.83 ± 2.55. The floor effects in all domains were below 15%, the ceiling effects were over 15% in overall score and in Domain 4. Intraclass correlation coefficient and the Kuder Richardson 21 values were 0.83 and 0.683, respectively; All goodness of fit indices generated by CFA were found satisfactory (Comparative fit index = 0.79; Root mean square error of approximation = 0.056, and chi-square/degree of freedom = 1.91). Being a physician, being a CAMH specialist, having mental health clinic experience, having done a child psychiatry internship, knowing someone diagnosed with autism, follow-up experience of a patient with autism, having previous autism training, and the perception of adequate knowledge about autism, significantly increased the KCAHW scores (p < 0.001). Conclusion: The Turkish version of the KCAHW questionnaire is reliable (in terms of test-retest and internal consistency) and valid (sensitive some known/expected external criteria). Due to the insufficient internal consistency in Domain 4, the scores received from Domain 4 should be evaluated with caution.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"28 1","pages":"765 - 773"},"PeriodicalIF":0.7,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82978110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objective: The objective in this study was to analyse the effects of the perceived social support from the family, friends and other important people in the lives of patients with bipolar disorder(BD) in remission on clinical course and suicidal behaviour in a multidimensional model. Method: The study conducted 100 patients diagnosed with BD-1(remission) according to DSM-5. All participants were administered Multidimensional Scale of Perceived Social Support(MSPSS), Young Mani Rating Scale(YMRS), Patient Health Questionnaire(PHQ-SADS,) Mood Disorder Diagnosis and Monitoring Form(SKIP-TURK), and Global Assessment of Functioning(GAF). Results: There was a significant negative correlation between the duration of untreated period(DUP), episodes length, illness duration, subthreshold depressive symptoms and their MSPSS scores (p < .05). There was a significant difference in the MSPSS total scores (not subscales) between the two groups divided according to suicidal behaviour (p = .03). There was a significant positive correlation between the GAF scores and the all MSPSS subscales scores. GAF and MSPSS friends_subscale scores were found to be predictors for suicide behaviour (respectively;Wald = 4.81, p = .028, OR = .93, %95 CI = 0.88-0.99;Wald = 4.71, p = .03, OR = 1.08, %95 CI = 1,01–1,16). Conclusion: This study indicates that there are significant relationships between suicide attempts, DUP, episode length, subthreshold depressive symptoms, functioning and multidimensionally perceived social support. The fact that suicide attempt is related to total score and not to subscale scores of perceived social support shows the importance of the coexistence of all dimensions in the perceived social support area and emphasizes the necessity of examining these dimensions as a whole. Meanwhile, it is observed that the perceived friend_support along with functioning is associated with suicidal behaviour in BD.
摘要目的:本研究旨在通过多维模型分析双相情感障碍(BD)缓解期患者感知到的来自家庭、朋友和其他生活中重要人物的社会支持对其临床病程和自杀行为的影响。方法:根据DSM-5对100例诊断为BD-1(缓解)的患者进行研究。所有参与者均接受多维感知社会支持量表(MSPSS)、Young Mani评定量表(YMRS)、患者健康问卷(PHQ-SADS)、情绪障碍诊断和监测表(skp - turk)和整体功能评估(GAF)。结果:未治疗期(DUP)、发作时间、病程、阈下抑郁症状与MSPSS评分呈显著负相关(p < 0.05)。两组按自杀行为划分的MSPSS总分(非亚量表)差异有统计学意义(p = .03)。GAF得分与所有MSPSS分量表得分之间存在显著的正相关。GAF和MSPSS friends_subscale得分分别被发现是自杀行为的预测因子(Wald = 4.81, p =。028 = iseq指数,% 95 CI = 0.88 - -0.99;瓦尔德= 4.71,p =。03, or = 1.08， %95 ci = 1,01 - 1,16)。结论:自杀企图、DUP、发作时长、阈下抑郁症状、功能与多维感知社会支持之间存在显著相关。自杀企图与感知社会支持的总分有关，而与感知社会支持的子量表得分无关，这一事实显示了感知社会支持领域中所有维度共存的重要性，并强调了将这些维度作为一个整体进行研究的必要性。同时，观察到朋友支持的感知与功能与双相障碍患者的自杀行为有关。
{"title":"Bipolar disorder and perceived social support: relation with clinical course, and the role of suicidal behaviour","authors":"Ozlem Kazan Kizilkurt, Ferzan Ergun Giynas, Medine Yazici Gulec, H. Gulec","doi":"10.1080/24750573.2019.1639410","DOIUrl":"https://doi.org/10.1080/24750573.2019.1639410","url":null,"abstract":"ABSTRACT Objective: The objective in this study was to analyse the effects of the perceived social support from the family, friends and other important people in the lives of patients with bipolar disorder(BD) in remission on clinical course and suicidal behaviour in a multidimensional model. Method: The study conducted 100 patients diagnosed with BD-1(remission) according to DSM-5. All participants were administered Multidimensional Scale of Perceived Social Support(MSPSS), Young Mani Rating Scale(YMRS), Patient Health Questionnaire(PHQ-SADS,) Mood Disorder Diagnosis and Monitoring Form(SKIP-TURK), and Global Assessment of Functioning(GAF). Results: There was a significant negative correlation between the duration of untreated period(DUP), episodes length, illness duration, subthreshold depressive symptoms and their MSPSS scores (p < .05). There was a significant difference in the MSPSS total scores (not subscales) between the two groups divided according to suicidal behaviour (p = .03). There was a significant positive correlation between the GAF scores and the all MSPSS subscales scores. GAF and MSPSS friends_subscale scores were found to be predictors for suicide behaviour (respectively;Wald = 4.81, p = .028, OR = .93, %95 CI = 0.88-0.99;Wald = 4.71, p = .03, OR = 1.08, %95 CI = 1,01–1,16). Conclusion: This study indicates that there are significant relationships between suicide attempts, DUP, episode length, subthreshold depressive symptoms, functioning and multidimensionally perceived social support. The fact that suicide attempt is related to total score and not to subscale scores of perceived social support shows the importance of the coexistence of all dimensions in the perceived social support area and emphasizes the necessity of examining these dimensions as a whole. Meanwhile, it is observed that the perceived friend_support along with functioning is associated with suicidal behaviour in BD.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"203 1","pages":"787 - 793"},"PeriodicalIF":0.7,"publicationDate":"2019-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73112891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-09DOI: 10.1080/24750573.2019.1631942
E. Deveci, Alperen Kılıç, O. Yılmaz, Aynur Nabi, A. S. Ergün, A. Bozkurt, A. Kurtulmuş, A. Öztürk, M. Eşrefoğlu, M. Aydın, Ebru Şahan, I. Kırpınar
ABSTRACT Background: Deep Brain Stimulation (DBS) is the only modality proven to be effective on selective stimulation of the deep brain structures. It was previously reported that, by using DBS, stimulation of nucleus accumbens (NA), a region that plays a pivotal role in the pathogenesis of substance addiction, is effective for the treatment of substance addiction. Objective: The purpose of the current study was to observe how the morphine-conditioned place preference changed in rats by stimulating NA with a non-invasive method, focused ultrasound (US) and to detect whether there would be any tissue damage caused by US waves. Methods: We used low-intensity focused ultrasound (LIFU), a noninvasive modality, in a place conditioning model to stimulate NA in rats. Results: At the initial stage of our study, we used morphine to induce place preference. As expected, morphine administration caused significant place preference. After the place preference was obtained by morphine, we divided the rats into two groups. One group received LIFU waves to NA and the other group received only sham, that is, no stimulation with US waves. Rats in both groups were continued to receive morphine. Then, we investigated whether LIFU and sham will reduce morphine-induced place preference or not. We observed that morphine-induced place preference had an ongoing raise in the sham group while no raise was detected in the ultrasound group. Although LIFU prevented the rats from the raise, it did not cause a significant reduction of morphine preference. Conclusion: We state that there is a need for future studies to investigate the effects of low-intensity focused ultrasound as an alternative treatment modality in addiction.
{"title":"The effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats","authors":"E. Deveci, Alperen Kılıç, O. Yılmaz, Aynur Nabi, A. S. Ergün, A. Bozkurt, A. Kurtulmuş, A. Öztürk, M. Eşrefoğlu, M. Aydın, Ebru Şahan, I. Kırpınar","doi":"10.1080/24750573.2019.1631942","DOIUrl":"https://doi.org/10.1080/24750573.2019.1631942","url":null,"abstract":"ABSTRACT Background: Deep Brain Stimulation (DBS) is the only modality proven to be effective on selective stimulation of the deep brain structures. It was previously reported that, by using DBS, stimulation of nucleus accumbens (NA), a region that plays a pivotal role in the pathogenesis of substance addiction, is effective for the treatment of substance addiction. Objective: The purpose of the current study was to observe how the morphine-conditioned place preference changed in rats by stimulating NA with a non-invasive method, focused ultrasound (US) and to detect whether there would be any tissue damage caused by US waves. Methods: We used low-intensity focused ultrasound (LIFU), a noninvasive modality, in a place conditioning model to stimulate NA in rats. Results: At the initial stage of our study, we used morphine to induce place preference. As expected, morphine administration caused significant place preference. After the place preference was obtained by morphine, we divided the rats into two groups. One group received LIFU waves to NA and the other group received only sham, that is, no stimulation with US waves. Rats in both groups were continued to receive morphine. Then, we investigated whether LIFU and sham will reduce morphine-induced place preference or not. We observed that morphine-induced place preference had an ongoing raise in the sham group while no raise was detected in the ultrasound group. Although LIFU prevented the rats from the raise, it did not cause a significant reduction of morphine preference. Conclusion: We state that there is a need for future studies to investigate the effects of low-intensity focused ultrasound as an alternative treatment modality in addiction.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"122 1","pages":"748 - 759"},"PeriodicalIF":0.7,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87421386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-09DOI: 10.1080/24750573.2019.1637393
Serkan Turan, A. Akay
ABSTRACT Background: We aimed to examine the long-term effects of atomoxetine on height, weight, and body mass index in Turkish children and adolescents with attention deficit hyperactivity disorder (ADHD). Methods: Participants (6–18 years, 146 boys, 52 girls) with ADHD who used atomoxetine for at least 1 year were included in a retrospective study. Weight, height, and BMI z scores were converted to age- and gender- corrected z scores at baseline and last follow-up. Results: Atomoxetine treatment was associated with a notional reduction in height and weight standard deviation scores (SDS). There were no differences in BMI-SDS before and after atomoxetine treatment. Results of multiple linear regression analysis assess the possible contribution of the different treatment-related factors, age starting treatment, and duration of treatment predicted final height. And also, only the duration of treatment predicted final weight, not final height and BMI. Conclusions: We conclude that atomoxetine shows a negative effect on height and weight in children. This study demonstrated that these findings obtained at the end of the study might be helpful in assessing the growth parameters that may facilitate the course of the ADHD.
{"title":"The effects of atomoxetine on weight, height, and body mass index in Turkish children and adolescents with attention deficit hyperactivity disorder","authors":"Serkan Turan, A. Akay","doi":"10.1080/24750573.2019.1637393","DOIUrl":"https://doi.org/10.1080/24750573.2019.1637393","url":null,"abstract":"ABSTRACT Background: We aimed to examine the long-term effects of atomoxetine on height, weight, and body mass index in Turkish children and adolescents with attention deficit hyperactivity disorder (ADHD). Methods: Participants (6–18 years, 146 boys, 52 girls) with ADHD who used atomoxetine for at least 1 year were included in a retrospective study. Weight, height, and BMI z scores were converted to age- and gender- corrected z scores at baseline and last follow-up. Results: Atomoxetine treatment was associated with a notional reduction in height and weight standard deviation scores (SDS). There were no differences in BMI-SDS before and after atomoxetine treatment. Results of multiple linear regression analysis assess the possible contribution of the different treatment-related factors, age starting treatment, and duration of treatment predicted final height. And also, only the duration of treatment predicted final weight, not final height and BMI. Conclusions: We conclude that atomoxetine shows a negative effect on height and weight in children. This study demonstrated that these findings obtained at the end of the study might be helpful in assessing the growth parameters that may facilitate the course of the ADHD.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"144 1","pages":"781 - 786"},"PeriodicalIF":0.7,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80349127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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